MCID: BRD004
MIFTS: 52

Borderline Personality Disorder malady

Summaries for Borderline Personality Disorder

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods.

MalaCards: Borderline Personality Disorder is related to bipolar disorder and bulimia nervosa. An important gene associated with Borderline Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Monoamine GPCRs and Tryptophan metabolism. The compounds m-chlorophenylpiperazine and naratriptan have been mentioned in the context of this disorder. Affiliated tissues include ovary, brain and cortex, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Wikipedia:64 Borderline personality disorder (BPD) (called emotionally unstable personality disorder, emotional... more...

Aliases & Classifications for Borderline Personality Disorder

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM
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Aliases & Descriptions:

borderline personality disorder 8 10 45 61


External Ids:

Disease Ontology8 DOID:10930
MeSH35 D001883
SNOMED-CT57 192488005, 20010003
ICD9CM27 301.83

Related Diseases for Borderline Personality Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Borderline Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder31.2SLC6A4, HTR2A, HTR3A
2bulimia nervosa30.8COMT, BDNF, HTR1B, HTR3A, HTR2A, MAOA
3substance dependence30.8TPH1, SLC6A4, COMT
4antisocial personality disorder30.7HTR1B, HTR2A, MAOA, TTF2, SLC6A4
5attention deficit hyperactivity disorder30.7COMT, BDNF, HTR1B, HTR2A, MAOA, SLC6A4
6anorexia nervosa30.5BDNF, HTR2A
7conduct disorder30.5COMT, MAOA, TTF2, SLC6A4
8anxiety disorder30.5BDNF, HTR3A, CRH, MAOA, SLC6A4, TPH1
9substance abuse30.4SLC6A4, CRH
10obsessive-compulsive personality disorder30.4CLPS, SLC6A4
11schizotypal personality disorder30.4COMT, FLNA
12obsessive-compulsive disorder30.4TPH2, TPH1, SLC6A4, COMT, BDNF, HTR1B
13nicotine dependence30.2SLC6A4
14cocaine dependence30.2SLC6A4
15melancholia30.2CRH, MAOA
16dysthymic disorder30.2HTR2A, MAOA
17panic disorder30.2HTR1A, HTR3A, CRH, SLC6A4
18social phobia30.2COMT, HTR1A, HTR3A, MAOA, SLC6A4
19alcohol dependence30.2MAOA, SLC6A4, CRH, HTR2A, HTR1B
20polycystic ovary syndrome30.2PRL, CRH
21major depressive disorder10.6
22sleep disorder10.6
23pain disorder10.5
24post-traumatic stress disorder10.5
25somatoform disorder10.5
26avoidant personality disorder10.4
27dependent personality disorder10.4
28multiple personality disorder10.4
29alexithymia10.4
30bipolar i disorder10.4
31narcissistic personality disorder10.3
32somatization disorder10.3
33heroin dependence10.3
34prolactinoma10.1
35cannabis dependence10.1
36klinefelter's syndrome10.1
37expressive language disorder10.1
38schizophreniform disorder10.1
39hypochondriasis10.1
40neurotic disorder10.1
41asperger syndrome10.1
42adult syndrome10.1
43intermittent explosive disorder10.1
44rumination disorder10.1
45schizencephaly10.1
46chronic pain10.1
47eating disorder10.0SLC6A4
48restless legs syndrome10.0HTR3A
49dyspepsia10.0HTR3A
50paranoid schizophrenia10.0COMT

Graphical network of the top 20 diseases related to Borderline Personality Disorder:



Diseases related to borderline personality disorder

Clinical Features for Borderline Personality Disorder

Drugs & Therapeutics for Borderline Personality Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Borderline Personality Disorder

Drug clinical trials:

Search ClinicalTrials for Borderline Personality Disorder

Search NIH Clinical Center for Borderline Personality Disorder

Search CenterWatch for Borderline Personality Disorder

Genetic Tests for Borderline Personality Disorder

Anatomical Context for Borderline Personality Disorder

Sources:
33MalaCards
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MalaCards organs/tissues related to Borderline Personality Disorder:

33
Ovary, Brain, Cortex, Prefrontal cortex, Amygdala, Adrenal cortex, Pituitary

Animal Models for Borderline Personality Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Borderline Personality Disorder

Sources:
51PubMed
See all sources

Articles related to Borderline Personality Disorder:

(show top 50)    (show all 585)
idTitleAuthorsYear
1
Re-offending in forensic patients released from secure care: the role of antisocial/borderline personality disorder co-morbidity, substance dependence and severe childhood conduct disorder. (23371302)
2013
2
Personality disorders as maladaptive, extreme variants of normal personality: borderline personality disorder and neuroticism in a substance using sample. (24044664)
2013
3
Multimodal examination of emotion regulation difficulties as a function of co-occurring avoidant personality disorder among women with borderline personality disorder. (24378158)
2013
4
The borderline empathy paradox: evidence and conceptual models for empathic enhancements in borderline personality disorder. (23514182)
2013
5
The effect of anger rumination in the relationship between borderline personality disorder symptoms and precursors. (23586935)
2013
6
Emotion dysregulation as a maintenance factor of borderline personality disorder features. (24342056)
2013
7
Methylation of the glucocorticoid receptor gene promoter in bulimic women: associations with borderline personality disorder, suicidality, and exposure to childhood abuse. (23417893)
2013
8
Tests of a direct effect of childhood abuse on adult borderline personality disorder traits: a longitudinal discordant twin design. (22686871)
2013
9
Outcome of mentalization-based and supportive psychotherapy in patients with borderline personality disorder: a randomized trial. (22897123)
2013
10
Alliance ruptures and resolution during cognitive behaviour therapy with patients with borderline personality disorder. (24200026)
2013
11
The effects of borderline personality disorder and panic disorder on suicide attempts and the associated influence of affective dysregulation in the general population. (23364122)
2013
12
Predictors of psychotherapy alliance in Borderline Personality Disorder. (23721453)
2013
13
Management of end-of-life care and of difficult behaviors associated with borderline personality disorder. (22921178)
2013
14
Cognitive analytic therapy for borderline personality disorder: therapist competence and therapeutic effectiveness in routine practice. (22109975)
2013
15
Self-esteem and other-esteem in college students with borderline and avoidant personality disorder features: An experimental vignette study. (24343980)
2013
16
Borderline personality disorder in adolescence: the case for medium stay inpatient treatment. (23507818)
2013
17
Facial Reactions during Emotion Recognition in Borderline Personality Disorder: A Facial Electromyography Study. (24021701)
2013
18
Reduced plasma oxytocin levels in female patients with borderline personality disorder. (23201337)
2013
19
Relationship between maladaptive cognitions about sleep and recovery in patients with borderline personality disorder. (23972789)
2013
20
Auditory hallucinations: a comparison of beliefs about voices in individuals with schizophrenia and borderline personality disorder. (21976361)
2013
21
Preoccupied attachment and emotional dysregulation: specific aspects of borderline personality disorder or general dimensions of personality pathology? (23586934)
2013
22
Adult antisocial syndrome co-morbid with borderline personality disorder is associated with severe conduct disorder, substance dependence and violent antisociality. (24343921)
2013
23
Relationship between sleep disturbance and recovery in patients with borderline personality disorder. (23497827)
2013
24
Treating patients with borderline personality disorder in the medical office. (23939648)
2013
25
Borderline personality disorder, bipolar disorder, depression, attention deficit/hyperactivity disorder, and narcissistic personality disorder: Practical differential diagnosis. (23428169)
2013
26
Review: some evidence of benefit for psychotherapies in borderline personality disorder. (23171500)
2013
27
Gender Differences in a Clinical Sample of Patients with Borderline Personality Disorder. (22494170)
2012
28
Risky decision-making in borderline personality disorder. (22421066)
2012
29
Neural responses to emotional stimuli in comorbid borderline personality disorder and bipolar depression. (22871390)
2012
30
Factors predicting the outcome of psychotherapy for borderline personality disorder: a systematic review. (22681913)
2012
31
Three cases of dissociative identity disorder and co-occurring borderline personality disorder treated with dynamic deconstructive psychotherapy. (22876528)
2012
32
Borderline Personality Disorder Features and Mate Retention Tactics. (22494171)
2012
33
Observer-rated Coping Associated with Borderline Personality Disorder: An Exploratory Study. (23281000)
2012
34
Ecological Momentary Assessment in Borderline Personality Disorder: A Review of Recent Findings and Methodological Challenges. (22984853)
2012
35
Are DSM-IV-TR Borderline Personality Disorder, ICD-10 Emotionally Unstable Personality Disorder, and CCMD-III Impulsive Personality Disorder Analogous Diagnostic Categories Across Psychiatric Nomenclatures? (22643091)
2012
36
Clinical psychopharmacology of borderline personality disorder: an update on the available evidence in light of the Diagnostic and Statistical Manual of Mental Disorders - 5. (22037092)
2012
37
Personality disorder categories as combinations of dimensions: translating cooperative behavior in borderline personality disorder into the five-factor framework. (22486457)
2012
38
Activation of the cholinergic anti-inflammatory system in peripheral blood mononuclear cells from patients with borderline personality disorder. (23083519)
2012
39
Empathy and alexithymia in borderline personality disorder: clinical and laboratory measures. (23013336)
2012
40
Treatment for comorbid borderline personality disorder and alcohol use disorders: a review of the evidence and future recommendations. (22686496)
2012
41
A (re)-evaluation of the symptom structure of borderline personality disorder. (21959028)
2011
42
The relationship between borderline personality disorder and number of sexual partners. (22217224)
2011
43
ECT revisited: impact on major depression in borderline personality disorder. (21981774)
2011
44
Treatment terminable and interminable: implications of the mental health act 2007 in England and Wales for the treatment of borderline personality disorder. (21928366)
2011
45
Dialectical behaviour therapy and an added cognitive behavioural treatment module for eating disorders in women with borderline personality disorder and anorexia nervosa or bulimia nervosa who failed to respond to previous treatments. An open trial with a 15-month follow-up. (20444442)
2010
46
5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder. (18387137)
2008
47
Questioning the coherence of histrionic personality disorder: borderline and hysterical personality subtypes in adults and adolescents. (19008729)
2008
48
Predicting borderline and antisocial personality disorder features in nonclinical subjects using measures of impulsivity and aggressiveness. (15006439)
2004
49
Substance abuse patterns and their association with psychopathology and type of hostility in male patients with borderline and antisocial personality disorder. (10428187)
1999
50
Relationship of childhood sexual abuse to borderline personality disorder, posttraumatic stress disorder, and multiple personality disorder. (8301618)
1993

Genetic Variations for Borderline Personality Disorder

Expression for genes affiliated with Borderline Personality Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Borderline Personality Disorder

Search GEO for disease gene expression data for Borderline Personality Disorder.

Pathways for genes affiliated with Borderline Personality Disorder

Sources:
38NCBI BioSystems Database, 50PharmGKB, 30KEGG, 54Reactome, 52QIAGEN
See all sources

Pathways related to Borderline Personality Disorder according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2TPH1, TPH2
2
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10.2TPH2, TPH1
3
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10.2TPH1, TPH2
4
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10.2MAOA, COMT
5
Hide members
10.1TPH2, TPH1, MAOA
6
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10.1TPH2, TPH1, MAOA
7
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9.4BDNF, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
8
Hide members
9.3SLC6A4, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
9
Hide members
9.3HTR1B, HTR1A, HTR2A, HTR1D, CRH, PRL
109.2BDNF, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
11
Hide members
9.2COMT, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
12
Hide members
9.1HTR1B, HTR1A, HTR2A, HTR1D, CRH, PRL

Compounds for genes affiliated with Borderline Personality Disorder

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Borderline Personality Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 287)
idCompoundScoreTop Affiliating Genes
1m-chlorophenylpiperazine4510.0HTR2A, PRL, HTR3A, HTR1A, SLC6A4
2naratriptan45 29 1112.0HTR2A, HTR1A, HTR1B, HTR1D, MAOA
3cyanopindolol45 2910.9HTR2A, HTR1D, HTR1A, HTR3A, HTR1B
4mcpp459.9HTR1A, HTR1B, SLC6A4, HTR3A, HTR2A, PRL
5pindolol45 29 1111.9SLC6A4, PRL, HTR2A, HTR3A, HTR1A, HTR1B
62-methyl-5-ht45 2910.9HTR1A, HTR1B, HTR3A, HTR2A, HTR1D
7mdma459.9PRL, HTR1A, MAOA, SLC6A4, TPH1
8ru 2496929 4510.9HTR1B, HTR1D, HTR2A, HTR3A, HTR1A
95-carboxamidotryptamine459.9HTR1D, HTR3A, HTR1A, HTR1B, HTR2A
10ipsapirone45 2910.9HTR1D, PRL, HTR2A, HTR3A, HTR1B, HTR1A
11methysergide45 29 1111.8HTR1B, MAOA, HTR1D, HTR2A, HTR3A, HTR1A
12mhpg459.8COMT, BDNF, CRH, PRL, SLC6A4, MAOA
13mirtazapine50 45 1111.8PRL, CRH, HTR2A, SLC6A4, HTR3A, TPH2
14zotepine45 2910.8HTR1D, HTR2A, PRL, HTR1B, HTR1A, HTR3A
15fluvoxamine45 50 1111.8HTR1A, HTR3A, HTR2A, MAOA, SLC6A4, TPH1
16ritanserin29 4510.8HTR3A, PRL, HTR1D, HTR2A, HTR1A, HTR1B
17dihydroergotamine29 45 1111.8HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
18metergoline45 2910.8HTR1B, HTR3A, HTR1A, HTR1D, HTR2A, PRL
19sumatriptan45 29 60 50 11 2414.8HTR1A, HTR3A, HTR2A, HTR1D, HTR1B, MAOA
20pergolide29 45 1111.8HTR1A, HTR1B, HTR2A, HTR1D, PRL, COMT
215-hydroxytryptophan459.8HTR1A, HTR3A, HTR2A, CRH, PRL, SLC6A4
22homovanillic acid45 2410.8TPH1, COMT, BDNF, CRH, PRL, MAOA
23venlafaxine50 45 11 2412.8BDNF, HTR1B, HTR1A, HTR3A, HTR2A, SLC6A4
24cabergoline29 45 1111.8HTR1B, PRL, HTR1D, HTR2A, HTR1A, COMT
25clomipramine45 50 1111.7HTR1A, HTR3A, HTR2A, CRH, PRL, MAOA
26aripiprazole29 50 45 11 2413.7HTR1B, HTR3A, HTR2A, HTR1D, PRL, HTR1A
27ketanserin29 4510.7HTR2A, HTR3A, HTR1A, HTR1B, BDNF, HTR1D
28ziprasidone50 29 45 1112.7PRL, HTR1D, HTR3A, HTR1A, HTR1B, HTR2A
29terguride29 4510.7HTR1D, HTR2A, HTR1A, HTR1B, PRL
30pramipexole45 50 29 1112.7PRL, HTR1D, HTR2A, COMT, HTR1A, HTR1B
31apomorphine45 29 1111.7COMT, HTR2A, HTR1B, HTR1D, PRL, HTR1A
32yohimbine45 29 2 1112.7HTR2A, HTR1D, HTR1A, HTR3A, CRH, HTR1B
33citalopram50 45 11 2412.6TPH1, SLC6A4, BDNF, HTR1A, HTR3A, PRL
34quetiapine45 50 29 11 2413.6BDNF, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
35levodopa45 1110.5HTR1B, MAOA, COMT, BDNF, TPH1, PRL
36antidepressants509.5BDNF, HTR2A, TPH1, TPH2, HTR1A
37amine459.5TPH1, SLC6A4, MAOA, HTR1D, HTR3A, HTR1B
38maoa459.5COMT, MAOA, BDNF, HTR1B, HTR1A, HTR2A
39olanzapine50 45 29 11 2413.5COMT, BDNF, HTR1B, HTR1A, HTR3A, HTR2A
40desipramine45 50 1111.5HTR1A, HTR2A, BDNF, CRH, MAOA, SLC6A4
41fenfluramine29 45 1111.5TPH2, TPH1, HTR1B, HTR1A, HTR3A, HTR2A
42risperidone29 45 50 60 11 2414.4SLC6A4, PRL, HTR1D, HTR2A, HTR3A, HTR1A
43clozapine45 29 50 1112.3COMT, BDNF, HTR1B, HTR1A, HTR3A, HTR2A
44paroxetine45 50 29 1112.3PRL, MAOA, SLC6A4, TPH1, HTR2A, COMT
45methiothepin45 2910.3HTR1B, HTR1A, HTR2A, HTR1D, HTR3A
46haloperidol45 29 2 50 1113.2HTR1A, BDNF, HTR3A, HTR1D, PRL, SLC6A4
47fluoxetine50 45 29 1112.1BDNF, HTR1B, HTR1A, HTR3A, HTR2A, CRH
48norepinephrine45 11 2411.0COMT, TPH1, SLC6A4, BDNF, HTR1A, HTR3A
49dopamine45 29 11 2412.0COMT, BDNF, HTR1A, HTR3A, HTR2A, HTR1D
505-hydroxytryptamine458.9HTR1B, HTR1A, HTR3A, HTR2A, HTR1D, CRH

GO Terms for genes affiliated with Borderline Personality Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Borderline Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.0SLC6A4, HTR1B, HTR1A, HTR3A, HTR2A, HTR1D
2plasma membraneGO:0058868.7HTR1B, HTR1A, HTR3A, HTR2A, HTR1D, FLNA

Biological processes related to Borderline Personality Disorder according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase-inhibiting serotonin receptor signaling pathwayGO:00719810.5HTR1B, HTR1A
2serotonin biosynthetic processGO:04242710.5TPH1, TPH2
3aromatic amino acid family metabolic processGO:00907210.5TPH1, TPH2
4regulation of serotonin secretionGO:01406210.4HTR1A, CRH
5dopamine catabolic processGO:04242010.4COMT, MAOA
6regulation of hormone secretionGO:04688310.4HTR1A, HTR2A
7indolalkylamine biosynthetic processGO:04621910.4TPH2, TPH1
8response to immobilization stressGO:03590210.4CRH, TPH1
9sperm ejaculationGO:04271310.4AVPR1A, SLC6A4
10neurotransmitter catabolic processGO:04213510.3MAOA, COMT
11serotonin receptor signaling pathwayGO:00721010.3HTR1A, HTR3A, HTR2A
12negative regulation of synaptic transmission, glutamatergicGO:05196710.2HTR2A, HTR1B
13parturitionGO:00756710.2PRL, CRH
14circadian rhythmGO:00762310.2TPH2, TPH1, SLC6A4, PRL
15vasoconstrictionGO:04231010.2HTR1B, HTR1A, HTR1D, SLC6A4
16neurotransmitter biosynthetic processGO:04213610.2MAOA, COMT
17regulation of behaviorGO:05079510.1HTR1D, HTR2A, HTR1A, HTR1B
18response to estrogen stimulusGO:04362710.1TPH2, CRH, BGLAP
19regulation of dopamine secretionGO:01405910.1HTR2A, HTR1B
20response to ethanolGO:04547110.0PRL, CRH, HTR1B, BGLAP
21female pregnancyGO:0075659.9COMT, CRH, PRL
22bone remodelingGO:0468499.9TPH1, HTR1B
23response to drugGO:0424939.7COMT, BGLAP, HTR2A, CRH, PRL, SLC6A4
24synaptic transmissionGO:0072689.6COMT, HTR1B, HTR3A, HTR2A, HTR1D, CRH

Molecular functions related to Borderline Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tryptophan 5-monooxygenase activityGO:00451010.2TPH2, TPH1
2serotonin receptor activityGO:0049939.5HTR1D, HTR2A, HTR3A, HTR1A, HTR1B
3serotonin bindingGO:0513789.5HTR1B, HTR3A, HTR2A, HTR1D

Products for genes affiliated with Borderline Personality Disorder

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  • Proteins
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Sources for Borderline Personality Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet