MCID: BRD004
MIFTS: 47

Borderline Personality Disorder malady

Mental diseases category
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Summaries for Borderline Personality Disorder

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Disease Ontology:8 A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods.

MalaCards based summary: Borderline Personality Disorder is related to personality disorder and substance abuse. An important gene associated with Borderline Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Monoamine Transport and tryptophan utilization II. The compounds carbon-11 and p-chloroamphetamine have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and bone, and related mouse phenotypes are muscle and cardiovascular system.

Wikipedia:65 Borderline personality disorder (BPD) (called emotionally unstable personality disorder, emotional... more...

Aliases & Classifications for Borderline Personality Disorder

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Borderline Personality Disorder, Aliases & Descriptions:

Name: Borderline Personality Disorder 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:10930
ICD9CM27 301.83
SNOMED-CT57 192488005, 20010003
MeSH34 D001883

Related Diseases for Borderline Personality Disorder

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Diseases related to Borderline Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder31.4TTF2, TPH1, HTR1B, MAOA, SLC6A4
2substance abuse31.1SLC6A4
3substance dependence31.0SLC6A4, TPH1
4bipolar disorder30.9TPH1, MAOA, SLC6A4
5melancholia30.8MAOA
6drug dependence30.7SLC6A4, MAOA
7bulimia nervosa30.7HTR1B, MAOA, SLC6A4
8conduct disorder30.6TTF2, MAOA, SLC6A4
9intermittent explosive disorder30.6HTR1B
10attention deficit hyperactivity disorder30.5SLC6A4, MAOA, HTR1B
11anxiety disorder30.5TPH1, MAOA, SLC6A4
12social phobia30.5SLC6A4, MAOA
13anorexia nervosa30.3SLC6A4, MAOA, TPH1
14generalized anxiety disorder30.1TPH1, MAOA, SLC6A4
15antisocial personality disorder30.1TTF2, HTR1B, MAOA, SLC6A4
16mood disorder30.1TPH1, HTR1B, MAOA, SLC6A4
17alcohol dependence30.0SLC6A4, MAOA, HTR1B
18panic disorder29.9TTF2, TPH1, MAOA, SLC6A4
19schizophrenia29.7TTF2, TPH1, HTR1B, MAOA, SLC6A4
20major depressive disorder10.6
21somatoform disorder10.5
22post-traumatic stress disorder10.5
23heroin dependence10.5
24multiple personality disorder10.5
25eating disorder10.5
26alexithymia10.4
27premature ejaculation10.4SLC6A4
28serotonin syndrome10.3MAOA
29narcissistic personality disorder10.3
30schizotypal personality disorder10.3
31cerebritis10.3
32dissociative disorder10.3
33blindness10.3
34endogenous depression10.2MAOA, SLC6A4
35obesity10.2
36polycystic ovary syndrome10.2
37bipolar i disorder10.2
38cannabis dependence10.2
39avoidant personality disorder10.2
40somatization disorder10.2
41oppositional defiant disorder10.2
42cocaine dependence10.2
43prolactinoma10.2
44hypochondriasis10.2
45asperger syndrome10.2
46dysthymic disorder10.2
47obsessive-compulsive personality disorder10.2
48neuronitis10.2
49schizophreniform disorder10.2
50dissociative amnesia10.2

Graphical network of the top 20 diseases related to Borderline Personality Disorder:



Diseases related to borderline personality disorder

Symptoms for Borderline Personality Disorder

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Drugs & Therapeutics for Borderline Personality Disorder

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Drug clinical trials:

Search ClinicalTrials for Borderline Personality Disorder

Search NIH Clinical Center for Borderline Personality Disorder

Genetic Tests for Borderline Personality Disorder

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Anatomical Context for Borderline Personality Disorder

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MalaCards organs/tissues related to Borderline Personality Disorder:

32
Brain, Amygdala, Bone, Cortex, Testes, Pituitary, Ovary, Prefrontal cortex

Animal Models for Borderline Personality Disorder or affiliated genes

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MGI Mouse Phenotypes related to Borderline Personality Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.1SLC6A4, HTR1B, TPH1, AVPR1A
2MP:00053857.4SLC6A4, MAOA, HTR1B, TPH1, AVPR1A
3MP:00053867.2AVPR1A, TPH1, HTR1B, MAOA, SLC6A4

Publications for Borderline Personality Disorder

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Articles related to Borderline Personality Disorder:

(show top 50)    (show all 578)
idTitleAuthorsYear
1
Safety and drinking outcomes among patients with comorbid alcohol dependence and borderline personality disorder treated with high-dose baclofen: a comparative cohort study. (25356633)
2014
2
Sexual Feelings Toward the Therapist Among Patients with Borderline Personality Disorder: A Case of Erotomanic Delusional Disorder. (25391585)
2014
3
Day hospital Mentalization-based treatment versus intensive outpatient Mentalization-based treatment for patients with severe borderline personality disorder: protocol of a multicentre randomized clinical trial. (25403144)
2014
4
Emotional cascades as prospective predictors of dysregulated behaviors in borderline personality disorder. (23046043)
2013
5
Distinguishing bipolar II depression from major depressive disorder with comorbid borderline personality disorder: demographic, clinical, and family history differences. (24107761)
2013
6
Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder. (22404662)
2013
7
A Further Validation of the Minnesota Borderline Personality Disorder Scale. (24364505)
2013
8
Getting the word out about treating borderline personality disorder: an online information resource. (23334680)
2013
9
Resident didactic education in borderline personality disorder: is it sufficient? (23820919)
2013
10
Trait anxiety modulates fronto-limbic processing of emotional interference in borderline personality disorder. (23459637)
2013
11
Psychological pathways from childhood sexual and physical abuse to HIV/sexually transmitted infection outcomes among homeless women: the role of posttraumatic stress disorder and borderline personality disorder symptoms. (23180873)
2013
12
Re-offending in forensic patients released from secure care: the role of antisocial/borderline personality disorder co-morbidity, substance dependence and severe childhood conduct disorder. (23371302)
2013
13
Symptoms of borderline personality disorder predict interpersonal (but not independent) stressful life events in a community sample of older adults. (23713502)
2013
14
"It's us that have to deal with it seven days a week": carers and borderline personality disorder. (23054157)
2013
15
Efficacy of omega-3 fatty acids in the treatment of borderline personality disorder: A study of the association with valproic acid. (24196948)
2013
16
Temperamental patterns in female adolescents with borderline personality disorder. (23364119)
2013
17
Personality disorders as maladaptive, extreme variants of normal personality: borderline personality disorder and neuroticism in a substance using sample. (24044664)
2013
18
Borderline personality disorder and emotional intelligence. (23364117)
2013
19
Oxytocin influences avoidant reactions to social threat in adults with borderline personality disorder. (23950057)
2013
20
Multimodal examination of emotion regulation difficulties as a function of co-occurring avoidant personality disorder among women with borderline personality disorder. (24378158)
2013
21
Alexithymia as a mediator between attachment and the development of borderline personality disorder in adolescence. (23013337)
2012
22
Gender Differences in a Clinical Sample of Patients with Borderline Personality Disorder. (22494170)
2012
23
Management of borderline personality disorder. (23027916)
2012
24
Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients. (22633012)
2012
25
Borderline Personality Disorder (BPD) diagnosis with the self-report Personality Diagnostic Questionnairea894+(PDQ-4+): confirmation of the 3-factor structure. (22508070)
2012
26
Identity-related autobiographical memories and cultural life scripts in patients with Borderline Personality Disorder. (22356875)
2012
27
An Empirical Examination of Gunderson's Proposed Revision of the Diagnostic Algorithm for Borderline Personality Disorder. (22984857)
2012
28
Affective startle modulation in incarcerated women with borderline personality disorder features. (22452769)
2012
29
Patient factors predicting early dropout from psychiatric outpatient care for borderline personality disorder. (22503328)
2012
30
Stress Regulation and Incision in Borderline Personality Disorder-A Pilot Study Modeling Cutting Behavior. (22616773)
2012
31
Risky decision-making in borderline personality disorder. (22421066)
2012
32
Predicting borderline personality disorder features from personality traits, identity orientation, and attachment styles in Italian nonclinical adults: issues of consistency across age ranges. (22486456)
2012
33
Adult attachment to transitional objects and borderline personality disorder. (22486448)
2012
34
Psychometric evaluation of the Borderline Personality Disorder Severity Index-IV--adolescent version and parent version. (22867512)
2012
35
A growth curve analysis of emotion dysregulation as a mediator for violence in individuals with and without borderline personality disorder. (22686232)
2012
36
The effect of ostracism upon mood in youth with borderline personality disorder. (22023305)
2011
37
The self-image in borderline personality disorder: an in-depth qualitative research study. (21838566)
2011
38
Outcomes in women diagnosed with borderline personality disorder in adolescence. (21804844)
2011
39
Borderline personality disorder subscale (Chinese version) of the structured clinical interview for DSM-IV axis II personality disorders: a validation study in Cantonese-speaking Hong Kong Chinese. (21838207)
2011
40
Dialectical behaviour therapy and an added cognitive behavioural treatment module for eating disorders in women with borderline personality disorder and anorexia nervosa or bulimia nervosa who failed to respond to previous treatments. An open trial with a 15-month follow-up. (20444442)
2010
41
Modulatory role of the brain-derived neurotrophic factor Val66Met polymorphism on the effects of serious life events on impulsive aggression in borderline personality disorder. (19817874)
2010
42
The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in female patients with borderline personality disorder (BPD). (19906087)
2010
43
Borderline Personality Disorder, Bulimia Nervosa, Antisocial Personality Disorder, ADHD, Substance Use: Common Threads, Common Treatment Needs, and the Nature of Impulsivity. (21253443)
2010
44
5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder. (18387137)
2008
45
Borderline personality disorder, antisocial personality disorder and risk-taking among heroin users: findings from the Australian Treatment Outcome Study (ATOS). (15072810)
2004
46
Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse. (12460693)
2002
47
5-HT1A dysfunction in borderline personality disorder. (12171388)
2002
48
m-Chlorophenylpiperazine challenge in borderline personality disorder: relationship of neuroendocrine response, behavioral response, and clinical measures. (8879471)
1996
49
Serotonergic sensitivity in borderline personality disorder: preliminary findings. (8296905)
1994
50
Characterizing somatization, hypochondriasis, and hysteria in the borderline personality disorder. (3716848)
1986

Variations for Borderline Personality Disorder

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Expression for genes affiliated with Borderline Personality Disorder

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Expression patterns in normal tissues for genes affiliated with Borderline Personality Disorder

Search GEO for disease gene expression data for Borderline Personality Disorder.

Pathways for genes affiliated with Borderline Personality Disorder

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Pathways related to Borderline Personality Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Serotonin Transporter Activity37
9.5SLC6A4, MAOA
2
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)37
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA37
tryptophan degradation37
glutaryl-CoA degradation37
serotonin degradation37
NAD de novo biosynthesis37
superpathway of melatonin degradation37
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde37
tryptophan utilization I37
melatonin degradation I37
9.3MAOA, TPH1
3
Show member pathways
9.3MAOA, TPH1
4
Show member pathways
catecholamine biosynthesis37
9.3MAOA, TPH1
58.9TPH1, MAOA, SLC6A4
6
Show member pathways
8.1SLC6A4, MAOA, HTR1B, TPH1
78.1SLC6A4, MAOA, HTR1B, TPH1

Compounds for genes affiliated with Borderline Personality Disorder

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 28IUPHAR
See all sources

Compounds related to Borderline Personality Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1carbon-11449.9MAOA, SLC6A4
2p-chloroamphetamine449.9MAOA, SLC6A4
3phentermine44 1110.9MAOA, SLC6A4
4d amphetamine449.8SLC6A4, MAOA
5minaprine44 1110.8MAOA, SLC6A4
6pseudoephedrine44 24 1111.8MAOA, SLC6A4
7p-chlorophenylalanine449.8TPH1, SLC6A4
8maprotiline44 50 1111.8MAOA, SLC6A4
9mhpg449.8MAOA, SLC6A4
10methylphenidate44 50 1111.7MAOA, SLC6A4
115-hydroxytryptophan449.7TPH1, SLC6A4
12mianserin44 28 1111.6SLC6A4, MAOA
13mcpp449.5SLC6A4, HTR1B
14triptan449.5MAOA, HTR1B
15zolmitriptan44 28 1111.5MAOA, HTR1B
16rizatriptan44 28 1111.5HTR1B, MAOA
17naratriptan44 28 1111.5HTR1B, MAOA
18pindolol44 28 1111.5HTR1B, SLC6A4
19almotriptan44 1110.4HTR1B, MAOA
20carbon449.4TTF2, MAOA, SLC6A4
211 methyl 4 phenylpyridinium449.4SLC6A4, MAOA
22nefazodone44 50 1111.4SLC6A4, HTR1B
23methysergide44 28 1111.4HTR1B, MAOA
24mdma449.3TPH1, MAOA, SLC6A4
25homovanillic acid44 2410.3TPH1, MAOA, SLC6A4
26tryptamine44 28 2411.3MAOA, HTR1B
275-hydroxyindoleacetic acid44 2410.3TPH1, MAOA, SLC6A4
28fluvoxamine44 50 1111.3TPH1, MAOA, SLC6A4
29methamphetamine44 50 1111.3SLC6A4, MAOA, TPH1
30amphetamine44 50 1111.3SLC6A4, MAOA, TPH1
31citalopram44 50 24 1112.3SLC6A4, MAOA, TPH1
32sertraline44 28 50 24 1113.2SLC6A4, MAOA
33ketanserin44 2810.2SLC6A4, HTR1B
34choline44 24 1111.2SLC6A4, MAOA, TPH1
35Serotonin249.1SLC6A4, MAOA, HTR1B
36clomipramine44 50 1111.1SLC6A4, MAOA, HTR1B
37gaba449.0TPH1, MAOA, SLC6A4
38fenfluramine44 28 1111.0TPH1, HTR1B, SLC6A4
39lithium44 50 24 1112.0SLC6A4, HTR1B, TPH1
40levodopa44 119.9MAOA, HTR1B, TPH1
41nicotine44 28 50 1111.9TTF2, TPH1, MAOA, SLC6A4
42maoa448.5SLC6A4, MAOA, HTR1B, TPH1
43paroxetine44 50 28 1111.5TPH1, HTR1B, MAOA, SLC6A4
44fluoxetine44 50 28 1111.5TPH1, HTR1B, MAOA, SLC6A4
45amine448.5SLC6A4, MAOA, HTR1B, TPH1
465-hydroxytryptamine448.5SLC6A4, MAOA, HTR1B, TPH1
47estrogen448.5TTF2, TPH1, MAOA, SLC6A4
48dopamine44 28 24 1111.4TPH1, HTR1B, MAOA, SLC6A4
49cysteine448.4AVPR1A, TTF2, TPH1, MAOA, SLC6A4
50oxygen44 249.2MAOA, HTR1B, TPH1, TTF2

GO Terms for genes affiliated with Borderline Personality Disorder

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Cellular components related to Borderline Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:0430059.4SLC6A4, TPH1

Biological processes related to Borderline Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sperm ejaculationGO:0427139.6SLC6A4, AVPR1A
2circadian rhythmGO:0076239.4SLC6A4, TPH1
3social behaviorGO:0351769.2SLC6A4, AVPR1A
4vasoconstrictionGO:0423109.1HTR1B, SLC6A4
5bone remodelingGO:0468499.0HTR1B, TPH1

Products for genes affiliated with Borderline Personality Disorder

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Sources for Borderline Personality Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet