BP
MCID: BWN003
MIFTS: 45

Bowenoid Papulosis (BP) malady

Rare diseases category
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Summaries for Bowenoid Papulosis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Bowenoid papulosis is a cutaneous condition characterized by the presence of pigmented verrucous papules... more...

MalaCards: Bowenoid Papulosis, also known as BP, is related to papilloma and cervical intraepithelial neoplasia. An important gene associated with Bowenoid Papulosis is FLG (filaggrin), and among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Regulation of Telomerase. The compounds olomoucine and indomethacine have been mentioned in the context of this disorder. Affiliated tissues include skin, cervix and tongue, and related mouse phenotypes are vision/eye and embryogenesis.

Aliases & Classifications for Bowenoid Papulosis

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

bowenoid papulosis 43 62
bp 43


Related Diseases for Bowenoid Papulosis

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17GeneCards, 18GeneDecks
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Diseases related to Bowenoid Papulosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma30.7CDKN2A, FLG
2cervical intraepithelial neoplasia30.5TERT, CDKN2A
3breast cancer30.0PPARG, TERT, PTGS2, CCNE1, CCND1, CDKN2A
4rheumatoid arthritis29.7TERT, PTGS2, FLG
5oral cancer29.7TERT, PTGS2, CCND1, CDKN2A
6burkitt's lymphoma29.6CDKN2A, CCND1, CCNE1
7cervicitis10.5
8bullous pemphigoid10.5
9acquired immunodeficiency syndrome10.4
10hypertension10.4
11endotheliitis10.3
12atopic dermatitis10.2
13systemic lupus erythematosus10.2
14dermatitis10.2
15eosinophilia10.2
16hairy cell leukemia10.2
17in situ carcinoma10.2
18leukemia10.2
19lupus erythematosus10.2
20cystitis10.2
21paine syndrome10.2
22chronic interstitial cystitis10.2
23thalassemia10.2
24alzheimer's disease10.2
25teratoma10.1TERT
26coronary artery disease10.1
27artery disease10.1
28essential hypertension10.1
29obesity10.1
30schizophrenia10.1
31malignant peripheral nerve sheath tumor10.1CDKN2A, TERT
32thyroid cancer, anaplastic10.0TERT, PPARG
33laryngeal benign neoplasm10.0CCND1, TERT
34nasopharynx carcinoma10.0CDKN2A, TERT
35rheumatic disease10.0FLG, PTGS2
36esophageal cancer10.0CDKN2A, CCND1
37pancreatic cancer10.0TERT, CCND1
38papillary thyroid carcinoma10.0CCND1, PPARG
39cholangiocarcinoma10.0TERT, PTGS2
40pulmonary fibrosis10.0PPARG, TERT
41bladder carcinoma10.0CDKN2A, TERT
42multiple myeloma10.0CDKN2A, CCND1
43laryngeal squamous cell carcinoma10.0CDKN2A, CCND1, TERT
44alpha thalassemia10.0
45neuronitis10.0
46chronic granulomatous disease10.0
47dilated cardiomyopathy10.0
48migraine10.0
49prostatitis10.0
50neurologic diseases10.0

Graphical network of the top 20 diseases related to Bowenoid Papulosis:



Diseases related to bowenoid papulosis

Symptoms for Bowenoid Papulosis

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Drugs & Therapeutics for Bowenoid Papulosis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Bowenoid Papulosis

Search NIH Clinical Center for Bowenoid Papulosis

Genetic Tests for Bowenoid Papulosis

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Anatomical Context for Bowenoid Papulosis

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33MalaCards
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MalaCards organs/tissues related to Bowenoid Papulosis:

33
Skin, Cervix, Tongue

Animal Models for Bowenoid Papulosis or affiliated genes

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37MGI
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Publications for Bowenoid Papulosis

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52PubMed
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Articles related to Bowenoid Papulosis:

(show top 50)    (show all 131)
idTitleAuthorsYear
1
Extensive bowenoid papulosis of the vulva treated by carbon dioxide laser in a patient with AIDS. (23347880)
2013
2
Spontaneous regression of bowenoid papulosis. (24011282)
2013
3
Periungual bowenoid papulosis due to human papillomavirus type 42. (23375694)
2013
4
Bowenoid Papulosis of the Vulva and Subsequent Periungual Bowen's Disease Induced by the Same Mucosal HPVs. (22148018)
2011
5
What is your diagnosis? Bowenoid papulosis. (21284277)
2010
6
Isolated extragenital bowenoid papulosis of the toe-webs. (19326023)
2009
7
Expression of p16 and hTERT protein is associated with the presence of high-risk human papillomavirus in Bowenoid papulosis. (16919029)
2006
8
Detection of mucosal human papilloma virus DNA in bowenoid papulosis, Bowen's disease and squamous cell carcinoma of the skin. (16700665)
2006
9
Morphometric assessment of nuclei in Bowen's disease and bowenoid papulosis. (14731252)
2004
10
A case of Bowenoid papulosis of the penis successfully treated with topical imiquimod cream 5%. (15601490)
2004
11
Successful treatment of bowenoid papulosis in a 9-year-old girl with vertically acquired human immunodeficiency virus. (12837910)
2003
12
Photodynamic therapy for bowenoid papulosis using a novel incoherent light-emitting diode device. (14674917)
2003
13
Detection of human papillomavirus type 16 in bowenoid papulosis and nonbowenoid tissues. (12786880)
2003
14
Bowenoid papulosis. (12545128)
2003
15
Isolated human papillomavirus 18-positive extragenital bowenoid papulosis and idiopathic CD4+ lymphocytopenia. (11260028)
2001
16
Treatment of a bowenoid papulosis of the penis with local applications of cidofovir in a patient with acquired immunodeficiency syndrome. (11606156)
2001
17
Successful topical immunotherapy of bowenoid papulosis with imiquimod. (11899127)
2001
18
The presence of HPV types 6/11, 16/18, 31/33/51 in Bowenoid papulosis demonstrated by DNA in situ hybridization. (11138919)
2000
19
Development of squamous cell carcinoma by two high-risk human papillomaviruses (HPVs), a novel HPV-67 and HPV-31 from bowenoid papulosis. (10971337)
2000
20
Facial bowenoid papulosis secondary to human papillomavirus type 16. (10233343)
1999
21
Bowenoid papulosis showing polyclonal nature. (9785012)
1998
22
Bowenoid papulosis turning to squamous cell carcinoma. (20921709)
1998
23
Bowen's disease and Bowenoid papulosis of the vulva. (7789604)
1995
24
The presence of HPV types 6/11, 13, 16 and 33 in bowenoid papulosis in an HIV-positive male, demonstrated by DNA in situ hybridization. (1648931)
1991
25
Linear bowenoid papulosis of the genitalia. A possible Koebner phenomenon. (2397968)
1990
26
Bowenoid papulosis. (2182038)
1990
27
Efficacy of interferons on bowenoid papulosis and other precancerous lesions. (1701802)
1990
28
Cervical intraepithelial neoplasia III in an adolescent with Bowenoid papulosis. (2175743)
1990
29
Human papillomavirus infection and filaggrin expression in paraffin-embedded biopsy specimens of extragenital Bowen's disease and genital bowenoid papulosis. (2164515)
1990
30
Detection of human papillomavirus type 16 DNA and papillomavirus genus-specific antigens in vulva and cervix from patients with Bowenoid papulosis. (2540130)
1989
31
Immunosuppression in men with bowenoid papulosis. (2565705)
1989
32
Bowenoid papulosis of the penis: successful management with neodymium:YAG laser. (3373609)
1988
33
Detection of human papillomavirus type 16 in bowenoid papulosis and invasive carcinoma occurring in the same patient with a history of cervical carcinoma. (2837151)
1988
34
Bowenoid papulosis. (3026758)
1987
35
Human papillomavirus type 16 in bowenoid papulosis, intraoral papillomas, and squamous cell carcinoma of the tongue. (3028282)
1987
36
Bowenoid papulosis: clinical and histological study of eight cases. (3034760)
1987
37
Bowenoid papulosis in a penile epidermal inclusion cyst. (3828216)
1987
38
Bowenoid papulosis of the male and female genitalia: risk of cervical neoplasia. (3007587)
1986
39
Bowenoid papulosis in three-year-old girl. (3950132)
1986
40
Bowenoid papulosis of the genitalia associated with human papillomavirus DNA type 16 in an infant with atopic dermatitis. (2989808)
1985
41
HPV-16-related Bowenoid papulosis. (2861521)
1985
42
Papillomavirus common antigens. Papillomavirus antigen in verruca, benign papillomatous lesions, trichilemmoma, and bowenoid papulosis: an immunoperoxidase study. (6329106)
1984
43
Bowenoid papulosis of the chin. (6491022)
1984
44
Human papillomavirus type-16-related DNA in genital Bowen's disease and in Bowenoid papulosis. (6315601)
1983
45
Bowenoid papulosis in the perianal region. (6593959)
1983
46
Etretinate in bowenoid papulosis. (6118745)
1981
47
Bowenoid papulosis: a review. (7009074)
1981
48
Bowenoid papulosis of the penis. (7398133)
1980
49
Bowenoid papulosis of the penis. Demonstration of intranuclear viral-like particles. (7468932)
1980
50
Bowenoid papulosis. (549498)
1979

Variations for Bowenoid Papulosis

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Expression for genes affiliated with Bowenoid Papulosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bowenoid Papulosis

Search GEO for disease gene expression data for Bowenoid Papulosis.

Pathways for genes affiliated with Bowenoid Papulosis

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50PathCards, 38NCBI BioSystems Database, 30KEGG, 51PharmGKB, 53QIAGEN, 60Thomson Reuters, 55Reactome, 5Cell Signaling Technology
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Pathways related to Bowenoid Papulosis according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TERT, CCND1
29.5CCND1, TERT
3
Show member pathways
9.5CCND1, CDKN2A
49.4CCND1, PPARG
5
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.3PTGS2, PPARG
69.3PTGS2, PPARG
79.3CCND1, PTGS2
89.2CCNE1, TERT
99.1PPARG, CCNE1
109.1CCND1, CCNE1
119.1CCND1, CCNE1
12
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.1CCNE1, CCND1
13
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.1CCNE1, CCND1
149.1CCND1, CCNE1
159.1CCND1, CCNE1
169.1CCND1, CCNE1
17
Show member pathways
9.1CCNE1, CCND1
18
Show member pathways
9.1CDKN2A, TERT, PPARG
199.1CDKN2A, CCND1, TERT
208.7CDKN2A, CCND1, CCNE1
21
Show member pathways
DNA damage response38
8.7CCNE1, CCND1, CDKN2A
22
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
8.7CDKN2A, CCND1, CCNE1
23
Show member pathways
Cell cycle38
8.7CDKN2A, CCND1, CCNE1
24
Show member pathways
8.7CCNE1, CCND1, CDKN2A
25
Show member pathways
8.7CCNE1, CCND1, CDKN2A
26
Show member pathways
Signaling Pathways in Glioblastoma38
8.7CDKN2A, CCND1, CCNE1
278.7CDKN2A, CCND1, CCNE1
28
Show member pathways
8.7CCNE1, CCND1, CDKN2A
298.5CCND1, CCNE1, PTGS2
308.5PTGS2, CCNE1, CCND1
31
Show member pathways
8.3TERT, CCNE1, CCND1, CDKN2A
32
Show member pathways
8.1PTGS2, CCNE1, CCND1, CDKN2A
338.1PTGS2, CCNE1, CCND1, CDKN2A
34
Show member pathways
8.1PTGS2, CCNE1, CCND1, CDKN2A
357.5CDKN2A, CCND1, CCNE1, PTGS2, PPARG

Compounds for genes affiliated with Bowenoid Papulosis

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Bowenoid Papulosis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1olomoucine45 1110.8CDKN2A, CCND1
2indomethacine459.8PPARG, PTGS2
3bexarotene45 29 1111.8CCND1, PPARG
4r-flurbiprofen459.7CCND1, PTGS2
5balsalazide45 1110.7PTGS2, PPARG
6nimesulide45 1110.7PTGS2, PPARG
7cyclopentenone459.7PTGS2, PPARG
8p00001459.7CDKN2A, CCND1
9nickel45 2410.6CDKN2A, FLG
10gw966245 2910.6PPARG, PTGS2
11etodolac45 1110.6CCND1, PTGS2
12thiazolidinedione459.6CCND1, PPARG
13crcs459.6CCND1, CDKN2A
14depsipeptide459.5CDKN2A, CCND1, TERT
15thymidylate459.5CDKN2A, CCND1, TERT
16adriamycin459.5CDKN2A, CCND1, TERT
17nicotine45 29 51 1112.5FLG, CCND1, CDKN2A
18arsenite45 2410.4CDKN2A, CCND1, TERT
19retinoid459.3CCND1, FLG, PPARG
20ns 39845 6110.3CCND1, PTGS2
21butyrate459.3CDKN2A, CCND1, TERT
22paclitaxel45 51 1111.3CDKN2A, CCND1, TERT
23exisulind459.3CCND1, PTGS2, PPARG
24rofecoxib45 51 29 1112.2PPARG, PTGS2, CCND1
25sulindac sulfide459.2CCND1, PTGS2, PPARG
26ciglitazone45 2910.2CCND1, PTGS2, PPARG
27sulindac45 1110.2CCND1, PTGS2, PPARG
28rapamycin459.2PPARG, TERT, CCND1
2915-deoxy-delta-12,14-prostaglandin j2459.2PPARG, PTGS2, CCND1
30celecoxib45 61 29 51 24 1114.2PPARG, PTGS2, CCND1
31resveratrol45 61 24 1112.2CCND1, PTGS2, PPARG
32troglitazone45 29 61 1112.2PPARG, PTGS2, CCND1
33curcumin459.2PPARG, PTGS2, CCND1
34sb 20358045 6110.1PPARG, PTGS2, CCND1
35pd 98,059459.0CCND1, PTGS2, TERT
36sulfasalazine29 45 51 1112.0PTGS2, PPARG
37doxorubicin45 51 1111.0TERT, CCND1, CDKN2A
38testosterone45 61 24 1111.9CDKN2A, CCND1, TERT, PPARG
39nitric oxide45 24 1110.9CDKN2A, FLG, PTGS2, TERT
40egcg458.9CDKN2A, CCND1, PTGS2, TERT
41gf 109203x45 619.9PPARG, PTGS2, FLG, CCND1
42cisplatin45 51 61 1111.9TERT, PTGS2, CCND1, CDKN2A
43ly294002458.8CCND1, PTGS2, TERT, PPARG
44cycloheximide458.7PPARG, PTGS2, CCND1, CDKN2A
45retinoic acid45 249.6PPARG, TERT, FLG, CCND1, CDKN2A
46n acetylcysteine458.4CDKN2A, CCND1, PTGS2, TERT, PPARG
47genistein45 29 61 3 24 1113.4PPARG, TERT, PTGS2, CCND1, CDKN2A
48vegf458.4PPARG, TERT, PTGS2, CCND1, CDKN2A
49serine458.3TERT, FLG, CCNE1, CCND1, CDKN2A
50estrogen457.6PPARG, TERT, PTGS2, CCNE1, CCND1, CDKN2A

GO Terms for genes affiliated with Bowenoid Papulosis

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16Gene Ontology
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Cellular components related to Bowenoid Papulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:0003078.8CCNE1, CCND1
2nucleolusGO:0057308.3CDKN2A, CCND1, CCNE1, TERT
3nucleoplasmGO:0056547.6CDKN2A, CCND1, CCNE1, TERT, PPARG

Biological processes related to Bowenoid Papulosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.9CDKN2A, TERT
2organ regenerationGO:0311009.6CCND1, PPARG
3brown fat cell differentiationGO:0508739.5PPARG, PTGS2
4response to estrogenGO:0436279.5CCND1, PPARG
5regulation of blood pressureGO:0082179.3PTGS2, PPARG
6activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.2CDKN2A, PPARG
7cell divisionGO:0513019.1CCND1, CCNE1
8response to drugGO:0424939.0CCND1, PTGS2, PPARG
9G1/S transition of mitotic cell cycleGO:0000828.9CDKN2A, CCND1, CCNE1
10mitotic cell cycleGO:0002788.8CCNE1, CCND1, CDKN2A
11positive regulation of transcription, DNA-templatedGO:0458938.6PPARG, CCNE1, CDKN2A

Molecular functions related to Bowenoid Papulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase regulator activityGO:0165389.0CCND1, CCNE1
2protein kinase bindingGO:0199018.7CDKN2A, CCND1, CCNE1
3enzyme bindingGO:0198998.5CCND1, PTGS2, PPARG

Products for genes affiliated with Bowenoid Papulosis

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Sources for Bowenoid Papulosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet