MCID: BTN002
MIFTS: 39

Boutonneuse Fever malady

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Boutonneuse Fever

Aliases & Descriptions for Boutonneuse Fever:

Name: Boutonneuse Fever 12 56 42 14 69
Mediterranean Spotted Fever 12 56 52
African Tick Typhus 12 56
Rickettsia Conorii Spotted Fever 12
South African Tick-Bite Fever 12
Conor and Bruch's Disease 12
Mediterranean Tick Fever 12
African Tick Bite Fever 69
Boutonneuse Disease 12
Kenyan Tick Typhus 12
Kenya Tick Typhus 12
Marseilles Fever 12
Kenya Fever 12

Characteristics:

Orphanet epidemiological data:

56
boutonneuse fever
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
african tick typhus
Inheritance: Not applicable;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14095
ICD10 33 A77.1
ICD9CM 35 082.1
MeSH 42 D001907
MESH via Orphanet 43 D001907
UMLS via Orphanet 70 C0006060
ICD10 via Orphanet 34 A77.1
UMLS 69 C0006060

Summaries for Boutonneuse Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia conorii subsp conorii, which is transmitted_by dog tick (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary : Boutonneuse Fever, also known as mediterranean spotted fever, is related to african tick-bite fever and rosacea, and has symptoms including fever, eschar (usually single) and regional adenopathy. An important gene associated with Boutonneuse Fever is SELE (Selectin E), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Affiliated tissues include skin, t cells and endothelial, and related phenotypes are cardiovascular system and cellular

Wikipedia : 71 Boutonneuse fever (also called Mediterranean spotted fever, fièvre boutonneuse, Kenya tick typhus,... more...

Related Diseases for Boutonneuse Fever

Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
id Related Disease Score Top Affiliating Genes
1 african tick-bite fever 11.8
2 rosacea 10.2 CP SELE
3 periosteal chondrosarcoma 10.2 SELE SERPINA1
4 spotted fever 10.2
5 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.2 SELE SELL
6 tick paralysis 10.2 SELE SELL
7 achilles bursitis 10.2 CP SERPINA1
8 isolated growth hormone deficiency 10.2 CP TLR4
9 phlegmonous dacryocystitis 10.2 SELE SELL
10 ivic syndrome 10.2 CP SERPINA1
11 growth retardation hydrocephaly lung hypoplasia 10.1 CP SERPINA1
12 omsk hemorrhagic fever 10.1 SELL TLR4
13 bornholm eye disease 10.1 AFF2 SERPINA1
14 paralytic poliomyelitis 10.1 IL2 TLR4
15 grix blankenship peterson syndrome 10.1 CP SELL
16 choroiditis 10.1 CP TLR4
17 posterior uveitis 10.1 IL2 SERPINA1
18 brain ischemia 10.1 IL2 TLR4
19 chromophobe adenoma 10.1 IL2 SELL
20 abnormal retinal correspondence 10.1 IL2 TLR4
21 myiasis 10.0 IL2 TLR4
22 czech dysplasia 10.0 SELE THBD
23 neonatal diabetes mellitus 10.0 SELE THBD
24 encephalopathy 10.0
25 thyroid cancer, anaplastic 10.0 SELE THBD
26 mansonelliasis 10.0 IL2 TLR4
27 strawberry gallbladder 10.0 IL2 SELL
28 rocky mountain spotted fever 10.0
29 hyperaldosteronism, familial, type ii 10.0 IL2 SELL
30 liver inflammatory pseudotumor 10.0 IL2 TLR4
31 byssinosis 10.0 SERPINA1 THBD
32 dengue hemorrhagic fever 9.9 IL2 TLR4
33 optic nerve neoplasm 9.9 SELE THBD
34 craniopharyngioma 9.9 SELE SELL THBD
35 transmitted_by 9.8
36 endotheliitis 9.8
37 hepatitis 9.8
38 chronic thromboembolic pulmonary hypertension 9.8 IL2 SELE THBD
39 pemphigus vulgaris, familial 9.8 IL2 SELE THBD
40 sertoli-leydig cell tumor 9.8 SELE THBD
41 eating disorder 9.7 SELE SELL SERPINA1 THBD
42 immunodeficiency due to defect in mapbp-interacting protein 9.7 IL2 SELE THBD TLR4
43 visceral leishmaniasis 9.6
44 goodpasture syndrome 9.3 CP IL2 SELE SELL THBD TLR4
45 de quervain disease 8.9 AFF2 CP IL2 SELE SELL SERPINA1

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to Boutonneuse Fever

Symptoms & Phenotypes for Boutonneuse Fever

Symptoms:

12
  • fever
  • eschar (usually single)
  • regional adenopathy
  • maculopapular rash on extremities

MGI Mouse Phenotypes related to Boutonneuse Fever:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 CP IL2 SELE SELL THBD TLR4
2 cellular MP:0005384 9.8 IL2 SELE SELL THBD TLR4 CP
3 hematopoietic system MP:0005397 9.73 CP IL2 SELE SELL THBD TLR4
4 immune system MP:0005387 9.63 CP IL2 SELE SELL THBD TLR4
5 liver/biliary system MP:0005370 9.43 SELE SELL THBD TLR4 CP IL2
6 respiratory system MP:0005388 9.02 IL2 SELE SELL THBD TLR4

Drugs & Therapeutics for Boutonneuse Fever

Search Clinical Trials , NIH Clinical Center for Boutonneuse Fever

Cochrane evidence based reviews: boutonneuse fever

Genetic Tests for Boutonneuse Fever

Anatomical Context for Boutonneuse Fever

MalaCards organs/tissues related to Boutonneuse Fever:

39
Skin, T Cells, Endothelial, Liver

Publications for Boutonneuse Fever

Articles related to Boutonneuse Fever:

(show all 42)
id Title Authors Year
1
Boutonneuse fever and climate variability. ( 17114701 )
2006
2
Role of TLR4 receptor polymorphisms in Boutonneuse fever. ( 16388712 )
2005
3
Boutonneuse fever in a child: a case report and overview. ( 15473280 )
2004
4
Boutonneuse fever in Portugal: 1995-2000. Data of a state laboratory. ( 12800955 )
2003
5
Evaluation of clinical diagnosis scores for Boutonneuse fever. ( 12860646 )
2003
6
The acute phase response in Sicilian patients with boutonneuse fever admitted to hospitals in Palermo, 1992-1997. ( 11243751 )
2001
7
Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii. ( 10886788 )
2000
8
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever. ( 10444262 )
1999
9
Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. ( 9528898 )
1998
10
Clinical and laboratory findings of boutonneuse fever in Sicilian children. ( 9667405 )
1998
11
Malignant boutonneuse fever and polymyalgia rheumatica: a coincidental association? ( 9334871 )
1997
12
Alteration of interleukin-2 (IL-2) and soluble IL-2 receptor secretion in the sera and urine of patients with rickettsial boutonneuse fever. ( 8985208 )
1997
13
Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. ( 8896508 )
1996
14
[Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. ( 8059165 )
1994
15
High levels of interferon-gamma in boutonneuse fever. ( 7996014 )
1994
16
Spotless boutonneuse fever. ( 1571413 )
1992
17
[Changes in plasma lipoproteins in Mediterranean boutonneuse fever]. ( 1347656 )
1992
18
Spotless boutonneuse fever. ( 1520773 )
1992
19
A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. ( 2106490 )
1990
20
Epidemiology of boutonneuse fever in western Sicily: accidental laboratory infection with a rickettsial agent isolated from a tick. ( 2273984 )
1990
21
Epidemiology of boutonneuse fever in western Sicily: demonstration of multiple spotted fever group-Rickettsiae subtypes. ( 2779456 )
1989
22
ARDS associated with boutonneuse fever. ( 2924629 )
1989
23
Laboratory diagnosis of boutonneuse fever by enzyme-linked immunosorbent assay. ( 2694514 )
1989
24
Ofloxacin in the treatment of boutonneuse fever. A preliminary report. ( 16312704 )
1989
25
Boutonneuse fever transmitted by conjunctival inoculation. ( 3236764 )
1988
26
Pathogenesis of rickettsial eschars: the tache noire of boutonneuse fever. ( 3192207 )
1988
27
Boutonneuse fever and Rocky Mountain spotted fever are not alike. ( 3588121 )
1987
28
Familial cases of boutonneuse fever. ( 3691750 )
1987
29
Boutonneuse fever in American travelers. ( 3941277 )
1986
30
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). ( 3513550 )
1986
31
Epidemiology of boutonneuse fever in western Sicily: isolation of spotted fever group Rickettsiae from Rhipicephalus sanguineus (fam. Ixodidae). ( 3951368 )
1986
32
Frequent occurrence of hepatic lesions in boutonneuse fever. ( 2874714 )
1986
33
Depletion of Hageman factor in acute phase of boutonneuse fever. ( 3580149 )
1986
34
C-reactive protein in boutonneuse fever. ( 3780711 )
1986
35
Persistence of antibodies to Rickettsia conorii after an acute attack of boutonneuse fever. ( 3968457 )
1985
36
Subclinical infections with Boutonneuse fever in western Sicily. ( 4031562 )
1985
37
A sero-epidemiological survey of asymptomatic cases of Boutonneuse fever in western Sicily. ( 6369650 )
1984
38
Vascular permeability in boutonneuse fever. ( 6736678 )
1984
39
The histology of "taches noires" of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. ( 6412440 )
1983
40
Boutonneuse fever. ( 7065712 )
1982
41
Importation into the United States from Africa of Rhipicephalus simus on a boutonneuse fever patient. ( 7258502 )
1981
42
The liver in boutonneuse fever. ( 4479621 )
1974

Variations for Boutonneuse Fever

Expression for Boutonneuse Fever

Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for Boutonneuse Fever

GO Terms for Boutonneuse Fever

Cellular components related to Boutonneuse Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CP IL2 SELE SERPINA1 THBD

Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of inflammatory response GO:0050727 9.4 SELE TLR4
2 positive regulation of inflammatory response GO:0050729 9.37 IL2 TLR4
3 hemostasis GO:0007599 9.32 SERPINA1 THBD
4 positive regulation of interferon-gamma production GO:0032729 9.26 IL2 TLR4
5 positive regulation of B cell proliferation GO:0030890 9.16 IL2 TLR4
6 leukocyte migration GO:0050900 9.13 SELE SELL THBD
7 response to lipopolysaccharide GO:0032496 8.8 SELE THBD TLR4

Molecular functions related to Boutonneuse Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.33 SELE THBD TLR4
2 carbohydrate binding GO:0030246 9.13 IL2 SELE SELL
3 glycosphingolipid binding GO:0043208 8.62 IL2 SELL

Sources for Boutonneuse Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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