MCID: BRC010
MIFTS: 36

Brachial Plexus Lesion malady

Neuronal diseases category

Aliases & Classifications for Brachial Plexus Lesion

About this section

Aliases & Descriptions for Brachial Plexus Lesion:

Name: Brachial Plexus Lesion 10 12 65
Brachial Plexus Injuries 46 35
 
Brachial Plexus Lesions Nos 10
Brachial Plexus Lesions 10


Classifications:



External Ids:

Disease Ontology10 DOID:8443
ICD9CM29 353.0
SNOMED-CT59 3548001, 193109004
ICD1027 S14.3

Summaries for Brachial Plexus Lesion

About this section
MedlinePlus:35 The brachial plexus is a network of nerves that conducts signals from the spine to the shoulder, arm, and hand. brachial plexus injuries are caused by damage to those nerves. symptoms may include a limp or paralyzed arm lack of muscle control in the arm, hand, or wrist lack of feeling or sensation in the arm or hand brachial plexus injuries can occur as a result of shoulder trauma, tumors, or inflammation. sometimes they happen during childbirth when a baby's shoulders become stuck during delivery and the nerves stretch or tear. some brachial plexus injuries may heal without treatment. many children who are injured during birth improve or recover by 3 to 4 months of age. treatment includes physical therapy and, in some cases, surgery. nih: national institute of neurological disorders and stroke

MalaCards based summary: Brachial Plexus Lesion, also known as brachial plexus injuries, is related to brachial plexus birth injuries and klumpke paralysis. An important gene associated with Brachial Plexus Lesion is XIRP1 (Xin Actin Binding Repeat Containing 1), and among its related pathways are Guidance Cues and Growth Cone Motility and Axon guidance. Affiliated tissues include skin and spinal cord, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Disease Ontology:10 A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus.

NINDS:46 The brachial plexus is a network of nerves that conducts signals from the spine to the shoulder, arm, and hand. Brachial plexus injuries are caused by damage to those nerves. Symptoms may include a limp or paralyzed arm; lack of muscle control in the arm, hand, or wrist; and a lack of feeling or sensation in the arm or hand.

Wikipedia:68 The brachial plexus is a network of nerves that conducts signals from the spinal cord, which is housed... more...

Related Diseases for Brachial Plexus Lesion

About this section

Diseases related to Brachial Plexus Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1brachial plexus birth injuries10.6
2klumpke paralysis10.6
3erb-duchenne and dejerine-klumpke palsies10.6
4non-recovering obstetric brachial plexus lesion10.5
5horner's syndrome10.4
6siderosis10.4
7fetal macrosomia10.4
8superficial siderosis10.4
9periapical granuloma10.3PMP22, SERPINI2
10dysautonomia, familial10.2
11brachial plexus neuritis10.2
12sensory peripheral neuropathy10.2
13cannabis abuse10.2
14causalgia10.2
15pain disorder10.2
16femoral neuropathy10.2
17brachial plexus neuropathy10.2
18complex regional pain syndrome10.2
19endometriosis10.2
20neuritis10.2
21neuropathy10.2
22peripheral neuropathy10.2
23sleep disorder10.2
24cerebrospinal fluid leak10.2
25superficial siderosis of the central nervous system10.2
26central cord syndrome10.2
27chronic pain10.2
28erb's palsy10.2
29head injury10.2
30headache10.2
31aneurysm10.2
32chronic progressive external ophthalmoplegia10.2NF1, PMP22
33vulvar inverted follicular keratosis10.2CRLF1, NF1
34mood disorder10.2PMP22, SERPINI2
35nasal cavity carcinoma in situ10.2CALCA, NF1
36pruritic urticarial papules plaques of pregnancy10.1SEMA3A, TAC1
37uterine corpus adenofibroma10.1CALCA, NF1
38brain angioma10.1PMP22, SERPINI2, SRPX2, XIRP1
39ureter inverted papilloma10.1CALCA, PMP22
40burns10.1CALCA, TAC1
41neuromuscular disease10.1CALCA, NF1, SEMA3A
42major depressive disorder and accelerated response to antidepressant drug treatment10.0BDNF, CRLF1, GAL
43segmental dystonia10.0OXT, TAC1
44autonomic nervous system neoplasm10.0CALCA, TAC1
45obsessive-compulsive personality disorder10.0OXT, WDFY2
46autoimmune hepatitis9.9BDNF, NF1, OXT
47spinal canal intradural extramedullary neoplasm9.9CALCA, TAC1
48atherosclerosis9.8OXT, WDFY2
49choline deficiency disease7.8AMD1, BDNF, CALCA, CRLF1, GAL, KCNK6

Graphical network of the top 20 diseases related to Brachial Plexus Lesion:



Diseases related to brachial plexus lesion

Symptoms for Brachial Plexus Lesion

About this section

Drugs & Therapeutics for Brachial Plexus Lesion

About this section

Drugs for Brachial Plexus Lesion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Heparinapproved, investigational6729005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
2calcium heparin672
3CalamusNutraceutical312

Interventional clinical trials:

idNameStatusNCT IDPhase
1The Aortic Surgery Cerebral Protection Evaluation (ACE) Randomized TrialRecruitingNCT02554032
2Incidence of Brachial Plexus Injury After Rotator Cuff Repair With Continuous Interscalene BlockWithdrawnNCT01334632

Search NIH Clinical Center for Brachial Plexus Lesion

Genetic Tests for Brachial Plexus Lesion

About this section

Anatomical Context for Brachial Plexus Lesion

About this section

MalaCards organs/tissues related to Brachial Plexus Lesion:

33
Skin, Spinal cord

Animal Models for Brachial Plexus Lesion or affiliated genes

About this section

MGI Mouse Phenotypes related to Brachial Plexus Lesion:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3CALCA, NF1, NLRP3, OXT, SEMA3A, TAC1
2MP:00053857.9CALCA, KCNK6, NF1, NRP1, OXT, SEMA3A
3MP:00107717.6BDNF, CALCA, GAL, NF1, NLRP3, OXT
4MP:00107687.1AMD1, BDNF, CALCA, CRLF1, NF1, NLRP3
5MP:00053787.0BDNF, GAL, NF1, NLRP3, NRP1, OXT
6MP:00053866.9BDNF, CALCA, CRLF1, GAL, NF1, OXT
7MP:00036316.6BDNF, CALCA, CRLF1, GAL, NF1, NLRP3

Publications for Brachial Plexus Lesion

About this section

Articles related to Brachial Plexus Lesion:

(show all 25)
idTitleAuthorsYear
1
Long-term outcome of accessory nerve to suprascapular nerve transfer in obstetric brachial plexus lesion: functional, morphological, and electrophysiological results. (26111514)
2015
2
Explaining daily functioning in young adults with obstetric brachial plexus lesion. (25332088)
2014
3
Ultrasound-guided pulse-dose radiofrequency: treatment of neuropathic pain after brachial plexus lesion and arm revascularization. (25525439)
2014
4
The effect of perinatal brachial plexus lesion on upper limb development. (24694070)
2014
5
A cross-sectional study of hand sensation in adults with conservatively treated obstetric brachial plexus lesion. (23121196)
2013
6
Hand sensation in adults with conservatively treated obstetric brachial plexus lesion. (23163967)
2013
7
Recovery of brachial plexus lesions resulting from heavy backpack use: a follow-up case series. (21429232)
2011
8
Development of a set of activities to evaluate the arm and hand function in children with obstetric brachial plexus lesion. (17264110)
2007
9
Extremity shortness in obstetric brachial plexus lesion and its relationship to root avulsion. (18174555)
2007
10
Detection of root avulsion in the dominant C7 obstetric brachial plexus lesion: experience with three-dimensional constructive interference in steady-state magnetic resonance imaging and electrophysiology. (16284563)
2005
11
Brachial plexus lesion following an anterior dislocation of the shoulder. (15167179)
2004
12
Measuring secondary deformities of the shoulder in children with obstetric brachial plexus lesion: reliability of three methods. (12703037)
2003
13
Retroversion of the humeral head in children with an obstetric brachial plexus lesion. (12043783)
2002
14
Rehabilitation of patient with brachial plexus lesion and break in axillary artery. Case study. (8994018)
1996
15
Repair of ruptured spinal nerve roots in a brachial plexus lesion. Case report. (7897534)
1995
16
Brachial plexus lesions and rhabdomyolysis following heroin abuse. Indications for an immunological cause]. (7828462)
1995
17
A new type of brachial plexus lesion to be added to the classical types. (7718039)
1994
18
A fourth type of brachial plexus lesion: the intermediate (C7) palsy. (1791357)
1991
19
Idiopathic brachial plexus lesion with conduction block of the ulnar nerve. (2465129)
1989
20
Prosthetic rehabilitation in unilateral high above-elbow amputation and brachial plexus lesion: case report. (3964062)
1986
21
A spontaneous relocation of a dislocated Neer prosthesis. Occurs with recovery of brachial plexus lesion. (3453468)
1986
22
Brachial plexus lesion complication sternotomy. (7119825)
1982
23
Successful repair of a complete brachial plexus lesion. (5522062)
1970
24
Brachial plexus lesion. (5612894)
1967
25
Axillary aneurysm associated with a brachial plexus lesion. (5911425)
1966

Variations for Brachial Plexus Lesion

About this section

Expression for genes affiliated with Brachial Plexus Lesion

About this section
Search GEO for disease gene expression data for Brachial Plexus Lesion.

Pathways for genes affiliated with Brachial Plexus Lesion

About this section

Pathways related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6BDNF, NRP1, SEMA3A
29.5NRP1, SEMA3A, SEMA3F

GO Terms for genes affiliated with Brachial Plexus Lesion

About this section

Cellular components related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:00431959.5BDNF, CALCA, OXT
2neuronal cell bodyGO:00430258.8BDNF, CALCA, GAL, TAC1
3axonGO:00304248.4BDNF, CALCA, NF1, NRP1, SEMA3A, TAC1
4extracellular spaceGO:00056156.6BDNF, CALCA, CRLF1, GAL, NRP1, OXT

Biological processes related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1gonadotrophin-releasing hormone neuronal migration to the hypothalamusGO:002182810.7NRP1, SEMA3A
2facioacoustic ganglion developmentGO:190337510.7NRP1, SEMA3A
3regulation of axon extension involved in axon guidanceGO:004884110.6NRP1, SEMA3A
4axonogenesis involved in innervationGO:006038510.6NRP1, SEMA3A
5dichotomous subdivision of terminal units involved in salivary gland branchingGO:006066610.6NRP1, SEMA3A
6trigeminal ganglion developmentGO:006155110.6NRP1, SEMA3A
7axonal fasciculationGO:000741310.4NRP1, SEMA3A
8regulation of long-term neuronal synaptic plasticityGO:004816910.4BDNF, NF1
9motor neuron axon guidanceGO:000804510.3NRP1, SEMA3A
10artery morphogenesisGO:004884410.3NF1, NRP1
11negative regulation of neuroblast proliferationGO:000740610.3BDNF, NF1
12negative regulation of osteoclast differentiationGO:004567110.2CALCA, NF1
13sympathetic nervous system developmentGO:004848510.2NF1, NRP1, SEMA3A
14negative regulation of axon extensionGO:003051710.2NRP1, SEMA3A
15positive regulation of adenylate cyclase activityGO:004576210.2CALCA, NF1
16trigeminal nerve structural organizationGO:002163710.2NRP1, SEMA3A, SEMA3F
17ventral trunk neural crest cell migrationGO:003648610.2NRP1, SEMA3A, SEMA3F
18sympathetic neuron projection extensionGO:009749010.2NRP1, SEMA3A, SEMA3F
19sympathetic neuron projection guidanceGO:009749110.2NRP1, SEMA3A, SEMA3F
20semaphorin-plexin signaling pathway involved in neuron projection guidanceGO:190228510.2NRP1, SEMA3A, SEMA3F
21axon extension involved in axon guidanceGO:004884610.2NRP1, SEMA3A, SEMA3F
22branchiomotor neuron axon guidanceGO:002178510.2NRP1, SEMA3A, SEMA3F
23semaphorin-plexin signaling pathway involved in axon guidanceGO:190228710.2NRP1, SEMA3A, SEMA3F
24facial nerve structural organizationGO:002161210.2NRP1, SEMA3A, SEMA3F
25sympathetic ganglion developmentGO:006154910.1NRP1, SEMA3A, SEMA3F
26neural crest cell migration involved in autonomic nervous system developmentGO:190116610.1NRP1, SEMA3A, SEMA3F
27negative regulation of axon extension involved in axon guidanceGO:004884310.1NRP1, SEMA3A, SEMA3F
28semaphorin-plexin signaling pathwayGO:007152610.1NRP1, SEMA3A, SEMA3F
29response to yeastGO:000187810.1CALCA, TAC1
30antifungal humoral responseGO:001973210.1CALCA, TAC1
31response to painGO:00482659.9CALCA, TAC1
32negative regulation of neuron apoptotic processGO:00435249.8BDNF, CRLF1, NRP1
33feeding behaviorGO:00076319.8BDNF, CALCA, GAL
34nerve developmentGO:00216759.8BDNF, NRP1, SEMA3A, SEMA3F
35positive regulation of synapse assemblyGO:00519659.7BDNF, OXT, SRPX2
36cellular response to nerve growth factor stimulusGO:19900909.7BDNF, CALCA, TAC1
37positive regulation of renal sodium excretionGO:00358159.6OXT, TAC1
38neuropeptide signaling pathwayGO:00072189.6CALCA, GAL, TAC1
39positive regulation of ossificationGO:00457789.4CALCA, OXT, TAC1
40positive regulation of cytosolic calcium ion concentrationGO:00072049.3CALCA, OXT, TAC1
41cell-cell signalingGO:00072679.3BDNF, CALCA, NRP1, TAC1
42inflammatory responseGO:00069549.2CALCA, GAL, NLRP3, TAC1
43regulation of heart rateGO:00020279.2CALCA, OXT, SEMA3A
44heart developmentGO:00075079.0NF1, NRP1, OXT, XIRP1
45axon guidanceGO:00074118.5BDNF, NF1, NRP1, SEMA3A, SEMA3F

Molecular functions related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine bindingGO:001995510.5CRLF1, NRP1
2semaphorin receptor bindingGO:003021510.5SEMA3A, SEMA3F
3neuropilin bindingGO:003819110.5SEMA3A, SEMA3F
4protein bindingGO:00055154.2BDNF, CALCA, CRLF1, GAL, NF1, NLRP3

Sources for Brachial Plexus Lesion

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet