Aliases & Classifications for Bowen's Disease

MalaCards integrated aliases for Bowen's Disease:

Name: Bowen's Disease 49 69
Bowens Disease 51

Classifications:



External Ids:

UMLS 69 C0006079

Summaries for Bowen's Disease

MalaCards based summary : Bowen's Disease, also known as bowens disease, is related to actinic keratosis and keratosis. An important gene associated with Bowen's Disease is PCNA (Proliferating Cell Nuclear Antigen), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung.

Related Diseases for Bowen's Disease

Diseases related to Bowen's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 actinic keratosis 30.2 KRT17 PCNA
2 keratosis 29.6 KRT10 KRT17
3 squamous cell carcinoma of the larynx 10.3 MKI67 PCNA
4 oral leukoplakia 10.3 MKI67 PCNA
5 benign meningioma 10.2 MKI67 PCNA
6 leukoplakia 10.2 MKI67 PCNA
7 salivary gland adenoid cystic carcinoma 10.2 MKI67 PCNA
8 pachyonychia congenita 2 10.1 KRT16 KRT17
9 tinea corporis 10.1 KRT16 KRT17
10 median rhomboid glossitis 10.1 KRT16 KRT17
11 cervical intraepithelial neoplasia 10.1 KRT17 MKI67
12 palmoplantar keratoderma, epidermolytic 10.1 KRT16 KRT17
13 glossitis 10.1 KRT16 KRT17
14 necrotizing sialometaplasia 10.1 KRT7 MKI67
15 hidradenocarcinoma 10.1 KRT7 MKI67
16 mucinous cystadenocarcinoma 10.1 KRT7 PCNA
17 clear cell basal cell carcinoma 10.1 KRT17 KRT7
18 cervical squamous cell carcinoma 10.1 KRT17 MKI67
19 malignant syringoma 10.1 KRT17 KRT7
20 eccrine sweat gland neoplasm 10.1 KRT17 KRT7
21 ampulla of vater neoplasm 10.0 KRT17 KRT7
22 ampulla of vater adenocarcinoma 10.0 KRT17 KRT7
23 infiltrative basal cell carcinoma 10.0 KRT17 KRT7
24 ovarian mucinous neoplasm 10.0 KRT17 KRT7
25 craniopharyngioma 10.0 KRT7 MKI67
26 basaloid squamous cell carcinoma 10.0 KRT17 KRT7
27 polycystic liver disease 1 10.0 KRT17 KRT7
28 endometrial adenocarcinoma 10.0 KRT7 MKI67
29 monilethrix 10.0 KRT16 KRT17
30 basal cell carcinoma, infundibulocystic 9.9 KRT10 KRT17
31 discoid lupus erythematosus 9.9 KRT10 KRT16
32 palmoplantar keratoderma, nonepidermolytic 9.9 KRT10 KRT16
33 pinguecula 9.9 KRT10 KRT16
34 vulvar intraepithelial neoplasia 9.8 KRT10 KRT7
35 keratosis, seborrheic 9.8 KRT10 KRT17
36 squamous cell carcinoma 9.8
37 porokeratosis 9.8
38 nodular hidradenoma 9.8 KRT10 KRT7
39 bladder adenocarcinoma 9.8 KRT7 MKI67 PCNA
40 inverted papilloma 9.8 KRT7 MKI67 PCNA
41 malignant biphasic mesothelioma 9.8 KRT10 KRT7
42 mucoepidermoid carcinoma 9.8 KRT7 MKI67 PCNA
43 barrett esophagus 9.8 KRT7 MKI67
44 palmoplantar keratosis 9.8 KRT10 KRT16
45 mucinous tubular and spindle renal cell carcinoma 9.8 KRT10 KRT7
46 ichthyosis bullosa of siemens 9.8 KRT10 KRT16
47 epidermolysis bullosa simplex 9.8 KRT10 KRT17
48 intraneural perineurioma 9.8 KRT10 KRT7
49 pericardial mesothelioma 9.8 KRT10 KRT7
50 cholesteatoma 9.7 KRT10 KRT16

Graphical network of the top 20 diseases related to Bowen's Disease:



Diseases related to Bowen's Disease

Symptoms & Phenotypes for Bowen's Disease

Drugs & Therapeutics for Bowen's Disease

Drugs for Bowen's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 2, Phase 3 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 3,Phase 1 106-60-5 137
3 interferons Phase 2, Phase 3
4 Adjuvants, Immunologic Phase 2, Phase 3
5 Interferon Inducers Phase 2, Phase 3
6 Methyl 5-aminolevulinate Phase 3,Phase 1
7 Dermatologic Agents Phase 3,Phase 1
8 Photosensitizing Agents Phase 3,Phase 1
9
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
10
Silicon Approved, Investigational Phase 1 7440-21-3 4082203
11
Prilocaine Approved Phase 1 721-50-6 4906
12
Protoporphyrin IX Experimental Phase 1 553-12-8
13 Silicon phthalocyanine Phase 1
14 EMLA Phase 1
15 Central Nervous System Depressants Phase 1
16 Micronutrients Phase 1
17 Sodium Channel Blockers Phase 1
18 Trace Elements Phase 1
19 Anesthetics Phase 1
20 Anesthetics, Local Phase 1
21 Diuretics, Potassium Sparing Phase 1
22 Peripheral Nervous System Agents Phase 1
23 Anti-Arrhythmia Agents Phase 1
24 Anti-Infective Agents Phase 1
25 Antimalarials Phase 1
26 Antiprotozoal Agents Phase 1
27 Antiparasitic Agents Phase 1
28 Antiviral Agents Phase 1
29
Epinephrine Approved, Vet_approved 51-43-4 5816
30 Racepinephrine Approved 329-65-7
31 Respiratory System Agents
32 Adrenergic Agents
33 Adrenergic Agonists
34 Adrenergic alpha-Agonists
35 Mydriatics
36 Adrenergic beta-Agonists
37 Neurotransmitter Agents
38 Vasoconstrictor Agents
39 Anti-Asthmatic Agents
40 Epinephryl borate
41 Autonomic Agents
42 Bronchodilator Agents

Interventional clinical trials:

(show all 13)

# Name Status NCT ID Phase Drugs
1 Trial of Excision Versus Photodynamic Therapy in the Treatment of Bowen's Disease Terminated NCT00472706 Phase 4
2 Topical Imiquimod for Bowen's Disease of the Head and Neck Unknown status NCT00384124 Phase 2, Phase 3 Imiquimod
3 PDT With Metvix® 160 mg/g Cream in Organ Transplant Recipients With Non-melanoma Skin Cancer Completed NCT00472459 Phase 3
4 Clinical Study Assessment of SR-T100 Topical Gel Against Actinic Keratosis Completed NCT02085395 Phase 2 SR-T100 ® Gel
5 Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Cutaneous Squamous Cell Carcinoma In Situ Completed NCT00329121 Phase 2 PEP005
6 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Bowen's Disease Completed NCT01912976 Phase 1 Er:YAG AFL-PDT;MAL-PDT
7 Long-term Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy for Treatment of Lower Extremity Bowen's Disease Completed NCT03320447 Phase 1 lidocaine-prilocaine 5% cream application;methyl-aminolevulinate application
8 Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II Mycosis Fungoides Completed NCT00103246 Phase 1 silicon phthalocyanine 4
9 Effects of Arsenic on Keratinocytes in a Skin Equivalent Model Unknown status NCT00166946
10 Laser Assisted Drug Delivery in the Treatment of Superficial Non Melanoma Skin Cancer: a Randomized Controlled Trial Completed NCT03012009 MAL;lidocaine hydrochloride 2% with epinephrine
11 Reflectance Confocal Microscopy in Basal Cell Carcinoma Recruiting NCT02623101
12 Photographing the Skin During Photodynamic Therapy Enrolling by invitation NCT03167762
13 Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses, Large/Multiple Superficial Basal Cell Carcinomas (BCCs), or Bowen's Disease No longer available NCT00535080 Metvix (methyl aminolevulinate)

Search NIH Clinical Center for Bowen's Disease

Genetic Tests for Bowen's Disease

Anatomical Context for Bowen's Disease

MalaCards organs/tissues related to Bowen's Disease:

38
Skin, Testes, Lung, Bone

Publications for Bowen's Disease

Articles related to Bowen's Disease:

(show top 50) (show all 139)
# Title Authors Year
1
Clinical experience of ingenol mebutate gel for the treatment of Bowen's disease. ( 29383745 )
2018
2
The role of reflectance confocal microscopy in a case of Bowen's disease difficult to diagnose. ( 29445580 )
2018
3
Cyclin D1 promoter -56 and -54bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen's disease. ( 29103775 )
2018
4
Image Gallery: Bowen's disease of a nail unit presenting with 'woodgrain appearance' - a new dermoscopic finding. ( 29357581 )
2018
5
Bowen's Disease: Long-term Results of Treatment with 5-Fluorouracil Cream, Photodynamic Therapy or Surgical Excision. ( 29135015 )
2018
6
Spindle cell squamous cell carcinoma arising in Bowen's disease: Case report and review of the published work. ( 28370387 )
2017
7
A Case of Bowen's Disease Successfully Treated with Ingenol Mebutate Gel. ( 28761314 )
2017
8
In vivo microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using dynamic optical coherence tomography. ( 28502083 )
2017
9
Giant neglected Bowen's disease lesion treated successfully with topical 5-fluorouracil. ( 28752147 )
2017
10
Trial of hyperthermic treatment for Bowen's disease with disposable chemical pocket warmers: A report of two cases. ( 29239019 )
2017
11
Detection of human papillomavirus type 35 in recurrent Bowen's disease lesions of the fingers. ( 28120774 )
2017
12
Photodynamic therapy with epidermal ablation using fractional carbon-dioxide laser in the treatment of Bowen's disease: A case series. ( 28457851 )
2017
13
A Case of Pagetoid Bowen's Disease. ( 29237947 )
2017
14
Reflectance confocal microscopy of Pigmented Bowen's disease: misleading dendritic cells. ( 27430726 )
2017
15
Genital Bowen's Disease in a Bulgarian Patient: Complete Remission after Surgical Approach. ( 28785358 )
2017
16
Effectiveness of photodynamic therapy in Bowen's disease: a retrospective observational study in 423 lesions. ( 28190258 )
2017
17
Extragenital Human Papillomavirus 16-associated Bowen's Disease. ( 28216736 )
2017
18
Pigmented Bowen's disease associated with high-risk HPV simulating melanoma of the hand. ( 29166507 )
2017
19
Bowen's disease: Two case reports of a giant and dwarf lesions. ( 28643763 )
2017
20
What's new in dermoscopy of Bowen's disease: two new dermoscopic signs and its differential diagnosis. ( 28832993 )
2017
21
Bowen's Disease Associated With Two Human Papilloma Virus Types. ( 29202554 )
2017
22
Phasor-FLIM as a Screening Tool for the Differential Diagnosis of Actinic Keratosis, Bowen's Disease, and Basal Cell Carcinoma. ( 28661125 )
2017
23
Clinical, histological and therapeutic features of Bowen's disease. ( 28523295 )
2017
24
Clinical, histological, and immunohistochemical markers of resistance to Methyl-aminolevulinate Photodynamic therapy in Bowen's disease. ( 28886215 )
2017
25
Human herpesvirus-8 and human cytomegalovirus infections in Bowen's disease: Is there any association? ( 28366922 )
2017
26
Lobulated Bowen's Disease with a Clear Cell Change. ( 28761300 )
2017
27
A case of pigmented Bowen's disease. ( 28225972 )
2017
28
Polydactylous Bowen's Disease in an Immunocompromised Patient: Resolution of All Lesions After Mohs Surgery on a Single Lesion. ( 28930791 )
2017
29
Effectiveness of photodynamic therapy in refractory plaque-stage mycosis fungoides associated with Bowen's disease. ( 28198112 )
2017
30
p16 immunostaining in keratinocytic neoplasia in organ transplant recipients: Bowen's disease shows a characteristic pattern. ( 27717097 )
2017
31
Ingenol Mebutate 150 mg as Physician-Directed Treatment of Bowen's Disease Under Occlusion. ( 27512986 )
2016
32
Human papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen's disease. ( 27342647 )
2016
33
Verrucous Bowen's disease. ( 27595211 )
2016
34
Intraepidermal Merkel cell carcinoma with pagetoid Bowen's disease. ( 27758029 )
2016
35
Anti-retroviral therapy's miracle in the treatment of Bowen's disease in a human immunodeficiency virus-positive patient: A rare case report. ( 27890959 )
2016
36
Porokeratosis simulating Bowen's disease on dermoscopy. ( 28300916 )
2016
37
Topical Photodynamic Therapy for Primary Bowen's Disease and Basal Cell Carcinoma - Optimising Patient Selection. ( 28028807 )
2016
38
Case of pigmented Bowen's disease on the volar aspect of the finger dermoscopically mimicking melanoma in situ. ( 27790749 )
2016
39
Topical 5% imiquimod eliminated human papillomavirus 16-associated Bowen's disease. ( 27451297 )
2016
40
Successful Treatment of Relapsing Bowen's Disease with Ingenol Mebutate: The Use of Dermoscopy to Monitor the Therapeutic Response. ( 27513936 )
2016
41
Extra-Genital Bowen's Disease on Abdomen Co-existing with Vulvar Intraepithelial Neoplasia. ( 27298533 )
2016
42
Bowenoid Actinic Keratosis and Bowen's Disease Treated Successfully with Ingenol Mebutate. ( 27513957 )
2016
43
Bowen's disease of the upper eyelid successfully treated with photodynamic therapy. ( 27519804 )
2016
44
Dermoscopic findings in pigmented Bowen's disease of the lip. ( 27502075 )
2016
45
Pagetoid Bowen's disease of vulva: Excellent response to imiquimod. ( 27506507 )
2016
46
Pigmented Bowen's disease presenting with a "starburst" pattern. ( 27867748 )
2016
47
Pretreatment with topical glucocorticosteroids to enhance the anti-tumour efficacy of imiquimod: long-term follow-up in Bowen's disease. ( 27542777 )
2016
48
Onychocytic matricoma as an underrecognized benign mimicker of subungual malignant melanoma and Bowen's disease. ( 27650048 )
2016
49
Giant Bowen's disease histologically showing Borst-Jadassohn phenomenon and complicated with squamous cell carcinoma development. ( 26373350 )
2016
50
A Case of Recurrent Eccrine Porocarcinoma with Regional Lymph Nodal Metastasis, Arising on a Bowen's Disease Patch. ( 25972690 )
2015

Variations for Bowen's Disease

Expression for Bowen's Disease

Search GEO for disease gene expression data for Bowen's Disease.

Pathways for Bowen's Disease

Pathways related to Bowen's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 KRT10 KRT16 KRT17 KRT7
2 11.82 KRT10 KRT17 KRT7
3
Show member pathways
11.38 KRT10 KRT16 KRT17 KRT7
4
Show member pathways
11.17 KRT16 KRT17 KRT7
5 11.13 MKI67 PCNA

GO Terms for Bowen's Disease

Cellular components related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 KRT10 KRT16 KRT17 KRT7 PCNA
2 intermediate filament GO:0005882 8.92 KRT10 KRT16 KRT17 KRT7

Biological processes related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.33 KRT16 MKI67 PCNA
2 epidermis development GO:0008544 9.32 KRT16 KRT17
3 keratinocyte differentiation GO:0030216 9.26 KRT10 KRT16
4 keratinization GO:0031424 9.26 KRT10 KRT16 KRT17 KRT7
5 cornification GO:0070268 8.92 KRT10 KRT16 KRT17 KRT7

Molecular functions related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.96 KRT16 KRT17
2 structural molecule activity GO:0005198 8.92 KRT10 KRT16 KRT17 KRT7

Sources for Bowen's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....