BP
MCID: BWN003
MIFTS: 46

Bowenoid Papulosis (BP) malady

Rare diseases category
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Summaries for Bowenoid Papulosis

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Wikipedia:65 Bowenoid papulosis is a cutaneous condition characterized by the presence of pigmented verrucous papules... more...

MalaCards based summary: Bowenoid Papulosis, also known as BP, is related to papilloma and cervical intraepithelial neoplasia. An important gene associated with Bowenoid Papulosis is FLG (filaggrin), and among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Regulation of Telomerase. The compounds olomoucine and indomethacine have been mentioned in the context of this disorder. Affiliated tissues include skin, cervix and tongue, and related mouse phenotypes are vision/eye and embryogenesis.

Aliases & Classifications for Bowenoid Papulosis

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Bowenoid Papulosis, Aliases & Descriptions:

Name: Bowenoid Papulosis 42 62
 
Bp 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Bowenoid Papulosis

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Diseases related to Bowenoid Papulosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma30.9FLG, CDKN2A
2cervical intraepithelial neoplasia30.7TERT, CDKN2A
3colitis29.7PTGS2, PPARG
4rheumatoid arthritis29.7TERT, FLG, PTGS2
5oral cancer29.5TERT, PTGS2, CCND1, CDKN2A
6burkitt's lymphoma29.1CDKN2A, CCND1, CCNE1
7breast cancer29.1CDKN2A, CCNE1, PTGS2, PPARG, CCND1, TERT
8cervicitis10.6
9bullous pemphigoid10.5
10teratoma10.4TERT
11acquired immunodeficiency syndrome10.4
12hypertension10.4
13endotheliitis10.3
14cystitis10.3
15leukemia10.3
16systemic lupus erythematosus10.3
17atopic dermatitis10.3
18dermatitis10.3
19eosinophilia10.3
20hairy cell leukemia10.3
21in situ carcinoma10.3
22lupus erythematosus10.3
23malignant peripheral nerve sheath tumor10.2TERT, CDKN2A
24thalassemia10.2
25chronic interstitial cystitis10.2
26thyroid cancer, anaplastic10.2PPARG, TERT
27laryngeal benign neoplasm10.2CCND1, TERT
28nasopharynx carcinoma10.2TERT, CDKN2A
29alzheimer's disease10.2
30schizophrenia10.2
31rheumatic disease10.2FLG, PTGS2
32esophageal cancer10.2CCND1, CDKN2A
33pancreatic cancer10.1CCND1, TERT
34pulmonary fibrosis10.1PPARG, TERT
35papillary thyroid carcinoma10.1CCND1, PPARG
36cholangiocarcinoma10.1TERT, PTGS2
37obesity10.1
38artery disease10.1
39essential hypertension10.1
40bladder carcinoma10.1TERT, CDKN2A
41multiple myeloma10.1CCND1, CDKN2A
42laryngeal squamous cell carcinoma10.0CDKN2A, TERT, CCND1
43malignant glioma10.0TERT, CCND1, CDKN2A
44endometrial carcinoma10.0CDKN2A, CCND1, TERT
45chronic granulomatous disease10.0
46dilated cardiomyopathy10.0
47gastric cancer10.0
48alpha thalassemia10.0
49neuronitis10.0
50melanoma10.0

Graphical network of the top 20 diseases related to Bowenoid Papulosis:



Diseases related to bowenoid papulosis

Symptoms for Bowenoid Papulosis

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Drugs & Therapeutics for Bowenoid Papulosis

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Drug clinical trials:

Search ClinicalTrials for Bowenoid Papulosis

Search NIH Clinical Center for Bowenoid Papulosis

Genetic Tests for Bowenoid Papulosis

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Anatomical Context for Bowenoid Papulosis

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MalaCards organs/tissues related to Bowenoid Papulosis:

32
Skin, Cervix, Tongue

Animal Models for Bowenoid Papulosis or affiliated genes

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Publications for Bowenoid Papulosis

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Articles related to Bowenoid Papulosis:

(show top 50)    (show all 135)
idTitleAuthorsYear
1
Dermoscopic findings in bowenoid papulosis: report of two cases. (25396088)
2014
2
Extensive bowenoid papulosis of the vulva treated by carbon dioxide laser in a patient with AIDS. (23347880)
2013
3
Spontaneous regression of bowenoid papulosis. (24011282)
2013
4
Periungual bowenoid papulosis due to human papillomavirus type 42. (23375694)
2013
5
Bowenoid Papulosis of the Vulva and Subsequent Periungual Bowen's Disease Induced by the Same Mucosal HPVs. (22148018)
2011
6
What is your diagnosis? Bowenoid papulosis. (21284277)
2010
7
Isolated extragenital bowenoid papulosis of the toe-webs. (19326023)
2009
8
Expression of p16 and hTERT protein is associated with the presence of high-risk human papillomavirus in Bowenoid papulosis. (16919029)
2006
9
Detection of mucosal human papilloma virus DNA in bowenoid papulosis, Bowen's disease and squamous cell carcinoma of the skin. (16700665)
2006
10
Morphometric assessment of nuclei in Bowen's disease and bowenoid papulosis. (14731252)
2004
11
A case of Bowenoid papulosis of the penis successfully treated with topical imiquimod cream 5%. (15601490)
2004
12
Successful treatment of bowenoid papulosis in a 9-year-old girl with vertically acquired human immunodeficiency virus. (12837910)
2003
13
Photodynamic therapy for bowenoid papulosis using a novel incoherent light-emitting diode device. (14674917)
2003
14
Detection of human papillomavirus type 16 in bowenoid papulosis and nonbowenoid tissues. (12786880)
2003
15
Bowenoid papulosis. (12545128)
2003
16
Isolated human papillomavirus 18-positive extragenital bowenoid papulosis and idiopathic CD4+ lymphocytopenia. (11260028)
2001
17
Treatment of a bowenoid papulosis of the penis with local applications of cidofovir in a patient with acquired immunodeficiency syndrome. (11606156)
2001
18
Successful topical immunotherapy of bowenoid papulosis with imiquimod. (11899127)
2001
19
The presence of HPV types 6/11, 16/18, 31/33/51 in Bowenoid papulosis demonstrated by DNA in situ hybridization. (11138919)
2000
20
Development of squamous cell carcinoma by two high-risk human papillomaviruses (HPVs), a novel HPV-67 and HPV-31 from bowenoid papulosis. (10971337)
2000
21
Facial bowenoid papulosis secondary to human papillomavirus type 16. (10233343)
1999
22
Bowenoid papulosis showing polyclonal nature. (9785012)
1998
23
Bowenoid papulosis turning to squamous cell carcinoma. (20921709)
1998
24
Bowen's disease and Bowenoid papulosis of the vulva. (7789604)
1995
25
The presence of HPV types 6/11, 13, 16 and 33 in bowenoid papulosis in an HIV-positive male, demonstrated by DNA in situ hybridization. (1648931)
1991
26
Bowenoid papulosis. (1848870)
1991
27
Linear bowenoid papulosis of the genitalia. A possible Koebner phenomenon. (2397968)
1990
28
Bowenoid papulosis. (2182038)
1990
29
Efficacy of interferons on bowenoid papulosis and other precancerous lesions. (1701802)
1990
30
Cervical intraepithelial neoplasia III in an adolescent with Bowenoid papulosis. (2175743)
1990
31
Human papillomavirus infection and filaggrin expression in paraffin-embedded biopsy specimens of extragenital Bowen's disease and genital bowenoid papulosis. (2164515)
1990
32
Detection of human papillomavirus type 16 DNA and papillomavirus genus-specific antigens in vulva and cervix from patients with Bowenoid papulosis. (2540130)
1989
33
Bowenoid papulosis of the penis: successful management with neodymium:YAG laser. (3373609)
1988
34
Detection of human papillomavirus type 16 in bowenoid papulosis and invasive carcinoma occurring in the same patient with a history of cervical carcinoma. (2837151)
1988
35
Bowenoid papulosis. (3026758)
1987
36
Human papillomavirus type 16 in bowenoid papulosis, intraoral papillomas, and squamous cell carcinoma of the tongue. (3028282)
1987
37
Bowenoid papulosis: clinical and histological study of eight cases. (3034760)
1987
38
Bowenoid papulosis in a penile epidermal inclusion cyst. (3828216)
1987
39
Bowenoid papulosis of the male and female genitalia: risk of cervical neoplasia. (3007587)
1986
40
Bowenoid papulosis of the genitalia associated with human papillomavirus DNA type 16 in an infant with atopic dermatitis. (2989808)
1985
41
HPV-16-related Bowenoid papulosis. (2861521)
1985
42
Papillomavirus common antigens. Papillomavirus antigen in verruca, benign papillomatous lesions, trichilemmoma, and bowenoid papulosis: an immunoperoxidase study. (6329106)
1984
43
Bowenoid papulosis of the chin. (6491022)
1984
44
Human papillomavirus type-16-related DNA in genital Bowen's disease and in Bowenoid papulosis. (6315601)
1983
45
Bowenoid papulosis in the perianal region. (6593959)
1983
46
Etretinate in bowenoid papulosis. (6118745)
1981
47
Bowenoid papulosis: a review. (7009074)
1981
48
Bowenoid papulosis of the penis. (7398133)
1980
49
Bowenoid papulosis of the penis. Demonstration of intranuclear viral-like particles. (7468932)
1980
50
Bowenoid papulosis. (549498)
1979

Variations for Bowenoid Papulosis

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Expression for genes affiliated with Bowenoid Papulosis

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Expression patterns in normal tissues for genes affiliated with Bowenoid Papulosis

Search GEO for disease gene expression data for Bowenoid Papulosis.

Pathways for genes affiliated with Bowenoid Papulosis

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Pathways related to Bowenoid Papulosis according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TERT, CCND1
29.5CCND1, TERT
3
Show member pathways
9.5CCND1, CDKN2A
49.4CCND1, PPARG
5
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.3PTGS2, PPARG
69.3PTGS2, PPARG
79.3CCND1, PTGS2
89.2CCNE1, TERT
99.1PPARG, CCNE1
109.1CCND1, CCNE1
119.1CCND1, CCNE1
12
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.1CCNE1, CCND1
13
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.1CCNE1, CCND1
149.1CCND1, CCNE1
159.1CCND1, CCNE1
169.1CCND1, CCNE1
17
Show member pathways
9.1CCNE1, CCND1
18
Show member pathways
9.1CDKN2A, TERT, PPARG
199.1CDKN2A, CCND1, TERT
208.7CDKN2A, CCND1, CCNE1
21
Show member pathways
DNA damage response37
8.7CCNE1, CCND1, CDKN2A
22
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
8.7CDKN2A, CCND1, CCNE1
23
Show member pathways
Cell cycle37
8.7CDKN2A, CCND1, CCNE1
24
Show member pathways
8.7CCNE1, CCND1, CDKN2A
25
Show member pathways
8.7CCNE1, CCND1, CDKN2A
26
Show member pathways
Signaling Pathways in Glioblastoma37
8.7CDKN2A, CCND1, CCNE1
278.7CDKN2A, CCND1, CCNE1
28
Show member pathways
8.7CCNE1, CCND1, CDKN2A
298.5CCND1, CCNE1, PTGS2
308.5PTGS2, CCNE1, CCND1
31
Show member pathways
8.3TERT, CCNE1, CCND1, CDKN2A
32
Show member pathways
8.1PTGS2, CCNE1, CCND1, CDKN2A
338.1PTGS2, CCNE1, CCND1, CDKN2A
34
Show member pathways
8.1PTGS2, CCNE1, CCND1, CDKN2A
357.5CDKN2A, CCND1, CCNE1, PTGS2, PPARG

Compounds for genes affiliated with Bowenoid Papulosis

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Compounds related to Bowenoid Papulosis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1olomoucine44 1110.8CDKN2A, CCND1
2indomethacine449.8PPARG, PTGS2
3bexarotene44 28 1111.8CCND1, PPARG
4r-flurbiprofen449.7CCND1, PTGS2
5balsalazide44 1110.7PTGS2, PPARG
6cyclopentenone449.7PTGS2, PPARG
7nimesulide44 1110.7PTGS2, PPARG
8p00001449.7CDKN2A, CCND1
9nickel44 2410.6CDKN2A, FLG
10gw966244 2810.6PPARG, PTGS2
11etodolac44 1110.6CCND1, PTGS2
12thiazolidinedione449.6CCND1, PPARG
13crcs449.6CDKN2A, CCND1
14depsipeptide449.5CDKN2A, CCND1, TERT
15thymidylate449.5CCND1, TERT, CDKN2A
16adriamycin449.5CDKN2A, CCND1, TERT
17nicotine44 28 50 1112.5CCND1, FLG, CDKN2A
18arsenite44 2410.4TERT, CCND1, CDKN2A
19retinoid449.3FLG, PPARG, CCND1
20ns 39844 6110.3CCND1, PTGS2
21butyrate449.3CCND1, CDKN2A, TERT
22paclitaxel44 50 1111.3TERT, CDKN2A, CCND1
23exisulind449.3PTGS2, CCND1, PPARG
24rofecoxib44 50 28 1112.2PPARG, CCND1, PTGS2
25sulindac sulfide449.2CCND1, PPARG, PTGS2
26ciglitazone44 2810.2CCND1, PTGS2, PPARG
27sulindac44 1110.2CCND1, PTGS2, PPARG
28rapamycin449.2PPARG, TERT, CCND1
2915-deoxy-delta-12,14-prostaglandin j2449.2CCND1, PTGS2, PPARG
30celecoxib44 61 28 50 24 1114.2CCND1, PTGS2, PPARG
31resveratrol44 61 24 1112.2CCND1, PTGS2, PPARG
32troglitazone44 28 61 1112.2CCND1, PTGS2, PPARG
33curcumin449.2CCND1, PTGS2, PPARG
34sb 20358044 6110.1PPARG, CCND1, PTGS2
35pd 98,059449.0TERT, CCND1, PTGS2
36sulfasalazine28 44 50 1112.0PPARG, PTGS2
37doxorubicin44 50 1111.0CDKN2A, CCND1, TERT
38testosterone44 61 24 1111.9CDKN2A, CCND1, TERT, PPARG
39nitric oxide44 24 1110.9TERT, PTGS2, FLG, CDKN2A
40egcg448.9TERT, CDKN2A, CCND1, PTGS2
41gf 109203x44 619.9FLG, PTGS2, PPARG, CCND1
42cisplatin44 50 61 1111.9CCND1, TERT, PTGS2, CDKN2A
43ly294002448.8CCND1, PTGS2, TERT, PPARG
44cycloheximide448.7CCND1, CDKN2A, PPARG, PTGS2
45retinoic acid44 249.6CCND1, PPARG, FLG, TERT, CDKN2A
46n acetylcysteine448.4PPARG, TERT, PTGS2, CCND1, CDKN2A
47genistein44 28 61 2 24 1113.4CDKN2A, CCND1, PTGS2, TERT, PPARG
48vegf448.4CDKN2A, PTGS2, TERT, PPARG, CCND1
49serine448.3CCND1, CCNE1, FLG, TERT, CDKN2A
50estrogen447.6PPARG, TERT, PTGS2, CCNE1, CCND1, CDKN2A

GO Terms for genes affiliated with Bowenoid Papulosis

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Cellular components related to Bowenoid Papulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:0003078.8CCNE1, CCND1
2nucleolusGO:0057308.3CDKN2A, CCND1, CCNE1, TERT
3nucleoplasmGO:0056547.6CDKN2A, CCND1, CCNE1, TERT, PPARG

Biological processes related to Bowenoid Papulosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.9CDKN2A, TERT
2organ regenerationGO:0311009.6CCND1, PPARG
3brown fat cell differentiationGO:0508739.5PPARG, PTGS2
4response to estrogenGO:0436279.5CCND1, PPARG
5regulation of blood pressureGO:0082179.3PTGS2, PPARG
6activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.2CDKN2A, PPARG
7cell divisionGO:0513019.1CCND1, CCNE1
8response to drugGO:0424939.0CCND1, PTGS2, PPARG
9G1/S transition of mitotic cell cycleGO:0000828.9CDKN2A, CCND1, CCNE1
10mitotic cell cycleGO:0002788.8CCNE1, CCND1, CDKN2A
11positive regulation of transcription, DNA-templatedGO:0458938.6PPARG, CCNE1, CDKN2A

Molecular functions related to Bowenoid Papulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase regulator activityGO:0165389.0CCND1, CCNE1
2protein kinase bindingGO:0199018.7CDKN2A, CCND1, CCNE1
3enzyme bindingGO:0198998.5CCND1, PTGS2, PPARG

Products for genes affiliated with Bowenoid Papulosis

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Sources for Bowenoid Papulosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet