MCID: BVN001
MIFTS: 39

Bovine Spongiform Encephalopathy malady

Summaries for Bovine Spongiform Encephalopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Bovine spongiform encephalopathy (BSE), commonly known as mad cow disease, is a fatal neurodegenerative... more...

MalaCards: Bovine Spongiform Encephalopathy, also known as encephalopathy, bovine spongiform, is related to scrapie and prion disease. An important gene associated with Bovine Spongiform Encephalopathy is PRND (prion protein 2 (dublet)), and among its related pathways is Passive Transport by Aquaporins. The compounds vas-a and mercury have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes.

Aliases & Classifications for Bovine Spongiform Encephalopathy

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

bovine spongiform encephalopathy 8 10
encephalopathy, bovine spongiform 60
encephalopathy bovine spongiform 44


External Ids:

Disease Ontology8 DOID:5435
SNOMED-CT56 52869003
MeSH34 D016643

Related Diseases for Bovine Spongiform Encephalopathy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bovine Spongiform Encephalopathy:



Diseases related to bovine spongiform encephalopathy

Clinical Features for Bovine Spongiform Encephalopathy

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Drugs & Therapeutics for Bovine Spongiform Encephalopathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bovine Spongiform Encephalopathy

Drug clinical trials:

Search ClinicalTrials for Bovine Spongiform Encephalopathy

Search NIH Clinical Center for Bovine Spongiform Encephalopathy

Search CenterWatch for Bovine Spongiform Encephalopathy

Genetic Tests for Bovine Spongiform Encephalopathy

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Anatomical Context for Bovine Spongiform Encephalopathy

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32MalaCards
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MalaCards organs/tissues related to Bovine Spongiform Encephalopathy:

32
Brain, Spinal cord, Testes, Bone, Cerebellum, Small intestine, Skeletal muscle, Heart, Bone marrow, Spleen, Liver, Adrenal gland, Tonsil, Appendix, Cortex, Olfactory bulb

Animal Models for Bovine Spongiform Encephalopathy or affiliated genes

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Publications for Bovine Spongiform Encephalopathy

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50PubMed
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Articles related to Bovine Spongiform Encephalopathy:

(show top 50)    (show all 490)
idTitleAuthorsYear
1
Presence of subclinical infection in gene-targeted human prion protein transgenic mice exposed to atypical bovine spongiform encephalopathy. (24045112)
2013
2
Quantitative analysis of wet-heat inactivation in bovine spongiform encephalopathy. (23376069)
2013
3
Disease characteristics of bovine spongiform encephalopathy following inoculation into mice via three different routes. (24020404)
2013
4
Rapid assessment of bovine spongiform encephalopathy prion inactivation by heat treatment in yellow grease produced in the industrial manufacturing process of meat and bone meals. (23835086)
2013
5
Ultrastructural findings in pigs experimentally infected with bovine spongiform encephalopathy agent. (22505368)
2012
6
Minimal involvement of the circumventricular organs in the pathogenesis of spontaneously arising and experimentally induced classical bovine spongiform encephalopathy. (22516087)
2012
7
Individual factors associated with L- and H-type Bovine Spongiform encephalopathy in France. (22647660)
2012
8
Case-control study of cases of bovine spongiform encephalopathy born after July 31, 1996 (BARB cases) in Great Britain. (22262699)
2012
9
PRNP and SPRN genes polymorphism in atypical bovine spongiform encephalopathy cases diagnosed in Polish cattle. (22723200)
2012
10
Effect of PrP genotype and route of inoculation on the ability of discriminatory Western blot to distinguish scrapie from sheep bovine spongiform encephalopathy. (21994325)
2012
11
Prion in saliva of bovine spongiform encephalopathy-infected cattle. (23171518)
2012
12
Bovine spongiform encephalopathy infection alters endogenous retrovirus expression in distinct brain regions of cynomolgus macaques (Macaca fascicularis). (21699683)
2011
13
Bovine spongiform encephalopathy: investigation of phenotypic variation among passive surveillance cases. (21145564)
2011
14
Examination of the offspring of a Japanese cow affected with L-type bovine spongiform encephalopathy. (20805640)
2011
15
Bovine spongiform encephalopathy associated insertion/deletion polymorphisms of the prion protein gene in the four beef cattle breeds from North China. (21923635)
2011
16
Descriptive epidemiological features of cases of bovine spongiform encephalopathy born after July 31, 1996 in Great Britain. (20729514)
2010
17
Pathogenesis of experimental bovine spongiform encephalopathy (BSE): estimation of tissue infectivity according to incubation period. (18950589)
2009
18
Bovine spongiform encephalopathy and aquaculture. (19363268)
2009
19
An advantageous method utilizing new homogenizing device BioMasher and a sensitive ELISA to detect bovine spongiform encephalopathy accurately in brain tissue. (18346796)
2008
20
Stress response in the central nervous system of a transgenic mouse model of bovine spongiform encephalopathy. (17692544)
2008
21
Cases of bovine spongiform encephalopathy born in Switzerland before and after the ban on the use of bovine specified risk material in feed. (17237456)
2007
22
Accumulation of mono-glycosylated form-rich, plaque-forming PrPSc in the second atypical bovine spongiform encephalopathy case in Japan. (17881874)
2007
23
Time-course studies of 14-3-3 protein isoforms in cerebrospinal fluid and brain of primates after oral or intracerebral infection with bovine spongiform encephalopathy agent. (18024918)
2007
24
Sheep-passaged bovine spongiform encephalopathy agent exhibits altered pathobiological properties in bovine-PrP transgenic mice. (17079295)
2007
25
A bovine prion acquires an epidemic bovine spongiform encephalopathy strain-like phenotype on interspecies transmission. (17596445)
2007
26
Comparison of three monoclonal antibodies for use in immunohistochemical detection of bovine spongiform encephalopathy protease-resistant prion protein. (16566267)
2006
27
Bovine spongiform encephalopathy in Japan: history and recent studies on oxidative stress in prion diseases. (16924141)
2006
28
On the question of sporadic or atypical bovine spongiform encephalopathy and Creutzfeldt-Jakob disease. (17326930)
2006
29
Primary isolation of the bovine spongiform encephalopathy agent in mice: agent definition based on a review of 150 transmissions. (15737338)
2005
30
Tissue distribution of bovine spongiform encephalopathy infectivity in Romney sheep up to the onset of clinical disease after oral challenge. (15747655)
2005
31
Bov-tA short interspersed nucleotide element sequences in circulating nucleic acids from sera of cattle with bovine spongiform encephalopathy (BSE) and sera of cattle exposed to BSE. (16002628)
2005
32
DNA polymorphisms of the prion doppel gene region in four different German cattle breeds and cows tested positive for bovine spongiform encephalopathy. (16284804)
2005
33
Bovine spongiform encephalopathy and its relationship to the variant form of Creutzfeldt-Jakob disease. (15077408)
2004
34
Bovine spongiform encephalopathy (BSE): the end of the beginning or the beginning of the end? (15449460)
2004
35
Predicting incidence of variant Creutzfeldt-Jakob disease from UK dietary exposure to bovine spongiform encephalopathy for the 1940 to 1969 and post-1969 birth cohorts. (14559750)
2003
36
Neuropathological characterisation of French bovine spongiform encephalopathy cases. (14624299)
2003
37
Detection of bovine spongiform encephalopathy, ovine scrapie prion-related protein (PrPSc) and normal PrPc by monoclonal antibodies raised to copper-refolded prion protein. (12429022)
2003
38
Bovine spongiform encephalopathy (BSE) and its epidemiology. (14522859)
2003
39
Guest Editorial: Managing Bovine Spongiform Encephalopathy Risk in the United States. (11984425)
2002
40
Studies on the removal of a bovine spongiform encephalopathy-derived agent by processes used in the manufacture of human immunoglobulin. (12201843)
2002
41
Plasma metabolites indicate energy metabolism disruption during the preclinical phase of bovine spongiform encephalopathy infection. (12204641)
2002
42
Diagnosis of bovine spongiform encephalopathy: a review. (11087129)
2000
43
Temporal aspects of the epidemic of bovine spongiform encephalopathy in Great Britain: holding-associated risk factors for the disease. (11058020)
2000
44
Modelling the expected numbers of preclinical and clinical cases of bovine spongiform encephalopathy in Switzerland. (10466772)
1999
45
Creutzfeldt-Jakob disease, new variant creutzfeldt-jakob disease, and bovine spongiform encephalopathy. (10517931)
1999
46
New variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy. (9494833)
1998
47
Bovine spongiform encephalopathy. (9503105)
1998
48
The emergence of bovine spongiform encephalopathy and related diseases. (9716952)
1998
49
Studies on the efficacy of hyperbaric rendering procedures in inactivating bovine spongiform encephalopathy (BSE) and scrapie agents. (9612912)
1998
50
Separating the environmental and genetic factors that may be causes of bovine spongiform encephalopathy. (8856808)
1996

Genetic Variations for Bovine Spongiform Encephalopathy

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Expression for genes affiliated with Bovine Spongiform Encephalopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bovine Spongiform Encephalopathy

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Pathways for genes affiliated with Bovine Spongiform Encephalopathy

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53Reactome
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Pathways related to Bovine Spongiform Encephalopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0AQP4, AQP1

Compounds for genes affiliated with Bovine Spongiform Encephalopathy

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Bovine Spongiform Encephalopathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1vas-a4410.0AQP1, AQP4
2mercury449.9AQP1, AQP4
3sucrose44 11 2411.8AQP1, AQP4, PRNP
4valine449.5AQP1, PRND, PRNP

GO Terms for genes affiliated with Bovine Spongiform Encephalopathy

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16Gene Ontology
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Cellular components related to Bovine Spongiform Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.1AQP4, HECTD2, ARIH1, MPI, PRNP, SGCG

Biological processes related to Bovine Spongiform Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1multicellular organismal water homeostasisGO:05089110.0AQP4, AQP1
2carbon dioxide transportGO:0156709.9AQP4, AQP1
3protein homooligomerizationGO:0512609.8AQP4, PRNP, PRND
4cellular copper ion homeostasisGO:0068789.7PRNP, PRND

Molecular functions related to Bovine Spongiform Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1water transmembrane transporter activityGO:00537210.0AQP4, AQP1

Products for genes affiliated with Bovine Spongiform Encephalopathy

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  • Antibodies
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Sources for Bovine Spongiform Encephalopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet