MCID: BTL001
MIFTS: 51

Botulism malady

Infectious, Neuronal categories

Summaries for Botulism

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Botulism is a rare but serious illness. the cause is a toxin (poison) made by a bacterium called clostridium botulinum. it occurs naturally in soil. there are several kinds of botulism. foodborne botulism comes from eating foods contaminated with the toxin. wound botulism happens when a wound infected with the bacteria makes the toxin. it is more common in heroin users. infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. all forms can be deadly and are medical emergencies. symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. treatment may include antitoxins, intensive medical care, or surgery of infected wounds. to prevent botulism: be very careful when canning foods at home do not let babies eat honey get prompt medical care for infected wounds centers for disease control and prevention

MalaCards: Botulism, also known as foodborne botulism, is related to infant botulism and wound botulism, and has symptoms including pupillary anomalies/mydriasis/myosis/tonic pupil, diplopia/double vision and mouth dryness/xerostomia. An important gene associated with Botulism is LY96 (lymphocyte antigen 96), and among its related pathways are Normal wtCFTR traffic / Sorting endosome formation and Botulinum neurotoxicity. The compounds Botulinum Toxin Type B and n-ethylmaleimide have been mentioned in the context of this disorder. Affiliated tissues include neuromuscular junction, bone marrow and heart.

Disease Ontology:8 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (bonta, b, e and f) located in neuromuscular junction, resulting in descending muscle paralysis, has material basis in clostridium botulinum a, has material basis in clostridium botulinum b, has material basis in clostridium botulinum e and has material basis in clostridium botulinum f.

CDC:3 Colored transmission electron micrograph of the Gram-positive anaerobic bacteria, Clostridium botulinum

Wikipedia:64 Botulism (Latin, botulinus) (pronounced /ˈbɒtʃʉlɪzəm/) is, in humans, a rare and sometimes fatal... more...

Aliases & Classifications for Botulism

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
botulism:
Prevalence: <1/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

botulism 8 43 10 45 49 34
foodborne botulism 8 43
wound botulism 43 61
intoxication with clostridium botulinum toxin 8
food poisoning due to clostridium botulinum 8
infection due to clostridium botulinum 8
botulism, infantile 61
botulism poisoning 8
infant botulism 43


External Ids:

Disease Ontology8 DOID:11976
NCIt40 C84599
MeSH35 D001906
SNOMED-CT via Orphanet58 414531002, 398565003
UMLS via Orphanet62 C0006057
MESH via Orphanet36 D001906
ICD10 via Orphanet26 A05.1
ICD1025 A05.1

Related Diseases for Botulism

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Botulism:



Diseases related to botulism

Clinical Features for Botulism

Sources:
49Orphanet
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Symptoms:

49 (show all 18)
  • pupillary anomalies/mydriasis/myosis/tonic pupil
  • diplopia/double vision
  • mouth dryness/xerostomia
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • acute abdominal pain/colic
  • diaphragmatic palsy
  • cranial nerves palsy
  • acute palsy
  • elocution disorders/dysarthria/dysphonia
  • muscle weakness/flaccidity
  • asthenia/fatigue/weakness
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • constipation
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cardiac rhythm disorder/arrhythmia
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • acute diarrhea
  • early death/lethality

Drugs & Therapeutics for Botulism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Botulism

Drug clinical trials:

Search ClinicalTrials for Botulism

Search NIH Clinical Center for Botulism

Search CenterWatch for Botulism

Genetic Tests for Botulism

Anatomical Context for Botulism

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Botulism:

33
Bone marrow, Heart, Small intestine, Colon, Breast, Skin, B cells

FMA organs/tissues related to Botulism:

14
Neuromuscular junction

Animal Models for Botulism or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Botulism

Sources:
51PubMed
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Articles related to Botulism:

(show top 50)    (show all 674)
idTitleAuthorsYear
1
Botulism associated with home-fermented tofu in two Chinese immigrants--New York City, March-April 2012. (23820965)
2013
2
Outbreak of type C botulism in captive wild birds. (22779246)
2012
3
Cranial botulism. (22727688)
2012
4
Recurrent wound botulism among injection drug users in California. (21317399)
2011
5
The ripe olive scare and hotel Loch Maree tragedy: Botulism under glass in the 1920's. (21563914)
2011
6
Neuronal functions associated with endo- and exocytotic events-cum-molecular trafficking may be cell maturation-dependent: lessons learned from studies on botulism. (21625961)
2011
7
Outbreak of type C botulism in laying hens. (21697187)
2011
8
Botulism in the North: a disease without borders. (21292664)
2011
9
Botulism, where are we now? (21171845)
2010
10
Survival of radio-marked mallards in relation to management of avian botulism. (20688692)
2010
11
Real-time PCR for Clostridium botulinum type C neurotoxin (BoNTC) gene, also covering a chimeric C/D sequence--application on outbreaks of botulism in poultry. (20537470)
2010
12
Survival analysis for respiratory failure in patients with food-borne botulism. (20184431)
2010
13
Botulism in 2 urban dogs. (21197207)
2010
14
A brief history of botulism in South Africa. (19967922)
2009
15
Diagnosis and treatment of botulism: a century later, clinical suspicion remains the cornerstone. (19435432)
2009
16
Classification tree methods for development of decision rules for botulism and cyanide poisoning. (18570166)
2008
17
An overview of type E botulism in China. (18837301)
2008
18
Infantile botulism caused by Clostridium butyricum type E toxin. (18054696)
2008
19
Botulism: cause, effects, diagnosis, clinical and laboratory identification, and treatment modalities. (18388640)
2007
20
Recovery from botulism. (17675640)
2007
21
Evaluation of lateral flow assays for the detection of botulinum neurotoxin type A and their application in laboratory diagnosis of botulism. (17141460)
2007
22
Toxicity of Clostridium botulinum type E neurotoxin to Great Lakes fish: implications for avian botulism. (17092878)
2006
23
Equine botulism and acute pasture myodystrophy: new soil-borne emerging diseases in Switzerland? (17076463)
2006
24
Human botulism immune globulin for the treatment of infant botulism. (16452558)
2006
25
A case of infant botulism with a possible link to infant formula milk powder: evidence for the presence of more than one strain of Clostridium botulinum in clinical specimens and food. (16014431)
2005
26
Recent advances in infant botulism. (15730893)
2005
27
Characterization of the neurotoxin produced by isolates associated with avian botulism. (16252491)
2005
28
Botulism: update and review. (15257512)
2004
29
Foodborne botulism in the United States, 1990-2000. (15498163)
2004
30
Clostridium botulinum and the clinical laboratorian: a detailed review of botulism, including biological warfare ramifications of botulinum toxin. (15163234)
2004
31
Food-borne botulism cases in Van region in eastern Turkey: importance of electromyography in the diagnosis. (14535050)
2003
32
From the Centers for Disease Control and Prevention. Infant botulism--New York City, 2001-2002. (12599363)
2003
33
Suspected botulism in dairy cows and its implications for the safety of human food. (11817867)
2002
34
Infant botulism. (11465845)
2001
35
Botulism in critical care: a case study in wound botulism. (11340740)
2001
36
Clostridium botulinum and the ophthalmologist: a review of botulism, including biological warfare ramifications of botulinum toxin. (11525787)
2001
37
Wound botulism in the UK. (11213130)
2001
38
Guillain-BarrAc syndrome mimicking botulism. (11569908)
2001
39
Cardiac arrest due to succinylcholine-induced hyperkalemia in a patient with wound botulism. (10773516)
2000
40
Outbreak of suspected Clostridium butyricum botulism in India. (9716988)
1998
41
Infant botulism. The first culture-confirmed Danish case. (9413010)
1997
42
Bovine botulism in Paraguay. (8888528)
1996
43
Preventing complications in infant botulism. (7889803)
1995
44
Wound botulism. (8144719)
1994
45
Infant botulism in Tennessee. (2214751)
1990
46
Infant botulism: a dilemma for nursing. (3379571)
1988
47
Evaluation of fluorescent-antibody tests as a means of confirming infant botulism. (6394626)
1984
48
Leads from the MMWR. Foodborne botulism--Illinois. (6694270)
1984
49
Clinical characteristics of infant botulism in the United States: a study of the non-California cases. (7145727)
1982
50
Wound botulism. A case report. (4406029)
1974

Genetic Variations for Botulism

Expression for genes affiliated with Botulism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Botulism

Search GEO for disease gene expression data for Botulism.

Pathways for genes affiliated with Botulism

Sources:
54Reactome, 30KEGG, 50PharmGKB, 12EMD Millipore
See all sources

Pathways related to Botulism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Normal wtCFTR traffic / Sorting endosome formation
10.0VAMP2, SNAP25
2
Hide members
9.8VAMP2, SYT2, SNAP25
39.7VAMP2, SNAP23, SNAP25
4
Hide members
9.7SNAP25, SNAP23, VAMP2
59.5BIN1, VAMP2, SNAP23, SNAP25

Compounds for genes affiliated with Botulism

Sources:
11DrugBank, 45Novoseek
See all sources

Compounds related to Botulism according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Botulinum Toxin Type B1110.1VAMP2, SYT2
2n-ethylmaleimide45 1110.2PAX3, VAMP2, SNAP23, SNAP25

GO Terms for genes affiliated with Botulism

Sources:
16Gene Ontology
See all sources

Cellular components related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complexGO:0700329.9VAMP2, SNAP25
2neuron projectionGO:0430059.7VAMP2, SNAP23, SNAP25
3cell junctionGO:0300549.2VAMP2, SYT2, SNAP23, SNAP25

Biological processes related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate secretionGO:01404710.0VAMP2, SNAP25
2neurotransmitter secretionGO:0072699.5VAMP2, SYT2, SNAP25

Molecular functions related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.0LY96, SNAP25, SNAP23, FBXW2, SYT2, NR0B1

Products for genes affiliated with Botulism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Botulism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet