MCID: BVN001
MIFTS: 39

Bovine Spongiform Encephalopathy malady

Summaries for Bovine Spongiform Encephalopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Bovine spongiform encephalopathy (BSE), commonly known as mad cow disease, is a fatal neurodegenerative... more...

MalaCards: Bovine Spongiform Encephalopathy, also known as encephalopathy, bovine spongiform, is related to scrapie and prion disease. An important gene associated with Bovine Spongiform Encephalopathy is PRND (prion protein 2 (dublet)), and among its related pathways is Passive Transport by Aquaporins. The compounds vas-a and mercury have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes.

Aliases & Classifications for Bovine Spongiform Encephalopathy

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

bovine spongiform encephalopathy 8 10
encephalopathy, bovine spongiform 60
encephalopathy bovine spongiform 44


External Ids:

Disease Ontology8 DOID:5435
SNOMED-CT56 52869003
MeSH34 D016643

Related Diseases for Bovine Spongiform Encephalopathy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bovine Spongiform Encephalopathy:



Diseases related to bovine spongiform encephalopathy

Clinical Features for Bovine Spongiform Encephalopathy

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Drugs & Therapeutics for Bovine Spongiform Encephalopathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bovine Spongiform Encephalopathy

Drug clinical trials:

Search ClinicalTrials for Bovine Spongiform Encephalopathy

Search NIH Clinical Center for Bovine Spongiform Encephalopathy

Search CenterWatch for Bovine Spongiform Encephalopathy

Genetic Tests for Bovine Spongiform Encephalopathy

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Anatomical Context for Bovine Spongiform Encephalopathy

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32MalaCards
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MalaCards organs/tissues related to Bovine Spongiform Encephalopathy:

32
Brain, Spinal cord, Testes, Bone, Cerebellum, Bone marrow, Small intestine, Skeletal muscle, Heart, Cortex, Liver, Adrenal gland, Spleen, Tonsil, Olfactory bulb, Appendix

Animal Models for Bovine Spongiform Encephalopathy or affiliated genes

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Publications for Bovine Spongiform Encephalopathy

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50PubMed
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Articles related to Bovine Spongiform Encephalopathy:

(show top 50)    (show all 490)
idTitleAuthorsYear
1
L-Type Bovine Spongiform Encephalopathy in Genetically Susceptible and Resistant Sheep: Changes in Prion Strain or Phenotypic Plasticity of the Disease-Associated Prion Protein? (24218507)
2013
2
Unique properties of the classical bovine spongiform encephalopathy strain and its emergence from H-type bovine spongiform encephalopathy substantiated by VM transmission studies. (23399901)
2013
3
Bovine spongiform encephalopathy: the effect of oral exposure dose on attack rate and incubation period in cattle - an update. (23217206)
2012
4
Persistence of the bovine spongiform encephalopathy infectious agent in sewage. (22776326)
2012
5
Bovine spongiform encephalopathy surveillance in the Republic of Korea. (23520739)
2012
6
A pilot study of the impact of bovine spongiform encephalopathy on the futures of rural youth and Canadian farming. (21218350)
2011
7
Antigen retrieval using sodium hydroxide for prion immunohistochemistry in bovine spongiform encephalopathy and scrapie. (21112058)
2011
8
Experimental bovine spongiform encephalopathy: detection of PrP(Sc) in the small intestine relative to exposure dose and age. (21388635)
2011
9
The evolution of risk perceptions related to bovine spongiform encephalopathy--Canadian consumer and producer behavior. (21218347)
2011
10
Distinct molecular signature of bovine spongiform encephalopathy prion in pigs. (20031075)
2010
11
Consumer reactions to risk information on bovine spongiform encephalopathy in Japan. (21432560)
2010
12
Molecular analysis of carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) as a candidate gene for bovine spongiform encephalopathy susceptibility. (19744145)
2010
13
Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein. (19264659)
2009
14
Brainstem auditory evoked potentials in experimentally-induced bovine spongiform encephalopathy. (19101002)
2009
15
Short communication: Allele, genotype, and haplotype data for bovine spongiform encephalopathy-resistance polymorphisms from healthy US Holstein cattle. (18096956)
2008
16
Pathogenesis of bovine spongiform encephalopathy in sheep. (18092124)
2008
17
Multivariate feature selection and hierarchical classification for infrared spectroscopy: serum-based detection of bovine spongiform encephalopathy. (17237926)
2007
18
Prions in the peripheral nerves of bovine spongiform encephalopathy-affected cattle. (17485547)
2007
19
An abattoir survey on bovine spongiform encephalopathy (BSE) in Turkey. (18198543)
2007
20
Evaluation of the effectiveness of selected measures against bovine spongiform encephalopathy (BSE) in Switzerland by use of the basic reproduction ratio R0. (17555037)
2007
21
Human prion disease hypothesis does not justify the origin of bovine spongiform encephalopathy. (16855329)
2006
22
A quantitative assessment of the risk of exposure to bovine spongiform encephalopathy via meat-and-bone meal in Japan. (16712985)
2006
23
Phenotype of disease-associated PrP accumulation in the brain of bovine spongiform encephalopathy experimentally infected sheep. (15722546)
2005
24
Bovine spongiform encephalopathy, multiple sclerosis, and creutzfeldt-jakob disease are probably autoimmune diseases evoked by Acinetobacter bacteria. (16014559)
2005
25
Highly bovine spongiform encephalopathy-sensitive transgenic mice confirm the essential restriction of infectivity to the nervous system in clinically diseased cattle. (16088845)
2005
26
An evaluation of United Kingdom environmental bovine spongiform encephalopathy risk assessment. (16639897)
2005
27
Bovine spongiform encephalopathy and Creutzfeldt-Jakob disease: background and implications for nursing practice. (15693468)
2004
28
Inactivation of the bovine-spongiform-encephalopathy (BSE) agent by the acid and alkaline processes used in the manufacture of bone gelatine. (15154846)
2004
29
Pathology and pathogenesis of bovine spongiform encephalopathy and scrapie. (15148988)
2004
30
Glycosylation deficiency at either one of the two glycan attachment sites of cellular prion protein preserves susceptibility to bovine spongiform encephalopathy and scrapie infections. (15448157)
2004
31
Subclinical bovine spongiform encephalopathy infection in transgenic mice expressing porcine prion protein. (15163699)
2004
32
Perceived risk of bovine spongiform encephalopathy and dietary behavior. (14670215)
2003
33
Brain and buffy coat transmission of bovine spongiform encephalopathy to the primate Microcebus murinus. (12084158)
2002
34
The potential size and duration of an epidemic of bovine spongiform encephalopathy in British sheep. (11719694)
2002
35
Studies of embryo transfer from cattle clinically affected by bovine spongiform encephalopathy (BSE). (11936410)
2002
36
Analysis of the risk of transmitting bovine spongiform encephalopathy through bone grafts derived from bovine bone. (11374460)
2001
37
Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease. (11485685)
2001
38
Clinical presentation of bovine spongiform encephalopathy in the Republic of Ireland. (11808659)
2001
39
Bovine spongiform encephalopathy and Creutzfeldt-Jakob disease. (11351926)
2001
40
'New variant' Creutzfeldt-Jakob disease and bovine spongiform encephalopathy. (10700223)
2000
41
Oral infection by the bovine spongiform encephalopathy prion. (10220359)
1999
42
Autoantibodies to brain components and antibodies to Acinetobacter calcoaceticus are present in bovine spongiform encephalopathy. (10569779)
1999
43
Similar signature of the prion protein in natural sheep scrapie and bovine spongiform encephalopathy-linked diseases. (10523578)
1999
44
Bovine spongiform encephalopathy in Switzerland--the past and the present. (10190210)
1999
45
Risk of transmission of agents associated with Creutzfeldt-Jakob disease and bovine spongiform encephalopathy. (10088529)
1999
46
Cost-effectiveness of bovine spongiform encephalopathy screening. (10420486)
1999
47
Severely combined immunodeficient (SCID) mice resist infection with bovine spongiform encephalopathy. (9349494)
1997
48
Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens? (9370514)
1997
49
Bovine Spongiform Encephalopathy. (10398462)
1996
50
Bovine spongiform encephalopathy. Study shows need for better communication between government and doctors. (8916718)
1996

Genetic Variations for Bovine Spongiform Encephalopathy

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Expression for genes affiliated with Bovine Spongiform Encephalopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bovine Spongiform Encephalopathy

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Pathways for genes affiliated with Bovine Spongiform Encephalopathy

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53Reactome
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Pathways related to Bovine Spongiform Encephalopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0AQP4, AQP1

Compounds for genes affiliated with Bovine Spongiform Encephalopathy

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Bovine Spongiform Encephalopathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1vas-a4410.0AQP4, AQP1
2mercury449.9AQP4, AQP1
3sucrose44 11 2411.8AQP4, AQP1, PRNP
4valine449.5PRND, PRNP, AQP1

GO Terms for genes affiliated with Bovine Spongiform Encephalopathy

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16Gene Ontology
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Cellular components related to Bovine Spongiform Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.1AQP4, HECTD2, ARIH1, MPI, PRNP, SGCG

Biological processes related to Bovine Spongiform Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1multicellular organismal water homeostasisGO:05089110.0AQP4, AQP1
2carbon dioxide transportGO:0156709.9AQP4, AQP1
3protein homooligomerizationGO:0512609.8AQP4, PRNP, PRND
4cellular copper ion homeostasisGO:0068789.7PRNP, PRND

Molecular functions related to Bovine Spongiform Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1water transmembrane transporter activityGO:00537210.0AQP4, AQP1

Products for genes affiliated with Bovine Spongiform Encephalopathy

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Bovine Spongiform Encephalopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet