MCID: BTN002
MIFTS: 47

Boutonneuse Fever malady

Infectious diseases, Rare diseases categories
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Summaries for Boutonneuse Fever

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A spotted fever that has material basis in rickettsia conorii subsp conorii, which is transmitted by dog tick (rhipicephalus sanguineus). the infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards: Boutonneuse Fever, also known as african tick typhus, is related to african tick-bite fever and spotted fever, and has symptoms including fever, eschar (usually single) and regional adenopathy. An important gene associated with Boutonneuse Fever is IRS4 (insulin receptor substrate 4), and among its related pathways is Adipogenesis. The compounds thiobarbituric acid and sodium azide have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and endothelial, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Wikipedia:65 Boutonneuse fever (also called Mediterranean spotted fever, fi more...

Aliases & Classifications for Boutonneuse Fever

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8Disease Ontology, 10DISEASES, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

49
boutonneuse fever:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

boutonneuse fever 8 10 49 62
african tick typhus 8 49
kenya tick typhus 8 49
marseilles fever 8 49
rickettsia conorii spotted fever 8
south african tick-bite fever 8
african tick bite fever 62
kenya tick-bite fever 49


External Ids:

Disease Ontology8 DOID:14095
MeSH35 D001907
ICD9CM27 082.1
MESH via Orphanet36 D001907
ICD10 via Orphanet26 A77.1
SNOMED-CT via Orphanet59 186774005
UMLS via Orphanet63 C0006060

Related Diseases for Boutonneuse Fever

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17GeneCards, 18GeneDecks
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Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1african tick-bite fever10.8
2spotted fever10.5
3typhus10.5
4rocky mountain spotted fever10.3
5polymyalgia rheumatica10.2
6hepatitis10.2
7endotheliitis10.2
8mediterranean spotted fever10.2
9siderosis10.1CP
10malaria10.0G6PD, CP
11wilson disease10.0G6PD, CP
12iron metabolism disease10.0G6PD, CP
13hemolytic anemia10.0G6PD, CP
14adult respiratory distress syndrome10.0CP, SERPINA1
15hemochromatosis10.0CP, SERPINA1
16cholestasis10.0CP, SERPINA1
17viral hepatitis10.0G6PD, SERPINA1
18pancreatitis, chronic10.0SERPINA1, LPL
19nephrotic syndrome10.0SERPINA1, LPL
20pancreatitis10.0LPL, SERPINA1
21metabolic syndrome x10.0LPL, G6PD
22liver cirrhosis10.0SERPINA1, CP
23deficiency anemia10.0CP, G6PD, LPL
24ankylosing spondylitis10.0TLR4, SERPINA1
25colorectal cancer10.0LPL, CP, SERPINA1
26galactosemia10.0SERPINA1, TLR4
27dementia10.0LPL, CP
28b-cell chronic lymphocytic leukemia10.0LPL, TLR4
29hepatitis c10.0SERPINA1, TLR4
30congenital heart disease10.0G6PD, CP, TLR4
31cerebrovascular disease10.0TLR4, CP, LPL
32coronary artery disease10.0LPL, TLR4
33tuberculosis10.0CP, SERPINA1, TLR4
34hypersensitivity reaction type ii disease9.9TLR4, G6PD, LPL
35acute pancreatitis9.9TLR4, SERPINA1, LPL
36ulcerative colitis9.9LPL, SERPINA1, TLR4
37asthma9.9TLR4, SERPINA1, CP
38viral infectious disease9.9G6PD, SERPINA1, TLR4
39burkitt's lymphoma9.9TLR4, SERPINA1, CP
40diabetes mellitus9.9SERPINA1, CP, G6PD, LPL
41breast cancer9.9IRS4, G6PD, CP, SERPINA1
42lung cancer9.9TLR4, SERPINA1, LPL
43atherosclerosis9.9TLR4, CP, G6PD, LPL
44cystic fibrosis9.9LPL, CP, SERPINA1, TLR4
45rheumatoid arthritis9.9LPL, CP, SERPINA1, TLR4
46melanoma9.9TLR4, SERPINA1, CP, LPL

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to boutonneuse fever

Symptoms for Boutonneuse Fever

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8Disease Ontology
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Symptoms:

8
  • fever
  • eschar (usually single)
  • regional adenopathy
  • maculopapular rash on extremities

Drugs & Therapeutics for Boutonneuse Fever

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Boutonneuse Fever

Genetic Tests for Boutonneuse Fever

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Anatomical Context for Boutonneuse Fever

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33MalaCards
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MalaCards organs/tissues related to Boutonneuse Fever:

33
Liver, T cells, Endothelial

Animal Models for Boutonneuse Fever or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Boutonneuse Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2LPL, G6PD, CP, TLR4
2MP:00053767.4LPL, IRS4, G6PD, CP, TLR4

Publications for Boutonneuse Fever

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52PubMed
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Articles related to Boutonneuse Fever:

(show all 41)
idTitleAuthorsYear
1
Boutonneuse fever and climate variability. (17114701)
2006
2
Role of TLR4 receptor polymorphisms in Boutonneuse fever. (16388712)
2005
3
Boutonneuse fever in a child: a case report and overview. (15473280)
2004
4
Boutonneuse fever in Portugal: 1995-2000. Data of a state laboratory. (12800955)
2003
5
Evaluation of clinical diagnosis scores for Boutonneuse fever. (12860646)
2003
6
The acute phase response in Sicilian patients with boutonneuse fever admitted to hospitals in Palermo, 1992-1997. (11243751)
2001
7
Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii. (10886788)
2000
8
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever. (10444262)
1999
9
Clinical and laboratory findings of boutonneuse fever in Sicilian children. (9667405)
1998
10
Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. (9528898)
1998
11
Alteration of interleukin-2 (IL-2) and soluble IL-2 receptor secretion in the sera and urine of patients with rickettsial boutonneuse fever. (8985208)
1997
12
Malignant boutonneuse fever and polymyalgia rheumatica: a coincidental association? (9334871)
1997
13
Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. (8896508)
1996
14
Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. (8059165)
1994
15
Changes in plasma lipoproteins in Mediterranean boutonneuse fever]. (1347656)
1992
16
Spotless boutonneuse fever. (1520773)
1992
17
Spotless boutonneuse fever. (1571413)
1992
18
Epidemiology of boutonneuse fever in western Sicily: accidental laboratory infection with a rickettsial agent isolated from a tick. (2273984)
1990
19
A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. (2106490)
1990
20
Ofloxacin in the treatment of boutonneuse fever. A preliminary report. (16312704)
1989
21
Epidemiology of boutonneuse fever in western Sicily: demonstration of multiple spotted fever group-Rickettsiae subtypes. (2779456)
1989
22
ARDS associated with boutonneuse fever. (2924629)
1989
23
Laboratory diagnosis of boutonneuse fever by enzyme-linked immunosorbent assay. (2694514)
1989
24
Pathogenesis of rickettsial eschars: the tache noire of boutonneuse fever. (3192207)
1988
25
Boutonneuse fever transmitted by conjunctival inoculation. (3236764)
1988
26
Boutonneuse fever and Rocky Mountain spotted fever are not alike. (3588121)
1987
27
Familial cases of boutonneuse fever. (3691750)
1987
28
C-reactive protein in boutonneuse fever. (3780711)
1986
29
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). (3513550)
1986
30
Epidemiology of boutonneuse fever in western Sicily: isolation of spotted fever group Rickettsiae from Rhipicephalus sanguineus (fam. Ixodidae). (3951368)
1986
31
Boutonneuse fever in American travelers. (3941277)
1986
32
Frequent occurrence of hepatic lesions in boutonneuse fever. (2874714)
1986
33
Depletion of Hageman factor in acute phase of boutonneuse fever. (3580149)
1986
34
Subclinical infections with Boutonneuse fever in western Sicily. (4031562)
1985
35
Persistence of antibodies to Rickettsia conorii after an acute attack of boutonneuse fever. (3968457)
1985
36
A sero-epidemiological survey of asymptomatic cases of Boutonneuse fever in western Sicily. (6369650)
1984
37
Vascular permeability in boutonneuse fever. (6736678)
1984
38
The histology of "taches noires" of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. (6412440)
1983
39
Boutonneuse fever. (7065712)
1982
40
Importation into the United States from Africa of Rhipicephalus simus on a boutonneuse fever patient. (7258502)
1981
41
The liver in boutonneuse fever. (4479621)
1974

Variations for Boutonneuse Fever

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Expression for genes affiliated with Boutonneuse Fever

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Boutonneuse Fever

Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for genes affiliated with Boutonneuse Fever

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50PathCards, 38NCBI BioSystems Database
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Pathways related to Boutonneuse Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5LPL, IRS4

Compounds for genes affiliated with Boutonneuse Fever

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 3BitterDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Boutonneuse Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1thiobarbituric acid459.9G6PD, CP
2sodium azide459.9CP, G6PD
3dehydroascorbic acid45 1110.9G6PD, CP
4lycopene45 2410.9CP, LPL
5ciprofloxacin45 51 1111.9CP, G6PD
6methimazole45 3 1111.8G6PD, CP
7acetone459.8G6PD, LPL
8protamine459.8LPL, CP
9starch459.8G6PD, LPL
10gemfibrozil29 45 1111.8LPL, G6PD
11hypoxanthine45 24 1111.8CP, G6PD
12glycerol 3-phosphate45 2410.7LPL, G6PD
13glibenclamide45 29 51 6112.7CP, G6PD
14alpha lipoic acid459.7G6PD, SERPINA1
15vitamin b12459.6G6PD, CP
16betacarotene459.6LPL, CP
17pioglitazone29 45 51 1112.4LPL, G6PD
18tocopherol459.4G6PD, LPL, CP
19phenobarbital45 29 51 1112.4LPL, G6PD, CP
20carnitine459.4LPL, CP, G6PD
21alpha tocopherol459.4G6PD, CP, LPL
22thyroxine45 2410.4LPL, CP, G6PD
23diphenyleneiodonium459.4G6PD, TLR4
24epinephrine45 24 1111.4LPL, G6PD, CP
25salicylic acid45 2910.3SERPINA1, G6PD
26guanidine hydrochloride459.3G6PD, LPL
27glutamine459.3CP, LPL, G6PD
28vitamin a45 24 1111.3CP, LPL, SERPINA1
29ascorbic acid45 2410.3CP, G6PD, SERPINA1
30malondialdehyde459.2G6PD, CP
31creatinine459.1SERPINA1, G6PD, CP
32adenylate459.1CP, LPL, G6PD
33carbohydrates459.1CP, LPL, TLR4
34heparin45 29 24 1112.1LPL, CP, SERPINA1
35vitamin d459.1TLR4, LPL, CP
36superoxide45 2410.0TLR4, CP, G6PD
37fibrinogen459.0SERPINA1, TLR4, CP
38aspartate458.9CP, G6PD, TLR4
39polysaccharide458.9TLR4, SERPINA1, LPL
40iron45 249.9SERPINA1, CP, TLR4
41phospholipid458.9LPL, SERPINA1, TLR4
42arachidonic acid45 29 24 1111.9SERPINA1, TLR4, LPL
43nadph45 249.9SERPINA1, TLR4, G6PD
44estrogen458.8LPL, G6PD, CP, SERPINA1
45lactate458.6CP, LPL, G6PD, TLR4
46h2o2458.5CP, SERPINA1, TLR4, G6PD
47cholesterol45 29 24 1111.5LPL, TLR4, CP, SERPINA1
48serine458.3SERPINA1, TLR4, CP, G6PD
49glucose458.0TLR4, SERPINA1, G6PD, LPL, IRS4
50lipid458.0TLR4, LPL, G6PD, CP, SERPINA1

GO Terms for genes affiliated with Boutonneuse Fever

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16Gene Ontology
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Biological processes related to Boutonneuse Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.0SERPINA1, TLR4

Products for genes affiliated with Boutonneuse Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Boutonneuse Fever

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet