MCID: BTL001
MIFTS: 50

Botulism malady

Rare diseases, Infectious diseases, Neuronal diseases, Muscle diseases categories

Aliases & Classifications for Botulism

About this section
Sources:
10Disease Ontology, 45NIH Rare Diseases, 65UMLS, 47Novoseek, 12DISEASES, 51Orphanet, 35MedlinePlus, 2CDC, 36MeSH, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Botulism:

Name: Botulism 10 45 47 12 51 35 2 36
Foodborne Botulism 10 45
Wound Botulism 45 65
Intoxication with Clostridium Botulinum Toxin 10
Food Poisoning Due to Clostridium Botulinum 10
 
Infection Due to Clostridium Botulinum 10
Botulism, Infantile 65
Botulism Poisoning 10
Infant Botulism 45


Classifications:



Characteristics (Orphanet epidemiological data):

51
botulism:
Prevalence: <1/1000000 (Europe),<1/1000000 (Worldwide),1-9/1000000 (France),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age


External Ids:

Disease Ontology10 DOID:11976
NCIt42 C84599
MeSH36 D001906
Orphanet51 1267
ICD10 via Orphanet28 A05.1
MESH via Orphanet37 D001906
UMLS via Orphanet66 C0006057
ICD1027 A05.1

Summaries for Botulism

About this section
MedlinePlus:35 Botulism is a rare but serious illness. the cause is a toxin (poison) made by a bacterium called clostridium botulinum. it occurs naturally in soil. there are several kinds of botulism. foodborne botulism comes from eating foods contaminated with the toxin. wound botulism happens when a wound infected with the bacteria makes the toxin. it is more common in heroin users. infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. all forms can be deadly and are medical emergencies. symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. treatment may include antitoxins, intensive medical care, or surgery of infected wounds. to prevent botulism: be very careful when canning foods at home do not let babies eat honey get prompt medical care for infected wounds centers for disease control and prevention

MalaCards based summary: Botulism, also known as foodborne botulism, is related to wound botulism and infant botulism, and has symptoms including xerostomia, abnormality of the pupil and diplopia. An important gene associated with Botulism is SNAP25 (Synaptosomal-Associated Protein, 25kDa), and among its related pathways are N-Glycan biosynthesis and Delta508-CFTR traffic / Sorting endosome formation in CF. Affiliated tissues include neuromuscular junction, testes and bone, and related mouse phenotype mortality/aging.

Disease Ontology:10 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (bonta, b, e and f) located in neuromuscular junction, resulting in descending muscle paralysis, has material basis in clostridium botulinum a, has material basis in clostridium botulinum b, has material basis in clostridium botulinum e and has material basis in clostridium botulinum f.

Wikipedia:68 Botulism US /ˈbɒtʃʉlɪzəm/ UK /ˈbɒtjʊlɪzəm/ (Latin, botulus, a sausage) is a rare and... more...

Related Diseases for Botulism

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Graphical network of the top 20 diseases related to Botulism:



Diseases related to botulism

Symptoms for Botulism

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Symptoms:

 51 (show all 18)
  • pupillary anomalies/mydriasis/myosis/tonic pupil
  • diplopia/double vision
  • mouth dryness/xerostomia
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • acute abdominal pain/colic
  • diaphragmatic palsy
  • cranial nerves palsy
  • acute palsy
  • elocution disorders/dysarthria/dysphonia
  • muscle weakness/flaccidity
  • asthenia/fatigue/weakness
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • constipation
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cardiac rhythm disorder/arrhythmia
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • acute diarrhea
  • early death/lethality

HPO human phenotypes related to Botulism:

(show all 15)
id Description Frequency HPO Source Accession
1 xerostomia hallmark (90%) HP:0000217
2 abnormality of the pupil hallmark (90%) HP:0000615
3 diplopia hallmark (90%) HP:0000651
4 abdominal pain hallmark (90%) HP:0002027
5 neurological speech impairment hallmark (90%) HP:0002167
6 diaphragmatic paralysis hallmark (90%) HP:0006597
7 cranial nerve paralysis hallmark (90%) HP:0006824
8 feeding difficulties in infancy hallmark (90%) HP:0008872
9 cerebral palsy hallmark (90%) HP:0100021
10 nausea and vomiting typical (50%) HP:0002017
11 constipation typical (50%) HP:0002019
12 respiratory insufficiency typical (50%) HP:0002093
13 arrhythmia typical (50%) HP:0011675
14 abnormal renal physiology typical (50%) HP:0012211
15 diarrhea occasional (7.5%) HP:0002014

Drugs & Therapeutics for Botulism

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Drugs for Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TriamcinoloneapprovedPhase 4429124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Allernaze
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
MLS000028542
MLS001066543
 
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone Acetonide
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Trianex
Triatex
Tricortale
Triderm
Triesence
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
2
LidocaineapprovedPhase 4991137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Afterburn
Akten
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bikini Zone Medicated
Bikini Zone Medicated Creme
Bio-0767
Bio-scriptives Lidum
Bio-scriptives Lidum Hemorroidal (anorectal)
Bio-scriptives Lidum Topical Analgesic
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
Burn Relief Leader
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Comfortcaine
Cuivasil
Curacaine Transdermal Corporation
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
Derma Numb
DermaFlex
Desert Harvest Releveum
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Dr. Numb
Dr. Richs Numbing
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gigi Anesthetic Numbing
Gravocain
H-releve Hemorrhoidal
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
Hawaiian Tropic
Hush Anesthetic
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
LS-805
Lanabiotic
 
Laryng-o-jet
Leostesin
Lida-Mantle
Lidall
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine 4% Cream
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Hydrochloride
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocaine hydrochloride
Lidocainum
Lidocainum [INN-Latin]
Lidocare Mist
Lidocaton
Lidocream 4
Lidocream 5
Lidoderm
Lidoderm 5
Lidoject-1
Lidoject-2
Lifestyles Epic Male Genital Desensitizer
Lignocaine
Lignocainum
Lingocaine
Lmx4
Lmx5
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Numb Master Topical Anesthetic
Numb Nuts
Ocean Potion Instant Burn Relief Ice
Octocaine
Octocaine-100
Octocaine-50
Plum Smooth Plumb Numb Gelee
Premjact Male Desensitizer Pound International
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Recticare
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Simplicity Desensitizing
Simply Numb Endure
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Sole Serum
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Walgreens Aloe Vera Pain Relieving
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocaine-mpf
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zcaine Fast Acting Anesthetic
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
3Triamcinolone diacetatePhase 4429
4Triamcinolone hexacetonidePhase 4429
5triamcinolone acetonidePhase 4429
6Botulinum AntitoxinPhase 4, Phase 16
7Botulinum Toxins, Type APhase 4561
8AntitoxinsPhase 4, Phase 111
9Botulinum ToxinsPhase 4590
10
Aluminum hydroxideapprovedPhase 2169
Synonyms:
Al(OH)3
Aluminiumhydroxid
 
Aluminum Hydroxide
Aluminum hydroxide
Dermadrox

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Botulism Outbreak in Thailand (Episode II)CompletedNCT00348426Phase 4
2Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb JointCompletedNCT01045694Phase 4
3Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.CompletedNCT00320281Phase 4
4BT-011 Pharmacokinetics of Botulism Antitoxin Heptavalent in Pediatric PatientsEnrolling by invitationNCT02051062Phase 4
5Pilot Study on the Usefulness of 3,4-diaminopyridine in the Treatment of BotulismCompletedNCT01441557Phase 2, Phase 3
6Phase 3, Randomized, Safety, Lot Consistency and Clinical Benefit Study of Recombinant Botulinum Vaccine A/BSuspendedNCT01940315Phase 3
7Safety, Tolerability, and Immunogenicity Study of Investigational Recombinant Botulinum Vaccine A/B (rBV A/B) in Volunteers Previously Immunized With Investigational Pentavalent Botulinum ToxoidCompletedNCT01701999Phase 2
8Double Blind, Safety and Immunogenicity Study of Recombinant Botulinum Vaccine A/BCompletedNCT00764634Phase 2
9Botulism Antitoxin Effects on Paralysis Induced by Botulinum Neurotoxins in the EDB MuscleCompletedNCT00636519Phase 1
10Phase 1 PK Study of XOMA 3ABCompletedNCT01357213Phase 1
11Safety Study of 7 Botulinum Antitoxin Serotypes Derived From HorsesCompletedNCT00360737Phase 1
12Study of Human Botulism Immunoglobulin in Infants With BotulismCompletedNCT00004401
13Treatment of Survivors After Botulism OutbreakCompletedNCT00314080
14Effect of Agave Syrup, Placebo, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Infants/Toddlers and Their ParentsCompletedNCT01721395
15Botulinum Toxin for the Treatment of Involuntary Movement DisordersRecruitingNCT00001208
16BT-010 Registry for the Evaluation of Safety and Clinical Outcomes in Patients Treated With Botulinum AntitoxinEnrolling by invitationNCT02055183

Search NIH Clinical Center for Botulism


Cochrane evidence based reviews: Botulism

Genetic Tests for Botulism

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Anatomical Context for Botulism

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MalaCards organs/tissues related to Botulism:

33
Testes, Bone, Colon, Lung, Skin, Breast, Liver

FMA organs/tissues related to Botulism:

16
Neuromuscular junction

Animal Models for Botulism or affiliated genes

About this section

MGI Mouse Phenotypes related to Botulism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.5DPAGT1, SNAP25, SNAP29, SYT1, SYT2, VAMP1

Publications for Botulism

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Articles related to Botulism:

(show top 50)    (show all 729)
idTitleAuthorsYear
1
Stimulated jitter in infant botulism. (26096260)
2015
2
Regional variations in home canning practices and the risk of foodborne botulism in the republic of georgia, 2003. (25836400)
2015
3
An atypical outbreak of food-borne botulism due to Clostridium botulinum types B and E from ham. (25428161)
2015
4
Infant botulism with prolonged faecal excretion of botulinum neurotoxin and Clostridium botulinum for 7 months. (23688392)
2014
5
Molecular epidemiology of infant botulism in california and elsewhere, 1976-2010. (24924163)
2014
6
Presence of Clostridium botulinum and botulinum toxin in milk and udder tissue of dairy cows with suspected botulism. (23585115)
2013
7
The workshop on animal botulism in Europe. (23971805)
2013
8
Notes from the field: botulism from drinking prison-made illicit alcohol - Arizona, 2012. (23388552)
2013
9
Recurrent wound botulism among injection drug users in California. (21317399)
2011
10
Two unlinked cases of foodborne botulism in Italy at the beginning of 2010. (21811749)
2011
11
Epidemiology of foodborne botulism in Romania 1980-2009. (21495856)
2011
12
The ripe olive scare and hotel Loch Maree tragedy: Botulism under glass in the 1920's. (21563914)
2011
13
Botulism in cattle associated with poultry litter. (21685421)
2011
14
Three outbreaks of foodborne botulism caused by unsafe home canning of vegetables--Ohio and Washington, 2008 and 2009. (22186049)
2011
15
Outbreak of botulism (Clostridium botulinum type C) in wild waterfowl: Seoul, Korea. (20688704)
2010
16
Botulism, where are we now? (21171845)
2010
17
A brief history of botulism in South Africa. (19967922)
2009
18
Infant Botulism and Raised Intraocular Pressure. (19873952)
2009
19
Infant botulism. (19636165)
2009
20
Botulism and hot-smoked whitefish: a family cluster of type E botulism in France, September 2009. (19941787)
2009
21
Wound botulism from heroin skin popping. (18957182)
2008
22
Hematologic and biochemistry values for black-faced spoonbills (Platalea minor) with and recovering from botulism. (18689672)
2008
23
Infant botulism and treatment with BIG-IV (BabyBIG). (17484226)
2007
24
A case of infant botulism with a possible link to infant formula milk powder: evidence for the presence of more than one strain of Clostridium botulinum in clinical specimens and food. (16014431)
2005
25
Foodborne botulism in the Republic of Georgia. (15498162)
2004
26
Infant botulism: a diagnostic and management challenge. (14671769)
2003
27
A botulism case of a 12-year-old girl caused by intestinal colonization of Clostridium botulinum type Ab. (12824692)
2003
28
Anthrax, botulism and tularemia in Italy. (12749299)
2003
29
Botulism: a laboratory investigation on biological and food samples from cases and outbreaks in Brazil (1982-2001). (12532215)
2002
30
Foodborne botulism from eating home-pickled eggs--Illinois, 1997. (10987245)
2000
31
Cardiac arrest due to succinylcholine-induced hyperkalemia in a patient with wound botulism. (10773516)
2000
32
The botulism hazard. (9163303)
1997
33
Foodborne botulism--Oklahoma, 1994. (7885310)
1995
34
Wound botulism--California, 1995. (7476845)
1995
35
Sequence of the gene coding for the neurotoxin of Clostridium botulinum type A associated with infant botulism: comparison with other clostridial neurotoxins. (8310180)
1993
36
Distinction between Clostridium botulinum type A strains associated with food-borne botulism and those with infant botulism in Japan in intraintestinal toxin production in infant mice and some other properties. (1905658)
1991
37
An outbreak of type A foodborne botulism in Taiwan due to commercially preserved peanuts. (3225100)
1988
38
Infant botulism. (3767793)
1986
39
Infant botulism. (2878137)
1986
40
Infant botulism: anticipating the second decade. (3522756)
1986
41
Rapid diagnosis of a case of infant botulism by enzyme immunoassay. (3895179)
1985
42
Epidemiologic study of infant botulism in Pennsylvania: Report of the Infant Botulism Study group. (3991282)
1985
43
Leads from the MMWR. Infant botulism--Massachusetts. (6716572)
1984
44
Electrodiagnosis in the evaluation of progressive hypotonia in infancy with particular reference to infant botulism. (6950120)
1982
45
Atypical toxin variant of Clostridium botulinum type B associated with infant botulism. (7037830)
1981
46
Infant botulism. (386749)
1979
47
Prolonged respiratory paralysis in wound botulism. (421526)
1979
48
Infant botulism: new guise for an old disease. (83280)
1978
49
Infant botulism. Identification of Clostridium botulinum and its toxins in faeces. (62164)
1976
50
Interconversion of bacterial agents causing botulism and gas gangrene. (165441)
1975

Variations for Botulism

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Expression for genes affiliated with Botulism

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Search GEO for disease gene expression data for Botulism.

Pathways for genes affiliated with Botulism

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Pathways related to Botulism according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7DPAGT1, TUSC3
2
Show member pathways
9.7SNAP25, VAMP2
3
Show member pathways
9.5VAMP1, VAMP2
4
Show member pathways
9.0SNAP25, SYT1, VAMP2
5
Show member pathways
9.0SNAP25, SYT1, VAMP2
69.0SNAP25, SYT1, VAMP2
7
Show member pathways
8.9SNAP25, SNAP29, VAMP1, VAMP2
88.6SNAP25, SYT1, VAMP1, VAMP2
9
Show member pathways
8.4SNAP25, VAMP1, VAMP2, VAPA
10
Show member pathways
8.3SNAP25, SYT1, SYT2, VAMP1, VAMP2
11
Show member pathways
8.3SNAP25, SYT1, SYT2, VAMP1, VAMP2

GO Terms for genes affiliated with Botulism

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Cellular components related to Botulism according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complexGO:007003210.2SNAP25, VAMP2
2presynaptic membraneGO:004273410.1SNAP25, SYT1
3terminal boutonGO:004319510.0VAMP1, VAMP2
4chromaffin granule membraneGO:004258410.0SYT1, SYT2
5clathrin-sculpted glutamate transport vesicle membraneGO:006020310.0SYT1, VAMP2
6clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:006120210.0SYT1, VAMP2
7clathrin-sculpted monoamine transport vesicle membraneGO:007008310.0SYT1, VAMP2
8vesicleGO:00319829.3SNAP25, VAMP2, VAPA
9synaptic vesicleGO:00080219.3SYT1, VAMP1, VAMP2
10SNARE complexGO:00312019.1SNAP25, SNAP29, VAMP1, VAMP2
11neuron projectionGO:00430059.0SNAP25, SNAP29, SYT1, VAMP2
12synaptic vesicle membraneGO:00306728.9SYT1, SYT2, VAMP1, VAMP2
13cell junctionGO:00300548.3SNAP25, SYT1, SYT2, VAMP1, VAMP2
14plasma membraneGO:00058866.8SNAP25, SNAP29, SYT1, SYT2, TUSC3, VAMP2

Biological processes related to Botulism according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1synaptic vesicle fusion to presynaptic membraneGO:003162910.4SNAP25, SNAP29
2synaptic vesicle primingGO:001608210.2SNAP25, SNAP29
3positive regulation of dendrite extensionGO:190386110.1SYT1, SYT2
4vesicle fusionGO:00069069.9VAMP1, VAMP2
5synaptic vesicle endocytosisGO:00484889.9SYT1, SYT2
6long-term synaptic potentiationGO:00602919.9SNAP25, VAMP2
7protein N-linked glycosylationGO:00064879.9DPAGT1, TUSC3
8regulation of exocytosisGO:00171579.7SYT1, VAMP2
9regulation of calcium ion-dependent exocytosisGO:00171589.5SYT1, SYT2
10exocytosisGO:00068879.5SNAP29, VAMP1, VAMP2
11neurotransmitter secretionGO:00072699.4SNAP25, SYT1, VAMP2
12glutamate secretionGO:00140479.4SNAP25, SYT1, VAMP2
13membrane fusionGO:00610259.3SNAP29, VAMP2, VAPA
14calcium ion-dependent exocytosis of neurotransmitterGO:00487919.2SYT1, SYT2
15synaptic vesicle exocytosisGO:00160798.8SNAP25, SYT1, SYT2, VAMP2
16synaptic transmissionGO:00072688.6SNAP25, SYT1, VAMP1, VAMP2

Molecular functions related to Botulism according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1clathrin bindingGO:00302769.4SYT1, SYT2
2calcium-dependent protein bindingGO:00483069.3SNAP25, SYT1, VAMP2
3syntaxin bindingGO:00199059.3SNAP29, SYT2, VAMP2
4syntaxin-1 bindingGO:00170759.3SNAP25, SYT1, VAMP2
5calcium-dependent phospholipid bindingGO:00055449.2SYT1, SYT2
6SNAP receptor activityGO:00054849.2SNAP25, SNAP29, VAMP1, VAMP2
7SNARE bindingGO:00001498.8SNAP25, SYT1, VAMP1, VAMP2

Sources for Botulism

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet