Aliases & Classifications for Borna Disease

Aliases & Descriptions for Borna Disease:

Name: Borna Disease 12 42 14 69
Enzootic Encephalomyelitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5154
MeSH 42 D001890
SNOMED-CT 64 76851008
UMLS 69 C0006023

Summaries for Borna Disease

Disease Ontology : 12 A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located in central nervous system, has material basis in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has symptom mood disturbances, has symptom behaviour disturbances, has symptom cognitive disturbances, has symptom neurologic disturbances, and has symptom movement impairment.

MalaCards based summary : Borna Disease, also known as enzootic encephalomyelitis, is related to neuronitis and schizophrenia, and has symptoms including mood disturbances, behaviour disturbances and cognitive disturbances. An important gene associated with Borna Disease is TBK1 (TANK Binding Kinase 1), and among its related pathways/superpathways are Regulation of retinoblastoma protein and Notch Signaling Pathway (sino). The drugs Pioglitazone and Rosiglitazone have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and cerebellum, and related phenotypes are Increased viability after borna disease (rVSVI9G*/BDVG) virus infection and cardiovascular system

Wikipedia : 71 Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease... more...

Related Diseases for Borna Disease

Diseases related to Borna Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
id Related Disease Score Top Affiliating Genes
1 neuronitis 10.3
2 schizophrenia 10.2
3 encephalitis 10.1
4 chronic fatigue syndrome 10.0
5 mood disorder 9.9
6 brain injury 9.8
7 autism spectrum disorder 9.8
8 obesity 9.6
9 obsessive-compulsive disorder 9.6
10 bipolar disorder 9.6
11 leukemia 9.6
12 meningoencephalitis 9.6
13 rabies 9.6
14 chlamydia 9.6
15 dementia 9.6
16 epilepsy 9.6
17 lateral sclerosis 9.6
18 psychotic disorder 9.6
19 oligodendroglioma 9.6
20 retinitis 9.6
21 dystonia 9.6
22 pneumonia 9.6
23 viral encephalitis 9.6
24 t-cell leukemia 9.6
25 influenza 9.6
26 stomatitis 9.6
27 allergic encephalomyelitis 9.6
28 human t-cell leukemia virus type 1 9.6
29 ataxia 9.6
30 arteriolosclerosis 8.4 ADAMTS10 AXL CHMP1A CKM CPA1 CTBP1

Graphical network of the top 20 diseases related to Borna Disease:



Diseases related to Borna Disease

Symptoms & Phenotypes for Borna Disease

Symptoms:

12
  • mood disturbances
  • behaviour disturbances
  • cognitive disturbances
  • neurologic disturbances
  • movement impairment

UMLS symptoms related to Borna Disease:


lameness, animal

GenomeRNAi Phenotypes related to Borna Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability after borna disease (rVSVI9G*/BDVG) virus infection GR00192-A 9.32 ADAMTS10 AXL CHMP1A CKM CPA1 CTBP1

MGI Mouse Phenotypes related to Borna Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 AXL CKM CTBP1 EDNRB FURIN TBK1

Drugs & Therapeutics for Borna Disease

Drugs for Borna Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 136)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pioglitazone Approved, Investigational Phase 4,Phase 3 111025-46-8 4829
2
Rosiglitazone Approved, Investigational Phase 4,Phase 3 122320-73-4 77999
3
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
4 Adrenergic Agents Phase 4,Phase 3
5 Adrenergic Agonists Phase 4,Phase 3
6 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 3
7 Adrenergic beta-Agonists Phase 4,Phase 3
8 Anti-Asthmatic Agents Phase 4,Phase 3
9 Anticonvulsants Phase 4
10 Autonomic Agents Phase 4,Phase 3
11 Bromides Phase 4,Phase 3
12 Bronchodilator Agents Phase 4,Phase 3
13 Cholinergic Agents Phase 4,Phase 3
14 Cholinergic Antagonists Phase 4,Phase 3
15 Neurotransmitter Agents Phase 4,Phase 3
16 Parasympatholytics Phase 4,Phase 3
17 Peripheral Nervous System Agents Phase 4,Phase 3
18 Respiratory System Agents Phase 4,Phase 3
19
Salmeterol xinafoate Phase 4,Phase 3 94749-08-3 56801
20 Tiotropium Bromide Phase 4,Phase 3 136310-93-5
21 insulin Phase 4
22 Insulin, Globin Zinc Phase 4
23 Fingolimod Hydrochloride Phase 4
24 Immunosuppressive Agents Phase 4,Phase 3
25 Hypoglycemic Agents Phase 4,Phase 3
26 2,4-thiazolidinedione Phase 4
27 Bone Density Conservation Agents Phase 4
28 Ergocalciferols Phase 4
29 Micronutrients Phase 4
30 Trace Elements Phase 4
31 vitamin d Phase 4
32 Vitamins Phase 4
33 Calciferol Nutraceutical Phase 4
34 Orange Nutraceutical Phase 4
35 Vitamin D2 Nutraceutical Phase 4
36
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
37
rituximab Approved Phase 3 174722-31-7 10201696
38
Glimepiride Approved Phase 3 93479-97-1 3476
39
Metformin Approved Phase 3 657-24-9 14219 4091
40
Lansoprazole Approved, Investigational Phase 3 103577-45-3 3883
41
Ezetimibe Approved Phase 3 163222-33-1 150311
42
Fenofibrate Approved Phase 3 49562-28-9 3339
43
Budesonide Approved Phase 3 51333-22-3 63006 5281004
44
Montelukast Approved Phase 3 158966-92-8 5281040
45
Terbutaline Approved Phase 3 23031-25-6 5403
46
Theophylline Approved Phase 3 58-55-9 2153
47
Fluorouracil Approved Phase 3 51-21-8 3385
48
Irinotecan Approved, Investigational Phase 3 97682-44-5, 100286-90-6 60838
49
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 6857599, 9887054 43805
50
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143

Interventional clinical trials:

(show all 35)
id Name Status NCT ID Phase
1 Tiotropium Once Daily 18 Mcg Versus Salmeterol Twice Daily 50 Mcg on Time to First Exacerbation in COPD Patients. Completed NCT00563381 Phase 4
2 Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation Completed NCT01164592 Phase 4
3 Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343 Phase 4
4 Blood Glucose Self Monitoring and HbA1c Effects on Glucose Control Completed NCT00688363 Phase 4
5 STudy to vAlidate telemetRic ECG Systems for firsT Dose Administration of Fingolimod (START) Completed NCT01585298 Phase 4
6 Thiazolidinedione Intervention With Vitamin D Evaluation Terminated NCT00879970 Phase 4
7 The Effect of QVA149 on Health Related Quality of Life in Patients With Chronic Obstructive Pulmonary Disease (COPD) Completed NCT01574651 Phase 3
8 A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease Completed NCT00501059 Phase 3
9 Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older Completed NCT00753272 Phase 3
10 A Study of MabThera (Rituximab) in Patients With Advanced Non-Hodgkin's Lymphoma Completed NCT00269113 Phase 3
11 Efficacy of Pioglitazone/Metformin Combination Therapy in Subjects With Type 2 Diabetes Mellitus and Dyslipidemia. Completed NCT00770653 Phase 3
12 Secukinumab Dosage Optimisation in Partial Responders With Moderate to Severe Plaque-type Psoriasis Completed NCT02474069 Phase 3
13 Rosiglitazone on Microalbuminuria in Type 2 Diabetics Completed NCT00500955 Phase 3
14 Efficacy and Safety of Dexlansoprazole MR and Lansoprazole on Healing of Erosive Esophagitis Completed NCT00251693 Phase 3
15 A Controlled-Study of Fenofibrate 145 mg and Ezetimibe 10 mg in Type IIb Dyslipidemic Patients With Features of the Metabolic Syndrome Completed NCT00349284 Phase 3
16 DESOLO - SiT Peri-Launch: A Comparison of Symbicort Single Inhaler Therapy and Conventional Best Practice for the Treatment of Persistent Asthma in Adults Completed NCT00252863 Phase 3
17 Phase 3 Trial of Litx™ Plus Chemotherapy vs. Chemotherapy Only Treating Colorectal Cancer Patients With Recurrent Liver Metastases Completed NCT00440310 Phase 3
18 Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events) Active, not recruiting NCT01327846 Phase 3
19 Fenofibrate and Metformin Fixed Combination vs Rosiglitazone - FAME ROSI Terminated NCT00361868 Phase 3
20 Non-interventional Observational Study With Pramipexole: Impact on Non-motor Symptoms in Parkinson's Disease Completed NCT00539214
21 Efficacy of Pantoprazole in Patients Older Than 12 Years With Reflux Associated Sleep Disorders (PULS) Completed NCT00562094
22 Efficacy of Pantoprazole 20/40 mg Once Daily (od) in Patients Older Than 12 Years Who Have Gastrointestinal Symptoms of Reflux Disease Completed NCT00829738
23 Prospective, Study for the Use of Palivizumab (Synagis) in High Risk Children in Germany Completed NCT01155193
24 Non-interventional Observational Study of Pramipexole in Restless Legs Syndrome: Impact on Quality of Life Completed NCT00539461
25 Quality of Life in Daxas-treated Patients Older Than 18 Years With Severe COPD Completed NCT01285180
26 A German Study Evaluating the Efficacy and the Benefit of Integrated Personalized Diabetes Management (PDM) for Type 2 Diabetes Patients. Completed NCT02268929
27 Matrifen® for Therapy of Severe Chronic Pain® Completed NCT00699335
28 Dabigatran Etexilate for Stroke Prevention in Patients With Atrial Fibrillation and Mild to Moderate Renal Impairment Completed NCT01721837
29 Arimidex: Compliance and Arthralgias in Clinical Therapy (COMPACT) Completed NCT00857012
30 Comparison of Axillary Sentinel Lymph Node Biopsy Versus no Axillary Surgery Recruiting NCT02466737
31 Documentation of Humira in Psoriasis Patients in Routine Clinical Practice Recruiting NCT01077232
32 A Study To Evaluate The Efficacy Of Enbrel (REGISTERED) Etanercept Over A Period Of 12 Months In The Routine Treatment Of Patients With Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis, Or Plaque Psoriasis. Recruiting NCT02486302
33 Validation of Brain Function Assessment Algorithm for mTBI From Injury to Rehabilitation in College Athletes Recruiting NCT02957461
34 Double-blind Placebo-controlled Pilot Study of Sirolimus in Idiopathic Pulmonary Fibrosis (IPF) Active, not recruiting NCT01462006
35 Efficacy of an Internet-based Treatment for Flying Phobia: NO-FEAR Airlines Active, not recruiting NCT02298478

Search NIH Clinical Center for Borna Disease

Cochrane evidence based reviews: borna disease

Genetic Tests for Borna Disease

Anatomical Context for Borna Disease

MalaCards organs/tissues related to Borna Disease:

39
Brain, T Cells, Cerebellum, Retina, Cortex, Pituitary, Prefrontal Cortex

The Foundational Model of Anatomy Ontology organs/tissues related to Borna Disease:

18
Central Nervous System

Publications for Borna Disease

Articles related to Borna Disease:

(show top 50) (show all 528)
id Title Authors Year
1
Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. ( 27748825 )
2016
2
Neuronal retrograde transport of Borna disease virus occurs in signalling endosomes. ( 27902378 )
2016
3
Detection of antibodies to Borna disease virus proteins in an autistic child and her mother. ( 27795475 )
2016
4
Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus. ( 27803166 )
2016
5
Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. ( 26700735 )
2016
6
Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia. ( 28050187 )
2016
7
Primary psychosis and Borna disease virus infection in Lithuania: a case control study. ( 27809822 )
2016
8
Sero-epidemiological analysis of vertical transmission relative risk of Borna disease virus infection in dairy herds. ( 27498995 )
2016
9
X-linked RNA-binding motif protein (RBMX) is required for the maintenance of Borna disease virus nuclear viral factories. ( 26333388 )
2015
10
Borna disease virus possesses an NF-A,B inhibitory sequence in the nucleoprotein gene. ( 25733193 )
2015
11
Borna disease virus phosphoprotein impairs the developmental program controlling neurogenesis and reduces human GABAergic neurogenesis. ( 25923687 )
2015
12
Borna disease virus infection impacts microRNAs associated with nervous system development, cell differentiation, proliferation and apoptosis in the hippocampi of neonatal rats. ( 26004383 )
2015
13
Shedding of Infectious Borna Disease Virus-1 in Living Bicolored White-Toothed Shrews. ( 26313904 )
2015
14
GC-MS-Based Metabonomic Profiling Displayed Differing Effects of Borna Disease Virus Natural Strain Hu-H1 and Laboratory Strain V Infection in Rat Cortical Neurons. ( 26287181 )
2015
15
Discrepancy in the diagnosis of avian Borna disease virus infection of Psittaciformes by protein analysis of feather calami and enzyme-linked immunosorbent assay of plasma antibodies. ( 25701023 )
2015
16
Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. ( 25810554 )
2015
17
Borna disease virus infection in cats: ABCD guidelines on prevention and management. ( 26101313 )
2015
18
Neuropathogenesis of persistent infection with Borna disease virus. ( 26923969 )
2015
19
Health care professionals at risk of infection with Borna disease virus - evidence from a large hospital in China (Chongqing). ( 25888756 )
2015
20
Surface glycoprotein of Borna disease virus mediates virus spread from cell to cell. ( 26332529 )
2015
21
Persistent human Borna disease virus infection modifies the acetylome of human oligodendroglia cells towards higher energy and transporter levels. ( 26210075 )
2015
22
Proteomics reveal energy metabolism and mitogen-activated protein kinase signal transduction perturbation in human Borna disease virus Hu-H1-infected oligodendroglial cells. ( 24637096 )
2014
23
Human borna disease virus infection impacts host proteome and histone lysine acetylation in human oligodendroglia cells. ( 25086498 )
2014
24
Evidence for natural Borna disease virus infection in healthy domestic animals in three areas of western China. ( 24573218 )
2014
25
Heat stress is a potent stimulus for enhancing rescue efficiency of recombinant Borna disease virus. ( 25154584 )
2014
26
Subcellular localization of Borna disease virus proteins, P and X, after heat stress. BDV-infected OL cells were incubated at 40A^C for 12 hr. The cells were stained with anti-P (red) and anti-X (green) antibodies and counterstained with DAPI (blue). ( 25363744 )
2014
27
Borna disease virus infection in cats. ( 24480411 )
2014
28
Real-time qPCR identifies suitable reference genes for Borna disease virus-infected rat cortical neurons. ( 25431926 )
2014
29
Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome. ( 25157155 )
2014
30
Glutamate and lipid metabolic perturbation in the hippocampi of asymptomatic borna disease virus-infected horses. ( 24956478 )
2014
31
A study on Borna disease virus infection in domestic cats in Japan. ( 24805904 )
2014
32
The bicolored white-toothed shrew Crocidura leucodon (HERMANN 1780) is an indigenous host of mammalian Borna disease virus. ( 24699636 )
2014
33
Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran. ( 25186971 )
2014
34
Nucleocytoplasmic shuttling of viral proteins in borna disease virus infection. ( 23965528 )
2013
35
Borna disease virus-induced neuronal degeneration dependent on host genetic background and prevented by soluble factors. ( 23319640 )
2013
36
Human but Not Laboratory Borna Disease Virus Inhibits Proliferation and Induces Apoptosis in Human Oligodendrocytes In Vitro. ( 23805250 )
2013
37
Borna disease virus encoded phosphoprotein inhibits host innate immunity by regulating miR-155. ( 23428672 )
2013
38
Landscape features and reservoir occurrence affecting the risk for equine infection with Borna disease virus. ( 24502713 )
2013
39
Bicolored white-toothed shrews as reservoir for borna disease virus, Bavaria, Germany. ( 24274262 )
2013
40
MAVS-mediated host cell defense is inhibited by Borna disease virus. ( 23702035 )
2013
41
Borna disease virus nucleoprotein inhibits type I interferon induction through the interferon regulatory factor 7 pathway. ( 23939047 )
2013
42
Epidemiology and host spectrum of Borna disease virus infections. ( 23223618 )
2013
43
Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces. ( 24170181 )
2013
44
Absence of a robust innate immune response in rat neurons facilitates persistent infection of Borna disease virus in neuronal tissue. ( 23793543 )
2013
45
Analysis of borna disease virus trafficking in live infected cells by using a virus encoding a tetracysteine-tagged p protein. ( 24027309 )
2013
46
The influence of Borna disease viral infection on dairy cow reproduction. ( 22123302 )
2012
47
Markers of Borna disease virus infection in cats with staggering disease. ( 22553310 )
2012
48
Borna disease virus infects human neural progenitor cells and impairs neurogenesis. ( 22190725 )
2012
49
TNF-overexpression in Borna disease virus-infected mouse brains triggers inflammatory reaction and epileptic seizures. ( 22848506 )
2012
50
Serological evidence for infections with Borna disease virus in Turkey. ( 23227761 )
2012

Variations for Borna Disease

Expression for Borna Disease

Search GEO for disease gene expression data for Borna Disease.

Pathways for Borna Disease

Pathways related to Borna Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.7 CKM CTBP1
2 10.34 CTBP1 FURIN TBK1

GO Terms for Borna Disease

Cellular components related to Borna Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endosome membrane GO:0010008 8.8 CHMP1A FURIN TBK1

Biological processes related to Borna Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.56 ADAMTS10 CHMP1A CPA1 FURIN
2 viral process GO:0016032 9.26 AXL CTBP1 FDPS TBK1
3 animal organ regeneration GO:0031100 9.16 AXL FPGS
4 secretion by cell GO:0032940 8.62 AXL FURIN

Molecular functions related to Borna Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 8.8 ADAMTS10 CHMP1A CPA1

Sources for Borna Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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