MCID: BTN002
MIFTS: 48

Boutonneuse Fever malady

Infectious diseases, Rare diseases categories
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Summaries for Boutonneuse Fever

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Disease Ontology:8 A spotted fever that has material basis in rickettsia conorii subsp conorii, which is transmitted by dog tick (rhipicephalus sanguineus). the infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary: Boutonneuse Fever, also known as south african tick-bite fever, is related to african tick-bite fever and spotted fever, and has symptoms including An important gene associated with Boutonneuse Fever is IRS4 (insulin receptor substrate 4), and among its related pathways is Adipogenesis. The compounds thiobarbituric acid and sodium azide have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and endothelial, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:65 Boutonneuse fever (also called Mediterranean spotted fever, fi more...

Aliases & Classifications for Boutonneuse Fever

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 63UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Boutonneuse Fever, Aliases & Descriptions:

Name: Boutonneuse Fever 8 10 48 62
South African Tick-Bite Fever 8 62
African Tick Typhus 8 48
Kenya Tick Typhus 8 48
 
Marseilles Fever 8 48
Rickettsia Conorii Spotted Fever 8
African Tick Bite Fever 62
Kenya Tick-Bite Fever 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

48
boutonneuse fever:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Any age


External Ids:

Disease Ontology8 DOID:14095
MeSH34 D001907
ICD9CM27 082.1
UMLS via Orphanet63 C0006060
MESH via Orphanet35 D001907
ICD10 via Orphanet26 A77.1

Related Diseases for Boutonneuse Fever

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Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1african tick-bite fever10.9
2spotted fever10.6
3typhus10.5
4siderosis10.4CP
5rocky mountain spotted fever10.4
6malaria10.2CP, G6PD
7hepatitis10.2
8polymyalgia rheumatica10.2
9endotheliitis10.2
10mediterranean spotted fever10.2
11wilson disease10.2CP, G6PD
12iron metabolism disease10.2CP, G6PD
13hemolytic anemia10.2CP, G6PD
14adult respiratory distress syndrome10.2SERPINA1, CP
15hemochromatosis10.1CP, SERPINA1
16cholestasis10.1CP, SERPINA1
17viral hepatitis10.1SERPINA1, G6PD
18nephrotic syndrome10.1SERPINA1, LPL
19pancreatitis, chronic10.1SERPINA1, LPL
20pancreatitis10.1SERPINA1, LPL
21metabolic syndrome x10.0G6PD, LPL
22liver cirrhosis10.0SERPINA1, CP
23deficiency anemia10.0LPL, G6PD, CP
24ankylosing spondylitis10.0SERPINA1, TLR4
25colorectal cancer9.9SERPINA1, LPL, CP
26galactosemia9.9TLR4, SERPINA1
27chronic lymphocytic leukemia9.9LPL, TLR4
28dementia9.9LPL, CP
29hepatitis c9.9SERPINA1, TLR4
30congenital heart disease9.8CP, G6PD, TLR4
31cerebrovascular disease9.8TLR4, LPL, CP
32coronary artery anomaly9.8TLR4, LPL
33tuberculosis9.8CP, SERPINA1, TLR4
34hypersensitivity reaction type ii disease9.8G6PD, LPL, TLR4
35acute pancreatitis9.8SERPINA1, TLR4, LPL
36ulcerative colitis9.8LPL, TLR4, SERPINA1
37asthma9.8SERPINA1, TLR4, CP
38viral infectious disease9.8G6PD, SERPINA1, TLR4
39burkitt's lymphoma9.7SERPINA1, CP, TLR4
40diabetes mellitus9.7SERPINA1, CP, G6PD, LPL
41breast cancer9.7IRS4, SERPINA1, CP, G6PD
42lung cancer9.7SERPINA1, LPL, TLR4
43atherosclerosis9.6G6PD, LPL, TLR4, CP
44cystic fibrosis9.6CP, LPL, SERPINA1, TLR4
45rheumatoid arthritis9.6TLR4, LPL, SERPINA1, CP
46melanoma9.6TLR4, LPL, SERPINA1, CP

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to boutonneuse fever

Symptoms for Boutonneuse Fever

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Drugs & Therapeutics for Boutonneuse Fever

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Drug clinical trials:

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Search NIH Clinical Center for Boutonneuse Fever

Genetic Tests for Boutonneuse Fever

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Anatomical Context for Boutonneuse Fever

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MalaCards organs/tissues related to Boutonneuse Fever:

32
Liver, T cells, Endothelial

Animal Models for Boutonneuse Fever or affiliated genes

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MGI Mouse Phenotypes related to Boutonneuse Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2LPL, G6PD, CP, TLR4
2MP:00053767.4LPL, IRS4, G6PD, CP, TLR4

Publications for Boutonneuse Fever

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Articles related to Boutonneuse Fever:

(show all 42)
idTitleAuthorsYear
1
Boutonneuse fever and climate variability. (17114701)
2006
2
Role of TLR4 receptor polymorphisms in Boutonneuse fever. (16388712)
2005
3
Boutonneuse fever in a child: a case report and overview. (15473280)
2004
4
Boutonneuse fever in Portugal: 1995-2000. Data of a state laboratory. (12800955)
2003
5
Evaluation of clinical diagnosis scores for Boutonneuse fever. (12860646)
2003
6
The acute phase response in Sicilian patients with boutonneuse fever admitted to hospitals in Palermo, 1992-1997. (11243751)
2001
7
Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii. (10886788)
2000
8
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever. (10444262)
1999
9
Clinical and laboratory findings of boutonneuse fever in Sicilian children. (9667405)
1998
10
Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. (9528898)
1998
11
Alteration of interleukin-2 (IL-2) and soluble IL-2 receptor secretion in the sera and urine of patients with rickettsial boutonneuse fever. (8985208)
1997
12
Malignant boutonneuse fever and polymyalgia rheumatica: a coincidental association? (9334871)
1997
13
Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. (8896508)
1996
14
Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. (8059165)
1994
15
High levels of interferon-gamma in boutonneuse fever. (7996014)
1994
16
Changes in plasma lipoproteins in Mediterranean boutonneuse fever]. (1347656)
1992
17
Spotless boutonneuse fever. (1520773)
1992
18
Spotless boutonneuse fever. (1571413)
1992
19
Epidemiology of boutonneuse fever in western Sicily: accidental laboratory infection with a rickettsial agent isolated from a tick. (2273984)
1990
20
A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. (2106490)
1990
21
Ofloxacin in the treatment of boutonneuse fever. A preliminary report. (16312704)
1989
22
Epidemiology of boutonneuse fever in western Sicily: demonstration of multiple spotted fever group-Rickettsiae subtypes. (2779456)
1989
23
ARDS associated with boutonneuse fever. (2924629)
1989
24
Laboratory diagnosis of boutonneuse fever by enzyme-linked immunosorbent assay. (2694514)
1989
25
Pathogenesis of rickettsial eschars: the tache noire of boutonneuse fever. (3192207)
1988
26
Boutonneuse fever transmitted by conjunctival inoculation. (3236764)
1988
27
Boutonneuse fever and Rocky Mountain spotted fever are not alike. (3588121)
1987
28
Familial cases of boutonneuse fever. (3691750)
1987
29
C-reactive protein in boutonneuse fever. (3780711)
1986
30
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). (3513550)
1986
31
Epidemiology of boutonneuse fever in western Sicily: isolation of spotted fever group Rickettsiae from Rhipicephalus sanguineus (fam. Ixodidae). (3951368)
1986
32
Boutonneuse fever in American travelers. (3941277)
1986
33
Frequent occurrence of hepatic lesions in boutonneuse fever. (2874714)
1986
34
Depletion of Hageman factor in acute phase of boutonneuse fever. (3580149)
1986
35
Subclinical infections with Boutonneuse fever in western Sicily. (4031562)
1985
36
Persistence of antibodies to Rickettsia conorii after an acute attack of boutonneuse fever. (3968457)
1985
37
A sero-epidemiological survey of asymptomatic cases of Boutonneuse fever in western Sicily. (6369650)
1984
38
Vascular permeability in boutonneuse fever. (6736678)
1984
39
The histology of "taches noires" of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. (6412440)
1983
40
Boutonneuse fever. (7065712)
1982
41
Importation into the United States from Africa of Rhipicephalus simus on a boutonneuse fever patient. (7258502)
1981
42
The liver in boutonneuse fever. (4479621)
1974

Variations for Boutonneuse Fever

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Expression for genes affiliated with Boutonneuse Fever

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Expression patterns in normal tissues for genes affiliated with Boutonneuse Fever

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Pathways for genes affiliated with Boutonneuse Fever

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Pathways related to Boutonneuse Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5LPL, IRS4

Compounds for genes affiliated with Boutonneuse Fever

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Compounds related to Boutonneuse Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1thiobarbituric acid449.9G6PD, CP
2sodium azide449.9CP, G6PD
3dehydroascorbic acid44 1110.9G6PD, CP
4lycopene44 2410.9CP, LPL
5ciprofloxacin44 50 1111.9CP, G6PD
6methimazole44 2 1111.8G6PD, CP
7acetone449.8G6PD, LPL
8protamine449.8LPL, CP
9starch449.8G6PD, LPL
10gemfibrozil28 44 1111.8LPL, G6PD
11hypoxanthine44 24 1111.8CP, G6PD
12glycerol 3-phosphate44 2410.7LPL, G6PD
13glibenclamide44 28 50 6112.7CP, G6PD
14alpha lipoic acid449.7G6PD, SERPINA1
15vitamin b12449.6G6PD, CP
16betacarotene449.6LPL, CP
17pioglitazone28 44 50 1112.4LPL, G6PD
18tocopherol449.4G6PD, LPL, CP
19phenobarbital44 28 50 1112.4LPL, G6PD, CP
20carnitine449.4LPL, CP, G6PD
21alpha tocopherol449.4G6PD, CP, LPL
22thyroxine44 2410.4LPL, CP, G6PD
23diphenyleneiodonium449.4G6PD, TLR4
24epinephrine44 24 1111.4LPL, G6PD, CP
25salicylic acid44 2810.3SERPINA1, G6PD
26guanidine hydrochloride449.3G6PD, LPL
27glutamine449.3CP, LPL, G6PD
28vitamin a44 24 1111.3CP, LPL, SERPINA1
29ascorbic acid44 2410.3CP, G6PD, SERPINA1
30malondialdehyde449.2G6PD, CP
31creatinine449.1SERPINA1, G6PD, CP
32adenylate449.1CP, LPL, G6PD
33carbohydrates449.1CP, LPL, TLR4
34heparin44 28 24 1112.1LPL, CP, SERPINA1
35vitamin d449.1TLR4, LPL, CP
36superoxide44 2410.0TLR4, CP, G6PD
37fibrinogen449.0SERPINA1, TLR4, CP
38aspartate448.9CP, G6PD, TLR4
39polysaccharide448.9TLR4, SERPINA1, LPL
40iron44 249.9SERPINA1, CP, TLR4
41phospholipid448.9LPL, SERPINA1, TLR4
42arachidonic acid44 28 24 1111.9SERPINA1, TLR4, LPL
43nadph44 249.9SERPINA1, TLR4, G6PD
44estrogen448.8LPL, G6PD, CP, SERPINA1
45lactate448.6CP, LPL, G6PD, TLR4
46h2o2448.5CP, SERPINA1, TLR4, G6PD
47cholesterol44 28 24 1111.5LPL, TLR4, CP, SERPINA1
48serine448.3SERPINA1, TLR4, CP, G6PD
49glucose448.0TLR4, SERPINA1, G6PD, LPL, IRS4
50lipid448.0TLR4, LPL, G6PD, CP, SERPINA1

GO Terms for genes affiliated with Boutonneuse Fever

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Biological processes related to Boutonneuse Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.0SERPINA1, TLR4

Products for genes affiliated with Boutonneuse Fever

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Sources for Boutonneuse Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet