MCID: BRN018
MIFTS: 42

Borna Disease malady

Neuronal diseases category

Summaries for Borna Disease

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Disease Ontology:9 A viral infectious disease that results in infection, which affects dopaminergic neurotransmission located in central nervous system, has material basis in borna disease virus, which is transmitted by contact with infected oronasal secretions. the infection has symptom mood disturbances, has symptom behaviour disturbances, has symptom cognitive disturbances, has symptom neurologic disturbances, and has symptom movement impairment.

MalaCards based summary: Borna Disease, also known as enzootic encephalomyelitis, is related to influenza and neuronitis, and has symptoms including mood disturbances, behaviour disturbances and cognitive disturbances. An important gene associated with Borna Disease is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are IL12 signaling mediated by STAT4 and Downstream signaling in naive CD8+ T cells. The compounds delta-12-pgj2 and cyclopentenone have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, brain and t cells, and related mouse phenotype integument.

Wikipedia:63 Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease... more...

Aliases & Classifications for Borna Disease

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Borna Disease, Aliases & Descriptions:

Name: Borna Disease 9 11 60
 
Enzootic Encephalomyelitis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:5154
SNOMED-CT55 76851008
MeSH33 D001890

Related Diseases for Borna Disease

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Diseases related to Borna Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1influenza29.4IFNG, HSPA8, HSPA5, IFNA1
2neuronitis10.7
3schizophrenia10.5
4endophthalmitis10.5PRF1
5encephalitis10.5
6chronic fatigue syndrome10.4
7meniere's disease10.3HSPA8
8mood disorder10.3
9neurologic diseases10.3
10aplastic anemia10.2IFNG
11thyroiditis10.2IFNA1
12brain injury10.2
13autism spectrum disorder10.2
14plasmodium falciparum malaria10.0HSPA8, IFNG
15skin disease10.0IFNA1, PRF1
16obsessive-compulsive disorder10.0
17obesity10.0
18bipolar disorder10.0
19leukemia10.0
20lateral sclerosis10.0
21subacute sclerosing panencephalitis10.0
22meningoencephalitis10.0
23viral encephalitis10.0
24rabies10.0
25dementia10.0
26dystonia10.0
27oligodendroglioma10.0
28pneumonia10.0
29psychotic disorder10.0
30retinitis10.0
31stomatitis10.0
32t-cell leukemia10.0
33allergic encephalomyelitis10.0
34human t-cell leukemia virus type 110.0
35ataxia10.0
36fibromyalgia10.0
37herpes simplex10.0HSPA8, IFNA1
38relapsing-remitting multiple sclerosis10.0IFNA1, IFNG
39sezary's disease9.9IFNA1, IFNG
40factor vii deficiency9.9IFNA1, IFNG
41hepatitis b9.9IFNA1, IFNG
42tuberculosis9.8HSPA8, PRF1, IFNG, RAB5A
43cutaneous t cell lymphoma9.8IFNA1, IFNG
44colorectal cancer9.8HSPA8, IFNG, HSPA5
45hepatitis c9.7HSPA5, IFNA1, IFNG
46arthritis9.7IFNG, HSPA8, HSPA5
47multiple sclerosis, disease progression, modifier of9.6IFNA1, IFNG, HSPA8
48kidney cancer9.6HSPA5, HSPA8, IFNA1, IFNG
49viral infectious disease9.6IFNG, IFNA1, PSMC1, PRF1, TBK1
50melanoma9.4HSPA8, PRF1, HSPA5, IFNA1, IFNG

Graphical network of the top 20 diseases related to Borna Disease:



Diseases related to borna disease

Symptoms for Borna Disease

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Symptoms:

 9
  • mood disturbances
  • behaviour disturbances
  • cognitive disturbances
  • neurologic disturbances
  • movement impairment

Drugs & Therapeutics for Borna Disease

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Drug clinical trials:

Search ClinicalTrials for Borna Disease

Search NIH Clinical Center for Borna Disease

Genetic Tests for Borna Disease

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Anatomical Context for Borna Disease

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MalaCards organs/tissues related to Borna Disease:

31
Brain, T cells, Cerebellum, Cortex, Retina, Bone marrow, Bone, Thymus, Testes, Prefrontal cortex, Pituitary

FMA organs/tissues related to Borna Disease:

14
Central nervous system

Animal Models for Borna Disease or affiliated genes

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MGI Mouse Phenotypes related to Borna Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.8S100A10, TBK1, IFNG, PRF1, HSPA5

Publications for Borna Disease

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Articles related to Borna Disease:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Heat stress is a potent stimulus for enhancing rescue efficiency of recombinant Borna disease virus. (25154584)
2014
2
Proteomics reveal energy metabolism and mitogen-activated protein kinase signal transduction perturbation in human Borna disease virus Hu-H1-infected oligodendroglial cells. (24637096)
2014
3
Real-time qPCR identifies suitable reference genes for Borna disease virus-infected rat cortical neurons. (25431926)
2014
4
Subcellular localization of Borna disease virus proteins, P and X, after heat stress. BDV-infected OL cells were incubated at 40A^C for 12 hr. The cells were stained with anti-P (red) and anti-X (green) antibodies and counterstained with DAPI (blue). (25363744)
2014
5
A study on Borna disease virus infection in domestic cats in Japan. (24805904)
2014
6
Upregulation of insulin-like growth factor binding protein 3 in astrocytes of transgenic mice that express Borna disease virus phosphoprotein. (21325425)
2011
7
Identification of RNA instability elements in Borna disease virus. (19720240)
2009
8
Loss of connexin36 in rat hippocampus and cerebellar cortex in persistent Borna disease virus infection. (19038327)
2009
9
Borna disease virus P protein affects neural transmission through interactions with gamma-aminobutyric acid receptor-associated protein. (18815298)
2008
10
A rapid method for gene expression analysis of Borna disease virus in neurons and astrocytes using laser microdissection and real-time RT-PCR. (18054393)
2008
11
Borna disease virus infection in young children. (18771107)
2008
12
Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus. (16860408)
2007
13
Letter to the Editor refuting "Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations" by Ralf DA1rrwald, Jolanta Kolodziejek, Aemero Muluneh, Sibylle Herzog and Norbert Nowotny, Microbes and Infection 8 (2006) 917-929. (16616572)
2006
14
Prevalence of Borna disease virus RNA in populations at high or low risk for blood-borne infections. (15318870)
2004
15
Borna disease virus multiplication in mouse organotypic slice cultures is site-specifically inhibited by gamma interferon but not by interleukin-12. (14722276)
2004
16
Borna disease virus. (12707857)
2003
17
Two major histocompatibility complex class I-restricted epitopes of the Borna disease virus p10 protein identified by cytotoxic T lymphocytes induced by DNA-based immunization. (12719601)
2003
18
Borna disease virus glycoprotein is required for viral dissemination in neurons. (14581559)
2003
19
Borna disease virus induces acute fatal neurological disorders in neonatal gerbils without virus- and immune-mediated cell destructions. (12781712)
2003
20
Borna disease in a dog in Japan. (12056780)
2002
21
Nosological study of Borna disease virus infection in race horses. (11750144)
2002
22
1-beta-D-arabinofuranosylcytosine inhibits borna disease virus replication and spread. (12021360)
2002
23
Borna disease virus (BDV)-induced model of autism: application to vaccine safety test design. (12142944)
2002
24
Molecular biology of Borna disease virus and persistence. (11815302)
2002
25
Neonatal Borna disease virus infection (BDV)-induced damage to the cerebellum is associated with sensorimotor deficits in developing Lewis rats. (11172881)
2001
26
Open reading frame III of borna disease virus encodes a nonglycosylated matrix protein. (11711600)
2001
27
Borna disease virus and psychiatry. (11246286)
2001
28
Expression and characterization of the Borna disease virus polymerase. (10756058)
2000
29
Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology. (11189720)
2000
30
Antibodies to Borna disease virus in infected adult rats: an early appearance of anti-p10 antibody and recognition of novel virus-specific proteins in infected animal brain cells. (10945300)
2000
31
Borna disease in horses. (11219351)
2000
32
Borna disease in humans--speculations and controversies. (10071184)
1999
33
Persistent neonatal Borna disease virus (BDV) infection of the brain causes chronic emotional abnormalities in adult rats. (10405111)
1999
34
Peripheral and intracerebral T cell immune response in cats naturally infected with Borna disease virus. (10438323)
1999
35
A serosurvey of Borna disease virus infection in wild rats by a capture ELISA. (10081747)
1999
36
High prevalence of Borna disease virus in domestic cats with neurological disorders in Japan. (10596800)
1999
37
Borna disease in Austrian horses. (9698629)
1998
38
The nucleolus is the site of Borna disease virus RNA transcription and replication. (9696879)
1998
39
Humoral immunity in the central nervous system of Lewis rats infected with Borna disease virus. (9817440)
1998
40
Microplate hybridization for Borna disease virus RNA in human peripheral blood mononuclear cells. (9144383)
1997
41
Borna disease virus and neurospsychiatric disorders. (9284802)
1997
42
Expression of tissue factor is increased in astrocytes within the central nervous system during persistent infection with borna disease virus. (8709198)
1996
43
Demonstration of borna disease virus RNA in peripheral blood mononuclear cells derived from domestic cats in Japan. (8748301)
1996
44
Detection of Borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence for high sequence conservation of human blood-derived BDV RNA. (8892892)
1996
45
Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome. (8549821)
1996
46
Varied prevalence of Borna disease virus infection in Arabic, thoroughbred and their cross-bred horses in Iran. (8896237)
1996
47
Borna disease virus: implications for human neuropsychiatric illness. (7728387)
1995
48
RNA splicing contributes to the generation of mature mRNAs of Borna disease virus, a non-segmented negative strand RNA virus. (7831966)
1994
49
Borna disease virus-specific T cells protect against or cause immunopathological Borna disease. (7909324)
1994
50
Borna disease virus: immunoelectron microscopic characterization of cell-free virus and further information about the genome. (8084008)
1994

Variations for Borna Disease

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Expression for genes affiliated with Borna Disease

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Search GEO for disease gene expression data for Borna Disease.

Pathways for genes affiliated with Borna Disease

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Pathways related to Borna Disease according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IFNG, PRF1
2
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.9IFNG, PRF1
39.9IFNG, PRF1
49.9HSPA8, HSPA5
5
Show member pathways
9.9HSPA8, HSPA5
69.9HSPA8, HSPA5
7
Show member pathways
9.9HSPA5, HSPA8
8
Show member pathways
9.8IFNG, HSPA8
9
Show member pathways
Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway58
9.3PSMC1, HSPA8, HSPA5
109.3IFNA1, IFNG
119.3IFNA1, IFNG
12
Show member pathways
Alternative NF-kappaB pathway36
9.0TBK1, PSMC1, KPNA2
13
Show member pathways
Immune response CD16 signaling in NK cells58
9.0PRF1, IFNA1, IFNG
14
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.0TBK1, IFNG, IFNA1
159.0HSPA8, PSMC1, IFNG, TBK1
168.9IFNA1, IFNG, RAB5A
17
Show member pathways
8.7IFNG, IFNA1, KPNA2
18
Show member pathways
8.4IFNG, IFNA1, PRF1, HSPA8, HSPA5
19
Show member pathways
8.1HSPA8, KPNA2, IFNA1, IFNG, TBK1

Compounds for genes affiliated with Borna Disease

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Compounds related to Borna Disease according to GeneCards Suite gene sharing:

(show all 32)
idCompoundScoreTop Affiliating Genes
1delta-12-pgj24310.2HSPA8, HSPA5
2cyclopentenone4310.2HSPA5, HSPA8
3glucosamine43 24 1211.8IFNG, HSPA5
4cycloferon439.7IFNG, IFNA1
5betaseron439.7IFNA1, IFNG
63-hydroxyanthranilic acid43 2410.7IFNG, IFNA1
7mezerein439.7IFNG, IFNA1
8kynurenine439.7IFNA1, IFNG
9glatiramer acetate43 1210.6IFNG, IFNA1
10acyclovir43 1210.6IFNA1, IFNG
11il-12439.6IFNG, IFNA1
12indoleamine439.6IFNG, IFNA1
13imiquimod43 59 28 1212.6IFNA1, IFNG
14inosine monophosphate439.6TBK1, IFNA1
15polyinosinic-polycytidylic acid439.5IFNG, IFNA1
16mycophenolate mofetil43 49 1211.5IFNA1, IFNG
17poly(i-c)439.4IFNA1, IFNG, TBK1
18arsenite43 2410.4IFNA1, HSPA8, HSPA5
19ccl343 2810.3IFNG, IFNA1
20retinoid439.3IFNG, IFNA1, HSPA8
212,5-oligoadenylate439.2IFNG, IFNA1, PSMC1
22doxorubicin43 49 1211.1IFNA1, HSPA8, HSPA5
23rantes439.1TBK1, IFNG, IFNA1, HSPA8
24cycloheximide439.1HSPA5, PRF1, IFNA1, IFNG
25actinomycin d439.1HSPA5, IFNA1, IFNG
26zinc43 2410.1RAB5A, KPNA2, HSPA8, HSPA5
27cyclosporin a43 28 5911.1HSPA5, HSPA8, IFNA1, IFNG
28ribavirin43 49 1211.0IFNG, IFNA1
29cysteine439.0HSPA5, HSPA8, IFNG, RAB5A
30vegf438.9HSPA5, HSPA8, IFNA1, IFNG
31serine438.7HSPA5, HSPA8, PRF1, IFNA1, TBK1
32tyrosine438.2HSPA5, HSPA8, IFNA1, RAB5A, TBK1, S100A10

GO Terms for genes affiliated with Borna Disease

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Cellular components related to Borna Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1melanosomeGO:00424709.4RAB5A, HSPA8, HSPA5

Biological processes related to Borna Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:00516079.5TBK1, IFNG, PRF1
2ATP catabolic processGO:00062009.0HSPA5, HSPA8, PSMC1
3viral processGO:00160328.7TBK1, PSMC1, KPNA2, HSPA8

Molecular functions related to Borna Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055157.3S100A10, TBK1, RAB5A, PSMC1, KPNA2, PRF1

Products for genes affiliated with Borna Disease

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Sources for Borna Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet