Aliases & Classifications for Bowen's Disease

MalaCards integrated aliases for Bowen's Disease:

Name: Bowen's Disease 50 69
Bowens Disease 52

Classifications:



Summaries for Bowen's Disease

MalaCards based summary : Bowen's Disease, also known as bowens disease, is related to gastric adenocarcinoma and orbital lymphoma. An important gene associated with Bowen's Disease is PCNA (Proliferating Cell Nuclear Antigen), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung.

Related Diseases for Bowen's Disease

Diseases related to Bowen's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
id Related Disease Score Top Affiliating Genes
1 gastric adenocarcinoma 10.4 MKI67 PCNA
2 orbital lymphoma 10.4 MKI67 PCNA
3 pediatric meningioma 10.3 MKI67 PCNA
4 childhood oligodendroglioma 10.3 MKI67 PCNA
5 levy-yeboa syndrome 10.3 MKI67 PCNA
6 laryngeal adenoid cystic carcinoma 10.2 MKI67 PCNA
7 lung sarcoma 10.2 FLG KRT16
8 uremic neuropathy 10.1 FLG KRT10
9 chondrodysplasia punctata, x-linked recessive 10.0 FLG KRT10
10 bullous keratopathy 10.0 KRT10 KRT16
11 nominal aphasia 10.0 MKI67 PCNA
12 keratosis 10.0
13 epidermolysis bullosa simplex, dowling-meara type 10.0 KRT10 KRT16
14 actinic keratosis 10.0
15 carotid artery disease 9.9 KRT10 KRT16
16 steatocystoma multiplex 9.9 KRT16 KRT17
17 dicrocoeliasis 9.9 KRT16 KRT17
18 basal cell carcinoma 4 9.9 KRT16 KRT17
19 small intestine leiomyoma 9.9 FLG KRT17
20 telangiectasia, hereditary hemorrhagic, type 2 9.9 KRT10 KRT16
21 keratosis palmoplantaris striata iii 9.9 KRT16 KRT17
22 bacteriuria 9.9 KRT16 KRT17
23 cerebellar disease 9.9 FLG KRT16
24 papilledema 9.9 KRT16 KRT17
25 charcot-marie-tooth disease type 2a 9.9 KRT17 MKI67
26 pigmented basal cell carcinoma 9.8 KRT10 KRT17
27 acantholytic acanthoma 9.8 KRT10 KRT17
28 fasciolopsiasis 9.8 KRT17 PCNA
29 squamous cell carcinoma 9.8
30 porokeratosis 9.8
31 infantile-onset axonal motor and sensory neuropathy-optic atrophy-neurodegenerative syndrome 9.7 KRT10 KRT16 MKI67
32 clove syndrome, somatic 9.7 KRT10 KRT17
33 childhood type dermatomyositis 9.7 KRT17 MKI67
34 colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas 9.7 KRT10 KRT17
35 steroid inherited metabolic disorder 9.7 FLG KRT10
36 autonomic nervous system neoplasm 9.7 FLG KRT10 PCNA
37 ectodermal dysplasia 4, hair/nail type 9.7 KRT16 KRT17
38 aids wasting syndrome 9.6 FLG KRT10 KRT16
39 retinitis pigmentosa 30 9.6 FLG KRT10 KRT16
40 neuropathy 9.6 FLG KRT10 KRT16
41 richter's syndrome 9.6 FLG KRT10
42 central sleep apnea 9.6 FLG KRT10 KRT16
43 epidermodysplasia verruciformis 9.6
44 paronychia 9.6
45 eccrine porocarcinoma 9.6
46 linear porokeratosis 9.6
47 small non-cleaved cell lymphoma 9.6 FLG KRT10 KRT16
48 catecholaminergic polymorphic ventricular tachycardia 5 9.4 FLG KRT10
49 sclerosteosis 1 9.3 KRT10 KRT16 KRT17
50 hypochromic microcytic anemia 9.3 KRT10 KRT16 KRT17

Graphical network of the top 20 diseases related to Bowen's Disease:



Diseases related to Bowen's Disease

Symptoms & Phenotypes for Bowen's Disease

Drugs & Therapeutics for Bowen's Disease

Drugs for Bowen's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 2, Phase 3 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 3,Phase 1 106-60-5 137
3 Adjuvants, Immunologic Phase 2, Phase 3
4 Interferon Inducers Phase 2, Phase 3
5 interferons Phase 2, Phase 3
6 Dermatologic Agents Phase 3,Phase 1
7 Methyl 5-aminolevulinate Phase 3,Phase 1
8 Photosensitizing Agents Phase 3,Phase 1
9
Leuprolide Approved, Investigational Phase 2 53714-56-0 3911 657181
10 Antineoplastic Agents, Hormonal Phase 2
11 Fertility Agents Phase 2
12 Hormones Phase 2
13
Ethanol Approved Phase 1 64-17-5 702
14
Oxytocin Approved, Vet_approved Phase 1 50-56-6 439302 53477758
15
Silicon Investigational Phase 1 7440-21-3 4082203
16 Anti-Infective Agents Phase 1
17 Antimalarials Phase 1
18 Antiparasitic Agents Phase 1
19 Antiprotozoal Agents Phase 1
20 Antiviral Agents Phase 1
21 Micronutrients Phase 1
22 Silicon phthalocyanine Phase 1
23 Trace Elements Phase 1
24 Oxytocics Phase 1
25
Bismuth Subsalicylate Approved, Vet_approved 14882-18-9 53629521
26
Loperamide Approved 53179-11-6 3955
27
Epinephrine Approved, Vet_approved 51-43-4 5816
28
Lidocaine Approved, Vet_approved 137-58-6 3676
29 Racepinephrine Approved
30 Antacids
31 Anti-Bacterial Agents
32 Antidiarrheals
33 Anti-Ulcer Agents
34
Bismuth 7440-69-9 16682734 105143
35 Gastrointestinal Agents
36 Adrenergic Agents
37 Adrenergic Agonists
38 Adrenergic alpha-Agonists
39 Adrenergic beta-Agonists
40 Anesthetics
41 Anesthetics, Local
42 Anti-Arrhythmia Agents
43 Anti-Asthmatic Agents
44 Autonomic Agents
45 Bronchodilator Agents
46 Central Nervous System Depressants
47 Diuretics, Potassium Sparing
48 Epinephryl borate
49 Mydriatics
50 Neurotransmitter Agents

Interventional clinical trials:

(show all 19)

id Name Status NCT ID Phase Drugs
1 Evaluation of a Handwashing Promotion Program in Chinese Elementary Schools Completed NCT00140335 Phase 4
2 Trial of Excision Versus Photodynamic Therapy in the Treatment of Bowen's Disease Terminated NCT00472706 Phase 4
3 Topical Imiquimod for Bowen's Disease of the Head and Neck Unknown status NCT00384124 Phase 2, Phase 3 Imiquimod
4 PDT With Metvix® 160 mg/g Cream in Organ Transplant Recipients With Non-melanoma Skin Cancer Completed NCT00472459 Phase 3
5 Clinical Study Assessment of SR-T100 Topical Gel Against Actinic Keratosis Completed NCT02085395 Phase 2 SR-T100 ® Gel
6 Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Cutaneous Squamous Cell Carcinoma In Situ Completed NCT00329121 Phase 2 PEP005
7 Antigonadotropin-Leuprolide in Alzheimer's Disease Drug INvestigation (ALADDIN) VP 104 Study Completed NCT00076440 Phase 2 Leuprolide acetate
8 ALADDIN Study: Antigonadotropin-Leuprolide in Alzheimer's Disease Drug INvestigation Completed NCT00063310 Phase 2 Leuprolide acetate
9 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Bowen's Disease Completed NCT01912976 Phase 1 Er:YAG AFL-PDT;MAL-PDT
10 Long-term Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy for Treatment of Lower Extremity Bowen's Disease Completed NCT03320447 Phase 1 lidocaine-prilocaine 5% cream application;methyl-aminolevulinate application
11 Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II Mycosis Fungoides Completed NCT00103246 Phase 1 silicon phthalocyanine 4
12 Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress Completed NCT02058251 Phase 1 Oxytocin;Placebo
13 Effects of Arsenic on Keratinocytes in a Skin Equivalent Model Unknown status NCT00166946
14 Evaluation of a Handwashing Promotion Program in Three Countries Completed NCT01043809
15 Impact of Bismuth Subsalicylate on Antimicrobial Use Among Adult Diarrhea Outpatients--Pakistan Completed NCT02047162 Bismuth subsalicylate
16 Laser Assisted Drug Delivery in the Treatment of Superficial Non Melanoma Skin Cancer: a Randomized Controlled Trial Recruiting NCT03012009 MAL;lidocaine hydrochloride 2% with epinephrine
17 Reflectance Confocal Microscopy in Basal Cell Carcinoma Recruiting NCT02623101
18 Photographing the Skin During Photodynamic Therapy Enrolling by invitation NCT03167762
19 Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses, Large/Multiple Superficial Basal Cell Carcinomas (BCCs), or Bowen's Disease No longer available NCT00535080 Metvix (methyl aminolevulinate)

Search NIH Clinical Center for Bowen's Disease

Genetic Tests for Bowen's Disease

Anatomical Context for Bowen's Disease

MalaCards organs/tissues related to Bowen's Disease:

39
Skin, Testes, Lung, Bone

Publications for Bowen's Disease

Articles related to Bowen's Disease:

(show top 50) (show all 130)
id Title Authors Year
1
What's new in dermoscopy of Bowen's disease: two new dermoscopic signs and its differential diagnosis. ( 28832993 )
2017
2
Clinical, histological and therapeutic features of Bowen's disease. ( 28523295 )
2017
3
Effectiveness of photodynamic therapy in refractory plaque-stage mycosis fungoides associated with Bowen's disease. ( 28198112 )
2017
4
Reflectance confocal microscopy of Pigmented Bowen's disease: misleading dendritic cells. ( 27430726 )
2017
5
Human herpesvirus-8 and human cytomegalovirus infections in Bowen's disease: Is there any association? ( 28366922 )
2017
6
A Case of Bowen's Disease Successfully Treated with Ingenol Mebutate Gel. ( 28761314 )
2017
7
Phasor-FLIM as a Screening Tool for the Differential Diagnosis of Actinic Keratosis, Bowen's Disease, and Basal Cell Carcinoma. ( 28661125 )
2017
8
In vivo microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using dynamic optical coherence tomography. ( 28502083 )
2017
9
Effectiveness of photodynamic therapy in Bowen's disease: a retrospective observational study in 423 lesions. ( 28190258 )
2017
10
Bowen's disease: Two case reports of a giant and dwarf lesions. ( 28643763 )
2017
11
Spindle cell squamous cell carcinoma arising in Bowen's disease: Case report and review of the published work. ( 28370387 )
2017
12
Extragenital Human Papillomavirus 16-associated Bowen's Disease. ( 28216736 )
2017
13
p16 immunostaining in keratinocytic neoplasia in organ transplant recipients: Bowen's disease shows a characteristic pattern. ( 27717097 )
2017
14
Clinical, histological, and immunohistochemical markers of resistance to Methyl-aminolevulinate Photodynamic therapy in Bowen's disease. ( 28886215 )
2017
15
A case of pigmented Bowen's disease. ( 28225972 )
2017
16
Polydactylous Bowen's Disease in an Immunocompromised Patient: Resolution of All Lesions After Mohs Surgery on a Single Lesion. ( 28930791 )
2017
17
Giant neglected Bowen's disease lesion treated successfully with topical 5-fluorouracil. ( 28752147 )
2017
18
Lobulated Bowen's Disease with a Clear Cell Change. ( 28761300 )
2017
19
Genital Bowen's Disease in a Bulgarian Patient: Complete Remission after Surgical Approach. ( 28785358 )
2017
20
Detection of human papillomavirus type 35 in recurrent Bowen's disease lesions of the fingers. ( 28120774 )
2017
21
Photodynamic therapy with epidermal ablation using fractional carbon-dioxide laser in the treatment of Bowen's disease: A case series. ( 28457851 )
2017
22
Bowen's disease of the upper eyelid successfully treated with photodynamic therapy. ( 27519804 )
2016
23
Anti-retroviral therapy's miracle in the treatment of Bowen's disease in a human immunodeficiency virus-positive patient: A rare case report. ( 27890959 )
2016
24
Pagetoid Bowen's disease of vulva: Excellent response to imiquimod. ( 27506507 )
2016
25
Onychocytic matricoma as an underrecognized benign mimicker of subungual malignant melanoma and Bowen's disease. ( 27650048 )
2016
26
Dermoscopic findings in pigmented Bowen's disease of the lip. ( 27502075 )
2016
27
Bowenoid Actinic Keratosis and Bowen's Disease Treated Successfully with Ingenol Mebutate. ( 27513957 )
2016
28
Ingenol Mebutate 150 mg as Physician-Directed Treatment of Bowen's Disease Under Occlusion. ( 27512986 )
2016
29
Giant Bowen's disease histologically showing Borst-Jadassohn phenomenon and complicated with squamous cell carcinoma development. ( 26373350 )
2016
30
Successful Treatment of Relapsing Bowen's Disease with Ingenol Mebutate: The Use of Dermoscopy to Monitor the Therapeutic Response. ( 27513936 )
2016
31
Intraepidermal Merkel cell carcinoma with pagetoid Bowen's disease. ( 27758029 )
2016
32
Porokeratosis simulating Bowen's disease on dermoscopy. ( 28300916 )
2016
33
Topical Photodynamic Therapy for Primary Bowen's Disease and Basal Cell Carcinoma - Optimising Patient Selection. ( 28028807 )
2016
34
Human papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen's disease. ( 27342647 )
2016
35
Verrucous Bowen's disease. ( 27595211 )
2016
36
Pigmented Bowen's disease presenting with a "starburst" pattern. ( 27867748 )
2016
37
Topical 5% imiquimod eliminated human papillomavirus 16-associated Bowen's disease. ( 27451297 )
2016
38
Pretreatment with topical glucocorticosteroids to enhance the anti-tumour efficacy of imiquimod: long-term follow-up in Bowen's disease. ( 27542777 )
2016
39
Case of pigmented Bowen's disease on the volar aspect of the finger dermoscopically mimicking melanoma in situ. ( 27790749 )
2016
40
Extra-Genital Bowen's Disease on Abdomen Co-existing with Vulvar Intraepithelial Neoplasia. ( 27298533 )
2016
41
Merkel Cell Carcinoma Concomitant with Invasive Bowen's Disease: Immunohistochemical Investigation of Tumor-Infiltrating Leukocytes. ( 25759650 )
2015
42
A Case of Recurrent Eccrine Porocarcinoma with Regional Lymph Nodal Metastasis, Arising on a Bowen's Disease Patch. ( 25972690 )
2015
43
Multiple clear cell acanthoma associated with multiple Bowen's disease. ( 24898560 )
2014
44
Co-existence of porokeratosis variants concurrent with Bowen's disease: two rare cases report. ( 25123017 )
2014
45
Case of oculocutaneous albinism complicated with squamous cell carcinoma, Bowen's disease and actinic keratosis. ( 25182297 )
2014
46
Immunohistochemical staining for p16 is a useful adjunctive test in the diagnosis of Bowen's disease. ( 23635817 )
2013
47
European guidelines for topical photodynamic therapy part 1: treatment delivery and current indications - actinic keratoses, Bowen's disease, basal cell carcinoma. ( 23181594 )
2013
48
Merkel cell carcinoma concurrent with Bowen's disease: two cases, one with an unusual immunophenotype. ( 23672777 )
2013
49
British Association of Dermatologists' guidelines for the management of squamous cell carcinoma in situ (Bowen's disease) 2014. ( 24313974 )
2013
50
Bowenoid papulosis and invasive Bowen's disease: a multidisciplinary approach. ( 22717936 )
2013

Variations for Bowen's Disease

Expression for Bowen's Disease

Search GEO for disease gene expression data for Bowen's Disease.

Pathways for Bowen's Disease

Pathways related to Bowen's Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 FLG KRT10 KRT16 KRT17
2
Show member pathways
11.38 FLG KRT10 KRT16 KRT17
3
Show member pathways
11.29 KRT16 KRT17
4 10.82 MKI67 PCNA

GO Terms for Bowen's Disease

Cellular components related to Bowen's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.96 FLG KRT10
2 intermediate filament GO:0005882 8.92 FLG KRT10 KRT16 KRT17

Biological processes related to Bowen's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.58 KRT16 MKI67 PCNA
2 keratinization GO:0031424 9.5 KRT10 KRT16 KRT17
3 epidermis development GO:0008544 9.43 KRT16 KRT17
4 peptide cross-linking GO:0018149 9.37 FLG KRT10
5 establishment of skin barrier GO:0061436 9.26 FLG KRT16
6 skin epidermis development GO:0098773 9.16 FLG KRT10
7 keratinocyte differentiation GO:0030216 9.13 FLG KRT10 KRT16
8 cornification GO:0070268 8.92 FLG KRT10 KRT16 KRT17

Molecular functions related to Bowen's Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.16 KRT16 KRT17
2 structural constituent of epidermis GO:0030280 8.96 FLG KRT10
3 structural molecule activity GO:0005198 8.8 FLG KRT16 KRT17

Sources for Bowen's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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