MCID: BRN028
MIFTS: 67

Brain Cancer malady

Cancer diseases, Neuronal diseases categories

Summaries for Brain Cancer

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Cancer of the brain is usually called a brain tumor. there are two main types. a primary brain tumor starts in the brain. a metastatic brain tumor starts somewhere else in the body and moves to the brain. brain tumors can be benign, with no cancer cells, or malignant, with cancer cells that grow quickly. brain tumors can cause many symptoms. some of the most common are headaches, usually worse in the morning nausea and vomiting changes in your ability to talk, hear, or see problems with balance or walking problems with thinking or memory muscle jerking or twitching numbness or tingling in arms or legs doctors diagnose brain tumors by doing a neurologic exam and tests including an mri, ct scan, and biopsy. people with brain tumors have several treatment options. the options are surgery, radiation therapy, and chemotherapy. many people get a combination of treatments. nih: national cancer institute

MalaCards: Brain Cancer, also known as adult brain tumor, is related to leukemia and meningioma. An important gene associated with Brain Cancer is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs carmustine and etoposide and the compounds vegf and ly294002 have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and lung, and related mouse phenotypes are cellular and reproductive system.

Wikipedia:63 A brain tumor or brain tumour, is an intracranial solid neoplasm, a tumor (defined as an abnormal growth... more...

Aliases & Classifications for Brain Cancer

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain cancer 8 10 44 33
adult brain tumor 8 44 60
primary malignant neoplasm of brain 8 60
neoplasm of unspecified nature of brain 8
malignant primary brain neoplasm 8
malignant primary brain tumors 44
malignant tumor of adult brain 8
adult malignant brain neoplasm 8
malignant primary brain tumor 8
malignant neoplasm of brain 60
malignant tumor of brain 8
malignant brain tumour 8
primary brain neoplasm 8
brain neoplasm, adult 8
brain tumor, primary 60
brain tumor primary 44
primary brain tumor 8
tumor of the brain 8
brain tumor, adult 42
bt - brain tumour 8
neoplasm of brain 8
brain neoplasms 60
brain neoplasm 8
brain tumors 44
brain ca 8


Related Diseases for Brain Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Brain Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.4PDGFRB, PRDX4, VEGFB, BAX
2meningioma30.4CT49, PDGFRB
3breast cancer30.2TP53AIP1, INSR, MIEN1, BAX, VEGFB, PRDX4
4malignant glioma30.1EGFR, PDGFRB, BAX, IL13, NEFL, INSR
5glioblastoma multiforme30.1IL13, CT49, PDGFRB, EGFR, BAX
6adenocarcinoma30.1INSR, BAX, PRDX4, PDGFRB, CT49, EGFR
7oligodendroglioma30.0EGFR, CT49, PDGFRB
8malignant mesothelioma29.9PDGFRB, CT49
9prostate cancer29.7VEGFB, INSR, BAX, CT49, PDGFRB, EGFR
10colorectal cancer29.7VEGFB, INSR, BAX, PDGFRB, CT49, EGFR
11astrocytoma29.7IL13, PDGFRB, CT49, EGFR
12pancreatic cancer29.7BAX, VEGFB, EGFR, KLF10
13medulloblastoma29.7CT49
14lung adenocarcinoma29.7VEGFB, BAX, EGFR, PDGFRB
15lung cancer29.7EGFR
16gliosarcoma10.3
17neuronitis10.3
18atypical teratoid rhabdoid tumor10.3
19brain glioma10.3
20brain stem neoplasm10.2
21brain meningioma10.2
22brain tumor, childhood10.2
23brain ependymoma10.2
24juvenile pilocytic astrocytoma10.1
25juvenile astrocytoma10.1
26brain disease10.1
27pseudotumor cerebri10.1
28li-fraumeni syndrome10.1
29hemangioblastoma10.1
30brain glioblastoma multiforme10.1
31intracranial aneurysm10.1
32pediatric ependymoma10.1
33ganglioglioma10.1
34childhood germ cell brain tumor10.1
35acute leukemia10.1
36aphasia10.1
37brain stem glioma10.1
38ependymoblastoma10.1
39papilledema10.1
40oligoastrocytoma10.1
41brain tumor-polyposis syndrome 210.1
42neurofibromatosis10.0
43appendicitis10.0
44hepatitis b10.0
45hepatitis10.0
46liver disease10.0
47acoustic neuroma10.0
48neuroma10.0
49melanotic neuroectodermal tumor10.0
50oculocerebrorenal syndrome10.0

Graphical network of the top 20 diseases related to Brain Cancer:



Diseases related to brain cancer

Clinical Features for Brain Cancer

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Drugs & Therapeutics for Brain Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Brain Cancer

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Anatomical Context for Brain Cancer

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Sources:
32MalaCards
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MalaCards organs/tissues related to Brain Cancer:

32
Brain, Breast, Lung, Testes, Pineal, Pituitary, Endothelial, Testis, Prostate, Colon, Liver, Bone, Thyroid, Skin, Kidney, Salivary gland, Cervix, T cells, Spinal cord

Animal Models for Brain Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Brain Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.4PDGFRB, ARHGAP1, EGFR, PRDX4, BAX, NANOG
2MP:000538911.2IL13, PDGFRB, ARHGAP1, EGFR, PRDX4, VEGFB
3MP:000537910.6PDGFRB, CRYM, PRDX4, BAX

Publications for Brain Cancer

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Sources:
50PubMed
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Articles related to Brain Cancer:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
A case of gastric cancer manifesting as a solitary brain metastasis in the cerebellopontine angle that mimicked acoustic neuroma. (24400217)
2013
2
C1q-tumor necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells. (24014093)
2013
3
Unusual presentation of a rare cancer: histiocytic sarcoma in the brain 16 years after treatment for acute lymphoblastic leukemia. (22997353)
2013
4
Bridging science and clinical practice: how to use molecular markers when caring for a patient with brain cancer. (23714471)
2013
5
Involvement of tumor acidification in brain cancer pathophysiology. (24198789)
2013
6
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (23667531)
2013
7
OSU-03012 interacts with lapatinib to kill brain cancer cells. (22990204)
2012
8
Human brain cancer studied by resonance Raman spectroscopy. (23154776)
2012
9
Development of docetaxel-loaded vitamin E TPGS micelles: formulation optimization, effects on brain cancer cells and biodistribution in rats. (22329606)
2012
10
Preclinical evaluation of oncolytic I'I^(1)34.5 herpes simplex virus expressing interleukin-12 for therapy of breast cancer brain metastases. (23346408)
2012
11
Evaluation of health-related quality of life in Lithuanian brain tumor patients using the EORTC brain cancer module. (23455894)
2012
12
Relevance of PTEN loss in brain metastasis formation in breast cancer patients. (22429330)
2012
13
Brain natriuretic peptide levels in pediatric cancer patients with febrile neutropenia. (21413834)
2011
14
Nitrates in drinking water and the risk of death from brain cancer: does hardness in drinking water matter? (21541877)
2011
15
Expression of metastasis suppressor gene maspin is reduced in breast cancer brain metastases and correlates with the estrogen receptor status. (19909580)
2010
16
Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma. (20663133)
2010
17
Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells. (20554106)
2010
18
Occupational and environmental risk factors for brain cancer: a pilot case-control study in France. (19962851)
2010
19
Sniffing out cancer using the JPL electronic nose: a pilot study of a novel approach to detection and differentiation of brain cancer. (19362154)
2009
20
The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain. (19190132)
2009
21
Application of a global proteomic approach to archival precursor lesions: deleted in malignant brain tumors 1 and tissue transglutaminase 2 are upregulated in pancreatic cancer precursors. (18849643)
2008
22
Brain tumor stem cells: bringing order to the chaos of brain cancer. (18539973)
2008
23
Occupational electromagnetic fields and leukemia and brain cancer: an update to two meta-analyses. (18545095)
2008
24
Erosive pustular dermatosis of the scalp after gefitinib and radiotherapy for brain metastases secondary to lung cancer. (17983449)
2008
25
Battling brain cancer. (18634548)
2008
26
Brain metabolic changes associated with predispotion to onset of major depressive disorder and adjustment disorder in cancer patients--a preliminary PET study. (16684544)
2007
27
All in the family: using inherited cancer syndromes to understand de-regulated cell signaling in brain tumors. (17721931)
2007
28
Development of a three-dimensional multiscale agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer. (16949103)
2007
29
Gene selection for brain cancer classification. (17947170)
2006
30
EGFR mutations in patients with brain metastases from lung cancer: association with the efficacy of gefitinib. (16510849)
2006
31
Absence of adrenocorticotropin (ACTH) neurosecretory dysfunction but increased cortisol concentrations and production rates in ACTH-replete adult cancer survivors after cranial irradiation for nonpituitary brain tumors. (16105961)
2005
32
Zero efficacy with cesium chloride self-treatment for brain cancer. (15595349)
2004
33
Psychological outcomes in long-term survivors of childhood brain cancer: a report from the childhood cancer survivor study. (15020603)
2004
34
A case of brain metastasis associated with prostate cancer]. (15032014)
2004
35
Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia. (14559878)
2003
36
Null association between frequency of cured meat consumption and methylvaline and ethylvaline hemoglobin adduct levels: the N-nitroso brain cancer hypothesis. (11927506)
2002
37
Cellular telephones and brain cancer: current research. (11401770)
2001
38
Cell phones & brain cancer. No clear connection. (11192814)
2000
39
Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. (9950216)
1999
40
Metastatic spread and common symptoms. Part One: Introduction, bladder cancer, and brain cancer. (9866458)
1998
41
Primary brain cancer in adults and the use of common household appliances: a case-control study. (9128911)
1997
42
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. (9072974)
1997
43
Brain cancer, flying, and socioeconomic status: a nested case-control study of USAF aircrew. (8968480)
1996
44
Interpretation of secular increases in incidence rates for primary brain cancer in Connecticut adults, 1965-1988. (8719049)
1996
45
Family pesticide and childhood brain cancer. (8110021)
1994
46
Memoirs of an amnesiac--two years with brain cancer, or the outer space of living with brain tumors. (1815419)
1991
47
Human malignant astrocytoma xenografts migrate in rat brain: a model for central nervous system cancer research. (2651679)
1989
48
Paternal occupation and brain cancer in offspring: a mortality-based case-control study. (3189347)
1988
49
Brain cancer--Texas. (6431254)
1984
50
The optimun schedule for palliative radiotherapy for metastatic brain cancer. (66225)
1977

Genetic Variations for Brain Cancer

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Expression for genes affiliated with Brain Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Cancer

Search GEO for disease gene expression data for Brain Cancer.

Pathways for genes affiliated with Brain Cancer

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Sources:
51QIAGEN, 29KEGG, 59Tocris Bioscience, 4Cell Signaling Technology, 52R&D Systems, 37NCBI BioSystems Database, 49PharmGKB
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Pathways related to Brain Cancer according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.1PDGFRB, EGFR, VEGFB, BAX, INSR, IL13
2
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11.1PDGFRB, EGFR, VEGFB, BAX, INSR, IL13
3
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11.1PDGFRB, EGFR, VEGFB, BAX, INSR, IL13
4
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11.1PDGFRB, EGFR, VEGFB, BAX, INSR, IL13
5
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11.0IL13, INSR, BAX, EGFR, PDGFRB
6
Hide members
11.0PDGFRB, EGFR, VEGFB, BAX, IL13
7
Hide members
11.0PDGFRB, EGFR, VEGFB, BAX, INSR
8
Hide members
11.0PDGFRB, EGFR, VEGFB, NANOG, INSR
9
Hide members
10.9PDGFRB, ARHGAP1, EGFR, INSR
10
Hide members
10.9INSR, VEGFB, EGFR, PDGFRB
1110.9PDGFRB, EGFR, VEGFB, INSR
1210.9PDGFRB, EGFR, VEGFB, INSR
1310.9PDGFRB, EGFR, VEGFB, BAX
1410.8INSR, EGFR, PDGFRB
1510.8PDGFRB, EGFR, INSR
1610.8PDGFRB, EGFR, INSR
1710.8INSR, EGFR, PDGFRB
18
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10.8BAX, EGFR, PDGFRB

Compounds for genes affiliated with Brain Cancer

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
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Compounds related to Brain Cancer according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1vegf4411.5IL13, INSR, BAX, VEGFB, EGFR, CT49
2ly2940024411.3PDGFRB, EGFR, BAX, INSR, IL13
3retinoic acid44 2412.3IL13, BAX, NEFL, EGFR, CT49, PDGFRB
4docetaxel44 49 59 1114.2PDGFRB, EGFR, PRDX4, BAX
5agar4411.2PDGFRB, CT49, EGFR, INSR
6h2o24411.2IL13, INSR, BAX, PRDX4, PDGFRB
7sb 20358044 5912.1EGFR, BAX, INSR, IL13
8flavopiridol44 1112.1BAX, EGFR, PDGFRB
9gefitinib44 49 1113.1PDGFRB, EGFR, INSR
10pki-1664411.0EGFR, PDGFRB
11zd64744411.0EGFR, PDGFRB
12n,n-dimethylsphingosine44 5912.0BAX, EGFR
13ag 10244410.9INSR, EGFR
14homoharringtonine44 1111.9BAX, KLF10
15gemcitabine44 49 1112.9PDGFRB, EGFR, BAX
16pd 98,0594410.9EGFR, BAX, INSR, IL13
17ursolic acid4410.9BAX, INSR
18ag-12964410.8EGFR, PDGFRB
19su54164410.7EGFR, PDGFRB
20capecitabine44 49 1112.7EGFR, PDGFRB
21wortmannin4410.6PDGFRB, BAX, INSR, IL13
22shikonin4410.6EGFR, BAX

GO Terms for genes affiliated with Brain Cancer

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16Gene Ontology
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Biological processes related to Brain Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell migrationGO:03033510.9INSR, MIEN1, EGFR, PDGFRB
2positive regulation of protein kinase B signaling cascadeGO:05189710.8INSR, VEGFB, EGFR
3positive regulation of release of sequestered calcium ion into cytosolGO:05128110.7IL13, BAX
4regulation of peptidyl-tyrosine phosphorylationGO:05073010.6PDGFRB, EGFR
5positive regulation of ERK1 and ERK2 cascadeGO:07037410.5VEGFB, EGFR, PDGFRB

Molecular functions related to Brain Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:00471310.8INSR, EGFR, PDGFRB
2receptor signaling protein tyrosine kinase activityGO:00471610.4INSR, EGFR

Products for genes affiliated with Brain Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brain Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet