MCID: BRN018
MIFTS: 51

Borna Disease malady

Summaries for Borna Disease

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection, which affects dopaminergic neurotransmission located in central nervous system, has material basis in borna disease virus, which is transmitted by contact with infected oronasal secretions. the infection has symptom mood disturbances, has symptom behaviour disturbances, has symptom cognitive disturbances, has symptom neurologic disturbances, and has symptom movement impairment.

MalaCards: Borna Disease, also known as enzootic encephalomyelitis, is related to encephalitis and multiple sclerosis, and has symptoms including movement impairment, neurologic disturbances and cognitive disturbances. An important gene associated with Borna Disease is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are TCR signaling in naive CD4+ T cells and Downstream signaling in naive CD8+ T cells. The compounds delta-12-pgj2 and leupeptin have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, brain and t cells, and related mouse phenotypes are integument and normal.

Wikipedia:63 Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease... more...

Aliases & Classifications for Borna Disease

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

borna disease 8 10 60
enzootic encephalomyelitis 8


External Ids:

Disease Ontology8 DOID:5154
SNOMED-CT56 76851008
MeSH34 D001890

Related Diseases for Borna Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Borna Disease:



Diseases related to borna disease

Clinical Features for Borna Disease

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8Disease Ontology
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Symptoms:

8
  • movement impairment
  • neurologic disturbances
  • cognitive disturbances
  • behaviour disturbances
  • mood disturbances

Drugs & Therapeutics for Borna Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Borna Disease

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Anatomical Context for Borna Disease

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Borna Disease:

32
Brain, T cells, Cerebellum, Retina, Cortex, Pituitary, Prefrontal cortex, Testes, Thymus, Bone, Bone marrow

FMA organs/tissues related to Borna Disease:

14
Central nervous system

Animal Models for Borna Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Borna Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0HSPA5, S100A10, PRF1, TBK1, CD4
2MP:00028738.5FURIN, HSPA5, IFNG, PRDX6, PRF1, CD4
3MP:00036318.2IFNG, S100A10, PSMC1, PRF1, CD4, CD8A
4MP:00053767.6HSPA5, IFNG, S100A10, PSMC1, PRDX6, PRF1

Publications for Borna Disease

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50PubMed
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Articles related to Borna Disease:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
Analysis of borna disease virus trafficking in live infected cells by using a virus encoding a tetracysteine-tagged p protein. (24027309)
2013
2
The influence of Borna disease viral infection on dairy cow reproduction. (22123302)
2012
3
Borna disease virus infects human neural progenitor cells and impairs neurogenesis. (22190725)
2012
4
Borna disease virus infection in Italian children. A potential risk for the developing brain? (18771103)
2008
5
Neonatal Borna disease virus infection in rats is associated with increased extracellular levels of glutamate and neurodegeneration in the striatum. (17613708)
2007
6
Reverse-genetic approaches to the study of Borna disease virus. (16964271)
2006
7
Activation of microglia by borna disease virus infection: in vitro study. (17020949)
2006
8
Detection by radioligand assay of antibodies against Borna disease virus in patients with various psychiatric disorders. (15879032)
2005
9
Maturation of Borna disease virus glycoprotein. (16098520)
2005
10
Prevalence of Borna disease virus RNA in populations at high or low risk for blood-borne infections. (15318870)
2004
11
Regulation of the Borna disease virus polymerase complex by the viral nucleoprotein p38 isoform. Brief Report. (15221540)
2004
12
Borna disease virus infection, a human mental-health risk. (12857781)
2003
13
Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. II. Neurochemical alterations and responses to pharmacological treatments. (12106671)
2002
14
Borna disease virus accelerates inflammation and disease associated with transgenic expression of interleukin-12 in the central nervous system. (12414961)
2002
15
Characterization of an unusual importin alpha binding motif in the borna disease virus p10 protein that directs nuclear import. (11796712)
2002
16
Borna disease in a heifer in Japan. (11817858)
2002
17
Borna disease virus and psychiatry. (11246286)
2001
18
CD8(+) T lymphocytes mediate Borna disease virus-induced immunopathology independently of perforin. (11581414)
2001
19
Borna disease virus: a mystery as an emerging zoonotic pathogen. (11145828)
2001
20
Wild birds as a possible natural reservoir of Borna disease virus. (11561971)
2001
21
Borna disease virus infection in FIV-positive cats in Germany. (11517984)
2001
22
Epidemiology of Borna disease virus. (10950968)
2000
23
Synaptic pathology in Borna disease virus persistent infection. (10729116)
2000
24
Peripheral and intracerebral T cell immune response in cats naturally infected with Borna disease virus. (10438323)
1999
25
Borna disease in cats. (10097337)
1999
26
Inhibition of Borna disease virus multiplication by interferon: cell line differences in susceptibility. (10446654)
1999
27
Characterization of the major nuclear localization signal of the Borna disease virus phosphoprotein. (9934690)
1999
28
Borna disease in Austrian horses. (9698629)
1998
29
A single-tube RT-PCR method for the detection of Borna disease viral genomic RNA. (10093417)
1998
30
Lack of antiviral effect of amantadine in Borna disease virus infection. (9574902)
1998
31
In vivo treatment with anti-alpha4 integrin suppresses clinical and pathological evidence of Borna disease virus infection. (9628458)
1998
32
Borna disease virus (BDV), a (zoonotic?) worldwide pathogen. A review of the history of the disease and the virus infection with comprehensive bibliography. (9197210)
1997
33
Higher prevalence of Borna disease virus infection in blood donors living near thoroughbred horse farms. (9210045)
1997
34
Borna disease virus antibodies and the deficit syndrome of schizophrenia. (9075304)
1997
35
Molecular characterization of Borna disease virus from naturally infected animals and possible links to human disorders. (9413537)
1997
36
Clinical investigation of the relationship between Borna disease virus (BDV) infection and schizophrenia in 67 patients in Japan. (9421336)
1997
37
Detection of borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric patients. (8806563)
1996
38
Sequence variability of Borna disease virus open reading frame II found in human peripheral blood mononuclear cells. (8523585)
1996
39
A neural substrate of hyperactivity in borna disease: changes in brain dopamine receptors. (8806517)
1996
40
First isolates of infectious human Borna disease virus from patients with mood disorders. (9118344)
1996
41
In vitro cytotoxicity of sera of paralysed ostriches showing serological positivity for Borna disease virus. (8733182)
1996
42
Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells from healthy horses in Japan. (7491814)
1995
43
Borna disease virus genome transcribed and expressed in psychiatric patients. (7585039)
1995
44
Neutralizing antibodies in Borna disease virus-infected rats. (7815538)
1995
45
Hematologic consequences of Borna disease virus infection of rat bone marrow and thymus stromal cells. (7742537)
1995
46
Induction of protection against Borna disease by inoculation with high-dose-attenuated Borna disease virus. (7831798)
1995
47
Borna disease virus: immunoelectron microscopic characterization of cell-free virus and further information about the genome. (8084008)
1994
48
Early and persistent abnormalities in rats with neonatally acquired Borna disease virus infection. (8193931)
1994
49
Sequence conservation in field and experimental isolates of Borna disease virus. (8254777)
1994
50
Analysis of virus-specific RNA species and proteins in Freon-113 preparations of the Borna disease virus. (8283962)
1993

Genetic Variations for Borna Disease

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Expression for genes affiliated with Borna Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Borna Disease

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Pathways for genes affiliated with Borna Disease

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Sources:
37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 12EMD Millipore, 29KEGG
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Pathways related to Borna Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8CD8A, CD4, PRF1
29.8IFNG, PRF1, CD8A
3
Hide members
9.8TBK1, IFNG, HSPA8
49.8IFNG, PRF1, CD4
5
Hide members
9.7CD8A, CD4, IFNG
6
Hide members
9.7HSPA5, HSPA8, PSMC1
79.7SERPINB6, RAB5A, IFNG
89.4HSPA8, IFNG, PSMC1, TBK1
9
Hide members
9.2CD4, PSMC1, IFNG, EXOSC3, HSPA8
10
Hide members
9.0IFNG, IFNA1, PRDX6, PRF1
11
Hide members
8.5HSPA8, IFNG, IFNA1, KPNA2, TBK1, FURIN
12
Hide members
8.5CD8A, HSPA5, HSPA8, IFNG, IFNA1, PRF1
13
Hide members
8.0HSPA5, IFNG, IFNA1, KPNA2, PSMC1, TBK1

Compounds for genes affiliated with Borna Disease

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR
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Compounds related to Borna Disease according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1delta-12-pgj24410.3HSPA8, HSPA5
2leupeptin4410.1HSPA5, CD4, FURIN
3cyclopentenone4410.1HSPA8, HSPA5
4cycloferon449.9IFNG, IFNA1
5betaseron449.9IFNA1, IFNG
63-hydroxyanthranilic acid44 2410.8IFNA1, IFNG
7cycloheximide449.8CD4, IFNA1
8mezerein449.8IFNG, IFNA1
9dithiothreitol449.8FURIN, PRDX6, HSPA5
10lactacystin449.8HSPA5, IFNG, CD4
11kynurenine449.7IFNA1, IFNG
12poly(i-c)449.7TBK1, IFNA1, IFNG
13didanosine44 1110.6CD4, IFNA1
14neopterin449.6IFNG, IFNA1, CD4
152,5-oligoadenylate449.6PSMC1, IFNA1, IFNG
16superoxide44 2410.5HSPA5, HSPA8, PRDX6, PRF1, FURIN
17rantes449.4HSPA8, IFNG, IFNA1, CD4
18cholesterol44 28 11 2412.3HSPA5, HSPA8, PRF1, CD4, FURIN
19glatiramer acetate44 1110.3IFNA1, IFNG
20cysteine448.8HSPA5, HSPA8, IFNG, PRDX6, CD4, RAB5A
21zinc44 249.7HSPA5, HSPA8, KPNA2, RAB5A, SLC30A3, FURIN
22serine448.2HSPA5, HSPA8, IFNA1, PRDX6, PRF1, TBK1
23tyrosine447.7FURIN, HSPA5, HSPA8, IFNA1, S100A10, PRDX6

GO Terms for genes affiliated with Borna Disease

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16Gene Ontology
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Cellular components related to Borna Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell receptor complexGO:04210110.0CD8A, CD4
2melanosomeGO:0424709.4RAB5A, HSPA8, HSPA5

Biological processes related to Borna Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of membrane protein ectodomain proteolysisGO:05104410.0FURIN, IFNG
2defense response to virusGO:0516079.3CD8A, TBK1, PRF1, IFNG

Molecular functions related to Borna Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.0ALDOC, HSPA8, EXOSC3, KPNA2, PSMC1, PRDX6

Products for genes affiliated with Borna Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Borna Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet