MCID: BTN002
MIFTS: 40

Boutonneuse Fever malady

Infectious category

Summaries for Boutonneuse Fever

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A spotted fever that has material basis in rickettsia conorii subsp conorii, which is transmitted by dog tick (rhipicephalus sanguineus). the infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards: Boutonneuse Fever, also known as african tick typhus, is related to spotted fever and typhus, and has symptoms including fever, eschar (usually single) and regional adenopathy. An important gene associated with Boutonneuse Fever is IRS4 (insulin receptor substrate 4). The compounds thiobarbituric acid and sodium azide have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and t cells.

Wikipedia:64 Boutonneuse fever (also called Mediterranean spotted fever, fièvre boutonneuse, Kenya tick typhus,... more...

Aliases & Classifications for Boutonneuse Fever

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
boutonneuse fever:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

boutonneuse fever 8 10 49 61
african tick typhus 8 49
kenya tick typhus 8 49
marseilles fever 8 49
rickettsia conorii spotted fever 8
mediterranean boutonneuse fever 49
south african tick-bite fever 8
mediterranean spotted fever 49
african tick bite fever 61
kenya tick-bite fever 49


External Ids:

Disease Ontology8 DOID:14095
ICD9CM27 082.1
MeSH35 D001907
MESH via Orphanet36 D001907
ICD10 via Orphanet26 A77.1
SNOMED-CT via Orphanet58 186774005
UMLS via Orphanet62 C0006060

Related Diseases for Boutonneuse Fever

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1spotted fever30.7AFF2
2typhus30.6AFF2
3acute pancreatitis30.3SERPINA1, LPL, TLR4
4african tick-bite fever10.8
5cellulitis10.4
6cutaneous leishmaniasis10.4
7internuclear ophthalmoplegia10.4
8queensland tick typhus10.4
9rocky mountain spotted fever10.3
10euthyroid sick syndrome10.2
11quadriplegia10.2
12pancytopenia10.2
13japanese spotted fever10.2
14vasculitis10.2
15hypertriglyceridemia10.2
16rheumatic fever10.2
17q fever10.2
18polymyalgia rheumatica10.2
19osteoarthritis10.0G6PD
20bronchitis10.0SERPINA1
21diabetic cataract10.0G6PD
22acute myocardial infarction10.0SERPINA1
23thromboembolism10.0G6PD
24pancreatic cancer10.0SERPINA1
25iron deficiency anemia10.0G6PD
26siderosis10.0CP
27dilated cardiomyopathy10.0LPL
28ischemic heart disease10.0LPL
29alzheimer's disease10.0CP
30pulmonary emphysema10.0SERPINA1
31alpha 1-antitrypsin deficiency10.0SERPINA1
32periodontitis10.0TLR4
33viral hepatitis10.0G6PD, SERPINA1
34wilson disease10.0CP, G6PD
35malaria10.0G6PD, CP
36cholestasis10.0SERPINA1, CP
37hemochromatosis10.0CP, SERPINA1
38iron metabolism disease10.0CP, G6PD
39adult respiratory distress syndrome10.0SERPINA1, CP
40obesity10.0LPL
41nephrotic syndrome10.0SERPINA1, LPL
42pancreatitis10.0SERPINA1, LPL
43galactosemia10.0SERPINA1, CP
44hemolytic anemia10.0CP, G6PD
45prostate cancer10.0LPL
46liver cirrhosis10.0SERPINA1, CP
47pyelonephritis10.0TLR4
48pneumonia10.0TLR4, SERPINA1
49hyperglycemia10.0SERPINA1, LPL
50hypertension10.0LPL

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to boutonneuse fever

Clinical Features for Boutonneuse Fever

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 4)
  • fever
  • eschar (usually single)
  • regional adenopathy
  • maculopapular rash on extremities

Drugs & Therapeutics for Boutonneuse Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Boutonneuse Fever

Drug clinical trials:

Search ClinicalTrials for Boutonneuse Fever

Search NIH Clinical Center for Boutonneuse Fever

Search CenterWatch for Boutonneuse Fever

Genetic Tests for Boutonneuse Fever

Anatomical Context for Boutonneuse Fever

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Boutonneuse Fever:

33
Liver, Skin, T cells, Endothelial

Animal Models for Boutonneuse Fever or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Boutonneuse Fever

Sources:
51PubMed
See all sources

Articles related to Boutonneuse Fever:

(show all 42)
idTitleAuthorsYear
1
Boutonneuse fever and climate variability. (17114701)
2006
2
Role of TLR4 receptor polymorphisms in Boutonneuse fever. (16388712)
2005
3
Boutonneuse fever in a child: a case report and overview. (15473280)
2004
4
Boutonneuse fever in Portugal: 1995-2000. Data of a state laboratory. (12800955)
2003
5
Evaluation of clinical diagnosis scores for Boutonneuse fever. (12860646)
2003
6
The acute phase response in Sicilian patients with boutonneuse fever admitted to hospitals in Palermo, 1992-1997. (11243751)
2001
7
Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii. (10886788)
2000
8
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever. (10444262)
1999
9
Clinical and laboratory findings of boutonneuse fever in Sicilian children. (9667405)
1998
10
Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. (9528898)
1998
11
Alteration of interleukin-2 (IL-2) and soluble IL-2 receptor secretion in the sera and urine of patients with rickettsial boutonneuse fever. (8985208)
1997
12
Malignant boutonneuse fever and polymyalgia rheumatica: a coincidental association? (9334871)
1997
13
Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. (8896508)
1996
14
Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. (8059165)
1994
15
High levels of interferon-gamma in boutonneuse fever. (7996014)
1994
16
Changes in plasma lipoproteins in Mediterranean boutonneuse fever]. (1347656)
1992
17
Spotless boutonneuse fever. (1520773)
1992
18
Spotless boutonneuse fever. (1571413)
1992
19
Epidemiology of boutonneuse fever in western Sicily: accidental laboratory infection with a rickettsial agent isolated from a tick. (2273984)
1990
20
A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. (2106490)
1990
21
Ofloxacin in the treatment of boutonneuse fever. A preliminary report. (16312704)
1989
22
Epidemiology of boutonneuse fever in western Sicily: demonstration of multiple spotted fever group-Rickettsiae subtypes. (2779456)
1989
23
ARDS associated with boutonneuse fever. (2924629)
1989
24
Laboratory diagnosis of boutonneuse fever by enzyme-linked immunosorbent assay. (2694514)
1989
25
Pathogenesis of rickettsial eschars: the tache noire of boutonneuse fever. (3192207)
1988
26
Boutonneuse fever transmitted by conjunctival inoculation. (3236764)
1988
27
Boutonneuse fever and Rocky Mountain spotted fever are not alike. (3588121)
1987
28
Familial cases of boutonneuse fever. (3691750)
1987
29
C-reactive protein in boutonneuse fever. (3780711)
1986
30
Epidemiology of boutonneuse fever in western Sicily. Distribution and prevalence of spotted fever group rickettsial infection in dog ticks (Rhipicephalus sanguineus). (3513550)
1986
31
Epidemiology of boutonneuse fever in western Sicily: isolation of spotted fever group Rickettsiae from Rhipicephalus sanguineus (fam. Ixodidae). (3951368)
1986
32
Boutonneuse fever in American travelers. (3941277)
1986
33
Frequent occurrence of hepatic lesions in boutonneuse fever. (2874714)
1986
34
Depletion of Hageman factor in acute phase of boutonneuse fever. (3580149)
1986
35
Subclinical infections with Boutonneuse fever in western Sicily. (4031562)
1985
36
Persistence of antibodies to Rickettsia conorii after an acute attack of boutonneuse fever. (3968457)
1985
37
A sero-epidemiological survey of asymptomatic cases of Boutonneuse fever in western Sicily. (6369650)
1984
38
Vascular permeability in boutonneuse fever. (6736678)
1984
39
The histology of "taches noires" of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. (6412440)
1983
40
Boutonneuse fever. (7065712)
1982
41
Importation into the United States from Africa of Rhipicephalus simus on a boutonneuse fever patient. (7258502)
1981
42
The liver in boutonneuse fever. (4479621)
1974

Genetic Variations for Boutonneuse Fever

Expression for genes affiliated with Boutonneuse Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Boutonneuse Fever

Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for genes affiliated with Boutonneuse Fever

Compounds for genes affiliated with Boutonneuse Fever

Sources:
45Novoseek, 11DrugBank, 2BitterDB, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Boutonneuse Fever according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1thiobarbituric acid4510.0CP, G6PD
2sodium azide459.9G6PD, CP
3dehydroascorbic acid45 1110.9CP, G6PD
4alpha lipoic acid459.9SERPINA1, G6PD
5alpha tocopherol459.9LPL, G6PD
6methimazole45 2 1111.8CP, G6PD
7hypoxanthine45 11 2411.8G6PD, CP
8acetone459.8LPL, G6PD
9starch459.8LPL, G6PD
10gemfibrozil45 29 1111.8LPL, G6PD
11glibenclamide45 29 50 6012.7CP, G6PD
12lycopene45 2410.7CP, LPL
13glycerol 3-phosphate45 2410.7LPL, G6PD
14protamine459.6CP, LPL
15vitamin b12459.6CP, G6PD
16salicylic acid45 2910.6SERPINA1, G6PD
17nadph45 2410.5TLR4, G6PD
18glucose459.5SERPINA1, LPL, IRS4
19ascorbic acid45 2410.5G6PD, SERPINA1, CP
20folate459.4CP, AFF2, G6PD
21tocopherol459.4CP, LPL, G6PD
22phenobarbital45 29 1111.4G6PD, LPL, CP
23carnitine459.3CP, LPL, G6PD
24guanidine hydrochloride459.3LPL, G6PD
25betacarotene459.3LPL, CP
26thyroxine45 2410.3G6PD, LPL, CP
27epinephrine45 11 2411.3G6PD, LPL, CP
28vitamin a45 11 2411.3CP, SERPINA1, LPL
29malondialdehyde459.2CP, G6PD
30glutamine459.1CP, LPL, G6PD
31fibrinogen459.0CP, SERPINA1, TLR4
32polysaccharide458.9SERPINA1, LPL, TLR4
33carbohydrates458.9CP, LPL, TLR4
34phospholipid458.9TLR4, LPL, SERPINA1
35vitamin d458.9TLR4, LPL, CP
36superoxide45 249.8CP, G6PD, TLR4
37arachidonic acid45 29 11 2411.8SERPINA1, LPL, TLR4
38iron45 249.8TLR4, SERPINA1, CP
39estrogen458.8G6PD, LPL, SERPINA1, CP
40h2o2458.7CP, SERPINA1, G6PD, TLR4
41lactate458.5TLR4, G6PD, LPL, CP
42cholesterol45 29 11 2411.4TLR4, LPL, SERPINA1, CP
43lipid458.1TLR4, G6PD, LPL, SERPINA1, CP

GO Terms for genes affiliated with Boutonneuse Fever

Products for genes affiliated with Boutonneuse Fever

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Boutonneuse Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet