MCID: BRN028
MIFTS: 65

Brain Cancer malady

Cancer, Neuronal categories

Summaries for Brain Cancer

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Cancer of the brain is usually called a brain tumor. there are two main types. a primary brain tumor starts in the brain. a metastatic brain tumor starts somewhere else in the body and moves to the brain. brain tumors can be benign, with no cancer cells, or malignant, with cancer cells that grow quickly. brain tumors can cause many symptoms. some of the most common are headaches, usually worse in the morning nausea and vomiting changes in your ability to talk, hear, or see problems with balance or walking problems with thinking or memory muscle jerking or twitching numbness or tingling in arms or legs doctors diagnose brain tumors by doing a neurologic exam and tests including an mri, ct scan, and biopsy. people with brain tumors have several treatment options. the options are surgery, radiation therapy, and chemotherapy. many people get a combination of treatments. nih: national cancer institute

MalaCards: Brain Cancer, also known as adult brain tumor, is related to adenocarcinoma and colorectal cancer. An important gene associated with Brain Cancer is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs carmustine and etoposide and the compounds vegf and ly294002 have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and spinal cord, and related mouse phenotypes are cellular and reproductive system.

Wikipedia:64 A brain tumor or brain tumour, is an intracranial solid neoplasm, a tumor (defined as an abnormal growth... more...

Aliases & Classifications for Brain Cancer

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

brain cancer 8 10 45 34
adult brain tumor 8 45 61
primary malignant neoplasm of brain 8 61
neoplasm of unspecified nature of brain 8
malignant primary brain neoplasm 8
malignant primary brain tumors 45
malignant tumor of adult brain 8
adult malignant brain neoplasm 8
malignant primary brain tumor 8
malignant neoplasm of brain 61
malignant tumor of brain 8
malignant brain tumour 8
primary brain neoplasm 8
brain neoplasm, adult 8
brain tumor, primary 61
brain tumor primary 45
primary brain tumor 8
tumor of the brain 8
brain tumor, adult 43
bt - brain tumour 8
neoplasm of brain 8
brain neoplasms 61
brain neoplasm 8
brain tumors 45
brain ca 8


Related Diseases for Brain Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Brain Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.1PDGFRB, CT49, EGFR, PRDX4, BAX, INSR
2colorectal cancer29.8PDGFRB, CT49, EGFR, VEGFB, BAX, INSR
3astrocytoma29.8PDGFRB, CT49, EGFR, IL13
4rhabdoid tumor10.6
5gliosarcoma10.3
6atypical teratoid rhabdoid tumor10.3
7brain glioma10.3
8brain meningioma10.3
9anaplastic astrocytoma10.3
10brain stem neoplasm10.2
11brain ependymoma10.2
12ependymoma10.2
13oligoastrocytoma10.2
14brain disease10.2
15juvenile pilocytic astrocytoma10.2
16juvenile astrocytoma10.2
17pilocytic astrocytoma10.2
18pseudotumor cerebri10.1
19foot drop10.1
20brain glioblastoma multiforme10.1
21intracranial aneurysm10.1
22pediatric ependymoma10.1
23ganglioglioma10.1
24childhood germ cell brain tumor10.1
25li-fraumeni syndrome10.1
26acute leukemia10.1
27aphasia10.1
28brain stem glioma10.1
29diencephalic syndrome10.1
30brain tumor-polyposis syndrome 210.1
31neurofibromatosis10.1
32hepatitis c10.1
33hepatitis e10.1
34appendicitis10.1
35hepatitis b10.1
36hepatitis d10.1
37hepatitis c virus10.1
38acoustic neuroma10.1
39melanotic neuroectodermal tumor10.0
40oculocerebrorenal syndrome10.0
41thyroid medullary carcinoma10.0
42hydranencephaly10.0
43turner syndrome10.0
44lymphedema-distichiasis syndrome10.0
45heart defect, tongue hamartoma and polysyndactyly10.0
46hennekam syndrome10.0
47median cleft of upper lip with polyps of facial skin and nasal mucosa10.0
48glioma somatic10.0
49myofibromatosis, infantile, 110.0
50mixed germ cell tumor10.0

Graphical network of the top 20 diseases related to Brain Cancer:



Diseases related to brain cancer

Clinical Features for Brain Cancer

Drugs & Therapeutics for Brain Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Brain Cancer

Anatomical Context for Brain Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Brain Cancer:

33
Whole blood, Brain, Spinal cord, Small intestine, Colon, Kidney, Liver, Lung, Thyroid, Salivary gland, Breast, Skin, Prostate, Testis, Cervix, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid, Testis germ

Animal Models for Brain Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Brain Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.4INSR, NANOG, BAX, PRDX4, EGFR, ARHGAP1
2MP:000538911.2PDGFRB, IL13, INSR, BAX, VEGFB, PRDX4
3MP:000537910.6PDGFRB, CRYM, PRDX4, BAX

Publications for Brain Cancer

Sources:
51PubMed
See all sources

Articles related to Brain Cancer:

(show top 50)    (show all 585)
idTitleAuthorsYear
1
Reduced Risk of Brain Cancer Mortality from Walking and Running. (24091993)
2013
2
The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in brain cancer. (23624825)
2013
3
Validation of the Korean version of the European Organization for Research and Treatment of Cancer brain cancer module (EORTC QLQ-BN20) in patients with brain tumors. (23981813)
2013
4
Sulfasalazine for brain cancer fits. (22404218)
2012
5
Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on the brain distribution of a novel BRAF inhibitor: vemurafenib (PLX4032). (22454535)
2012
6
Stereotactic radiosurgery (SRS) and the management of metastatic brain cancer. Introduction. (22334944)
2012
7
Brain cancer mortality among farm workers of the State of Rio de Janeiro, Brazil: a population-based case-control study, 1996-2005. (22118878)
2012
8
Multidrug resistance gene (MDR-1) and risk of brain metastasis in epithelial ovarian, fallopian tube, and peritoneal cancer. (20921883)
2011
9
Nanog-induced dedifferentiation of p53-deficient mouse astrocytes into brain cancer stem-like cells. (21810410)
2011
10
Targeted extracellular nanoparticles enable intracellular detection of activated epidermal growth factor receptor in living brain cancer cells. (21683807)
2011
11
A chitosan/beta-glycerophosphate thermo-sensitive gel for the delivery of ellagic acid for the treatment of brain cancer. (20185170)
2010
12
Low ultraviolet B and increased risk of brain cancer: an ecological study of 175 countries. (20948235)
2010
13
DRR drives brain cancer invasion by regulating cytoskeletal-focal adhesion dynamics. (20543869)
2010
14
Temozolomide: Expanding its role in brain cancer. (21225022)
2010
15
Genetically engineered mouse models of brain cancer and the promise of preclinical testing. (19076778)
2009
16
Survival among women with triple receptor-negative breast cancer and brain metastases. (19150943)
2009
17
Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets. (19049606)
2008
18
Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group Study. (18824712)
2008
19
Extended survival in women with brain metastases from HER2 overexpressing breast cancer. (18525303)
2008
20
Selective cancer-germline gene expression in pediatric brain tumors. (18398575)
2008
21
Rehabilitation after brain cancer surgery. (17348372)
2007
22
Propolin G, a prenylflavanone, isolated from Taiwanese propolis, induces caspase-dependent apoptosis in brain cancer cells. (17685631)
2007
23
Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair. (17174478)
2007
24
Towards hyperpolarized (13)C-succinate imaging of brain cancer. (17303454)
2007
25
Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. (16709014)
2006
26
Future prospects for the cure of brain cancer. (16700614)
2006
27
Differential reactions of microglia to brain metastasis of lung cancer. (17088948)
2006
28
Inhibitory effect of human brain myelin basic protein on H2O2-induced apoptosis of human lung cancer cell line YTLMC-90]. (16480580)
2006
29
Stem cells and brain cancer. (16123777)
2006
30
Aggressive G-CSF-producing gastric cancer complicated by lung and brain abscesses, mimicking metastases. (16086124)
2005
31
Occupational risk factors for brain cancer in Canada. (16010197)
2005
32
Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma. (15671553)
2005
33
Brain metastasis from colorectal cancer. (15309466)
2005
34
Brain-cancer stem cells may drive tumour formation. (15645592)
2005
35
New drug extends lives of brain cancer patients. (16252389)
2005
36
The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients. (15805252)
2005
37
Imaging endogenous gene expression in brain cancer in vivo with 111In-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology. (15471847)
2004
38
Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung. (15131050)
2004
39
Parental occupational exposure to pesticides and childhood brain cancer. (12777362)
2003
40
Health related quality of life assessment methodology and reported outcomes in randomised controlled trials of primary brain cancer patients. (12204663)
2002
41
A human IAP-family gene, apollon, expressed in human brain cancer cells. (10544019)
1999
42
Complete response of a large brain metastasis of renal cell cancer to interferon-alpha: case report. (10086493)
1999
43
Diet and brain cancer in adults: a case-control study in northeast China. (10077146)
1999
44
cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells. (9473672)
1998
45
Computer screens and brain cancer. (8867387)
1995
46
Brain cancer incidence, mortality and case survival: observations from two Australian cancer registries. (7989116)
1994
47
Brain cancer near Los Alamos? (1871598)
1991
48
An analysis of occupational risks for brain cancer. (2297060)
1990
49
Immunological enhancement of chemotherapy in advanced brain cancer. (1243998)
1975
50
Chemotherapy of brain cancer: experimental and clinical studies in localized hypothermic cerebral perfusion. (13845852)
1959

Genetic Variations for Brain Cancer

Expression for genes affiliated with Brain Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Brain Cancer

Search GEO for disease gene expression data for Brain Cancer.

Pathways for genes affiliated with Brain Cancer

Sources:
52QIAGEN, 30KEGG, 60Tocris Bioscience, 4Cell Signaling Technology, 53R&D Systems, 38NCBI BioSystems Database, 50PharmGKB
See all sources

Pathways related to Brain Cancer according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1PDGFRB, EGFR, VEGFB, BAX, INSR, IL13
2
Hide members
11.1PDGFRB, EGFR, VEGFB, BAX, INSR, IL13
3
Hide members
11.1PDGFRB, EGFR, VEGFB, BAX, INSR, IL13
4
Hide members
11.1PDGFRB, EGFR, VEGFB, BAX, INSR, IL13
5
Hide members
11.0IL13, INSR, BAX, EGFR, PDGFRB
6
Hide members
11.0PDGFRB, EGFR, VEGFB, BAX, IL13
7
Hide members
11.0PDGFRB, EGFR, VEGFB, BAX, INSR
8
Hide members
11.0PDGFRB, EGFR, VEGFB, NANOG, INSR
9
Hide members
10.9PDGFRB, ARHGAP1, EGFR, INSR
10
Hide members
10.9INSR, VEGFB, EGFR, PDGFRB
1110.9PDGFRB, EGFR, VEGFB, INSR
1210.9PDGFRB, EGFR, VEGFB, INSR
1310.9PDGFRB, EGFR, VEGFB, BAX
1410.8INSR, EGFR, PDGFRB
1510.8PDGFRB, EGFR, INSR
1610.8PDGFRB, EGFR, INSR
1710.8INSR, EGFR, PDGFRB
18
Hide members
10.8BAX, EGFR, PDGFRB

Compounds for genes affiliated with Brain Cancer

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 11DrugBank
See all sources

Compounds related to Brain Cancer according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1vegf4511.5IL13, INSR, BAX, VEGFB, EGFR, CT49
2ly2940024511.3PDGFRB, EGFR, BAX, INSR, IL13
3retinoic acid45 2412.3IL13, BAX, NEFL, EGFR, CT49, PDGFRB
4docetaxel45 50 60 1114.2PDGFRB, EGFR, PRDX4, BAX
5agar4511.2PDGFRB, CT49, EGFR, INSR
6h2o24511.2IL13, INSR, BAX, PRDX4, PDGFRB
7sb 20358045 6012.1EGFR, BAX, INSR, IL13
8flavopiridol45 1112.1BAX, EGFR, PDGFRB
9gefitinib45 50 1113.1PDGFRB, EGFR, INSR
10pki-1664511.0EGFR, PDGFRB
11zd64744511.0EGFR, PDGFRB
12n,n-dimethylsphingosine45 6012.0BAX, EGFR
13ag 10244510.9INSR, EGFR
14homoharringtonine45 1111.9BAX, KLF10
15gemcitabine45 50 1112.9PDGFRB, EGFR, BAX
16pd 98,0594510.9EGFR, BAX, INSR, IL13
17ursolic acid4510.9BAX, INSR
18ag-12964510.8EGFR, PDGFRB
19su54164510.7EGFR, PDGFRB
20capecitabine45 50 1112.7EGFR, PDGFRB
21wortmannin4510.6PDGFRB, BAX, INSR, IL13
22shikonin4510.6EGFR, BAX

GO Terms for genes affiliated with Brain Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Brain Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell migrationGO:03033510.9INSR, MIEN1, EGFR, PDGFRB
2positive regulation of protein kinase B signaling cascadeGO:05189710.8INSR, VEGFB, EGFR
3positive regulation of release of sequestered calcium ion into cytosolGO:05128110.7IL13, BAX
4regulation of peptidyl-tyrosine phosphorylationGO:05073010.6PDGFRB, EGFR
5positive regulation of ERK1 and ERK2 cascadeGO:07037410.5VEGFB, EGFR, PDGFRB

Molecular functions related to Brain Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:00471310.8INSR, EGFR, PDGFRB
2receptor signaling protein tyrosine kinase activityGO:00471610.4INSR, EGFR

Products for genes affiliated with Brain Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brain Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet