MCID: BRD004
MIFTS: 39

Borderline Personality Disorder malady

Summaries for Borderline Personality Disorder

About this section


Disease Ontology:9 A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods.

MalaCards based summary: Borderline Personality Disorder is related to personality disorder and substance abuse. An important gene associated with Borderline Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Monoamine Transport and tryptophan utilization II. The compounds carbon-11 and p-chloroamphetamine have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and bone, and related mouse phenotypes are muscle and cardiovascular system.

Wikipedia:63 Borderline personality disorder (BPD) (called emotionally unstable personality disorder, emotional... more...

Aliases & Classifications for Borderline Personality Disorder

About this section

Borderline Personality Disorder, Aliases & Descriptions:

Name: Borderline Personality Disorder 9 11 43 60


External Ids:

Disease Ontology9 DOID:10930
MeSH33 D001883
SNOMED-CT55 20010003, 192488005
ICD9CM27 301.83

Related Diseases for Borderline Personality Disorder

About this section

Diseases related to Borderline Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder31.4MAOA, SLC6A4, HTR1B, TPH1, TTF2
2substance abuse31.1SLC6A4
3substance dependence30.9TPH1, SLC6A4
4melancholia30.8MAOA
5drug dependence30.7SLC6A4, MAOA
6bulimia nervosa30.7HTR1B, MAOA, SLC6A4
7bipolar disorder30.6TPH1, AVPR1A, MAOA, SLC6A4
8intermittent explosive disorder30.6HTR1B
9attention deficit-hyperactivity disorder30.5HTR1B, SLC6A4, MAOA
10anxiety disorder30.5TPH1, MAOA, SLC6A4
11conduct disorder30.5MAOA, SLC6A4, TTF2
12social phobia30.5SLC6A4, MAOA
13anorexia nervosa30.3SLC6A4, MAOA, TPH1
14generalized anxiety disorder30.1TPH1, SLC6A4, MAOA
15antisocial personality disorder30.1TTF2, MAOA, SLC6A4, HTR1B
16mood disorder30.0TPH1, MAOA, SLC6A4, HTR1B
17alcohol dependence30.0HTR1B, MAOA, SLC6A4
18panic disorder29.9TTF2, TPH1, SLC6A4, MAOA
19schizophrenia29.7HTR1B, TTF2, MAOA, TPH1, SLC6A4
20somatoform disorder10.5
21multiple personality disorder10.5
22heroin dependence10.5
23post-traumatic stress disorder10.5
24eating disorder10.5
25alexithymia10.4
26premature ejaculation10.4SLC6A4
27serotonin syndrome10.3MAOA
28narcissistic personality disorder10.3
29obsessive-compulsive personality disorder10.3
30schizotypal personality disorder10.3
31cerebritis10.3
32dissociative disorder10.3
33blindness10.3
34endogenous depression10.2SLC6A4, MAOA
35schizencephaly10.2
36obesity10.2
37polycystic ovary syndrome10.2
38cannabis dependence10.2
39avoidant personality disorder10.2
40oppositional defiant disorder10.2
41neuronitis10.2
42cocaine dependence10.2
43prolactinoma10.2
44schizophreniform disorder10.2
45hypochondriasis10.2
46asperger syndrome10.2
47dissociative amnesia10.2
48dysthymic disorder10.2
49somatization disorder10.2
50bipolar i disorder10.2

Graphical network of the top 20 diseases related to Borderline Personality Disorder:



Diseases related to borderline personality disorder

Symptoms for Borderline Personality Disorder

About this section

Drugs & Therapeutics for Borderline Personality Disorder

About this section

Drug clinical trials:

Search ClinicalTrials for Borderline Personality Disorder

Search NIH Clinical Center for Borderline Personality Disorder

Genetic Tests for Borderline Personality Disorder

About this section

Anatomical Context for Borderline Personality Disorder

About this section

MalaCards organs/tissues related to Borderline Personality Disorder:

31
Brain, Amygdala, Bone, Testes, Cortex, Pituitary, Thyroid, Ovary, Prefrontal cortex

Animal Models for Borderline Personality Disorder or affiliated genes

About this section

MGI Mouse Phenotypes related to Borderline Personality Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.1SLC6A4, HTR1B, TPH1, AVPR1A
2MP:00053857.4SLC6A4, MAOA, HTR1B, TPH1, AVPR1A
3MP:00053867.2AVPR1A, TPH1, HTR1B, MAOA, SLC6A4

Publications for Borderline Personality Disorder

About this section

Articles related to Borderline Personality Disorder:

(show top 50)    (show all 602)
idTitleAuthorsYear
1
Experiences of family carers of people diagnosed with borderline personality disorder. (25857849)
2015
2
Incision and stress regulation in borderline personality disorder: neurobiological mechanisms of self-injurious behaviour. (25906795)
2015
3
Safety and drinking outcomes among patients with comorbid alcohol dependence and borderline personality disorder treated with high-dose baclofen: a comparative cohort study. (25356633)
2014
4
Sexual Feelings Toward the Therapist Among Patients with Borderline Personality Disorder: A Case of Erotomanic Delusional Disorder. (25391585)
2014
5
Day hospital Mentalization-based treatment versus intensive outpatient Mentalization-based treatment for patients with severe borderline personality disorder: protocol of a multicentre randomized clinical trial. (25403144)
2014
6
Emotional cascades as prospective predictors of dysregulated behaviors in borderline personality disorder. (23046043)
2013
7
Distinguishing bipolar II depression from major depressive disorder with comorbid borderline personality disorder: demographic, clinical, and family history differences. (24107761)
2013
8
Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder. (22404662)
2013
9
A Further Validation of the Minnesota Borderline Personality Disorder Scale. (24364505)
2013
10
Getting the word out about treating borderline personality disorder: an online information resource. (23334680)
2013
11
Resident didactic education in borderline personality disorder: is it sufficient? (23820919)
2013
12
Trait anxiety modulates fronto-limbic processing of emotional interference in borderline personality disorder. (23459637)
2013
13
Psychological pathways from childhood sexual and physical abuse to HIV/sexually transmitted infection outcomes among homeless women: the role of posttraumatic stress disorder and borderline personality disorder symptoms. (23180873)
2013
14
Re-offending in forensic patients released from secure care: the role of antisocial/borderline personality disorder co-morbidity, substance dependence and severe childhood conduct disorder. (23371302)
2013
15
Symptoms of borderline personality disorder predict interpersonal (but not independent) stressful life events in a community sample of older adults. (23713502)
2013
16
"It's us that have to deal with it seven days a week": carers and borderline personality disorder. (23054157)
2013
17
Efficacy of omega-3 fatty acids in the treatment of borderline personality disorder: A study of the association with valproic acid. (24196948)
2013
18
Temperamental patterns in female adolescents with borderline personality disorder. (23364119)
2013
19
Personality disorders as maladaptive, extreme variants of normal personality: borderline personality disorder and neuroticism in a substance using sample. (24044664)
2013
20
Borderline personality disorder and emotional intelligence. (23364117)
2013
21
Oxytocin influences avoidant reactions to social threat in adults with borderline personality disorder. (23950057)
2013
22
Alexithymia as a mediator between attachment and the development of borderline personality disorder in adolescence. (23013337)
2012
23
Management of borderline personality disorder. (23027916)
2012
24
Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients. (22633012)
2012
25
Borderline Personality Disorder (BPD) diagnosis with the self-report Personality Diagnostic Questionnairea894+(PDQ-4+): confirmation of the 3-factor structure. (22508070)
2012
26
Identity-related autobiographical memories and cultural life scripts in patients with Borderline Personality Disorder. (22356875)
2012
27
An Empirical Examination of Gunderson's Proposed Revision of the Diagnostic Algorithm for Borderline Personality Disorder. (22984857)
2012
28
Affective startle modulation in incarcerated women with borderline personality disorder features. (22452769)
2012
29
Patient factors predicting early dropout from psychiatric outpatient care for borderline personality disorder. (22503328)
2012
30
Stress Regulation and Incision in Borderline Personality Disorder-A Pilot Study Modeling Cutting Behavior. (22616773)
2012
31
Risky decision-making in borderline personality disorder. (22421066)
2012
32
Predicting borderline personality disorder features from personality traits, identity orientation, and attachment styles in Italian nonclinical adults: issues of consistency across age ranges. (22486456)
2012
33
Adult attachment to transitional objects and borderline personality disorder. (22486448)
2012
34
Psychometric evaluation of the Borderline Personality Disorder Severity Index-IV--adolescent version and parent version. (22867512)
2012
35
A growth curve analysis of emotion dysregulation as a mediator for violence in individuals with and without borderline personality disorder. (22686232)
2012
36
The effect of ostracism upon mood in youth with borderline personality disorder. (22023305)
2011
37
The self-image in borderline personality disorder: an in-depth qualitative research study. (21838566)
2011
38
Outcomes in women diagnosed with borderline personality disorder in adolescence. (21804844)
2011
39
Borderline personality disorder subscale (Chinese version) of the structured clinical interview for DSM-IV axis II personality disorders: a validation study in Cantonese-speaking Hong Kong Chinese. (21838207)
2011
40
Dialectical behaviour therapy and an added cognitive behavioural treatment module for eating disorders in women with borderline personality disorder and anorexia nervosa or bulimia nervosa who failed to respond to previous treatments. An open trial with a 15-month follow-up. (20444442)
2010
41
Modulatory role of the brain-derived neurotrophic factor Val66Met polymorphism on the effects of serious life events on impulsive aggression in borderline personality disorder. (19817874)
2010
42
The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in female patients with borderline personality disorder (BPD). (19906087)
2010
43
Borderline Personality Disorder, Bulimia Nervosa, Antisocial Personality Disorder, ADHD, Substance Use: Common Threads, Common Treatment Needs, and the Nature of Impulsivity. (21253443)
2010
44
5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder. (18387137)
2008
45
Borderline personality disorder, antisocial personality disorder and risk-taking among heroin users: findings from the Australian Treatment Outcome Study (ATOS). (15072810)
2004
46
Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse. (12460693)
2002
47
5-HT1A dysfunction in borderline personality disorder. (12171388)
2002
48
m-Chlorophenylpiperazine challenge in borderline personality disorder: relationship of neuroendocrine response, behavioral response, and clinical measures. (8879471)
1996
49
Serotonergic sensitivity in borderline personality disorder: preliminary findings. (8296905)
1994
50
Characterizing somatization, hypochondriasis, and hysteria in the borderline personality disorder. (3716848)
1986

Variations for Borderline Personality Disorder

About this section

Expression for genes affiliated with Borderline Personality Disorder

About this section
Search GEO for disease gene expression data for Borderline Personality Disorder.

Pathways for genes affiliated with Borderline Personality Disorder

About this section

Pathways related to Borderline Personality Disorder according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Serotonin Transporter Activity36
9.5MAOA, SLC6A4
2
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)36
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA36
tryptophan degradation36
glutaryl-CoA degradation36
serotonin degradation36
NAD de novo biosynthesis36
superpathway of melatonin degradation36
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde36
tryptophan utilization I36
melatonin degradation I36
9.3TPH1, MAOA
3
Show member pathways
9.3TPH1, MAOA
4
Show member pathways
catecholamine biosynthesis36
9.3TPH1, MAOA
58.9SLC6A4, MAOA, TPH1
6
Show member pathways
8.1TPH1, HTR1B, MAOA, SLC6A4
78.1SLC6A4, MAOA, HTR1B, TPH1

Compounds for genes affiliated with Borderline Personality Disorder

About this section
Sources:
43Novoseek, 12DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
See all sources

Compounds related to Borderline Personality Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1carbon-11439.9MAOA, SLC6A4
2p-chloroamphetamine439.9MAOA, SLC6A4
3phentermine43 1210.9SLC6A4, MAOA
4d amphetamine439.8SLC6A4, MAOA
5pseudoephedrine43 24 1211.8SLC6A4, MAOA
6minaprine43 1210.8MAOA, SLC6A4
7p-chlorophenylalanine439.8TPH1, SLC6A4
8maprotiline43 49 1211.8MAOA, SLC6A4
9mhpg439.8MAOA, SLC6A4
10methylphenidate43 49 1211.7SLC6A4, MAOA
115-hydroxytryptophan439.7SLC6A4, TPH1
12mianserin43 28 1211.6MAOA, SLC6A4
13mcpp439.5HTR1B, SLC6A4
14triptan439.5HTR1B, MAOA
15zolmitriptan43 28 1211.5HTR1B, MAOA
16naratriptan43 28 1211.5MAOA, HTR1B
17pindolol43 28 1211.5HTR1B, SLC6A4
18sertraline43 28 49 24 1213.5SLC6A4, MAOA
19rizatriptan43 28 1211.5MAOA, HTR1B
20almotriptan43 1210.4HTR1B, MAOA
21carbon439.4TTF2, SLC6A4, MAOA
221 methyl 4 phenylpyridinium439.4MAOA, SLC6A4
23nefazodone43 49 1211.4SLC6A4, HTR1B
24methysergide43 28 1211.4MAOA, HTR1B
25tryptamine43 28 2411.3HTR1B, MAOA
26mdma439.3SLC6A4, MAOA, TPH1
27homovanillic acid43 2410.3MAOA, TPH1, SLC6A4
285-hydroxyindoleacetic acid43 2410.3MAOA, SLC6A4, TPH1
29fluvoxamine43 49 1211.3SLC6A4, MAOA, TPH1
30methamphetamine43 49 1211.3TPH1, MAOA, SLC6A4
31amphetamine43 49 1211.3MAOA, SLC6A4, TPH1
32citalopram43 49 24 1212.3SLC6A4, MAOA, TPH1
33choline43 24 1211.2SLC6A4, MAOA, TPH1
34Serotonin249.1HTR1B, MAOA, SLC6A4
35clomipramine43 49 1211.1SLC6A4, MAOA, HTR1B
36gaba439.0TPH1, SLC6A4, MAOA
37fenfluramine43 28 1211.0SLC6A4, HTR1B, TPH1
38lithium43 49 24 1212.0TPH1, HTR1B, SLC6A4
39ketanserin43 289.9SLC6A4, HTR1B
40levodopa43 129.9HTR1B, TPH1, MAOA
41nicotine43 28 49 1211.9MAOA, TPH1, SLC6A4, TTF2
42maoa438.5HTR1B, TPH1, SLC6A4, MAOA
43paroxetine43 49 28 1211.5SLC6A4, TPH1, MAOA, HTR1B
44fluoxetine43 49 28 1211.5TPH1, SLC6A4, MAOA, HTR1B
45amine438.5HTR1B, TPH1, MAOA, SLC6A4
465-hydroxytryptamine438.5SLC6A4, MAOA, HTR1B, TPH1
47estrogen438.5SLC6A4, MAOA, TPH1, TTF2
48dopamine43 28 24 1211.4HTR1B, TPH1, MAOA, SLC6A4
49cysteine438.4TPH1, TTF2, AVPR1A, MAOA, SLC6A4
50oxygen43 249.2TPH1, MAOA, HTR1B, TTF2

GO Terms for genes affiliated with Borderline Personality Disorder

About this section

Cellular components related to Borderline Personality Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:00430059.4SLC6A4, TPH1

Biological processes related to Borderline Personality Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sperm ejaculationGO:00427139.6AVPR1A, SLC6A4
2circadian rhythmGO:00076239.4TPH1, SLC6A4
3social behaviorGO:00351769.2AVPR1A, SLC6A4
4vasoconstrictionGO:00423109.1HTR1B, SLC6A4
5bone remodelingGO:00468499.0TPH1, HTR1B

Products for genes affiliated with Borderline Personality Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Borderline Personality Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet