MCID: BRN028
MIFTS: 56

Brain Cancer malady

Rare diseases, Cancer diseases, Neuronal diseases categories

Aliases & Classifications for Brain Cancer

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Aliases & Descriptions for Brain Cancer:

Name: Brain Cancer 8 10 44
Adult Brain Tumor 8 44 61
Primary Malignant Neoplasm of Brain 8 61
Brain Tumors 44 32
Neoplasm of Unspecified Nature of Brain 8
Malignant Primary Brain Neoplasm 8
Malignant Primary Brain Tumors 44
Adult Malignant Brain Neoplasm 8
Malignant Adult Brain Neoplasm 61
Malignant Tumor of Adult Brain 8
Malignant Primary Brain Tumor 8
Malignant Neoplasm of Brain 61
Malignant Tumor of Brain 8
 
Malignant Brain Tumour 8
Primary Brain Neoplasm 8
Brain Neoplasm, Adult 8
Brain Tumor, Primary 61
Brain Tumor Primary 44
Primary Brain Tumor 8
Brain Tumor, Adult 42
Tumor of the Brain 8
Bt - Brain Tumour 8
Neoplasm of Brain 8
Brain Neoplasms 61
Brain Neoplasm 8


Classifications:



Summaries for Brain Cancer

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MedlinePlus:32 A brain tumor is a growth of abnormal cells in the tissues of the brain. brain tumors can be benign, with no cancer cells, or malignant, with cancer cells that grow quickly. some are primary brain tumors, which start in the brain. others are metastatic, and they start somewhere else in the body and move to the brain. brain tumors can cause many symptoms. some of the most common are headaches, often in the morning nausea and vomiting changes in your ability to talk, hear, or see problems with balance or walking problems with thinking or memory feeling weak or sleepy changes in your mood or behavior seizures doctors diagnose brain tumors by doing a neurologic exam and tests including an mri, ct scan, and biopsy. treatment options include watchful waiting, surgery, radiation therapy, chemotherapy, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. many people get a combination of treatments. nih: national cancer institute

MalaCards based summary: Brain Cancer, also known as adult brain tumor, is related to gliosarcoma and glioblastoma. An important gene associated with Brain Cancer is IL13 (interleukin 13), and among its related pathways are AHR Pathway and Akt Signaling Pathway. The drugs carmustine and etoposide and the compounds pki-166 and zd6474 have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast.

Disease Ontology:8 A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain.

Wikipedia:64 A brain tumor or intracranial neoplasm occurs when abnormal cells form within the brain. There are two... more...

Related Diseases for Brain Cancer

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Graphical network of the top 20 diseases related to Brain Cancer:



Diseases related to brain cancer

Symptoms for Brain Cancer

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Drugs & Therapeutics for Brain Cancer

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FDA approved drugs:

id Drug Name Active Ingredient(s)13 Pharmaceutical Company Approval Date
1
Gliadel Wafer13 38 CARMUSTINE Rhone-Poulenc Rorer, Guilford Pharmaceuticals Approved February 1997
FDA Label: Gliadel Wafer
Malady that Drug Treats: brain cancer
Indications and Usage:13 GLIADELWaferisanalkylatingdrugindicatedforthetreatmentof:; newly-diagnosedhigh-grade-malignantgliomaasanadjuncttosurgeryand; radiation(1)and; recurrentglioblastomamultiformeasanadjuncttosurgery(1)
DrugBank Targets:11 1. Glutathione reductase, mitochondrial; 2. DNA; 3. RNA
Mechanism of Action:13 
Target: DNA and RNA
Action: alkylating agent
FDA: The activity of GLIADEL Wafer is due to release of cytotoxic concentrations of carmustine, a; DNA and RNA alkylating agent, into the tumor resection cavity. On exposure to the aqueous; environment of the resection cavity, the anhydride bonds in the copolymer are hydrolyzed,; releasing carmustine, carboxyphenoxypropane, and sebacic acid into the surrounding brain; tissue.
2
Temodar13 38 TEMOZOLOMIDE Schering-Plough Approved August 1999
FDA Label: Temodar
Malady that Drug Treats: refractory anaplastic astrocytoma
Indications and Usage:13 TEMODAR is an alkylating drug indicated for the treatment of adult; patients with:; Newly diagnosed glioblastoma multiforme (GBM) concomitantly; with radiotherapy and then as maintenance treatment. (1.1); Refractory anaplastic astrocytoma patients who have experienced; disease progression on a drug regimen containing nitrosourea; and procarbazine. (1.2)
DrugBank Targets:11 1. DNA
Mechanism of Action:13 
Target: DNA
Action: alkylizer
FDA: Temozolomide is not directly active but undergoes rapid nonenzymatic conversion at physiologic pH to the reactive compound; 5-(3-methyltriazen-1-yl)-imidazole-4-carboxamide (MTIC). The cytotoxicity of MTIC is thought to be primarily due to alkylation of; DNA. Alkylation (methylation) occurs mainly at the O6 and N7 positions of guanine. ;

Drug clinical trials:

Search ClinicalTrials for Brain Cancer

Search NIH Clinical Center for Brain Cancer

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Brain Cancer

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Anatomical Context for Brain Cancer

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MalaCards organs/tissues related to Brain Cancer:

31
Brain, Testes, Breast, Liver, Lung, Thyroid, Salivary gland, Prostate, T cells

Animal Models for Brain Cancer or affiliated genes

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Publications for Brain Cancer

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Articles related to Brain Cancer:

(show top 50)    (show all 390)
idTitleAuthorsYear
1
Cytokines Play a Key Role in Communication between Mesenchymal Stem Cells and Brain Cancer Cells. (25642990)
2015
2
Protein-protein interaction network analysis and gene set enrichment analysis in epilepsy patients with brain cancer. (24239228)
2014
3
Combined Magnetic Nanoparticle-based MicroRNA and Hyperthermia Therapy to Enhance Apoptosis in Brain Cancer Cells. (24947843)
2014
4
Screening for brain cancer: why (not). (25173448)
2014
5
Brain cancer mortality in an agricultural and a metropolitan region of Rio de Janeiro, Brazil: a population-based, age-period-cohort study, 1996-2010. (24884498)
2014
6
Injecting hope into brain cancer treatment: is immunotherapy the way forward? (25054897)
2014
7
C1q-tumor necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells. (24014093)
2013
8
Update on bevacizumab and other angiogenesis inhibitors for brain cancer. (23668489)
2013
9
Possible role of Toxoplasma gondii in brain cancer through modulation of host microRNAs. (23391314)
2013
10
Brain cancer in workers employed at a specialty chemical research facility. (23697694)
2013
11
Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy. (24025251)
2013
12
Brain cancer in 2012: Molecular characterization leads the way. (23296110)
2013
13
The vitamin D receptor (VDR) gene polymorphisms in Turkish brain cancer patients. (23691496)
2013
14
Reduced Risk of Brain Cancer Mortality from Walking and Running. (24091993)
2013
15
Bridging science and clinical practice: how to use molecular markers when caring for a patient with brain cancer. (23714471)
2013
16
Sulfasalazine for brain cancer fits. (22404218)
2012
17
Search for a diagnostic/prognostic biomarker for the brain cancer glioblastoma multiforme by 2D-DIGE-MS technique. (22547198)
2012
18
Synthesis and antiproliferative activity of ammonium and imidazolium ionic liquids against T98G brain cancer cells. (23174892)
2012
19
OSU-03012 interacts with lapatinib to kill brain cancer cells. (22990204)
2012
20
Synthesis and characterization of pH-dependent glycol chitosan and dextran sulfate nanoparticles for effective brain cancer treatment. (21782844)
2011
21
Compact point-detection fluorescence spectroscopy system for quantifying intrinsic fluorescence redox ratio in brain cancer diagnostics. (21456877)
2011
22
Comments on de Vocht et al. "Time trends (1998-2007) in brain cancer incidence rates in relation to mobile phone use in England". (21611956)
2011
23
The interphone study: brain cancer and beyond. (21225893)
2011
24
Synergistic induction of apoptosis in brain cancer cells by targeted codelivery of siRNA and anticancer drugs. (21793576)
2011
25
Corticosteroids in brain cancer patients: benefits and pitfalls. (21666852)
2011
26
Bioprocessing of human glioblastoma brain cancer tissue. (20021271)
2010
27
Sniffing out cancer using the JPL electronic nose: a pilot study of a novel approach to detection and differentiation of brain cancer. (19362154)
2009
28
A high-performance nanobio photocatalyst for targeted brain cancer therapy. (19640002)
2009
29
Dietary zinc intake and brain cancer in adults: a case-control study. (17908366)
2008
30
Trends in the brain cancer incidence in India. (18712971)
2008
31
Biomarker discovery: a proteomic approach for brain cancer profiling. (17233837)
2007
32
Brain cancer stem-like cells. (16632342)
2006
33
Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. (16709014)
2006
34
Occupational risk factors for brain cancer in Canada. (16010197)
2005
35
Stem cells and brain cancer. (15925587)
2005
36
The brain-cancer puzzle. (15039039)
2004
37
Zero efficacy with cesium chloride self-treatment for brain cancer. (15595349)
2004
38
Vinyl chloride and liver and brain cancer at a polymer production plant in Louisville, Kentucky. (12762078)
2003
39
Brain cancer in a residential area bordering on an oil refinery. (12566954)
2003
40
Parental occupational exposure to pesticides and childhood brain cancer. (12777362)
2003
41
SV40 in human brain cancers and non-Hodgkin's lymphoma. (12910253)
2003
42
Cellular telephones and brain cancer: current research. (11401770)
2001
43
Handheld cellular telephones and brain cancer risk. (11308389)
2001
44
Long term survivors of childhood brain cancer have an increased risk for cardiovascular disease. (10813724)
2000
45
A human IAP-family gene, apollon, expressed in human brain cancer cells. (10544019)
1999
46
Pesticide prioritization for a brain cancer case-control study. (9339226)
1997
47
The use of significant others as proxy raters of the quality of life of patients with brain cancer. (9140337)
1997
48
Aspartame and brain cancer. (9024408)
1997
49
Cohort and nested case-control studies of hematopoietic cancers and brain cancer among electric utility workers. (8452898)
1993
50
Association of brain cancer with dental X-rays and occupation in Missouri. (1646072)
1991

Variations for Brain Cancer

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Cosmic variations for Brain Cancer:

6
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
128750IDH1central nervous system,brain,other,neoplasm3
228749IDH1central nervous system,brain,other,neoplasm3
328746IDH1central nervous system,brain,other,neoplasm3
428747IDH1central nervous system,brain,other,neoplasm3
528748IDH1central nervous system,brain,other,neoplasm3

Expression for genes affiliated with Brain Cancer

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Search GEO for disease gene expression data for Brain Cancer.

Pathways for genes affiliated with Brain Cancer

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Pathways related to Brain Cancer according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
AhR pathway36
10.0EGFR, BAX
29.8EGFR, PDGFRB, INSR
39.8EGFR, PDGFRB, INSR
49.8EGFR, PDGFRB, INSR
59.8INSR, PDGFRB, EGFR
69.8INSR, PDGFRB, EGFR
7
Show member pathways
9.8EGFR, BAX, PDGFRB
8
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
9.8EGFR, BAX, PDGFRB
9
Show member pathways
9.5TUBB8, PDGFRB, EGFR
10
Show member pathways
9.4INSR, IL13, PDGFRB, BAX, EGFR
11
Show member pathways
9.4INSR, IL13, PDGFRB, BAX, EGFR
12
Show member pathways
9.4EGFR, BAX, PDGFRB, IL13, INSR
13
Show member pathways
9.4INSR, IL13, PDGFRB, BAX, EGFR
14
Show member pathways
9.4INSR, IL13, PDGFRB, BAX, EGFR

Compounds for genes affiliated with Brain Cancer

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Compounds related to Brain Cancer according to GeneCards Suite gene sharing:

(show all 30)
idCompoundScoreTop Affiliating Genes
1pki-1664410.4PDGFRB, EGFR
2zd64744410.4PDGFRB, EGFR
3ag 10244410.4EGFR, INSR
4n,n-dimethylsphingosine44 6011.4EGFR, BAX
5ursolic acid4410.4INSR, BAX
6ag-12964410.3EGFR, PDGFRB
7su54164410.3EGFR, PDGFRB
8shikonin4410.3BAX, EGFR
9capecitabine44 50 1112.3PDGFRB, EGFR
10sunitinib44 50 1112.2EGFR, PDGFRB
11flavopiridol44 1111.2EGFR, BAX, PDGFRB
12gefitinib44 50 1112.2EGFR, INSR, PDGFRB
13manumycin4410.2EGFR, INSR
14gemcitabine44 50 1112.2PDGFRB, BAX, EGFR
15regorafenib50 1111.2PDGFRB, EGFR
16docetaxel44 50 60 1113.1EGFR, BAX, PDGFRB
17egcg4410.1PDGFRB, BAX, EGFR
18sb 20358044 6011.0EGFR, BAX, IL13, INSR
19wortmannin4410.0PDGFRB, INSR, BAX, IL13
20leflunomide44 50 1112.0IL13, PDGFRB
21pd 98,0594410.0IL13, BAX, EGFR, INSR
22genistein44 28 60 1 24 1114.9INSR, PDGFRB, EGFR, BAX
235fluorouracil449.8BAX, PDGFRB, EGFR
24ly294002449.8EGFR, INSR, IL13, PDGFRB, BAX
25dasatinib44 50 1111.7PDGFRB, EGFR
26vegf449.7EGFR, PDGFRB, BAX, IL13, INSR
27phosphatidylinositol449.7EGFR, PDGFRB, INSR, IL13, BAX
28cycloheximide449.7IL13, BAX, EGFR, INSR
29h2o2449.6BAX, IL13, INSR, PDGFRB
30estrogen449.6IL13, PDGFRB, BAX, EGFR, INSR

GO Terms for genes affiliated with Brain Cancer

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Biological processes related to Brain Cancer according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of peptidyl-tyrosine phosphorylationGO:005073010.2EGFR, PDGFRB
2positive regulation of release of sequestered calcium ion into cytosolGO:005128110.1IL13, BAX
3positive regulation of nitric oxide biosynthetic processGO:004542910.0EGFR, INSR
4positive regulation of smooth muscle cell proliferationGO:004866110.0IL13, PDGFRB, EGFR
5peptidyl-tyrosine phosphorylationGO:001810810.0EGFR, PDGFRB, INSR
6positive regulation of mitosisGO:00458409.8PDGFRB, INSR
7protein autophosphorylationGO:00467779.7INSR, PDGFRB, EGFR
8positive regulation of cell migrationGO:00303359.6EGFR, PDGFRB, MIEN1, INSR
9negative regulation of apoptotic processGO:00430669.4EGFR, PDGFRB, MIEN1, CBX4

Molecular functions related to Brain Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:000471610.0EGFR, INSR
2phosphatidylinositol 3-kinase bindingGO:00435489.8INSR, PDGFRB
3protein tyrosine kinase activityGO:00047139.7EGFR, PDGFRB, INSR
4protein bindingGO:00055157.4IRF2BP1, CBX4, IL13, MAGEC2, PDGFRB, BAG2

Sources for Brain Cancer

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet