MCID: BTL001
MIFTS: 55

Botulism malady

Infectious diseases, Neuronal diseases categories

Summaries for Botulism

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Botulism is a rare but serious illness. the cause is a toxin (poison) made by a bacterium called clostridium botulinum. it occurs naturally in soil. there are several kinds of botulism. foodborne botulism comes from eating foods contaminated with the toxin. wound botulism happens when a wound infected with the bacteria makes the toxin. it is more common in heroin users. infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. all forms can be deadly and are medical emergencies. symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. treatment may include antitoxins, intensive medical care, or surgery of infected wounds. to prevent botulism: be very careful when canning foods at home do not let babies eat honey get prompt medical care for infected wounds centers for disease control and prevention

MalaCards: Botulism, also known as foodborne botulism, is related to infant botulism and wound botulism, and has symptoms including diaphragmatic palsy, acute diarrhea and acute palsy. An important gene associated with Botulism is LY96 (lymphocyte antigen 96), and among its related pathways are Normal wtCFTR traffic / Sorting endosome formation and Botulinum neurotoxicity. The compounds Botulinum Toxin Type B and n-ethylmaleimide have been mentioned in the context of this disorder. Affiliated tissues include neuromuscular junction, testes and colon.

Disease Ontology:8 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (bonta, b, e and f) located in neuromuscular junction, resulting in descending muscle paralysis, has material basis in clostridium botulinum a, has material basis in clostridium botulinum b, has material basis in clostridium botulinum e and has material basis in clostridium botulinum f.

CDC:3 Colored transmission electron micrograph of the Gram-positive anaerobic bacteria, Clostridium botulinum

Wikipedia:63 Botulism (Latin, botulinus) (pronounced /ˈbɒtʃʉlɪzəm/) is a rare and potentially fatal paralytic... more...

Aliases & Classifications for Botulism

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
botulism:
Prevalence: <1/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

botulism 8 42 10 44 48 33
foodborne botulism 8 42
wound botulism 42 60
intoxication with clostridium botulinum toxin 8
food poisoning due to clostridium botulinum 8
infection due to clostridium botulinum 8
botulism, infantile 60
botulism poisoning 8
infant botulism 42


External Ids:

Disease Ontology8 DOID:11976
NCIt39 C84599
MeSH34 D001906
SNOMED-CT via Orphanet57 414531002, 398565003
UMLS via Orphanet61 C0006057
MESH via Orphanet35 D001906
ICD10 via Orphanet26 A05.1
ICD1025 A05.1

Related Diseases for Botulism

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Botulism:



Diseases related to botulism

Clinical Features for Botulism

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Sources:
48Orphanet
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Symptoms:

48 (show all 18)
  • diaphragmatic palsy
  • acute diarrhea
  • acute palsy
  • pupillary anomalies/mydriasis/myosis/tonic pupil
  • acute abdominal pain/colic
  • mouth dryness/xerostomia
  • diplopia/double vision
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • constipation
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • elocution disorders/dysarthria/dysphonia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • muscle weakness/flaccidity
  • early death/lethality
  • asthenia/fatigue/weakness
  • cranial nerves palsy
  • cardiac rhythm disorder/arrhythmia
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Botulism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Botulism

Drug clinical trials:

Search ClinicalTrials for Botulism

Search NIH Clinical Center for Botulism

Search CenterWatch for Botulism

Genetic Tests for Botulism

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Anatomical Context for Botulism

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Botulism:

32
Testes, Colon, Lung, Breast, Skin, Bone, Heart, Bone marrow

FMA organs/tissues related to Botulism:

14
Neuromuscular junction

Animal Models for Botulism or affiliated genes

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Publications for Botulism

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Sources:
50PubMed
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Articles related to Botulism:

(show top 50)    (show all 676)
idTitleAuthorsYear
1
Infant botulism: first two confirmed cases in Slovenia and literature review. (23707631)
2013
2
Foodborne botulism in Poland in 2111. (24040723)
2013
3
Vaccines against botulism. (22694934)
2012
4
Type C botulism in a commercial turkey farm: a case report. (23397853)
2012
5
A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model. (22238680)
2012
6
Constipation and poor feeding in an infant with botulism. (22988147)
2012
7
Wound botulism presenting as a deep neck space infection. (22645053)
2012
8
Epidemiology of foodborne botulism in Romania 1980-2009. (21495856)
2011
9
Variant angina in the setting of food-borne botulism. (22080123)
2011
10
Risk of botulism for laying hens and broilers. (21803832)
2011
11
Outbreak of botulism (Clostridium botulinum type C) in wild waterfowl: Seoul, Korea. (20688704)
2010
12
Infant botulism in Australia: availability of human botulinum antitoxin for treatment. (21077820)
2010
13
Type E botulism. (21171846)
2010
14
An efficient drug delivery vehicle for botulism countermeasure. (19860869)
2009
15
Electrodiagnosis of botulism and clinico-electrophysiological correlation. (19410507)
2009
16
Wound botulism in injection drug users: time to antitoxin correlates with intensive care unit length of stay. (20046244)
2009
17
Presence of Clostridium botulinum spores in Matricaria chamomilla (chamomile) and its relationship with infant botulism. (18068252)
2008
18
Denmark: botulism in an infant or infant botulism? (19094919)
2008
19
Subunit vaccine against the seven serotypes of botulism. (18070903)
2008
20
Adeno-associated virus transfer of a gene encoding SNAP-25 resistant to botulinum toxin A attenuates neuromuscular paralysis associated with botulism. (18385326)
2008
21
Medical referral of patients with acute respiratory failure: lessons learned from a large outbreak of botulism in northern Thailand. (17624217)
2007
22
Generalized botulism: diagnostic problems in a patient treated with botulinum toxin type A. (17305749)
2007
23
Botulism associated with commercial carrot juice--Georgia and Florida, September 2006. (17035929)
2006
24
Foodborne botulism in the Republic of Georgia. (15498162)
2004
25
Signs and symptoms predictive of death in patients with foodborne botulism--Republic of Georgia, 1980-2002. (15307002)
2004
26
Beating botulism. (15187726)
2004
27
A severe case of infant botulism caused by Clostridium botulinum type A with concomitant intestinal viral infections. (15170567)
2004
28
Type C botulism due to toxic feed affecting 52,000 farmed foxes and minks in Finland. (15472332)
2004
29
Botulism in foals less than 6 months of age: 30 cases (1989-2002). (14529138)
2003
30
Opiate withdrawal and botulism: stigma delayed treatment. (12689986)
2003
31
Botulism in the horse. (11780288)
2001
32
What's next? It could be smallpox, botulism or other equally deadly biological agents. (11710156)
2001
33
Foodborne botulism from eating home-pickled eggs--Illinois, 1997. (10987245)
2000
34
Biphasic course of infant botulism. (11068167)
2000
35
Outbreak of type A botulism and development of a botulism surveillance and antitoxin release system in Argentina. (10208152)
1999
36
Botulism associated with home-preserved mushrooms. (9611862)
1998
37
Botulism in the United States: a clinical and epidemiologic review. (9696731)
1998
38
Pathogenesis of human botulism. (9668232)
1998
39
Experience with the use of an investigational F(ab')2 heptavalent botulism immune globulin of equine origin during an outbreak of type E botulism in Egypt. (8842274)
1996
40
Wound botulism--California, 1995. From the Center for Disease Control and Prevention. (8531319)
1996
41
Infant botulism: a rare cause of colonic ileus. (7761156)
1995
42
Infant botulism. (8206775)
1994
43
Sequence of the gene coding for the neurotoxin of Clostridium botulinum type A associated with infant botulism: comparison with other clostridial neurotoxins. (8310180)
1993
44
Infant botulism: a review of 12 years' experience at the Children's Hospital of Philadelphia. (1898989)
1991
45
Comparative studies on Clostridium botulinum type A strains associated with infant botulism in Japan and in California, USA. (2129272)
1990
46
Infant botulism--the first five years. (6763147)
1982
47
Wound botulism. (7463544)
1981
48
Progression of clinical signs in severe infant botulism. Therapeutic implications. (6257443)
1981
49
Infant botulism: epidemiology and relation to sudden infant death syndrome. (7030764)
1981
50
Neuromuscular physiology of wound botulism. (4357216)
1973

Genetic Variations for Botulism

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Expression for genes affiliated with Botulism

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Botulism

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Pathways for genes affiliated with Botulism

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53Reactome, 29KEGG, 49PharmGKB, 12EMD Millipore
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Pathways related to Botulism according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Normal wtCFTR traffic / Sorting endosome formation
10.0VAMP2, SNAP25
2
Hide members
9.8VAMP2, SYT2, SNAP25
39.7VAMP2, SNAP23, SNAP25
4
Hide members
9.7SNAP25, SNAP23, VAMP2
59.5BIN1, VAMP2, SNAP23, SNAP25

Compounds for genes affiliated with Botulism

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11DrugBank, 44Novoseek
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Compounds related to Botulism according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Botulinum Toxin Type B1110.1VAMP2, SYT2
2n-ethylmaleimide44 1110.2PAX3, VAMP2, SNAP23, SNAP25

GO Terms for genes affiliated with Botulism

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16Gene Ontology
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Cellular components related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complexGO:0700329.9VAMP2, SNAP25
2neuron projectionGO:0430059.7VAMP2, SNAP23, SNAP25
3cell junctionGO:0300549.2VAMP2, SYT2, SNAP23, SNAP25

Biological processes related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate secretionGO:01404710.0VAMP2, SNAP25
2neurotransmitter secretionGO:0072699.5VAMP2, SYT2, SNAP25

Molecular functions related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.0LY96, SNAP25, SNAP23, FBXW2, SYT2, NR0B1

Products for genes affiliated with Botulism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Botulism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet