MCID: BRC010
MIFTS: 34

Brachial Plexus Lesion

Categories: Neuronal diseases

Aliases & Classifications for Brachial Plexus Lesion

MalaCards integrated aliases for Brachial Plexus Lesion:

Name: Brachial Plexus Lesion 12 14 69
Brachial Plexus Injuries 50 40
Brachial Plexus Lesions Nos 12
Brachial Plexus Lesions 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8443
ICD9CM 34 353.0
SNOMED-CT 64 193109004 3548001
ICD10 32 S14.3
UMLS 69 C0006091

Summaries for Brachial Plexus Lesion

NINDS : 50 The brachial plexus is a network of nerves that conducts signals from the spine to the shoulder, arm, and hand. Brachial plexus injuries are caused by damage to those nerves. Symptoms may include a limp or paralyzed arm; lack of muscle control in the arm, hand, or wrist; and a lack of feeling or sensation in the arm or hand.   Brachial plexus injuries can occur as a result of shoulder trauma, tumors, or inflammation.  There is a rare syndrome called Parsonage-Turner Syndrome, or brachial plexitis, which causes inflammation of the brachial plexus without any obvious shoulder injury.  This syndrome can begin with severe shoulder or arm pain followed by weakness and numbness. In infants, brachial plexus injuries may happen during birth if the baby’s shoulder is stretched during passage in the birth canal (see Brachial Plexus Birth Injuries).    The severity of a brachial plexus injury is determined by the type of damage done to the nerves.  The most severe type,avulsion, is caused when the nerve root is severed or cut from the spinal cord.  There is also an incomplete form of avulsion in which part of the nerve is damaged and which leaves some opportunity for the nerve to slowly recover function.   Neuropraxia, or stretch injury, is the mildest type of injury   Neuropraxia damages the protective covering of the nerve, which causes problems with nerve signal conduction, but does not always damage the nerve underneath.

MalaCards based summary : Brachial Plexus Lesion, also known as brachial plexus injuries, is related to non-recovering obstetric brachial plexus lesion and klumpke paralysis. An important gene associated with Brachial Plexus Lesion is SERPINI2 (Serpin Family I Member 2), and among its related pathways/superpathways are Guidance Cues and Growth Cone Motility and G-protein signaling TC21 regulation pathway. Affiliated tissues include spinal cord and skin, and related phenotypes are growth/size/body region and nervous system

Disease Ontology : 12 A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus.

MedlinePlus : 40 The brachial plexus is a network of nerves that sends signals from the spine to the shoulder, arm, and hand. Damage to the brachial plexus can cause symptoms such as A limp or paralyzed arm Lack of muscle control in the arm, hand, or wrist Lack of feeling or sensation in the arm or hand Brachial plexus injuries can happen because of shoulder trauma, tumors, or inflammation. Sometimes they happen during childbirth when a baby's shoulders become stuck during delivery and the nerves stretch or tear. Some brachial plexus injuries may heal without treatment. Many children who are injured during birth improve or recover by 3 to 4 months of age. Treatment includes physical therapy and, in some cases, surgery. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 72 A brachial plexus injury (BPI), also known as brachial plexus lesion, is an injury to the brachial... more...

Related Diseases for Brachial Plexus Lesion

Diseases related to Brachial Plexus Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 non-recovering obstetric brachial plexus lesion 12.3
2 klumpke paralysis 11.5
3 erb-duchenne and dejerine-klumpke palsies 11.5
4 erb's palsy 11.5
5 ulnar neuropathy 10.4 CAMP SERPINI2
6 brachial plexus neuropathy 10.4 SERPINI2 SRPX2 XIRP1
7 epicondylitis 10.3 SERPINI2 TAC1
8 prurigo nodularis 10.3 SEMA3A TAC1
9 myofascial pain syndrome 10.2 CAMP TAC1
10 tolosa-hunt syndrome 10.1 NF1 NLRP3
11 plexopathy 10.1 CAMP CRLF1 NLRP3
12 segmental dystonia 10.1 BDNF CAMP
13 cerebral artery occlusion 10.1 BDNF GDNF
14 obstructive hydrocephalus 10.1 CRLF1 NF1
15 burn scar 10.0 CALCA TAC1
16 benign epilepsy with centrotemporal spikes 10.0 BDNF CAMP SRPX2
17 neuroma 10.0 CALCA GDNF SEMA3F
18 duodenal somatostatinoma 10.0 CALCA NF1
19 giant cell reparative granuloma 9.9 CALCA NF1
20 anismus 9.9 CAMP OXT TAC1
21 vasomotor rhinitis 9.9 CALCA TAC1
22 trigeminal nerve disease 9.9 CRLF1 TAC1
23 multiple endocrine neoplasia, type iia 9.8 CALCA GDNF NF1
24 multiple endocrine neoplasia 9.8 CALCA GDNF NF1
25 angiomatous meningioma 9.8 NRP1 SEMA3A WDFY2
26 episodic pain syndrome, familial, 1 9.8
27 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.8
28 aneurysm 9.8
29 urticaria pigmentosa 9.7 CALCA TAC1
30 specific developmental disorder 9.7 BDNF OXT TAC1
31 multiple personality disorder 9.6 OXT WDFY2

Graphical network of the top 20 diseases related to Brachial Plexus Lesion:



Diseases related to Brachial Plexus Lesion

Symptoms & Phenotypes for Brachial Plexus Lesion

MGI Mouse Phenotypes related to Brachial Plexus Lesion:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.7 BDNF GAL GDNF NF1 NLRP3 NRP1
2 nervous system MP:0003631 9.32 BDNF CRLF1 GAL GDNF NF1 NLRP3

Drugs & Therapeutics for Brachial Plexus Lesion

Search Clinical Trials , NIH Clinical Center for Brachial Plexus Lesion

Genetic Tests for Brachial Plexus Lesion

Anatomical Context for Brachial Plexus Lesion

MalaCards organs/tissues related to Brachial Plexus Lesion:

38
Spinal Cord, Skin

Publications for Brachial Plexus Lesion

Articles related to Brachial Plexus Lesion:

(show all 28)
# Title Authors Year
1
Glenoid morphology in obstetrical brachial plexus lesion: a three-dimensional computed tomography study. ( 28412107 )
2017
2
Unusual brachial plexus lesion: Hematoma masquerading as a peripheral nerve sheath tumor. ( 26904368 )
2016
3
Long-term outcome of accessory nerve to suprascapular nerve transfer in obstetric brachial plexus lesion: functional, morphological, and electrophysiological results. ( 26111514 )
2015
4
Ultrasound-guided pulse-dose radiofrequency: treatment of neuropathic pain after brachial plexus lesion and arm revascularization. ( 25525439 )
2014
5
Explaining daily functioning in young adults with obstetric brachial plexus lesion. ( 25332088 )
2014
6
The effect of perinatal brachial plexus lesion on upper limb development. ( 24694070 )
2014
7
Hand sensation in adults with conservatively treated obstetric brachial plexus lesion. ( 23163967 )
2013
8
A cross-sectional study of hand sensation in adults with conservatively treated obstetric brachial plexus lesion. ( 23121196 )
2013
9
Recovery of brachial plexus lesions resulting from heavy backpack use: a follow-up case series. ( 21429232 )
2011
10
Extremity shortness in obstetric brachial plexus lesion and its relationship to root avulsion. ( 18174555 )
2007
11
Development of a set of activities to evaluate the arm and hand function in children with obstetric brachial plexus lesion. ( 17264110 )
2007
12
Detection of root avulsion in the dominant C7 obstetric brachial plexus lesion: experience with three-dimensional constructive interference in steady-state magnetic resonance imaging and electrophysiology. ( 16284563 )
2005
13
Brachial plexus lesion following an anterior dislocation of the shoulder. ( 15167179 )
2004
14
Measuring secondary deformities of the shoulder in children with obstetric brachial plexus lesion: reliability of three methods. ( 12703037 )
2003
15
Retroversion of the humeral head in children with an obstetric brachial plexus lesion. ( 12043783 )
2002
16
Secondary operation for elbow flexion reconstruction after brachial plexus lesion. ( 28246804 )
1997
17
Rehabilitation of patient with brachial plexus lesion and break in axillary artery. Case study. ( 8994018 )
1996
18
Repair of ruptured spinal nerve roots in a brachial plexus lesion. Case report. ( 7897534 )
1995
19
[Brachial plexus lesions and rhabdomyolysis following heroin abuse. Indications for an immunological cause]. ( 7828462 )
1995
20
A new type of brachial plexus lesion to be added to the classical types. ( 7718039 )
1994
21
A fourth type of brachial plexus lesion: the intermediate (C7) palsy. ( 1791357 )
1991
22
Idiopathic brachial plexus lesion with conduction block of the ulnar nerve. ( 2465129 )
1989
23
Prosthetic rehabilitation in unilateral high above-elbow amputation and brachial plexus lesion: case report. ( 3964062 )
1986
24
A spontaneous relocation of a dislocated Neer prosthesis. Occurs with recovery of brachial plexus lesion. ( 3453468 )
1986
25
Brachial plexus lesion complication sternotomy. ( 7119825 )
1982
26
Successful repair of a complete brachial plexus lesion. ( 5522062 )
1970
27
Brachial plexus lesion. ( 5612894 )
1967
28
Axillary aneurysm associated with a brachial plexus lesion. ( 5911425 )
1966

Variations for Brachial Plexus Lesion

Expression for Brachial Plexus Lesion

Search GEO for disease gene expression data for Brachial Plexus Lesion.

Pathways for Brachial Plexus Lesion

Pathways related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.2 BDNF NRP1 SEMA3A
2
Show member pathways
10.53 NF1 NRP1 SEMA3A

GO Terms for Brachial Plexus Lesion

Cellular components related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CALCA CAMP CRLF1 GAL NRP1 OXT
2 axon GO:0030424 9.55 CALCA NF1 NRP1 SEMA3A TAC1
3 extracellular region GO:0005576 9.47 BDNF CALCA CAMP CRLF1 GAL GDNF

Biological processes related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.97 BDNF CALCA NRP1 TAC1
2 axon guidance GO:0007411 9.96 BDNF GDNF NRP1 SEMA3A SEMA3F
3 heart development GO:0007507 9.94 NF1 NRP1 OXT XIRP1
4 negative regulation of neuron apoptotic process GO:0043524 9.9 BDNF CRLF1 GDNF NRP1
5 neuropeptide signaling pathway GO:0007218 9.84 CALCA GAL TAC1
6 positive regulation of synapse assembly GO:0051965 9.81 BDNF OXT SRPX2
7 regulation of heart rate GO:0002027 9.77 CALCA OXT SEMA3A
8 positive regulation of ossification GO:0045778 9.72 CALCA OXT TAC1
9 nerve development GO:0021675 9.71 NRP1 SEMA3A SEMA3F
10 facial nerve structural organization GO:0021612 9.7 NRP1 SEMA3A SEMA3F
11 semaphorin-plexin signaling pathway GO:0071526 9.69 NRP1 SEMA3A
12 artery morphogenesis GO:0048844 9.69 NF1 NRP1
13 negative regulation of axon extension involved in axon guidance GO:0048843 9.69 NRP1 SEMA3A SEMA3F
14 peripheral nervous system development GO:0007422 9.68 GDNF NF1
15 negative regulation of osteoclast differentiation GO:0045671 9.68 CALCA NF1
16 motor neuron axon guidance GO:0008045 9.68 NRP1 SEMA3A
17 response to pain GO:0048265 9.68 CALCA TAC1
18 negative regulation of axon extension GO:0030517 9.67 NRP1 SEMA3A
19 axonal fasciculation GO:0007413 9.67 NRP1 SEMA3A
20 sympathetic ganglion development GO:0061549 9.67 NRP1 SEMA3A SEMA3F
21 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.65 NRP1 SRPX2
22 positive regulation of renal sodium excretion GO:0035815 9.65 OXT TAC1
23 positive regulation of adenylate cyclase activity GO:0045762 9.65 CALCA NF1
24 axon extension involved in axon guidance GO:0048846 9.65 NRP1 SEMA3A SEMA3F
25 regulation of axon extension involved in axon guidance GO:0048841 9.63 NRP1 SEMA3A
26 cellular response to peptidoglycan GO:0071224 9.63 CAMP NLRP3
27 branchiomotor neuron axon guidance GO:0021785 9.63 NRP1 SEMA3A SEMA3F
28 dichotomous subdivision of terminal units involved in salivary gland branching GO:0060666 9.62 NRP1 SEMA3A
29 dendrite arborization GO:0140059 9.62 NRP1 SEMA3A
30 axonogenesis involved in innervation GO:0060385 9.61 NRP1 SEMA3A
31 trigeminal ganglion development GO:0061551 9.61 NRP1 SEMA3A
32 trigeminal nerve structural organization GO:0021637 9.61 NRP1 SEMA3A SEMA3F
33 facioacoustic ganglion development GO:1903375 9.58 NRP1 SEMA3A
34 gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828 9.58 NRP1 SEMA3A
35 semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 9.58 NRP1 SEMA3A SEMA3F
36 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.54 NRP1 SEMA3A SEMA3F
37 sympathetic neuron projection extension GO:0097490 9.5 NRP1 SEMA3A SEMA3F
38 sympathetic neuron projection guidance GO:0097491 9.43 NRP1 SEMA3A SEMA3F
39 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 9.33 NRP1 SEMA3A SEMA3F
40 ventral trunk neural crest cell migration GO:0036486 9.13 NRP1 SEMA3A SEMA3F
41 sympathetic nervous system development GO:0048485 8.92 GDNF NF1 NRP1 SEMA3A
42 nervous system development GO:0007399 10.06 BDNF GAL GDNF NRP1 SEMA3A
43 regulation of receptor activity GO:0010469 10.04 BDNF CALCA CRLF1 GAL GDNF OXT

Molecular functions related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 9.26 CRLF1 NRP1
2 neuropilin binding GO:0038191 9.16 SEMA3A SEMA3F
3 hormone activity GO:0005179 9.13 CALCA GAL OXT
4 chemorepellent activity GO:0045499 8.62 SEMA3A SEMA3F

Sources for Brachial Plexus Lesion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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