MCID: BTN002
MIFTS: 42

Boutonneuse Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Boutonneuse Fever

MalaCards integrated aliases for Boutonneuse Fever:

Name: Boutonneuse Fever 12 55 41 14 69
Mediterranean Spotted Fever 12 55 51
African Tick Typhus 12 55
Rickettsia Conorii Spotted Fever 12
South African Tick-Bite Fever 12
Conor and Bruch's Disease 12
Mediterranean Tick Fever 12
African Tick Bite Fever 69
Boutonneuse Disease 12
Kenyan Tick Typhus 12
Kenya Tick Typhus 12
Marseilles Fever 12
Kenya Fever 12

Characteristics:

Orphanet epidemiological data:

55
boutonneuse fever
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
african tick typhus
Inheritance: Not applicable;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14095
ICD10 32 A77.1
ICD9CM 34 082.1
MeSH 41 D001907
MESH via Orphanet 42 D001907
UMLS via Orphanet 70 C0006060
ICD10 via Orphanet 33 A77.1

Summaries for Boutonneuse Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia conorii subsp conorii, which is transmitted_by dog tick (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary : Boutonneuse Fever, also known as mediterranean spotted fever, is related to spotted fever and african tick-bite fever, and has symptoms including fever, eschar (usually single) and regional adenopathy. An important gene associated with Boutonneuse Fever is SELE (Selectin E), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Affiliated tissues include skin, endothelial and t cells, and related phenotypes are cardiovascular system and cellular

Wikipedia : 72 Boutonneuse fever (also called Mediterranean spotted fever, fièvre boutonneuse, Kenya tick typhus,... more...

Related Diseases for Boutonneuse Fever

Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 spotted fever 30.2 AFF2 THBD
2 african tick-bite fever 11.9
3 fascioliasis 10.3 CP SELE
4 chronic pyelonephritis 10.3 CP TLR4
5 variola major 10.3 IL2 TLR4
6 subendocardial myocardial infarction 10.2 SELE SERPINA1
7 ancylostomiasis 10.2 CP SERPINA1
8 granulosa cell tumor of the ovary 10.2 CP SERPINA1
9 epileptic encephalopathy, early infantile, 36 10.2 CP SERPINA1
10 plummer's disease 10.2 SELE SELL
11 retinitis pigmentosa 60 10.2 SELE SELL
12 phacolytic glaucoma 10.2 IL2 SERPINA1
13 bone fracture 10.2 IL2 TLR4
14 paracoccidioidomycosis 10.2 IL2 TLR4
15 leukostasis 10.1 SELE SELL
16 leukocyte adhesion deficiency, type i 10.1 SELE SELL
17 autoinflammation, lipodystrophy, and dermatosis syndrome 10.1 SELE TLR4
18 granulocytopenia 10.1 CP SELL
19 brucellosis 10.1 IL2 TLR4
20 mental retardation, x-linked, associated with fragile site fraxe 10.1 AFF2 SERPINA1
21 filariasis 10.1 IL2 TLR4
22 toxicodendron dermatitis 10.1 IL2 SELL
23 periodontosis 10.1 SELL TLR4
24 rocky mountain spotted fever 10.1
25 primary bacterial infectious disease 10.1 IL2 TLR4
26 endemic typhus 10.1
27 encephalopathy 10.1
28 pleurisy 10.0 IL2 SELL
29 b-cell expansion with nfkb and t-cell anergy 10.0 IL2 SELL
30 toxic shock syndrome 10.0 IL2 TLR4
31 legg-calve-perthes disease 10.0 SELE THBD
32 enterocolitis 10.0 THBD TLR4
33 diabetic angiopathy 10.0 SELE THBD
34 temporal arteritis 9.9
35 hepatitis 9.9
36 transmitted_by 9.9
37 endotheliitis 9.9
38 thrombotic thrombocytopenic purpura 9.9 SELE THBD
39 carotid artery disease 9.9 SELE THBD
40 lung sarcoma 9.9 IL2 THBD
41 antiphospholipid syndrome 9.8 SELE THBD
42 respiratory system disease 9.8 SERPINA1 TLR4
43 takayasu arteritis 9.8 SELE THBD
44 lymphopenia 9.8 IL2 SELL
45 chronic active epstein-barr virus infection 9.7 IL2 SELE THBD
46 shwartzman phenomenon 9.6 SELE SELL THBD
47 inflammatory bowel disease 9.5 IL2 SELE SELL TLR4
48 peripheral vascular disease 9.5 SELE THBD
49 pre-eclampsia 9.5 SELE SELL THBD
50 malaria 9.4 IL2 SELE THBD TLR4

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to Boutonneuse Fever

Symptoms & Phenotypes for Boutonneuse Fever

Symptoms:

12
  • fever
  • eschar (usually single)
  • regional adenopathy
  • maculopapular rash on extremities

MGI Mouse Phenotypes related to Boutonneuse Fever:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 CP IL2 SELE SELL THBD TLR4
2 cellular MP:0005384 9.8 CP IL2 SELE SELL THBD TLR4
3 hematopoietic system MP:0005397 9.73 CP IL2 SELE SELL THBD TLR4
4 immune system MP:0005387 9.63 IL2 SELE SELL THBD TLR4 CP
5 liver/biliary system MP:0005370 9.43 CP IL2 SELE SELL THBD TLR4
6 respiratory system MP:0005388 9.02 IL2 SELE SELL THBD TLR4

Drugs & Therapeutics for Boutonneuse Fever

Search Clinical Trials , NIH Clinical Center for Boutonneuse Fever

Cochrane evidence based reviews: boutonneuse fever

Genetic Tests for Boutonneuse Fever

Anatomical Context for Boutonneuse Fever

MalaCards organs/tissues related to Boutonneuse Fever:

38
Skin, Endothelial, T Cells, Liver

Publications for Boutonneuse Fever

Articles related to Boutonneuse Fever:

(show all 42)
# Title Authors Year
1
Boutonneuse fever and climate variability. ( 17114701 )
2006
2
Role of TLR4 receptor polymorphisms in Boutonneuse fever. ( 16388712 )
2005
3
Boutonneuse fever in a child: a case report and overview. ( 15473280 )
2004
4
Evaluation of clinical diagnosis scores for Boutonneuse fever. ( 12860646 )
2003
5
Boutonneuse fever in Portugal: 1995-2000. Data of a state laboratory. ( 12800955 )
2003
6
The acute phase response in Sicilian patients with boutonneuse fever admitted to hospitals in Palermo, 1992-1997. ( 11243751 )
2001
7
Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii. ( 10886788 )
2000
8
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever. ( 10444262 )
1999
9
Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. ( 9528898 )
1998
10
Clinical and laboratory findings of boutonneuse fever in Sicilian children. ( 9667405 )
1998
11
Malignant boutonneuse fever and polymyalgia rheumatica: a coincidental association? ( 9334871 )
1997
12
Alteration of interleukin-2 (IL-2) and soluble IL-2 receptor secretion in the sera and urine of patients with rickettsial boutonneuse fever. ( 8985208 )
1997
13
Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. ( 8896508 )
1996
14
[Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. ( 8059165 )
1994
15
High levels of interferon-gamma in boutonneuse fever. ( 7996014 )
1994
16
[Changes in plasma lipoproteins in Mediterranean boutonneuse fever]. ( 1347656 )
1992
17
Spotless boutonneuse fever. ( 1571413 )
1992
18
Spotless boutonneuse fever. ( 1520773 )
1992
19
Epidemiology of boutonneuse fever in western Sicily: accidental laboratory infection with a rickettsial agent isolated from a tick. ( 2273984 )
1990
20
A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. ( 2106490 )
1990
21
Ofloxacin in the treatment of boutonneuse fever. A preliminary report. ( 16312704 )
1989
22
ARDS associated with boutonneuse fever. ( 2924629 )
1989
23
Epidemiology of boutonneuse fever in western Sicily: demonstration of multiple spotted fever group-Rickettsiae subtypes. ( 2779456 )
1989
24
Laboratory diagnosis of boutonneuse fever by enzyme-linked immunosorbent assay. ( 2694514 )
1989
25
Pathogenesis of rickettsial eschars: the tache noire of boutonneuse fever. ( 3192207 )
1988
26
Boutonneuse fever transmitted by conjunctival inoculation. ( 3236764 )
1988
27
Familial cases of boutonneuse fever. ( 3691750 )
1987
28
Boutonneuse fever and Rocky Mountain spotted fever are not alike. ( 3588121 )
1987
29
Epidemiology of boutonneuse fever in western Sicily: isolation of spotted fever group Rickettsiae from Rhipicephalus sanguineus (fam. Ixodidae). ( 3951368 )
1986
30
C-reactive protein in boutonneuse fever. ( 3780711 )
1986
31
Depletion of Hageman factor in acute phase of boutonneuse fever. ( 3580149 )
1986
32
Boutonneuse fever in American travelers. ( 3941277 )
1986
33
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). ( 3513550 )
1986
34
Frequent occurrence of hepatic lesions in boutonneuse fever. ( 2874714 )
1986
35
Persistence of antibodies to Rickettsia conorii after an acute attack of boutonneuse fever. ( 3968457 )
1985
36
Subclinical infections with Boutonneuse fever in western Sicily. ( 4031562 )
1985
37
Vascular permeability in boutonneuse fever. ( 6736678 )
1984
38
A sero-epidemiological survey of asymptomatic cases of Boutonneuse fever in western Sicily. ( 6369650 )
1984
39
The histology of "taches noires" of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. ( 6412440 )
1983
40
Boutonneuse fever. ( 7065712 )
1982
41
Importation into the United States from Africa of Rhipicephalus simus on a boutonneuse fever patient. ( 7258502 )
1981
42
The liver in boutonneuse fever. ( 4479621 )
1974

Variations for Boutonneuse Fever

Expression for Boutonneuse Fever

Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for Boutonneuse Fever

GO Terms for Boutonneuse Fever

Cellular components related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CP IL2 SELE SERPINA1 THBD

Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of inflammatory response GO:0050727 9.43 SELE TLR4
2 positive regulation of inflammatory response GO:0050729 9.4 IL2 TLR4
3 hemostasis GO:0007599 9.37 SERPINA1 THBD
4 leukocyte migration GO:0050900 9.33 SELE SELL THBD
5 positive regulation of interferon-gamma production GO:0032729 9.32 IL2 TLR4
6 positive regulation of B cell proliferation GO:0030890 9.26 IL2 TLR4
7 response to lipopolysaccharide GO:0032496 9.13 SELE THBD TLR4
8 leukocyte tethering or rolling GO:0050901 8.62 SELE SELL

Molecular functions related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.43 SELE THBD TLR4
2 carbohydrate binding GO:0030246 9.33 IL2 SELE SELL
3 oligosaccharide binding GO:0070492 8.96 SELE SELL
4 glycosphingolipid binding GO:0043208 8.62 IL2 SELL

Sources for Boutonneuse Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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