Aliases & Classifications for Borna Disease

MalaCards integrated aliases for Borna Disease:

Name: Borna Disease 12 42 14 69
Enzootic Encephalomyelitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5154
MeSH 42 D001890
SNOMED-CT 64 76851008
UMLS 69 C0006023

Summaries for Borna Disease

Disease Ontology : 12 A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located in central nervous system, has material basis in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has symptom mood disturbances, has symptom behaviour disturbances, has symptom cognitive disturbances, has symptom neurologic disturbances, and has symptom movement impairment.

MalaCards based summary : Borna Disease, also known as enzootic encephalomyelitis, is related to neuronitis and schizophrenia, and has symptoms including lameness, animal An important gene associated with Borna Disease is HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5), and among its related pathways/superpathways are Regulation of retinoblastoma protein and Notch Signaling Pathway (sino). The drugs Pioglitazone and Rosiglitazone have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and cardiovascular system

Wikipedia : 72 Mammalian 1... more...

Related Diseases for Borna Disease

Diseases related to Borna Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
id Related Disease Score Top Affiliating Genes
1 neuronitis 10.3
2 schizophrenia 10.2
3 encephalitis 10.1
4 chronic fatigue syndrome 10.0
5 mood disorder 9.9
6 brain injury 9.8
7 autism spectrum disorder 9.8
8 obesity 9.6
9 obsessive-compulsive disorder 9.6
10 bipolar disorder 9.6
11 leukemia 9.6
12 meningoencephalitis 9.6
13 rabies 9.6
14 chlamydia 9.6
15 dementia 9.6
16 epilepsy 9.6
17 lateral sclerosis 9.6
18 psychotic disorder 9.6
19 oligodendroglioma 9.6
20 retinitis 9.6
21 dystonia 9.6
22 pneumonia 9.6
23 viral encephalitis 9.6
24 t-cell leukemia 9.6
25 influenza 9.6
26 stomatitis 9.6
27 allergic encephalomyelitis 9.6
28 human t-cell leukemia virus type 1 9.6
29 ataxia 9.6
30 pleural cancer 5.8 ABCB5 ADAM17 AXL CHMP1A CKM CTBP1

Graphical network of the top 20 diseases related to Borna Disease:



Diseases related to Borna Disease

Symptoms & Phenotypes for Borna Disease

UMLS symptoms related to Borna Disease:


lameness, animal

GenomeRNAi Phenotypes related to Borna Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.23 ADAM17
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.23 ADAM17 FURIN
3 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.23 ADAM17 FPGS FURIN
4 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.23 FURIN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.23 FURIN ADAM17 FPGS
6 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.23 FURIN
7 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.23 FURIN
8 Increased shRNA abundance (Z-score > 2) GR00366-A-41 10.23 FURIN
9 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.23 FURIN ADAM17
10 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.23 FPGS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-54 10.23 FPGS
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.23 FURIN
13 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.23 ADAM17
14 Decreased viability GR00221-A-1 10.22 AXL TBK1
15 Decreased viability GR00221-A-2 10.22 AXL CKM HSPA5 TBK1
16 Decreased viability GR00221-A-4 10.22 AXL
17 Decreased viability GR00301-A 10.22 AXL HSPA5 TBK1
18 Decreased viability GR00342-S-1 10.22 TBK1
19 Decreased viability GR00342-S-2 10.22 TBK1
20 Increased viability after borna disease (rVSVI9G*/BDVG) virus infection GR00192-A 9.28 FDPS FPGS FURIN ABCB5 ADAM17 AXL

MGI Mouse Phenotypes related to Borna Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 TBK1 ADAM17 AXL CKM CTBP1 FURIN

Drugs & Therapeutics for Borna Disease

Drugs for Borna Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pioglitazone Approved, Investigational Phase 4,Phase 3 111025-46-8 4829
2
Rosiglitazone Approved, Investigational Phase 4,Phase 3 122320-73-4 77999
3
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
4 Orange Approved, Nutraceutical Phase 4
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
6
2,4-thiazolidinedione Investigational Phase 4 2295-31-0
7 Adrenergic Agents Phase 4,Phase 3
8 Adrenergic Agonists Phase 4,Phase 3
9 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 3
10 Adrenergic beta-Agonists Phase 4,Phase 3
11 Anti-Asthmatic Agents Phase 4,Phase 3
12 Anticonvulsants Phase 4
13 Autonomic Agents Phase 4,Phase 3
14 Bromides Phase 4,Phase 3
15 Bronchodilator Agents Phase 4,Phase 3
16 Cholinergic Agents Phase 4,Phase 3
17 Cholinergic Antagonists Phase 4,Phase 3
18 Neurotransmitter Agents Phase 4,Phase 3
19 Parasympatholytics Phase 4,Phase 3
20 Peripheral Nervous System Agents Phase 4,Phase 3
21 Respiratory System Agents Phase 4,Phase 3
22
Salmeterol xinafoate Phase 4 94749-08-3 56801
23 Tiotropium Bromide Phase 4,Phase 3 136310-93-5
24 insulin Phase 4
25 Insulin, Globin Zinc Phase 4
26 Hypoglycemic Agents Phase 4,Phase 3
27 Bone Density Conservation Agents Phase 4
28 Ergocalciferols Phase 4
29 Micronutrients Phase 4
30 Trace Elements Phase 4
31 Vitamins Phase 4
32 Calciferol Nutraceutical Phase 4
33 Vitamin D2 Nutraceutical Phase 4
34
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
35
rituximab Approved Phase 3 174722-31-7 10201696
36
Glimepiride Approved Phase 3 93479-97-1 3476
37
Metformin Approved Phase 3 657-24-9 14219 4091
38
Fenofibrate Approved Phase 3 49562-28-9 3339
39 Adjuvants, Anesthesia Phase 3
40 Anesthetics Phase 3
41 Formoterol Fumarate Phase 3
42
Glycopyrrolate Phase 3 596-51-0 3494
43 Muscarinic Antagonists Phase 3
44 Analgesics Phase 3
45 Analgesics, Non-Narcotic Phase 3
46 Anti-Inflammatory Agents Phase 3
47 Anti-Inflammatory Agents, Non-Steroidal Phase 3
48 Antipyretics Phase 3
49 Antirheumatic Agents Phase 3
50 Cyclooxygenase Inhibitors Phase 3

Interventional clinical trials:

(show all 26)

id Name Status NCT ID Phase Drugs
1 Tiotropium Once Daily 18 Mcg Versus Salmeterol Twice Daily 50 Mcg on Time to First Exacerbation in COPD Patients. Completed NCT00563381 Phase 4 Tiotropium bromide;Salmeterol;Placebo Salmeterol;Placebo Tiotropium
2 Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation Completed NCT01164592 Phase 4
3 Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343 Phase 4
4 Blood Glucose Self Monitoring and HbA1c Effects on Glucose Control Completed NCT00688363 Phase 4
5 Thiazolidinedione Intervention With Vitamin D Evaluation Terminated NCT00879970 Phase 4 pioglitazone;rosiglitazone;placebo
6 The Effect of QVA149 on Health Related Quality of Life in Patients With Chronic Obstructive Pulmonary Disease (COPD) Completed NCT01574651 Phase 3 QVA149;Placebo to tiotropium;Placebo to formoterol;Tiotropium;Formoterol;Placebo to QVA149
7 A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease Completed NCT00501059 Phase 3 Aspirin (Acetylsalicylic acid, BAYE4465);Placebo
8 Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older Completed NCT00753272 Phase 3
9 A Study of MabThera (Rituximab) in Patients With Advanced Non-Hodgkin's Lymphoma Completed NCT00269113 Phase 3 rituximab [MabThera/Rituxan];Standard chemotherapy
10 Efficacy of Pioglitazone/Metformin Combination Therapy in Subjects With Type 2 Diabetes Mellitus and Dyslipidemia. Completed NCT00770653 Phase 3 Pioglitazone and Metformin;Glimepiride and Metformin
11 Secukinumab Dosage Optimisation in Partial Responders With Moderate to Severe Plaque-type Psoriasis Completed NCT02474069 Phase 3 Secukinumab
12 Rosiglitazone on Microalbuminuria in Type 2 Diabetics Completed NCT00500955 Phase 3 Rosiglitazone
13 Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events) Active, not recruiting NCT01327846 Phase 3 Canakinumab;Placebo
14 Fenofibrate and Metformin Fixed Combination vs Rosiglitazone - FAME ROSI Terminated NCT00361868 Phase 3 fenofibrate (F) + metformin (M) hydrochloride fixed combination;Rosiglitazone
15 Non-interventional Observational Study With Pramipexole: Impact on Non-motor Symptoms in Parkinson's Disease Completed NCT00539214
16 Efficacy of Pantoprazole in Patients Older Than 12 Years With Reflux Associated Sleep Disorders (PULS) Completed NCT00562094 Pantoprazole
17 Efficacy of Pantoprazole 20/40 mg Once Daily (od) in Patients Older Than 12 Years Who Have Gastrointestinal Symptoms of Reflux Disease Completed NCT00829738 Pantoprazole
18 Prospective, Study for the Use of Palivizumab (Synagis) in High Risk Children in Germany Completed NCT01155193
19 Non-interventional Observational Study of Pramipexole in Restless Legs Syndrome: Impact on Quality of Life Completed NCT00539461
20 Quality of Life in Daxas-treated Patients Older Than 18 Years With Severe COPD Completed NCT01285180 Daxas
21 A German Study Evaluating the Efficacy and the Benefit of Integrated Personalized Diabetes Management (PDM) for Type 2 Diabetes Patients. Completed NCT02268929
22 Comparison of Axillary Sentinel Lymph Node Biopsy Versus no Axillary Surgery Recruiting NCT02466737
23 Documentation of Humira in Psoriasis Patients in Routine Clinical Practice Recruiting NCT01077232
24 A Study To Evaluate The Efficacy Of Enbrel (REGISTERED) Etanercept Over A Period Of 12 Months In The Routine Treatment Of Patients With Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis, Or Plaque Psoriasis. Recruiting NCT02486302 Etanercept
25 Double-blind Placebo-controlled Pilot Study of Sirolimus in Idiopathic Pulmonary Fibrosis (IPF) Active, not recruiting NCT01462006 sirolimus
26 Efficacy of an Internet-based Treatment for Flying Phobia: NO-FEAR Airlines Active, not recruiting NCT02298478

Search NIH Clinical Center for Borna Disease

Cochrane evidence based reviews: borna disease

Genetic Tests for Borna Disease

Anatomical Context for Borna Disease

MalaCards organs/tissues related to Borna Disease:

39
Brain, T Cells, Bone, Lymph Node, Heart, Cerebellum, Cortex

Publications for Borna Disease

Articles related to Borna Disease:

(show top 50) (show all 534)
id Title Authors Year
1
Infections of horses and shrews with Bornaviruses in Upper Austria: a novel endemic area of Borna disease. ( 28634359 )
2017
2
Detection of Antibodies against Borna Disease Virus Proteins in an Autistic Child and Her Mother. ( 28943599 )
2017
3
Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production. ( 28446679 )
2017
4
Linkage between the leader sequence and leader RNA production in Borna disease virus-infected cells. ( 28715652 )
2017
5
Generation of a non-transmissive Borna disease virus vector lacking both matrix and glycoprotein genes. ( 28776750 )
2017
6
Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein. ( 28693611 )
2017
7
Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia. ( 28050187 )
2016
8
Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. ( 26700735 )
2016
9
Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus. ( 27803166 )
2016
10
Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. ( 27748825 )
2016
11
Neuronal retrograde transport of Borna disease virus occurs in signalling endosomes. ( 27902378 )
2016
12
Primary psychosis and Borna disease virus infection in Lithuania: a case control study. ( 27809822 )
2016
13
Detection of antibodies to Borna disease virus proteins in an autistic child and her mother. ( 27795475 )
2016
14
Sero-epidemiological analysis of vertical transmission relative risk of Borna disease virus infection in dairy herds. ( 27498995 )
2016
15
Borna disease virus possesses an NF-A,B inhibitory sequence in the nucleoprotein gene. ( 25733193 )
2015
16
Borna disease virus infection in cats: ABCD guidelines on prevention and management. ( 26101313 )
2015
17
Discrepancy in the diagnosis of avian Borna disease virus infection of Psittaciformes by protein analysis of feather calami and enzyme-linked immunosorbent assay of plasma antibodies. ( 25701023 )
2015
18
Shedding of Infectious Borna Disease Virus-1 in Living Bicolored White-Toothed Shrews. ( 26313904 )
2015
19
Persistent human Borna disease virus infection modifies the acetylome of human oligodendroglia cells towards higher energy and transporter levels. ( 26210075 )
2015
20
Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. ( 25810554 )
2015
21
Surface glycoprotein of Borna disease virus mediates virus spread from cell to cell. ( 26332529 )
2015
22
GC-MS-Based Metabonomic Profiling Displayed Differing Effects of Borna Disease Virus Natural Strain Hu-H1 and Laboratory Strain V Infection in Rat Cortical Neurons. ( 26287181 )
2015
23
Borna disease virus phosphoprotein impairs the developmental program controlling neurogenesis and reduces human GABAergic neurogenesis. ( 25923687 )
2015
24
X-linked RNA-binding motif protein (RBMX) is required for the maintenance of Borna disease virus nuclear viral factories. ( 26333388 )
2015
25
Health care professionals at risk of infection with Borna disease virus - evidence from a large hospital in China (Chongqing). ( 25888756 )
2015
26
Neuropathogenesis of persistent infection with Borna disease virus. ( 26923969 )
2015
27
Borna disease virus infection impacts microRNAs associated with nervous system development, cell differentiation, proliferation and apoptosis in the hippocampi of neonatal rats. ( 26004383 )
2015
28
Subcellular localization of Borna disease virus proteins, P and X, after heat stress. BDV-infected OL cells were incubated at 40A^C for 12 hr. The cells were stained with anti-P (red) and anti-X (green) antibodies and counterstained with DAPI (blue). ( 25363744 )
2014
29
Proteomics reveal energy metabolism and mitogen-activated protein kinase signal transduction perturbation in human Borna disease virus Hu-H1-infected oligodendroglial cells. ( 24637096 )
2014
30
Heat stress is a potent stimulus for enhancing rescue efficiency of recombinant Borna disease virus. ( 25154584 )
2014
31
A study on Borna disease virus infection in domestic cats in Japan. ( 24805904 )
2014
32
Glutamate and lipid metabolic perturbation in the hippocampi of asymptomatic borna disease virus-infected horses. ( 24956478 )
2014
33
Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome. ( 25157155 )
2014
34
Evidence for natural Borna disease virus infection in healthy domestic animals in three areas of western China. ( 24573218 )
2014
35
Real-time qPCR identifies suitable reference genes for Borna disease virus-infected rat cortical neurons. ( 25431926 )
2014
36
Human borna disease virus infection impacts host proteome and histone lysine acetylation in human oligodendroglia cells. ( 25086498 )
2014
37
Borna disease virus infection in cats. ( 24480411 )
2014
38
The bicolored white-toothed shrew Crocidura leucodon (HERMANN 1780) is an indigenous host of mammalian Borna disease virus. ( 24699636 )
2014
39
Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran. ( 25186971 )
2014
40
Human but Not Laboratory Borna Disease Virus Inhibits Proliferation and Induces Apoptosis in Human Oligodendrocytes In Vitro. ( 23805250 )
2013
41
Epidemiology and host spectrum of Borna disease virus infections. ( 23223618 )
2013
42
Borna disease virus-induced neuronal degeneration dependent on host genetic background and prevented by soluble factors. ( 23319640 )
2013
43
Borna disease virus nucleoprotein inhibits type I interferon induction through the interferon regulatory factor 7 pathway. ( 23939047 )
2013
44
Landscape features and reservoir occurrence affecting the risk for equine infection with Borna disease virus. ( 24502713 )
2013
45
Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces. ( 24170181 )
2013
46
Borna disease virus encoded phosphoprotein inhibits host innate immunity by regulating miR-155. ( 23428672 )
2013
47
Absence of a robust innate immune response in rat neurons facilitates persistent infection of Borna disease virus in neuronal tissue. ( 23793543 )
2013
48
MAVS-mediated host cell defense is inhibited by Borna disease virus. ( 23702035 )
2013
49
Nucleocytoplasmic shuttling of viral proteins in borna disease virus infection. ( 23965528 )
2013
50
Bicolored white-toothed shrews as reservoir for borna disease virus, Bavaria, Germany. ( 24274262 )
2013

Variations for Borna Disease

Expression for Borna Disease

Search GEO for disease gene expression data for Borna Disease.

Pathways for Borna Disease

Pathways related to Borna Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.7 CKM CTBP1
2 10.34 ADAM17 CTBP1 TBK1

GO Terms for Borna Disease

Cellular components related to Borna Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endosome membrane GO:0010008 9.13 CHMP1A FURIN TBK1
2 cell surface GO:0009986 8.92 ADAM17 AXL FURIN HSPA5

Biological processes related to Borna Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.26 AXL CTBP1 FDPS TBK1
2 animal organ regeneration GO:0031100 9.16 AXL FPGS
3 secretion by cell GO:0032940 8.62 AXL FURIN

Molecular functions related to Borna Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.13 CHMP1A CTBP1 HSPA5
2 ATP binding GO:0005524 9.1 ABCB5 AXL CKM FPGS HSPA5 TBK1

Sources for Borna Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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