MCID: BTL001
MIFTS: 60

Botulism malady

Rare diseases, Infectious diseases, Neuronal diseases, Muscle diseases categories

Summaries for Botulism

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Sources:
9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Botulism is a rare but serious illness. the cause is a toxin (poison) made by a bacterium called clostridium botulinum. it occurs naturally in soil. there are several kinds of botulism. foodborne botulism comes from eating foods contaminated with the toxin. wound botulism happens when a wound infected with the bacteria makes the toxin. it is more common in heroin users. infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. all forms can be deadly and are medical emergencies. symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. treatment may include antitoxins, intensive medical care, or surgery of infected wounds. to prevent botulism: be very careful when canning foods at home do not let babies eat honey get prompt medical care for infected wounds centers for disease control and prevention

MalaCards: Botulism, also known as foodborne botulism, is related to wound botulism and intestinal botulism, and has symptoms including early death/lethality, acute diarrhea and pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria. An important gene associated with Botulism is LY96 (lymphocyte antigen 96), and among its related pathways are Neurotransmitter Release Cycle and Insulin Signaling. The compounds mgatp and n-ethylmaleimide have been mentioned in the context of this disorder. Affiliated tissues include neuromuscular junction, testes and colon, and related mouse phenotype reproductive system.

Disease Ontology:9 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (bonta, b, e and f) located in neuromuscular junction, resulting in descending muscle paralysis, has material basis in clostridium botulinum a, has material basis in clostridium botulinum b, has material basis in clostridium botulinum e and has material basis in clostridium botulinum f.

CDC:4 Colored transmission electron micrograph of the Gram-positive anaerobic bacteria, Clostridium botulinum

Wikipedia:66 Botulism (Latin, botulus, a sausage) (pronounced /?b?t??l?z?m/) is a rare and potentially fatal... more...

Aliases & Classifications for Botulism

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 37MESH via Orphanet, 27ICD10 via Orphanet, 26ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

50
botulism:
Prevalence: <1/1000000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

botulism 9 44 11 46 50 35
foodborne botulism 9 44
wound botulism 44 63
intoxication with clostridium botulinum toxin 9
food poisoning due to clostridium botulinum 9
infection due to clostridium botulinum 9
botulism, infantile 63
botulism poisoning 9
infant botulism 44


External Ids:

Disease Ontology9 DOID:11976
NCIt41 C84599
MeSH36 D001906
SNOMED-CT via Orphanet60 414531002, 398565003
UMLS via Orphanet64 C0006057
MESH via Orphanet37 D001906
ICD10 via Orphanet27 A05.1
ICD1026 A05.1

Related Diseases for Botulism

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Botulism:



Diseases related to botulism

Symptoms for Botulism

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50Orphanet
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Symptoms:

50 (show all 18)
  • early death/lethality
  • acute diarrhea
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • cardiac rhythm disorder/arrhythmia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • constipation
  • diplopia/double vision
  • mouth dryness/xerostomia
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • acute abdominal pain/colic
  • diaphragmatic palsy
  • cranial nerves palsy
  • acute palsy
  • elocution disorders/dysarthria/dysphonia
  • muscle weakness/flaccidity
  • asthenia/fatigue/weakness
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • pupillary anomalies/mydriasis/myosis/tonic pupil

Drugs & Therapeutics for Botulism

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Botulism

Drug clinical trials:

Search ClinicalTrials for Botulism

Search NIH Clinical Center for Botulism

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Genetic Tests for Botulism

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Anatomical Context for Botulism

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Botulism:

34
Testes, Colon, Lung, Skin, Breast, Bone, Heart, Bone marrow

FMA organs/tissues related to Botulism:

15
Neuromuscular junction

Animal Models for Botulism or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Botulism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.0NR0B1, SYT2, SNAP25, TSN, F2

Publications for Botulism

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Sources:
53PubMed
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Articles related to Botulism:

(show top 50)    (show all 669)
idTitleAuthorsYear
1
Infant botulism with prolonged faecal excretion of botulinum neurotoxin and Clostridium botulinum for 7 months. (23688392)
2014
2
Presence of Clostridium botulinum and botulinum toxin in milk and udder tissue of dairy cows with suspected botulism. (23585115)
2013
3
The workshop on animal botulism in Europe. (23971805)
2013
4
Notes from the field: botulism from drinking prison-made illicit alcohol - Arizona, 2012. (23388552)
2013
5
Investigation of serology for diagnosis of outbreaks of botulism in cattle. (21955441)
2012
6
Recurrent wound botulism among injection drug users in California. (21317399)
2011
7
Two unlinked cases of foodborne botulism in Italy at the beginning of 2010. (21811749)
2011
8
Epidemiology of foodborne botulism in Romania 1980-2009. (21495856)
2011
9
The ripe olive scare and hotel Loch Maree tragedy: Botulism under glass in the 1920's. (21563914)
2011
10
Botulism in cattle associated with poultry litter. (21685421)
2011
11
Three outbreaks of foodborne botulism caused by unsafe home canning of vegetables--Ohio and Washington, 2008 and 2009. (22186049)
2011
12
Outbreak of botulism (Clostridium botulinum type C) in wild waterfowl: Seoul, Korea. (20688704)
2010
13
Botulism, where are we now? (21171845)
2010
14
A brief history of botulism in South Africa. (19967922)
2009
15
Infant Botulism and Raised Intraocular Pressure. (19873952)
2009
16
Infant botulism. (19636165)
2009
17
Botulism and hot-smoked whitefish: a family cluster of type E botulism in France, September 2009. (19941787)
2009
18
Wound botulism from heroin skin popping. (18957182)
2008
19
Hematologic and biochemistry values for black-faced spoonbills (Platalea minor) with and recovering from botulism. (18689672)
2008
20
Infant botulism and treatment with BIG-IV (BabyBIG). (17484226)
2007
21
A case of infant botulism with a possible link to infant formula milk powder: evidence for the presence of more than one strain of Clostridium botulinum in clinical specimens and food. (16014431)
2005
22
Foodborne botulism in the Republic of Georgia. (15498162)
2004
23
Public perceptions and risk communications for botulism. (15588060)
2004
24
Infant botulism: a diagnostic and management challenge. (14671769)
2003
25
A botulism case of a 12-year-old girl caused by intestinal colonization of Clostridium botulinum type Ab. (12824692)
2003
26
Anthrax, botulism and tularemia in Italy. (12749299)
2003
27
Botulism: a laboratory investigation on biological and food samples from cases and outbreaks in Brazil (1982-2001). (12532215)
2002
28
Foodborne botulism from eating home-pickled eggs--Illinois, 1997. (10987245)
2000
29
Cardiac arrest due to succinylcholine-induced hyperkalemia in a patient with wound botulism. (10773516)
2000
30
The botulism hazard. (9163303)
1997
31
Experience with the use of an investigational F(ab')2 heptavalent botulism immune globulin of equine origin during an outbreak of type E botulism in Egypt. (8842274)
1996
32
Wound botulism--California, 1995. From the Center for Disease Control and Prevention. (8531319)
1996
33
Bovine botulism in Paraguay. (8888528)
1996
34
Foodborne botulism--Oklahoma, 1994. (7885310)
1995
35
Wound botulism--California, 1995. (7476845)
1995
36
Sequence of the gene coding for the neurotoxin of Clostridium botulinum type A associated with infant botulism: comparison with other clostridial neurotoxins. (8310180)
1993
37
Distinction between Clostridium botulinum type A strains associated with food-borne botulism and those with infant botulism in Japan in intraintestinal toxin production in infant mice and some other properties. (1905658)
1991
38
An outbreak of type A foodborne botulism in Taiwan due to commercially preserved peanuts. (3225100)
1988
39
Infant botulism. (3767793)
1986
40
Infant botulism. (2878137)
1986
41
Infant botulism: anticipating the second decade. (3522756)
1986
42
Rapid diagnosis of a case of infant botulism by enzyme immunoassay. (3895179)
1985
43
Epidemiologic study of infant botulism in Pennsylvania: Report of the Infant Botulism Study group. (3991282)
1985
44
Leads from the MMWR. Infant botulism--Massachusetts. (6716572)
1984
45
Electrodiagnosis in the evaluation of progressive hypotonia in infancy with particular reference to infant botulism. (6950120)
1982
46
Atypical toxin variant of Clostridium botulinum type B associated with infant botulism. (7037830)
1981
47
Prolonged respiratory paralysis in wound botulism. (421526)
1979
48
Infant botulism: new guise for an old disease. (83280)
1978
49
Infant botulism. Identification of Clostridium botulinum and its toxins in faeces. (62164)
1976
50
Interconversion of bacterial agents causing botulism and gas gangrene. (165441)
1975

Variations for Botulism

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Expression for genes affiliated with Botulism

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Botulism

Search GEO for disease gene expression data for Botulism.

Pathways for genes affiliated with Botulism

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 31KEGG, 5Cell Signaling Technology, 61Thomson Reuters, 54QIAGEN, 13EMD Millipore
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Pathways related to Botulism according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7SNAP25, VAMP2
29.3VAMP2, SNAP23, SNAP25
3
Show member pathways
Nicotine Activity on Dopaminergic Neurons39
9.3VAMP2, SNAP23, SNAP25
4
Show member pathways
9.3SNAP25, SNAP23, VAMP2
59.2VAMP2, NSF
6
Show member pathways
Synaptic Vesicle Pathway39
8.9SNAP25, VAMP2, NSF
78.9SNAP25, VAMP2, NSF
8
Show member pathways
8.9SNAP25, VAMP2, NSF
9
Show member pathways
8.8VAMP2, VAPA, SNAP23, SNAP25
10
Show member pathways
8.7NSF, VAMP2, SNAP25, SYT2
11
Show member pathways
8.5SNAP25, SNAP23, VAMP2, NSF

Compounds for genes affiliated with Botulism

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 52PharmGKB
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Compounds related to Botulism according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mgatp469.3NSF, SNAP25
2n-ethylmaleimide46 129.6SNAP25, SNAP23, VAMP2, NSF
3glucose468.5SNAP25, SNAP23, VAMP2, NSF
4cysteine468.3NSF, SNAP23, SNAP25, NR0B1
5cholesterol46 30 25 1211.2NSF, VAPA, SNAP23, SNAP25, NR0B1
6lipid467.8SNAP25, SNAP23, LY96, VAPA, VAMP2, NSF
7calcium46 52 25 1210.6SYT2, SNAP25, SNAP23, VAMP2, NSF, SV2C

GO Terms for genes affiliated with Botulism

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17Gene Ontology
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Cellular components related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle membraneGO:0306669.8SYT2, VAMP2
2SNARE complexGO:0312019.4SNAP25, VAMP2
3synaptic vesicle membraneGO:0306729.3SYT2, VAMP2, SV2C
4neuron projectionGO:0430059.2VAMP2, SNAP23, SNAP25
5cell junctionGO:0300548.6SYT2, SNAP25, SNAP23, VAMP2, SV2C
6plasma membraneGO:0058866.9F2, HCFC2, NSF, VAMP2, VAPA, LY96

Biological processes related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate secretionGO:0140479.7VAMP2, SNAP25
2neurotransmitter secretionGO:0072699.6SYT2, SNAP25, VAMP2
3membrane fusionGO:0610259.4SNAP23, VAPA
4post-Golgi vesicle-mediated transportGO:0068929.3SNAP23, VAMP2
5exocytosisGO:0068879.2SNAP23, NSF
6synaptic transmissionGO:0072688.7SYT2, SNAP25, VAMP2, NSF

Molecular functions related to Botulism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1syntaxin bindingGO:0199059.2VAMP2, NSF
2protein bindingGO:0055155.9NR0B1, F2, FBXW2, TSN, NSF, VAMP2

Products for genes affiliated with Botulism

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Botulism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet