Borderline Personality Disorder malady

Disease Ontology: A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods.⁶

MalaCards: Borderline Personality Disorder, also known as borderline personality disease, is related to personality disorder and major depressive disorder. An important gene associated with Borderline Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Tryptophan metabolism and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The compounds yohimbine and mdma have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and pituitary, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Wikipedia: Borderline personality disorder (BPD) (called emotionally unstable personality disorder, borderline type...⁴⁴ more...

Aliases & Descriptions:

borderline personality disorder 6 32 43 borderline personality disease 8

Diseases related to borderline personality disorder by text searches and GeneDecks gene sharing:

(show top 50)    (show all 232)

id	Related Disease	Score	Top Affiliating Genes
1	personality disorder	34.1	MAOA, HTR1B, TPH1, TPH2, TTF2, SLC6A3
2	major depressive disorder	22.9	BGLAP, BDNF, IL6, MAOA, HTR1A, HTR1B
3	generalized anxiety disorder	13.5	HTR1A, SLC6A4
4	conduct disorder	13.4	MAOA, HTR1B, SLC6A4
5	novelty seeking personality	13.4	MAOA, COMT
6	dysthymic disorder	13.4	MAOA, HTR2A
7	anorexia nervosa	13.3	BDNF, HTR2A
8	endogenous depression	13.3	MAOA, CRH, SLC6A4
9	cognitive disease	13.2	MAOA, HTR1A, COMT
10	fragile x syndrome	13.2	BDNF, MAOA, SLC6A4
11	bipolar disorder	13.2	HTR1A, SLC6A4
12	anxiety-related personality traits	13.2	BDNF, COMT, SLC6A4
13	developmental disabilities	13.2	BDNF, MAOA, HTR1A
14	post-traumatic stress disorder	13.1	BDNF, MAOA, CRH
15	somatoform disorder	13.1	COMT, TTF2
16	childhood-onset schizophrenia	13.0	TPH1, PRL
17	monoclonal gammopathy of uncertain significance	13.0	BGLAP, IL6
18	schizophrenia	13.0	HTR2A, COMT
19	burning mouth syndrome	13.0	SCN9A, IL6, SLC6A4
20	antisocial personality disorder	13.0	MAOA, HTR1B, HTR2A, SLC6A4
21	ocular hypotension	13.0	HTR1A, HTR2A
22	bulimia nervosa	12.9	HTR3A, COMT, SLC6A4
23	hypothalamic disease	12.9	CRH, PRL
24	pituitary-dependent cushing's disease	12.9	CRH, PRL
25	cyclic vomiting syndrome	12.9	IL6, HTR3A
26	heart valve disease	12.9	HTR2A, HTR3A
27	isolated acth deficiency	12.9	CRH, PRL
28	chronic pain	12.9	IL6, COMT, TTF2
29	major affective disorder	12.9	HTR2A, HTR3A, SLC6A4
30	nelson syndrome	12.9	CRH, PRL
31	autonomic dysfunction	12.9	BDNF, SCN9A, IL6
32	sheehan syndrome	12.8	CRH, PRL
33	petrositis	12.8	CRH, PRL
34	relapsing-remitting multiple sclerosis	12.8	BDNF, IL6, MAOA
35	neuroleptic malignant syndrome	12.8	HTR1A, HTR2A, HTR3A
36	pulmonary hypertension	12.8	HTR1B, HTR3A, TPH1, SLC6A4
37	neurogenic diabetes insipidus	12.8	CRH, PRL
38	febrile seizures	12.8	BDNF, SCN9A, IL6
39	pathological gambling	12.8	MAOA, SLC6A3, SLC6A4
40	conduction disease	12.8	MAOA, SLC6A3, SLC6A4
41	alexithymia	12.8	IL6, COMT, TTF2, SLC6A4
42	hermaphroditism	12.8	HTR1A, HTR1B, HTR1D, TPH1, TPH2
43	attention deficit hyperactivity disorder	12.7	TPH2, SLC6A3
44	metachromatic leukodystrophy	12.7	HTR1A, SLC6A3, SLC6A4
45	amnestic disorder	12.7	HTR1A, HTR3A
46	panic disorder	12.7	HTR1A, HTR3A, CRH, SLC6A4
47	adrenal gland hyperfunction	12.7	BGLAP, CRH, PRL
48	myoclonus	12.7	HTR1A, HTR1D, HTR2A, HTR2C
49	balanitis	12.7	BGLAP, BDNF, IL6
50	melancholia	12.7	MAOA, CRH, PRL, SLC6A4

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to borderline personality disorder:

²²

MGI Mouse Phenotypes related to borderline personality disorder:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.7	HTR1B, HTR2A
2	cardiovascular system phenotype	MP:0005385	8.1	COMT, TPH2, TPH1, HTR1B, HTR1A, MAOA
3	muscle phenotype	MP:0005369	7.7	SLC6A4, SLC6A3, TPH1, HTR2C, HTR2A, HTR1B
4	integument phenotype	MP:0010771	6.3	SLC6A4, SLC6A3, PRL, CRH, TPH2, TPH1
5	growth/size phenotype	MP:0005378	6.2	SLC6A4, SLC6A3, CRH, TPH2, TPH1, HTR3A
6	nervous system phenotype	MP:0003631	6.1	CRH, COMT, PRL, SLC6A3, SLC6A4, TPH2
7	homeostasis/metabolism phenotype	MP:0005376	5.6	CRH, COMT, PRL, SLC6A3, SLC6A4, TPH2
8	behavior/neurological phenotype	MP:0005386	4.6	BDNF, SLC6A4, SLC6A3, PRL, COMT, CRH

Articles related to borderline personality disorder:

(show all 24)

id	Title	Authors	Year	Affiliating Genes
1	Lack of modulating effects of the COMT Val(158)Met po lymorphism on the association of serious life events (SLE) and impulsivity in p atients with Borderline Personality Disorder. (19646713)	Wagner S.... TadiA8 A.	2010	COMT
2	The catechol o-methyltransferase (COMT) val(158)met p olymorphism modulates the association of serious life events (SLE) and impulsiv e aggression in female patients with borderline personality disorder (BPD). (19906087)	Wagner S.... TadiA8 A.	2010	COMT
3	Modulatory role of the brain-derived neurotrophic fac tor ValMet polymorphism on the effects of serious life events on impulsive aggr ession in borderline personality disorder. (19817874)	Wagner S.... TadiA8 A.	2009	BDNF
4	The 5-HTTLPR Polymorphism modulates the association of serious life events (SLE) and impulsivity in patients with Borderline Personality Disorder. (19358998)	Wagner S.... TadiA8 A.	2009	SLC6A4
5	Association analysis of SCN9A gene variants with borderline personality disorder. (18439623)	Tadic A.... Dahmen N.	2008	SCN9A
6	The tryptophan hydroxylase-1 A218C polymorphism is associated with diagnosis, but not suicidal behavior, in borderline personality disorder. (18506706)	Wilson S.T.... Mann J.J.	2008	TPH1
7	Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study. (19032968)	Ni X.... Kennedy J.L.	2008	HTR2C, MAOA, HTR1B
8	Failure to detect an association between the serotonin transporter gene and borderline personality disorder. (17137596)	Pascual J.C.... Baiget M.	2008	SLC6A4
9	5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder. (18387137)	Zetzsche T.... Meisenzahl E.M.	2008	HTR1A
10	Interaction between gene variants of the serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT) in borderline personality disorder. (18756498)	Tadic A.... Dahmen N.	2008	COMT, SLC6A4
11	Emotionally controlled decision-making and a gene variant related to serotonin synthesis in women with borderline personality disorder. (18826425)	Maurex L.... Ohman A.	2008	TPH1
12	Serotonin transporter polymorphism and fluoxetine effect on impulsiveness and aggression in borderline personality disorder. (17597424)	Silva H.... Roa N.	2007	SLC6A4
13	Association between the serotonin transporter gene and personality traits in borderline personality disorder patients evaluated with Zuckerman-Zuhlman Personality Questionnaire (ZKPQ). (18004675)	Pascual J.C.... Perez V.	2007	SLC6A4
14	Monoamine oxidase a gene is associated with borderline personality disorder. (17417058)	Ni X.... Kennedy J.L.	2007	MAOA
15	A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients. (16623961)	Joyce P.R.... Kennedy M.A.	2006	SLC6A3
16	Bone mineral density, bone turnover, and osteoprotegerin in depressed women with and without borderline personality disorder. (17012519)	Kahl K.G.... Schweiger U.	2006	BGLAP
17	Exploratory factor analysis of borderline personality disorder criteria in hospitalized adolescents. (16490567)	Becker D.F.... Grilo C.M.	2006	TTF2
18	Association between serotonin transporter gene and borderline personality disorder. (16690085)	Ni X.... Kennedy J.L.	2006	SLC6A4
19	Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder. (17000047)	Ni X.... Kennedy J.L.	2006	HTR2A
20	Bone mineral density, markers of bone turnover, and cytokines in young women with borderline personality disorder with and without comorbid major depressive disorder. (15625216)	Kahl K.G.... Schweiger U.	2005	BGLAP
21	Visceral fat deposition and insulin sensitivity in depressed women with and without comorbid borderline personality disorder. (15911903)	Kahl K.G.... Schweiger U.	2005	IL6
22	A possible effect of amisulpride on a prolactinoma gr owth in a woman with borderline personality disorder. (15225684)	Perroud N.... Huguelet P.	2004	PRL
23	Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in fe male borderline personality disorder subjects with a history of sustained child hood abuse. (12460693)	Rinne T.... van den Brink W.	2002	CRH
24	5-HT1A dysfunction in borderline personality disorder . (12171388)	Hansenne M.... Ansseau M.	2002	PRL, HTR1A

Genes related to borderline personality disorder according to GeneCards:

(show all 19)

id	Symbol	Description	Score	GeneCards Section Context
1	TTF2	transcription termination factor, RNA polymerase II	11.0	Publications
2	MAOA	monoamine oxidase A	11.0	Publications
3	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
4	HTR1D	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	11.0	Publications
5	TPH1	tryptophan hydroxylase 1	11.0	Publications
6	HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	11.0	Publications
7	TPH2	tryptophan hydroxylase 2	11.0	Publications
8	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	11.0	Publications
9	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit	11.0	Publications
10	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
11	PRL	prolactin	11.0	Publications
12	BDNF	brain-derived neurotrophic factor	11.0	Publications
13	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
14	COMT	catechol-O-methyltransferase	11.0	Publications
15	CRH	corticotropin releasing hormone	11.0	Publications
16	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
17	HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	11.0	Publications
18	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
19	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to borderline personality disorder according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Tryptophan metabolism20	9.8	MAOA, TPH1, TPH2
2	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	8.6	MAOA, HTR1A, HTR1D, HTR2A, TPH1, TPH2
3	Amine ligand-binding receptors38	8.6	HTR2C, HTR2A, HTR1D, HTR1B, HTR1A
4	Neuroactive ligand-receptor interaction20	8.0	PRL, HTR2C, HTR2A, HTR1D, HTR1B, HTR1A
5	Intracellular Calcium Signaling36	6.8	HTR3A, HTR2C, HTR2A, HTR1D, HTR1B, HTR1A

Compounds related to borderline personality disorder according to GeneDecks:

(show top 50)    (show all 250)

id	Compound	Score	Top Affiliating Genes
1	yohimbine32 9 9	11.3	CRH, HTR2C, HTR1D, HTR1A
2	mdma32	9.2	SLC6A4, PRL, HTR1A, MAOA, TPH1, SLC6A3
3	bromocriptine32 9 9	11.1	HTR2A, HTR1A, HTR2C, PRL
4	naratriptan32 9 9	11.0	MAOA, HTR1A, HTR1B, HTR2A, HTR1D
5	mhpg32	8.8	BDNF, MAOA, CRH, PRL, SLC6A4, COMT
6	homovanillic acid32 18	9.7	BDNF, SLC6A4, MAOA, TPH1, CRH, COMT
7	cyanopindolol32	8.5	HTR1B, HTR2A, HTR3A, HTR1D, HTR1A
8	lisuride32 9 9	10.5	PRL, HTR2C, HTR2A, HTR1D, HTR1A, HTR1B
9	levodopa32 9 9	10.4	HTR1A, BDNF, MAOA, HTR1B, TPH1, COMT
10	methiothepin32	8.4	HTR1B, HTR1D, HTR2A, HTR3A, HTR1A
11	pindolol32 9 9	10.4	HTR3A, HTR1A, HTR2A, PRL, HTR1B, SLC6A4
12	ropinirole32 9 9	10.3	HTR1B, HTR2A, HTR2C, COMT, HTR1A, HTR1D
13	sertraline32 34 9 18 9	12.3	MAOA, HTR1A, HTR3A, CRH, SLC6A3, SLC6A4
14	pergolide32 9 9	10.3	COMT, HTR2C, HTR2A, HTR1D, HTR1B, HTR1A
15	cabergoline32 9 9	10.3	PRL, COMT, HTR2C, HTR2A, HTR1D, HTR1B
16	1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane32	8.2	HTR1A, HTR3A, HTR2C, HTR2A, HTR1B
17	m-chlorophenylpiperazine32	8.1	HTR1A, SLC6A4, PRL, HTR3A, HTR2C, HTR2A
18	mianserin32 9 9	10.1	MAOA, SLC6A4, HTR3A, HTR2C, HTR2A, HTR1A
19	5-carboxamidotryptamine32	8.1	HTR2C, HTR3A, HTR2A, HTR1A, HTR1D, HTR1B
20	sumatriptan32 34 9 18 9	12.1	HTR3A, HTR2A, HTR1D, MAOA, HTR1A, HTR1B
21	5-hydroxytryptophan32	8.0	SLC6A4, PRL, CRH, TPH1, HTR3A, HTR2A
22	methysergide32 9 9	10.0	HTR3A, HTR2C, HTR2A, HTR1D, HTR1B, HTR1A
23	nefazodone34 32 9 9	11.0	HTR1A, HTR2A, HTR2C, HTR3A, SLC6A3, SLC6A4
24	apomorphine32 9 9	10.0	COMT, HTR2C, HTR2A, HTR1D, HTR1B, HTR1A
25	venlafaxine32 34 9 18 9	11.9	SLC6A4, SLC6A3, TPH2, HTR3A, HTR2A, BDNF
26	fluvoxamine32 34 9 9	10.9	BDNF, SLC6A4, MAOA, HTR1A, HTR2A, HTR3A
27	mcpp32	7.9	HTR3A, HTR2C, HTR2A, HTR1B, HTR1A, PRL
28	ritanserin32	7.9	PRL, HTR3A, HTR2C, HTR2A, HTR1D, HTR1B
29	metergoline32	7.9	PRL, HTR3A, HTR2C, HTR2A, HTR1D, HTR1B
30	ipsapirone32	7.9	PRL, HTR3A, HTR2C, HTR2A, HTR1D, HTR1B
31	aripiprazole32 34 9 18 9	11.8	HTR2A, HTR1D, PRL, HTR3A, HTR2C, HTR1B
32	ziprasidone32 9 9	9.8	HTR1A, HTR1D, HTR2A, HTR2C, HTR1B, PRL
33	amine32	7.7	MAOA, HTR1D, HTR2C, COMT, HTR3A, TPH1
34	mirtazapine32 34 9 9	10.7	SLC6A4, PRL, CRH, TPH2, HTR3A, HTR2C
35	ketanserin32	7.7	SLC6A4, HTR3A, HTR2C, HTR2A, HTR1D, HTR1B
36	pramipexole32 9 9	9.7	SLC6A3, PRL, COMT, HTR2C, HTR2A, HTR1D
37	clozapine32 34 9 9	10.6	HTR3A, HTR2C, HTR2A, HTR1D, HTR1A, PRL
38	imipramine32 34 9 18 9	11.5	BDNF, MAOA, SLC6A4, HTR1A, HTR2A, HTR3A
39	paroxetine32 34 9 9	10.4	SLC6A3, PRL, COMT, TPH1, HTR3A, HTR2A
40	quetiapine32 9 18 9	10.2	SLC6A3, PRL, HTR3A, HTR2C, HTR2A, HTR1D
41	fenfluramine32 9 9	9.2	SLC6A4, PRL, CRH, TPH1, HTR3A, HTR2C
42	maoa32	7.2	TPH1, TPH2, COMT, SLC6A4, BDNF, HTR2C
43	clomipramine32 34 9 9	10.2	HTR2C, HTR2A, HTR1A, MAOA, HTR3A, CRH
44	olanzapine32 34 9 18 9	10.8	SLC6A3, PRL, COMT, HTR3A, HTR2C, HTR2A
45	risperidone32 34 9 18 9	10.8	HTR2A, HTR3A, COMT, PRL, SLC6A3, SLC6A4
46	citalopram32 34 9 18 9	10.6	HTR1A, MAOA, BDNF, HTR2A, HTR2C, HTR3A
47	fluoxetine32 34 9 9	9.1	BDNF, SLC6A4, SLC6A3, PRL, CRH, TPH2
48	5-hydroxytryptamine32	5.8	HTR2C, SLC6A4, SLC6A3, PRL, COMT, CRH
49	dopamine32 9 18 9	8.7	SLC6A4, SLC6A3, PRL, COMT, CRH, TPH1
50	norepinephrine32 9 18 9	8.4	BDNF, SLC6A4, SLC6A3, PRL, COMT, CRH

Cellular components related to borderline personality disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	7.9	HTR1A, HTR1B, HTR1D, HTR2A, HTR3A, SLC6A3

Biological processes related to borderline personality disorder according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	serotonin biosynthetic process	GO:042427	10.2	TPH1, TPH2
2	aromatic amino acid family metabolic process	GO:009072	10.2	TPH1, TPH2
3	indolalkylamine biosynthetic process	GO:046219	10.2	TPH1, TPH2
4	monoamine transport	GO:015844	10.2	SLC6A4, SLC6A3
5	bone remodeling	GO:046849	10.1	HTR1B, TPH1
6	neurotransmitter catabolic process	GO:042135	10.0	MAOA, COMT
7	dopamine catabolic process	GO:042420	9.9	MAOA, COMT, SLC6A3
8	response to toxin	GO:009636	9.9	SLC6A4, HTR1D, SCN9A
9	negative regulation of synaptic transmission, glutamatergic	GO:051967	9.9	HTR1B, HTR2A
10	neurotransmitter biosynthetic process	GO:042136	9.9	MAOA, COMT, SLC6A3
11	regulation of dopamine secretion	GO:014059	9.7	HTR1B, HTR2A
12	response to cocaine	GO:042220	9.4	HTR1B, HTR3A, SLC6A3
13	response to glucocorticoid stimulus	GO:051384	9.3	BGLAP, IL6, TPH2
14	feeding behavior	GO:007631	9.3	CRH, HTR2C, BDNF
15	response to ethanol	GO:045471	9.3	BGLAP, HTR1B, SLC6A3
16	female pregnancy	GO:007565	9.2	PRL, COMT, CRH
17	serotonin receptor signaling pathway	GO:007210	8.8	HTR3A, HTR2C, HTR2A
18	response to drug	GO:042493	7.8	SLC6A4, SLC6A3, COMT, HTR2C, HTR2A, HTR1B
19	synaptic transmission	GO:007268	7.0	MAOA, SLC6A3, COMT, CRH, HTR3A, HTR2C

Molecular functions related to borderline personality disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	monoamine transmembrane transporter activity	GO:008504	10.0	SLC6A3, SLC6A4
2	tryptophan 5-monooxygenase activity	GO:004510	9.9	TPH1, TPH2
3	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	GO:071886	9.0	HTR2A, HTR2C
4	drug binding	GO:008144	8.5	SLC6A3, HTR2C, HTR2A, HTR1B, HTR1A
5	serotonin receptor activity	GO:004993	7.8	HTR3A, HTR2C, HTR2A, HTR1D, HTR1B, HTR1A
6	serotonin binding	GO:051378	7.7	MAOA, HTR3A, HTR2C, HTR2A, HTR1D, HTR1B