MCID: BRD004
MIFTS: 53

Borderline Personality Disorder malady

Summaries for Borderline Personality Disorder

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods.

MalaCards: Borderline Personality Disorder is related to personality disorder and bipolar disorder. An important gene associated with Borderline Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Monoamine GPCRs and Tryptophan metabolism. The compounds m-chlorophenylpiperazine and naratriptan have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and amygdala, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Wikipedia:63 Borderline personality disorder (BPD) (called emotionally unstable personality disorder, emotional... more...

Aliases & Classifications for Borderline Personality Disorder

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
See all sources

Aliases & Descriptions:

borderline personality disorder 8 10 44 60


External Ids:

Disease Ontology8 DOID:10930
MeSH34 D001883
SNOMED-CT56 192488005, 20010003
ICD9CM27 301.83

Related Diseases for Borderline Personality Disorder

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Borderline Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder32.2HTR1B, MAOA, TTF2, SLC6A4, TPH1, TPH2
2bipolar disorder31.1SLC6A4, HTR2A, HTR3A
3bulimia nervosa30.8COMT, BDNF, HTR1B, HTR3A, HTR2A, MAOA
4substance dependence30.7TPH1, SLC6A4, COMT
5antisocial personality disorder30.6HTR1B, HTR2A, MAOA, TTF2, SLC6A4
6attention deficit hyperactivity disorder30.6COMT, BDNF, HTR1B, HTR2A, MAOA, SLC6A4
7mood disorder30.6HTR2A, CRH, MAOA, SLC6A4, TPH1, TPH2
8eating disorder30.6SLC6A4
9anorexia nervosa30.5BDNF, HTR2A
10conduct disorder30.5COMT, MAOA, TTF2, SLC6A4
11anxiety disorder30.5BDNF, HTR3A, CRH, MAOA, SLC6A4, TPH1
12drug dependence30.3SLC6A4, MAOA
13substance abuse30.3SLC6A4, CRH
14obsessive-compulsive personality disorder30.3CLPS, SLC6A4
15schizotypal personality disorder30.3COMT, FLNA
16schizophrenia30.3COMT, HTR2A
17obsessive-compulsive disorder30.3TPH2, TPH1, SLC6A4, COMT, BDNF, HTR1B
18nicotine dependence30.1SLC6A4
19cocaine dependence30.1SLC6A4
20melancholia30.1CRH, MAOA
21dysthymic disorder30.1HTR2A, MAOA
22panic disorder30.1HTR1A, HTR3A, CRH, SLC6A4
23social phobia30.1COMT, HTR1A, HTR3A, MAOA, SLC6A4
24alcohol dependence30.1MAOA, SLC6A4, CRH, HTR2A, HTR1B
25polycystic ovary syndrome30.1PRL, CRH
26obesity30.1COMT, HTR1A, HTR2A, CRH, MAOA, CLPS
27psychotic disorder30.1COMT, BDNF, HTR1A, HTR3A, HTR2A, PRL
28major depressive disorder10.7
29dependent personality disorder10.7
30sexual disorder10.6
31dissociative disorder10.5
32sleep disorder10.5
33pain disorder10.5
34avoidant personality disorder10.4
35somatoform disorder10.4
36multiple personality disorder10.4
37heroin dependence10.4
38post-traumatic stress disorder10.4
39alexithymia10.3
40narcissistic personality disorder10.2
41cerebritis10.2
42somatization disorder10.2
43rumination disorder10.2
44impulse control disorder10.2
45prolactinoma10.1
46cannabis dependence10.1
47expressive language disorder10.1
48schizophreniform disorder10.1
49hypochondriasis10.1
50asperger syndrome10.1

Graphical network of the top 20 diseases related to Borderline Personality Disorder:



Diseases related to borderline personality disorder

Clinical Features for Borderline Personality Disorder

About this section

Drugs & Therapeutics for Borderline Personality Disorder

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Borderline Personality Disorder

Drug clinical trials:

Search ClinicalTrials for Borderline Personality Disorder

Search NIH Clinical Center for Borderline Personality Disorder

Search CenterWatch for Borderline Personality Disorder

Genetic Tests for Borderline Personality Disorder

About this section

Anatomical Context for Borderline Personality Disorder

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Borderline Personality Disorder:

32
Bone, Brain, Amygdala, Testes, Pituitary, Cortex, Ovary, Prefrontal cortex

Animal Models for Borderline Personality Disorder or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Borderline Personality Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.3HTR3A, HTR2A, CRH, PRL, AVPR1A, SLC6A4
2MP:00053859.0COMT, HTR1B, HTR1A, FLNA, MAOA, AVPR1A
3MP:00107718.8BDNF, HTR3A, CRH, PRL, CLPS, SLC6A4
4MP:00036318.6COMT, BDNF, HTR1A, HTR3A, CRH, FLNA
5MP:00053768.4COMT, BDNF, HTR1A, HTR3A, CRH, FLNA
6MP:00053868.1TPH2, COMT, BDNF, HTR1B, HTR1A, HTR3A

Publications for Borderline Personality Disorder

About this section
Sources:
50PubMed
See all sources

Articles related to Borderline Personality Disorder:

(show top 50)    (show all 585)
idTitleAuthorsYear
1
Evidence base and components of brief admission as an intervention for patients with borderline personality disorder: a review of the literature. (24387616)
2014
2
Getting the word out about treating borderline personality disorder: an online information resource. (23334680)
2013
3
"It's us that have to deal with it seven days a week": carers and borderline personality disorder. (23054157)
2013
4
Is low affect consciousness related to the severity of psychopathology? A cross-sectional study of patients with avoidant and borderline personality disorder. (22998844)
2013
5
Prenatal adversity: a risk factor in borderline personality disorder? (23217579)
2013
6
The relationship between borderline personality disorder and major depression in later life: acute versus temperamental symptoms. (23567384)
2013
7
Diazepam Binding Inhibitor and Dehydroepiandrosterone Sulphate Plasma Levels in Borderline Personality Disorder Adolescents. (24401326)
2013
8
Phenomenology of borderline personality disorder: the role of race and socioeconomic status. (24284636)
2013
9
Personality dimensions and working alliance in subjects with borderline personality disorder. (23084803)
2013
10
Post-traumatic stress disorder and the outcome of dialectical behaviour therapy for borderline personality disorder. (24343961)
2013
11
Body image disturbance in patients with borderline personality disorder: impact of eating disorders and perceived childhood sexual abuse. (23375838)
2013
12
Impulsivity in borderline personality disorder: a matter of disturbed impulse control or a facet of emotional dysregulation? (23424747)
2013
13
Borderline personality disorder symptoms and treatment seeking over the past 12 months: an investigation using the national comorbidity survey-replication (NCS-R). (24229759)
2013
14
Developmental trajectories to male borderline personality disorder. (23795759)
2013
15
Prospective risk factors for suicide attempts in a treated sample of patients with borderline personality disorder. (23442897)
2013
16
Comorbid Bipolar Disorder and Borderline Personality Disorder and History of Suicide Attempts. (24256102)
2013
17
Emotional regulation and bodily sensation: interoceptive awareness is intact in borderline personality disorder. (22928847)
2013
18
Factors related to dropout from treatment in two outpatient treatments for borderline personality disorder. (23718760)
2013
19
Emotions and Memory in Borderline Personality Disorder. (24355827)
2013
20
Stress regulation and incision in borderline personality disorder--a pilot study modeling cutting behavior. (22867510)
2012
21
Development of borderline personality disorder in adolescence and young adulthood: introduction to the special section. (22116635)
2012
22
Borderline personality disorder in adolescents: evidence in support of the Childhood Interview for DSM-IV Borderline Personality Disorder in a sample of adolescent inpatients. (22300904)
2012
23
Efficacy of extended-release divalproex combined with "condensed" dialectical behavior therapy for individuals with borderline personality disorder. (23145381)
2012
24
Effects of the dialectical behavioral therapy-mindfulness module on attention in patients with borderline personality disorder. (22225697)
2012
25
The course of anxiety disorders other than PTSD in patients with borderline personality disorder and Axis II comparison subjects: a 10-year follow-up study. (23013347)
2012
26
Conceptual changes to the definition of borderline personality disorder proposed for DSM-5. (21875165)
2012
27
Gender differences in a clinical sample of patients with borderline personality disorder. (22686225)
2012
28
Amygdalar volume in borderline personality disorder with and without comorbid post-traumatic stress disorder: a meta-analysis. (22789064)
2012
29
Interpersonal patterns in borderline personality disorder. (22867508)
2012
30
Sustained unemployment in psychiatric outpatients with bipolar depression compared to major depressive disorder with comorbid borderline personality disorder. (23057759)
2012
31
Case of borderline personality disorder in a 23 year old male with history of Klinefelter syndrome. (22813671)
2012
32
The course of dysphoric affective and cognitive states in borderline personality disorder: a 10-year follow-up study. (22326877)
2012
33
Relationships between childhood maltreatment, parenting style, and borderline personality disorder criteria. (23013341)
2012
34
Persistent antinociception through repeated self-injury in patients with borderline personality disorder. (22197694)
2012
35
Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression. (22444624)
2012
36
The Course of Positive Affective and Cognitive States in Borderline Personality Disorder: A 10-year Follow-up Study. (23606922)
2012
37
The self-image in borderline personality disorder: an in-depth qualitative research study. (21838566)
2011
38
Predisposition for borderline personality disorder with comorbid major depression is associated with that for polycystic ovary syndrome in female Japanese population. (22090801)
2011
39
Do patients with borderline personality disorder in primary care gain access to mental health services? (21731848)
2011
40
Childhood traumatization by primary caretaker and affect dysregulation in patients with borderline personality disorder and somatoform disorder. (22893813)
2011
41
Positive affective and cognitive states in borderline personality disorder. (22217230)
2011
42
Prescribing topiramate in patients with borderline personality disorder and a history of anorexia nervosa: a case report. (21977342)
2011
43
A comparison of UK and US guidelines for drug treatment in borderline personality disorder. (22026496)
2011
44
Alexithymic traits and facial emotion recognition in borderline personality disorder. (21968640)
2011
45
Barriers to implementing the clinical guideline on borderline personality disorder in the Netherlands. (22211222)
2011
46
Depressive-type emotional response pattern in impulsive-aggressive patients with borderline personality disorder. (21807413)
2011
47
The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in female patients with borderline personality disorder (BPD). (19906087)
2010
48
Exploratory factor analysis of borderline personality disorder criteria in hospitalized adolescents. (16490567)
2006
49
5-HT1A dysfunction in borderline personality disorder. (12171388)
2002
50
Rhinestones and gold-dust: attention deficit, borderline personality, or mood disorder? (7646680)
1995

Genetic Variations for Borderline Personality Disorder

About this section

Expression for genes affiliated with Borderline Personality Disorder

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Borderline Personality Disorder

Search GEO for disease gene expression data for Borderline Personality Disorder.

Pathways for genes affiliated with Borderline Personality Disorder

About this section
Sources:
37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 53Reactome, 51QIAGEN
See all sources

Pathways related to Borderline Personality Disorder according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2TPH1, TPH2
2
Hide members
10.2TPH2, TPH1
3
Hide members
10.2TPH1, TPH2
4
Hide members
10.2MAOA, COMT
5
Hide members
10.1TPH2, TPH1, MAOA
6
Hide members
10.1TPH2, TPH1, MAOA
7
Hide members
9.4BDNF, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
8
Hide members
9.3SLC6A4, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
9
Hide members
9.3HTR1B, HTR1A, HTR2A, HTR1D, CRH, PRL
109.2BDNF, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
11
Hide members
9.2COMT, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
12
Hide members
9.1HTR1B, HTR1A, HTR2A, HTR1D, CRH, PRL

Compounds for genes affiliated with Borderline Personality Disorder

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Borderline Personality Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 287)
idCompoundScoreTop Affiliating Genes
1m-chlorophenylpiperazine4410.0HTR2A, PRL, HTR3A, HTR1A, SLC6A4
2naratriptan44 28 1112.0HTR2A, HTR1A, HTR1B, HTR1D, MAOA
3cyanopindolol44 2810.9HTR2A, HTR1D, HTR1A, HTR3A, HTR1B
4mcpp449.9HTR1A, HTR1B, SLC6A4, HTR3A, HTR2A, PRL
5pindolol44 28 1111.9SLC6A4, PRL, HTR2A, HTR3A, HTR1A, HTR1B
62-methyl-5-ht44 2810.9HTR1A, HTR1B, HTR3A, HTR2A, HTR1D
7mdma449.9PRL, HTR1A, MAOA, SLC6A4, TPH1
8ru 2496928 4410.9HTR1B, HTR1D, HTR2A, HTR3A, HTR1A
95-carboxamidotryptamine449.9HTR1D, HTR3A, HTR1A, HTR1B, HTR2A
10ipsapirone44 2810.9HTR1D, PRL, HTR2A, HTR3A, HTR1B, HTR1A
11methysergide44 28 1111.8HTR1B, MAOA, HTR1D, HTR2A, HTR3A, HTR1A
12mhpg449.8COMT, BDNF, CRH, PRL, SLC6A4, MAOA
13mirtazapine49 44 1111.8PRL, CRH, HTR2A, SLC6A4, HTR3A, TPH2
14zotepine44 2810.8HTR1D, HTR2A, PRL, HTR1B, HTR1A, HTR3A
15fluvoxamine44 49 1111.8HTR1A, HTR3A, HTR2A, MAOA, SLC6A4, TPH1
16ritanserin28 4410.8HTR3A, PRL, HTR1D, HTR2A, HTR1A, HTR1B
17dihydroergotamine28 44 1111.8HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
18metergoline44 2810.8HTR1B, HTR3A, HTR1A, HTR1D, HTR2A, PRL
19sumatriptan44 28 59 49 11 2414.8HTR1A, HTR3A, HTR2A, HTR1D, HTR1B, MAOA
20pergolide28 44 1111.8HTR1A, HTR1B, HTR2A, HTR1D, PRL, COMT
215-hydroxytryptophan449.8HTR1A, HTR3A, HTR2A, CRH, PRL, SLC6A4
22homovanillic acid44 2410.8TPH1, COMT, BDNF, CRH, PRL, MAOA
23venlafaxine49 44 11 2412.8BDNF, HTR1B, HTR1A, HTR3A, HTR2A, SLC6A4
24cabergoline28 44 1111.8HTR1B, PRL, HTR1D, HTR2A, HTR1A, COMT
25clomipramine44 49 1111.7HTR1A, HTR3A, HTR2A, CRH, PRL, MAOA
26aripiprazole28 49 44 11 2413.7HTR1B, HTR3A, HTR2A, HTR1D, PRL, HTR1A
27ketanserin28 4410.7HTR2A, HTR3A, HTR1A, HTR1B, BDNF, HTR1D
28ziprasidone49 28 44 1112.7PRL, HTR1D, HTR3A, HTR1A, HTR1B, HTR2A
29terguride28 4410.7HTR1D, HTR2A, HTR1A, HTR1B, PRL
30pramipexole44 49 28 1112.7PRL, HTR1D, HTR2A, COMT, HTR1A, HTR1B
31apomorphine44 28 1111.7COMT, HTR2A, HTR1B, HTR1D, PRL, HTR1A
32yohimbine44 28 2 1112.7HTR2A, HTR1D, HTR1A, HTR3A, CRH, HTR1B
33citalopram49 44 11 2412.6TPH1, SLC6A4, BDNF, HTR1A, HTR3A, PRL
34quetiapine44 49 28 11 2413.6BDNF, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
35levodopa44 1110.5HTR1B, MAOA, COMT, BDNF, TPH1, PRL
36antidepressants499.5BDNF, HTR2A, TPH1, TPH2, HTR1A
37amine449.5TPH1, SLC6A4, MAOA, HTR1D, HTR3A, HTR1B
38maoa449.5COMT, MAOA, BDNF, HTR1B, HTR1A, HTR2A
39olanzapine49 44 28 11 2413.5COMT, BDNF, HTR1B, HTR1A, HTR3A, HTR2A
40desipramine44 49 1111.5HTR1A, HTR2A, BDNF, CRH, MAOA, SLC6A4
41fenfluramine28 44 1111.5TPH2, TPH1, HTR1B, HTR1A, HTR3A, HTR2A
42risperidone28 44 49 59 11 2414.4SLC6A4, PRL, HTR1D, HTR2A, HTR3A, HTR1A
43clozapine44 28 49 1112.3COMT, BDNF, HTR1B, HTR1A, HTR3A, HTR2A
44paroxetine44 49 28 1112.3PRL, MAOA, SLC6A4, TPH1, HTR2A, COMT
45methiothepin44 2810.3HTR1B, HTR1A, HTR2A, HTR1D, HTR3A
46haloperidol44 28 2 49 1113.2HTR1A, BDNF, HTR3A, HTR1D, PRL, SLC6A4
47fluoxetine49 44 28 1112.1BDNF, HTR1B, HTR1A, HTR3A, HTR2A, CRH
48norepinephrine44 11 2411.0COMT, TPH1, SLC6A4, BDNF, HTR1A, HTR3A
49dopamine44 28 11 2412.0COMT, BDNF, HTR1A, HTR3A, HTR2A, HTR1D
505-hydroxytryptamine448.9HTR1B, HTR1A, HTR3A, HTR2A, HTR1D, CRH

GO Terms for genes affiliated with Borderline Personality Disorder

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Borderline Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.0SLC6A4, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
2plasma membraneGO:0058868.7HTR1B, HTR1A, HTR3A, HTR2A, HTR1D, FLNA

Biological processes related to Borderline Personality Disorder according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase-inhibiting serotonin receptor signaling pathwayGO:00719810.5HTR1B, HTR1A
2serotonin biosynthetic processGO:04242710.5TPH1, TPH2
3aromatic amino acid family metabolic processGO:00907210.5TPH1, TPH2
4regulation of serotonin secretionGO:01406210.4HTR1A, CRH
5dopamine catabolic processGO:04242010.4COMT, MAOA
6regulation of hormone secretionGO:04688310.4HTR1A, HTR2A
7indolalkylamine biosynthetic processGO:04621910.4TPH2, TPH1
8response to immobilization stressGO:03590210.4CRH, TPH1
9sperm ejaculationGO:04271310.4AVPR1A, SLC6A4
10neurotransmitter catabolic processGO:04213510.3MAOA, COMT
11serotonin receptor signaling pathwayGO:00721010.3HTR1A, HTR3A, HTR2A
12negative regulation of synaptic transmission, glutamatergicGO:05196710.2HTR2A, HTR1B
13parturitionGO:00756710.2PRL, CRH
14circadian rhythmGO:00762310.2TPH2, TPH1, SLC6A4, PRL
15vasoconstrictionGO:04231010.2HTR1B, HTR1A, HTR1D, SLC6A4
16neurotransmitter biosynthetic processGO:04213610.2MAOA, COMT
17regulation of behaviorGO:05079510.1HTR1D, HTR2A, HTR1A, HTR1B
18response to estrogen stimulusGO:04362710.1TPH2, CRH, BGLAP
19regulation of dopamine secretionGO:01405910.1HTR2A, HTR1B
20response to ethanolGO:04547110.0PRL, CRH, HTR1B, BGLAP
21female pregnancyGO:0075659.9COMT, CRH, PRL
22bone remodelingGO:0468499.9TPH1, HTR1B
23response to drugGO:0424939.7COMT, BGLAP, HTR2A, CRH, PRL, SLC6A4
24synaptic transmissionGO:0072689.6COMT, HTR1B, HTR3A, HTR2A, HTR1D, CRH

Molecular functions related to Borderline Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tryptophan 5-monooxygenase activityGO:00451010.2TPH2, TPH1
2serotonin receptor activityGO:0049939.5HTR1D, HTR2A, HTR3A, HTR1A, HTR1B
3serotonin bindingGO:0513789.5HTR1B, HTR3A, HTR2A, HTR1D

Products for genes affiliated with Borderline Personality Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Borderline Personality Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet