MCID: BTL001
MIFTS: 55

Botulism malady

Infectious diseases, Neuronal diseases categories

Summaries for Botulism

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Botulism is a rare but serious illness. the cause is a toxin (poison) made by a bacterium called clostridium botulinum. it occurs naturally in soil. there are several kinds of botulism. foodborne botulism comes from eating foods contaminated with the toxin. wound botulism happens when a wound infected with the bacteria makes the toxin. it is more common in heroin users. infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. all forms can be deadly and are medical emergencies. symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. treatment may include antitoxins, intensive medical care, or surgery of infected wounds. to prevent botulism: be very careful when canning foods at home do not let babies eat honey get prompt medical care for infected wounds centers for disease control and prevention

MalaCards: Botulism, also known as foodborne botulism, is related to infant botulism and wound botulism, and has symptoms including diaphragmatic palsy, acute diarrhea and acute palsy. An important gene associated with Botulism is LY96 (lymphocyte antigen 96), and among its related pathways are Normal wtCFTR traffic / Sorting endosome formation and Botulinum neurotoxicity. The compounds Botulinum Toxin Type B and n-ethylmaleimide have been mentioned in the context of this disorder. Affiliated tissues include neuromuscular junction, testes and colon.

Disease Ontology:8 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (bonta, b, e and f) located in neuromuscular junction, resulting in descending muscle paralysis, has material basis in clostridium botulinum a, has material basis in clostridium botulinum b, has material basis in clostridium botulinum e and has material basis in clostridium botulinum f.

CDC:3 Colored transmission electron micrograph of the Gram-positive anaerobic bacteria, Clostridium botulinum

Wikipedia:63 Botulism (Latin, botulinus) (pronounced /ˈbɒtʃʉlɪzəm/) is a rare and potentially fatal paralytic... more...

Aliases & Classifications for Botulism

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Sources:
42NIH Rare Diseases, 60UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 56SNOMED-CT, 39NCIt, 34MeSH, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
botulism:
Prevalence: <1/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

botulism 8 42 10 44 48 33
foodborne botulism 8 42
wound botulism 42 60
intoxication with clostridium botulinum toxin 8
food poisoning due to clostridium botulinum 8
infection due to clostridium botulinum 8
botulism, infantile 60
botulism poisoning 8
infant botulism 42


External Ids:

Disease Ontology8 DOID:11976
NCIt39 C84599
MeSH34 D001906
SNOMED-CT via Orphanet57 414531002, 398565003
UMLS via Orphanet61 C0006057
MESH via Orphanet35 D001906
ICD10 via Orphanet26 A05.1
ICD1025 A05.1

Related Diseases for Botulism

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Botulism:



Diseases related to botulism

Clinical Features for Botulism

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Sources:
48Orphanet
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Symptoms:

48 (show all 18)
  • diaphragmatic palsy
  • acute diarrhea
  • acute palsy
  • pupillary anomalies/mydriasis/myosis/tonic pupil
  • acute abdominal pain/colic
  • mouth dryness/xerostomia
  • diplopia/double vision
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • constipation
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • elocution disorders/dysarthria/dysphonia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • muscle weakness/flaccidity
  • early death/lethality
  • asthenia/fatigue/weakness
  • cranial nerves palsy
  • cardiac rhythm disorder/arrhythmia
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Botulism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Botulism

Drug clinical trials:

Search ClinicalTrials for Botulism

Search NIH Clinical Center for Botulism

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Genetic Tests for Botulism

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Anatomical Context for Botulism

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Botulism:

32
Testes, Colon, Lung, Breast, Skin, Bone, Heart, Bone marrow

FMA organs/tissues related to Botulism:

14
Neuromuscular junction

Animal Models for Botulism or affiliated genes

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Publications for Botulism

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Sources:
50PubMed
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Articles related to Botulism:

(show top 50)    (show all 676)
idTitleAuthorsYear
1
An outbreak of foodborne botulism in Surat Thani Province, Thailand, 2012. (23883854)
2013
2
3,4-Diaminopyridine may improve neuromuscular block during botulism. (24007658)
2013
3
Three outbreaks of foodborne botulism caused by unsafe home canning of vegetables--Ohio and Washington, 2008 and 2009. (22186049)
2011
4
Equine botulinum antitoxin for the treatment of infant botulism. (21918119)
2011
5
Effect of adjuvants on antibody titer of synthetic recombinant light chain of botulinum neurotoxin type B and its diagnostic potential for botulism. (21791958)
2011
6
Cases of botulism in cattle and sheep associated with poultry litter. (21774105)
2011
7
Two cases of food-borne botulism in Finland caused by conserved olives, October 2011. (22172330)
2011
8
Wound botulism in drug users: a still underestimated diagnosis. (20552239)
2010
9
Multilocus outbreak of foodborne botulism linked to contaminated sausage in Hebei province, China. (20569065)
2010
10
Infant Botulism and Raised Intraocular Pressure. (19873952)
2009
11
Botulism and its relevance to public health preparedness. (19639768)
2009
12
Plastic bags and botulism: a new twist to an old hazard of the North. 1976. (18491806)
2008
13
Major outbreak of suspected botulism in a dairy herd in the Republic of Ireland. (18375985)
2008
14
Iatrogenic botulism due to therapeutic botulinum toxin a injection in a pediatric patient. (17909312)
2007
15
Rapid geographical clustering of wound botulism in Germany after subcutaneous and intramuscular injection of heroin. (17356188)
2007
16
Infant botulism presenting with poor feeding and lethargy: a review of 4 cases. (17666936)
2007
17
Infant botulism. (16473839)
2006
18
Botulism in a pregnant intravenous drug abuser. (16409344)
2006
19
Infant botulism acquired from household dust presenting as sudden infant death syndrome. (15635031)
2005
20
Infant botulism: a diagnostic and management challenge. (14671769)
2003
21
Current concepts in botulism: clinical and electrophysiological aspects. (19078706)
2003
22
Outbreak of botulism type B in a dairy cattle herd: clinical and epidemiological aspects. (12974340)
2003
23
Infant botulism--New York City, 2001-2002. (12608714)
2003
24
Wound botulism after drug injection]. (11821991)
2002
25
Botulism among Alaska natives in the Bristol Bay area of southwest Alaska: a survey of knowledge, attitudes, and practices related to fermented foods known to cause botulism. (12002947)
2002
26
Botulism outbreak associated with eating fermented food--Alaska, 2001. (11785568)
2001
27
Clinical predictors of respiratory failure and long-term outcome in black tar heroin-associated wound botulism. (11502659)
2001
28
Microbiological investigation into wound botulism. (10870286)
2000
29
Risk of infant botulism from corn syrup. (10877185)
2000
30
Botulism surveillance in Italy: 1992-1996. (10669126)
1999
31
Intestinal toxemia botulism in two young people, caused by Clostridium butyricum type E. (10585782)
1999
32
Index of suspicion. Case 3. Infantile botulism. (9919052)
1999
33
Characterization of Clostridium botulinum type B neurotoxin associated with infant botulism in japan. (9746583)
1998
34
Type E botulism associated with vacuum-packaged hot-smoked whitefish. (9761332)
1998
35
A second case of infant botulism type F caused by Clostridium baratii. (8584326)
1995
36
A case of infant botulism. (7689022)
1993
37
Infant botulism: a case series and review of the literature. (1491154)
1992
38
Electrodiagnosis reliability in the diagnosis of infant botulism. (1315854)
1992
39
Infant botulism in Asia. (3277391)
1988
40
A case of wound botulism. (2882064)
1987
41
Kinetics of growth and toxigenicity of Clostridium botulinum in experimental wound botulism. (3894236)
1985
42
Leads from the MMWR. Infant botulism--Massachusetts. (6716572)
1984
43
Descending paralysis resulting from occult wound botulism. (6486740)
1984
44
Protective role of human milk against sudden death from infant botulism. (7038077)
1982
45
Atypical toxin variant of Clostridium botulinum type B associated with infant botulism. (7037830)
1981
46
Infant botulism. (7041556)
1981
47
Animal models for the study of infant botulism. (399375)
1979
48
Infant botulism in Australia. (723716)
1978
49
Infant botulism: an unusual cause of intestinal hypomotility. (99006)
1978
50
Infant botulism. Identification of Clostridium botulinum and its toxins in faeces. (62164)
1976

Genetic Variations for Botulism

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Expression for genes affiliated with Botulism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Botulism

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Pathways for genes affiliated with Botulism

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53Reactome, 29KEGG, 49PharmGKB, 12EMD Millipore
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Pathways related to Botulism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Normal wtCFTR traffic / Sorting endosome formation
10.0VAMP2, SNAP25
2
Hide members
9.8SNAP25, SYT2, VAMP2
39.7VAMP2, SNAP25, SNAP23
4
Hide members
9.7SNAP23, VAMP2, SNAP25
59.5BIN1, SNAP23, SNAP25, VAMP2

Compounds for genes affiliated with Botulism

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11DrugBank, 44Novoseek
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Compounds related to Botulism according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Botulinum Toxin Type B1110.1VAMP2, SYT2
2n-ethylmaleimide44 1110.2PAX3, VAMP2, SNAP23, SNAP25

GO Terms for genes affiliated with Botulism

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16Gene Ontology
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Cellular components related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complexGO:0700329.9VAMP2, SNAP25
2neuron projectionGO:0430059.7VAMP2, SNAP23, SNAP25
3cell junctionGO:0300549.2VAMP2, SYT2, SNAP23, SNAP25

Biological processes related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate secretionGO:01404710.0VAMP2, SNAP25
2neurotransmitter secretionGO:0072699.5VAMP2, SYT2, SNAP25

Molecular functions related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.0LY96, SNAP25, SNAP23, FBXW2, SYT2, NR0B1

Products for genes affiliated with Botulism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Botulism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet