MCID: BTN002
MIFTS: 36

Boutonneuse Fever malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Boutonneuse Fever

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Sources:
10Disease Ontology, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 47Novoseek, 27ICD10, 29ICD9CM, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Boutonneuse Fever:

Name: Boutonneuse Fever 10 12 51 36 65
Mediterranean Spotted Fever 10 47
African Tick Typhus 10 51
Rickettsia Conorii Spotted Fever 10
South African Tick-Bite Fever 10
Conor and Bruch's Disease 10
Mediterranean Tick Fever 10
 
African Tick Bite Fever 65
Boutonneuse Disease 10
Kenyan Tick Typhus 10
Kenya Tick Typhus 10
Marseilles Fever 10
Kenya Fever 10

Characteristics:

Orphanet epidemiological data:

51
boutonneuse fever:
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology10 DOID:14095
ICD1027 A77.1
ICD9CM29 082.1
MeSH36 D001907
Orphanet51 83313, 101334
ICD10 via Orphanet28 A77.1
MESH via Orphanet37 D001907
UMLS via Orphanet66 C0006060
UMLS65 C0006060, C1320317

Summaries for Boutonneuse Fever

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Disease Ontology:10 A spotted fever that has material basis in Rickettsia conorii subsp conorii, which is transmitted by dog tick (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary: Boutonneuse Fever, also known as mediterranean spotted fever, is related to african tick-bite fever and spotted fever, and has symptoms including fever, eschar (usually single) and regional adenopathy. An important gene associated with Boutonneuse Fever is TLR4 (Toll Like Receptor 4), and among its related pathways are Type II interferon signaling (IFNG) and p53 Pathway (RnD). Affiliated tissues include skin, breast and prostate.

Wikipedia:68 Boutonneuse fever (also called Mediterranean spotted fever, fièvre boutonneuse, Kenya tick typhus,... more...

Related Diseases for Boutonneuse Fever

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Graphical network of diseases related to Boutonneuse Fever:



Diseases related to boutonneuse fever

Symptoms for Boutonneuse Fever

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Symptoms:

 10
  • fever
  • eschar (usually single)
  • regional adenopathy
  • maculopapular rash on extremities

Drugs & Therapeutics for Boutonneuse Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Boutonneuse Fever


Cochrane evidence based reviews: boutonneuse fever

Genetic Tests for Boutonneuse Fever

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Anatomical Context for Boutonneuse Fever

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MalaCards organs/tissues related to Boutonneuse Fever:

33
Skin, Breast, Prostate, Monocytes, Liver, Tongue, B cells

Animal Models for Boutonneuse Fever or affiliated genes

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Publications for Boutonneuse Fever

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Articles related to Boutonneuse Fever:

(show all 42)
idTitleAuthorsYear
1
Boutonneuse fever and climate variability. (17114701)
2006
2
Role of TLR4 receptor polymorphisms in Boutonneuse fever. (16388712)
2005
3
Boutonneuse fever in a child: a case report and overview. (15473280)
2004
4
Boutonneuse fever in Portugal: 1995-2000. Data of a state laboratory. (12800955)
2003
5
Evaluation of clinical diagnosis scores for Boutonneuse fever. (12860646)
2003
6
The acute phase response in Sicilian patients with boutonneuse fever admitted to hospitals in Palermo, 1992-1997. (11243751)
2001
7
Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii. (10886788)
2000
8
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever. (10444262)
1999
9
Clinical and laboratory findings of boutonneuse fever in Sicilian children. (9667405)
1998
10
Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. (9528898)
1998
11
Alteration of interleukin-2 (IL-2) and soluble IL-2 receptor secretion in the sera and urine of patients with rickettsial boutonneuse fever. (8985208)
1997
12
Malignant boutonneuse fever and polymyalgia rheumatica: a coincidental association? (9334871)
1997
13
Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. (8896508)
1996
14
Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. (8059165)
1994
15
High levels of interferon-gamma in boutonneuse fever. (7996014)
1994
16
Changes in plasma lipoproteins in Mediterranean boutonneuse fever]. (1347656)
1992
17
Spotless boutonneuse fever. (1520773)
1992
18
Spotless boutonneuse fever. (1571413)
1992
19
Epidemiology of boutonneuse fever in western Sicily: accidental laboratory infection with a rickettsial agent isolated from a tick. (2273984)
1990
20
A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. (2106490)
1990
21
Ofloxacin in the treatment of boutonneuse fever. A preliminary report. (16312704)
1989
22
Epidemiology of boutonneuse fever in western Sicily: demonstration of multiple spotted fever group-Rickettsiae subtypes. (2779456)
1989
23
ARDS associated with boutonneuse fever. (2924629)
1989
24
Laboratory diagnosis of boutonneuse fever by enzyme-linked immunosorbent assay. (2694514)
1989
25
Pathogenesis of rickettsial eschars: the tache noire of boutonneuse fever. (3192207)
1988
26
Boutonneuse fever transmitted by conjunctival inoculation. (3236764)
1988
27
Boutonneuse fever and Rocky Mountain spotted fever are not alike. (3588121)
1987
28
Familial cases of boutonneuse fever. (3691750)
1987
29
C-reactive protein in boutonneuse fever. (3780711)
1986
30
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). (3513550)
1986
31
Epidemiology of boutonneuse fever in western Sicily: isolation of spotted fever group Rickettsiae from Rhipicephalus sanguineus (fam. Ixodidae). (3951368)
1986
32
Boutonneuse fever in American travelers. (3941277)
1986
33
Frequent occurrence of hepatic lesions in boutonneuse fever. (2874714)
1986
34
Depletion of Hageman factor in acute phase of boutonneuse fever. (3580149)
1986
35
Subclinical infections with Boutonneuse fever in western Sicily. (4031562)
1985
36
Persistence of antibodies to Rickettsia conorii after an acute attack of boutonneuse fever. (3968457)
1985
37
A sero-epidemiological survey of asymptomatic cases of Boutonneuse fever in western Sicily. (6369650)
1984
38
Vascular permeability in boutonneuse fever. (6736678)
1984
39
The histology of "taches noires" of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. (6412440)
1983
40
Boutonneuse fever. (7065712)
1982
41
Importation into the United States from Africa of Rhipicephalus simus on a boutonneuse fever patient. (7258502)
1981
42
The liver in boutonneuse fever. (4479621)
1974

Variations for Boutonneuse Fever

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Expression for genes affiliated with Boutonneuse Fever

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Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for genes affiliated with Boutonneuse Fever

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Pathways related to Boutonneuse Fever according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.1IRF9, ISG15
2
Show member pathways
8.8IRF9, ISG15, TLR4

GO Terms for genes affiliated with Boutonneuse Fever

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Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:00427429.3ISG15, TLR4
2defense response to virusGO:00516079.1IRF9, ISG15

Sources for Boutonneuse Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet