MCID: BRC011
MIFTS: 38

Brachial Plexus Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Brachial Plexus Neuropathy

MalaCards integrated aliases for Brachial Plexus Neuropathy:

Name: Brachial Plexus Neuropathy 12 28 14
Brachial Plexus Neuropathies 41 69
Brachial Plexopathy 12 51
Brachial Plexus Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3690
ICD10 32 G54.0
MeSH 41 D020516
NCIt 46 C27194
SNOMED-CT 64 3548001
UMLS 69 C0700251

Summaries for Brachial Plexus Neuropathy

MalaCards based summary : Brachial Plexus Neuropathy, also known as brachial plexus neuropathies, is related to brachial plexus lesion and neuropathy, hereditary, with liability to pressure palsies, and has symptoms including neuralgia An important gene associated with Brachial Plexus Neuropathy is SEPT9 (Septin 9). The drugs Acetylcholine and Botulinum Toxins have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, breast and bone.

Wikipedia : 72 The brachial plexus is a network of nerves formed by the anterior rami of the lower four cervical nerves... more...

Related Diseases for Brachial Plexus Neuropathy

Diseases related to Brachial Plexus Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 brachial plexus lesion 31.0 SERPINI2 SRPX2 XIRP1
2 neuropathy, hereditary, with liability to pressure palsies 29.8 KIF1B PMP22
3 amyotrophic neuralgia 28.6 DNAH17 KIF1B PMP22 SEC14L1 SEPT9
4 radiation induced brachial plexopathy 12.4
5 amyotrophy, hereditary neuralgic 12.3
6 neuropathy 10.8
7 plexopathy 10.8
8 thoracic outlet syndrome 10.3
9 venous thoracic outlet syndrome 10.1
10 arterial thoracic outlet syndrome 10.1
11 neurogenic thoracic outlet syndrome 10.1
12 osteomyelitis 10.1
13 charcot-marie-tooth disease, demyelinating, type 1b 10.1 KIF1B PMP22
14 charcot-marie-tooth disease, axonal, type 2b 10.0 KIF1B PMP22
15 roussy-levy hereditary areflexic dystasia 10.0 KIF1B PMP22
16 arthritis 10.0
17 septic arthritis 10.0
18 motor peripheral neuropathy 10.0 KIF1B PMP22
19 charcot-marie-tooth disease, demyelinating, type 1a 10.0 KIF1B PMP22
20 charcot-marie-tooth disease, demyelinating, type 1d 10.0 KIF1B PMP22
21 charcot-marie-tooth disease, demyelinating, type 1c 10.0 KIF1B PMP22
22 charcot-marie-tooth disease and deafness 9.9 KIF1B PMP22
23 ulnar neuropathy 9.9 PMP22 SERPINI2
24 hypertrophic neuropathy of dejerine-sottas 9.9 KIF1B PMP22
25 breast cancer 9.9
26 systemic lupus erythematosus 9.9
27 thyroid cancer, nonmedullary, 1 9.9
28 torticollis 9.9
29 arteriovenous fistula 9.9
30 burns 9.9
31 leukemia 9.9
32 lymphoma 9.9
33 ehlers-danlos syndrome 9.9
34 scrub typhus 9.9
35 polyneuropathy 9.9
36 prostatitis 9.9
37 mononeuritis multiplex 9.9
38 cervicitis 9.9
39 seminoma 9.9
40 pneumonia 9.9
41 thyroiditis 9.9
42 macular holes 9.9
43 lupus erythematosus 9.9
44 tracheitis 9.9
45 acute monoblastic leukemia 9.9
46 hereditary neuropathy with liability to pressure palsy 9.9
47 testicular seminoma 9.9
48 hereditary neuropathies 9.9
49 neuropathy, congenital hypomyelinating or amyelinating, autosomal recessive 9.8 KIF1B PMP22
50 charcot-marie-tooth disease, axonal, type 2e 9.8 KIF1B PMP22

Graphical network of the top 20 diseases related to Brachial Plexus Neuropathy:



Diseases related to Brachial Plexus Neuropathy

Symptoms & Phenotypes for Brachial Plexus Neuropathy

UMLS symptoms related to Brachial Plexus Neuropathy:


neuralgia

Drugs & Therapeutics for Brachial Plexus Neuropathy

Drugs for Brachial Plexus Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 Botulinum Toxins Phase 4
3 Cholinergic Agents Phase 4
4 Neurotransmitter Agents Phase 4
5
Clodronate Approved, Investigational, Vet_approved Phase 3 10596-23-3 25419
6
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
7
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
8 Tocopherol Approved, Investigational, Nutraceutical Phase 3
9
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
10 Antioxidants Phase 3
11 Bone Density Conservation Agents Phase 3
12 Micronutrients Phase 3
13 Phosphodiesterase Inhibitors Phase 3
14 Platelet Aggregation Inhibitors Phase 3
15 Protective Agents Phase 3
16 Radiation-Protective Agents Phase 3
17 Tocopherols Phase 3
18 Tocotrienols Phase 3
19 Trace Elements Phase 3
20 Vasodilator Agents Phase 3
21 Vitamins Phase 3
22 Analgesics Phase 2, Phase 3
23 Analgesics, Non-Narcotic Phase 2, Phase 3
24 Anti-Inflammatory Agents Phase 2, Phase 3
25 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
26 Antirheumatic Agents Phase 2, Phase 3
27 Cyclooxygenase Inhibitors Phase 2, Phase 3
28 Peripheral Nervous System Agents Phase 2, Phase 3
29 Tocotrienol Investigational, Nutraceutical Phase 3 6829-55-6

Interventional clinical trials:

(show all 14)

# Name Status NCT ID Phase Drugs
1 Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
2 Trial of Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial Plexopathy Completed NCT01291433 Phase 3 Pentoxifylline placebo;Pentoxifylline;Tocopherol acetate;Clodronic Acid;Tocopherol placebo;Clodronate placebo
3 Hypoalgesic Effect of Neural Mobilization Versus Ibuprofen Pharmacologic Treatment Completed NCT02593721 Phase 2, Phase 3 Ibuprofen
4 Hypoalgesic Effect of Median Nerve Neural Mobilization Compared to a Controlled Group Completed NCT02596815 Phase 2
5 Hypoalgesic Effect of Neural Mobilization Completed NCT02595294 Phase 2
6 Radiation Therapy in Treating Women With Early Stage Breast Cancer Recruiting NCT00909909 Phase 2
7 Thoracic Outlet Syndrome: Case Reports and Analysis With Ultrasound Imaging Completed NCT01196637
8 Longitudinal Experimental Study on ULNTT and Cervico-Thoracic Spine Motion Patterns Relationship Completed NCT02632357
9 GRANVIA®-C Cervical Disc Prosthesis Multicenter European Pilot Study Completed NCT01518582
10 HBOT Late Radiation Tissue Injury Recruiting NCT02425215
11 Hypofractionated Radiotherapy in Breast Cancer Recruiting NCT03167359
12 Outcome of 15 Versus 5 Fractions in Adjuvant Breast Radiotherapy in Women Over 65 Years Recruiting NCT03121248
13 Cervicobrachial Neuralgia and Sagital Balance of the Cervical Spine Recruiting NCT03397459
14 Neuralgic Amyotrophy: Central Reorganization and Rehabilitation After Peripheral Dysfunction Not yet recruiting NCT03441347

Search NIH Clinical Center for Brachial Plexus Neuropathy

Cochrane evidence based reviews: brachial plexus neuropathies

Genetic Tests for Brachial Plexus Neuropathy

Genetic tests related to Brachial Plexus Neuropathy:

# Genetic test Affiliating Genes
1 Brachial Plexus Neuropathy 28

Anatomical Context for Brachial Plexus Neuropathy

MalaCards organs/tissues related to Brachial Plexus Neuropathy:

38
Spinal Cord, Breast, Bone, Prostate, Thyroid

Publications for Brachial Plexus Neuropathy

Articles related to Brachial Plexus Neuropathy:

(show top 50) (show all 78)
# Title Authors Year
1
Dosimetric analysis of the brachial plexus among patients with breast cancer treated with post-mastectomy radiotherapy to the ipsilateral supraclavicular area: report of 3 cases of radiation-induced brachial plexus neuropathy. ( 25499205 )
2014
2
Acute brachial plexus neuropathy with involvement of cranial nerves IX, X, XI and XII. ( 23953851 )
2013
3
Brachial plexus neuropathy secondary to postoperative prone positioning for macular hole surgery. ( 25389684 )
2011
4
Brachial plexus neuropathy resulting from a massively enlarged papillary thyroid carcinoma. ( 19504551 )
2009
5
Electrophysiologic evidence of polyneuropathy in a cat with signs of bilateral brachial plexus neuropathy. ( 19210244 )
2009
6
SEPT9 mutations and a conserved 17q25 sequence in sporadic and hereditary brachial plexus neuropathy. ( 19204161 )
2009
7
Radiation-induced brachial plexus neuropathy - aetiopathogenesis, risk factors, differential diagnostics, symptoms and treatment. ( 17357008 )
2007
8
Recurrent lymphoma presenting as brachial plexus neuropathy. ( 17308278 )
2007
9
Friday night palsy: an unusual case of brachial plexus neuropathy. ( 16412841 )
2006
10
Stent grafting resolved brachial plexus neuropathy due to cervical arteriovenous fistula. ( 15583459 )
2004
11
High dose intravenous immune globulin in the treatment of hereditary recurrent brachial plexus neuropathy. ( 12640095 )
2003
12
Inflammation and neuropathic attacks in hereditary brachial plexus neuropathy. ( 12082044 )
2002
13
Acute sporadic brachial plexus neuropathy. ( 23978864 )
2002
14
Contralateral brachial plexus neuropathy after arthroscopic shoulder surgery. ( 12098130 )
2002
15
Arteritis and brachial plexus neuropathy as delayed complications of radiation therapy. ( 11499827 )
2001
16
Brachial plexus neuropathy. A long-term outcome study. ( 10991813 )
2000
17
Chronic demyelinating hypertrophic brachial plexus neuropathy. ( 10639625 )
2000
18
Recurring brachial plexus neuropathy in a diabetic patient after shoulder surgery and continuous interscalene block. ( 10960400 )
2000
19
Brachial plexus neuropathy as unusual onset of diffuse neurolymphomatosis. ( 11214664 )
2000
20
Brachial plexus neuropathy: a rare complication of patient positioning during interventional radiologic procedures. ( 10357484 )
1999
21
Herpetic tracheitis and brachial plexus neuropathy in a child with burns. ( 10501325 )
1999
22
Acquired brachial-plexus neuropathy in the neonate: a rare presentation of late-onset group-B streptococcal osteomyelitis. ( 9698064 )
1998
23
Brachial plexus neuropathy following mantle radiotherapy. ( 9890543 )
1998
24
Acute brachial plexus neuropathy as a presenting sign of peripheral nervous system involvement in paraproteinaemia. ( 9188910 )
1997
25
Brachial plexus neuropathy after botulinum toxin injection. ( 9339718 )
1997
26
Chronic relapsing brachial plexus neuropathy with persistent conduction block. ( 9324087 )
1997
27
Septic arthritis associated with brachial plexus neuropathy. A case report. ( 8550666 )
1996
28
Brachial plexus neuropathy after radiotherapy can be treated by specialist surgeons. ( 8605493 )
1996
29
Mapping of hereditary neuralgic amyotrophy (familial brachial plexus neuropathy) to distal chromosome 17q. ( 8780104 )
1996
30
Brachial plexus neuropathy following attempt at subclavian vein catheterization. Case report. ( 8829409 )
1996
31
Immune brachial plexus neuropathy: suggestive evidence for an inflammatory-immune pathogenesis. ( 8614534 )
1996
32
Management of radiation-induced brachial plexus neuropathy. Royal College Radiologists. ( 8738825 )
1996
33
Hereditary neuropathy with liability to pressure palsies and inherited brachial plexus neuropathy--two genetically distinct disorders. ( 7630211 )
1995
34
Postoperative brachial plexus neuropathy after total knee replacement under spinal anaesthesia. ( 7577297 )
1995
35
Audit of brachial plexus neuropathy following radiotherapy. ( 8845319 )
1995
36
Brachial plexus neuropathy after radiotherapy for breast cancer. ( 8520378 )
1995
37
Brachial plexus neuropathy secondary to septic arthritis and osteomyelitis: report of two cases. ( 7942033 )
1994
38
Anti-peripheral nerve myelin antibodies and terminal activation products of complement in serum of patients with acute brachial plexus neuropathy. ( 8257306 )
1993
39
Brachial plexus neuropathy associated with scrub typhus: report of a case. ( 1352327 )
1992
40
Anticoagulant-induced shoulder hematoma producing brachial plexus neuropathy--case reports. ( 1321570 )
1992
41
MRI scanning in brachial plexus neuropathy. ( 1667466 )
1991
42
Brachial plexus neuropathy. ( 1848287 )
1991
43
Acute brachial plexus neuropathy secondary to halo-gravity traction in a patient with Ehlers-Danlos syndrome. ( 1851333 )
1991
44
Clinical and electrodiagnostic findings in breast cancer patients with radiation-induced brachial plexus neuropathy. ( 2327236 )
1990
45
Radiation-induced brachial plexus neuropathy in breast cancer patients. ( 2261203 )
1990
46
Recurrent brachial plexus neuropathy and giant cell arteritis. ( 2154359 )
1990
47
Acute ischemic brachial plexus neuropathy following radiation therapy. ( 2927663 )
1989
48
Brachial plexus neuropathy. ( 2710149 )
1989
49
Brachial plexus neuropathy in a gymnast associated with chicken pox. ( 2560941 )
1989
50
Mononeuritis multiplex with brachial plexus neuropathy coincident with Mycoplasma pneumoniae infection. ( 2540009 )
1989

Variations for Brachial Plexus Neuropathy

Expression for Brachial Plexus Neuropathy

Search GEO for disease gene expression data for Brachial Plexus Neuropathy.

Pathways for Brachial Plexus Neuropathy

GO Terms for Brachial Plexus Neuropathy

Cellular components related to Brachial Plexus Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axoneme GO:0005930 9.16 DNAH17 SEPT9
2 microtubule GO:0005874 9.13 DNAH17 KIF1B SEPT9
3 stress fiber GO:0001725 8.62 SEPT9 XIRP1

Biological processes related to Brachial Plexus Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule-based movement GO:0007018 8.62 DNAH17 KIF1B

Molecular functions related to Brachial Plexus Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 motor activity GO:0003774 8.96 DNAH17 KIF1B
2 microtubule motor activity GO:0003777 8.62 DNAH17 KIF1B

Sources for Brachial Plexus Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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