MCID: BTR001
MIFTS: 47

Botryoid Rhabdomyosarcoma malady

Rare diseases, Cancer diseases categories
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Summaries for Botryoid Rhabdomyosarcoma

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Wikipedia:65 Sarcoma botryoides or botryoid sarcoma or botryoid rhabdomyosarcoma is a subtype of embryonal... more...

MalaCards based summary: Botryoid Rhabdomyosarcoma, also known as sarcoma botryoides, is related to rhabdomyosarcoma and embryonal rhabdomyosarcoma. An important gene associated with Botryoid Rhabdomyosarcoma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Striated Muscle Contraction. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and prostate, and related mouse phenotypes are cardiovascular system and normal.

Aliases & Classifications for Botryoid Rhabdomyosarcoma

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Botryoid Rhabdomyosarcoma, Aliases & Descriptions:

Name: Botryoid Rhabdomyosarcoma 8 62
Sarcoma Botryoides 8 42 62
 
Botryoid-Type Embryonal Rhabdomyosarcoma 8 62
Botryoid Sarcoma 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


External Ids:

Disease Ontology8 DOID:3255
NCIt39 C9150

Related Diseases for Botryoid Rhabdomyosarcoma

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Diseases in the Botryoid Rhabdomyosarcoma family:

Adult Botryoid Rhabdomyosarcoma

Diseases related to Botryoid Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1rhabdomyosarcoma30.6DES, MYOG, MYOD1, ACTC1, WT1
2embryonal rhabdomyosarcoma29.7DES, MYOD1, MYOG, ACTC1, WT1
3wilms tumor29.5WT1, ACTC1, MYOG, MYOD1, DES
4sarcoma29.5ACTC1, MYOG, WT1, DES, MYOD1
5alveolar soft part sarcoma10.5MYOD1
6fasciitis10.4ACTC1
7cervicitis10.4
8infantile myofibromatosis10.4DES
9adult vagina botryoid rhabdomyosarcoma10.4
10adult botryoid rhabdomyosarcoma10.4
11childhood botryoid rhabdomyosarcoma10.4
12childhood vagina botryoid rhabdomyosarcoma10.4
13vagina botryoid rhabdomyosarcoma10.4
14sertoli-leydig cell tumor10.3
15leydig cell tumor10.3
16metanephric adenoma10.3WT1
17malignant mesenchymoma10.3MYOD1, MYOG
18adenomatoid tumor10.3WT1
19neuroectodermal tumor10.2
20choledochal cyst10.2
21gallbladder sarcoma10.2
22laryngitis10.2
23pleomorphic rhabdomyosarcoma10.2
24prostatitis10.2
25myotonic dystrophy10.2MYOG, MYOD1
26myoma10.2MYOG, DES
27adenosarcoma10.2ACTC1, DES
28vulvar childhood botryoid-type embryonal rhabdomyosarcoma10.2
29bladder sarcoma10.2
30nephroblastoma10.2
31vagina sarcoma10.2
32vaginitis10.2
33epithelioid leiomyosarcoma10.2ACTC1, DES
34spindle cell carcinoma10.2ACTC1, DES
35myopathy congenital10.2MYOG, DES
36spindle cell sarcoma10.2DES, ACTC1
37angiosarcoma10.2ACTC1, KRT18
38desmoid tumor10.2DES, ACTC1
39cutaneous fibrous histiocytoma10.2DES, ACTC1
40fibrous histiocytoma10.1ACTC1, DES
41dermatofibrosarcoma protuberans10.1ACTC1, DES
42endometrial stromal sarcoma10.1DES, ACTC1
43duchenne muscular dystrophy10.1DES, MYOD1
44hemangiopericytoma10.1ACTC1, DES
45angiomyolipoma10.1ACTC1, DES
46fibroma10.1ACTC1, DES
47paraganglioma10.1ACTC1, DES
48uterine fibroid10.1MYOG, DES
49malignant mixed mullerian tumor10.1DES, ACTC1
50fibromatosis10.1DES, ACTC1

Graphical network of the top 20 diseases related to Botryoid Rhabdomyosarcoma:



Diseases related to botryoid rhabdomyosarcoma

Symptoms for Botryoid Rhabdomyosarcoma

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Drugs & Therapeutics for Botryoid Rhabdomyosarcoma

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Drug clinical trials:

Search ClinicalTrials for Botryoid Rhabdomyosarcoma

Search NIH Clinical Center for Botryoid Rhabdomyosarcoma

Genetic Tests for Botryoid Rhabdomyosarcoma

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Anatomical Context for Botryoid Rhabdomyosarcoma

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MalaCards organs/tissues related to Botryoid Rhabdomyosarcoma:

32
Uterus, Cervix, Prostate

Animal Models for Botryoid Rhabdomyosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Botryoid Rhabdomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.3WT1, ACTC1, MYOD1, DES
2MP:00028737.9MYOD1, MYOG, ACTC1, WT1
3MP:00053697.9WT1, ACTC1, MYOG, MYOD1, DES
4MP:00053767.6WT1, ACTC1, MYOG, MYOD1, DES
5MP:00053787.6MYOD1, MYOG, ACTC1, KRT18, WT1
6MP:00107687.2DES, MYOD1, MYOG, ACTC1, KRT18, WT1

Publications for Botryoid Rhabdomyosarcoma

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Articles related to Botryoid Rhabdomyosarcoma:

(show all 36)
idTitleAuthorsYear
1
A botryoid rhabdomyosarcoma diagnosed as a choledochal cyst. (23832499)
2013
2
Embryonal (botryoides) rhabdomyosarcoma of the uterus harboring a primitive neuroectodermal tumor component. (22653355)
2012
3
Massive diffuse intraperitoneal multicystic mass in an infant. Botryoid rhabdomyosarcoma (RMS). (22421724)
2012
4
Botryoid rhabdomyosarcoma of the uterine cervix. (22943732)
2012
5
Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma. (19194282)
2009
6
Urinary bladder botryoid rhabdomyosarcoma with widespread metastases in an 8-month-old Labrador cross dog. (20169756)
2009
7
Primary renal botryoid rhabdomyosarcoma: diagnosis and outcome. (18082685)
2007
8
Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. (17630111)
2007
9
Botryoid rhabdomyosarcoma of the biliary tract in children: a unique case report. (17177904)
2006
10
Myogenic markers in the evaluation of embryonal botryoid rhabdomyosarcoma of the female genital tract. (16220232)
2005
11
Myogenic markers in the evaluation of embryonal botryoid rhabdomyosarcoma of the female genital tract. (16010486)
2005
12
Botryoid rhabdomyosarcoma of vagina--two case reports. (15887839)
2004
13
Botryoid rhabdomyosarcoma of common bile duct. (15107524)
2004
14
Urinary Bladder Botryoid Rhabdomyosarcoma with Immature Cartilage in a 24-year-old Male Patient: A Case Report. (17657126)
2003
15
Botryoid rhabdomyosarcoma of mesentery--a case report. (15025305)
2003
16
Embryonal botryoid rhabdomyosarcoma of the bladder]. (12410104)
2002
17
Botryoid rhabdomyosarcoma of the bladder in an adult female. (17955586)
2002
18
Isochromosome (17)(q10) as the sole structural chromosomal rearrangement in a case of botryoid rhabdomyosarcoma. (11454423)
2001
19
Botryoid rhabdomyosarcoma of the nose: pitfalls of pathology. (11359096)
2001
20
Botryoid rhabdomyosarcoma of prostate--a case report. (12562002)
2001
21
Cytogenetic abnormalities in a case of botryoid rhabdomyosarcoma. (10742076)
2000
22
Botryoid rhabdomyosarcoma of the bladder. (9338741)
1997
23
Unique dermal and subcutaneous botryoid rhabdomyosarcoma associated with mature renal tissue: is this an extrarenal Wilms' tumor? (7971581)
1994
24
Cytogenetic study of botryoid rhabdomyosarcoma of the uterine cervix. (8438559)
1993
25
Botryoid rhabdomyosarcoma of the urinary bladder in a filly. (8373864)
1993
26
Computed tomography in botryoid rhabdomyosarcoma of urinary bladder. (2346927)
1990
27
Laryngeal botryoid rhabdomyosarcoma in an adult. Report of a case with electron microscopic study. (2780434)
1989
28
Embryonal botryoid rhabdomyosarcoma of the mitral valve. (3946244)
1986
29
Botryoid rhabdomyosarcoma of the nasopharynx. (6864097)
1983
30
Botryoid rhabdomyosarcoma of the gallbladder in a child. (7055789)
1982
31
Botryoid rhabdomyosarcoma in the urinary bladder of a dog. (7281468)
1981
32
Botryoid rhabdomyosarcoma of the biliary tract. (7337157)
1981
33
Botryoid rhabdomyosarcoma of the uterus of a filly. (7400023)
1980
34
Botryoid rhabdomyosarcoma of the urinary bladder and hypertrophic osteoarthropathy in a young dog. (4473190)
1974
35
Nasal botryoid rhabdomyosarcoma. (5040563)
1972
36
Botryoid rhabdomyosarcoma of the urinary bladder of a dog. (5693155)
1968

Variations for Botryoid Rhabdomyosarcoma

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Expression for genes affiliated with Botryoid Rhabdomyosarcoma

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Expression patterns in normal tissues for genes affiliated with Botryoid Rhabdomyosarcoma

Search GEO for disease gene expression data for Botryoid Rhabdomyosarcoma.

Pathways for genes affiliated with Botryoid Rhabdomyosarcoma

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Pathways related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.6ACTC1, DES
2
Show member pathways
9.6DES, ACTC1
3
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection37
9.4KRT18, ACTC1
4
Show member pathways
9.1MYOG, MYOD1
5
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis60
9.1MYOG, MYOD1
69.1MYOG, MYOD1
79.0KRT18, ACTC1, DES

Compounds for genes affiliated with Botryoid Rhabdomyosarcoma

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Compounds related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1orcein4410.0ACTC1, DES
2s 1004410.0ACTC1, DES
3reticulin4410.0ACTC1, DES
4mucicarmine4410.0ACTC1, DES
5procollagen449.9DES, ACTC1
6nash449.8ACTC1, KRT18
7biotin44 24 1111.8ACTC1, DES
8tetracycline44 1110.6WT1, KRT18
9b 723449.5DES, ACTC1, WT1
10imatinib44 50 1111.5WT1, ACTC1, DES
11p002449.5DES, KRT18
12hematoxylin449.4KRT18, ACTC1, DES
13azathioprine44 2 50 1112.4DES, MYOD1
14formaldehyde44 2410.4DES, ACTC1, KRT18
15ribonucleic acid449.4WT1, ACTC1, MYOG
16glycogen44 2410.3DES, ACTC1, KRT18
17gold449.3DES, KRT18
18iron44 2410.3KRT18, ACTC1, DES
19lactacystin449.3MYOD1, KRT18
20doxorubicin44 50 1111.2WT1, KRT18, DES
21thymidine44 2410.1WT1, KRT18, DES
22forskolin44 50 1111.1MYOG, KRT18, WT1
23mg 13244 6110.0KRT18, MYOD1
24acetylcholine44 50 28 24 1113.0MYOG, MYOD1, DES
25lysine449.0DES, MYOD1, WT1
26actinomycin d448.9KRT18, MYOD1, DES
27progesterone44 28 61 24 1112.9DES, ACTC1, KRT18, WT1
28arginine448.8DES, MYOD1, WT1
29citrate448.7KRT18, MYOD1
30nitric oxide44 24 1110.7DES, MYOG, KRT18, WT1
31zinc44 249.6WT1, KRT18, MYOD1
3212-o-tetradecanoylphorbol 13-acetate448.6WT1, MYOG, MYOD1, DES
33cysteine448.5DES, MYOD1, MYOG, WT1
34bromodeoxyuridine448.5DES, MYOD1, MYOG, KRT18
35fatty acid448.5DES, MYOD1, MYOG, KRT18
36threonine448.4DES, MYOD1, KRT18, WT1
37butyrate448.4MYOD1, MYOG, KRT18, WT1
38oligonucleotide448.4WT1, KRT18, MYOG, MYOD1
39calcium44 50 24 1111.3ACTC1, MYOG, MYOD1, DES
40oxygen44 249.1DES, MYOD1, MYOG, ACTC1, KRT18
41glucose448.1DES, MYOD1, MYOG, ACTC1, KRT18
42serine447.9DES, MYOD1, MYOG, KRT18, WT1
43paraffin447.6WT1, KRT18, ACTC1, MYOG, MYOD1, DES
44creatinine447.6DES, MYOD1, MYOG, ACTC1, KRT18, WT1
45testosterone44 61 24 1110.6DES, MYOD1, MYOG, ACTC1, KRT18, WT1
46steroid447.6DES, MYOD1, MYOG, ACTC1, KRT18, WT1
47vegf447.6DES, MYOD1, MYOG, ACTC1, KRT18, WT1
48estrogen447.6DES, MYOD1, MYOG, ACTC1, KRT18, WT1
49retinoic acid44 248.6DES, MYOD1, MYOG, ACTC1, KRT18, WT1
50tyrosine447.6WT1, KRT18, ACTC1, MYOG, MYOD1, DES

GO Terms for genes affiliated with Botryoid Rhabdomyosarcoma

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Cellular components related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.4KRT18, DES

Biological processes related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.6DES, ACTC1
2muscle cell fate commitmentGO:0426939.3MYOG, MYOD1
3skeletal muscle fiber developmentGO:0487419.3MYOG, MYOD1
4cellular response to estradiol stimulusGO:0713929.3MYOD1, MYOG
5positive regulation of muscle cell differentiationGO:0511499.2MYOG, MYOD1
6muscle cell differentiationGO:0426929.2MYOG, MYOD1
7skeletal muscle tissue developmentGO:0075199.0MYOG, MYOD1
8negative regulation of apoptotic processGO:0430668.6WT1, KRT18, ACTC1
9positive regulation of transcription from RNA polymerase II promoterGO:0459448.6WT1, MYOG, MYOD1

Molecular functions related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1core promoter bindingGO:0010479.1MYOG, MYOD1
2chromatin DNA bindingGO:0314909.0MYOG, MYOD1
3E-box bindingGO:0708888.8MYOG, MYOD1

Products for genes affiliated with Botryoid Rhabdomyosarcoma

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  • Antibodies
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Sources for Botryoid Rhabdomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet