MCID: BRN018
MIFTS: 50

Borna Disease malady

Infectious diseases, Neuronal diseases categories
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Summaries for Borna Disease

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection, which affects dopaminergic neurotransmission located in central nervous system, has material basis in borna disease virus, which is transmitted by contact with infected oronasal secretions. the infection has symptom mood disturbances, has symptom behaviour disturbances, has symptom cognitive disturbances, has symptom neurologic disturbances, and has symptom movement impairment.

MalaCards: Borna Disease, also known as enzootic encephalomyelitis, is related to multiple sclerosis and influenza, and has symptoms including movement impairment, neurologic disturbances and cognitive disturbances. An important gene associated with Borna Disease is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are IL12 signaling mediated by STAT4 and Downstream signaling in naive CD8+ T cells. The compounds delta-12-pgj2 and cyclopentenone have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, brain and t cells, and related mouse phenotype integument.

Wikipedia:65 Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease... more...

Aliases & Classifications for Borna Disease

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8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

borna disease 8 10 62
enzootic encephalomyelitis 8


External Ids:

Disease Ontology8 DOID:5154
SNOMED-CT58 76851008
MeSH35 D001890

Related Diseases for Borna Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Borna Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1multiple sclerosis30.2IFNG, IFNA1, HSPA8
2influenza29.9HSPA5, HSPA8, IFNA1, IFNG
3neuronitis10.6
4schizophrenia10.5
5encephalitis10.4
6chronic fatigue syndrome10.4
7mood disorder10.3
8neurologic diseases10.2
9autism spectrum disorder10.2
10brain injury10.2
11endophthalmitis10.1PRF1
12menieres disease10.1HSPA8
13aplastic anemia10.1IFNG
14thyroiditis10.0IFNA1
15plasmodium falciparum malaria10.0IFNG, HSPA8
16skin disease10.0IFNA1, PRF1
17lateral sclerosis10.0
18subacute sclerosing panencephalitis10.0
19obsessive-compulsive disorder10.0
20meningoencephalitis10.0
21viral encephalitis10.0
22rabies10.0
23amyotrophic lateral sclerosis10.0
24bipolar disorder10.0
25dementia10.0
26dystonia10.0
27encephalomyelitis10.0
28leukemia10.0
29obesity10.0
30oligodendroglioma10.0
31pneumonia10.0
32psychotic disorder10.0
33retinitis10.0
34stomatitis10.0
35t-cell leukemia10.0
36allergic encephalomyelitis10.0
37human t-cell leukemia virus type 110.0
38ataxia10.0
39fibromyalgia10.0
40herpes simplex10.0IFNA1, HSPA8
41relapsing-remitting multiple sclerosis10.0IFNG, IFNA1
42sezary's disease10.0IFNA1, IFNG
43factor vii deficiency10.0IFNA1, IFNG
44hepatitis b10.0IFNA1, IFNG
45tuberculosis10.0RAB5A, IFNG, PRF1, HSPA8
46cutaneous t cell lymphoma9.9IFNA1, IFNG
47colon cancer9.9IFNG, HSPA8, HSPA5
48hepatitis c9.9IFNG, IFNA1, HSPA5
49arthritis9.9IFNG, HSPA8, HSPA5
50kidney cancer9.9HSPA5, HSPA8, IFNA1, IFNG

Graphical network of the top 20 diseases related to Borna Disease:



Diseases related to borna disease

Symptoms for Borna Disease

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8Disease Ontology
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Symptoms:

8
  • movement impairment
  • neurologic disturbances
  • cognitive disturbances
  • behaviour disturbances
  • mood disturbances

Drugs & Therapeutics for Borna Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Borna Disease

Search NIH Clinical Center for Borna Disease

Genetic Tests for Borna Disease

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Anatomical Context for Borna Disease

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Borna Disease:

33
Brain, T cells, Cerebellum, Cortex, Retina, Prefrontal cortex, Pituitary, Thymus, Bone marrow, Testes, Bone

FMA organs/tissues related to Borna Disease:

14
Central nervous system

Animal Models for Borna Disease or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Borna Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.8S100A10, TBK1, IFNG, PRF1, HSPA5

Publications for Borna Disease

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Sources:
52PubMed
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Articles related to Borna Disease:

(show top 50)    (show all 490)
idTitleAuthorsYear
1
Upregulation of insulin-like growth factor binding protein 3 in astrocytes of transgenic mice that express Borna disease virus phosphoprotein. (21325425)
2011
2
Animal models of CNS viral disease: examples from borna disease virus models. (20204069)
2010
3
Identification of RNA instability elements in Borna disease virus. (19720240)
2009
4
Loss of connexin36 in rat hippocampus and cerebellar cortex in persistent Borna disease virus infection. (19038327)
2009
5
Borna disease virus P protein affects neural transmission through interactions with gamma-aminobutyric acid receptor-associated protein. (18815298)
2008
6
A rapid method for gene expression analysis of Borna disease virus in neurons and astrocytes using laser microdissection and real-time RT-PCR. (18054393)
2008
7
Borna disease virus infection in young children. (18771107)
2008
8
Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus. (16860408)
2007
9
Letter to the Editor refuting "Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations" by Ralf DA1rrwald, Jolanta Kolodziejek, Aemero Muluneh, Sibylle Herzog and Norbert Nowotny, Microbes and Infection 8 (2006) 917-929. (16616572)
2006
10
Prevalence of Borna disease virus RNA in populations at high or low risk for blood-borne infections. (15318870)
2004
11
Borna disease virus multiplication in mouse organotypic slice cultures is site-specifically inhibited by gamma interferon but not by interleukin-12. (14722276)
2004
12
Borna disease virus. (12707857)
2003
13
Two major histocompatibility complex class I-restricted epitopes of the Borna disease virus p10 protein identified by cytotoxic T lymphocytes induced by DNA-based immunization. (12719601)
2003
14
Borna disease virus glycoprotein is required for viral dissemination in neurons. (14581559)
2003
15
Borna disease virus induces acute fatal neurological disorders in neonatal gerbils without virus- and immune-mediated cell destructions. (12781712)
2003
16
Characterization of the acute immune response in the retina of Borna disease virus infected Lewis rats. (12667649)
2003
17
Identification of differentially expressed genes in brains of newborn Borna disease virus-infected rats in the absence of inflammation. (12536295)
2003
18
Borna disease in a dog in Japan. (12056780)
2002
19
Nosological study of Borna disease virus infection in race horses. (11750144)
2002
20
1-beta-D-arabinofuranosylcytosine inhibits borna disease virus replication and spread. (12021360)
2002
21
Borna disease virus (BDV)-induced model of autism: application to vaccine safety test design. (12142944)
2002
22
Molecular biology of Borna disease virus and persistence. (11815302)
2002
23
Neonatal Borna disease virus infection (BDV)-induced damage to the cerebellum is associated with sensorimotor deficits in developing Lewis rats. (11172881)
2001
24
Open reading frame III of borna disease virus encodes a nonglycosylated matrix protein. (11711600)
2001
25
Borna disease virus and psychiatry. (11246286)
2001
26
CD8(+) T lymphocytes mediate Borna disease virus-induced immunopathology independently of perforin. (11581414)
2001
27
Expression and characterization of the Borna disease virus polymerase. (10756058)
2000
28
Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology. (11189720)
2000
29
Antibodies to Borna disease virus in infected adult rats: an early appearance of anti-p10 antibody and recognition of novel virus-specific proteins in infected animal brain cells. (10945300)
2000
30
Borna disease in horses. (11219351)
2000
31
Borna disease in humans--speculations and controversies. (10071184)
1999
32
Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats. (10405111)
1999
33
Peripheral and intracerebral T cell immune response in cats naturally infected with Borna disease virus. (10438323)
1999
34
A serosurvey of Borna disease virus infection in wild rats by a capture ELISA. (10081747)
1999
35
High prevalence of Borna disease virus in domestic cats with neurological disorders in Japan. (10596800)
1999
36
Borna disease in Austrian horses. (9698629)
1998
37
The nucleolus is the site of Borna disease virus RNA transcription and replication. (9696879)
1998
38
Humoral immunity in the central nervous system of Lewis rats infected with Borna disease virus. (9817440)
1998
39
Microplate hybridization for Borna disease virus RNA in human peripheral blood mononuclear cells. (9144383)
1997
40
Borna disease virus and neurospsychiatric disorders. (9284802)
1997
41
Expression of tissue factor is increased in astrocytes within the central nervous system during persistent infection with borna disease virus. (8709198)
1996
42
Demonstration of borna disease virus RNA in peripheral blood mononuclear cells derived from domestic cats in Japan. (8748301)
1996
43
Detection of Borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence for high sequence conservation of human blood-derived BDV RNA. (8892892)
1996
44
Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome. (8549821)
1996
45
Varied prevalence of Borna disease virus infection in Arabic, thoroughbred and their cross-bred horses in Iran. (8896237)
1996
46
Detection of borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric patients. (8806563)
1996
47
Borna disease virus and schizophrenia. (7792340)
1995
48
RNA splicing contributes to the generation of mature mRNAs of Borna disease virus, a non-segmented negative strand RNA virus. (7831966)
1994
49
Borna disease virus-specific T cells protect against or cause immunopathological Borna disease. (7909324)
1994
50
Borna disease virus: immunoelectron microscopic characterization of cell-free virus and further information about the genome. (8084008)
1994

Variations for Borna Disease

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Expression for genes affiliated with Borna Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Borna Disease

Search GEO for disease gene expression data for Borna Disease.

Pathways for genes affiliated with Borna Disease

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Sources:
50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 30KEGG, 55Reactome
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Pathways related to Borna Disease according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IFNG, PRF1
2
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.9IFNG, PRF1
39.9PRF1, IFNG
49.9HSPA8, HSPA5
5
Show member pathways
9.9HSPA8, HSPA5
69.9HSPA8, HSPA5
7
Show member pathways
9.9HSPA5, HSPA8
8
Show member pathways
9.8IFNG, HSPA8
9
Show member pathways
Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway60
9.3HSPA5, HSPA8, PSMC1
109.3IFNG, IFNA1
119.3IFNG, IFNA1
12
Show member pathways
Alternative NF-kappaB pathway38
9.0PSMC1, TBK1, KPNA2
13
Show member pathways
Immune response CD16 signaling in NK cells60
9.0PRF1, IFNA1, IFNG
14
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.0IFNA1, IFNG, TBK1
159.0HSPA8, IFNG, PSMC1, TBK1
168.9IFNG, IFNA1, RAB5A
17
Show member pathways
8.7IFNA1, IFNG, KPNA2
18
Show member pathways
8.4HSPA8, HSPA5, PRF1, IFNA1, IFNG
19
Show member pathways
8.1KPNA2, TBK1, HSPA8, IFNA1, IFNG

Compounds for genes affiliated with Borna Disease

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45Novoseek, 24HMDB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB
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Compounds related to Borna Disease according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1delta-12-pgj24510.2HSPA8, HSPA5
2cyclopentenone4510.2HSPA5, HSPA8
3glucosamine45 24 1111.8IFNG, HSPA5
4cycloferon459.7IFNG, IFNA1
5betaseron459.7IFNA1, IFNG
63-hydroxyanthranilic acid45 2410.7IFNG, IFNA1
7mezerein459.7IFNG, IFNA1
8kynurenine459.7IFNA1, IFNG
9glatiramer acetate45 1110.6IFNG, IFNA1
10acyclovir45 1110.6IFNA1, IFNG
11il-12459.6IFNG, IFNA1
12indoleamine459.6IFNG, IFNA1
13imiquimod45 61 29 1112.6IFNA1, IFNG
14inosine monophosphate459.6TBK1, IFNA1
15polyinosinic-polycytidylic acid459.5IFNG, IFNA1
16mycophenolate mofetil45 51 1111.5IFNA1, IFNG
17poly(i-c)459.4IFNA1, IFNG, TBK1
18arsenite45 2410.4IFNA1, HSPA8, HSPA5
19ccl345 2910.3IFNG, IFNA1
20retinoid459.3IFNG, IFNA1, HSPA8
212,5-oligoadenylate459.2IFNG, IFNA1, PSMC1
22doxorubicin45 51 1111.1IFNA1, HSPA8, HSPA5
23rantes459.1TBK1, IFNG, IFNA1, HSPA8
24cycloheximide459.1HSPA5, PRF1, IFNA1, IFNG
25actinomycin d459.1HSPA5, IFNA1, IFNG
26zinc45 2410.1RAB5A, KPNA2, HSPA8, HSPA5
27cyclosporin a45 29 6111.1HSPA5, HSPA8, IFNA1, IFNG
28ribavirin45 51 1111.0IFNG, IFNA1
29cysteine459.0HSPA5, HSPA8, IFNG, RAB5A
30vegf458.9HSPA5, HSPA8, IFNA1, IFNG
31serine458.7HSPA5, HSPA8, PRF1, IFNA1, TBK1
32tyrosine458.2HSPA5, HSPA8, IFNA1, RAB5A, TBK1, S100A10

GO Terms for genes affiliated with Borna Disease

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16Gene Ontology
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Cellular components related to Borna Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1melanosomeGO:0424709.4RAB5A, HSPA8, HSPA5

Biological processes related to Borna Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:0516079.5TBK1, IFNG, PRF1
2ATP catabolic processGO:0062009.0HSPA5, HSPA8, PSMC1
3viral processGO:0160328.7TBK1, PSMC1, KPNA2, HSPA8

Molecular functions related to Borna Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.3S100A10, TBK1, RAB5A, PSMC1, KPNA2, PRF1

Products for genes affiliated with Borna Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Borna Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet