MCID: BRN028
MIFTS: 67

Brain Cancer malady

Cancer diseases, Neuronal diseases categories

Summaries for Brain Cancer

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Cancer of the brain is usually called a brain tumor. there are two main types. a primary brain tumor starts in the brain. a metastatic brain tumor starts somewhere else in the body and moves to the brain. brain tumors can be benign, with no cancer cells, or malignant, with cancer cells that grow quickly. brain tumors can cause many symptoms. some of the most common are headaches, usually worse in the morning nausea and vomiting changes in your ability to talk, hear, or see problems with balance or walking problems with thinking or memory muscle jerking or twitching numbness or tingling in arms or legs doctors diagnose brain tumors by doing a neurologic exam and tests including an mri, ct scan, and biopsy. people with brain tumors have several treatment options. the options are surgery, radiation therapy, and chemotherapy. many people get a combination of treatments. nih: national cancer institute

MalaCards: Brain Cancer, also known as adult brain tumor, is related to leukemia and meningioma. An important gene associated with Brain Cancer is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are PEDF Induced Signaling and Rho Family GTPases. The drugs carmustine and etoposide and the compounds vegf and ly294002 have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and lung, and related mouse phenotypes are cellular and reproductive system.

Wikipedia:63 A brain tumor or brain tumour, is an intracranial solid neoplasm, a tumor (defined as an abnormal growth... more...

Aliases & Classifications for Brain Cancer

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain cancer 8 10 44 33
adult brain tumor 8 44 60
primary malignant neoplasm of brain 8 60
neoplasm of unspecified nature of brain 8
malignant primary brain neoplasm 8
malignant primary brain tumors 44
malignant tumor of adult brain 8
adult malignant brain neoplasm 8
malignant primary brain tumor 8
malignant neoplasm of brain 60
malignant tumor of brain 8
malignant brain tumour 8
primary brain neoplasm 8
brain neoplasm, adult 8
brain tumor, primary 60
brain tumor primary 44
primary brain tumor 8
tumor of the brain 8
brain tumor, adult 42
bt - brain tumour 8
neoplasm of brain 8
brain neoplasms 60
brain neoplasm 8
brain tumors 44
brain ca 8


Related Diseases for Brain Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Brain Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.4PDGFRB, PRDX4, VEGFB, BAX
2meningioma30.4CT49, PDGFRB
3breast cancer30.2TP53AIP1, INSR, MIEN1, BAX, VEGFB, PRDX4
4malignant glioma30.1EGFR, PDGFRB, BAX, IL13, NEFL, INSR
5glioblastoma multiforme30.1IL13, CT49, PDGFRB, EGFR, BAX
6adenocarcinoma30.1INSR, BAX, PRDX4, PDGFRB, CT49, EGFR
7oligodendroglioma30.0EGFR, CT49, PDGFRB
8malignant mesothelioma29.9PDGFRB, CT49
9prostate cancer29.7VEGFB, INSR, BAX, CT49, PDGFRB, EGFR
10colorectal cancer29.7VEGFB, INSR, BAX, PDGFRB, CT49, EGFR
11astrocytoma29.7IL13, PDGFRB, CT49, EGFR
12pancreatic cancer29.7BAX, VEGFB, EGFR, KLF10
13medulloblastoma29.7CT49
14lung adenocarcinoma29.7VEGFB, BAX, EGFR, PDGFRB
15lung cancer29.7EGFR
16gliosarcoma10.3
17neuronitis10.3
18atypical teratoid rhabdoid tumor10.3
19brain glioma10.3
20brain stem neoplasm10.2
21brain meningioma10.2
22brain tumor, childhood10.2
23brain ependymoma10.2
24juvenile pilocytic astrocytoma10.1
25juvenile astrocytoma10.1
26brain disease10.1
27pseudotumor cerebri10.1
28li-fraumeni syndrome10.1
29hemangioblastoma10.1
30brain glioblastoma multiforme10.1
31intracranial aneurysm10.1
32pediatric ependymoma10.1
33ganglioglioma10.1
34childhood germ cell brain tumor10.1
35acute leukemia10.1
36aphasia10.1
37brain stem glioma10.1
38ependymoblastoma10.1
39papilledema10.1
40oligoastrocytoma10.1
41brain tumor-polyposis syndrome 210.1
42neurofibromatosis10.0
43appendicitis10.0
44hepatitis b10.0
45hepatitis10.0
46liver disease10.0
47acoustic neuroma10.0
48neuroma10.0
49melanotic neuroectodermal tumor10.0
50oculocerebrorenal syndrome10.0

Graphical network of the top 20 diseases related to Brain Cancer:



Diseases related to brain cancer

Clinical Features for Brain Cancer

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Drugs & Therapeutics for Brain Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Brain Cancer

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Anatomical Context for Brain Cancer

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Sources:
32MalaCards
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MalaCards organs/tissues related to Brain Cancer:

32
Brain, Breast, Lung, Testes, Pineal, Pituitary, Endothelial, Testis, Prostate, Bone, Liver, Colon, Thyroid, Salivary gland, Cervix, T cells, Skin, Kidney, Spinal cord

Animal Models for Brain Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Brain Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.4INSR, NANOG, BAX, PRDX4, EGFR, ARHGAP1
2MP:000538911.2PDGFRB, IL13, INSR, BAX, VEGFB, PRDX4
3MP:000537910.6PDGFRB, CRYM, PRDX4, BAX

Publications for Brain Cancer

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Sources:
50PubMed
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Articles related to Brain Cancer:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
Protein-protein interaction network analysis and gene set enrichment analysis in epilepsy patients with brain cancer. (24239228)
2014
2
Human breast cancer metastases to the brain display GABAergic properties in the neural niche. (24395782)
2014
3
Where are we now? And where are we going? A report from the Accelerate Brain Cancer Cure (ABC2) Low-grade Glioma Research Workshop. (24305708)
2014
4
DRR regulates AKT activation to drive brain cancer invasion. (24141773)
2013
5
Update on bevacizumab and other angiogenesis inhibitors for brain cancer. (23668489)
2013
6
Brain Metastases from Esophageal Cancer: Clinical Review of 26 Cases. (23435161)
2013
7
Nanotherapeutic approaches for brain cancer management. (24135564)
2013
8
Therapeutic links between Alzheimer's disease and brain cancer: drug discovery consequences. (23444291)
2013
9
Synthesis and antiproliferative activity of ammonium and imidazolium ionic liquids against T98G brain cancer cells. (23174892)
2012
10
Methylation status of O6-methylguanine-DNA-methyl transferase promoter region in non-small-cell lung cancer patients with brain metastasis. (22262716)
2012
11
Association between traumatic brain injury and the subsequent risk of brain cancer. (22320191)
2012
12
Acute stress in patients with brain cancer during primary care. (21717272)
2012
13
Brain cancer mortality rates increase with Toxoplasma gondii seroprevalence in France. (22285308)
2012
14
Solitary brain metastasis in a patient with ovarian cancer with BRCA2 mutation. (22753899)
2012
15
Translation and validation of the EORTC brain cancer module (EORTC QLQ-BN20) for use in Iran. (22607028)
2012
16
Nanoscale materials for tackling brain cancer: recent progress and outlook. (21506172)
2011
17
Comparisons of [18F]-1-deoxy-1-fluoro-scyllo-inositol with [18F]-FDG for PET imaging of inflammation, breast and brain cancer xenografts in athymic mice. (21982567)
2011
18
Cell phones and brain cancer: should you be worried? Statement linking cell phones to brain tumors causes fear, confusion. (22059254)
2011
19
Comparison of time trends in brain and central nervous system cancer mortality (1990-2006) between countries based on the WHO mortality database. (21273379)
2011
20
Patterns of missing mini mental status exam (MMSE) in radiation therapy oncology group (RTOG) brain cancer trials. (21603964)
2011
21
Bioprocessing of human glioblastoma brain cancer tissue. (20021271)
2010
22
Ganglioside GM3 Is Antiangiogenic in Malignant Brain Cancer. (20634908)
2010
23
Gamma Knife radiosurgery for brain metastases from primary breast cancer. (19345514)
2009
24
Brain metastases from colorectal cancer: risk factors, incidence, and the possible role of chemokines. (19423503)
2009
25
Case of brain infarction during cisplatin-based combined chemotherapy with bleomycin, etoposide and cisplatin for testicular cancer]. (19198224)
2009
26
Stroke-like syndrome in a middle aged Nigerian woman with metastatic brain cancer. (20425745)
2009
27
Magnetic resonance imaging for radiotherapy planning of brain cancer patients using immobilization and surface coils. (19687561)
2009
28
BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases. (19543317)
2009
29
Brain-type and liver-type fatty acid-binding proteins: new tumor markers for renal cancer? (19622156)
2009
30
Gamma Knife stereotactic radiosurgery for intracranial metastases from conventionally radioresistant primary cancers: outcome analysis of survival and control of brain disease. (19077767)
2009
31
Dietary zinc intake and brain cancer in adults: a case-control study. (17908366)
2008
32
Gastric cancer producing AFP/HCG which had a rapidly progressive course with metastasis to the brain discovered postoperatively]. (17485946)
2007
33
P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan. (17975156)
2007
34
Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain. (17483330)
2007
35
Stress and quality of life in brain cancer survivors. (18240672)
2007
36
Stem cells and brain cancer. (15925587)
2005
37
Complete resection of non-small-cell lung cancer and oligo-metastatic brain disease. (16336388)
2005
38
High-resolution longitudinal screening with magnetic resonance imaging in a murine brain cancer model. (14965447)
2003
39
Molecular mechanisms of tumor dissemination in primary and metastatic brain cancers. (11136998)
2000
40
Influence of radiotherapy on 6-sulphatoxymelatonin levels in the urine of brain cancer patients. (11455350)
2000
41
First-line high-dose chemotherapy +/- radiation therapy in patients with metastatic germ-cell cancer and brain metastases. (10907948)
2000
42
Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer. (10489993)
1999
43
Drug combination treats brain cancer. (10743546)
1999
44
Evaluating cluster alarms: a space-time scan statistic and brain cancer in Los Alamos, New Mexico. (9736881)
1998
45
Brain cancer mortality among French farmers: the vineyard pesticide hypothesis. (9570310)
1998
46
The use of significant others as proxy raters of the quality of life of patients with brain cancer. (9140337)
1997
47
Hydrogen magnetic resonance spectroscopy follow-up after radiation therapy of human brain cancer. Unexpected inverse correlation between the changes in tumor choline level and post-gadolinium magnetic resonance imaging contrast. (8748188)
1995
48
Serum cholesterol concentration and risk of brain cancer. (7866214)
1995
49
Magnetic field exposure in relation to leukemia and brain cancer mortality among electric utility workers. (7817968)
1995
50
Cerebrospinal fluid versus serum concentrations of 5-FU, allopurinol, and oxypurinol during treatment of metastatic brain cancer with 5-FU infusion, allopurinol, and radiation. (7060045)
1982

Genetic Variations for Brain Cancer

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Expression for genes affiliated with Brain Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Cancer

Search GEO for disease gene expression data for Brain Cancer.

Pathways for genes affiliated with Brain Cancer

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Sources:
51QIAGEN, 29KEGG, 59Tocris Bioscience, 4Cell Signaling Technology, 52R&D Systems, 37NCBI BioSystems Database, 49PharmGKB
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Pathways related to Brain Cancer according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1INSR, IL13, BAX, EGFR, VEGFB, PDGFRB
2
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11.1PDGFRB, EGFR, VEGFB, BAX, INSR, IL13
3
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11.1IL13, PDGFRB, INSR, VEGFB, EGFR, BAX
4
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11.1EGFR, IL13, INSR, VEGFB, PDGFRB, BAX
5
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11.0BAX, PDGFRB, EGFR, IL13, INSR
6
Hide members
11.0PDGFRB, EGFR, VEGFB, BAX, IL13
7
Hide members
11.0INSR, BAX, VEGFB, EGFR, PDGFRB
8
Hide members
11.0INSR, VEGFB, NANOG, PDGFRB, EGFR
9
Hide members
10.9ARHGAP1, PDGFRB, EGFR, INSR
10
Hide members
10.9INSR, PDGFRB, EGFR, VEGFB
1110.9INSR, EGFR, PDGFRB, VEGFB
1210.9VEGFB, PDGFRB, INSR, EGFR
1310.9PDGFRB, EGFR, VEGFB, BAX
1410.8EGFR, PDGFRB, INSR
1510.8INSR, EGFR, PDGFRB
1610.8EGFR, INSR, PDGFRB
1710.8INSR, EGFR, PDGFRB
18
Hide members
10.8PDGFRB, EGFR, BAX

Compounds for genes affiliated with Brain Cancer

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
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Compounds related to Brain Cancer according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1vegf4411.5VEGFB, PDGFRB, CT49, EGFR, BAX, INSR
2ly2940024411.3IL13, INSR, BAX, EGFR, PDGFRB
3retinoic acid44 2412.3NEFL, EGFR, CT49, IL13, BAX, PDGFRB
4docetaxel44 49 59 1114.2EGFR, PDGFRB, BAX, PRDX4
5agar4411.2PDGFRB, CT49, INSR, EGFR
6h2o24411.2IL13, INSR, PDGFRB, PRDX4, BAX
7sb 20358044 5912.1IL13, INSR, BAX, EGFR
8flavopiridol44 1112.1BAX, EGFR, PDGFRB
9gefitinib44 49 1113.1EGFR, INSR, PDGFRB
10pki-1664411.0EGFR, PDGFRB
11zd64744411.0EGFR, PDGFRB
12n,n-dimethylsphingosine44 5912.0BAX, EGFR
13ag 10244410.9INSR, EGFR
14homoharringtonine44 1111.9BAX, KLF10
15gemcitabine44 49 1112.9EGFR, BAX, PDGFRB
16pd 98,0594410.9INSR, BAX, EGFR, IL13
17ursolic acid4410.9BAX, INSR
18ag-12964410.8EGFR, PDGFRB
19su54164410.7EGFR, PDGFRB
20capecitabine44 49 1112.7PDGFRB, EGFR
21wortmannin4410.6INSR, BAX, IL13, PDGFRB
22shikonin4410.6EGFR, BAX

GO Terms for genes affiliated with Brain Cancer

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16Gene Ontology
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Biological processes related to Brain Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell migrationGO:03033510.9INSR, MIEN1, EGFR, PDGFRB
2positive regulation of protein kinase B signaling cascadeGO:05189710.8VEGFB, INSR, EGFR
3positive regulation of release of sequestered calcium ion into cytosolGO:05128110.7IL13, BAX
4regulation of peptidyl-tyrosine phosphorylationGO:05073010.6EGFR, PDGFRB
5positive regulation of ERK1 and ERK2 cascadeGO:07037410.5EGFR, VEGFB, PDGFRB

Molecular functions related to Brain Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:00471310.8INSR, EGFR, PDGFRB
2receptor signaling protein tyrosine kinase activityGO:00471610.4INSR, EGFR

Products for genes affiliated with Brain Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brain Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet