MCID: BRN028
MIFTS: 62

Brain Cancer malady

Rare diseases, Cancer diseases, Neuronal diseases categories
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Summaries for Brain Cancer

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Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Cancer of the brain is usually called a brain tumor. there are two main types. a primary brain tumor starts in the brain. a metastatic brain tumor starts somewhere else in the body and moves to the brain. brain tumors can be benign, with no cancer cells, or malignant, with cancer cells that grow quickly. brain tumors can cause many symptoms. some of the most common are headaches, usually worse in the morning nausea and vomiting changes in your ability to talk, hear, or see problems with balance or walking problems with thinking or memory muscle jerking or twitching numbness or tingling in arms or legs doctors diagnose brain tumors by doing a neurologic exam and tests including an mri, ct scan, and biopsy. people with brain tumors have several treatment options. the options are surgery, radiation therapy, and chemotherapy. many people get a combination of treatments. nih: national cancer institute

MalaCards: Brain Cancer, also known as adult brain tumor, is related to gliosarcoma and glioblastoma multiforme. An important gene associated with Brain Cancer is IL13 (interleukin 13), and among its related pathways are AHR Pathway and Akt Signaling Pathway. The drugs carmustine and etoposide and the compounds pki-166 and zd6474 have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast.

Wikipedia:65 A brain tumor or intracranial neoplasm occurs when abnormal cells form within the brain. There are two... more...

Aliases & Classifications for Brain Cancer

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain cancer 8 10 45 34
adult brain tumor 8 45 62
primary malignant neoplasm of brain 8 62
neoplasm of unspecified nature of brain 8
malignant primary brain neoplasm 8
adult malignant brain neoplasm 8
malignant tumor of adult brain 8
malignant primary brain tumors 45
malignant primary brain tumor 8
malignant neoplasm of brain 62
malignant tumor of brain 8
malignant brain tumour 8
primary brain neoplasm 8
brain neoplasm, adult 8
brain tumor, primary 62
primary brain tumor 8
brain tumor primary 45
tumor of the brain 8
brain tumor, adult 43
neoplasm of brain 8
bt - brain tumour 8
brain neoplasms 62
brain neoplasm 8
brain tumors 45
brain ca 8


Related Diseases for Brain Cancer

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Brain Cancer:



Diseases related to brain cancer

Symptoms for Brain Cancer

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Drugs & Therapeutics for Brain Cancer

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Brain Cancer

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Anatomical Context for Brain Cancer

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Sources:
33MalaCards
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MalaCards organs/tissues related to Brain Cancer:

33
Brain, Testes, Breast, Liver, Thyroid, Salivary gland, Prostate, T cells

Animal Models for Brain Cancer or affiliated genes

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Publications for Brain Cancer

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Sources:
52PubMed
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Articles related to Brain Cancer:

(show top 50)    (show all 358)
idTitleAuthorsYear
1
Protein-protein interaction network analysis and gene set enrichment analysis in epilepsy patients with brain cancer. (24239228)
2014
2
DRR regulates AKT activation to drive brain cancer invasion. (24141773)
2013
3
C1q-tumor necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells. (24014093)
2013
4
Update on bevacizumab and other angiogenesis inhibitors for brain cancer. (23668489)
2013
5
Possible role of Toxoplasma gondii in brain cancer through modulation of host microRNAs. (23391314)
2013
6
Brain cancer in workers employed at a specialty chemical research facility. (23697694)
2013
7
Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy. (24025251)
2013
8
Brain cancer in 2012: Molecular characterization leads the way. (23296110)
2013
9
The vitamin D receptor (VDR) gene polymorphisms in Turkish brain cancer patients. (23691496)
2013
10
Reduced Risk of Brain Cancer Mortality from Walking and Running. (24091993)
2013
11
Bridging science and clinical practice: how to use molecular markers when caring for a patient with brain cancer. (23714471)
2013
12
Sulfasalazine for brain cancer fits. (22404218)
2012
13
Search for a diagnostic/prognostic biomarker for the brain cancer glioblastoma multiforme by 2D-DIGE-MS technique. (22547198)
2012
14
Synthesis and antiproliferative activity of ammonium and imidazolium ionic liquids against T98G brain cancer cells. (23174892)
2012
15
OSU-03012 interacts with lapatinib to kill brain cancer cells. (22990204)
2012
16
Synthesis and characterization of pH-dependent glycol chitosan and dextran sulfate nanoparticles for effective brain cancer treatment. (21782844)
2011
17
Compact point-detection fluorescence spectroscopy system for quantifying intrinsic fluorescence redox ratio in brain cancer diagnostics. (21456877)
2011
18
Comments on de Vocht et al. "Time trends (1998-2007) in brain cancer incidence rates in relation to mobile phone use in England". (21611956)
2011
19
The interphone study: brain cancer and beyond. (21225893)
2011
20
Synergistic induction of apoptosis in brain cancer cells by targeted codelivery of siRNA and anticancer drugs. (21793576)
2011
21
Corticosteroids in brain cancer patients: benefits and pitfalls. (21666852)
2011
22
Bioprocessing of human glioblastoma brain cancer tissue. (20021271)
2010
23
Modulation of carbonic anhydrase 9 (CA9) in human brain cancer. (20819065)
2010
24
Sniffing out cancer using the JPL electronic nose: a pilot study of a novel approach to detection and differentiation of brain cancer. (19362154)
2009
25
A high-performance nanobio photocatalyst for targeted brain cancer therapy. (19640002)
2009
26
Dietary zinc intake and brain cancer in adults: a case-control study. (17908366)
2008
27
Trends in the brain cancer incidence in India. (18712971)
2008
28
Biomarker discovery: a proteomic approach for brain cancer profiling. (17233837)
2007
29
Brain cancer stem-like cells. (16632342)
2006
30
Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. (16709014)
2006
31
Occupational risk factors for brain cancer in Canada. (16010197)
2005
32
Stem cells and brain cancer. (15925587)
2005
33
Large variations seen in treatment of adults with brain cancer. (15812070)
2005
34
The brain-cancer puzzle. (15039039)
2004
35
Zero efficacy with cesium chloride self-treatment for brain cancer. (15595349)
2004
36
Vinyl chloride and liver and brain cancer at a polymer production plant in Louisville, Kentucky. (12762078)
2003
37
Brain cancer in a residential area bordering on an oil refinery. (12566954)
2003
38
Parental occupational exposure to pesticides and childhood brain cancer. (12777362)
2003
39
SV40 in human brain cancers and non-Hodgkin's lymphoma. (12910253)
2003
40
Cellular telephones and brain cancer: current research. (11401770)
2001
41
Handheld cellular telephones and brain cancer risk. (11308389)
2001
42
Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease. (10813724)
2000
43
A human IAP-family gene, apollon, expressed in human brain cancer cells. (10544019)
1999
44
Pesticide prioritization for a brain cancer case-control study. (9339226)
1997
45
The use of significant others as proxy raters of the quality of life of patients with brain cancer. (9140337)
1997
46
Aspartame and brain cancer. (9024408)
1997
47
Brain cancer and leukemia and exposure to power-frequency (50- to 60-Hz) electric and magnetic fields. (9494788)
1997
48
Cohort and nested case-control studies of hematopoietic cancers and brain cancer among electric utility workers. (8452898)
1993
49
Association of brain cancer with dental X-rays and occupation in Missouri. (1646072)
1991
50
A New York neurosurgeon turns to multi-modality therapy to treat brain cancer. (2342123)
1990

Variations for Brain Cancer

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Expression for genes affiliated with Brain Cancer

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Cancer

Search GEO for disease gene expression data for Brain Cancer.

Pathways for genes affiliated with Brain Cancer

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Sources:
50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 54R&D Systems, 5Cell Signaling Technology, 51PharmGKB, 61Tocris Bioscience, 60Thomson Reuters, 30KEGG
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Pathways related to Brain Cancer according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
AhR pathway38
10.0EGFR, BAX
29.8EGFR, PDGFRB, INSR
39.8EGFR, PDGFRB, INSR
49.8EGFR, PDGFRB, INSR
59.8INSR, PDGFRB, EGFR
69.8INSR, PDGFRB, EGFR
7
Show member pathways
9.8EGFR, BAX, PDGFRB
8
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.8EGFR, BAX, PDGFRB
9
Show member pathways
9.5TUBB8, PDGFRB, EGFR
10
Show member pathways
9.4INSR, IL13, PDGFRB, BAX, EGFR
11
Show member pathways
9.4INSR, IL13, PDGFRB, BAX, EGFR
12
Show member pathways
9.4EGFR, BAX, PDGFRB, IL13, INSR
13
Show member pathways
9.4INSR, IL13, PDGFRB, BAX, EGFR
14
Show member pathways
9.4INSR, IL13, PDGFRB, BAX, EGFR

Compounds for genes affiliated with Brain Cancer

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Sources:
45Novoseek, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 29IUPHAR, 3BitterDB, 24HMDB
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Compounds related to Brain Cancer according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1pki-1664510.4EGFR, PDGFRB
2zd64744510.4EGFR, PDGFRB
3ag 10244510.4INSR, EGFR
4n,n-dimethylsphingosine45 6111.4BAX, EGFR
5ursolic acid4510.4BAX, INSR
6ag-12964510.3EGFR, PDGFRB
7su54164510.3EGFR, PDGFRB
8shikonin4510.3BAX, EGFR
9capecitabine45 51 1112.3PDGFRB, EGFR
10sunitinib45 51 1112.2EGFR, PDGFRB
11flavopiridol45 1111.2PDGFRB, BAX, EGFR
12gefitinib45 51 1112.2INSR, PDGFRB, EGFR
13manumycin4510.2INSR, EGFR
14gemcitabine45 51 1112.2EGFR, BAX, PDGFRB
15regorafenib51 1111.2EGFR, PDGFRB
16docetaxel45 51 61 1113.1EGFR, BAX, PDGFRB
17egcg4510.1PDGFRB, BAX, EGFR
18sb 20358045 6111.0INSR, IL13, BAX, EGFR
19wortmannin4510.0INSR, IL13, PDGFRB, BAX
20leflunomide45 51 1112.0IL13, PDGFRB
21pd 98,0594510.0INSR, IL13, BAX, EGFR
22genistein45 29 61 3 24 1114.9INSR, PDGFRB, BAX, EGFR
235fluorouracil459.8PDGFRB, BAX, EGFR
24ly294002459.8EGFR, BAX, PDGFRB, IL13, INSR
25dasatinib45 51 1111.7PDGFRB, EGFR
26vegf459.7INSR, IL13, PDGFRB, BAX, EGFR
27phosphatidylinositol459.7INSR, IL13, PDGFRB, BAX, EGFR
28cycloheximide459.7INSR, IL13, BAX, EGFR
29h2o2459.6BAX, PDGFRB, IL13, INSR
30estrogen459.6INSR, IL13, PDGFRB, BAX, EGFR

GO Terms for genes affiliated with Brain Cancer

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16Gene Ontology
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Biological processes related to Brain Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of peptidyl-tyrosine phosphorylationGO:05073010.2EGFR, PDGFRB
2positive regulation of release of sequestered calcium ion into cytosolGO:05128110.1IL13, BAX
3positive regulation of nitric oxide biosynthetic processGO:04542910.0EGFR, INSR
4positive regulation of smooth muscle cell proliferationGO:04866110.0IL13, PDGFRB, EGFR
5peptidyl-tyrosine phosphorylationGO:01810810.0EGFR, PDGFRB, INSR
6positive regulation of mitosisGO:0458409.8PDGFRB, INSR
7protein autophosphorylationGO:0467779.7INSR, PDGFRB, EGFR
8positive regulation of cell migrationGO:0303359.6EGFR, PDGFRB, MIEN1, INSR
9negative regulation of apoptotic processGO:0430669.4EGFR, PDGFRB, MIEN1, CBX4

Molecular functions related to Brain Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:00471610.0EGFR, INSR
2phosphatidylinositol 3-kinase bindingGO:0435489.8INSR, PDGFRB
3protein tyrosine kinase activityGO:0047139.7EGFR, PDGFRB, INSR
4protein bindingGO:0055157.4IRF2BP1, CBX4, IL13, MAGEC2, PDGFRB, BAG2

Products for genes affiliated with Brain Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brain Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet