MCID: BTR001
MIFTS: 46

Botryoid Rhabdomyosarcoma malady

Cancer diseases category

Summaries for Botryoid Rhabdomyosarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Sarcoma botryoides or botryoid sarcoma or botryoid rhabdomyosarcoma is a subtype of embryonal... more...

MalaCards: Botryoid Rhabdomyosarcoma, also known as sarcoma botryoides, is related to rhabdomyosarcoma and embryonal rhabdomyosarcoma. An important gene associated with Botryoid Rhabdomyosarcoma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and miRs in Muscle Cell Differentiation. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and liver, and related mouse phenotypes are no phenotypic analysis and muscle.

Aliases & Classifications for Botryoid Rhabdomyosarcoma

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Sources:
8Disease Ontology, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

botryoid rhabdomyosarcoma 8 60
sarcoma botryoides 8 42
botryoid sarcoma 8 60
botryoid-type embryonal rhabdomyosarcoma 8


External Ids:

Disease Ontology8 DOID:3255
NCIt39 C9150

Related Diseases for Botryoid Rhabdomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Botryoid Rhabdomyosarcoma family:

Adult Botryoid Rhabdomyosarcoma

Diseases related to Botryoid Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma31.3FOXO1, ACTC1, SLC22A18, PAX3, PAX7, DES
2embryonal rhabdomyosarcoma30.8PAX7, MYOG, ACTC1, PAX3, WT1, MYOD1
3sertoli-leydig cell tumor30.3WT1
4sertoli cell tumor30.3DES
5sarcoma30.1DES, WT1, FOXO1, ACTC1, MYOD1, PAX3
6nephroblastoma30.1WT1
7vulvar childhood botryoid-type embryonal rhabdomyosarcoma10.6
8adult botryoid rhabdomyosarcoma10.5
9vagina botryoid rhabdomyosarcoma10.4
10cervicitis10.3
11liver rhabdomyosarcoma10.3
12gallbladder rhabdomyosarcoma10.3
13adult vagina botryoid rhabdomyosarcoma10.3
14childhood vagina botryoid rhabdomyosarcoma10.3
15childhood botryoid rhabdomyosarcoma10.3
16bladder sarcoma10.2
17leydig cell tumor10.2
18vagina sarcoma10.2
19renal wilms' tumor10.1
20adult pleomorphic rhabdomyosarcoma10.1
21choledochal cyst10.1
22bile duct rhabdomyosarcoma10.1
23gallbladder sarcoma10.1
24laryngitis10.1
25pleomorphic rhabdomyosarcoma10.1
26primitive neuroectodermal tumor10.1
27prostate rhabdomyosarcoma10.1
28prostatitis10.1
29anus rhabdomyosarcoma10.1
30anus sarcoma10.1
31bile duct sarcoma10.1
32vaginitis10.1
33alveolar soft part sarcoma10.0MYOD1
34myoepithelioma10.0ACTC1
35fasciitis10.0ACTC1
36infantile myofibromatosis10.0DES
37chondrosarcoma10.0DES
38teratoma10.0ACTC1
39cryptorchidism10.0WT1
40hemangioma10.0ACTC1
41endometriosis10.0ACTC1
42metanephric adenoma10.0WT1
43adenomatoid tumor10.0WT1
44malignant mesenchymoma10.0MYOG, MYOD1
45endometrial carcinoma10.0KRT18
46benign mesothelioma10.0WT1
47uterine sarcoma10.0DES
48adenosarcoma10.0DES, ACTC1
49desmoid tumor10.0DES, ACTC1
50smooth muscle tumor10.0ACTC1, DES

Graphical network of the top 20 diseases related to Botryoid Rhabdomyosarcoma:



Diseases related to botryoid rhabdomyosarcoma

Clinical Features for Botryoid Rhabdomyosarcoma

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Drugs & Therapeutics for Botryoid Rhabdomyosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Botryoid Rhabdomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Botryoid Rhabdomyosarcoma

Search NIH Clinical Center for Botryoid Rhabdomyosarcoma

Search CenterWatch for Botryoid Rhabdomyosarcoma

Genetic Tests for Botryoid Rhabdomyosarcoma

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Anatomical Context for Botryoid Rhabdomyosarcoma

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32MalaCards
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MalaCards organs/tissues related to Botryoid Rhabdomyosarcoma:

32
Cervix, Uterus, Liver, Prostate

Animal Models for Botryoid Rhabdomyosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Botryoid Rhabdomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1PAX7, MYOD1, FOXO1, WT1, PAX3
2MP:00053698.0WT1, FOXO1, ACTC1, PAX3, PAX7, MYOD1
3MP:00053807.9PAX7, MYOG, FOXO1, WT1, KRT18, PAX3
4MP:00053857.9WT1, FOXO1, PAX3, MYOD1, ACTC1, DES
5MP:00053887.8PAX7, PAX3, MYOG, MYOD1, WT1
6MP:00028737.4PAX7, PAX3, MYOD1, FOXO1, MYOG, WT1
7MP:00053767.4ACTC1, PAX3, WT1, FOXO1, DES, MYOD1
8MP:00053787.0PAX3, WT1, PAX7, ACTC1, KRT18, MYOG
9MP:00107686.8PAX7, ACTC1, KRT18, MYOG, MYOD1, DES

Publications for Botryoid Rhabdomyosarcoma

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50PubMed
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Articles related to Botryoid Rhabdomyosarcoma:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
A botryoid rhabdomyosarcoma diagnosed as a choledochal cyst. (23832499)
2013
2
Embryonal rhabdomyosarcoma (botryoid type) of the uterine corpus and cervix in adult women: report of a case series and review of the literature. (23348207)
2013
3
Embryonal (botryoides) rhabdomyosarcoma of the uterus harboring a primitive neuroectodermal tumor component. (22653355)
2012
4
Massive diffuse intraperitoneal multicystic mass in an infant. Botryoid rhabdomyosarcoma (RMS). (22421724)
2012
5
Botryoid rhabdomyosarcoma of the uterine cervix. (22943732)
2012
6
Nutritional and Pharmacological Management during Chemotherapy in a Patient with Propionic Acidaemia and Rhabdomyosarcoma Botryoides. (23430942)
2012
7
Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters. (21278891)
2010
8
Late relapse of botryoid embryonal rhabdomyosarcoma of the vagina in prepubertal age. (19415026)
2009
9
Trisomy 8 as a sole aberration in embryonal rhabdomyosarcoma (sarcoma botryoides) of the vagina. (19963119)
2009
10
Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma. (19194282)
2009
11
A case of botryoid-type embryonal rhabdomyosarcoma. (19663848)
2009
12
Urinary bladder botryoid rhabdomyosarcoma with widespread metastases in an 8-month-old Labrador cross dog. (20169756)
2009
13
Primary renal botryoid rhabdomyosarcoma: diagnosis and outcome. (18082685)
2007
14
Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. (17630111)
2007
15
Botryoid rhabdomyosarcoma of the biliary tract in children: a unique case report. (17177904)
2006
16
Myogenic markers in the evaluation of embryonal botryoid rhabdomyosarcoma of the female genital tract. (16220232)
2005
17
Embryonal rhabdomyosarcoma (sarcoma botryoides) of the cervix presenting as a cervical polyp treated with fertility-sparing surgery and adjuvant chemotherapy. (15385139)
2004
18
Urinary Bladder Botryoid Rhabdomyosarcoma with Immature Cartilage in a 24-year-old Male Patient: A Case Report. (17657126)
2003
19
Botryoid-type of embryonal rhabdomyosarcoma of renal pelvis in an adult. A case report and review of the literature. (12673941)
2003
20
Botryoid rhabdomyosarcoma of mesentery--a case report. (15025305)
2003
21
Embryonal botryoid rhabdomyosarcoma of the bladder]. (12410104)
2002
22
Botryoid rhabdomyosarcoma of the bladder in an adult female. (17955586)
2002
23
Isochromosome (17)(q10) as the sole structural chromosomal rearrangement in a case of botryoid rhabdomyosarcoma. (11454423)
2001
24
Botryoid rhabdomyosarcoma of the nose: pitfalls of pathology. (11359096)
2001
25
Botryoid rhabdomyosarcoma of prostate--a case report. (12562002)
2001
26
Cytogenetic abnormalities in a case of botryoid rhabdomyosarcoma. (10742076)
2000
27
Botryoid rhabdomyosarcoma of the bladder. (9338741)
1997
28
Botryoid-type embryonal rhabdomyosarcoma of liver in a young cat. (9396144)
1997
29
Unique dermal and subcutaneous botryoid rhabdomyosarcoma associated with mature renal tissue: is this an extrarenal Wilms' tumor? (7971581)
1994
30
Botryoid rhabdomyosarcoma of the urinary bladder in a filly. (8373864)
1993
31
Computed tomography in botryoid rhabdomyosarcoma of urinary bladder. (2346927)
1990
32
Laryngeal botryoid rhabdomyosarcoma in an adult. Report of a case with electron microscopic study. (2780434)
1989
33
Vaginal botryoid embryonal rhabdomyosarcoma (sarcoma botryoides), A report of one case and review of the literature. (3048608)
1988
34
Embryonal botryoid rhabdomyosarcoma of the mitral valve. (3946244)
1986
35
Botryoid rhabdomyosarcoma of the nasopharynx. (6864097)
1983
36
Embryonal rhabdomyosarcoma (botryoid type) of the cervix: a case report and review. (7060985)
1982
37
Embryonal rhabdomyosarcoma of the middle ear presenting as sarcoma botryoides. Favorable outcome in a 12-year-old boy. (7085331)
1982
38
Botryoid rhabdomyosarcoma of the gallbladder in a child. (7055789)
1982
39
Botryoid rhabdomyosarcoma of the biliary tract. (7337157)
1981
40
Botryoid rhabdomyosarcoma of the uterus of a filly. (7400023)
1980
41
Embryonal rhabdomyosarcoma (sarcoma botryoides) of the common bile duct: a case report. (992649)
1976
42
Botryoid rhabdomyosarcoma of the urinary bladder and hypertrophic osteoarthropathy in a young dog. (4473190)
1974
43
An ultrastructural study of embryonal rhabdomyosarcoma (Sarcoma botryoides) of the bladder. (4349351)
1973
44
Nasal botryoid rhabdomyosarcoma. (5040563)
1972
45
Embryonal rhabdomyosarcoma (botryoid type) of the vagina. A clinicopathologic review. (4915719)
1970
46
Embryonal rhabdomyosarcoma (sarcoma botryoides) of the middle ear. (5502806)
1970
47
Embryonal rhabdomyosarcoma (sarcoma botryoides) of the biliary tree. Report of five cases and a review of the literature. (5796778)
1969
48
Botryoid rhabdomyosarcoma of the urinary bladder of a dog. (5693155)
1968
49
Sarcoma botryoides (embryonal rhabdomyosarcoma) of the anus. (13649117)
1959
50
Polypoid rhabdomyosarcoma of the bladder: sarcoma botryoides. (14369935)
1955

Genetic Variations for Botryoid Rhabdomyosarcoma

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Expression for genes affiliated with Botryoid Rhabdomyosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Botryoid Rhabdomyosarcoma

Search GEO for disease gene expression data for Botryoid Rhabdomyosarcoma.

Pathways for genes affiliated with Botryoid Rhabdomyosarcoma

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4Cell Signaling Technology, 37NCBI BioSystems Database, 53Reactome, 29KEGG
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Pathways related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5DES, KRT18, ACTC1
29.4MYOD1, PAX7
39.3MYOD1, FOXO1
4
Hide members
8.8MYOG, MYOD1, FOXO1
58.7PAX7, PAX3, FOXO1, WT1

Compounds for genes affiliated with Botryoid Rhabdomyosarcoma

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1orcein4410.1DES, ACTC1
2s 1004410.1ACTC1, DES
3reticulin4410.0ACTC1, DES
4mucicarmine449.9ACTC1, DES
5b 723449.9ACTC1, DES, WT1
6hematoxylin449.8DES, KRT18, ACTC1
7nash449.7ACTC1, KRT18
8formaldehyde44 2410.6DES, KRT18, ACTC1
9imatinib44 49 1111.5DES, WT1, ACTC1
10creatinine449.2WT1, MYOD1, KRT18, ACTC1
11glycogen44 2410.2ACTC1, KRT18, FOXO1, DES
12ribonucleic acid449.0MYOG, ACTC1, WT1
13bromodeoxyuridine449.0MYOD1, MYOG, KRT18, DES
1412-o-tetradecanoylphorbol 13-acetate449.0MYOD1, WT1, DES, MYOG
15progesterone44 59 28 11 2412.9ACTC1, WT1, FOXO1, KRT18, DES
16butyrate448.9WT1, MYOD1, KRT18, MYOG
17nitric oxide44 11 2410.9KRT18, MYOG, DES, WT1
18threonine448.6WT1, FOXO1, DES, MYOD1, KRT18
19oxygen44 249.5ACTC1, DES, MYOD1, KRT18, MYOG
20fatty acid448.5KRT18, MYOD1, MYOG, DES, FOXO1
21cysteine448.4WT1, PAX3, DES, MYOD1, MYOG
22paraffin448.4MYOD1, DES, WT1, KRT18, ACTC1, MYOG
23steroid448.4ACTC1, KRT18, MYOG, MYOD1, DES, WT1
24retinoic acid44 249.3KRT18, WT1, DES, ACTC1, MYOD1, MYOG
25glucose448.1MYOD1, DES, FOXO1, KRT18, ACTC1, MYOG
26oligonucleotide448.1WT1, MYOD1, MYOG, PAX3, PAX7, KRT18
27serine448.0MYOG, FOXO1, WT1, MYOD1, KRT18, DES
28testosterone44 59 11 2410.9MYOD1, WT1, FOXO1, DES, ACTC1, KRT18
29vegf447.9WT1, FOXO1, DES, MYOD1, MYOG, KRT18
30estrogen447.8WT1, ACTC1, MYOG, MYOD1, KRT18, FOXO1
31tyrosine447.4DES, MYOD1, WT1, PAX3, ACTC1, FOXO1

GO Terms for genes affiliated with Botryoid Rhabdomyosarcoma

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16Gene Ontology
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Biological processes related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1spinal cord association neuron differentiationGO:0215279.9PAX7, PAX3
2neuron fate commitmentGO:0486639.8PAX3, PAX7
3tissue developmentGO:0098889.8WT1, FOXO1
4muscle cell fate commitmentGO:0426939.6MYOD1, MYOG
5skeletal muscle fiber developmentGO:0487419.6MYOG, MYOD1
6cellular response to estradiol stimulusGO:0713929.6MYOG, MYOD1
7muscle filament slidingGO:0300499.6ACTC1, DES
8cellular response to starvationGO:0092679.4FOXO1, MYOD1
9positive regulation of muscle cell differentiationGO:0511499.3MYOG, MYOD1
10skeletal muscle tissue developmentGO:0075199.3MYOG, MYOD1
11muscle cell differentiationGO:0426929.2MYOD1, MYOG
12negative regulation of apoptotic processGO:0430669.0KRT18, WT1, FOXO1, PAX7
13apoptotic processGO:0069158.9FOXO1, KRT18, ACTC1, PAX3
14positive regulation of transcription from RNA polymerase II promoterGO:0459448.2MYOG, PAX7, PAX3, FOXO1, MYOD1

Molecular functions related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1E-box bindingGO:0708889.3MYOG, MYOD1
2chromatin DNA bindingGO:0314909.2MYOG, MYOD1
3core promoter bindingGO:0010479.0MYOG, MYOD1
4sequence-specific DNA bindingGO:0435658.7PAX3, WT1, PAX7, FOXO1

Products for genes affiliated with Botryoid Rhabdomyosarcoma

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Sources for Botryoid Rhabdomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet