Brain Disease malady

NINDS: Encephalopathy is a term for any diffuse disease of the brain that alters brain function or structure. Encephalopathy may be caused by infectious agent (bacteria, virus, or prion), metabolic or mitochondrial dysfunction, brain tumor or increased pressure in the skull, prolonged exposure to toxic elements (including solvents, drugs, radiation, paints, industrial chemicals, and certain metals), chronic progressive trauma, poor nutrition, or lack of oxygen or blood flow to the brain. The hallmark of encephalopathy is an altered mental state. Depending on the type and severity of encephalopathy, common neurological symptoms are progressive loss of memory and cognitive ability, subtle personality changes, inability to concentrate, lethargy, and progressive loss of consciousness. Other neurological symptoms may include myoclonus (involuntary twitching of a muscle or group of muscles), nystagmus (rapid, involuntary eye movement), tremor, muscle atrophy and weakness, dementia, seizures, and loss of ability to swallow or speak. Blood tests, spinal fluid examination, imaging studies, electroencephalograms, and similar diagnostic studies may be used to differentiate the various causes of encephalopathy.³¹

MalaCards: Brain Disease, also known as encephalopathy, is related to muscle-eye-brain disease and prion disease. An important gene associated with Brain Disease is MEB (muscle-eye-brain disease), and among its related pathways are Neuroscience and Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1. The compounds threonine and h2o2 have been mentioned in the context of this disorder. Affiliated tissues include brain, monocytes and t cells, and related mouse phenotypes are respiratory system and other.

Aliases & Descriptions:

brain disease 6 encephalopathy 6 7 31 32

encephalopathies 43 brain diseases 43

Diseases related to brain disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 944)

id	Related Disease	Score	Top Affiliating Genes
1	muscle-eye-brain disease	36.4	GCNT2, LAMA2, LAMB2, LARGE, FKRP, FKTN
2	prion disease	32.8	CLU, APP, MAPT, F8, PSEN1, PSEN2
3	aicardi-goutieres syndrome	32.2	SERPINI1, SERPINA3, CLN5, BCHE, CHAT, BACE1
4	scrapie	31.2	CLU, APOE, APP, ENO2, MAPT, NOS1
5	west syndrome	30.8	CDKL5, MECP2, TPH1, PVALB, POMC, SLC1A3
6	alcoholism	30.1	CNR1, GSR, GRIN2A, GRIN2B, MAPT, MAOB
7	lactic acidosis	29.7	PIK3C2A, PIK3CG, APP, HSPG2, HSPA5, CAMK2G
8	epilepsy syndrome	29.3	PIK3CG, CNR1, SERPINI1, CLU, CLN5, BDNF
9	progressive supranuclear palsy	29.2	PARK2, CHAT, CDK5, APOE, APP, MAPT
10	creutzfeldt-jakob syndrome	29.0	SERPINA3, MT3, S100B, APOE, APP, FABP3
11	immunodeficiency	28.8	PIK3CD, BLZF1, PARK2, CIITA, CD79A, CDKN3
12	walker-warburg syndrome	28.7	LAMA2, LAMB2, LARGE, ISPD, FKRP, FKTN
13	liver cirrhosis	28.6	CNR1, SERPINI1, SEPP1, SERPINA3, AVP, FOS
14	aphasia	28.6	BRAP, APOE, APP, MAPT, CBS, SNCA
15	myoclonus	28.5	SERPINI1, CLN5, PARK2, CDKN3, GSK3B, MECP2
16	cerebral atrophy	28.2	CLN5, APOE, MAPT, TREX1, CREB1, RPS27A
17	febrile seizures	28.1	CNR1, BDNF, KCNQ2, SCN8A, IL1B, ENO2
18	alzheimer's disease	28.0	CLU, APOE, APP, MAPT, IDE, NRG1
19	convulsions	28.0	PIK3C2A, BDNF, KCNQ2, FOS, IL1B, APOE
20	tremor	28.0	CNR1, PARK2, SCN8A, CDKN3, APOA1, APOB
21	encephalomyopathy	27.9	CAT, AIFM1, CYCS, RPS27A, COX5A, DNAH8
22	normal pressure hydrocephalus	27.6	BDNF, APOE, MAPT, ACE, GFAP, NPY
23	spasticity	27.6	CNR1, ATXN3, JUN, CDK5, CDKN3, MECP2
24	motor neuron disease	27.6	BDNF, CHAT, CDK5, GRIA2, APOE, MAPT
25	insomnia	27.4	HTR1A, HTR3A, CAT, HCRT, TSPO, PRNP
26	central nervous system disease	27.3	ITGAM, IL1B, APOH, CCR5, NOS2, GFAP
27	intractable epilepsy	27.3	BDNF, CDK5, CDKL5, GSR, GRIA2, MAPK3
28	toxic encephalopathy	27.2	PIK3CB, PIK3CD, PIK3CA, PIK3CG, BDNF, BCHE
29	aids dementia complex	27.1	BDNF, S100B, IL1B, MBP, CCR5, TPPP3
30	autonomic dysfunction	27.0	BDNF, ATXN3, MECP2, APOA1, MAPT, ALB
31	hepatic encephalopathy	26.4	S100B, ATXN3, MAOB, ALB, CAMK2G, GLUL
32	acute liver failure	26.3	IL1B, MAPK8, MAPK9, F3, ALB, GLUL
33	hepatitis	26.3	PIK3CB, PIK3CD, PIK3CA, PIK3C2A, PIK3CG, CNR1
34	neurodegenerative disease	26.2	PIK3CG, CNR1, SERPINI1, SEPP1, SERPINA3, BLZF1
35	hydrocephalus	26.2	BDNF, FKTN, APOB, APOE, APP, MBP
36	peripheral neuropathy	26.1	BDNF, MTR, AVP, ATXN3, APOA1, APOE
37	brain ischemia	25.9	RBFOX3, SELP, BDNF, CDKN3, FOS, GRIN2A
38	myopathy	25.7	PIK3C2A, SEPW1, BLZF1, CLU, PARK2, BDNF
39	cerebral palsy	25.5	S100B, CD79A, GSR, IL1B, APOE, GPX4
40	plasmodium falciparum malaria	25.5	SELP, GSR, FABP3, F3, TNF, PTGS2
41	hemolytic-uremic syndrome	25.1	SELP, CLU, CD79A, FGF2, IL1B, APOH
42	protein s deficiency	25.1	PIK3C2A, BLZF1, LAMA2, APOA1, APOB, APOE
43	carcinoid tumors	25.1	BCL2, S100B, ENO2, MAP2, CCK, CALB2
44	hypertrophic cardiomyopathy	24.9	PIK3C2A, SELP, LAMA2, MMP2, FKTN, FABP3
45	seizures	24.9	PIK3C2A, PDCD10, CNR1, SERPINI1, CLN5, PARK2
46	influenza	24.7	PIK3CB, PIK3CD, PIK3CA, PIK3C2A, PIK3CG, BLZF1
47	growth hormone deficiency	24.5	CD79A, MMP2, APOA1, APOB, APOE, ALB
48	cataract	24.4	GCNT2, BLZF1, FTL, CDKL5, FOS, GSR
49	sepsis	24.3	SELP, BLZF1, CIITA, AVP, CDKN3, ITGAM
50	jaundice	24.1	CD79A, ITGAM, GSR, IL1B, APP, CCK

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to brain disease:

²²

MGI Mouse Phenotypes related to brain disease:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	11.4	SELP, PARK2, BDNF, KCNQ2, SCN8A, CHRNA7
2	other phenotype	MP:0005395	11.2	CNR1, CLU, BACE1, LAMA2, FKTN, GSK3A
3	endocrine/exocrine gland phenotype	MP:0005379	11.1	LAMA2, MECP2, HTT, TRH, DMD, NRG1
4	normal phenotype	MP:0002873	10.7	PDCD10, BLM, PAWR, BDNF, CIITA, CHAT
5	mortality/aging	MP:0010768	10.6	PIK3CB, PIK3CA, PIK3C2A, PDCD10, CNR1, SELP
6	craniofacial phenotype	MP:0005382	10.4	PDCD10, BDNF, LAMA2, LARGE, FKRP, GSK3B
7	hematopoietic system phenotype	MP:0005397	10.3	PDCD10, KIAA0101, GCNT2, BLM, PAWR, BCL2
8	no phenotypic analysis	MP:0003012	10.1	PIK3CD, CNR1, BLM, BDNF, SCN8A, BACE1
9	taste/olfaction phenotype	MP:0005394	9.8	CNR1, BDNF, ENO2, MAPT, MAPK1, HTT
10	behavior/neurological phenotype	MP:0005386	9.8	PIK3CA, PDCD10, CNR1, GCNT2, SELP, SERPINI1
11	renal/urinary system phenotype	MP:0005367	9.7	GCNT2, SELP, CLU, BCL2, BAX, LAMB2
12	embryogenesis phenotype	MP:0005380	9.5	PIK3CB, PIK3CA, PDCD10, BLM, FOS, FKTN
13	digestive/alimentary phenotype	MP:0005381	9.4	BDNF, BCL2, LARGE, APOE, MAPK8, MAPK9
14	nervous system phenotype	MP:0003631	9.3	PDCD10, CNR1, SELP, CLN5, PARK2, BDNF
15	growth/size phenotype	MP:0005378	9.3	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PDCD10, CNR1
16	liver/biliary system phenotype	MP:0005370	9.3	SEPP1, FTH1, GSK3A, GSK3B, APOA1, APOB
17	hearing/vestibular/ear phenotype	MP:0005377	9.2	BDNF, BCL2, SCN8A, BAX, LAMA2, LARGE
18	immune system phenotype	MP:0005387	9.1	PIK3CD, PDCD10, KIAA0101, GCNT2, SELP, CLU
19	skeleton phenotype	MP:0005390	8.8	PIK3CD, PIK3CG, CNR1, PARK2, SCN8A, CHAT
20	integument phenotype	MP:0010771	8.8	PIK3CG, PDCD10, CNR1, GCNT2, SELP, BLM
21	adipose tissue phenotype	MP:0005375	8.5	PIK3CA, PIK3C2A, CNR1, BCL2, GSK3A, MECP2
22	reproductive system phenotype	MP:0005389	8.4	PIK3CA, SEPP1, BCHE, KCNQ2, SCN8A, CHAT
23	muscle phenotype	MP:0005369	8.1	PIK3CA, PIK3CG, PDCD10, CLU, PARK2, BCL2
24	vision/eye phenotype	MP:0005391	7.5	PIK3CA, PDCD10, SELP, CLN5, BDNF, BCL2
25	cellular phenotype	MP:0005384	6.3	PIK3CB, PIK3CD, PIK3CA, PIK3CG, PDCD10, CNR1
26	homeostasis/metabolism phenotype	MP:0005376	5.7	PIK3CB, PIK3CD, PIK3CA, PIK3C2A, PIK3CG, CNR1
27	cardiovascular system phenotype	MP:0005385	5.5	PIK3CB, PIK3CD, PIK3CA, PIK3CG, PDCD10, SELP
28	tumorigenesis	MP:0002006	5.4	PIK3CB, PIK3CA, PDCD10, BLM, BCL2, BCL2L1

Articles related to brain disease:

(show all 36)

id	Title	Authors	Year	Affiliating Genes
1	Muscle-Eye-Brain disease. (20215985)	Shenoy A.M.... Tseng B.S.	2010	POMGNT1
2	Glyconanoparticles allow pre-symptomatic in vivo imag ing of brain disease. (19106304)	van Kasteren S.I.... Davis B.G.	2009	SELP
3	Small-molecule suppression of misfolding of mutated h uman carbonic anhydrase II linked to marble brain disease. (19415900)	Almstedt K.... HammarstrAPm P.	2009	CA2
4	Thermodynamic interrogation of a folding disease. Mutant mapping of position 107 in human carbonic anhydrase II linked to marble brain disease. (18189416)	Almstedt K.... Hammarstrom P.	2008	CA2
5	Severe muscle-eye-brain disease is associated with a homozygous mutation in the POMGnT1 gene. (17881266)	Teber S.... Deda G.	2008	POMGNT1
6	Prenatal diagnosis of muscle-eye-brain disease. (17154333)	Balci B.... Dincer P.	2007	POMGNT1
7	Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner. (17212813)	Chen P.Y.... Wu C.W.	2007	SERPINI1, PDCD10
8	Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. (17143274)	Hur E.M.... Steinman L.	2007	SPP1
9	Roles of prostaglandin synthesis in excitotoxic brain diseases. (17629358)	Takemiya T.... Yamagata K.	2007	COX5A
10	Role of COX-2 in inflammatory and degenerative brain diseases. (17612048)	Minghetti L.	2007	PTGS2
11	Novel POMGnT1 mutations define broader phenotypic spectrum of muscle-eye-brain disease. (17906881)	Hehr U.... Winkler J.	2007	POMGNT1
12	A genetic model for muscle-eye-brain disease in mice lacking protein O-mannose 1,2-N-acetylglucosaminyltransferase (POMGnT1). (16458488)	Liu J.... Hu H.	2006	POMGNT1
13	Carriers and patients with muscle-eye-brain disease c an be rapidly diagnosed by enzymatic analysis of fibroblasts and lymphoblasts. (16427280)	Vajsar J.... Schachter H.	2006	MGAT1
14	Muscle-eye-brain disease. Presentation of one case with genetic study. (15954036)	Pascual-Castroviejo I.... Cormand B.	2005	POMGNT1
15	The function of the neuronal proteins Shc and huntingtin in stem cells and neurons: pharmacologic exploitation for human brain diseases. (15965106)	Zuccato C.... Cattaneo E.	2005	HTT
16	Marble brain disease in two Saudi Arabian siblings. (16156988)	Muzalef A.... Al-Trabolsi H.A.	2005	CA2
17	POMGnT1 mutation and phenotypic spectrum in muscle-eye-brain disease. (15466003)	Diesen C.... Lehesjoki A.-E.	2004	POMGNT1
18	Clinical spectrum of muscle-eye-brain disease: from the typical presentation to severe autistic features. (15938569)	Haliloglu G.... Topaloglu H.	2004	POMGNT1
19	Mutations in the FKRP gene can cause muscle-eye-brain disease and Walker-Warburg syndrome. (15121789)	Beltran-Valero de Bernabe D.... Muntoni F.	2004	FKRP
20	MCP-1 and CCR2 contribute to non-lymphocyte-mediated brain disease induced by Fr98 polytropic retrovirus infection in mice: role for astrocytes in retroviral neuropathogenesis. (15163738)	Peterson K.E.... Chesebro B.	2004	CCR5
21	Spastic diplegia and periventricular white matter abnormalities in 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency, a defect of isoleucine metabolism: differential diagnosis with hypoxic-ischemic brain diseases. (15059617)	Poll-The B.T.... Duran M.	2004	HSD17B10
22	Selenium and selenoproteins in the brain and brain diseases. (12807419)	Chen J.... Berry M.J.	2003	PRDX5, DIO2, SEPP1
23	Loss-of-function of an N-acetylglucosaminyltransferase, POMGnT1, in muscle-eye-brain disease. (12788071)	Manya H.... Endo T.	2003	GCNT2, POMGNT1
24	Worldwide distribution and broader clinical spectrum of muscle-eye- brain disease. (12588800)	Taniguchi K.... Toda T.	2003	POMGNT1
25	Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases. (12528815)	Aboul-Enein F.... Lassmann H.	2003	MAG
26	Deficiency of alpha-dystroglycan in muscle-eye-brain disease. (11883957)	Kano H.... Toda T.	2002	POMGNT1
27	ACE gene polymorphism in patients with ischemic brain disease (12830537)	Skvortsova V.I.... Kondrat'eva E.A.	2001	ACE
28	Monocyte activation and differentiation augment human endogenous retrovirus expression: implications for inflammatory brain diseases. (11601494)	Johnston J.B.... Power C.	2001	TNF, ERVW-1, ERVK-6
29	Neurodegenerative disorders and ischemic brain diseases. (11321043)	Mattson M.P.... Culmsee C.	2001	PAWR
30	Muscle membrane-skeleton protein changes and histopat hological characterization of muscle-eye-brain disease. (10677859)	Auranen M.... Somer H.	2000	LAMB2
31	Assignment of the muscle-eye-brain disease gene to 1p32-p34 by linkage analysis and homozygosity mapping. (9915951)	Cormand B.... Lehesjoki A.E.	1999	POMGNT1, MEB
32	Endothelin peptides in brain diseases. (8916291)	Nie X.J.... Olsson Y.	1996	EDN1
33	Anticardiolipin antibodies in patients with ischemic brain disease (8560861)	IvaniseviA8 V.... PavloviA8 G.	1994	APOH
34	Sensitivity of atherosclerosis indices in patients with ischemic brain disease (8560842)	MariA8 D.... JoviA8 P.	1994	APOA1
35	Patterns of lipid change in serum as a risk factor for ischemic brain disease (8114988)	Wender M.... SmoliA8ska K.	1993	APOB
36	Activity of antioxidant protection enzymes and content of lipid peroxidation products in blood serum and cerebrospinal fluid in patients with ischemic brain disease (1413627)	Dzhandzhgava T.G.... Shakarishivili R.R.	1992	SOD1, GSR, CAT

Genes related to brain disease according to GeneCards:

(show top 50)    (show all 251)

id	Symbol	Description	Score	GeneCards Section Context
1	MEB	muscle-eye-brain disease	11.0	Aliases & Descriptions, Publications
2	POMGNT1	protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase	11.0	Publications
3	POMT1	protein-O-mannosyltransferase 1	11.0
4	FKRP	fukutin related protein	11.0	Publications
5	DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	11.0
6	FKTN	fukutin	11.0
7	LAMA2	laminin, alpha 2	11.0
8	LARGE	like-glycosyltransferase	11.0
9	DMD	dystrophin	11.0
10	FAM3A	family with sequence similarity 3, member A	11.0	Orthologs
11	FAM3D	family with sequence similarity 3, member D	11.0	Orthologs
12	FAM3B	family with sequence similarity 3, member B	11.0	Orthologs
13	LAMB2	laminin, beta 2 (laminin S)	11.0	Publications
14	FAM3C	family with sequence similarity 3, member C	11.0	Orthologs
15	HSPB6	heat shock protein, alpha-crystallin-related, B6	11.0
16	CLN5	ceroid-lipofuscinosis, neuronal 5	11.0
17	TPPP3	tubulin polymerization-promoting protein family member 3	11.0
18	MGAT1	mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	11.0	Publications
19	POMT2	protein-O-mannosyltransferase 2	11.0
20	CSNK1A1L	casein kinase 1, alpha 1-like	11.0
21	CA2	carbonic anhydrase II	11.0	Publications
22	MT3	metallothionein 3	11.0
23	MARCKS	myristoylated alanine-rich protein kinase C substrate	11.0
24	GLO1	glyoxalase I	11.0
25	PRDX5	peroxiredoxin 5	11.0	Publications
26	NISCH	nischarin	11.0
27	CSNK1D	casein kinase 1, delta	11.0
28	CX3CL1	chemokine (C-X3-C motif) ligand 1	11.0
29	HRH3	histamine receptor H3	11.0
30	GSK3A	glycogen synthase kinase 3 alpha	11.0
31	DISC1	disrupted in schizophrenia 1	11.0
32	ERVW-1	endogenous retrovirus group W, member 1	11.0	Publications
33	CLU	clusterin	11.0
34	COX5A	cytochrome c oxidase subunit Va	11.0	Publications
35	GLUL	glutamate-ammonia ligase	11.0
36	CRYAB	crystallin, alpha B	11.0
37	NTF3	neurotrophin 3	11.0
38	OPRK1	opioid receptor, kappa 1	11.0
39	DUSP19	dual specificity phosphatase 19	11.0
40	IDE	insulin-degrading enzyme	11.0
41	DRD1	dopamine receptor D1	11.0
42	DPYSL2	dihydropyrimidinase-like 2	11.0
43	GRIA2	glutamate receptor, ionotropic, AMPA 2	11.0
44	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11.0
45	IFNAR1	interferon (alpha, beta and omega) receptor 1	11.0
46	CIITA	class II, major histocompatibility complex, transactivator	11.0
47	PSEN2	presenilin 2 (Alzheimer disease 4)	11.0
48	PVALB	parvalbumin	11.0
49	BACE2	beta-site APP-cleaving enzyme 2	11.0
50	BACE1	beta-site APP-cleaving enzyme 1	11.0

Pathways related to brain disease according to GeneDecks:

(show top 50)    (show all 276)

id	Pathway	Score	Top Affiliating Genes
1	Neuroscience3	11.3	APP, GRIN2B, GRIN2A, GRIA2, GRIA1, MECP2
2	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	10.8	MAPK9, PIK3CD
3	Alzheimers Disease Pathway36	10.8	GSK3B, BACE2, CDK5, APOE, APP, PSEN2
4	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	10.6	PIK3CB, PIK3CD, MAPK3, MAPK9, AKT1, CYCS
5	Colorectal cancer20	10.5	MAPK9, PIK3CB, PIK3CD, PIK3CG, FOS, GSK3B
6	Development_Endothelin-1/EDNRA signaling41	10.5	CALM3, CALM1, CAMK2G, EDN1
7	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.2	BCL2, CDK5, CASP9, CYCS, NTRK1, NGF
8	Neuropathic Pain-Signaling in Dorsal Horn Neurons36	10.2	CREB1, CAMK2G, NTRK2, GRIA2, GRIA1, SCN8A
9	Fc epsilon RI signaling pathway20	10.1	PIK3CB, PLA2G2A, PLA2G4A, PLA2G1B, TNF, PIK3CD
10	VEGF signaling pathway20	9.7	PRKCA, PLA2G2A, PLA2G4A, PIK3CD, PTGS2, AKT1
11	Endothelin-1 Signaling Pathway36	9.6	CX3CL1, IL1B, MAPK3, MAPK1, PRKCA, EDN1
12	DHA Signaling36	9.6	PLA2G1B, NRG1, NTRK2, NTRK1, NTF3, CYCS
13	Development Endothelin-1/EDNRA signaling10	9.5	CALM3, PIK3CD, MAPK8, MAPK3, MAPK1, MAPK9
14	Development_Thrombopoietin-regulated cell processes41	9.4	FOS, GSK3A, GSK3B, MAPK3, MAPK1, AKT1
15	Development Thrombopoietin-regulated cell processes10	9.4	PIK3CB, PIK3CA, FOS, GSK3A, GSK3B, JUN
16	ILK Signaling36	9.3	NTRK1, CASP9, AKT1, TNFRSF1A, BDNF, HIF1A
17	Cholinergic synapse20	9.3	MAPK3, MAPK1, AKT1, ACHE, PRKCA, CREB1
18	Alzheimers disease20	9.3	PSEN1, COX5A, NOS1, SNCA, PSEN2, CALM1
19	Development Neurotrophin family signaling10	9.3	PIK3CB, PIK3CD, PIK3CA, BDNF, JUN, BAX
20	Development_Neurotrophin family signaling41	9.2	TP53, NTF3, NTRK1, NTRK2, NGF, AKT1
21	Pathogenesis of ALS36	9.1	SLC1A2, SLC1A3, BCL2, BCL2L1, SOD1, CYCS
22	Development_HGF signaling pathway41	9.1	MAPK3, MAPK1, MAPK9, AKT1, MAPK8, JUN
23	ErbB signaling pathway20	9.1	MAPK3, MAPK8, MAPK9, CAMK2G, AKT1, JUN
24	Development_EGFR signaling pathway41	9.1	STAT1, PIK3CA, PRKCA, PIK3CB, MAPK9, PIK3CD
25	Small cell lung cancer20	9.0	AKT1, PIK3CG, LAMB2, LAMA2, BCL2L1, BCL2
26	Development FGFR signaling pathway10	8.8	AKT1, JUN, PIK3CA, PIK3CD, PIK3CB, MAPK9
27	UVA-Induced MAPK Signaling36	8.7	CASP3, MAPK1, FOS, TP53, CYCS, STAT1
28	Neurotrophin signaling pathway20	8.7	PIK3CG, PIK3CB, PIK3CD, AKT1, TP53, NTF3
29	TRKA Signaling36	8.5	CYCS, CREB1, CASP9, TP53, NTRK1, BAX
30	Ceramide Pathway36	8.5	JUN, FOS, CYCS, TNFRSF1A, TNF, AKT1
31	Amyotrophic lateral sclerosis (ALS)20	8.5	GRIA1, BAX, BCL2L1, BCL2, SOD1, NOS1
32	Immune response IL-1 signaling pathway10	8.5	STAT1, CP, F3, EDN1, NOS2, PTGS2
33	Immune response_IL-1 signaling pathway41	8.5	STAT1, CP, MAPK8, JUN, EDN1, NOS2
34	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	8.4	JUN, BAX, BCL2, SOD2, FOS, MAPK8
35	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	8.4	BCL2, BAX, JUN, MAPK1, ESR1, MAPK8
36	Influenza A20	8.3	PIK3CB, PIK3CD, PIK3CA, PIK3CG, CIITA, MX1
37	Osteoclast differentiation20	8.3	MAPK3, STAT1, MAPK9, IFNAR1, AKT1, TNF
38	Apoptotic Pathways Triggered By HIV136	8.3	MAPK9, MAPK8, CYCS, TNFRSF1A, TNF, TP53
39	Toll-like receptor signaling pathway20	8.3	IFNAR1, MAPK9, MAPK1, MAPK3, STAT1, MAPK8
40	Toxoplasmosis20	8.3	PIK3CB, PIK3CD, PIK3CA, PIK3CG, BCL2, BCL2L1
41	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	8.1	CASP9, PIK3CB, PIK3CD, NRG1, NGF, NTRK1
42	MAPK signaling pathway20	8.1	CASP3, MAPK8, MAPT, FOS, JUN, BDNF
43	Chagas disease (American trypanosomiasis)20	8.1	MAPK3, PIK3CG, TNF, TNFRSF1A, NOS2, AKT1
44	Tuberculosis20	8.0	CIITA, BCL2, MAPK3, MAPK8, IL1B, ITGAM
45	Apoptosis20	8.0	PIK3CB, PIK3CD, PIK3CA, PIK3CG, BCL2, BCL2L1
46	Molecular Mechanisms of Cancer36	7.9	PSEN1, PSEN2, PRKCA, EP300, HIF1A, PF4
47	Pertussis20	7.6	IL1B, TNF, FOS, ITGAM, JUN, MAPK3
48	MIF Regulation of Innate Immune Cells36	7.3	TP53, IL1B, FOS, JUN, BAX, BCL2
49	14-3-3 Induced Apoptosis36	7.2	FOS, MAPK3, MAPK1, MAPK9, CASP9, AKT1
50	Pathways in cancer20	7.1	FGF2, PRKCA, EP300, HIF1A, NOS2, MAPK8

Compounds related to brain disease according to GeneDecks:

(show top 50)    (show all 567)

id	Compound	Score	Top Affiliating Genes
1	threonine32	11.4	PARK2, CHRNA7, MT3, AVP, CDK5, GSK3A
2	h2o232	11.3	PIK3CB, PIK3CG, SEPP1, BLZF1, CLU, PARK2
3	lithium32 34 9 18 9	15.1	BDNF, CDK5, GSK3A, GSK3B, GRIN2B, MAPT
4	silver32	11.1	SERPINA3, BLZF1, BDNF, CHAT, MBP, ENO2
5	lipid32	10.9	PIK3CB, PIK3CD, PIK3CA, PIK3C2A, PIK3CG, CNR1
6	inositol32	10.8	PIK3CB, PIK3CD, BDNF, CD79A, GSK3B, MBP
7	potassium32 9 18 9	13.7	PIK3CA, PIK3C2A, BLZF1, BDNF, BCHE, KCNQ2
8	phospholipid32	10.7	PIK3CB, BLZF1, CLU, CHAT, BACE1, MTR
9	peroxynitrite32	10.5	SEPP1, GSR, APOH, GPX1, CAT, TPH1
10	atropine32 9 9	12.5	BCHE, CHRNA7, CCK, HSPG2, TRH, DRD1
11	glutamate32	10.5	PIK3CB, PIK3CA, CNR1, BLZF1, CLU, BCHE
12	bromodeoxyuridine32	10.5	PIK3CA, BDNF, CIITA, S100B, FGF2, ENO2
13	k252a32	10.4	PIK3CG, BDNF, FGF2, GRIA1, MAPK8, MAPK1
14	citrate32	10.2	PIK3C2A, SELP, BLZF1, CD79A, CDKN3, FGF2
15	egcg32	10.2	PIK3CG, BCL2L1, APP, MAPK8, MAPK3, HSPG2
16	phosphatidylcholine32	10.1	PIK3CB, CNR1, CHAT, CD79A, FGF2, APOA1
17	quinacrine32 9 9	12.1	SELP, GSR, APOH, HSPG2, CYP3A4, CYP3A5
18	selegiline32 9 9	12.0	BDNF, BCHE, MAOB, CAT, CYP3A4, CYP2A6
19	dmso32	10.0	SELP, ITGAM, APOB, MAP2, GPX4, F3
20	pkcs32	9.9	PIK3CB, PIK3CG, PAWR, FOS, MBP, MAPK8
21	valproate32	9.9	BDNF, CD79A, GSK3B, GSR, MECP2, APOA1
22	estrogen32	9.7	PIK3CB, SERPINA3, CLU, PARK2, BDNF, CHAT
23	phosphatidylserine32 9 9	11.7	BCL2, CD79A, MAPT, MARCKS, CASP9, AIFM1
24	manganese superoxide32	9.6	BCL2L1, GSR, GPX4, GPX1, HSPB1, HSPA4
25	gsno32	9.5	SELP, JUN, CDKN3, GSR, CASP3, CAT
26	retinoid32	9.5	BAX, JUN, ITGAM, FOS, MAPK8, CASP9
27	alpha tocopherol32	9.5	CDKN3, ITGAM, GSR, APOA1, APOB, APOE
28	forskolin32 42 9 9	12.3	BLZF1, BDNF, CHAT, S100B, JUN, ITGAM
29	opiate32	9.2	APP, CCR5, CCK, DRD1, NTRK1, CREB1
30	okadaic acid32 42	10.2	PIK3CA, BLZF1, PARK2, BCL2, BCL2L1, JUN
31	tyrosine32	9.1	PIK3CB, PIK3CD, PIK3CA, PIK3C2A, PIK3CG, SELP
32	s-nitroso-n-acetylpenicillamine32	9.0	IL1B, HSPA4, CASP3, CAT, CASP9, HMOX1
33	simvastatin32 34 42 9 18 9	13.9	PIK3C2A, SELP, BCHE, CIITA, BACE1, ITGAM
34	aspirin32 34 18	10.9	CNR1, SELP, BCHE, CD79A, ITGAM, MMP2
35	methotrexate32 34 42 9 9	12.6	PIK3C2A, SERPINA3, MTR, CD79A, MMP2, GSR
36	vinblastine32 9 9	10.3	BDNF, BCL2, BCL2L1, BAX, JUN, MMP2
37	serine32	7.9	PIK3CB, PIK3CD, PIK3CA, PIK3CG, CNR1, SERPINI1
38	etoposide32 42 9 9	10.7	PIK3CB, PIK3CA, PIK3CG, CLU, BCL2, BCL2L1
39	wortmannin32 42	8.6	PIK3CB, PIK3CD, PIK3CA, PIK3C2A, PIK3CG, BDNF
40	butyrate32	7.5	BLZF1, CLU, BCHE, BCL2, BCL2L1, CHAT
41	paclitaxel32 34 9 9	10.5	PIK3CA, PIK3CG, CLU, PARK2, BDNF, BCL2
42	ly29400232	7.4	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, JUN, CDKN3
43	15-deoxy-delta-12,14-prostaglandin j232	7.4	PIK3CG, BCL2L1, JUN, FOS, FGF2, IL1B
44	retinoic acid32 42 18	8.9	PIK3CA, PIK3CG, GCNT2, SELP, BLZF1, CLU
45	quercetin32 42 9 18 9	10.8	PIK3CB, PIK3CD, PIK3CA, PIK3C2A, PIK3CG, BCL2
46	arsenite32 18	7.8	PIK3CA, PIK3CG, BCL2, BCL2L1, BAX, JUN
47	vegf32	6.7	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, SELP, CLU
48	resveratrol32 9 18 9	9.4	PIK3CA, PIK3CG, BCL2, BCL2L1, BAX, JUN
49	curcumin32	5.8	PIK3CG, BCL2, BCL2L1, BAX, JUN, MMP2
50	pdtc32	5.8	PIK3CA, PIK3CG, BCL2, BCL2L1, JUN, MMP2

Cellular components related to brain disease according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	perinuclear region of cytoplasm	GO:048471	11.1	NOS2, NDOR1, ACHE, HCRT, TF, PRDX5
2	axon	GO:030424	11.1	DRD1, SNCA, PVALB, STAT1, SLC6A3, ADCY10
3	neuronal cell body	GO:043025	11.0	SNCAIP, DPYSL2, DBH, PRKCA, SOD1, SLC6A3
4	Golgi apparatus	GO:005794	10.3	ESR1, GLUL, CA4, CAT, CRYAB, PLA2G4A
5	endoplasmic reticulum	GO:005783	10.1	PRNP, PSEN2, PSEN1, PLA2G2A, CYP2B6, PRKCA
6	terminal button	GO:043195	10.1	ADORA1, DBH, DPYSL2, NTRK2, CCK, GRIN2B
7	cell surface	GO:009986	10.0	TNF, TNFRSF1A, DMD, CYP3A4, NTRK1, NTRK2
8	plasma membrane	GO:005886	9.8	NISCH, HRH3, CA4, CAMK2G, CAT, CASP3
9	secretory granule	GO:030141	9.8	POMC, DBH, TF, HCRT, PLA2G2A, PLA2G1B
10	protein complex	GO:043234	9.6	DPYSL2, SYP, PSEN2, PRKCA, SOD1, RTN4
11	endoplasmic reticulum membrane	GO:005789	9.4	CYP2A6, CYP2B6, CYP4X1, CYP3A5, CYP2J2, PLA2G4A
12	mitochondrion	GO:005739	9.0	CREB1, SNCA, DISC1, TP53, AIFM1, ETHE1
13	cytoplasm	GO:005737	8.7	NRG1, SNCAIP, SNCA, CRYAB, NOS1, NOS2
14	cytosol	GO:005829	8.3	EPM2A, ADCY10, CSNK1D, SOD1, PPARGC1A, NTRK2
15	extracellular region	GO:005576	8.1	TRH, FGF2, GTDC2, MMP2, AVP, S100B
16	extracellular space	GO:005615	8.0	CP, TNFRSF1A, TNF, HMOX1, CA2, HSPG2

Biological processes related to brain disease according to GeneDecks:

(show top 50)    (show all 56)

id	Name	GO ID	Score	Top Affiliating Genes
1	nervous system development	GO:007399	11.1	CAMK2G, NTF3, NRG1, ACHE, DPYSL2, ADORA1
2	locomotory behavior	GO:007626	11.1	SLC6A3, SOD1, DBH, TH, NRG1, HTT
3	cellular nitrogen compound metabolic process	GO:034641	10.8	TPH1, DIO2, ODC1, TH, DBH, POMC
4	activation of MAPKK activity	GO:000186	10.7	PSEN1, NTRK1, F2R
5	visual learning	GO:008542	10.7	DBH, CDK5, MECP2, GRIN2A, APP, HTT
6	phosphatidylinositol-mediated signaling	GO:048015	10.7	NGF, CREB1, NTRK1, AKT1, CASP9, GSK3B
7	regulation of excitatory postsynaptic membrane potential	GO:060079	10.6	MECP2, GRIN2A, GRIN2B, SNCA, HCRT, ADORA1
8	cell death	GO:008219	10.6	SNCAIP, PDYN, NDOR1, POLG, SLC6A3, GBA
9	response to cocaine	GO:042220	10.5	SLC6A3, DPYSL2, HTR3A, GRIN2B, GRIN2A, CNR1
10	synaptic transmission	GO:007268	10.4	ACHE, PDYN, CREB1, SST, GLUL, CAMK2G
11	glutathione metabolic process	GO:006749	10.4	SOD1, GLO1, GPX1, GSTA4, GSTA3, GSTA1
12	xenobiotic metabolic process	GO:006805	10.3	CYP2J2, CYP3A5, CYP2B6, CYP2A6, CYP3A43, CYP3A4
13	induction of apoptosis by extracellular signals	GO:008624	10.3	PSEN1, PSEN2, PRKCA, SQSTM1, ADORA1, NGF
14	response to nicotine	GO:035094	10.2	SLC6A3, EDN1, NGF, HMOX1, AVP, CHRNA7
15	neutrophil chemotaxis	GO:030593	10.2	PIK3CG, IL1B, SPP1, PLA2G1B, EDN1, PRKCA
16	memory	GO:007613	10.2	NGF, TH, PSEN1, PSEN2, DBH, PTGS2
17	nerve growth factor receptor signaling pathway	GO:048011	10.2	NTRK2, CREB1, RPS27A, NGF, PSEN1, PSEN2
18	epidermal growth factor receptor signaling pathway	GO:007173	10.1	CASP9, AKT1, CREB1, RPS27A, PRKCA, CALM3
19	platelet degranulation	GO:002576	10.0	SOD1, TF, PF4, CALM3, HSPA5, ALB
20	fibroblast growth factor receptor signaling pathway	GO:008543	10.0	CASP9, AKT1, CREB1, RPS27A, PRKCA, CALM3
21	response to lipopolysaccharide	GO:032496	10.0	PTGS2, DIO2, SNCA, PLA2G4A, NGF, EDN1
22	positive regulation of angiogenesis	GO:045766	10.0	NTRK1, HIF1A, PRKCA, CX3CL1, TNFRSF1A, HMOX1
23	response to ethanol	GO:045471	9.9	TNFRSF1A, TH, PRKCA, SOD1, SLC6A3, EP300
24	negative regulation of neuron apoptotic process	GO:043524	9.8	GDNF, SOD2, SOD1, MECP2, JUN, MT3
25	aging	GO:007568	9.7	RTN4, SLC6A3, PRKCA, TSPO, PLA2G4A, CRYAB
26	positive regulation of fever generation	GO:031622	9.7	PLA2G4A, PTGS2, TNF, IL1B, CNR1
27	small molecule metabolic process	GO:044281	9.7	ODC1, HMOX1, AKT1, ETHE1, GLUL, CA4
28	neuron apoptotic process	GO:051402	9.7	PSEN1, TP53, AIFM1, CASP3, HTT, APP
29	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.6	SNCA, TNF, AKT1, GSK3B, GSK3A, AVP
30	stress-activated MAPK cascade	GO:051403	9.6	RPS27A, CRYAB, CREB1, MAPK9, MAPK1, MAPK3
31	positive regulation of smooth muscle cell proliferation	GO:048661	9.6	CX3CL1, PRKCA, STAT1, HIF1A, EDN1, PTGS2
32	response to hypoxia	GO:001666	9.4	EP300, TRH, CAMK2G, CAT, IL1B, MECP2
33	anti-apoptosis	GO:006916	9.4	GDNF, AKT1, GLO1, HSPB1, HSPA5, HTT
34	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	9.4	HMOX1, JUN, FOS, MAPK8, MAPK3, MAPK1
35	response to heat	GO:009408	9.3	SOD1, NOS1, PLA2G4A, SST, AKT1, HSPA4
36	induction of apoptosis by intracellular signals	GO:008629	9.2	AKT1, TP53, CYCS, PRKCA, CASP9, CASP3
37	angiogenesis	GO:001525	9.2	RTN4, PRKCA, HIF1A, KRIT1, CYP1B1, HMOX1
38	positive regulation of apoptotic process	GO:043065	9.2	PTGS2, PPP2R4, PLA2G4A, TSPO, SOD1, ADCY10
39	platelet activation	GO:030168	9.1	HSPA5, CALM3, AKT1, PLA2G4A, PF4, TF
40	response to drug	GO:042493	9.1	SLC6A3, CA4, MAOB, ENO2, FABP3, GRIN2A
41	activation of MAPK activity	GO:000187	9.1	SOD1, RPS27A, PLA2G1B, TNF, MAPK1, MAPK3
42	cellular response to organic substance	GO:071310	9.0	SYP, CASP3, MAP2, IL1B, BAX, BCL2
43	inflammatory response	GO:006954	9.0	TNF, TNFRSF1A, PTGS2, SPP1, NGF, PRDX5
44	blood coagulation	GO:007596	8.7	AKT1, CALM3, HSPA5, ALB, F2R, TP53
45	release of cytochrome c from mitochondria	GO:001836	8.7	SOD2, TP53, CASP3, GPX1, CCK, JUN
46	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.6	NR1H2, CREB1, PLA2G1B, NOS1, RPS27A, HIF1A
47	negative regulation of apoptotic process	GO:043066	8.6	CAT, AKT1, TP53, TNF, PF4, PRDX5
48	negative regulation of cell proliferation	GO:008285	8.1	TNF, PTGS2, SST, NTRK1, PRKCA, SOD2
49	innate immune response	GO:045087	8.1	APP, MAPK8, MAPK3, MAPK1, MAPK9, CREB1
50	apoptotic process	GO:006915	7.8	NISCH, RPS27A, CYCS, TNFRSF1A, TNF, NGF

Molecular functions related to brain disease according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	receptor binding	GO:005102	10.9	PRDX5, CX3CL1, POMC, NPY, SLC6A3, ADCYAP1
2	beta-amyloid binding	GO:001540	10.7	ACHE, HSD17B10, APOE, APOA1, APBA1, CHRNA7
3	iron ion binding	GO:005506	10.5	CYP4X1, CYP3A5, CYP2J2, NOS1, NOS2, NDOR1
4	antioxidant activity	GO:016209	10.4	PRDX5, CAT, ALB, APOE, MT3, SEPW1
5	aspartic-type endopeptidase activity	GO:004190	10.4	PSEN2, PSEN1, ERVK-6, CASP3, BACE2, BACE1
6	phosphatidylinositol 3-kinase activity	GO:035004	10.3	PIK3CG, PIK3C2A, PIK3CA, PIK3CD, PIK3CB
7	1-phosphatidylinositol-3-kinase activity	GO:016303	10.1	PIK3CG, PIK3C2A, PIK3CA, PIK3CD, PIK3CB
8	electron carrier activity	GO:009055	10.1	COX5A, CYP2J2, CYP3A5, CYP4X1, CYP2B6, CYP2A6
9	heme binding	GO:020037	10.0	CYCS, CYP4X1, CYP3A5, CYP2J2, NOS1, NOS2
10	neuropeptide hormone activity	GO:005184	9.8	NPY, HCRT, TRH, CCK, AVP, ADCYAP1
11	ubiquitin protein ligase binding	GO:031625	9.7	TF, HIF1A, SNCAIP, DIO2, TP53, HSPA5
12	copper ion binding	GO:005507	9.6	CP, SOD1, PRNP, DBH, SNCA, TP53
13	enzyme binding	GO:019899	9.4	ESR1, HMOX1, TP53, PTGS2, CYP3A4, CYP2A6
14	protein homodimerization activity	GO:042803	9.4	HMOX1, TREX1, PTGS2, NTRK1, NTRK2, PPP2R4
15	protease binding	GO:002020	8.9	POLG, CSTB, TNFRSF1A, TNF, TP53, F3
16	identical protein binding	GO:042802	8.8	AKT1, ESR1, TP53, TNF, SNCA, SYP
17	protein binding	GO:005515	6.4	HSD17B10, DMD, DISC1, DAG1, CYCS, NTRK1