MCID: BRN018
MIFTS: 51

Borna Disease malady

Summaries for Borna Disease

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection, which affects dopaminergic neurotransmission located in central nervous system, has material basis in borna disease virus, which is transmitted by contact with infected oronasal secretions. the infection has symptom mood disturbances, has symptom behaviour disturbances, has symptom cognitive disturbances, has symptom neurologic disturbances, and has symptom movement impairment.

MalaCards: Borna Disease, also known as enzootic encephalomyelitis, is related to encephalitis and multiple sclerosis, and has symptoms including movement impairment, neurologic disturbances and cognitive disturbances. An important gene associated with Borna Disease is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are TCR signaling in naive CD4+ T cells and Downstream signaling in naive CD8+ T cells. The compounds delta-12-pgj2 and leupeptin have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, brain and t cells, and related mouse phenotypes are integument and normal.

Wikipedia:63 Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease... more...

Aliases & Classifications for Borna Disease

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

borna disease 8 10 60
enzootic encephalomyelitis 8


External Ids:

Disease Ontology8 DOID:5154
SNOMED-CT56 76851008
MeSH34 D001890

Related Diseases for Borna Disease

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Borna Disease:



Diseases related to borna disease

Clinical Features for Borna Disease

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8Disease Ontology
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Symptoms:

8
  • movement impairment
  • neurologic disturbances
  • cognitive disturbances
  • behaviour disturbances
  • mood disturbances

Drugs & Therapeutics for Borna Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Borna Disease

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Anatomical Context for Borna Disease

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Borna Disease:

32
Brain, T cells, Cerebellum, Retina, Cortex, Pituitary, Prefrontal cortex, Testes, Thymus, Bone, Bone marrow

FMA organs/tissues related to Borna Disease:

14
Central nervous system

Animal Models for Borna Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Borna Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0HSPA5, S100A10, PRF1, TBK1, CD4
2MP:00028738.5FURIN, HSPA5, IFNG, PRDX6, PRF1, CD4
3MP:00036318.2IFNG, S100A10, PSMC1, PRF1, CD4, CD8A
4MP:00053767.6HSPA5, IFNG, S100A10, PSMC1, PRDX6, PRF1

Publications for Borna Disease

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Sources:
50PubMed
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Articles related to Borna Disease:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
Markers of Borna disease virus infection in cats with staggering disease. (22553310)
2012
2
A novel borna disease virus vector system that stably expresses foreign proteins from an intercistronic noncoding region. (21937656)
2011
3
Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for efficient viral spread. (20333534)
2010
4
Detection and analysis of Borna disease virus in Chinese patients with neurological disorders. (19364367)
2009
5
Second-site mutations in Borna disease virus overexpressing viral accessory protein X. (19420156)
2009
6
Borna disease virus RNA detected in Japanese macaques (Macaca fuscata). (17929110)
2008
7
RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives. (18623121)
2008
8
Cannabinoid rescue of striatal progenitor cells in chronic Borna disease viral encephalitis in rats. (18569459)
2008
9
Implications for a regulated replication of Borna disease virus in brains of experimentally infected Lewis rats. (18273698)
2008
10
Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection. (19014432)
2008
11
Adaptation of Borna disease virus to new host species attributed to altered regulation of viral polymerase activity. (17522214)
2007
12
Pathogenic potential of borna disease virus lacking the immunodominant CD8 T-cell epitope. (17686872)
2007
13
Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus. (16912310)
2006
14
Absence of Borna disease virus in the CNS of epilepsy patients. (16497548)
2006
15
Borna disease virus (BDV) infection in cats. A concise review based on current knowledge. (16841569)
2006
16
Vaccine-induced protection against Borna disease in wild-type and perforin-deficient mice. (15659759)
2005
17
Constitutive activation of the transcription factor NF-kappaB results in impaired borna disease virus replication. (15857990)
2005
18
CD8 T cells require gamma interferon to clear borna disease virus from the brain and prevent immune system-mediated neuronal damage. (16227271)
2005
19
Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder. (15668719)
2005
20
Expression of allograft inflammatory factor-1 and haeme oxygenase-1 in brains of rats infected with the neurotropic Borna disease virus. (16150122)
2005
21
2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread. (15047559)
2004
22
Overlap of interaction domains indicates a central role of the P protein in assembly and regulation of the Borna disease virus polymerase complex. (15509569)
2004
23
Exploring the cerebellum with a new tool: neonatal Borna disease virus (BDV) infection of the rat's brain. (12882236)
2003
24
Borna disease virus (BDV)-induced model of autism: application to vaccine safety test design. (12142944)
2002
25
Molecular biology of Borna disease virus and persistence. (11815302)
2002
26
Demonstration of continuously seropositive population against Borna disease virus in Misaki feral horses, a Japanese strain: a four-year follow-up study from 1998 to 2001. (12069079)
2002
27
Borna disease virus and neuropsychiatric disease--a reappraisal. (11435078)
2001
28
Borna disease virus-reactive antibodies and recent-onset psychiatric disorders. (11353599)
2001
29
Prevalence of circulating antibodies to p10, a non-structural protein of the Borna disease virus in cats with ataxia. (11789604)
2001
30
Borna disease virus nucleoprotein requires both nuclear localization and export activities for viral nucleocytoplasmic shuttling. (11238866)
2001
31
Identification and characterization of a new intron in Borna disease virus. (11172106)
2001
32
Expression and characterization of the Borna disease virus polymerase. (10756058)
2000
33
A role for Borna disease virus in schizophrenia? (10904242)
2000
34
Search for Borna disease virus in Danish fibromyalgia patients. (11132208)
2000
35
Authentic Borna disease virus transcripts are spliced less efficiently than cDNA-derived viral RNAs. (10900032)
2000
36
Isolation of Borna disease virus from human brain tissue. (10775596)
2000
37
Detection of borna disease virus-reactive antibodies from patients with psychiatric disorders and from horses by electrochemiluminescence immunoassay. (10473520)
1999
38
T cell ignorance in mice to Borna disease virus can be overcome by peripheral expression of the viral nucleoprotein. (10449769)
1999
39
Borna disease: a possible emerging zoonosis. (10596403)
1999
40
Humoral immunity in the central nervous system of Lewis rats infected with Borna disease virus. (9817440)
1998
41
Borna disease virus and neurospsychiatric disorders. (9284802)
1997
42
Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients. (9067654)
1997
43
Depression, Borna disease, and amantadine. (9093281)
1997
44
Amantadine and human Borna disease virus in vitro and in vivo in an infected patient with bipolar depression. (9111548)
1997
45
Neurological disease and encephalitis in cats experimentally infected with Borna disease virus. (9113204)
1997
46
Borna disease virus P-protein is phosphorylated by protein kinase Cepsilon and casein kinase II. (9268312)
1997
47
Prefrontal cortex dysfunction in Borna disease virus (BDV)--infected rats. (8886296)
1996
48
Borna disease virus: implications for human neuropsychiatric illness. (7728387)
1995
49
RNA splicing in Borna disease virus, a nonsegmented, negative-strand RNA virus. (8035500)
1994
50
Virus-like particles in MDCK cells persistently infected with Borna disease virus. (7985412)
1994

Genetic Variations for Borna Disease

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Expression for genes affiliated with Borna Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Borna Disease

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Pathways for genes affiliated with Borna Disease

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Sources:
37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 12EMD Millipore, 29KEGG
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Pathways related to Borna Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8CD8A, CD4, PRF1
29.8IFNG, PRF1, CD8A
3
Hide members
9.8TBK1, IFNG, HSPA8
49.8IFNG, PRF1, CD4
5
Hide members
9.7CD8A, CD4, IFNG
6
Hide members
9.7HSPA5, HSPA8, PSMC1
79.7SERPINB6, RAB5A, IFNG
89.4HSPA8, IFNG, PSMC1, TBK1
9
Hide members
9.2CD4, PSMC1, IFNG, EXOSC3, HSPA8
10
Hide members
9.0IFNG, IFNA1, PRDX6, PRF1
11
Hide members
8.5HSPA8, IFNG, IFNA1, KPNA2, TBK1, FURIN
12
Hide members
8.5CD8A, HSPA5, HSPA8, IFNG, IFNA1, PRF1
13
Hide members
8.0HSPA5, IFNG, IFNA1, KPNA2, PSMC1, TBK1

Compounds for genes affiliated with Borna Disease

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR
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Compounds related to Borna Disease according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1delta-12-pgj24410.3HSPA8, HSPA5
2leupeptin4410.1HSPA5, CD4, FURIN
3cyclopentenone4410.1HSPA8, HSPA5
4cycloferon449.9IFNG, IFNA1
5betaseron449.9IFNA1, IFNG
63-hydroxyanthranilic acid44 2410.8IFNA1, IFNG
7cycloheximide449.8CD4, IFNA1
8mezerein449.8IFNG, IFNA1
9dithiothreitol449.8FURIN, PRDX6, HSPA5
10lactacystin449.8HSPA5, IFNG, CD4
11kynurenine449.7IFNA1, IFNG
12poly(i-c)449.7TBK1, IFNA1, IFNG
13didanosine44 1110.6CD4, IFNA1
14neopterin449.6IFNG, IFNA1, CD4
152,5-oligoadenylate449.6PSMC1, IFNA1, IFNG
16superoxide44 2410.5HSPA5, HSPA8, PRDX6, PRF1, FURIN
17rantes449.4HSPA8, IFNG, IFNA1, CD4
18cholesterol44 28 11 2412.3HSPA5, HSPA8, PRF1, CD4, FURIN
19glatiramer acetate44 1110.3IFNA1, IFNG
20cysteine448.8HSPA5, HSPA8, IFNG, PRDX6, CD4, RAB5A
21zinc44 249.7HSPA5, HSPA8, KPNA2, RAB5A, SLC30A3, FURIN
22serine448.2HSPA5, HSPA8, IFNA1, PRDX6, PRF1, TBK1
23tyrosine447.7FURIN, HSPA5, HSPA8, IFNA1, S100A10, PRDX6

GO Terms for genes affiliated with Borna Disease

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16Gene Ontology
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Cellular components related to Borna Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell receptor complexGO:04210110.0CD8A, CD4
2melanosomeGO:0424709.4RAB5A, HSPA8, HSPA5

Biological processes related to Borna Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of membrane protein ectodomain proteolysisGO:05104410.0FURIN, IFNG
2defense response to virusGO:0516079.3CD8A, TBK1, PRF1, IFNG

Molecular functions related to Borna Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.0ALDOC, HSPA8, EXOSC3, KPNA2, PSMC1, PRDX6

Products for genes affiliated with Borna Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Borna Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet