MCID: BTL001
MIFTS: 52

Botulism malady

Categories: Rare diseases, Infectious diseases, Neuronal diseases, Muscle diseases

Aliases & Classifications for Botulism

About this section
Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 48Novoseek, 36MedlinePlus, 2CDC, 37MeSH, 66UMLS, 28ICD10, 43NCIt, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Botulism:

Name: Botulism 11 46 13 52 48 36 2 37
Foodborne Botulism 11 46
Wound Botulism 46 66
Intoxication with Clostridium Botulinum Toxin 11
Food Poisoning Due to Clostridium Botulinum 11
 
Infection Due to Clostridium Botulinum 11
Botulism, Infantile 66
Botulism Poisoning 11
Infant Botulism 46

Characteristics:

Orphanet epidemiological data:

52
botulism:
Prevalence: <1/1000000 (Europe),<1/1000000 (Worldwide),1-9/1000000 (France),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology11 DOID:11976
ICD1028 A05.1
MeSH37 D001906
NCIt43 C84599
Orphanet52 ORPHA1267
ICD10 via Orphanet29 A05.1
MESH via Orphanet38 D001906
UMLS via Orphanet67 C0006057

Summaries for Botulism

About this section
MedlinePlus:36 Botulism is a rare but serious illness. the cause is a toxin (poison) made by a bacterium called clostridium botulinum. it occurs naturally in soil. there are several kinds of botulism. foodborne botulism comes from eating foods contaminated with the toxin. wound botulism happens when a wound infected with the bacteria makes the toxin. it is more common in heroin users. infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. all forms can be deadly and are medical emergencies. symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. treatment may include antitoxins, intensive medical care, or surgery of infected wounds. to prevent botulism: be very careful when canning foods at home do not let babies eat honey get prompt medical care for infected wounds centers for disease control and prevention

MalaCards based summary: Botulism, also known as foodborne botulism, is related to infant botulism and wound botulism, and has symptoms including xerostomia, abnormality of the pupil and diplopia. An important gene associated with Botulism is SYT2 (Synaptotagmin 2), and among its related pathways are N-Glycan biosynthesis and Neuroscience. Affiliated tissues include neuromuscular junction, testes and colon, and related mouse phenotype normal.

Disease Ontology:11 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (bonta, b, e and f) located in neuromuscular junction, resulting in descending muscle paralysis, has material basis in clostridium botulinum a, has material basis in clostridium botulinum b, has material basis in clostridium botulinum e and has material basis in clostridium botulinum f.

Wikipedia:69 Botulism is a rare and potentially fatal illness caused by a toxin, produced by the bacterium... more...

Related Diseases for Botulism

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Graphical network of the top 20 diseases related to Botulism:



Diseases related to botulism

Symptoms for Botulism

About this section

Symptoms:

 52 (show all 18)
  • urinary retention
  • xerostomia
  • diplopia
  • dysarthria
  • diarrhea
  • dysphagia
  • nausea and vomiting
  • constipation
  • abdominal pain
  • respiratory insufficiency
  • diaphragmatic paralysis
  • cranial nerve paralysis
  • muscle flaccidity
  • mydriasis
  • arrhythmia
  • cerebral palsy
  • diaphragmatic weakness
  • fatigue

HPO human phenotypes related to Botulism:

(show all 15)
id Description Frequency HPO Source Accession
1 xerostomia hallmark (90%) HP:0000217
2 abnormality of the pupil hallmark (90%) HP:0000615
3 diplopia hallmark (90%) HP:0000651
4 abdominal pain hallmark (90%) HP:0002027
5 neurological speech impairment hallmark (90%) HP:0002167
6 diaphragmatic paralysis hallmark (90%) HP:0006597
7 cranial nerve paralysis hallmark (90%) HP:0006824
8 feeding difficulties in infancy hallmark (90%) HP:0008872
9 cerebral palsy hallmark (90%) HP:0100021
10 nausea and vomiting typical (50%) HP:0002017
11 constipation typical (50%) HP:0002019
12 respiratory insufficiency typical (50%) HP:0002093
13 arrhythmia typical (50%) HP:0011675
14 abnormal renal physiology typical (50%) HP:0012211
15 diarrhea occasional (7.5%) HP:0002014

Drugs & Therapeutics for Botulism

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Drugs for Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1triamcinolone acetonidePhase 4463
2
AcetylcholinePhase 4, Phase 175251-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
3
TriamcinolonePhase 4463124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
 
MLS000028542
MLS001066543
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Triatex
Tricortale
Triderm
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
4
LidocainePhase 41168137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
5glucocorticoidsPhase 44756
6
4-AminopyridinePhase 2, Phase 367504-24-51727
Synonyms:
.gamma.-Aminopyridine
275875_ALDRICH
36687_FLUKA
36687_RIEDEL
4 AP
4 Aminopyridine
4 Aminopyridine Sustained Release
4-AP
4-Aminopyridine
4-Aminopyridine 10
4-Aminopyridine Sustained Release
4-Pyridinamine
4-Pyridylamine
4-aminopyridine
5-22-09-00106 (Beilstein Handbook Reference)
504-24-5
A 0152
A0414
A78403_ALDRICH
AB1004971
AC-907/25014071
AC1L1C3R
AC1Q52BM
AI3-52547
AKOS000119896
Amaya
Amino-4 pyridine
Amino-4-Pyridine
Ampydin
Ampyra
Avitrol
Avitrol 200
BB_SC-6974
BRN 0105782
BSPBio_001562
Bio1_000353
Bio1_000842
Bio1_001331
Bio2_000282
Bio2_000762
C13728
C5H6N2
CHEBI:34385
CHEMBL284348
CID1727
Caswell No. 038
Compound 1861
D015761
D04127
Dalfampridine
DivK1c_000572
EINECS 207-987-9
EL-970
EPA Pesticide Chemical Code 069201
EU-0100032
FT-0083754
Fampridina
Fampridine
Fampridine (USAN/INN)
Fampridine SR
Fampridine [USAN:INN]
Fampridine-PR
Fampridine-SR
Fampridinum
HC150041
HMS1361O04
HMS1791O04
HMS1921H15
HMS1989O04
HMS2092F05
HMS501M14
HSDB 6037
IDI1_000572
IDI1_034032
InChI=1/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7
KBio1_000572
 
KBio2_000282
KBio2_000635
KBio2_002850
KBio2_003203
KBio2_005418
KBio2_005771
KBio3_000563
KBio3_000564
KBio3_001888
KBioGR_000282
KBioGR_001505
KBioSS_000282
KBioSS_000635
LS-130202
Lopac-A-0152
Lopac0_000032
MLS000069400
Mi-W-3
MolPort-000-146-022
N07XX07
NCGC00015009-01
NCGC00015009-03
NCGC00015009-12
NCGC00024890-01
NCGC00024890-02
NCGC00024890-03
NCGC00024890-04
NCGC00024890-05
NCGC00024890-06
NCGC00024890-07
NCGC00024890-08
NCGC00024890-09
NCGC00024890-10
NINDS_000572
NSC 15041
NSC15041
Neurelan
Neurelan (TN)
P-Aminopyridine
PYRIDINE,4-AMINO
Philips 1861
Phillips 1861
Pimadin (free base)
Prc 1237
Pymadin
Pymadine
RCRA waste no. P008
SDCCGMLS-0066228.P001
SMR000058211
SPBio_001486
SPECTRUM1501130
STK298717
Spectrum2_001413
Spectrum3_000914
Spectrum4_001013
Spectrum5_001501
Spectrum_000155
Sustained Release, 4-Aminopyridine
TL8003344
Tocris-0940
UNII-BH3B64OKL9
UPCMLD-DP125
UPCMLD-DP125:001
VMI 10-3
VMI 103
VMI-10-3
VMI-103
VMI103
WLN: T6NJ DZ
[J.Pharmacol.Exp.Ther. 275:864 (1995)]
gamma-Aminopyridine
nchem.892-comp4
p-Aminopyridine
p-Aminopyridine [UN2671] [Poison]
p-Aminopyridine [UN2671] [Poison]
pyridin-4-amine
pyridin-4-ylamine
7
Aluminum hydroxidePhase 219421645-51-2
Synonyms:
Al(OH)3
Aluminium hydroxide
Aluminium hydroxide gel, dried
 
Aluminium hydroxide, dried
Aluminum hydroxide gel, dried
Aluminum hydroxide, dried
Dried aluminium hydroxide
Dried aluminum hydroxide gel

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Botulism Outbreak in Thailand (Episode II)CompletedNCT00348426Phase 4
2Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb JointCompletedNCT01045694Phase 4
3Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.CompletedNCT00320281Phase 4
4BT-011 Pharmacokinetics of Botulism Antitoxin Heptavalent in Pediatric PatientsEnrolling by invitationNCT02051062Phase 4
5Pilot Study on the Usefulness of 3,4-diaminopyridine in the Treatment of BotulismCompletedNCT01441557Phase 2, Phase 3
6Phase 3, Randomized, Safety, Lot Consistency and Clinical Benefit Study of Recombinant Botulinum Vaccine A/BSuspendedNCT01940315Phase 3
7Safety, Tolerability, and Immunogenicity Study of Investigational Recombinant Botulinum Vaccine A/B (rBV A/B) in Volunteers Previously Immunized With Investigational Pentavalent Botulinum ToxoidCompletedNCT01701999Phase 2
8Double Blind, Safety and Immunogenicity Study of Recombinant Botulinum Vaccine A/BCompletedNCT00764634Phase 2
9Botulism Antitoxin Effects on Paralysis Induced by Botulinum Neurotoxins in the EDB MuscleCompletedNCT00636519Phase 1
10Phase 1 PK Study of XOMA 3ABCompletedNCT01357213Phase 1
11Safety Study of 7 Botulinum Antitoxin Serotypes Derived From HorsesCompletedNCT00360737Phase 1
12Phase I, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of NTM-1632RecruitingNCT02779140Phase 1
13Evaluation of the Improvement of Quality of Life of Patients Suffering From Hailey Hailey or Darier Disease After Injections of Botulism Toxin Into Large Folds.Active, not recruitingNCT02782702Phase 1
14Study of Human Botulism Immunoglobulin in Infants With BotulismCompletedNCT00004401
15Treatment of Survivors After Botulism OutbreakCompletedNCT00314080
16Effect of Agave Syrup, Placebo, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Infants/Toddlers and Their ParentsCompletedNCT01721395
17Botulinum Toxin for the Treatment of Involuntary Movement DisordersRecruitingNCT00001208
18BT-010 Registry for the Evaluation of Safety and Clinical Outcomes in Patients Treated With Botulinum AntitoxinEnrolling by invitationNCT02055183

Search NIH Clinical Center for Botulism


Cochrane evidence based reviews: botulism

Genetic Tests for Botulism

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Anatomical Context for Botulism

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MalaCards organs/tissues related to Botulism:

34
Testes, Colon, Spinal cord, Skin, Breast, Bone, Liver

FMA organs/tissues related to Botulism:

17
Neuromuscular junction

Animal Models for Botulism or affiliated genes

About this section

MGI Mouse Phenotypes related to Botulism:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.3DPAGT1, SV2A, SV2B, SYT1, SYT2

Publications for Botulism

About this section

Articles related to Botulism:

(show top 50)    (show all 758)
idTitleAuthorsYear
1
Stimulated jitter in infant botulism. (26096260)
2015
2
Regional variations in home canning practices and the risk of foodborne botulism in the republic of georgia, 2003. (25836400)
2015
3
An atypical outbreak of food-borne botulism due to Clostridium botulinum types B and E from ham. (25428161)
2015
4
Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry. (26420800)
2015
5
Outcome of Adult Horses with Botulism Treated at a Veterinary Hospital: 92 Cases (1989-2013). (25408202)
2014
6
New insight in the epidemiology of avian botulism outbreaks: necrophagous flies as vectors of Clostridium botulinum type C/D. (25079304)
2014
7
Outbreak of type E foodborne botulism linked to traditionally prepared salted fish in Ontario, Canada. (25188279)
2014
8
Production of recombinant botulism antigens: a review of expression systems. (24930432)
2014
9
Presence of Clostridium botulinum and botulinum toxin in milk and udder tissue of dairy cows with suspected botulism. (23585115)
2013
10
Notes from the field: botulism from drinking prison-made illicit alcohol - Arizona, 2012. (23388552)
2013
11
Infant botulism: first two confirmed cases in Slovenia and literature review. (23707631)
2013
12
An outbreak of foodborne botulism in Surat Thani Province, Thailand, 2012. (23883854)
2013
13
3,4-Diaminopyridine may improve neuromuscular block during botulism. (24007658)
2013
14
Foodborne botulism in Poland in 2111. (24040723)
2013
15
Asymmetric type F botulism with cranial nerve demyelination. (22257488)
2012
16
Two unlinked cases of foodborne botulism in Italy at the beginning of 2010. (21811749)
2011
17
Epidemiology of foodborne botulism in Romania 1980-2009. (21495856)
2011
18
The ripe olive scare and hotel Loch Maree tragedy: Botulism under glass in the 1920's. (21563914)
2011
19
Botulism in cattle associated with poultry litter. (21685421)
2011
20
Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism. (21832053)
2011
21
In vivo molecular imaging analysis of a nasal vaccine that induces protective immunity against botulism in nonhuman primates. (20881188)
2010
22
Botulism and hot-smoked whitefish: a family cluster of type E botulism in France, September 2009. (19941787)
2009
23
Electrophysiological diagnosis and patterns of response to treatment of botulism with neuromuscular respiratory failure. (19609915)
2009
24
Hematologic and biochemistry values for black-faced spoonbills (Platalea minor) with and recovering from botulism. (18689672)
2008
25
Botulism: a rare complication of injecting drug use. (18156552)
2008
26
Infant botulism and treatment with BIG-IV (BabyBIG). (17484226)
2007
27
Alternative vaccination against equine botulism (BoNT/C). (18065309)
2007
28
Foodborne botulism in the Republic of Georgia. (15498162)
2004
29
Botulism: update and review. (15257512)
2004
30
Anthrax, botulism and tularemia in Italy. (12749299)
2003
31
Outbreak of botulism type E associated with eating a beached whale--Western Alaska, July 2002. (12608715)
2003
32
Food-borne botulism cases in Van region in eastern Turkey: importance of electromyography in the diagnosis. (14535050)
2003
33
Botulism: a laboratory investigation on biological and food samples from cases and outbreaks in Brazil (1982-2001). (12532215)
2002
34
Infantile botulism: an atypical case of an uncommon disease. (10224186)
1999
35
Botulism in chickens associated with elevated iron levels. (10611996)
1999
36
An outbreak of food-borne botulism. (10457885)
1999
37
Wound botulism--California, 1995. From the Center for Disease Control and Prevention. (8531319)
1996
38
Wound botulism--California, 1995. (7476845)
1995
39
Preventing complications in infant botulism. (7889803)
1995
40
Sequence of the gene coding for the neurotoxin of Clostridium botulinum type A associated with infant botulism: comparison with other clostridial neurotoxins. (8310180)
1993
41
Distinction between Clostridium botulinum type A strains associated with food-borne botulism and those with infant botulism in Japan in intraintestinal toxin production in infant mice and some other properties. (1905658)
1991
42
An outbreak of type A foodborne botulism in Taiwan due to commercially preserved peanuts. (3225100)
1988
43
Infant botulism: anticipating the second decade. (3522756)
1986
44
Wound botulism associated with a positive tensilon test. (6636734)
1983
45
Electrodiagnosis in the evaluation of progressive hypotonia in infancy with particular reference to infant botulism. (6950120)
1982
46
Wound botulism associated with parenteral cocaine abuse--New York City. (6801464)
1982
47
Atypical toxin variant of Clostridium botulinum type B associated with infant botulism. (7037830)
1981
48
Wound botulism. (7463544)
1981
49
Infant botulism. (386749)
1979
50
Infant botulism in Australia. (723716)
1978

Variations for Botulism

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Expression for genes affiliated with Botulism

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Search GEO for disease gene expression data for Botulism.

GO Terms for genes affiliated with Botulism

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Cellular components related to Botulism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chromaffin granule membraneGO:004258410.1SYT1, SYT2
2SNARE complexGO:00312019.5SYT1, VAMP1
3terminal boutonGO:00431959.1SV2A, SYT1, VAMP1
4synaptic vesicleGO:00080219.1SV2A, SV2B, SYT1
5cell junctionGO:00300548.7SV2B, SYT1, SYT2, VAMP1
6synaptic vesicle membraneGO:00306727.9SV2A, SV2B, SYT1, SYT2, VAMP1

Biological processes related to Botulism according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of dendrite extensionGO:190386110.0SYT1, SYT2
2protein N-linked glycosylationGO:000648710.0DPAGT1, TUSC3
3synaptic vesicle endocytosisGO:00484889.9SYT1, SYT2
4neurotransmitter transportGO:00068369.7SV2A, SV2B
5regulation of calcium ion-dependent exocytosisGO:00171589.7SYT1, SYT2
6calcium ion-regulated exocytosis of neurotransmitterGO:00487919.4SYT1, SYT2
7transmembrane transportGO:00550859.3SV2A, SV2B, TUSC3
8vesicle fusionGO:00069069.2SYT1, SYT2, VAMP1

Molecular functions related to Botulism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1SNARE bindingGO:00001499.9SYT1, VAMP1
2transmembrane transporter activityGO:00228579.8SV2A, SV2B
3syntaxin bindingGO:00199059.7SYT1, SYT2
4clathrin bindingGO:00302769.6SYT1, SYT2
5calcium-dependent phospholipid bindingGO:00055449.4SYT1, SYT2

Sources for Botulism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet