MCID: BTN002
MIFTS: 47

Boutonneuse Fever malady

Infectious diseases category

Summaries for Boutonneuse Fever

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A spotted fever that has material basis in rickettsia conorii subsp conorii, which is transmitted by dog tick (rhipicephalus sanguineus). the infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards: Boutonneuse Fever, also known as african tick typhus, is related to spotted fever and typhus, and has symptoms including fever, eschar (usually single) and regional adenopathy. An important gene associated with Boutonneuse Fever is IRS4 (insulin receptor substrate 4). The compounds thiobarbituric acid and sodium azide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and t cells.

Wikipedia:63 Boutonneuse fever (also called Mediterranean spotted fever, fièvre boutonneuse, Kenya tick typhus,... more...

Aliases & Classifications for Boutonneuse Fever

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
boutonneuse fever:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

boutonneuse fever 8 10 48 60
african tick typhus 8 48
kenya tick typhus 8 48
marseilles fever 8 48
rickettsia conorii spotted fever 8
mediterranean boutonneuse fever 48
south african tick-bite fever 8
mediterranean spotted fever 48
african tick bite fever 60
kenya tick-bite fever 48


External Ids:

Disease Ontology8 DOID:14095
ICD9CM27 082.1
MeSH34 D001907
MESH via Orphanet35 D001907
ICD10 via Orphanet26 A77.1
SNOMED-CT via Orphanet57 186774005
UMLS via Orphanet61 C0006060

Related Diseases for Boutonneuse Fever

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to boutonneuse fever

Clinical Features for Boutonneuse Fever

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8Disease Ontology
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Symptoms:

8
  • fever
  • eschar (usually single)
  • regional adenopathy
  • maculopapular rash on extremities

Drugs & Therapeutics for Boutonneuse Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Boutonneuse Fever

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Anatomical Context for Boutonneuse Fever

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32MalaCards
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MalaCards organs/tissues related to Boutonneuse Fever:

32
Skin, Liver, T cells, Endothelial

Animal Models for Boutonneuse Fever or affiliated genes

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Publications for Boutonneuse Fever

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50PubMed
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Articles related to Boutonneuse Fever:

(show all 42)
idTitleAuthorsYear
1
Boutonneuse fever and climate variability. (17114701)
2006
2
Role of TLR4 receptor polymorphisms in Boutonneuse fever. (16388712)
2005
3
Boutonneuse fever in a child: a case report and overview. (15473280)
2004
4
Boutonneuse fever in Portugal: 1995-2000. Data of a state laboratory. (12800955)
2003
5
Evaluation of clinical diagnosis scores for Boutonneuse fever. (12860646)
2003
6
The acute phase response in Sicilian patients with boutonneuse fever admitted to hospitals in Palermo, 1992-1997. (11243751)
2001
7
Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii. (10886788)
2000
8
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever. (10444262)
1999
9
Clinical and laboratory findings of boutonneuse fever in Sicilian children. (9667405)
1998
10
Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. (9528898)
1998
11
Alteration of interleukin-2 (IL-2) and soluble IL-2 receptor secretion in the sera and urine of patients with rickettsial boutonneuse fever. (8985208)
1997
12
Malignant boutonneuse fever and polymyalgia rheumatica: a coincidental association? (9334871)
1997
13
Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. (8896508)
1996
14
Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. (8059165)
1994
15
High levels of interferon-gamma in boutonneuse fever. (7996014)
1994
16
Changes in plasma lipoproteins in Mediterranean boutonneuse fever]. (1347656)
1992
17
Spotless boutonneuse fever. (1520773)
1992
18
Spotless boutonneuse fever. (1571413)
1992
19
Epidemiology of boutonneuse fever in western Sicily: accidental laboratory infection with a rickettsial agent isolated from a tick. (2273984)
1990
20
A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. (2106490)
1990
21
Ofloxacin in the treatment of boutonneuse fever. A preliminary report. (16312704)
1989
22
Epidemiology of boutonneuse fever in western Sicily: demonstration of multiple spotted fever group-Rickettsiae subtypes. (2779456)
1989
23
ARDS associated with boutonneuse fever. (2924629)
1989
24
Laboratory diagnosis of boutonneuse fever by enzyme-linked immunosorbent assay. (2694514)
1989
25
Pathogenesis of rickettsial eschars: the tache noire of boutonneuse fever. (3192207)
1988
26
Boutonneuse fever transmitted by conjunctival inoculation. (3236764)
1988
27
Boutonneuse fever and Rocky Mountain spotted fever are not alike. (3588121)
1987
28
Familial cases of boutonneuse fever. (3691750)
1987
29
C-reactive protein in boutonneuse fever. (3780711)
1986
30
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). (3513550)
1986
31
Epidemiology of boutonneuse fever in western Sicily: isolation of spotted fever group Rickettsiae from Rhipicephalus sanguineus (fam. Ixodidae). (3951368)
1986
32
Boutonneuse fever in American travelers. (3941277)
1986
33
Frequent occurrence of hepatic lesions in boutonneuse fever. (2874714)
1986
34
Depletion of Hageman factor in acute phase of boutonneuse fever. (3580149)
1986
35
Subclinical infections with Boutonneuse fever in western Sicily. (4031562)
1985
36
Persistence of antibodies to Rickettsia conorii after an acute attack of boutonneuse fever. (3968457)
1985
37
A sero-epidemiological survey of asymptomatic cases of Boutonneuse fever in western Sicily. (6369650)
1984
38
Vascular permeability in boutonneuse fever. (6736678)
1984
39
The histology of "taches noires" of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. (6412440)
1983
40
Boutonneuse fever. (7065712)
1982
41
Importation into the United States from Africa of Rhipicephalus simus on a boutonneuse fever patient. (7258502)
1981
42
The liver in boutonneuse fever. (4479621)
1974

Genetic Variations for Boutonneuse Fever

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Expression for genes affiliated with Boutonneuse Fever

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Boutonneuse Fever

Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for genes affiliated with Boutonneuse Fever

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Compounds for genes affiliated with Boutonneuse Fever

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Sources:
44Novoseek, 11DrugBank, 2BitterDB, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Boutonneuse Fever according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1thiobarbituric acid4410.0CP, G6PD
2sodium azide449.9G6PD, CP
3dehydroascorbic acid44 1110.9CP, G6PD
4alpha lipoic acid449.9SERPINA1, G6PD
5alpha tocopherol449.9LPL, G6PD
6methimazole44 2 1111.8CP, G6PD
7hypoxanthine44 11 2411.8G6PD, CP
8acetone449.8LPL, G6PD
9starch449.8LPL, G6PD
10gemfibrozil44 28 1111.8LPL, G6PD
11glibenclamide44 28 49 5912.7CP, G6PD
12lycopene44 2410.7CP, LPL
13glycerol 3-phosphate44 2410.7LPL, G6PD
14protamine449.6CP, LPL
15vitamin b12449.6CP, G6PD
16salicylic acid44 2810.6SERPINA1, G6PD
17nadph44 2410.5TLR4, G6PD
18glucose449.5SERPINA1, LPL, IRS4
19ascorbic acid44 2410.5G6PD, SERPINA1, CP
20folate449.4CP, AFF2, G6PD
21tocopherol449.4CP, LPL, G6PD
22phenobarbital44 28 1111.4G6PD, LPL, CP
23carnitine449.3CP, LPL, G6PD
24guanidine hydrochloride449.3LPL, G6PD
25betacarotene449.3LPL, CP
26thyroxine44 2410.3G6PD, LPL, CP
27epinephrine44 11 2411.3G6PD, LPL, CP
28vitamin a44 11 2411.3CP, SERPINA1, LPL
29malondialdehyde449.2CP, G6PD
30glutamine449.1CP, LPL, G6PD
31fibrinogen449.0CP, SERPINA1, TLR4
32polysaccharide448.9SERPINA1, LPL, TLR4
33carbohydrates448.9CP, LPL, TLR4
34phospholipid448.9TLR4, LPL, SERPINA1
35vitamin d448.9TLR4, LPL, CP
36superoxide44 249.8CP, G6PD, TLR4
37arachidonic acid44 28 11 2411.8SERPINA1, LPL, TLR4
38iron44 249.8TLR4, SERPINA1, CP
39estrogen448.8G6PD, LPL, SERPINA1, CP
40h2o2448.7CP, SERPINA1, G6PD, TLR4
41lactate448.5TLR4, G6PD, LPL, CP
42cholesterol44 28 11 2411.4TLR4, LPL, SERPINA1, CP
43lipid448.1TLR4, G6PD, LPL, SERPINA1, CP

GO Terms for genes affiliated with Boutonneuse Fever

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Products for genes affiliated with Boutonneuse Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Boutonneuse Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet