MCID: BRN018
MIFTS: 51

Borna Disease malady

Summaries for Borna Disease

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection, which affects dopaminergic neurotransmission located in central nervous system, has material basis in borna disease virus, which is transmitted by contact with infected oronasal secretions. the infection has symptom mood disturbances, has symptom behaviour disturbances, has symptom cognitive disturbances, has symptom neurologic disturbances, and has symptom movement impairment.

MalaCards: Borna Disease, also known as enzootic encephalomyelitis, is related to encephalitis and multiple sclerosis, and has symptoms including movement impairment, neurologic disturbances and cognitive disturbances. An important gene associated with Borna Disease is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are TCR signaling in naive CD4+ T cells and Downstream signaling in naive CD8+ T cells. The compounds delta-12-pgj2 and leupeptin have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, brain and t cells, and related mouse phenotypes are integument and normal.

Wikipedia:63 Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease... more...

Aliases & Classifications for Borna Disease

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

borna disease 8 10 60
enzootic encephalomyelitis 8


External Ids:

Disease Ontology8 DOID:5154
SNOMED-CT56 76851008
MeSH34 D001890

Related Diseases for Borna Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Borna Disease:



Diseases related to borna disease

Clinical Features for Borna Disease

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8Disease Ontology
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Symptoms:

8
  • movement impairment
  • neurologic disturbances
  • cognitive disturbances
  • behaviour disturbances
  • mood disturbances

Drugs & Therapeutics for Borna Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Borna Disease

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Anatomical Context for Borna Disease

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Borna Disease:

32
Brain, T cells, Cerebellum, Cortex, Retina, Prefrontal cortex, Bone marrow, Bone, Testes, Pituitary, Thymus

FMA organs/tissues related to Borna Disease:

14
Central nervous system

Animal Models for Borna Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Borna Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0HSPA5, S100A10, PRF1, TBK1, CD4
2MP:00028738.5FURIN, HSPA5, IFNG, PRDX6, PRF1, CD4
3MP:00036318.2IFNG, S100A10, PSMC1, PRF1, CD4, CD8A
4MP:00053767.6HSPA5, IFNG, S100A10, PSMC1, PRDX6, PRF1

Publications for Borna Disease

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50PubMed
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Articles related to Borna Disease:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
Borna disease virus nucleoprotein inhibits type I interferon induction through the interferon regulatory factor 7 pathway. (23939047)
2013
2
Epidemiology and host spectrum of Borna disease virus infections. (23223618)
2013
3
Absence of a robust innate immune response in rat neurons facilitates persistent infection of Borna disease virus in neuronal tissue. (23793543)
2013
4
Upregulation of insulin-like growth factor binding protein 3 in astrocytes of transgenic mice that express Borna disease virus phosphoprotein. (21325425)
2011
5
Intracerebral Borna disease virus infection of bank voles leading to peripheral spread and reverse transcription of viral RNA. (21935357)
2011
6
Borna disease virus antibody and RNA from peripheral blood mononuclear cells of race horses and jockeys in Korea. (21519538)
2011
7
Analysis of intracellular distribution of Borna disease virus glycoprotein fused with fluorescent markers in living cells. (21566396)
2011
8
Role of Borna disease virus in neuropsychiatric illnesses: are we inching closer? (19584498)
2009
9
Failure to detect borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients. (20140130)
2009
10
Protein X of Borna disease virus inhibits apoptosis and promotes viral persistence in the central nervous systems of newborn-infected rats. (19211764)
2009
11
Borna disease virus infection in the population of Latium (Italy). (18771104)
2008
12
Restricted expression of Borna disease virus glycoprotein in brains of experimentally infected Lewis rats. (18282160)
2008
13
Layer specific changes of astroglial gap junctions in the rat cerebellar cortex by persistent Borna Disease Virus infection. (18538309)
2008
14
Amantadine reduces mania in borna disease virus-infected non-psychotic bipolar patients. (18763224)
2008
15
Natural and experimental Borna disease virus infections--neuropathology and pathogenetic considerations. (18771099)
2008
16
Borna disease virus P protein inhibits nitric oxide synthase gene expression in astrocytes. (17543364)
2007
17
Preservation of RNA and destruction of infectivity in microdissected brain tissues of Lewis rats infected with the Borna disease virus. (16707170)
2006
18
Borna disease virus interference with neuronal plasticity. (15885838)
2005
19
Genome trimming: a unique strategy for replication control employed by Borna disease virus. (15728364)
2005
20
Mechanism of the antiviral action of 1-beta-D-arabinofuranosylcytosine on Borna disease virus. (15767452)
2005
21
Borna disease virus replication in organotypic hippocampal slice cultures from rats results in selective damage of dentate granule cells. (16140749)
2005
22
Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant. (15596826)
2005
23
Borna disease virus multiplication in mouse organotypic slice cultures is site-specifically inhibited by gamma interferon but not by interleukin-12. (14722276)
2004
24
Borna disease virus glycoprotein is required for viral dissemination in neurons. (14581559)
2003
25
A reverse genetics system for Borna disease virus. (14573815)
2003
26
Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice. (12857949)
2003
27
Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. I. Brain pathology and behavioral deficits. (12106670)
2002
28
Open reading frame III of borna disease virus encodes a nonglycosylated matrix protein. (11711600)
2001
29
Detection of anti-borna disease virus antibodies from cats in Asian countries, Japan, Philippines and Indonesia using electrochemiluminescence immunoassay. (11558551)
2001
30
Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan. (11158085)
2001
31
Distribution of Borna disease virus in the brain of rats infected with an obesity-inducing virus strain. (10668894)
2000
32
Neuron-glia interactions in the rat retina infected by Borna disease virus. (10664411)
2000
33
Borna disease virus-related therapy-resistant depression improved after cerebrospinal fluid filtration. (11165306)
2000
34
Molecular ratio between borna disease viral-p40 and -p24 proteins in infected cells determined by quantitative antigen capture ELISA. (11092240)
2000
35
Amantadine in depressive patients with Borna disease virus (BDV) infection: an open trial. (11254023)
2000
36
Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats. (10405111)
1999
37
Fine structure and morphogenesis of Borna disease virus. (9847384)
1999
38
Amantadine revisited: an open trial of amantadinesulfate treatment in chronically depressed patients with Borna disease virus infection. (10505484)
1999
39
Enhancement of Borna disease virus transcription in persistently infected cells by serum starvation. (10458109)
1999
40
Borna disease virus-induced neurological disorder in mice: infection of neonates results in immunopathology. (9557728)
1998
41
Two domains of the Borna disease virus p40 protein are required for interaction with the p23 protein. (9880009)
1998
42
Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders. (9111180)
1997
43
Neurobiology of Borna disease virus. (9179784)
1997
44
No Borna disease virus-specific RNA detected in blood from psychiatric patients in different regions of Germany. The Bornavirus Study Group. (9329518)
1997
45
Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome. (8549821)
1996
46
Human infections with Borna disease virus and potential pathogenic implications. (7789147)
1995
47
Presence of CD4+ and CD8+ T cells and expression of MHC class I and MHC class II antigen in horses with Borna disease virus-induced encephalitis. (8520721)
1995
48
Behavioral disturbances and pharmacology of Borna disease. (7789152)
1995
49
Borna disease virus (BDV), a nonsegmented RNA virus, replicates in the nuclei of infected cells where infectious BDV ribonucleoproteins are present. (8107202)
1994
50
Severity of neurological signs and degree of inflammatory lesions in the brains of rats with Borna disease correlate with the induction of nitric oxide synthase. (7690410)
1993

Genetic Variations for Borna Disease

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Expression for genes affiliated with Borna Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Borna Disease

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Pathways for genes affiliated with Borna Disease

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37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 12EMD Millipore, 29KEGG
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Pathways related to Borna Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8CD4, PRF1, CD8A
29.8PRF1, IFNG, CD8A
3
Hide members
9.8TBK1, HSPA8, IFNG
49.8CD4, PRF1, IFNG
5
Hide members
9.7CD4, CD8A, IFNG
6
Hide members
9.7HSPA8, HSPA5, PSMC1
79.7SERPINB6, IFNG, RAB5A
89.4HSPA8, TBK1, PSMC1, IFNG
9
Hide members
9.2IFNG, HSPA8, PSMC1, CD4, EXOSC3
10
Hide members
9.0PRF1, IFNG, IFNA1, PRDX6
11
Hide members
8.5TBK1, FURIN, KPNA2, IFNA1, IFNG, HSPA8
12
Hide members
8.5HSPA8, CD4, HSPA5, IFNG, IFNA1, PRF1
13
Hide members
8.0HSPA5, IFNG, KPNA2, PSMC1, TBK1, CD4

Compounds for genes affiliated with Borna Disease

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR
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Compounds related to Borna Disease according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1delta-12-pgj24410.3HSPA8, HSPA5
2leupeptin4410.1HSPA5, CD4, FURIN
3cyclopentenone4410.1HSPA8, HSPA5
4cycloferon449.9IFNG, IFNA1
5betaseron449.9IFNA1, IFNG
63-hydroxyanthranilic acid44 2410.8IFNA1, IFNG
7cycloheximide449.8CD4, IFNA1
8mezerein449.8IFNG, IFNA1
9dithiothreitol449.8FURIN, PRDX6, HSPA5
10lactacystin449.8HSPA5, IFNG, CD4
11kynurenine449.7IFNA1, IFNG
12poly(i-c)449.7TBK1, IFNA1, IFNG
13didanosine44 1110.6CD4, IFNA1
14neopterin449.6IFNG, IFNA1, CD4
152,5-oligoadenylate449.6PSMC1, IFNA1, IFNG
16superoxide44 2410.5HSPA5, HSPA8, PRDX6, PRF1, FURIN
17rantes449.4HSPA8, IFNG, IFNA1, CD4
18cholesterol44 28 11 2412.3HSPA5, HSPA8, PRF1, CD4, FURIN
19glatiramer acetate44 1110.3IFNA1, IFNG
20cysteine448.8HSPA5, HSPA8, IFNG, PRDX6, CD4, RAB5A
21zinc44 249.7HSPA5, HSPA8, KPNA2, RAB5A, SLC30A3, FURIN
22serine448.2HSPA5, HSPA8, IFNA1, PRDX6, PRF1, TBK1
23tyrosine447.7FURIN, HSPA5, HSPA8, IFNA1, S100A10, PRDX6

GO Terms for genes affiliated with Borna Disease

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16Gene Ontology
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Cellular components related to Borna Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell receptor complexGO:04210110.0CD8A, CD4
2melanosomeGO:0424709.4RAB5A, HSPA8, HSPA5

Biological processes related to Borna Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of membrane protein ectodomain proteolysisGO:05104410.0FURIN, IFNG
2defense response to virusGO:0516079.3CD8A, TBK1, PRF1, IFNG

Molecular functions related to Borna Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.0ALDOC, HSPA8, EXOSC3, KPNA2, PSMC1, PRDX6

Products for genes affiliated with Borna Disease

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  • Antibodies
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Sources for Borna Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet