MCID: BTL001
MIFTS: 50

Botulism malady

Categories: Rare diseases, Infectious diseases, Neuronal diseases, Muscle diseases

Aliases & Classifications for Botulism

About this section
Sources:
10Disease Ontology, 45NIH Rare Diseases, 65UMLS, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 35MedlinePlus, 2CDC, 27ICD10, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Botulism:

Name: Botulism 10 45 47 12 51 36 35 2
Foodborne Botulism 10 45
Wound Botulism 45 65
Intoxication with Clostridium Botulinum Toxin 10
Food Poisoning Due to Clostridium Botulinum 10
 
Infection Due to Clostridium Botulinum 10
Botulism, Infantile 65
Botulism Poisoning 10
Infant Botulism 45

Characteristics:

Orphanet epidemiological data:

51
botulism:
Prevalence: <1/1000000 (Europe),<1/1000000 (Worldwide),1-9/1000000 (France),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology10 DOID:11976
ICD1027 A05.1
MeSH36 D001906
NCIt42 C84599
Orphanet51 1267
ICD10 via Orphanet28 A05.1
MESH via Orphanet37 D001906
UMLS via Orphanet66 C0006057
UMLS65 C0006057, C0238027, C1306794

Summaries for Botulism

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MedlinePlus:35 Botulism is a rare but serious illness. the cause is a toxin (poison) made by a bacterium called clostridium botulinum. it occurs naturally in soil. there are several kinds of botulism. foodborne botulism comes from eating foods contaminated with the toxin. wound botulism happens when a wound infected with the bacteria makes the toxin. it is more common in heroin users. infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. all forms can be deadly and are medical emergencies. symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. treatment may include antitoxins, intensive medical care, or surgery of infected wounds. to prevent botulism: be very careful when canning foods at home do not let babies eat honey get prompt medical care for infected wounds centers for disease control and prevention

MalaCards based summary: Botulism, also known as foodborne botulism, is related to wound botulism and infant botulism, and has symptoms including xerostomia, abnormality of the pupil and diplopia. An important gene associated with Botulism is SNAP25 (Synaptosome Associated Protein 25kDa), and among its related pathways are N-Glycan biosynthesis and Delta508-CFTR traffic / Sorting endosome formation in CF. Affiliated tissues include neuromuscular junction, breast and lung, and related mouse phenotype normal.

Disease Ontology:10 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located in neuromuscular junction, resulting in descending muscle paralysis, has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F.

Wikipedia:68 Botulism (Latin, botulus, a sausage) is a rare and potentially fatal illness caused by a toxin produced... more...

Related Diseases for Botulism

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Graphical network of the top 20 diseases related to Botulism:



Diseases related to botulism

Symptoms for Botulism

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Symptoms:

 51 (show all 18)
  • pupillary anomalies/mydriasis/myosis/tonic pupil
  • diplopia/double vision
  • mouth dryness/xerostomia
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • acute abdominal pain/colic
  • diaphragmatic palsy
  • cranial nerves palsy
  • acute palsy
  • elocution disorders/dysarthria/dysphonia
  • muscle weakness/flaccidity
  • asthenia/fatigue/weakness
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • constipation
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cardiac rhythm disorder/arrhythmia
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • acute diarrhea
  • early death/lethality

HPO human phenotypes related to Botulism:

(show all 15)
id Description Frequency HPO Source Accession
1 xerostomia hallmark (90%) HP:0000217
2 abnormality of the pupil hallmark (90%) HP:0000615
3 diplopia hallmark (90%) HP:0000651
4 abdominal pain hallmark (90%) HP:0002027
5 neurological speech impairment hallmark (90%) HP:0002167
6 diaphragmatic paralysis hallmark (90%) HP:0006597
7 cranial nerve paralysis hallmark (90%) HP:0006824
8 feeding difficulties in infancy hallmark (90%) HP:0008872
9 cerebral palsy hallmark (90%) HP:0100021
10 nausea and vomiting typical (50%) HP:0002017
11 constipation typical (50%) HP:0002019
12 respiratory insufficiency typical (50%) HP:0002093
13 arrhythmia typical (50%) HP:0011675
14 abnormal renal physiology typical (50%) HP:0012211
15 diarrhea occasional (7.5%) HP:0002014

Drugs & Therapeutics for Botulism

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Drugs for Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
LidocaineapprovedPhase 41103137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Afterburn
Akten
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bikini Zone Medicated
Bikini Zone Medicated Creme
Bio-0767
Bio-scriptives Lidum
Bio-scriptives Lidum Hemorroidal (anorectal)
Bio-scriptives Lidum Topical Analgesic
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
Burn Relief Leader
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Comfortcaine
Cuivasil
Curacaine Transdermal Corporation
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
Derma Numb
DermaFlex
Desert Harvest Releveum
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Dr. Numb
Dr. Richs Numbing
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gigi Anesthetic Numbing
Gravocain
H-releve Hemorrhoidal
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
Hawaiian Tropic
Hush Anesthetic
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
LS-805
Lanabiotic
 
Laryng-o-jet
Leostesin
Lida-Mantle
Lidall
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine 4% Cream
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Hydrochloride
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocaine hydrochloride
Lidocainum
Lidocainum [INN-Latin]
Lidocare Mist
Lidocaton
Lidocream 4
Lidocream 5
Lidoderm
Lidoderm 5
Lidoject-1
Lidoject-2
Lifestyles Epic Male Genital Desensitizer
Lignocaine
Lignocainum
Lingocaine
Lmx4
Lmx5
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Numb Master Topical Anesthetic
Numb Nuts
Ocean Potion Instant Burn Relief Ice
Octocaine
Octocaine-100
Octocaine-50
Plum Smooth Plumb Numb Gelee
Premjact Male Desensitizer Pound International
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Recticare
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Simplicity Desensitizing
Simply Numb Endure
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Sole Serum
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Walgreens Aloe Vera Pain Relieving
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocaine-mpf
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zcaine Fast Acting Anesthetic
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
2
TriamcinoloneapprovedPhase 4448124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Allernaze
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
MLS000028542
MLS001066543
 
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone Acetonide
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Trianex
Triatex
Tricortale
Triderm
Triesence
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
3
AcetylcholineexperimentalPhase 468951-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
Miochol E
O-Acetylcholine
acetylcholine chloride
4Neuromuscular AgentsPhase 4922
5Neurotransmitter AgentsPhase 414795
6Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 49988
7Immunosuppressive AgentsPhase 410422
8OnabotulinumtoxinAPhase 4588
9AntitoxinsPhase 4, Phase 111
10Pharmaceutical SolutionsPhase 47004
11Triamcinolone diacetatePhase 4448
12Triamcinolone hexacetonidePhase 4448
13triamcinolone acetonidePhase 4448
14Sodium Channel BlockersPhase 41180
15HormonesPhase 411748
16Peripheral Nervous System AgentsPhase 418510
17IncobotulinumtoxinAPhase 4599
18Anesthetics, LocalPhase 42347
19Anti-Arrhythmia AgentsPhase 42371
20Hormone AntagonistsPhase 410002
21AbobotulinumtoxinAPhase 4588
22Botulinum AntitoxinPhase 4, Phase 16
23Immunologic FactorsPhase 4, Phase 2, Phase 118483
24Anti-Inflammatory AgentsPhase 48478
25AnestheticsPhase 47385
26glucocorticoidsPhase 43896
27Botulinum ToxinsPhase 4616
28Diuretics, Potassium SparingPhase 41445
29Cholinergic AgentsPhase 43243
30Botulinum Toxins, Type APhase 4588
31Central Nervous System DepressantsPhase 410016
32
DalfampridineapprovedPhase 2, Phase 362504-24-51727
Synonyms:
.gamma.-Aminopyridine
275875_ALDRICH
36687_FLUKA
36687_RIEDEL
4 AP
4 Aminopyridine
4 Aminopyridine Sustained Release
4-AP
4-Aminopyridine
4-Aminopyridine 10
4-Aminopyridine Sustained Release
4-Pyridinamine
4-Pyridylamine
4-aminopyridine
5-22-09-00106 (Beilstein Handbook Reference)
504-24-5
A 0152
A0414
A78403_ALDRICH
AB1004971
AC-907/25014071
AC1L1C3R
AC1Q52BM
AI3-52547
AKOS000119896
Amaya
Amino-4 pyridine
Amino-4-Pyridine
Ampydin
Ampyra
Avitrol
Avitrol 200
BB_SC-6974
BRN 0105782
BSPBio_001562
Bio1_000353
Bio1_000842
Bio1_001331
Bio2_000282
Bio2_000762
C13728
C5H6N2
CHEBI:34385
CHEMBL284348
CID1727
Caswell No. 038
Compound 1861
D015761
D04127
Dalfampridine
DivK1c_000572
EINECS 207-987-9
EL-970
EPA Pesticide Chemical Code 069201
EU-0100032
FT-0083754
Fampridina
Fampridine
Fampridine (USAN/INN)
Fampridine SR
Fampridine [USAN:INN]
Fampridine-PR
Fampridine-SR
Fampridinum
Fampyra
HC150041
HMS1361O04
HMS1791O04
HMS1921H15
HMS1989O04
HMS2092F05
HMS501M14
HSDB 6037
IDI1_000572
IDI1_034032
InChI=1/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7
 
KBio1_000572
KBio2_000282
KBio2_000635
KBio2_002850
KBio2_003203
KBio2_005418
KBio2_005771
KBio3_000563
KBio3_000564
KBio3_001888
KBioGR_000282
KBioGR_001505
KBioSS_000282
KBioSS_000635
LS-130202
Lopac-A-0152
Lopac0_000032
MLS000069400
Mi-W-3
MolPort-000-146-022
N07XX07
NCGC00015009-01
NCGC00015009-03
NCGC00015009-12
NCGC00024890-01
NCGC00024890-02
NCGC00024890-03
NCGC00024890-04
NCGC00024890-05
NCGC00024890-06
NCGC00024890-07
NCGC00024890-08
NCGC00024890-09
NCGC00024890-10
NINDS_000572
NSC 15041
NSC15041
Neurelan
Neurelan (TN)
P-Aminopyridine
PYRIDINE,4-AMINO
Philips 1861
Phillips 1861
Pimadin (free base)
Prc 1237
Pymadin
Pymadine
RCRA waste no. P008
SDCCGMLS-0066228.P001
SMR000058211
SPBio_001486
SPECTRUM1501130
STK298717
Spectrum2_001413
Spectrum3_000914
Spectrum4_001013
Spectrum5_001501
Spectrum_000155
Sustained Release, 4-Aminopyridine
TL8003344
Tocris-0940
UNII-BH3B64OKL9
UPCMLD-DP125
UPCMLD-DP125:001
VMI 10-3
VMI 103
VMI-10-3
VMI-103
VMI103
WLN: T6NJ DZ
[J.Pharmacol.Exp.Ther. 275:864 (1995)]
gamma-Aminopyridine
nchem.892-comp4
p-Aminopyridine
p-Aminopyridine [UN2671] [Poison]
p-Aminopyridine [UN2671] [Poison]
pyridin-4-amine
pyridin-4-ylamine
33VaccinesPhase 3, Phase 2, Phase 16085
343,4-diaminopyridinePhase 2, Phase 319
35Potassium Channel BlockersPhase 2, Phase 3151
36
Aluminum hydroxideapprovedPhase 2178
Synonyms:
Al(OH)3
Aluminiumhydroxid
 
Aluminum Hydroxide
Aluminum hydroxide
Dermadrox
37ImmunoglobulinsPhase 2, Phase 14477
38AntibodiesPhase 2, Phase 14477
39Antibodies, MonoclonalPhase 12413

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Botulism Outbreak in Thailand (Episode II)CompletedNCT00348426Phase 4
2Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb JointCompletedNCT01045694Phase 4
3Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.CompletedNCT00320281Phase 4
4BT-011 Pharmacokinetics of Botulism Antitoxin Heptavalent in Pediatric PatientsEnrolling by invitationNCT02051062Phase 4
5Pilot Study on the Usefulness of 3,4-diaminopyridine in the Treatment of BotulismCompletedNCT01441557Phase 2, Phase 3
6Phase 3, Randomized, Safety, Lot Consistency and Clinical Benefit Study of Recombinant Botulinum Vaccine A/BSuspendedNCT01940315Phase 3
7Safety, Tolerability, and Immunogenicity Study of Investigational Recombinant Botulinum Vaccine A/B (rBV A/B) in Volunteers Previously Immunized With Investigational Pentavalent Botulinum ToxoidCompletedNCT01701999Phase 2
8Double Blind, Safety and Immunogenicity Study of Recombinant Botulinum Vaccine A/BCompletedNCT00764634Phase 2
9Botulism Antitoxin Effects on Paralysis Induced by Botulinum Neurotoxins in the EDB MuscleCompletedNCT00636519Phase 1
10Phase 1 PK Study of XOMA 3ABCompletedNCT01357213Phase 1
11Safety Study of 7 Botulinum Antitoxin Serotypes Derived From HorsesCompletedNCT00360737Phase 1
12Evaluation of the Improvement of Quality of Life of Patients Suffering From Hailey Hailey or Darier Disease After Injections of Botulism Toxin Into Large Folds.Active, not recruitingNCT02782702Phase 1
13Phase I, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of NTM-1632Not yet recruitingNCT02779140Phase 1
14Study of Human Botulism Immunoglobulin in Infants With BotulismCompletedNCT00004401
15Treatment of Survivors After Botulism OutbreakCompletedNCT00314080
16Effect of Agave Syrup, Placebo, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Infants/Toddlers and Their ParentsCompletedNCT01721395
17Botulinum Toxin for the Treatment of Involuntary Movement DisordersRecruitingNCT00001208
18BT-010 Registry for the Evaluation of Safety and Clinical Outcomes in Patients Treated With Botulinum AntitoxinEnrolling by invitationNCT02055183

Search NIH Clinical Center for Botulism


Cochrane evidence based reviews: botulism

Genetic Tests for Botulism

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Anatomical Context for Botulism

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MalaCards organs/tissues related to Botulism:

33
Breast, Lung, Liver, Testes, Bone, Prostate, Endothelial

FMA organs/tissues related to Botulism:

16
Neuromuscular junction

Animal Models for Botulism or affiliated genes

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MGI Mouse Phenotypes related to Botulism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.3DPAGT1, SNAP25, SYT1, SYT2, VAMP2

Publications for Botulism

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Articles related to Botulism:

(show top 50)    (show all 739)
idTitleAuthorsYear
1
Serum miR-206 and miR-132 as Potential Circulating Biomarkers for Mild Cognitive Impairment. (25589731)
2015
2
High prevalence of primary focal dystonia in the Faroe Islands. (26041438)
2015
3
Statistical estimations for Plasmodium vivax malaria in South Korea. (25902156)
2015
4
Typhoid Fever in young children in bangladesh: clinical findings, antibiotic susceptibility pattern and immune responses. (25849611)
2015
5
Is there an association between a history of placental abruption and long-term maternal renal complications? (25234099)
2014
6
Frequent mutations in NOTCH1 ligand-binding regions in Japanese oral squamous cell carcinoma. (25234595)
2014
7
Miller Fisher syndrome with presynaptic neuromuscular transmission disorder. (25300589)
2014
8
Molluscum contagiosum infection on a congenital intermediate melanocytic naevus. (25183021)
2014
9
Recurrent leiomyosarcoma presenting as malignant arterial tumor thrombus. (24371672)
2013
10
Her2neu amplification associates with Co-deletion 1p/14q in recurrent meningiomas. (23603172)
2013
11
Toward magnetic resonance imaging biomarkers for progressive supranuclear palsy and multisystem atrophy. (23283652)
2012
12
Effects of speed, age, and amblyopia on the perception of motion-defined form. (21911002)
2011
13
Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes]. (20356536)
2010
14
Ligularia fischeri leaf extract suppresses proinflammatory mediators in SW982 human synovial cells. (19370536)
2009
15
Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid. (19429706)
2009
16
Evaluation of surveillance case definition in the diagnosis of leptospirosis, using the Microscopic Agglutination Test: a validation study. (19386085)
2009
17
Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. (19451442)
2009
18
Association of tumour necrosis factor alpha (TNF-alpha) polymorphisms with Graves' disease: A meta-analysis. (18472000)
2008
19
Central diabetes insipidus misdiagnosed as acute gastroenteritis in a pediatric patient. (18826743)
2008
20
Effect of two carbohydrate-modified tube-feeding formulas on metabolic responses in patients with type 2 diabetes. (18718737)
2008
21
Reticulocytes in untreated obstructive sleep apnoea. (19065844)
2008
22
Picomole-level mapping of protein disulfides by mass spectrometry following partial reduction and alkylation. (18358819)
2008
23
Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex. (17157868)
2007
24
Triptolide inhibits CCR5 expressed in synovial tissue of rat adjuvant-induced arthritis. (18195473)
2007
25
RNA aptamers selected against DNA polymerase beta inhibit the polymerase activities of DNA polymerases beta and kappa. (16707660)
2006
26
Impaired factor XIIa-dependent activation of fibrinolysis in treated antiphospholipid syndrome gestations developing late-pregnancy complications. (16458646)
2006
27
Interaction energies for the purine inhibitor roscovitine with cyclin-dependent kinase 2: correlated ab initio quantum-chemical, DFT and empirical calculations. (16575928)
2006
28
Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials. (16622436)
2006
29
Cloning, tissue expression, and regulation of beagle dog CYP4A genes. (16675513)
2006
30
Gastric mucosal cytokine levels in relation to host interleukin-1 polymorphisms and Helicobacter pyloricagA genotype. (16036505)
2005
31
Inner ear decompression sickness and mal de debarquement. (16272943)
2005
32
Anti-thrombomodulin antibodies and venous thrombosis. (15389121)
2004
33
A comparative study of prostate specific antigen (PSA), C-terminal propeptide of blood type I procollagen (PICP) and urine type I collagen-crosslinked N telopeptide (NTx) levels using bone scintigraphy in prostate cancer patients. (12932112)
2003
34
Heme oxygenase-1: unleashing the protective properties of heme. (12909459)
2003
35
Impact of short-term versus long-term topical steroids on corneal neovascularization after non-high-risk keratoplasty. (11521696)
2001
36
Magnetic resonance images of primary malignant lymphoma of the uterine body: a case report. (11155924)
2000
37
The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23. (10037797)
1999
38
Liver dihydropyrimidine dehydrogenase activity in human, cynomolgus monkey, rhesus monkey, dog, rat and mouse. (9597696)
1998
39
Acanthamoeba keratitis and contact lens wear. (9371196)
1997
40
Acute interstitial pneumonia: high-resolution CT findings correlated with pathology. (9016201)
1997
41
Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelope. (8844200)
1996
42
Spontaneous evolution and photocoagulation of diabetic cystoid macular edema. (8045437)
1994
43
Effect of omeprazole on gastric first-pass metabolism of ethanol. (1587193)
1992
44
Mitogenic effects of coagulation factor XII and factor XIIa on HepG2 cells. (1852005)
1991
45
Annular pancreas in the adult. (1113725)
1975
46
Haemodialysis in acute porphyria. (4443572)
1974
47
Hereditary sensory neuropathy, type II. Clinical, electrophysiologic, histologic, and biochemical studies of a Quebec kinship. (4351257)
1973
48
Cortisone in neurologic diseases. (15440934)
1950
49
50

Variations for Botulism

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Expression for genes affiliated with Botulism

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Search GEO for disease gene expression data for Botulism.

Pathways for genes affiliated with Botulism

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Pathways related to Botulism according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7DPAGT1, TUSC3
2
Show member pathways
9.7SNAP25, VAMP2
3
Show member pathways
9.5VAMP1, VAMP2
4
Show member pathways
9.0SNAP25, SYT1, VAMP2
5
Show member pathways
9.0SNAP25, SYT1, VAMP2
69.0SNAP25, SYT1, VAMP2
7
Show member pathways
8.9SNAP25, SNAP29, VAMP1, VAMP2
8
Show member pathways
8.4SNAP25, VAMP1, VAMP2, VAPA
9
Show member pathways
8.3SNAP25, SYT1, SYT2, VAMP1, VAMP2
10
Show member pathways
8.3SNAP25, SYT1, SYT2, VAMP1, VAMP2

GO Terms for genes affiliated with Botulism

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Cellular components related to Botulism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chromaffin granule membraneGO:004258410.1SYT1, SYT2
2synaptic vesicle membraneGO:003067210.1SYT2, VAMP1
3SNARE complexGO:00312019.8SYT1, VAMP1
4neuron projectionGO:00430059.8SNAP25, VAMP2
5clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:00612029.7SYT1, VAMP2
6synaptic vesicleGO:00080219.7SYT1, VAMP2
7cytosolGO:00058298.9SNAP25, SYT2, VAMP1, VAMP2

Biological processes related to Botulism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1calcium ion-regulated exocytosis of neurotransmitterGO:00487919.5SYT1, SYT2
2regulation of insulin secretionGO:00507969.4SNAP25, VAMP2
3neurotransmitter secretionGO:00072699.0SNAP25, SYT1, VAMP2

Molecular functions related to Botulism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phospholipid bindingGO:00055439.3SYT1, VAMP2

Sources for Botulism

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet