MCID: BRD004
MIFTS: 53

Borderline Personality Disorder malady

Summaries for Borderline Personality Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods.

MalaCards: Borderline Personality Disorder is related to personality disorder and bipolar disorder. An important gene associated with Borderline Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Monoamine GPCRs and Tryptophan metabolism. The compounds m-chlorophenylpiperazine and naratriptan have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and amygdala, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Wikipedia:63 Borderline personality disorder (BPD) (called emotionally unstable personality disorder, emotional... more...

Aliases & Classifications for Borderline Personality Disorder

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

borderline personality disorder 8 10 44 60


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Disease Ontology8 DOID:10930
MeSH34 D001883
SNOMED-CT56 192488005, 20010003
ICD9CM27 301.83

Related Diseases for Borderline Personality Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Borderline Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder32.2HTR1B, MAOA, TTF2, SLC6A4, TPH1, TPH2
2bipolar disorder31.1SLC6A4, HTR2A, HTR3A
3bulimia nervosa30.8COMT, BDNF, HTR1B, HTR3A, HTR2A, MAOA
4substance dependence30.7TPH1, SLC6A4, COMT
5antisocial personality disorder30.6HTR1B, HTR2A, MAOA, TTF2, SLC6A4
6attention deficit hyperactivity disorder30.6COMT, BDNF, HTR1B, HTR2A, MAOA, SLC6A4
7mood disorder30.6HTR2A, CRH, MAOA, SLC6A4, TPH1, TPH2
8eating disorder30.6SLC6A4
9anorexia nervosa30.5BDNF, HTR2A
10conduct disorder30.5COMT, MAOA, TTF2, SLC6A4
11anxiety disorder30.5BDNF, HTR3A, CRH, MAOA, SLC6A4, TPH1
12drug dependence30.3SLC6A4, MAOA
13substance abuse30.3SLC6A4, CRH
14obsessive-compulsive personality disorder30.3CLPS, SLC6A4
15schizotypal personality disorder30.3COMT, FLNA
16schizophrenia30.3COMT, HTR2A
17obsessive-compulsive disorder30.3TPH2, TPH1, SLC6A4, COMT, BDNF, HTR1B
18nicotine dependence30.1SLC6A4
19cocaine dependence30.1SLC6A4
20melancholia30.1CRH, MAOA
21dysthymic disorder30.1HTR2A, MAOA
22panic disorder30.1HTR1A, HTR3A, CRH, SLC6A4
23social phobia30.1COMT, HTR1A, HTR3A, MAOA, SLC6A4
24alcohol dependence30.1MAOA, SLC6A4, CRH, HTR2A, HTR1B
25polycystic ovary syndrome30.1PRL, CRH
26obesity30.1COMT, HTR1A, HTR2A, CRH, MAOA, CLPS
27psychotic disorder30.1COMT, BDNF, HTR1A, HTR3A, HTR2A, PRL
28major depressive disorder10.7
29dependent personality disorder10.7
30sexual disorder10.6
31dissociative disorder10.5
32sleep disorder10.5
33pain disorder10.5
34avoidant personality disorder10.4
35somatoform disorder10.4
36multiple personality disorder10.4
37heroin dependence10.4
38post-traumatic stress disorder10.4
39alexithymia10.3
40narcissistic personality disorder10.2
41cerebritis10.2
42somatization disorder10.2
43rumination disorder10.2
44impulse control disorder10.2
45prolactinoma10.1
46cannabis dependence10.1
47expressive language disorder10.1
48schizophreniform disorder10.1
49hypochondriasis10.1
50asperger syndrome10.1

Graphical network of the top 20 diseases related to Borderline Personality Disorder:



Diseases related to borderline personality disorder

Clinical Features for Borderline Personality Disorder

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Drugs & Therapeutics for Borderline Personality Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Borderline Personality Disorder

Drug clinical trials:

Search ClinicalTrials for Borderline Personality Disorder

Search NIH Clinical Center for Borderline Personality Disorder

Search CenterWatch for Borderline Personality Disorder

Genetic Tests for Borderline Personality Disorder

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Anatomical Context for Borderline Personality Disorder

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32MalaCards
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MalaCards organs/tissues related to Borderline Personality Disorder:

32
Bone, Brain, Amygdala, Testes, Pituitary, Cortex, Ovary, Prefrontal cortex

Animal Models for Borderline Personality Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Borderline Personality Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.3HTR3A, HTR2A, CRH, PRL, AVPR1A, SLC6A4
2MP:00053859.0COMT, HTR1B, HTR1A, FLNA, MAOA, AVPR1A
3MP:00107718.8BDNF, HTR3A, CRH, PRL, CLPS, SLC6A4
4MP:00036318.6COMT, BDNF, HTR1A, HTR3A, CRH, FLNA
5MP:00053768.4COMT, BDNF, HTR1A, HTR3A, CRH, FLNA
6MP:00053868.1TPH2, COMT, BDNF, HTR1B, HTR1A, HTR3A

Publications for Borderline Personality Disorder

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50PubMed
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Articles related to Borderline Personality Disorder:

(show top 50)    (show all 585)
idTitleAuthorsYear
1
Co-occurrence of dissociative identity disorder and borderline personality disorder. (24377974)
2014
2
Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder. (22404662)
2013
3
Symptoms of borderline personality disorder predict interpersonal (but not independent) stressful life events in a community sample of older adults. (23713502)
2013
4
Borderline personality disorder and emotional intelligence. (23364117)
2013
5
Treatment of borderline personality disorder in youth. (23970912)
2013
6
Longitudinal twin study of borderline personality disorder traits and substance use in adolescence: developmental change, reciprocal effects, and genetic and environmental influences. (22642461)
2013
7
Morphometric differences in central stress-regulating structures between women with and without borderline personality disorder. (22909445)
2013
8
Borderline personality disorder and chronic pain: a practical approach to evaluation and treatment. (23801003)
2013
9
Structure of genetic and environmental risk factors for symptoms of DSM-IV borderline personality disorder. (24048243)
2013
10
Evaluation of psychotherapeutic effects on borderline personality disorder: a case report. (23793284)
2013
11
Combined group and individual schema therapy for borderline personality disorder: A pilot study. (24342235)
2013
12
Maternal transmission of borderline personality disorder symptoms in the community-based Greifswald Family Study. (22928848)
2013
13
Social Perception in Borderline Personality Disorder: The Role of Context. (23445472)
2013
14
Gestalt psychotherapy in the outpatient treatment of borderline personality disorder: a case report. (23417637)
2013
15
Magnetic resonance imaging in patients with borderline personality disorder: a study of volumetric abnormalities. (23684978)
2013
16
Management of borderline personality disorder. (23027916)
2012
17
An Empirical Examination of Gunderson's Proposed Revision of the Diagnostic Algorithm for Borderline Personality Disorder. (22984857)
2012
18
Exploring the interface of neurobehaviorally linked personality dimensions and personality organization in borderline personality disorder: the Multidimensional Personality Questionnaire and Inventory of Personality Organization. (23281675)
2012
19
Suicidal risk and management in borderline personality disorder. (22113831)
2012
20
Depression and borderline personality disorder. (23230925)
2012
21
Frequency of Borderline Personality Disorder Among Psychiatric Outpatients in Shanghai. (22494175)
2012
22
Affective disorders among patients with borderline personality disorder. (23236411)
2012
23
Normal mind-reading capacity but higher response confidence in borderline personality disorder patients. (22624737)
2012
24
Response inhibition deficits in unaffected first-degree relatives of patients with borderline personality disorder. (22612574)
2012
25
Risk factors affecting children of mothers with borderline personality disorder: Comment on Stepp, Whalen, Pilkonis, Hipwell, and Levine (2011). (22448863)
2012
26
Sleep disturbances and circadian CLOCK genes in borderline personality disorder. (22806005)
2012
27
Affect regulation and psychopathology in women with borderline personality disorder. (23171744)
2012
28
Prospective predictors of suicidal behavior in borderline personality disorder at 6-year follow-up. (22549208)
2012
29
Organizing awareness and increasing emotion regulation: revising chair work in emotion-focused therapy for borderline personality disorder. (22369168)
2012
30
Implicit self-esteem in borderline personality and depersonalization disorder. (22493585)
2012
31
'I think we're all guinea pigs really': a qualitative study of medication and borderline personality disorder. (22070628)
2012
32
Social cognition in borderline personality disorder. (23335877)
2012
33
The effect of ostracism upon mood in youth with borderline personality disorder. (22023305)
2011
34
Family study of borderline personality disorder and its sectors of psychopathology. (21727257)
2011
35
Emotion regulation and substance use frequency in women with substance dependence and borderline personality disorder receiving dialectical behavior therapy. (21091162)
2011
36
Dissociation predicts poor response to Dialectial Behavioral Therapy in female patients with Borderline Personality Disorder. (21838560)
2011
37
Medication for borderline personality disorder: a survey at a secure hospital. (22122000)
2011
38
Borderline personality disorder. (21998894)
2011
39
Psychopathology, childhood trauma, and personality traits in patients with borderline personality disorder and their sisters. (21838561)
2011
40
Impact of borderline personality disorder on bulimia nervosa. (19016090)
2008
41
Dialectical behavior therapy for clients with binge-eating disorder or bulimia nervosa and borderline personality disorder. (18348281)
2008
42
Axis I dissociative disorder comorbidity in borderline personality disorder and reports of childhood trauma. (17107251)
2006
43
Self-stigma in women with borderline personality disorder and women with social phobia. (17041289)
2006
44
Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder. (17000047)
2006
45
The impact of borderline personality disorder on 12-month outcomes for the treatment of heroin dependence. (16042642)
2005
46
Effects of borderline personality disorder features and a family history of alcohol or drug dependence on P300 in adolescents. (15172136)
2004
47
Functional impairment in patients with schizotypal, borderline, avoidant, or obsessive-compulsive personality disorder. (11823271)
2002
48
A family study of outpatients with borderline personality disorder and no history of mood disorder. (11019745)
2000
49
Object relations, defensive operations, and affective states in narcissistic, borderline, and antisocial personality disorder. (1512679)
1992
50
Multiple personality disorder and borderline personality disorder. (2400015)
1990

Genetic Variations for Borderline Personality Disorder

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Expression for genes affiliated with Borderline Personality Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Borderline Personality Disorder

Search GEO for disease gene expression data for Borderline Personality Disorder.

Pathways for genes affiliated with Borderline Personality Disorder

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 53Reactome, 51QIAGEN
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Pathways related to Borderline Personality Disorder according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2TPH1, TPH2
2
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10.2TPH2, TPH1
3
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10.2TPH1, TPH2
4
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10.2MAOA, COMT
5
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10.1TPH2, TPH1, MAOA
6
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10.1TPH2, TPH1, MAOA
7
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9.4BDNF, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
8
Hide members
9.3SLC6A4, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
9
Hide members
9.3HTR1B, HTR1A, HTR2A, HTR1D, CRH, PRL
109.2BDNF, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
11
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9.2COMT, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
12
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9.1HTR1B, HTR1A, HTR2A, HTR1D, CRH, PRL

Compounds for genes affiliated with Borderline Personality Disorder

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Borderline Personality Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 287)
idCompoundScoreTop Affiliating Genes
1m-chlorophenylpiperazine4410.0HTR2A, PRL, HTR3A, HTR1A, SLC6A4
2naratriptan44 28 1112.0HTR2A, HTR1A, HTR1B, HTR1D, MAOA
3cyanopindolol44 2810.9HTR2A, HTR1D, HTR1A, HTR3A, HTR1B
4mcpp449.9HTR1A, HTR1B, SLC6A4, HTR3A, HTR2A, PRL
5pindolol44 28 1111.9SLC6A4, PRL, HTR2A, HTR3A, HTR1A, HTR1B
62-methyl-5-ht44 2810.9HTR1A, HTR1B, HTR3A, HTR2A, HTR1D
7mdma449.9PRL, HTR1A, MAOA, SLC6A4, TPH1
8ru 2496928 4410.9HTR1B, HTR1D, HTR2A, HTR3A, HTR1A
95-carboxamidotryptamine449.9HTR1D, HTR3A, HTR1A, HTR1B, HTR2A
10ipsapirone44 2810.9HTR1D, PRL, HTR2A, HTR3A, HTR1B, HTR1A
11methysergide44 28 1111.8HTR1B, MAOA, HTR1D, HTR2A, HTR3A, HTR1A
12mhpg449.8COMT, BDNF, CRH, PRL, SLC6A4, MAOA
13mirtazapine49 44 1111.8PRL, CRH, HTR2A, SLC6A4, HTR3A, TPH2
14zotepine44 2810.8HTR1D, HTR2A, PRL, HTR1B, HTR1A, HTR3A
15fluvoxamine44 49 1111.8HTR1A, HTR3A, HTR2A, MAOA, SLC6A4, TPH1
16ritanserin28 4410.8HTR3A, PRL, HTR1D, HTR2A, HTR1A, HTR1B
17dihydroergotamine28 44 1111.8HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
18metergoline44 2810.8HTR1B, HTR3A, HTR1A, HTR1D, HTR2A, PRL
19sumatriptan44 28 59 49 11 2414.8HTR1A, HTR3A, HTR2A, HTR1D, HTR1B, MAOA
20pergolide28 44 1111.8HTR1A, HTR1B, HTR2A, HTR1D, PRL, COMT
215-hydroxytryptophan449.8HTR1A, HTR3A, HTR2A, CRH, PRL, SLC6A4
22homovanillic acid44 2410.8TPH1, COMT, BDNF, CRH, PRL, MAOA
23venlafaxine49 44 11 2412.8BDNF, HTR1B, HTR1A, HTR3A, HTR2A, SLC6A4
24cabergoline28 44 1111.8HTR1B, PRL, HTR1D, HTR2A, HTR1A, COMT
25clomipramine44 49 1111.7HTR1A, HTR3A, HTR2A, CRH, PRL, MAOA
26aripiprazole28 49 44 11 2413.7HTR1B, HTR3A, HTR2A, HTR1D, PRL, HTR1A
27ketanserin28 4410.7HTR2A, HTR3A, HTR1A, HTR1B, BDNF, HTR1D
28ziprasidone49 28 44 1112.7PRL, HTR1D, HTR3A, HTR1A, HTR1B, HTR2A
29terguride28 4410.7HTR1D, HTR2A, HTR1A, HTR1B, PRL
30pramipexole44 49 28 1112.7PRL, HTR1D, HTR2A, COMT, HTR1A, HTR1B
31apomorphine44 28 1111.7COMT, HTR2A, HTR1B, HTR1D, PRL, HTR1A
32yohimbine44 28 2 1112.7HTR2A, HTR1D, HTR1A, HTR3A, CRH, HTR1B
33citalopram49 44 11 2412.6TPH1, SLC6A4, BDNF, HTR1A, HTR3A, PRL
34quetiapine44 49 28 11 2413.6BDNF, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
35levodopa44 1110.5HTR1B, MAOA, COMT, BDNF, TPH1, PRL
36antidepressants499.5BDNF, HTR2A, TPH1, TPH2, HTR1A
37amine449.5TPH1, SLC6A4, MAOA, HTR1D, HTR3A, HTR1B
38maoa449.5COMT, MAOA, BDNF, HTR1B, HTR1A, HTR2A
39olanzapine49 44 28 11 2413.5COMT, BDNF, HTR1B, HTR1A, HTR3A, HTR2A
40desipramine44 49 1111.5HTR1A, HTR2A, BDNF, CRH, MAOA, SLC6A4
41fenfluramine28 44 1111.5TPH2, TPH1, HTR1B, HTR1A, HTR3A, HTR2A
42risperidone28 44 49 59 11 2414.4SLC6A4, PRL, HTR1D, HTR2A, HTR3A, HTR1A
43clozapine44 28 49 1112.3COMT, BDNF, HTR1B, HTR1A, HTR3A, HTR2A
44paroxetine44 49 28 1112.3PRL, MAOA, SLC6A4, TPH1, HTR2A, COMT
45methiothepin44 2810.3HTR1B, HTR1A, HTR2A, HTR1D, HTR3A
46haloperidol44 28 2 49 1113.2HTR1A, BDNF, HTR3A, HTR1D, PRL, SLC6A4
47fluoxetine49 44 28 1112.1BDNF, HTR1B, HTR1A, HTR3A, HTR2A, CRH
48norepinephrine44 11 2411.0COMT, TPH1, SLC6A4, BDNF, HTR1A, HTR3A
49dopamine44 28 11 2412.0COMT, BDNF, HTR1A, HTR3A, HTR2A, HTR1D
505-hydroxytryptamine448.9HTR1B, HTR1A, HTR3A, HTR2A, HTR1D, CRH

GO Terms for genes affiliated with Borderline Personality Disorder

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16Gene Ontology
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Cellular components related to Borderline Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.0SLC6A4, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
2plasma membraneGO:0058868.7HTR1B, HTR1A, HTR3A, HTR2A, HTR1D, FLNA

Biological processes related to Borderline Personality Disorder according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase-inhibiting serotonin receptor signaling pathwayGO:00719810.5HTR1B, HTR1A
2serotonin biosynthetic processGO:04242710.5TPH1, TPH2
3aromatic amino acid family metabolic processGO:00907210.5TPH1, TPH2
4regulation of serotonin secretionGO:01406210.4HTR1A, CRH
5dopamine catabolic processGO:04242010.4COMT, MAOA
6regulation of hormone secretionGO:04688310.4HTR1A, HTR2A
7indolalkylamine biosynthetic processGO:04621910.4TPH2, TPH1
8response to immobilization stressGO:03590210.4CRH, TPH1
9sperm ejaculationGO:04271310.4AVPR1A, SLC6A4
10neurotransmitter catabolic processGO:04213510.3MAOA, COMT
11serotonin receptor signaling pathwayGO:00721010.3HTR1A, HTR3A, HTR2A
12negative regulation of synaptic transmission, glutamatergicGO:05196710.2HTR2A, HTR1B
13parturitionGO:00756710.2PRL, CRH
14circadian rhythmGO:00762310.2TPH2, TPH1, SLC6A4, PRL
15vasoconstrictionGO:04231010.2HTR1B, HTR1A, HTR1D, SLC6A4
16neurotransmitter biosynthetic processGO:04213610.2MAOA, COMT
17regulation of behaviorGO:05079510.1HTR1D, HTR2A, HTR1A, HTR1B
18response to estrogen stimulusGO:04362710.1TPH2, CRH, BGLAP
19regulation of dopamine secretionGO:01405910.1HTR2A, HTR1B
20response to ethanolGO:04547110.0PRL, CRH, HTR1B, BGLAP
21female pregnancyGO:0075659.9COMT, CRH, PRL
22bone remodelingGO:0468499.9TPH1, HTR1B
23response to drugGO:0424939.7COMT, BGLAP, HTR2A, CRH, PRL, SLC6A4
24synaptic transmissionGO:0072689.6COMT, HTR1B, HTR3A, HTR2A, HTR1D, CRH

Molecular functions related to Borderline Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tryptophan 5-monooxygenase activityGO:00451010.2TPH2, TPH1
2serotonin receptor activityGO:0049939.5HTR1D, HTR2A, HTR3A, HTR1A, HTR1B
3serotonin bindingGO:0513789.5HTR1B, HTR3A, HTR2A, HTR1D

Products for genes affiliated with Borderline Personality Disorder

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  • Antibodies
  • Proteins
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Sources for Borderline Personality Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet