MCID: BTL001
MIFTS: 55

Botulism malady

Infectious diseases, Neuronal diseases categories

Summaries for Botulism

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Botulism is a rare but serious illness. the cause is a toxin (poison) made by a bacterium called clostridium botulinum. it occurs naturally in soil. there are several kinds of botulism. foodborne botulism comes from eating foods contaminated with the toxin. wound botulism happens when a wound infected with the bacteria makes the toxin. it is more common in heroin users. infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. all forms can be deadly and are medical emergencies. symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. treatment may include antitoxins, intensive medical care, or surgery of infected wounds. to prevent botulism: be very careful when canning foods at home do not let babies eat honey get prompt medical care for infected wounds centers for disease control and prevention

MalaCards: Botulism, also known as foodborne botulism, is related to infant botulism and wound botulism, and has symptoms including diaphragmatic palsy, acute diarrhea and acute palsy. An important gene associated with Botulism is LY96 (lymphocyte antigen 96), and among its related pathways are Normal wtCFTR traffic / Sorting endosome formation and Botulinum neurotoxicity. The compounds Botulinum Toxin Type B and n-ethylmaleimide have been mentioned in the context of this disorder. Affiliated tissues include neuromuscular junction, testes and colon.

Disease Ontology:8 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (bonta, b, e and f) located in neuromuscular junction, resulting in descending muscle paralysis, has material basis in clostridium botulinum a, has material basis in clostridium botulinum b, has material basis in clostridium botulinum e and has material basis in clostridium botulinum f.

CDC:3 Colored transmission electron micrograph of the Gram-positive anaerobic bacteria, Clostridium botulinum

Wikipedia:63 Botulism (Latin, botulinus) (pronounced /ˈbɒtʃʉlɪzəm/) is a rare and potentially fatal paralytic... more...

Aliases & Classifications for Botulism

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
botulism:
Prevalence: <1/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

botulism 8 42 10 44 48 33
foodborne botulism 8 42
wound botulism 42 60
intoxication with clostridium botulinum toxin 8
food poisoning due to clostridium botulinum 8
infection due to clostridium botulinum 8
botulism, infantile 60
botulism poisoning 8
infant botulism 42


External Ids:

Disease Ontology8 DOID:11976
NCIt39 C84599
MeSH34 D001906
SNOMED-CT via Orphanet57 414531002, 398565003
UMLS via Orphanet61 C0006057
MESH via Orphanet35 D001906
ICD10 via Orphanet26 A05.1
ICD1025 A05.1

Related Diseases for Botulism

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Botulism:



Diseases related to botulism

Clinical Features for Botulism

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Sources:
48Orphanet
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Symptoms:

48 (show all 18)
  • diaphragmatic palsy
  • acute diarrhea
  • acute palsy
  • pupillary anomalies/mydriasis/myosis/tonic pupil
  • acute abdominal pain/colic
  • mouth dryness/xerostomia
  • diplopia/double vision
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • constipation
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • elocution disorders/dysarthria/dysphonia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • muscle weakness/flaccidity
  • early death/lethality
  • asthenia/fatigue/weakness
  • cranial nerves palsy
  • cardiac rhythm disorder/arrhythmia
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Botulism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Botulism

Drug clinical trials:

Search ClinicalTrials for Botulism

Search NIH Clinical Center for Botulism

Search CenterWatch for Botulism

Genetic Tests for Botulism

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Anatomical Context for Botulism

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Botulism:

32
Testes, Colon, Lung, Breast, Skin, Bone, Heart, Bone marrow

FMA organs/tissues related to Botulism:

14
Neuromuscular junction

Animal Models for Botulism or affiliated genes

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Publications for Botulism

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Sources:
50PubMed
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Articles related to Botulism:

(show top 50)    (show all 676)
idTitleAuthorsYear
1
Persistent neurogenic bladder dysfunction due to infantile botulism. (24419642)
2014
2
Notes from the field: botulism from drinking prison-made illicit alcohol - Arizona, 2012. (23388552)
2013
3
Infant botulism: advice on avoiding feeding honey to babies and other possible risk factors. (23914481)
2013
4
Diplopia as the primary presentation of foodborne botulism. (22993467)
2012
5
Botulism challenge studies of a modified atmosphere package for fresh mussels: inoculated pack studies. (22691489)
2012
6
Avian botulism and avian chlamydiosis in wild water birds, Benton Lake National Wildlife Refuge, Montana, USA. (23272358)
2012
7
Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism. (21832053)
2011
8
Two outbreaks of botulism associated with consumption of green olive paste, France, September 2011. (22172329)
2011
9
One collective case of type A foodborne botulism in Corsica. (21970773)
2011
10
Characterization of the D/C mosaic neurotoxin produced by Clostridium botulinum associated with bovine botulism in Japan. (19720474)
2010
11
Single-Breath-Count Test: an important adjunct in the triaging of patients in a mass-casualty incident due to botulism. (20586014)
2010
12
Type A botulism in horses in the United States: a review of the past ten years (1998-2008). (20224073)
2010
13
BoTULS: a multicentre randomised controlled trial to evaluate the clinical effectiveness and cost-effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A. (20515600)
2010
14
Cluster of botulism among Dutch tourists in Turkey, June 2008. (20394717)
2010
15
Foodborne botulism in southwest Romania during the post-communism period 1990-2007. (19535277)
2010
16
A six month-old girl with botulism due to honey ingestion. (19805993)
2009
17
Cortical recovery of swallowing function in wound botulism. (18462489)
2008
18
Diagnostic pitfall: wound botulism in an intoxicated intravenous drug abuser presenting with respiratory failure. (17393137)
2007
19
Iatrogenic botulism in a child with spastic quadriparesis. (17940253)
2007
20
Botulism in patients who inhale cocaine: the first cases in France. (16886143)
2006
21
Infant botulism due to consumption of contaminated commercially prepared honey. First report from the Arabian Gulf States. (17047355)
2006
22
Botulism: the many faces of botulinum toxin and its potential for bioterrorism. (16762741)
2006
23
Laboratory diagnostics of botulism. (16614251)
2006
24
Botulism from home-canned bamboo shoots--Nan Province, Thailand, March 2006. (16617285)
2006
25
Acute paralysis following &quot;a bad potato&quot;: a case of botulism. (15817444)
2005
26
Food-borne botulism. (15847370)
2004
27
Anthrax, botulism and tularemia in Italy. (12749299)
2003
28
Mechanical ventilation in foals with botulism: 9 cases (1989-2002). (14529139)
2003
29
Airway complications of infant botulism: ten-year experience with 60 cases. (11956530)
2002
30
Wound botulism in California, 1951-1998: recent epidemic in heroin injectors. (11049786)
2000
31
Development of vaccines for prevention of botulism. (11086225)
2000
32
An outbreak of food-borne botulism. (10457885)
1999
33
Clostridium difficile colitis associated with infant botulism: near-fatal case analogous to Hirschsprung's enterocolitis. (10476744)
1999
34
Surveillance of foodborne botulism in Poland: 1960-1998. (12631899)
1999
35
Botulism in the European Union. (12631917)
1999
36
Infant botulism during a one year period in San Luis, Argentina. (9532265)
1998
37
Infant botulism. (9336680)
1997
38
An outbreak of type A botulism associated with a commercial cheese sauce. (8815754)
1996
39
A case of infant botulism associated with honey feeding in Italy. (8150073)
1993
40
Attempts to quantity Clostridium botulinum type A toxin and antitoxin in serum of two cases of infant botulism in Japan. (2101138)
1990
41
Infant botulism. (2878137)
1986
42
Infant botulism: a rare entity in Canada? (3521822)
1986
43
Rapid diagnosis of a case of infant botulism by enzyme immunoassay. (3895179)
1985
44
Infant botulism--Massachusetts. (6590974)
1984
45
Wound botulism. (7421626)
1980
46
Prolonged respiratory paralysis in wound botulism. (421526)
1979
47
Potentiation of neuromuscular weakness in infant botulism by aminoglycosides. (501488)
1979
48
Current perspectives and priorities for research in infant botulism. (551515)
1979
49
Infant botulism in England. (78046)
1978
50
Interconversion of bacterial agents causing botulism and gas gangrene. (165441)
1975

Genetic Variations for Botulism

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Expression for genes affiliated with Botulism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Botulism

Search GEO for disease gene expression data for Botulism.

Pathways for genes affiliated with Botulism

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53Reactome, 29KEGG, 49PharmGKB, 12EMD Millipore
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Pathways related to Botulism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Normal wtCFTR traffic / Sorting endosome formation
10.0VAMP2, SNAP25
2
Hide members
9.8VAMP2, SYT2, SNAP25
39.7VAMP2, SNAP23, SNAP25
4
Hide members
9.7SNAP25, SNAP23, VAMP2
59.5BIN1, VAMP2, SNAP23, SNAP25

Compounds for genes affiliated with Botulism

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11DrugBank, 44Novoseek
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Compounds related to Botulism according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Botulinum Toxin Type B1110.1VAMP2, SYT2
2n-ethylmaleimide44 1110.2PAX3, VAMP2, SNAP23, SNAP25

GO Terms for genes affiliated with Botulism

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16Gene Ontology
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Cellular components related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complexGO:0700329.9VAMP2, SNAP25
2neuron projectionGO:0430059.7VAMP2, SNAP23, SNAP25
3cell junctionGO:0300549.2VAMP2, SYT2, SNAP23, SNAP25

Biological processes related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate secretionGO:01404710.0VAMP2, SNAP25
2neurotransmitter secretionGO:0072699.5VAMP2, SYT2, SNAP25

Molecular functions related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.0LY96, SNAP25, SNAP23, FBXW2, SYT2, NR0B1

Products for genes affiliated with Botulism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Botulism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet