MCID: BTN002
MIFTS: 41

Boutonneuse Fever malady

Infectious diseases, Rare diseases categories

Aliases & Classifications for Boutonneuse Fever

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 61UMLS, 56SNOMED-CT, 27ICD9CM, 33MeSH, 62UMLS via Orphanet, 34MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Aliases & Descriptions for Boutonneuse Fever:

Name: Boutonneuse Fever 8 10 48 61
African Tick Typhus 8 48
Kenya Tick Typhus 8 48
Marseilles Fever 8 48
 
Rickettsia Conorii Spotted Fever 8
South African Tick-Bite Fever 8
African Tick Bite Fever 61
Kenya Tick-Bite Fever 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
boutonneuse fever:
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age


External Ids:

Disease Ontology8 DOID:14095
ICD9CM27 082.1
MeSH33 D001907
UMLS via Orphanet62 C0006060
MESH via Orphanet34 D001907
ICD10 via Orphanet26 A77.1

Summaries for Boutonneuse Fever

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Disease Ontology:8 A spotted fever that has material basis in rickettsia conorii subsp conorii, which is transmitted by dog tick (rhipicephalus sanguineus). the infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary: Boutonneuse Fever, also known as african tick typhus, is related to african tick-bite fever and spotted fever, and has symptoms including fever, eschar (usually single) and regional adenopathy. An important gene associated with Boutonneuse Fever is IRS4 (insulin receptor substrate 4), and among its related pathways is Adipogenesis. The compounds thiobarbituric acid and sodium azide have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and endothelial, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:64 Boutonneuse fever (also called Mediterranean spotted fever, fi more...

Related Diseases for Boutonneuse Fever

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Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1african tick-bite fever10.8
2spotted fever10.5
3typhus10.5
4siderosis10.4CP
5rocky mountain spotted fever10.3
6malaria10.2G6PD, CP
7hepatitis10.2
8polymyalgia rheumatica10.2
9glucose-6-phosphate dehydrogenase deficiency10.2
10endotheliitis10.2
11mediterranean spotted fever10.2
12wilson disease10.2G6PD, CP
13iron metabolism disease10.2G6PD, CP
14hemolytic anemia10.2G6PD, CP
15acute respiratory distress syndrome10.2CP, SERPINA1
16galactosemia10.1CP, SERPINA1
17hemochromatosis10.1CP, SERPINA1
18alcohol dependence10.1G6PD, CP
19cholestasis10.1CP, SERPINA1
20viral hepatitis10.1G6PD, SERPINA1
21pancreatitis, hereditary10.1SERPINA1, LPL
22nephrotic syndrome10.1SERPINA1, LPL
23pancreatitis10.0LPL, SERPINA1
24metabolic syndrome x10.0LPL, G6PD
25liver cirrhosis10.0SERPINA1, CP
26deficiency anemia10.0CP, G6PD, LPL
27spondyloarthropathy 110.0TLR4, SERPINA1
28colorectal cancer9.9LPL, CP, SERPINA1
29liver disease9.9SERPINA1, TLR4
30chronic lymphocytic leukemia9.9LPL, TLR4
31dementia9.9LPL, CP
32hepatitis c9.9SERPINA1, TLR4
33congenital heart disease9.8G6PD, CP, TLR4
34stroke, ischemic9.8TLR4, CP, LPL
35coronary artery disease9.8LPL, TLR4
36tuberculosis9.8CP, SERPINA1, TLR4
37hypersensitivity reaction type ii disease9.8TLR4, G6PD, LPL
38acute pancreatitis9.8TLR4, SERPINA1, LPL
39ulcerative colitis9.8LPL, SERPINA1, TLR4
40asthma9.8TLR4, SERPINA1, CP
41viral infectious disease9.7G6PD, SERPINA1, TLR4
42burkitt lymphoma9.7TLR4, SERPINA1, CP
43diabetes mellitus, insulin-dependent9.7SERPINA1, CP, G6PD, LPL
44breast cancer9.7IRS4, G6PD, CP, SERPINA1
45lung cancer9.7TLR4, SERPINA1, LPL
46atherosclerosis9.6TLR4, CP, G6PD, LPL
47cystic fibrosis9.6LPL, CP, SERPINA1, TLR4
48rheumatoid arthritis9.6LPL, CP, SERPINA1, TLR4
49melanoma9.6TLR4, SERPINA1, CP, LPL

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to boutonneuse fever

Symptoms for Boutonneuse Fever

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Symptoms:

 8
  • fever
  • eschar (usually single)
  • regional adenopathy
  • maculopapular rash on extremities

Drugs & Therapeutics for Boutonneuse Fever

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Drug clinical trials:

Search ClinicalTrials for Boutonneuse Fever

Search NIH Clinical Center for Boutonneuse Fever

Genetic Tests for Boutonneuse Fever

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Anatomical Context for Boutonneuse Fever

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MalaCards organs/tissues related to Boutonneuse Fever:

31
Liver, T cells, Endothelial

Animal Models for Boutonneuse Fever or affiliated genes

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MGI Mouse Phenotypes related to Boutonneuse Fever:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2LPL, G6PD, CP, TLR4
2MP:00053767.4LPL, IRS4, G6PD, CP, TLR4

Publications for Boutonneuse Fever

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Articles related to Boutonneuse Fever:

(show all 40)
idTitleAuthorsYear
1
Boutonneuse fever and climate variability. (17114701)
2006
2
Role of TLR4 receptor polymorphisms in Boutonneuse fever. (16388712)
2005
3
Boutonneuse fever in Portugal: 1995-2000. Data of a state laboratory. (12800955)
2003
4
Evaluation of clinical diagnosis scores for Boutonneuse fever. (12860646)
2003
5
Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii. (10886788)
2000
6
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever. (10444262)
1999
7
Clinical and laboratory findings of boutonneuse fever in Sicilian children. (9667405)
1998
8
Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. (9528898)
1998
9
Alteration of interleukin-2 (IL-2) and soluble IL-2 receptor secretion in the sera and urine of patients with rickettsial boutonneuse fever. (8985208)
1997
10
Malignant boutonneuse fever and polymyalgia rheumatica: a coincidental association? (9334871)
1997
11
Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. (8896508)
1996
12
Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. (8059165)
1994
13
High levels of interferon-gamma in boutonneuse fever. (7996014)
1994
14
Changes in plasma lipoproteins in Mediterranean boutonneuse fever]. (1347656)
1992
15
Spotless boutonneuse fever. (1520773)
1992
16
Spotless boutonneuse fever. (1571413)
1992
17
Epidemiology of boutonneuse fever in western Sicily: accidental laboratory infection with a rickettsial agent isolated from a tick. (2273984)
1990
18
A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. (2106490)
1990
19
Ofloxacin in the treatment of boutonneuse fever. A preliminary report. (16312704)
1989
20
Epidemiology of boutonneuse fever in western Sicily: demonstration of multiple spotted fever group-Rickettsiae subtypes. (2779456)
1989
21
ARDS associated with boutonneuse fever. (2924629)
1989
22
Laboratory diagnosis of boutonneuse fever by enzyme-linked immunosorbent assay. (2694514)
1989
23
Pathogenesis of rickettsial eschars: the tache noire of boutonneuse fever. (3192207)
1988
24
Boutonneuse fever transmitted by conjunctival inoculation. (3236764)
1988
25
Boutonneuse fever and Rocky Mountain spotted fever are not alike. (3588121)
1987
26
Familial cases of boutonneuse fever. (3691750)
1987
27
C-reactive protein in boutonneuse fever. (3780711)
1986
28
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). (3513550)
1986
29
Epidemiology of boutonneuse fever in western Sicily: isolation of spotted fever group Rickettsiae from Rhipicephalus sanguineus (fam. Ixodidae). (3951368)
1986
30
Boutonneuse fever in American travelers. (3941277)
1986
31
Frequent occurrence of hepatic lesions in boutonneuse fever. (2874714)
1986
32
Depletion of Hageman factor in acute phase of boutonneuse fever. (3580149)
1986
33
Subclinical infections with Boutonneuse fever in western Sicily. (4031562)
1985
34
Persistence of antibodies to Rickettsia conorii after an acute attack of boutonneuse fever. (3968457)
1985
35
A sero-epidemiological survey of asymptomatic cases of Boutonneuse fever in western Sicily. (6369650)
1984
36
Vascular permeability in boutonneuse fever. (6736678)
1984
37
The histology of "taches noires" of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. (6412440)
1983
38
Boutonneuse fever. (7065712)
1982
39
Importation into the United States from Africa of Rhipicephalus simus on a boutonneuse fever patient. (7258502)
1981
40
The liver in boutonneuse fever. (4479621)
1974

Variations for Boutonneuse Fever

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Expression for genes affiliated with Boutonneuse Fever

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Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for genes affiliated with Boutonneuse Fever

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Pathways related to Boutonneuse Fever according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5LPL, IRS4

Compounds for genes affiliated with Boutonneuse Fever

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Compounds related to Boutonneuse Fever according to GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1thiobarbituric acid449.9G6PD, CP
2sodium azide449.9CP, G6PD
3dehydroascorbic acid44 1110.9G6PD, CP
4lycopene44 2410.9CP, LPL
5ciprofloxacin44 50 1111.9CP, G6PD
6methimazole44 1 1111.8G6PD, CP
7acetone449.8G6PD, LPL
8protamine449.8LPL, CP
9starch449.8G6PD, LPL
10gemfibrozil28 44 1111.8LPL, G6PD
11hypoxanthine44 24 1111.8CP, G6PD
12glycerol 3-phosphate44 2410.7LPL, G6PD
13glibenclamide44 28 50 6012.7CP, G6PD
14alpha lipoic acid449.7G6PD, SERPINA1
15vitamin b12449.6G6PD, CP
16betacarotene449.6LPL, CP
17pioglitazone28 44 50 1112.4LPL, G6PD
18tocopherol449.4G6PD, LPL, CP
19phenobarbital44 28 50 1112.4LPL, G6PD, CP
20carnitine449.4LPL, CP, G6PD
21alpha tocopherol449.4G6PD, CP, LPL
22thyroxine44 2410.4LPL, CP, G6PD
23diphenyleneiodonium449.4G6PD, TLR4
24epinephrine44 24 1111.4LPL, G6PD, CP
25salicylic acid44 2810.3SERPINA1, G6PD
26guanidine hydrochloride449.3G6PD, LPL
27glutamine449.3CP, LPL, G6PD
28vitamin a44 24 1111.3CP, LPL, SERPINA1
29ascorbic acid44 2410.3CP, G6PD, SERPINA1
30malondialdehyde449.2G6PD, CP
31creatinine449.1SERPINA1, G6PD, CP
32adenylate449.1CP, LPL, G6PD
33carbohydrates449.1CP, LPL, TLR4
34heparin44 28 24 1112.1LPL, CP, SERPINA1
35vitamin d449.1TLR4, LPL, CP
36superoxide44 2410.0TLR4, CP, G6PD
37fibrinogen449.0SERPINA1, TLR4, CP
38aspartate448.9CP, G6PD, TLR4
39polysaccharide448.9TLR4, SERPINA1, LPL
40iron44 249.9SERPINA1, CP, TLR4
41phospholipid448.9LPL, SERPINA1, TLR4
42arachidonic acid44 28 24 1111.9SERPINA1, TLR4, LPL
43nadph44 249.9SERPINA1, TLR4, G6PD
44estrogen448.8LPL, G6PD, CP, SERPINA1
45lactate448.6CP, LPL, G6PD, TLR4
46h2o2448.5CP, SERPINA1, TLR4, G6PD
47cholesterol44 28 24 1111.5LPL, TLR4, CP, SERPINA1
48serine448.3SERPINA1, TLR4, CP, G6PD
49glucose448.0TLR4, SERPINA1, G6PD, LPL, IRS4
50lipid448.0TLR4, LPL, G6PD, CP, SERPINA1

GO Terms for genes affiliated with Boutonneuse Fever

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Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:00324969.0SERPINA1, TLR4

Sources for Boutonneuse Fever

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet