MCID: BTR001
MIFTS: 44

Botryoid Rhabdomyosarcoma malady

Cancer category

Summaries for Botryoid Rhabdomyosarcoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Sarcoma botryoides or botryoid sarcoma or botryoid rhabdomyosarcoma is a subtype of embryonal... more...

MalaCards: Botryoid Rhabdomyosarcoma, also known as sarcoma botryoides, is related to uterine sarcoma and sertoli-leydig cell tumor. An important gene associated with Botryoid Rhabdomyosarcoma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and miRs in Muscle Cell Differentiation. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include liver, uterus and prostate, and related mouse phenotypes are no phenotypic analysis and muscle.

Aliases & Classifications for Botryoid Rhabdomyosarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 57SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

botryoid rhabdomyosarcoma 8 61
sarcoma botryoides 8 43
botryoid sarcoma 8 61
botryoid-type embryonal rhabdomyosarcoma 8


External Ids:

Disease Ontology8 DOID:3255
NCIt40 C9150

Related Diseases for Botryoid Rhabdomyosarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Botryoid Rhabdomyosarcoma family:

adult botryoid rhabdomyosarcoma

Diseases related to Botryoid Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1uterine sarcoma30.5DES
2sertoli-leydig cell tumor30.4WT1
3sertoli cell tumor30.4DES
4wilms tumor30.2MYOD1, MYOG, SLC22A18, ACTC1, WT1, DES
5vulvar childhood botryoid-type embryonal rhabdomyosarcoma10.7
6embryonal sarcoma10.7
7adult botryoid rhabdomyosarcoma10.5
8vagina botryoid rhabdomyosarcoma10.4
9vagina sarcoma10.4
10liver rhabdomyosarcoma10.4
11gallbladder rhabdomyosarcoma10.3
12adult vagina botryoid rhabdomyosarcoma10.3
13childhood vagina botryoid rhabdomyosarcoma10.3
14childhood botryoid rhabdomyosarcoma10.3
15bladder sarcoma10.3
16renal wilms' tumor10.2
17adult pleomorphic rhabdomyosarcoma10.2
18choledochal cyst10.2
19bile duct rhabdomyosarcoma10.2
20anus rhabdomyosarcoma10.1
21anus sarcoma10.1
22bile duct sarcoma10.1
23alveolar soft part sarcoma10.0MYOD1
24myoepithelioma10.0ACTC1
25fasciitis10.0ACTC1
26nephroblastoma10.0WT1
27infantile myofibromatosis10.0DES
28chondrosarcoma10.0DES
29teratoma10.0ACTC1
30cryptorchidism10.0WT1
31hemangioma10.0ACTC1
32endometriosis10.0ACTC1
33metanephric adenoma10.0WT1
34adenomatoid tumor10.0WT1
35malignant mesenchymoma10.0MYOG, MYOD1
36endometrial carcinoma10.0KRT18
37benign mesothelioma10.0WT1
38adenosarcoma10.0DES, ACTC1
39desmoid tumor10.0DES, ACTC1
40smooth muscle tumor10.0ACTC1, DES
41epithelioid leiomyosarcoma10.0DES, ACTC1
42angiomyolipoma10.0ACTC1, DES
43spindle cell carcinoma10.0DES, ACTC1
44spindle cell sarcoma10.0DES, ACTC1
45cutaneous fibrous histiocytoma10.0ACTC1, DES
46fibrous histiocytoma10.0DES, ACTC1
47malignant mesothelioma10.0DES, WT1
48desmoplastic small round cell tumor10.0WT1, DES
49myopathy congenital10.0DES, MYOG
50endometrial stromal sarcoma10.0DES, ACTC1

Graphical network of the top 20 diseases related to Botryoid Rhabdomyosarcoma:



Diseases related to botryoid rhabdomyosarcoma

Clinical Features for Botryoid Rhabdomyosarcoma

Drugs & Therapeutics for Botryoid Rhabdomyosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Botryoid Rhabdomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Botryoid Rhabdomyosarcoma

Search NIH Clinical Center for Botryoid Rhabdomyosarcoma

Search CenterWatch for Botryoid Rhabdomyosarcoma

Genetic Tests for Botryoid Rhabdomyosarcoma

Anatomical Context for Botryoid Rhabdomyosarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Botryoid Rhabdomyosarcoma:

33
Liver, Uterus, Prostate, Cervix, Uterus corpus

Animal Models for Botryoid Rhabdomyosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Botryoid Rhabdomyosarcoma

Sources:
51PubMed
See all sources

Articles related to Botryoid Rhabdomyosarcoma:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
A botryoid rhabdomyosarcoma diagnosed as a choledochal cyst. (23832499)
2013
2
Embryonal rhabdomyosarcoma (botryoid type) of the uterine corpus and cervix in adult women: report of a case series and review of the literature. (23348207)
2013
3
Embryonal (botryoides) rhabdomyosarcoma of the uterus harboring a primitive neuroectodermal tumor component. (22653355)
2012
4
Botryoid rhabdomyosarcoma of the uterine cervix. (22943732)
2012
5
Primary "botryoid" embryonal rhabdomyosarcoma in mesentery. (21469433)
2011
6
Late relapse of botryoid embryonal rhabdomyosarcoma of the vagina in prepubertal age. (19415026)
2009
7
Trisomy 8 as a sole aberration in embryonal rhabdomyosarcoma (sarcoma botryoides) of the vagina. (19963119)
2009
8
Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma. (19194282)
2009
9
A case of botryoid-type embryonal rhabdomyosarcoma. (19663848)
2009
10
Urinary bladder botryoid rhabdomyosarcoma with widespread metastases in an 8-month-old Labrador cross dog. (20169756)
2009
11
Late relapse of embryonal rhabdomyosarcoma, botryoid variant, of the vagina. (18253956)
2008
12
Primary renal botryoid rhabdomyosarcoma: diagnosis and outcome. (18082685)
2007
13
Botryoid-type pleomorphic rhabdomyosarcoma of the renal pelvis in an adult. A rare case report and review of the literature. (16825824)
2006
14
Myogenic markers in the evaluation of embryonal botryoid rhabdomyosarcoma of the female genital tract. (16010486)
2005
15
Botryoid rhabdomyosarcoma of vagina--two case reports. (15887839)
2004
16
Embryonal rhabdomyosarcoma (sarcoma botryoides) of the cervix presenting as a cervical polyp treated with fertility-sparing surgery and adjuvant chemotherapy. (15385139)
2004
17
Botryoid rhabdomyosarcoma of common bile duct. (15107524)
2004
18
Urinary Bladder Botryoid Rhabdomyosarcoma with Immature Cartilage in a 24-year-old Male Patient: A Case Report. (17657126)
2003
19
Botryoid-type of embryonal rhabdomyosarcoma of renal pelvis in an adult. A case report and review of the literature. (12673941)
2003
20
Botryoid rhabdomyosarcoma of mesentery--a case report. (15025305)
2003
21
Botryoid rhabdomyosarcoma of the bladder in an adult female. (17955586)
2002
22
Isochromosome (17)(q10) as the sole structural chromosomal rearrangement in a case of botryoid rhabdomyosarcoma. (11454423)
2001
23
Botryoid rhabdomyosarcoma of the nose: pitfalls of pathology. (11359096)
2001
24
Embryonal "Botryoid" rhabdomyosarcoma of the larynx: a clinicopathologic and immunohistochemical study of two cases. (10594285)
1999
25
Botryoid rhabdomyosarcoma of the bladder. (9338741)
1997
26
Botryoid-type embryonal rhabdomyosarcoma of liver in a young cat. (9396144)
1997
27
Botryoid embryonal rhabdomyosarcoma of Stensen's duct. (8820189)
1996
28
Unique dermal and subcutaneous botryoid rhabdomyosarcoma associated with mature renal tissue: is this an extrarenal Wilms' tumor? (7971581)
1994
29
Two different manifestations of botryoid sarcoma (embryonal rhabdomyosarcoma) of the biliary tree. (8193517)
1994
30
Cytogenetic study of botryoid rhabdomyosarcoma of the uterine cervix. (8438559)
1993
31
Botryoid rhabdomyosarcoma of the urinary bladder in a filly. (8373864)
1993
32
Laryngeal botryoid rhabdomyosarcoma in an adult. Report of a case with electron microscopic study. (2780434)
1989
33
Vaginal botryoid embryonal rhabdomyosarcoma (sarcoma botryoides), A report of one case and review of the literature. (3048608)
1988
34
Embryonal botryoid rhabdomyosarcoma of the mitral valve. (3946244)
1986
35
Sarcoma botryoides (embryonal rhabdomyosarcoma). (6683296)
1983
36
Botryoid rhabdomyosarcoma of the nasopharynx. (6864097)
1983
37
Embryonal rhabdomyosarcoma (botryoid type) of the cervix: a case report and review. (7060985)
1982
38
Embryonal rhabdomyosarcoma of the middle ear presenting as sarcoma botryoides. Favorable outcome in a 12-year-old boy. (7085331)
1982
39
Botryoid rhabdomyosarcoma in the urinary bladder of a dog. (7281468)
1981
40
Botryoid rhabdomyosarcoma of the biliary tract. (7337157)
1981
41
Embryonal rhabdomyosarcoma (sarcoma botryoides) of the common bile duct: a case report. (992649)
1976
42
Botryoid rhabdomyosarcoma of the urinary bladder and hypertrophic osteoarthropathy in a young dog. (4473190)
1974
43
An ultrastructural study of embryonal rhabdomyosarcoma (Sarcoma botryoides) of the bladder. (4349351)
1973
44
Nasal botryoid rhabdomyosarcoma. (5040563)
1972
45
Embryonal rhabdomyosarcoma (botryoid type) of the vagina. A clinicopathologic review. (4915719)
1970
46
Embryonal rhabdomyosarcoma (sarcoma botryoides) of the middle ear. (5502806)
1970
47
Embryonal rhabdomyosarcoma (sarcoma botryoides) of the biliary tree. Report of five cases and a review of the literature. (5796778)
1969
48
Botryoid rhabdomyosarcoma of the urinary bladder of a dog. (5693155)
1968
49
Sarcoma botryoides (embryonal rhabdomyosarcoma) of the anus. (13649117)
1959
50
Polypoid rhabdomyosarcoma of the bladder: sarcoma botryoides. (14369935)
1955

Genetic Variations for Botryoid Rhabdomyosarcoma

Expression for genes affiliated with Botryoid Rhabdomyosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Botryoid Rhabdomyosarcoma

Search GEO for disease gene expression data for Botryoid Rhabdomyosarcoma.

Pathways for genes affiliated with Botryoid Rhabdomyosarcoma

Sources:
4Cell Signaling Technology, 38NCBI BioSystems Database, 54Reactome, 30KEGG
See all sources

Pathways related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ACTC1, KRT18, DES
29.4PAX7, MYOD1
39.3FOXO1, MYOD1
4
Hide members
8.8MYOG, MYOD1, FOXO1
58.7PAX7, PAX3, FOXO1, WT1

Compounds for genes affiliated with Botryoid Rhabdomyosarcoma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1orcein4510.1ACTC1, DES
2s 1004510.1ACTC1, DES
3reticulin4510.0ACTC1, DES
4mucicarmine459.9ACTC1, DES
5b 723459.9WT1, DES, ACTC1
6hematoxylin459.8DES, KRT18, ACTC1
7nash459.7KRT18, ACTC1
8formaldehyde45 2410.6DES, KRT18, ACTC1
9imatinib45 50 1111.5ACTC1, DES, WT1
10creatinine459.2WT1, MYOD1, KRT18, ACTC1
11glycogen45 2410.2ACTC1, KRT18, DES, FOXO1
12ribonucleic acid459.0ACTC1, MYOG, WT1
13bromodeoxyuridine459.0DES, MYOD1, MYOG, KRT18
1412-o-tetradecanoylphorbol 13-acetate459.0WT1, DES, MYOD1, MYOG
15progesterone45 60 29 11 2412.9WT1, FOXO1, DES, KRT18, ACTC1
16butyrate458.9KRT18, MYOG, MYOD1, WT1
17nitric oxide45 11 2410.9KRT18, MYOG, DES, WT1
18threonine458.6WT1, FOXO1, DES, MYOD1, KRT18
19oxygen45 249.5DES, MYOD1, MYOG, KRT18, ACTC1
20fatty acid458.5KRT18, MYOG, MYOD1, DES, FOXO1
21cysteine458.4WT1, DES, MYOD1, MYOG, PAX3
22paraffin458.4WT1, DES, MYOD1, MYOG, KRT18, ACTC1
23steroid458.4WT1, DES, MYOD1, MYOG, KRT18, ACTC1
24retinoic acid45 249.3WT1, DES, MYOD1, MYOG, KRT18, ACTC1
25glucose458.1FOXO1, DES, MYOD1, MYOG, KRT18, ACTC1
26oligonucleotide458.1WT1, MYOD1, MYOG, KRT18, PAX3, PAX7
27serine458.0WT1, FOXO1, DES, MYOD1, MYOG, KRT18
28testosterone45 60 11 2410.9ACTC1, WT1, FOXO1, DES, MYOD1, MYOG
29vegf457.9WT1, FOXO1, DES, MYOD1, MYOG, KRT18
30estrogen457.8WT1, FOXO1, DES, MYOD1, MYOG, KRT18
31tyrosine457.4WT1, FOXO1, DES, MYOD1, MYOG, KRT18

GO Terms for genes affiliated with Botryoid Rhabdomyosarcoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1spinal cord association neuron differentiationGO:0215279.9PAX3, PAX7
2neuron fate commitmentGO:0486639.8PAX3, PAX7
3tissue developmentGO:0098889.8FOXO1, WT1
4muscle cell fate commitmentGO:0426939.6MYOD1, MYOG
5skeletal muscle fiber developmentGO:0487419.6MYOG, MYOD1
6cellular response to estradiol stimulusGO:0713929.6MYOG, MYOD1
7muscle filament slidingGO:0300499.6ACTC1, DES
8cellular response to starvationGO:0092679.4MYOD1, FOXO1
9positive regulation of muscle cell differentiationGO:0511499.3MYOG, MYOD1
10skeletal muscle tissue developmentGO:0075199.3MYOG, MYOD1
11muscle cell differentiationGO:0426929.2MYOD1, MYOG
12negative regulation of apoptotic processGO:0430669.0PAX7, KRT18, FOXO1, WT1
13apoptotic processGO:0069158.9FOXO1, KRT18, ACTC1, PAX3
14positive regulation of transcription from RNA polymerase II promoterGO:0459448.2PAX7, PAX3, MYOG, MYOD1, FOXO1

Molecular functions related to Botryoid Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1E-box bindingGO:0708889.3MYOG, MYOD1
2chromatin DNA bindingGO:0314909.2MYOD1, MYOG
3core promoter bindingGO:0010479.0MYOG, MYOD1
4sequence-specific DNA bindingGO:0435658.7PAX7, PAX3, FOXO1, WT1

Products for genes affiliated with Botryoid Rhabdomyosarcoma

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Sources for Botryoid Rhabdomyosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet