MCID: BTN002
MIFTS: 37

Boutonneuse Fever malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Boutonneuse Fever

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Sources:
11Disease Ontology, 13DISEASES, 52Orphanet, 37MeSH, 66UMLS, 48Novoseek, 28ICD10, 30ICD9CM, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Boutonneuse Fever:

Name: Boutonneuse Fever 11 13 52 37 66
Mediterranean Spotted Fever 11 48
African Tick Typhus 11 52
Rickettsia Conorii Spotted Fever 11
South African Tick-Bite Fever 11
Conor and Bruch's Disease 11
Mediterranean Tick Fever 11
 
African Tick Bite Fever 66
Boutonneuse Disease 11
Kenyan Tick Typhus 11
Kenya Tick Typhus 11
Marseilles Fever 11
Kenya Fever 11

Characteristics:

Orphanet epidemiological data:

52
boutonneuse fever:
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age
african tick typhus:
Inheritance: Not applicable

Classifications:



External Ids:

Disease Ontology11 DOID:14095
ICD1028 A77.1
ICD9CM30 082.1
MeSH37 D001907
ICD10 via Orphanet29 A77.1
MESH via Orphanet38 D001907
UMLS via Orphanet67 C0006060

Summaries for Boutonneuse Fever

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Disease Ontology:11 A spotted fever that has material basis in rickettsia conorii subsp conorii, which is transmitted by dog tick (rhipicephalus sanguineus). the infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary: Boutonneuse Fever, also known as mediterranean spotted fever, is related to african tick-bite fever and rectal disease, and has symptoms including fever, eschar (usually single) and regional adenopathy. An important gene associated with Boutonneuse Fever is TLR4 (Toll Like Receptor 4), and among its related pathways are Malaria and Glucocorticoid receptor regulatory network. Affiliated tissues include skin, endothelial and t cells, and related mouse phenotype liver/biliary system.

Wikipedia:69 Boutonneuse fever (also called Mediterranean spotted fever, fièvre boutonneuse, Kenya tick typhus,... more...

Related Diseases for Boutonneuse Fever

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Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1african tick-bite fever11.9
2rectal disease10.4CP, SERPINA1
3paranasal sinus cancer, adult10.4CP, SERPINA1
4ivic syndrome10.4CP, SERPINA1
5lupus erythematosus10.4CP, SELE
6bulbospinal polio10.3IL2, TLR4
7diphtheria10.3CP, TLR4
8posterolateral myocardial infarction10.3SELE, SERPINA1
9spotted fever10.3
10neonatal thyrotoxicosis10.3IL2, SERPINA1
11brain injury10.3IL2, TLR4
12esophagus melanoma10.2IL2, TLR4
13dengue disease10.2IL2, TLR4
14gastric ulcer10.2IL2, TLR4
15granulomatous hypophysitis10.2CP, SELL
16meibomian cyst10.2SELL, TLR4
17laryngeal tuberculosis10.2SERPINA1, TLR4
18calcifying epithelial odontogenic tumor10.2IL2, SELE
19variola minor10.2IL2, TLR4
20typhus10.1
21encephalopathy10.1
22rocky mountain spotted fever10.1
23eczematous dermatitis of eyelid10.1IL2, SERPINA1
24shwartzman phenomenon10.1IL2, SELL
25chromophobe adenoma10.1SELE, SELL
26central gyrate choroidal dystrophy10.1SELE, SELL
27emphysema, congenital lobar10.0IL2, SELE
28bornholm eye disease10.0AFF2, SERPINA1
29perianal skin paget's disease10.0SERPINA1, TLR4
30louping ill10.0IL2, SELL
31hepatitis10.0
32transmitted_by10.0
33endotheliitis10.0
34gemistocytic astrocytoma9.9IL2, SELE, TLR4
35hodgkin's lymphoma, mixed cellularity9.9IL2, SELE
36microcephalic osteodysplastic primordial dwarfism, type ii9.8SELE, SELL
37hyperuricemia, pulmonary hypertension, renal failure, and alkalosis9.8SELE, SELL
38low compliance bladder9.7IL2, TLR4
39goodpasture syndrome9.0CP, IL2, SELE, SELL, TLR4
40acquired gastric outlet stenosis7.3AFF2, CP, IL2, IRS4, SELE, SELL

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to boutonneuse fever

Symptoms for Boutonneuse Fever

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Symptoms:

 11
  • fever
  • eschar (usually single)
  • regional adenopathy
  • maculopapular rash on extremities

Drugs & Therapeutics for Boutonneuse Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Boutonneuse Fever


Cochrane evidence based reviews: boutonneuse fever

Genetic Tests for Boutonneuse Fever

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Anatomical Context for Boutonneuse Fever

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MalaCards organs/tissues related to Boutonneuse Fever:

34
Skin, Endothelial, T cells, Liver

Animal Models for Boutonneuse Fever or affiliated genes

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MGI Mouse Phenotypes related to Boutonneuse Fever:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.2CP, IL2, SELE, SELL, TLR4

Publications for Boutonneuse Fever

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Articles related to Boutonneuse Fever:

(show all 42)
idTitleAuthorsYear
1
Boutonneuse fever and climate variability. (17114701)
2006
2
Role of TLR4 receptor polymorphisms in Boutonneuse fever. (16388712)
2005
3
Boutonneuse fever in a child: a case report and overview. (15473280)
2004
4
Boutonneuse fever in Portugal: 1995-2000. Data of a state laboratory. (12800955)
2003
5
Evaluation of clinical diagnosis scores for Boutonneuse fever. (12860646)
2003
6
The acute phase response in Sicilian patients with boutonneuse fever admitted to hospitals in Palermo, 1992-1997. (11243751)
2001
7
Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii. (10886788)
2000
8
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever. (10444262)
1999
9
Clinical and laboratory findings of boutonneuse fever in Sicilian children. (9667405)
1998
10
Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. (9528898)
1998
11
Alteration of interleukin-2 (IL-2) and soluble IL-2 receptor secretion in the sera and urine of patients with rickettsial boutonneuse fever. (8985208)
1997
12
Malignant boutonneuse fever and polymyalgia rheumatica: a coincidental association? (9334871)
1997
13
Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. (8896508)
1996
14
High levels of interferon-gamma in boutonneuse fever. (7996014)
1994
15
Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. (8059165)
1994
16
Changes in plasma lipoproteins in Mediterranean boutonneuse fever]. (1347656)
1992
17
Spotless boutonneuse fever. (1520773)
1992
18
Spotless boutonneuse fever. (1571413)
1992
19
Epidemiology of boutonneuse fever in western Sicily: accidental laboratory infection with a rickettsial agent isolated from a tick. (2273984)
1990
20
A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. (2106490)
1990
21
Epidemiology of boutonneuse fever in western Sicily: demonstration of multiple spotted fever group-Rickettsiae subtypes. (2779456)
1989
22
ARDS associated with boutonneuse fever. (2924629)
1989
23
Ofloxacin in the treatment of boutonneuse fever. A preliminary report. (16312704)
1989
24
Laboratory diagnosis of boutonneuse fever by enzyme-linked immunosorbent assay. (2694514)
1989
25
Boutonneuse fever transmitted by conjunctival inoculation. (3236764)
1988
26
Pathogenesis of rickettsial eschars: the tache noire of boutonneuse fever. (3192207)
1988
27
Boutonneuse fever and Rocky Mountain spotted fever are not alike. (3588121)
1987
28
Familial cases of boutonneuse fever. (3691750)
1987
29
Frequent occurrence of hepatic lesions in boutonneuse fever. (2874714)
1986
30
C-reactive protein in boutonneuse fever. (3780711)
1986
31
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). (3513550)
1986
32
Epidemiology of boutonneuse fever in western Sicily: isolation of spotted fever group Rickettsiae from Rhipicephalus sanguineus (fam. Ixodidae). (3951368)
1986
33
Boutonneuse fever in American travelers. (3941277)
1986
34
Depletion of Hageman factor in acute phase of boutonneuse fever. (3580149)
1986
35
Subclinical infections with Boutonneuse fever in western Sicily. (4031562)
1985
36
Persistence of antibodies to Rickettsia conorii after an acute attack of boutonneuse fever. (3968457)
1985
37
Vascular permeability in boutonneuse fever. (6736678)
1984
38
A sero-epidemiological survey of asymptomatic cases of Boutonneuse fever in western Sicily. (6369650)
1984
39
The histology of "taches noires" of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. (6412440)
1983
40
Boutonneuse fever. (7065712)
1982
41
Importation into the United States from Africa of Rhipicephalus simus on a boutonneuse fever patient. (7258502)
1981
42
The liver in boutonneuse fever. (4479621)
1974

Variations for Boutonneuse Fever

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Expression for genes affiliated with Boutonneuse Fever

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Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for genes affiliated with Boutonneuse Fever

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GO Terms for genes affiliated with Boutonneuse Fever

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Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-gamma productionGO:00327299.9IL2, TLR4
2positive regulation of B cell proliferationGO:00308909.7IL2, TLR4
3regulation of inflammatory responseGO:00507279.7SELE, TLR4
4positive regulation of inflammatory responseGO:00507299.3IL2, TLR4

Molecular functions related to Boutonneuse Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycosphingolipid bindingGO:00432089.3IL2, SELL

Sources for Boutonneuse Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet