MCID: BTL001
MIFTS: 60

Botulism malady

Rare diseases, Infectious diseases, Neuronal diseases, Muscle diseases categories
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Summaries for Botulism

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MedlinePlus:33 Botulism is a rare but serious illness. the cause is a toxin (poison) made by a bacterium called clostridium botulinum. it occurs naturally in soil. there are several kinds of botulism. foodborne botulism comes from eating foods contaminated with the toxin. wound botulism happens when a wound infected with the bacteria makes the toxin. it is more common in heroin users. infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. all forms can be deadly and are medical emergencies. symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. treatment may include antitoxins, intensive medical care, or surgery of infected wounds. to prevent botulism: be very careful when canning foods at home do not let babies eat honey get prompt medical care for infected wounds centers for disease control and prevention

MalaCards based summary: Botulism, also known as foodborne botulism, is related to wound botulism and intestinal botulism, and has symptoms including pupillary anomalies/mydriasis/myosis/tonic pupil, diplopia/double vision and mouth dryness/xerostomia. An important gene associated with Botulism is LY96 (lymphocyte antigen 96), and among its related pathways are Neurotransmitter Release Cycle and Insulin Signaling. The compounds mgatp and n-ethylmaleimide have been mentioned in the context of this disorder. Affiliated tissues include neuromuscular junction, testes and colon, and related mouse phenotype reproductive system.

Disease Ontology:8 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (bonta, b, e and f) located in neuromuscular junction, resulting in descending muscle paralysis, has material basis in clostridium botulinum a, has material basis in clostridium botulinum b, has material basis in clostridium botulinum e and has material basis in clostridium botulinum f.

CDC:3 Colored transmission electron micrograph of the Gram-positive anaerobic bacteria, Clostridium botulinum

Wikipedia:65 Botulism (Latin, botulus, a sausage) (pronounced /?b?t??l?z?m/) is a rare and potentially fatal... more...

Aliases & Classifications for Botulism

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Sources:
42NIH Rare Diseases, 62UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 57SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Botulism, Aliases & Descriptions:

Name: Botulism 8 42 10 44 48 33
Foodborne Botulism 8 42
Infant Botulism 42 62
Wound Botulism 42 62
 
Intoxication with Clostridium Botulinum Toxin 8
Food Poisoning Due to Clostridium Botulinum 8
Infection Due to Clostridium Botulinum 8
Botulism Poisoning 8


Classifications:



Characteristics (Orphanet epidemiological data):

48
botulism:
Prevalence: <1/1000000; Age of onset: Variable; Age of death: Any age


External Ids:

Disease Ontology8 DOID:11976
MeSH34 D001906
NCIt39 C84599
MESH via Orphanet35 D001906
ICD10 via Orphanet26 A05.1
UMLS via Orphanet63 C0006057
ICD1025 A05.1

Related Diseases for Botulism

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Graphical network of the top 20 diseases related to Botulism:



Diseases related to botulism

Symptoms for Botulism

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Symptoms:

48 (show all 18)
  • pupillary anomalies/mydriasis/myosis/tonic pupil
  • diplopia/double vision
  • mouth dryness/xerostomia
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • acute abdominal pain/colic
  • diaphragmatic palsy
  • cranial nerves palsy
  • acute palsy
  • elocution disorders/dysarthria/dysphonia
  • muscle weakness/flaccidity
  • asthenia/fatigue/weakness
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • constipation
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cardiac rhythm disorder/arrhythmia
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • acute diarrhea
  • early death/lethality

HPO human phenotypes related to Botulism:

(show all 15)
id Description Frequency HPO Source Accession
1 xerostomia hallmark (90%) HP:0000217
2 abnormality of the pupil hallmark (90%) HP:0000615
3 diplopia hallmark (90%) HP:0000651
4 abdominal pain hallmark (90%) HP:0002027
5 neurological speech impairment hallmark (90%) HP:0002167
6 diaphragmatic paralysis hallmark (90%) HP:0006597
7 cranial nerve paralysis hallmark (90%) HP:0006824
8 feeding difficulties in infancy hallmark (90%) HP:0008872
9 cerebral palsy hallmark (90%) HP:0100021
10 nausea and vomiting typical (50%) HP:0002017
11 constipation typical (50%) HP:0002019
12 respiratory insufficiency typical (50%) HP:0002093
13 arrhythmia typical (50%) HP:0011675
14 abnormal renal physiology typical (50%) HP:0012211
15 diarrhea occasional (7.5%) HP:0002014

Drugs & Therapeutics for Botulism

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Drug clinical trials:

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Search NIH Clinical Center for Botulism

Genetic Tests for Botulism

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Anatomical Context for Botulism

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MalaCards organs/tissues related to Botulism:

32
Testes, Colon, Lung, Breast, Skin, Bone, Heart, Bone marrow

FMA organs/tissues related to Botulism:

14
Neuromuscular junction

Animal Models for Botulism or affiliated genes

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MGI Mouse Phenotypes related to Botulism:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.0NR0B1, SYT2, SNAP25, TSN, F2

Publications for Botulism

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Articles related to Botulism:

(show top 50)    (show all 695)
idTitleAuthorsYear
1
Infant botulism with prolonged faecal excretion of botulinum neurotoxin and Clostridium botulinum for 7 months. (23688392)
2014
2
Molecular epidemiology of infant botulism in california and elsewhere, 1976-2010. (24924163)
2014
3
Presence of Clostridium botulinum and botulinum toxin in milk and udder tissue of dairy cows with suspected botulism. (23585115)
2013
4
The workshop on animal botulism in Europe. (23971805)
2013
5
Notes from the field: botulism from drinking prison-made illicit alcohol - Arizona, 2012. (23388552)
2013
6
Investigation of serology for diagnosis of outbreaks of botulism in cattle. (21955441)
2012
7
Recurrent wound botulism among injection drug users in California. (21317399)
2011
8
Two unlinked cases of foodborne botulism in Italy at the beginning of 2010. (21811749)
2011
9
Epidemiology of foodborne botulism in Romania 1980-2009. (21495856)
2011
10
The ripe olive scare and hotel Loch Maree tragedy: Botulism under glass in the 1920's. (21563914)
2011
11
Botulism in cattle associated with poultry litter. (21685421)
2011
12
Three outbreaks of foodborne botulism caused by unsafe home canning of vegetables--Ohio and Washington, 2008 and 2009. (22186049)
2011
13
Outbreak of botulism (Clostridium botulinum type C) in wild waterfowl: Seoul, Korea. (20688704)
2010
14
Botulism, where are we now? (21171845)
2010
15
A brief history of botulism in South Africa. (19967922)
2009
16
Infant Botulism and Raised Intraocular Pressure. (19873952)
2009
17
Infant botulism. (19636165)
2009
18
Botulism and hot-smoked whitefish: a family cluster of type E botulism in France, September 2009. (19941787)
2009
19
Wound botulism from heroin skin popping. (18957182)
2008
20
Hematologic and biochemistry values for black-faced spoonbills (Platalea minor) with and recovering from botulism. (18689672)
2008
21
Infant botulism and treatment with BIG-IV (BabyBIG). (17484226)
2007
22
A case of infant botulism with a possible link to infant formula milk powder: evidence for the presence of more than one strain of Clostridium botulinum in clinical specimens and food. (16014431)
2005
23
Foodborne botulism in the Republic of Georgia. (15498162)
2004
24
Public perceptions and risk communications for botulism. (15588060)
2004
25
Infant botulism: a diagnostic and management challenge. (14671769)
2003
26
A botulism case of a 12-year-old girl caused by intestinal colonization of Clostridium botulinum type Ab. (12824692)
2003
27
Anthrax, botulism and tularemia in Italy. (12749299)
2003
28
Botulism: a laboratory investigation on biological and food samples from cases and outbreaks in Brazil (1982-2001). (12532215)
2002
29
Foodborne botulism from eating home-pickled eggs--Illinois, 1997. (10987245)
2000
30
Cardiac arrest due to succinylcholine-induced hyperkalemia in a patient with wound botulism. (10773516)
2000
31
The botulism hazard. (9163303)
1997
32
Wound botulism--California, 1995. From the Center for Disease Control and Prevention. (8531319)
1996
33
Foodborne botulism--Oklahoma, 1994. (7885310)
1995
34
Wound botulism--California, 1995. (7476845)
1995
35
Sequence of the gene coding for the neurotoxin of Clostridium botulinum type A associated with infant botulism: comparison with other clostridial neurotoxins. (8310180)
1993
36
Distinction between Clostridium botulinum type A strains associated with food-borne botulism and those with infant botulism in Japan in intraintestinal toxin production in infant mice and some other properties. (1905658)
1991
37
An outbreak of type A foodborne botulism in Taiwan due to commercially preserved peanuts. (3225100)
1988
38
Infant botulism. (3767793)
1986
39
Infant botulism. (2878137)
1986
40
Infant botulism: anticipating the second decade. (3522756)
1986
41
Rapid diagnosis of a case of infant botulism by enzyme immunoassay. (3895179)
1985
42
Epidemiologic study of infant botulism in Pennsylvania: Report of the Infant Botulism Study group. (3991282)
1985
43
Leads from the MMWR. Infant botulism--Massachusetts. (6716572)
1984
44
Electrodiagnosis in the evaluation of progressive hypotonia in infancy with particular reference to infant botulism. (6950120)
1982
45
Atypical toxin variant of Clostridium botulinum type B associated with infant botulism. (7037830)
1981
46
Infant botulism. (386749)
1979
47
Prolonged respiratory paralysis in wound botulism. (421526)
1979
48
Infant botulism: new guise for an old disease. (83280)
1978
49
Infant botulism. Identification of Clostridium botulinum and its toxins in faeces. (62164)
1976
50
Interconversion of bacterial agents causing botulism and gas gangrene. (165441)
1975

Variations for Botulism

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Expression for genes affiliated with Botulism

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Expression patterns in normal tissues for genes affiliated with Botulism

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Pathways for genes affiliated with Botulism

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Pathways related to Botulism according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7SNAP25, VAMP2
29.3VAMP2, SNAP23, SNAP25
3
Show member pathways
Nicotine Activity on Dopaminergic Neurons37
9.3VAMP2, SNAP23, SNAP25
4
Show member pathways
9.3SNAP25, SNAP23, VAMP2
59.2VAMP2, NSF
6
Show member pathways
Synaptic Vesicle Pathway37
8.9SNAP25, VAMP2, NSF
78.9SNAP25, VAMP2, NSF
8
Show member pathways
8.9SNAP25, VAMP2, NSF
9
Show member pathways
8.8VAMP2, VAPA, SNAP23, SNAP25
10
Show member pathways
8.7NSF, VAMP2, SNAP25, SYT2
11
Show member pathways
8.5SNAP25, SNAP23, VAMP2, NSF

Compounds for genes affiliated with Botulism

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 50PharmGKB
See all sources

Compounds related to Botulism according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mgatp449.3NSF, SNAP25
2n-ethylmaleimide44 119.6SNAP25, SNAP23, VAMP2, NSF
3glucose448.5SNAP25, SNAP23, VAMP2, NSF
4cysteine448.3NSF, SNAP23, SNAP25, NR0B1
5cholesterol44 28 24 1111.2NSF, VAPA, SNAP23, SNAP25, NR0B1
6lipid447.8SNAP25, SNAP23, LY96, VAPA, VAMP2, NSF
7calcium44 50 24 1110.6SYT2, SNAP25, SNAP23, VAMP2, NSF, SV2C

GO Terms for genes affiliated with Botulism

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Cellular components related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle membraneGO:0306669.8SYT2, VAMP2
2SNARE complexGO:0312019.4SNAP25, VAMP2
3synaptic vesicle membraneGO:0306729.3SYT2, VAMP2, SV2C
4neuron projectionGO:0430059.2VAMP2, SNAP23, SNAP25
5cell junctionGO:0300548.6SYT2, SNAP25, SNAP23, VAMP2, SV2C
6plasma membraneGO:0058866.9F2, HCFC2, NSF, VAMP2, VAPA, LY96

Biological processes related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate secretionGO:0140479.7VAMP2, SNAP25
2neurotransmitter secretionGO:0072699.6SYT2, SNAP25, VAMP2
3membrane fusionGO:0610259.4SNAP23, VAPA
4post-Golgi vesicle-mediated transportGO:0068929.3SNAP23, VAMP2
5exocytosisGO:0068879.2SNAP23, NSF
6synaptic transmissionGO:0072688.7SYT2, SNAP25, VAMP2, NSF

Molecular functions related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1syntaxin bindingGO:0199059.2VAMP2, NSF
2protein bindingGO:0055155.9NR0B1, F2, FBXW2, TSN, NSF, VAMP2

Products for genes affiliated with Botulism

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  • Antibodies
  • Proteins
  • Lysates

Sources for Botulism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet