MCID: BTN002
MIFTS: 39

Boutonneuse Fever malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Boutonneuse Fever

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Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Boutonneuse Fever:

Name: Boutonneuse Fever 11 54 39 13 68
Mediterranean Spotted Fever 11 54 50
African Tick Typhus 11 54
Rickettsia Conorii Spotted Fever 11
South African Tick-Bite Fever 11
Conor and Bruch's Disease 11
Mediterranean Tick Fever 11
 
African Tick Bite Fever 68
Boutonneuse Disease 11
Kenyan Tick Typhus 11
Kenya Tick Typhus 11
Marseilles Fever 11
Kenya Fever 11

Characteristics:

Orphanet epidemiological data:

54
boutonneuse fever:
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age
african tick typhus:
Inheritance: Not applicable

Classifications:



External Ids:

Disease Ontology11 DOID:14095
ICD1030 A77.1
ICD9CM32 082.1
MeSH39 D001907
MESH via Orphanet40 D001907
UMLS via Orphanet69 C0006060
ICD10 via Orphanet31 A77.1

Summaries for Boutonneuse Fever

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Disease Ontology:11 A spotted fever that has material basis in Rickettsia conorii subsp conorii, which is transmitted by dog tick (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary: Boutonneuse Fever, also known as mediterranean spotted fever, is related to african tick-bite fever and rosacea, and has symptoms including fever, eschar (usually single) and regional adenopathy. An important gene associated with Boutonneuse Fever is SELE (Selectin E), and among its related pathways are Malaria and Cell adhesion_Cell-matrix glycoconjugates. Affiliated tissues include skin, endothelial and t cells, and related mouse phenotypes are cardiovascular system and cellular.

Wikipedia:71 Boutonneuse fever (also called Mediterranean spotted fever, fièvre boutonneuse, Kenya tick typhus,... more...

Related Diseases for Boutonneuse Fever

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Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1african tick-bite fever11.8
2rosacea10.2CP, SELE
3periosteal chondrosarcoma10.2SELE, SERPINA1
4spotted fever10.2
5hypotrichosis-lymphedema-telangiectasia-renal defect syndrome10.2SELE, SELL
6tick paralysis10.2SELE, SELL
7achilles bursitis10.2CP, SERPINA1
8isolated growth hormone deficiency10.2CP, TLR4
9phlegmonous dacryocystitis10.2SELE, SELL
10ivic syndrome10.2CP, SERPINA1
11growth retardation hydrocephaly lung hypoplasia10.1CP, SERPINA1
12omsk hemorrhagic fever10.1SELL, TLR4
13bornholm eye disease10.1AFF2, SERPINA1
14paralytic poliomyelitis10.1IL2, TLR4
15grix blankenship peterson syndrome10.1CP, SELL
16choroiditis10.1CP, TLR4
17posterior uveitis10.1IL2, SERPINA1
18brain ischemia10.1IL2, TLR4
19chromophobe adenoma10.1IL2, SELL
20abnormal retinal correspondence10.1IL2, TLR4
21myiasis10.0IL2, TLR4
22czech dysplasia10.0SELE, THBD
23neonatal diabetes mellitus10.0SELE, THBD
24encephalopathy10.0
25thyroid cancer, anaplastic10.0SELE, THBD
26mansonelliasis10.0IL2, TLR4
27strawberry gallbladder10.0IL2, SELL
28rocky mountain spotted fever10.0
29hyperaldosteronism, familial, type ii10.0IL2, SELL
30liver inflammatory pseudotumor10.0IL2, TLR4
31byssinosis10.0SERPINA1, THBD
32dengue hemorrhagic fever9.9IL2, TLR4
33optic nerve neoplasm9.9SELE, THBD
34craniopharyngioma9.9SELE, SELL, THBD
35hepatitis9.8
36transmitted_by9.8
37endotheliitis9.8
38chronic thromboembolic pulmonary hypertension9.8IL2, SELE, THBD
39pemphigus vulgaris, familial9.8IL2, SELE, THBD
40sertoli-leydig cell tumor9.8SELE, THBD
41eating disorder9.7SELE, SELL, SERPINA1, THBD
42immunodeficiency due to defect in mapbp-interacting protein9.7IL2, SELE, THBD, TLR4
43visceral leishmaniasis9.6
44goodpasture syndrome9.3CP, IL2, SELE, SELL, THBD, TLR4
45de quervain disease8.9AFF2, CP, IL2, SELE, SELL, SERPINA1

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to boutonneuse fever

Symptoms & Phenotypes for Boutonneuse Fever

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Symptoms:

 11 (show all 4)
  • fever
  • eschar (usually single)
  • regional adenopathy
  • maculopapular rash on extremities

MGI Mouse Phenotypes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2CP, IL2, SELE, SELL, THBD, TLR4
2MP:00053848.2CP, IL2, SELE, SELL, THBD, TLR4
3MP:00053978.2CP, IL2, SELE, SELL, THBD, TLR4
4MP:00053878.1CP, IL2, SELE, SELL, THBD, TLR4
5MP:00053708.1CP, IL2, SELE, SELL, THBD, TLR4
6MP:00053887.8IL2, SELE, SELL, THBD, TLR4

Drugs & Therapeutics for Boutonneuse Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Boutonneuse Fever


Cochrane evidence based reviews: boutonneuse fever

Genetic Tests for Boutonneuse Fever

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Anatomical Context for Boutonneuse Fever

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MalaCards organs/tissues related to Boutonneuse Fever:

36
Skin, Endothelial, T cells, Liver

Publications for Boutonneuse Fever

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Articles related to Boutonneuse Fever:

(show all 42)
idTitleAuthorsYear
1
Boutonneuse fever and climate variability. (17114701)
2006
2
Role of TLR4 receptor polymorphisms in Boutonneuse fever. (16388712)
2005
3
Boutonneuse fever in a child: a case report and overview. (15473280)
2004
4
Boutonneuse fever in Portugal: 1995-2000. Data of a state laboratory. (12800955)
2003
5
Evaluation of clinical diagnosis scores for Boutonneuse fever. (12860646)
2003
6
The acute phase response in Sicilian patients with boutonneuse fever admitted to hospitals in Palermo, 1992-1997. (11243751)
2001
7
Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii. (10886788)
2000
8
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever. (10444262)
1999
9
Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. (9528898)
1998
10
Clinical and laboratory findings of boutonneuse fever in Sicilian children. (9667405)
1998
11
Malignant boutonneuse fever and polymyalgia rheumatica: a coincidental association? (9334871)
1997
12
Alteration of interleukin-2 (IL-2) and soluble IL-2 receptor secretion in the sera and urine of patients with rickettsial boutonneuse fever. (8985208)
1997
13
Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. (8896508)
1996
14
Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. (8059165)
1994
15
High levels of interferon-gamma in boutonneuse fever. (7996014)
1994
16
Spotless boutonneuse fever. (1571413)
1992
17
Changes in plasma lipoproteins in Mediterranean boutonneuse fever]. (1347656)
1992
18
Spotless boutonneuse fever. (1520773)
1992
19
A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. (2106490)
1990
20
Epidemiology of boutonneuse fever in western Sicily: accidental laboratory infection with a rickettsial agent isolated from a tick. (2273984)
1990
21
Epidemiology of boutonneuse fever in western Sicily: demonstration of multiple spotted fever group-Rickettsiae subtypes. (2779456)
1989
22
ARDS associated with boutonneuse fever. (2924629)
1989
23
Laboratory diagnosis of boutonneuse fever by enzyme-linked immunosorbent assay. (2694514)
1989
24
Ofloxacin in the treatment of boutonneuse fever. A preliminary report. (16312704)
1989
25
Boutonneuse fever transmitted by conjunctival inoculation. (3236764)
1988
26
Pathogenesis of rickettsial eschars: the tache noire of boutonneuse fever. (3192207)
1988
27
Boutonneuse fever and Rocky Mountain spotted fever are not alike. (3588121)
1987
28
Familial cases of boutonneuse fever. (3691750)
1987
29
Boutonneuse fever in American travelers. (3941277)
1986
30
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). (3513550)
1986
31
Epidemiology of boutonneuse fever in western Sicily: isolation of spotted fever group Rickettsiae from Rhipicephalus sanguineus (fam. Ixodidae). (3951368)
1986
32
Frequent occurrence of hepatic lesions in boutonneuse fever. (2874714)
1986
33
Depletion of Hageman factor in acute phase of boutonneuse fever. (3580149)
1986
34
C-reactive protein in boutonneuse fever. (3780711)
1986
35
Persistence of antibodies to Rickettsia conorii after an acute attack of boutonneuse fever. (3968457)
1985
36
Subclinical infections with Boutonneuse fever in western Sicily. (4031562)
1985
37
A sero-epidemiological survey of asymptomatic cases of Boutonneuse fever in western Sicily. (6369650)
1984
38
Vascular permeability in boutonneuse fever. (6736678)
1984
39
The histology of "taches noires" of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. (6412440)
1983
40
Boutonneuse fever. (7065712)
1982
41
Importation into the United States from Africa of Rhipicephalus simus on a boutonneuse fever patient. (7258502)
1981
42
The liver in boutonneuse fever. (4479621)
1974

Variations for Boutonneuse Fever

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Expression for genes affiliated with Boutonneuse Fever

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Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for genes affiliated with Boutonneuse Fever

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GO Terms for genes affiliated with Boutonneuse Fever

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Cellular components related to Boutonneuse Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.8CP, IL2, SELE, SERPINA1, THBD

Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of inflammatory responseGO:005072710.3SELE, TLR4
2positive regulation of B cell proliferationGO:003089010.1IL2, TLR4
3positive regulation of inflammatory responseGO:005072910.1IL2, TLR4
4positive regulation of interferon-gamma productionGO:003272910.1IL2, TLR4
5hemostasisGO:00075999.9SERPINA1, THBD
6leukocyte migrationGO:00509009.4SELE, SELL, THBD
7response to lipopolysaccharideGO:00324968.9SELE, THBD, TLR4

Molecular functions related to Boutonneuse Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycosphingolipid bindingGO:00432089.9IL2, SELL
2carbohydrate bindingGO:00302469.6IL2, SELE, SELL
3transmembrane signaling receptor activityGO:00048888.9SELE, THBD, TLR4

Sources for Boutonneuse Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet