MCID: BRD004
MIFTS: 47

Borderline Personality Disorder malady

Mental diseases category

Summaries for Borderline Personality Disorder

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods.

MalaCards: Borderline Personality Disorder is related to personality disorder and bipolar disorder. An important gene associated with Borderline Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Monoamine Transport and tryptophan utilization II. The compounds carbon-11 and p-chloroamphetamine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and amygdala, and related mouse phenotypes are muscle and cardiovascular system.

Wikipedia:66 Borderline personality disorder (BPD) (called emotionally unstable personality disorder, emotional... more...

Aliases & Classifications for Borderline Personality Disorder

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

borderline personality disorder 9 11 46 63


External Ids:

Disease Ontology9 DOID:10930
MeSH36 D001883
SNOMED-CT59 20010003, 192488005
ICD9CM28 301.83

Related Diseases for Borderline Personality Disorder

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Borderline Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder32.1MAOA, SLC6A4, HTR1B, TPH1, TTF2
2bipolar disorder30.9MAOA, TPH1, SLC6A4
3substance dependence30.8TPH1, SLC6A4
4bulimia nervosa30.8HTR1B, MAOA, SLC6A4
5attention deficit hyperactivity disorder30.7HTR1B, SLC6A4, MAOA
6substance abuse30.6SLC6A4
7conduct disorder30.6MAOA, SLC6A4, TTF2
8drug dependence30.5SLC6A4, MAOA
9antisocial personality disorder30.5TTF2, MAOA, SLC6A4, HTR1B
10mood disorder30.4TPH1, MAOA, SLC6A4, HTR1B
11anxiety disorder30.4TPH1, MAOA, SLC6A4
12anorexia nervosa30.4SLC6A4, MAOA, TPH1
13melancholia30.3MAOA
14intermittent explosive disorder30.3HTR1B
15social phobia30.3SLC6A4, MAOA
16schizophrenia30.2HTR1B, TTF2, MAOA, TPH1, SLC6A4
17panic disorder30.1TTF2, TPH1, SLC6A4, MAOA
18major depressive disorder10.6
19somatoform disorder10.5
20multiple personality disorder10.4
21heroin dependence10.4
22post-traumatic stress disorder10.4
23eating disorder10.4
24alexithymia10.4
25narcissistic personality disorder10.3
26schizotypal personality disorder10.3
27cerebritis10.3
28blindness10.3
29cannabis dependence10.1
30avoidant personality disorder10.1
31obsessive-compulsive personality disorder10.1
32oppositional defiant disorder10.1
33neuronitis10.1
34polycystic ovary syndrome10.1
35cocaine dependence10.1
36prolactinoma10.1
37schizophreniform disorder10.1
38hypochondriasis10.1
39asperger syndrome10.1
40dysthymic disorder10.1
41somatization disorder10.1
42bipolar i disorder10.1
43dissociative disorder10.1
44impulse control disorder10.1
45obesity10.1
46opiate dependence10.1
47schizencephaly10.1
48chronic pain10.1
49premature ejaculation10.1SLC6A4
50serotonin syndrome10.1MAOA

Graphical network of the top 20 diseases related to Borderline Personality Disorder:



Diseases related to borderline personality disorder

Symptoms for Borderline Personality Disorder

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Drugs & Therapeutics for Borderline Personality Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Borderline Personality Disorder

Drug clinical trials:

Search ClinicalTrials for Borderline Personality Disorder

Search NIH Clinical Center for Borderline Personality Disorder

Search CenterWatch for Borderline Personality Disorder

Genetic Tests for Borderline Personality Disorder

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Anatomical Context for Borderline Personality Disorder

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Sources:
34MalaCards
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MalaCards organs/tissues related to Borderline Personality Disorder:

34
Brain, Bone, Amygdala, Testes, Pituitary, Cortex, Ovary, Prefrontal cortex

Animal Models for Borderline Personality Disorder or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Borderline Personality Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.1SLC6A4, HTR1B, TPH1, AVPR1A
2MP:00053857.4SLC6A4, MAOA, HTR1B, TPH1, AVPR1A
3MP:00053867.2AVPR1A, TPH1, HTR1B, MAOA, SLC6A4

Publications for Borderline Personality Disorder

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Sources:
53PubMed
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Articles related to Borderline Personality Disorder:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Emotional cascades as prospective predictors of dysregulated behaviors in borderline personality disorder. (23046043)
2013
2
Distinguishing bipolar II depression from major depressive disorder with comorbid borderline personality disorder: demographic, clinical, and family history differences. (24107761)
2013
3
Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder. (22404662)
2013
4
A Further Validation of the Minnesota Borderline Personality Disorder Scale. (24364505)
2013
5
Getting the word out about treating borderline personality disorder: an online information resource. (23334680)
2013
6
Resident didactic education in borderline personality disorder: is it sufficient? (23820919)
2013
7
Trait anxiety modulates fronto-limbic processing of emotional interference in borderline personality disorder. (23459637)
2013
8
Psychological pathways from childhood sexual and physical abuse to HIV/sexually transmitted infection outcomes among homeless women: the role of posttraumatic stress disorder and borderline personality disorder symptoms. (23180873)
2013
9
Re-offending in forensic patients released from secure care: the role of antisocial/borderline personality disorder co-morbidity, substance dependence and severe childhood conduct disorder. (23371302)
2013
10
Symptoms of borderline personality disorder predict interpersonal (but not independent) stressful life events in a community sample of older adults. (23713502)
2013
11
"It's us that have to deal with it seven days a week": carers and borderline personality disorder. (23054157)
2013
12
Efficacy of omega-3 fatty acids in the treatment of borderline personality disorder: A study of the association with valproic acid. (24196948)
2013
13
Temperamental patterns in female adolescents with borderline personality disorder. (23364119)
2013
14
Personality disorders as maladaptive, extreme variants of normal personality: borderline personality disorder and neuroticism in a substance using sample. (24044664)
2013
15
Borderline personality disorder and emotional intelligence. (23364117)
2013
16
Oxytocin influences avoidant reactions to social threat in adults with borderline personality disorder. (23950057)
2013
17
Multimodal examination of emotion regulation difficulties as a function of co-occurring avoidant personality disorder among women with borderline personality disorder. (24378158)
2013
18
Alexithymia as a mediator between attachment and the development of borderline personality disorder in adolescence. (23013337)
2012
19
Gender Differences in a Clinical Sample of Patients with Borderline Personality Disorder. (22494170)
2012
20
Management of borderline personality disorder. (23027916)
2012
21
Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients. (22633012)
2012
22
Borderline Personality Disorder (BPD) diagnosis with the self-report Personality Diagnostic Questionnairea894+(PDQ-4+): confirmation of the 3-factor structure. (22508070)
2012
23
Identity-related autobiographical memories and cultural life scripts in patients with Borderline Personality Disorder. (22356875)
2012
24
An Empirical Examination of Gunderson's Proposed Revision of the Diagnostic Algorithm for Borderline Personality Disorder. (22984857)
2012
25
Affective startle modulation in incarcerated women with borderline personality disorder features. (22452769)
2012
26
Patient factors predicting early dropout from psychiatric outpatient care for borderline personality disorder. (22503328)
2012
27
Stress Regulation and Incision in Borderline Personality Disorder-A Pilot Study Modeling Cutting Behavior. (22616773)
2012
28
Risky decision-making in borderline personality disorder. (22421066)
2012
29
Predicting borderline personality disorder features from personality traits, identity orientation, and attachment styles in Italian nonclinical adults: issues of consistency across age ranges. (22486456)
2012
30
Adult attachment to transitional objects and borderline personality disorder. (22486448)
2012
31
Psychometric evaluation of the Borderline Personality Disorder Severity Index-IV--adolescent version and parent version. (22867512)
2012
32
A growth curve analysis of emotion dysregulation as a mediator for violence in individuals with and without borderline personality disorder. (22686232)
2012
33
Neural responses to emotional stimuli in comorbid borderline personality disorder and bipolar depression. (22871390)
2012
34
Facets of psychopathy in relation to potentially traumatic events and posttraumatic stress disorder among female prisoners: the mediating role of borderline personality disorder traits. (22452777)
2012
35
The effect of ostracism upon mood in youth with borderline personality disorder. (22023305)
2011
36
The self-image in borderline personality disorder: an in-depth qualitative research study. (21838566)
2011
37
Outcomes in women diagnosed with borderline personality disorder in adolescence. (21804844)
2011
38
Borderline personality disorder subscale (Chinese version) of the structured clinical interview for DSM-IV axis II personality disorders: a validation study in Cantonese-speaking Hong Kong Chinese. (21838207)
2011
39
Family study of borderline personality disorder and its sectors of psychopathology. (21727257)
2011
40
Dialectical behaviour therapy and an added cognitive behavioural treatment module for eating disorders in women with borderline personality disorder and anorexia nervosa or bulimia nervosa who failed to respond to previous treatments. An open trial with a 15-month follow-up. (20444442)
2010
41
Modulatory role of the brain-derived neurotrophic factor Val66Met polymorphism on the effects of serious life events on impulsive aggression in borderline personality disorder. (19817874)
2010
42
The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in female patients with borderline personality disorder (BPD). (19906087)
2010
43
Borderline Personality Disorder, Bulimia Nervosa, Antisocial Personality Disorder, ADHD, Substance Use: Common Threads, Common Treatment Needs, and the Nature of Impulsivity. (21253443)
2010
44
5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder. (18387137)
2008
45
Borderline personality disorder, antisocial personality disorder and risk-taking among heroin users: findings from the Australian Treatment Outcome Study (ATOS). (15072810)
2004
46
Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse. (12460693)
2002
47
5-HT1A dysfunction in borderline personality disorder. (12171388)
2002
48
m-Chlorophenylpiperazine challenge in borderline personality disorder: relationship of neuroendocrine response, behavioral response, and clinical measures. (8879471)
1996
49
Serotonergic sensitivity in borderline personality disorder: preliminary findings. (8296905)
1994
50
Characterizing somatization, hypochondriasis, and hysteria in the borderline personality disorder. (3716848)
1986

Variations for Borderline Personality Disorder

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Expression for genes affiliated with Borderline Personality Disorder

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Borderline Personality Disorder

Search GEO for disease gene expression data for Borderline Personality Disorder.

Pathways for genes affiliated with Borderline Personality Disorder

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 52PharmGKB
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Pathways related to Borderline Personality Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Serotonin Transporter Activity39
9.5MAOA, SLC6A4
2
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)39
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA39
tryptophan degradation39
glutaryl-CoA degradation39
serotonin degradation39
NAD de novo biosynthesis39
superpathway of melatonin degradation39
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde39
tryptophan utilization I39
melatonin degradation I39
9.3TPH1, MAOA
3
Show member pathways
9.3TPH1, MAOA
4
Show member pathways
catecholamine biosynthesis39
9.3TPH1, MAOA
58.9SLC6A4, MAOA, TPH1
6
Show member pathways
8.1TPH1, HTR1B, MAOA, SLC6A4
78.1SLC6A4, MAOA, HTR1B, TPH1

Compounds for genes affiliated with Borderline Personality Disorder

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 30IUPHAR
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Compounds related to Borderline Personality Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1carbon-11469.9MAOA, SLC6A4
2p-chloroamphetamine469.9MAOA, SLC6A4
3phentermine46 1210.9SLC6A4, MAOA
4d amphetamine469.8SLC6A4, MAOA
5pseudoephedrine46 25 1211.8SLC6A4, MAOA
6minaprine46 1210.8MAOA, SLC6A4
7p-chlorophenylalanine469.8TPH1, SLC6A4
8maprotiline46 52 1211.8MAOA, SLC6A4
9mhpg469.8MAOA, SLC6A4
10methylphenidate46 52 1211.7SLC6A4, MAOA
115-hydroxytryptophan469.7SLC6A4, TPH1
12mianserin46 30 1211.6MAOA, SLC6A4
13mcpp469.5HTR1B, SLC6A4
14triptan469.5HTR1B, MAOA
15zolmitriptan46 30 1211.5HTR1B, MAOA
16naratriptan46 30 1211.5MAOA, HTR1B
17pindolol46 30 1211.5HTR1B, SLC6A4
18sertraline46 30 52 25 1213.5SLC6A4, MAOA
19rizatriptan46 30 1211.5MAOA, HTR1B
20almotriptan46 1210.4HTR1B, MAOA
21carbon469.4TTF2, SLC6A4, MAOA
221 methyl 4 phenylpyridinium469.4MAOA, SLC6A4
23nefazodone46 52 1211.4SLC6A4, HTR1B
24methysergide46 30 1211.4MAOA, HTR1B
25tryptamine46 30 2511.3HTR1B, MAOA
26mdma469.3SLC6A4, MAOA, TPH1
27homovanillic acid46 2510.3MAOA, TPH1, SLC6A4
285-hydroxyindoleacetic acid46 2510.3MAOA, SLC6A4, TPH1
29fluvoxamine46 52 1211.3SLC6A4, MAOA, TPH1
30methamphetamine46 52 1211.3TPH1, MAOA, SLC6A4
31amphetamine46 52 1211.3MAOA, SLC6A4, TPH1
32citalopram46 52 25 1212.3SLC6A4, MAOA, TPH1
33choline46 25 1211.2SLC6A4, MAOA, TPH1
34Serotonin259.1HTR1B, MAOA, SLC6A4
35clomipramine46 52 1211.1SLC6A4, MAOA, HTR1B
36gaba469.0TPH1, SLC6A4, MAOA
37fenfluramine46 30 1211.0SLC6A4, HTR1B, TPH1
38lithium46 52 25 1212.0TPH1, HTR1B, SLC6A4
39ketanserin46 309.9SLC6A4, HTR1B
40levodopa46 129.9HTR1B, TPH1, MAOA
41nicotine46 30 52 1211.9MAOA, TPH1, SLC6A4, TTF2
42maoa468.5HTR1B, TPH1, SLC6A4, MAOA
43paroxetine46 52 30 1211.5SLC6A4, TPH1, MAOA, HTR1B
44fluoxetine46 52 30 1211.5TPH1, SLC6A4, MAOA, HTR1B
45amine468.5HTR1B, TPH1, MAOA, SLC6A4
465-hydroxytryptamine468.5SLC6A4, MAOA, HTR1B, TPH1
47estrogen468.5SLC6A4, MAOA, TPH1, TTF2
48dopamine46 30 25 1211.4HTR1B, TPH1, MAOA, SLC6A4
49cysteine468.4TPH1, TTF2, AVPR1A, MAOA, SLC6A4
50oxygen46 259.2TPH1, MAOA, HTR1B, TTF2

GO Terms for genes affiliated with Borderline Personality Disorder

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Sources:
17Gene Ontology
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Cellular components related to Borderline Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:0430059.4SLC6A4, TPH1

Biological processes related to Borderline Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sperm ejaculationGO:0427139.6SLC6A4, AVPR1A
2circadian rhythmGO:0076239.4SLC6A4, TPH1
3social behaviorGO:0351769.2SLC6A4, AVPR1A
4vasoconstrictionGO:0423109.1HTR1B, SLC6A4
5bone remodelingGO:0468499.0HTR1B, TPH1

Products for genes affiliated with Borderline Personality Disorder

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  • Antibodies
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Sources for Borderline Personality Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet