Aliases & Classifications for Borna Disease

MalaCards integrated aliases for Borna Disease:

Name: Borna Disease 12 41 14 69
Enzootic Encephalomyelitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5154
MeSH 41 D001890
SNOMED-CT 64 76851008
UMLS 69 C0006023

Summaries for Borna Disease

Disease Ontology : 12 A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located in central nervous system, has material basis in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has symptom mood disturbances, has symptom behaviour disturbances, has symptom cognitive disturbances, has symptom neurologic disturbances, and has symptom movement impairment.

MalaCards based summary : Borna Disease, also known as enzootic encephalomyelitis, is related to neuronitis and schizophrenia, and has symptoms including mood disturbances, behaviour disturbances and cognitive disturbances. An important gene associated with Borna Disease is HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5), and among its related pathways/superpathways are Regulation of retinoblastoma protein and Notch Signaling Pathway (sino). Affiliated tissues include central nervous system, brain and t cells, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 72 Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease... more...

Related Diseases for Borna Disease

Graphical network of the top 20 diseases related to Borna Disease:



Diseases related to Borna Disease

Symptoms & Phenotypes for Borna Disease

Symptoms:

12
  • mood disturbances
  • behaviour disturbances
  • cognitive disturbances
  • neurologic disturbances
  • movement impairment

UMLS symptoms related to Borna Disease:


lameness, animal

GenomeRNAi Phenotypes related to Borna Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.02 TBK1 AXL
2 Decreased viability GR00221-A-2 10.02 HSPA5 TBK1 AXL CKM
3 Decreased viability GR00221-A-4 10.02 AXL
4 Decreased viability GR00301-A 10.02 HSPA5 TBK1 AXL
5 Decreased viability GR00342-S-1 10.02 TBK1
6 Decreased viability GR00342-S-2 10.02 TBK1
7 Increased viability after borna disease (rVSVI9G*/BDVG) virus infection GR00192-A 9.28 ABCB5 AXL CHMP1A CKM CPA1 CTBP1

Drugs & Therapeutics for Borna Disease

Search Clinical Trials , NIH Clinical Center for Borna Disease

Cochrane evidence based reviews: borna disease

Genetic Tests for Borna Disease

Anatomical Context for Borna Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Borna Disease:

18
Central Nervous System

MalaCards organs/tissues related to Borna Disease:

38
Brain, T Cells, Cerebellum, Cortex, Retina, Prefrontal Cortex, Pituitary

Publications for Borna Disease

Articles related to Borna Disease:

(show top 50) (show all 537)
# Title Authors Year
1
Different inhibitory effects on the proliferation and apoptosis of human and laboratory Borna disease virusa89infected human neuroblastoma SHa89SY5Y cells inA vitro. ( 29115502 )
2018
2
Application of antibodies against Borna disease virus phosphoprotein and nucleoprotein on paraffin sections. ( 29363723 )
2018
3
Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein. ( 28693611 )
2017
4
No molecular evidence of Borna disease virus among schizophrenia and bipolar disorder patients in Iran. ( 29214003 )
2017
5
Infections of horses and shrews with Bornaviruses in Upper Austria: a novel endemic area of Borna disease. ( 28634359 )
2017
6
Linkage between the leader sequence and leader RNA production in Borna disease virus-infected cells. ( 28715652 )
2017
7
Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production. ( 28446679 )
2017
8
Generation of a non-transmissive Borna disease virus vector lacking both matrix and glycoprotein genes. ( 28776750 )
2017
9
Detection of Antibodies against Borna Disease Virus Proteins in an Autistic Child and Her Mother. ( 28943599 )
2017
10
Detection of antibodies to Borna disease virus proteins in an autistic child and her mother. ( 27795475 )
2016
11
Neuronal retrograde transport of Borna disease virus occurs in signalling endosomes. ( 27902378 )
2016
12
Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. ( 27748825 )
2016
13
Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. ( 26700735 )
2016
14
Primary psychosis and Borna disease virus infection in Lithuania: a case control study. ( 27809822 )
2016
15
Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia. ( 28050187 )
2016
16
Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus. ( 27803166 )
2016
17
Sero-epidemiological analysis of vertical transmission relative risk of Borna disease virus infection in dairy herds. ( 27498995 )
2016
18
Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. ( 25810554 )
2015
19
Borna disease virus infection in cats: ABCD guidelines on prevention and management. ( 26101313 )
2015
20
Surface glycoprotein of Borna disease virus mediates virus spread from cell to cell. ( 26332529 )
2015
21
GC-MS-Based Metabonomic Profiling Displayed Differing Effects of Borna Disease Virus Natural Strain Hu-H1 and Laboratory Strain V Infection in Rat Cortical Neurons. ( 26287181 )
2015
22
Borna disease virus possesses an NF-A,B inhibitory sequence in the nucleoprotein gene. ( 25733193 )
2015
23
Borna disease virus infection impacts microRNAs associated with nervous system development, cell differentiation, proliferation and apoptosis in the hippocampi of neonatal rats. ( 26004383 )
2015
24
Neuropathogenesis of persistent infection with Borna disease virus. ( 26923969 )
2015
25
Discrepancy in the diagnosis of avian Borna disease virus infection of Psittaciformes by protein analysis of feather calami and enzyme-linked immunosorbent assay of plasma antibodies. ( 25701023 )
2015
26
Shedding of Infectious Borna Disease Virus-1 in Living Bicolored White-Toothed Shrews. ( 26313904 )
2015
27
Persistent human Borna disease virus infection modifies the acetylome of human oligodendroglia cells towards higher energy and transporter levels. ( 26210075 )
2015
28
X-linked RNA-binding motif protein (RBMX) is required for the maintenance of Borna disease virus nuclear viral factories. ( 26333388 )
2015
29
Health care professionals at risk of infection with Borna disease virus - evidence from a large hospital in China (Chongqing). ( 25888756 )
2015
30
Borna disease virus phosphoprotein impairs the developmental program controlling neurogenesis and reduces human GABAergic neurogenesis. ( 25923687 )
2015
31
Proteomics reveal energy metabolism and mitogen-activated protein kinase signal transduction perturbation in human Borna disease virus Hu-H1-infected oligodendroglial cells. ( 24637096 )
2014
32
Evidence for natural Borna disease virus infection in healthy domestic animals in three areas of western China. ( 24573218 )
2014
33
Borna disease virus infection in cats. ( 24480411 )
2014
34
Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran. ( 25186971 )
2014
35
Human borna disease virus infection impacts host proteome and histone lysine acetylation in human oligodendroglia cells. ( 25086498 )
2014
36
The bicolored white-toothed shrew Crocidura leucodon (HERMANN 1780) is an indigenous host of mammalian Borna disease virus. ( 24699636 )
2014
37
Subcellular localization of Borna disease virus proteins, P and X, after heat stress. BDV-infected OL cells were incubated at 40A^C for 12 hr. The cells were stained with anti-P (red) and anti-X (green) antibodies and counterstained with DAPI (blue). ( 25363744 )
2014
38
Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome. ( 25157155 )
2014
39
Heat stress is a potent stimulus for enhancing rescue efficiency of recombinant Borna disease virus. ( 25154584 )
2014
40
Real-time qPCR identifies suitable reference genes for Borna disease virus-infected rat cortical neurons. ( 25431926 )
2014
41
Glutamate and lipid metabolic perturbation in the hippocampi of asymptomatic borna disease virus-infected horses. ( 24956478 )
2014
42
A study on Borna disease virus infection in domestic cats in Japan. ( 24805904 )
2014
43
Nucleocytoplasmic shuttling of viral proteins in borna disease virus infection. ( 23965528 )
2013
44
Bicolored white-toothed shrews as reservoir for borna disease virus, Bavaria, Germany. ( 24274262 )
2013
45
Analysis of borna disease virus trafficking in live infected cells by using a virus encoding a tetracysteine-tagged p protein. ( 24027309 )
2013
46
Borna disease virus-induced neuronal degeneration dependent on host genetic background and prevented by soluble factors. ( 23319640 )
2013
47
Absence of a robust innate immune response in rat neurons facilitates persistent infection of Borna disease virus in neuronal tissue. ( 23793543 )
2013
48
Epidemiology and host spectrum of Borna disease virus infections. ( 23223618 )
2013
49
Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces. ( 24170181 )
2013
50
Borna disease virus nucleoprotein inhibits type I interferon induction through the interferon regulatory factor 7 pathway. ( 23939047 )
2013

Variations for Borna Disease

Expression for Borna Disease

Search GEO for disease gene expression data for Borna Disease.

Pathways for Borna Disease

Pathways related to Borna Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.7 CKM CTBP1
2 10.15 CTBP1 TBK1

GO Terms for Borna Disease

Cellular components related to Borna Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome membrane GO:0010008 8.8 CHMP1A FURIN TBK1

Biological processes related to Borna Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.26 AXL CTBP1 FDPS TBK1
2 animal organ regeneration GO:0031100 9.16 AXL FPGS
3 secretion by cell GO:0032940 8.62 AXL FURIN

Molecular functions related to Borna Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.13 CHMP1A CTBP1 HSPA5
2 ATP binding GO:0005524 9.1 ABCB5 AXL CKM FPGS HSPA5 TBK1

Sources for Borna Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
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47 NDF-RT
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51 Novoseek
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54 OMIM via Orphanet
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65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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