Brachydactyly disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

MCID: BRC006 MIFTS: 48	Brachydactyly malady
90 genes, 4 tissues, 465 related diseases, clinical trials.

Summaries for Brachydactyly

Sources:
⁴²NIH Rare Diseases, ⁶³Wikipedia, ⁴⁶OMIM, ³²MalaCards
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NIH Rare Diseases:⁴² Brachydactyly is a general term characterized by disproportionately short fingers and toes. it can occur as an isolated finding or as part of a complex syndrome. many different types of brachydactyly have been identified. some result in short stature and others are associated with other hand malformations, such as syndactyly, polydactyly, or reduction defects. the underlying genetic cause of most isolated forms of brachydactyly and many of the syndromic forms has been identified. many of the isolated forms are inherited in an autosomal dominant manner with variable expressivity and reduced penetrance. treatment depends on the specific type of brachydactyly, but may include plastic surgery, physical therapy and/or ergotherapy. last updated: 9/4/2013

MalaCards: Brachydactyly is related to brachydactyly type a1 and brachydactyly type a2. An important gene associated with Brachydactyly is GDF5 (growth differentiation factor 5), and among its related pathways are Signaling events mediated by the Hedgehog family and TGF-beta Signaling Pathway. The compound cyclopamine have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and thyroid, and related mouse phenotypes are vision/eye and limbs/digits/tail.

Wikipedia:⁶³ Brachydactyly (Greek βραχύς = \"short\" plus δάκτυλος = \"finger\"), is a medical term... more...

Description from OMIM:⁴⁶ 112500, 611377, 113100, 113300, 113000 113200, 613382, 112600 more

Aliases & Classifications for Brachydactyly

Sources:
⁸Disease Ontology, ⁴²NIH Rare Diseases, ¹⁰DISEASES, ⁴⁴Novoseek, ⁶⁰UMLS, ⁴⁶OMIM
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Aliases & Descriptions:

brachydactyly ⁸ ⁴² ¹⁰ ⁴⁴ ⁶⁰

External Ids:

Disease Ontology⁸ DOID:0050581

OMIM⁴⁶ 112500, 611377, 113100 113300, 113000, 113200, 613382, 112600, more

Related Diseases for Brachydactyly

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
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Diseases in the Brachydactyly Type A1 family:

brachydactyly	Brachydactyly Type A5
Brachydactyly Type A2	Brachydactyly Type A3
Brachydactyly Type A4	Brachydactyly Type A6
Brachydactyly Type C	Brachydactyly Type A7
Brachydactyly Type B	Brachydactyly Type E
Brachydactyly Type A1, B	Hoxd13-Related Brachydactyly
Brachydactyly, Type B2	Brachydactyly, Type E2
Brachydactyly, Type B1	Brachydactyly Type D
Brachydactyly, Type A1, C	Brachydactyly of Toes

Diseases related to Brachydactyly via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 465)

id	Related Disease	Score	Top Affiliating Genes
1	brachydactyly type a1	30.4	BDA1B, IHH
2	brachydactyly type a2	30.4	BMPR1B, GDF5
3	brachydactyly-syndactyly syndrome	30.3	LPCAT3, HOXD13
4	syndactyly	30.2	BMPR1B, GDF5, HOXD13, HOXD12, ROR2, NOG
5	polydactyly	30.0	HOXD12, HOXD11, HOXD13, IHH
6	brachydactyly type b	30.0	ROR2, NOG
7	dwarfism	29.9	PTHLH
8	proximal symphalangism	29.8	GDF5, NOG
9	hypertension	10.4
10	temtamy preaxial brachydactyly syndrome	10.3
11	fibular hypoplasia and complex brachydactyly	10.3
12	cryptomicrotia brachydactyly syndrome	10.3
13	brachydactyly type c	10.2
14	hirschsprung disease type d brachydactyly	10.2
15	brachydactyly, type b2	10.2
16	coloboma of macula with type b brachydactyly	10.2
17	brachydactyly type a4	10.2
18	brachydactyly type a5	10.2
19	brachydactyly types b and e combined	10.2
20	brachydactyly long thumb type	10.2
21	sugarman brachydactyly	10.1
22	brachydactyly type e	10.1
23	spondyloepiphyseal dysplasia-brachydactyly and distinctive speech	10.1
24	brachydactyly, type b1	10.1
25	2q37 microdeletion syndrome	10.1
26	brachydactyly mononen type	10.1
27	exostoses anetodermia brachydactyly type e	10.1
28	brachydactyly type d	10.1
29	digital arthropathy-brachydactyly, familial	10.1
30	anonychia-onychodystrophy with brachydactyly type b and ectrodactyly	10.1
31	brachydactyly type a6	10.1
32	brachydactyly with hypertension	10.1
33	brachydactyly type a7	10.1
34	thumb stiff brachydactyly mental retardation	10.1
35	metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	10.1
36	growth deficiency - brachydactyly - dysmorphism	10.1
37	ulnar/fibula ray defect - brachydactyly	10.1
38	microcephaly	10.0
39	craniosynostosis	10.0
40	paraplegia	10.0
41	pseudohypoparathyroidism	10.0
42	brachydactyly type a3	10.0
43	biemond syndrome	10.0
44	stratton-garcia-young syndrome	10.0
45	metaphyseal dysplasia maxillary hypoplasia brachydactyly	10.0
46	brachydactyly type a1, b	10.0
47	brachydactyly, type e2	10.0
48	liebenberg syndrome	10.0
49	weill-marchesani syndrome 1, recessive	10.0
50	chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	10.0

Graphical network of the top 20 diseases related to Brachydactyly:

Clinical Features for Brachydactyly

Sources:
⁴⁶OMIM
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Clinical features from OMIM:

112500,611377,113100,113300,113000,113200,613382,112600

Drugs & Therapeutics for Brachydactyly

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

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Drug clinical trials:

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Genetic Tests for Brachydactyly

Anatomical Context for Brachydactyly

Sources:
³²MalaCards
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MalaCards organs/tissues related to Brachydactyly:

³²

Bone, Heart, Thyroid, Testes

Animal Models for Brachydactyly or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Brachydactyly:

³⁶ (show all 13)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	vision/eye phenotype	MP:0005391	10.6	BMPR1B, CHSY1, IHH, HOXD13, ROR2, NOG
2	limbs/digits/tail phenotype	MP:0005371	10.5	PTHLH, BMPR1B, CHSY1, IHH, GDF5, HOXD13
3	reproductive system phenotype	MP:0005389	10.5	BMPR1B, GDF5, HOXD13, HOXD10, HOXD11, HOXD9
4	skeleton phenotype	MP:0005390	10.5	HOXD13, GDF5, IHH, CHSY1, BMPR1B, HOXD10
5	endocrine/exocrine gland phenotype	MP:0005379	10.5	BMPR1B, IHH, HOXD13, HOXD9, ROR2, NOG
6	craniofacial phenotype	MP:0005382	10.5	BMPR1B, CHSY1, IHH, ROR2, NOG, PTHLH
7	nervous system phenotype	MP:0003631	10.5	BMPR1B, IHH, HOXD13, HOXD10, HOXD11, HOXD9
8	mortality/aging	MP:0010768	10.5	HOXD10, HOXD13, GDF5, IHH, BMPR1B, HOXD11
9	embryogenesis phenotype	MP:0005380	10.4	BMPR1B, IHH, HOXD13, HOXD11, HOXD12, ROR2
10	muscle phenotype	MP:0005369	10.4	NOG, HOXD12, HOXD9, HOXD10, HOXD13, IHH
11	renal/urinary system phenotype	MP:0005367	10.4	HOXD13, HOXD10, HOXD11, HOXD9, NOG, PTHLH
12	cellular phenotype	MP:0005384	10.2	BMPR1B, IHH, HOXD10, HOXD11, HOXD9, EIF6
13	digestive/alimentary phenotype	MP:0005381	10.1	IHH, HOXD13, HOXD12, ROR2, NOG, PTHLH

Publications for Brachydactyly

Sources:
⁵⁰PubMed
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Articles related to Brachydactyly:

(show top 50) (show all 300)

id	Title	Authors	Year
1	Brachydactyly E: isolated or as a feature of a syndrome. (24028571)	Pereda A.... Perez de Nanclares G.	2013
2	A nonsense mutation in the gene ROR2 underlying autosomal dominant brachydactyly type B. (23238279)	Habib R.... Ahmad W.	2013
3	Identification of a GDF5 mutation in a Korean patient with brachydactyly type C without foot involvement. (23483675)	Seo S.H.... Seong M.W.	2013
4	Prenatal diagnosis of a family affected by brachydactyly type A1 with a mutation in IHH: a useful lesson. (22406540)	Palka C.... Stuppia L.	2012
5	Dose dependent expression of HDAC4 causes variable expressivity in a novel inherited case of brachydactyly mental retardation syndrome. (22753018)	Morris B.... Elsea S.H.	2012
6	Takotsubo syndrome and brachydactyly: a new heart-hand syndrome? (21448545)	Danese C.... Amato S.	2011
7	Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels. (21537345)	Ma G.... He L.	2011
8	Mutation analysis of the pathogenic gene in a Chinese family with Brachydactyly type B1]. (21377971)	Li C.M.... Feng H.G.	2011
9	Retraction: Clinical features study of a brachydactyly type A1 family and the disease-causing gene location. (19806586)	Ke X.	2009
10	A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes. (19640924)	Schwarzer W.... Stricker S.	2009
11	Duplications of noncoding elements 5' of SOX9 are associated with brachydactyly-anonychia. (19639023)	Kurth I.... Mundlos S.	2009
12	Clinical investigation of a family with brachydactyly type A1 and the identification of the disease gene]. (19504437)	Ke X.... Liu Q.J.	2009
13	A novel patient with Cooks syndrome supports splitting from "classic" brachydactyly type B. (17163524)	Castori M.... Dallapiccola B.	2007
14	Brachydactyly short-stature hypertension syndrome: a case with associated vascular malformations. (16369843)	Derbent M.... SaatAsi U.	2006
15	A novel heterozygous mutation in the Indian hedgehog gene (IHH) is associated with brachydactyly type A1 in a Chinese family. (16871364)	Liu M.... Wang Q.K.	2006
16	An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression. (15841179)	Niedermaier M.... Mundlos S.	2005
17	Short stature, type E brachydactyly, exostoses, gynecomastia, and cryptorchidism in a patient with 47,XYY/45,X/46,XY mosaicism. (15832105)	Monastirli A.... Tsambaos D.	2005
18	Craniofacial anomalies, deafness, brachydactyly, short stature, and moderate mental retardation due to a cryptic 6p;11q translocation. (11857553)	MAcgarbanAc A.... Le Merrer M.	2002
19	Differences in complexity of isolated brachydactyly type C cannot be attributed to locus heterogeneity alone. (11169564)	Galjaard R.J.... Heutink P.	2001
20	Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B. (10986040)	Schwabe G.C.... Mundlos S.	2000
21	Brachydactyly type B: linkage to chromosome 9q22 and evidence for genetic heterogeneity. (9973296)	Oldridge M.... Wilkie A.O.	1999
22	Clinical and molecular studies of brachydactyly type D. (10398270)	Robin N.H.... Morrison S.	1999
23	A boy with severe manifestations of type A1 brachydactyly. (9546826)	Slavotinek A.... Donnai D.	1998
24	Absence of hypertensive retinopathy in a Turkish kindred with autosomal dominant hypertension and brachydactyly. (9930264)	Hattenbach L.O.... Luft F.C.	1998
25	Families with autosomal dominant brachydactyly type E, short stature, and severe hypertension. (9696728)	Toka H.R.... Luft F.C.	1998
26	Brachydactyly in a child with duplication-deficiency subsequent to t(15;20)(q25.2;p12.2)mat. Candidate regions on one or both chromosomes? (9212188)	Pfeiffer R.A.... Trautmann U.	1997
27	Brachydactyly and short stature in a mother and her daughter with a fragile site at 16q22. (9219009)	Stoll C.... Alembik Y.	1997
28	Congenital cataract and familial brachydactyly in carbohydrate-deficient glycoprotein syndrome. (8739978)	Skladal D.... Bachmann C.	1996
29	Exencephaly in autosomal dominant brachydactyly syndrome. (7740003)	Stagiannis K.D.... Fisk N.M.	1995
30	De novo apparently balanced reciprocal translocation between 5q11.2 and 17q23 associated with Klippel-Feil anomaly and type A1 brachydactyly. (7677149)	Fukushima Y.... Aihara T.	1995
31	Characteristic facies in type B brachydactyly? (7981857)	Houlston R.S.... Temple I.K.	1994
32	A distinct autosomal dominant craniosynostosis-brachydactyly syndrome. (7981856)	Glass I.A.... Hockley A.D.	1994
33	Can cytomegalovirus cause brachydactyly? A case report and review of the literature. (8392455)	Cinbis M.... Balci S.	1993
34	Brachydactyly in acrosyndactyly. (1847397)	Burgess R.C.	1991
35	Type A1 brachydactyly, dwarfism, ptosis, mixed partial hearing loss, microcephaly, and mental retardation. (2750787)	Tsukahara M.... Kajii T.	1989
36	Brachydactyly, a possible inherited anomaly at prehistoric Prince Rupert Harbour. (3046372)	Cybulski J.S.	1988
37	Autosomal dominant onychodystrophy and anonychia with type B brachydactyly and ectrodactyly. (3780038)	Kumar D.... Levick R.K.	1986
38	Familial colorectal cancer and hereditary brachydactyly. (6784851)	Macrae F.A.... St John D.J.	1981
39	Retinitis pigmentosa, metaphyseal chondrodysplasia, and brachydactyly: an affected brother and sister. (7252997)	Phillips C.I.... Newton M.	1981
40	Brachydactyly type E: A report of a family. (7404233)	Cartwright J.D.... Robertson C.	1980
41	Brachydactyly and polydactyly with dermal ridge dissociation and ridge hypoplasia. (513089)	Crawfurd M.D.... SaldaA+a-Garcia P.	1979
42	Brachydactyly C, short stature, and hip dysplasia. (391043)	Fitch N.... Costom B.	1979
43	The pattern of shortening of the bones of the hand in PHP and PPHP--A comparison with brachydactyly E, Turner Syndrome, and acrodysostosis. (870942)	Poznanski A.K.... Shaw H.	1977
44	Brachydactyly and pseudo-pseudohypoparathyroidism. (5703222)	Hertzog K.P.	1968
45	Hereditary brachydactyly and hip disease. Unusual radiological and dermatoglyphic findings in a kindred. (5647298)	ROBINSON G.C.... Baillie J.	1968
46	Hereditary brachydactyly. (5961825)	Hoefnagel D.... Gerald P.S.	1966
47	Spherophakia with brachydactyly; comparison with Marfan's syndrome. (13104565)	PROBERT L.A.	1953
48	A case of brachydactyly (type Brailsford). (14895884)	KEIZER D.P.	1951
49	Variability in the expression of the gene for brachydactyly in man. (20281720)	McNUTT C.W.	1946
50	Familial Occurrence of Microcorneae Associated with Brachydactyly. (19989596)	Tizzard T.	1933

Genes related to Brachydactyly

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Brachydactyly:

(show top 50) (show all 90)

id	Symbol	Description	Score	Implication
1	GDF5	growth differentiation factor 5	20.13	GeneCards inferred : Publications, Disorders, Summaries (show sections)
2	ROR2	receptor tyrosine kinase-like orphan receptor 2	19.91	GeneCards inferred : Summaries, Publications, Disorders (show sections)
3	IHH	indian hedgehog	19.68	GeneCards inferred : Publications, Disorders, Summaries (show sections)
4	CHSY1	chondroitin sulfate synthase 1	19.46	GeneCards inferred : Publications, Disorders, Summaries (show sections)
5	HOXD13	homeobox D13	19.23	GeneCards inferred : Publications, Disorders (show sections)
6	NOG	noggin	19.00	GeneCards inferred : Publications, Disorders (show sections)
7	BMPR1B	bone morphogenetic protein receptor, type IB	18.78	GeneCards inferred : Publications, Disorders (show sections)
8	PTHLH	parathyroid hormone-like hormone	18.56	GeneCards inferred : Publications, Disorders (show sections)
9	HOXD10	homeobox D10	18.33	GeneCards inferred : Publications, Disorders (show sections)
10	FGD1	FYVE, RhoGEF and PH domain containing 1	18.11	GeneCards inferred : Disorders (show sections)
11	MBOAT1	membrane bound O-acyltransferase domain containing 1	17.90	GeneCards inferred : Publications, Disorders, Summaries (show sections)
12	BDA1B	Brachydactyly, type A1, locus B	17.68	GeneCards inferred : Publications, Disorders, Gene name (show sections)
13	CPBHM	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	17.45	GeneCards inferred : Disorders, Gene name (show sections)
14	HTNB	hypertension with brachydactyly	17.23	GeneCards inferred : Disorders, Gene name (show sections)
15	BDMR	brachydactyly-mental retardation syndrome	17.01	GeneCards inferred : Publications, Disorders, Gene name (show sections)
16	HOXD12	homeobox D12	16.77	GeneCards inferred : Publications, Disorders (show sections)
17	HOXD9	homeobox D9	16.55	GeneCards inferred : Publications, Disorders (show sections)
18	HOXD11	homeobox D11	16.33	GeneCards inferred : Publications, Disorders (show sections)
19	EIF6	eukaryotic translation initiation factor 6	16.11	GeneCards inferred : Disorders (show sections)
20	LPCAT3	lysophosphatidylcholine acyltransferase 3	15.88	GeneCards inferred : Disorders (show sections)
21	CASD1	CAS1 domain containing 1	15.66	GeneCards inferred : Disorders (show sections)
22	SHH	sonic hedgehog	15.44	GeneCards inferred : Publications, Disorders (show sections)
23	COL2A1	collagen, type II, alpha 1	15.22	GeneCards inferred : Publications, Disorders (show sections)
24	COMP	cartilage oligomeric matrix protein	14.99	GeneCards inferred : Disorders (show sections)
25	TRPV4	transient receptor potential cation channel, subfamily V, member 4	14.77	GeneCards inferred : Disorders (show sections)
26	REN	renin	14.55	GeneCards inferred : Publications, Disorders (show sections)
27	FGFR3	fibroblast growth factor receptor 3	14.33	GeneCards inferred : Publications, Disorders (show sections)
28	BMPR1A	bone morphogenetic protein receptor, type IA	14.11	GeneCards inferred : Publications, Disorders (show sections)
29	BMP2	bone morphogenetic protein 2	13.88	GeneCards inferred : Publications, Disorders (show sections)
30	EPHA7	EPH receptor A7	13.66	GeneCards inferred : Publications, Disorders (show sections)
31	PTCH1	patched 1	13.44	GeneCards inferred : Disorders (show sections)
32	GNAS	GNAS complex locus	13.22	GeneCards inferred : Publications, Disorders (show sections)
33	RUNX2	runt-related transcription factor 2	12.99	GeneCards inferred : Publications, Disorders (show sections)
34	HDAC4	histone deacetylase 4	12.77	GeneCards inferred : Publications, Disorders (show sections)
35	TRPS1	trichorhinophalangeal syndrome I	12.55	GeneCards inferred : Disorders (show sections)
36	ADCY10	adenylate cyclase 10 (soluble)	12.33	GeneCards inferred : Disorders (show sections)
37	APC	adenomatous polyposis coli	12.11	GeneCards inferred : Publications, Disorders (show sections)
38	FAM58A	family with sequence similarity 58, member A	11.88	GeneCards inferred : Disorders (show sections)
39	MIR17HG	miR-17-92 cluster host gene (non-protein coding)	11.66	GeneCards inferred : Disorders (show sections)
40	LBX1	ladybird homeobox 1	11.43	GeneCards inferred : Publications, Disorders (show sections)
41	PORCN	porcupine homolog (Drosophila)	11.21	GeneCards inferred : Disorders (show sections)
42	PRPS1L1	phosphoribosyl pyrophosphate synthetase 1-like 1	10.99	GeneCards inferred : Disorders (show sections)
43	FERD3L	Fer3-like (Drosophila)	10.77	GeneCards inferred : Disorders (show sections)
44	HOXA13	homeobox A13	10.54	GeneCards inferred : Disorders (show sections)
45	HEMK1	HemK methyltransferase family member 1	10.32	GeneCards inferred : Disorders (show sections)
46	STX16	syntaxin 16	10.10	GeneCards inferred : Disorders (show sections)
47	OFD1	oral-facial-digital syndrome 1	9.88	GeneCards inferred : Disorders (show sections)
48	CENPL	centromere protein L	9.66	GeneCards inferred : Disorders (show sections)
49	NPR2	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	9.43	GeneCards inferred : Disorders (show sections)
50	GPC1	glypican 1	9.21	GeneCards inferred : Disorders (show sections)

Products for genes related to Brachydactyly disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	45	45	44
2	LSBio	-	-	50

Genetic Variations for Brachydactyly

Expression for genes affiliated with Brachydactyly

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Brachydactyly

Search GEO for disease gene expression data for Brachydactyly.

Pathways for genes affiliated with Brachydactyly

Sources:
³⁷NCBI BioSystems Database, ⁵⁵SinoBiological, ²⁹KEGG
See all sources

Pathways related to Brachydactyly according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Signaling events mediated by the Hedgehog family³⁷	10.4	PTHLH, IHH
2	TGF-beta Signaling Pathway⁵⁵	10.4	NOG, GDF5, BMPR1B
3	TGF-beta signaling pathway²⁹	10.4	NOG, GDF5, BMPR1B

Compounds for genes affiliated with Brachydactyly

Sources:
⁴⁴Novoseek, ⁵⁹Tocris Bioscience
See all sources

Compounds related to Brachydactyly according to GeneCards/GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	cyclopamine⁴⁴ ⁵⁹	11.4	NOG, IHH

GO Terms for genes affiliated with Brachydactyly

Sources:
¹⁶Gene Ontology
See all sources

Biological processes related to Brachydactyly according to GeneCards/GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	hindlimb morphogenesis	GO:035137	10.7	HOXD9, HOXD10, GDF5
2	embryonic digit morphogenesis	GO:042733	10.7	HOXD13, HOXD11, HOXD12, NOG
3	cartilage development	GO:051216	10.7	NOG, GDF5, IHH
4	skeletal system development	GO:001501	10.7	PTHLH, NOG, HOXD12, HOXD13, IHH, BMPR1B
5	somite development	GO:061053	10.7	IHH, NOG
6	dorsal/ventral pattern formation	GO:009953	10.7	BMPR1B, HOXD11, NOG
7	proximal/distal pattern formation	GO:009954	10.7	HOXD9, HOXD11, HOXD10
8	anterior/posterior pattern specification	GO:009952	10.7	HOXD13, HOXD10, HOXD11, HOXD9
9	forelimb morphogenesis	GO:035136	10.7	HOXD10, GDF5
10	peripheral nervous system neuron development	GO:048935	10.6	HOXD9, HOXD10
11	embryonic skeletal joint morphogenesis	GO:060272	10.6	HOXD11, NOG
12	positive regulation of chondrocyte differentiation	GO:032332	10.6	HOXD11, GDF5
13	phosphatidylserine acyl-chain remodeling	GO:036150	10.5	LPCAT3, MBOAT1
14	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.5	IHH, HOXD13, HOXD10, HOXD9, NOG
15	cartilage condensation	GO:001502	10.5	ROR2, BMPR1B
16	embryonic forelimb morphogenesis	GO:035115	10.4	HOXD9, HOXD11
17	phosphatidylethanolamine acyl-chain remodeling	GO:036152	10.3	LPCAT3, MBOAT1
18	multicellular organismal development	GO:007275	10.1	HOXD13, HOXD12, FGD1, ROR2