MCID: BRN029
MIFTS: 57

Brain Disease malady

Neuronal diseases category

Summaries for Brain Disease

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45NINDS, 34MalaCards
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NINDS:45 Encephalopathy is a term for any diffuse disease of the brain that alters brain function or structure. Encephalopathy may be caused by infectious agent (bacteria, virus, or prion), metabolic or mitochondrial dysfunction, brain tumor or increased pressure in the skull, prolonged exposure to toxic elements (including solvents, drugs, radiation, paints, industrial chemicals, and certain metals), chronic progressive trauma, poor nutrition, or lack of oxygen or blood flow to the brain. The hallmark of encephalopathy is an altered mental state. Depending on the type and severity of encephalopathy, common neurological symptoms are progressive loss of memory and cognitive ability, subtle personality changes, inability to concentrate, lethargy, and progressive loss of consciousness. Other neurological symptoms may include myoclonus (involuntary twitching of a muscle or group of muscles), nystagmus (rapid, involuntary eye movement), tremor, muscle atrophy and weakness, dementia, seizures, and loss of ability to swallow or speak. Blood tests, spinal fluid examination, imaging studies, electroencephalograms, and similar diagnostic studies may be used to differentiate the various causes of encephalopathy.

MalaCards: Brain Disease, also known as encephalopathy, is related to myopathy and neuropathy. An important gene associated with Brain Disease is POMGNT1 (protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)), and among its related pathways are Other types of O-glycan biosynthesis and Agrin Interactions at Neuromuscular Junction. The compounds mannose and alpha-d-mannoside have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotypes are other and craniofacial.

Aliases & Classifications for Brain Disease

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Sources:
9Disease Ontology, 23GTR, 45NINDS, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain disease 9
encephalopathy 9 23 45 46
encephalopathies 63
brain diseases 63


External Ids:

Disease Ontology9 DOID:936
MeSH36 D001927
ICD1026 G93.4

Related Diseases for Brain Disease

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Brain Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 723)
idRelated DiseaseScoreTop Affiliating Genes
1myopathy30.5DAG1, DMD, SGCA, LAMB2, LAMA2, POMGNT1
2neuropathy30.2FKRP, FKTN, DAG1, DMD, SGCA, LAMB2
3congenital muscular dystrophy30.1LARGE
4mental retardation29.7FKTN, POMGNT1, CA2, FKRP, POMT1, DMD
5walker-warburg syndrome29.7FKRP, FKTN, POMT1, POMGNT1, LAMA2, LARGE
6polymyositis29.6LAMA2, DMD
7muscular dystrophy29.6POMT1, POMGNT1, LAMA2, LARGE, LAMB2, SGCA
8dilated cardiomyopathy29.6DMD, FKRP, SGCA, LAMA2
9intellectual disability29.6POMT1, FKRP, FKTN, DMD, DAG1
10congenital heart disease29.6DMD, LAMA2, FKRP
11muscular dystrophy-dystroglycanopathy , type a, 1429.4FKRP, FKTN, POMT1, POMGNT1, LAMA2, LARGE
12hypertensive encephalopathy10.9
13wernicke encephalopathy10.8
14toxic encephalopathy10.8
15creutzfeldt-jakob disease10.6
16glycine encephalopathy10.6
17scrapie10.6
18lactic acidosis10.6
19ethylmalonic encephalopathy10.6
20subcortical arteriosclerotic encephalopathy10.6
21infantile epileptic encephalopathy10.6
22muscle eye brain disease10.6
23variant creutzfeldt-jakob disease10.5
24mitochondrial neurogastrointestinal encephalopathy disease10.5
25hemorrhagic shock and encephalopathy syndrome10.5
26early myoclonic encephalopathy10.5
27status epilepticus10.4
28binswanger's disease10.4
29liver cirrhosis10.4
30familial encephalopathy with neuroserpin inclusion bodies10.4
31ohtahara syndrome10.4
32autoimmune thyroiditis10.4
33influenza10.4
34brain edema10.4
35cerebritis10.4
36cat-scratch disease10.3
37west syndrome10.3
38melas syndrome10.3
39schizophrenia10.3
40peho syndrome10.3
41dravet syndrome10.3
42optic atrophy10.3
43acute liver failure10.3
44wernicke-korsakoff syndrome10.3
45eclampsia10.3
46lennox-gastaut syndrome10.3
47kernicterus10.3
48pellagra10.3
49cortical blindness10.3
50central pontine myelinolysis10.2

Graphical network of the top 20 diseases related to Brain Disease:



Diseases related to brain disease

Symptoms for Brain Disease

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Drugs & Therapeutics for Brain Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Brain Disease

Drug clinical trials:

Search ClinicalTrials for Brain Disease

Search NIH Clinical Center for Brain Disease

Search CenterWatch for Brain Disease

Genetic Tests for Brain Disease

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Sources:
23GTR
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Genetic tests related to Brain Disease:

id Genetic test Affiliating Genes
1 Encephalopathy23

Anatomical Context for Brain Disease

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Sources:
34MalaCards
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MalaCards organs/tissues related to Brain Disease:

34
Brain, Eye, Testes, Endothelial, Lung, Liver, Heart, Cortex, Skin, Bone, Monocytes, Nk cells, T cells, Thyroid

Animal Models for Brain Disease or affiliated genes

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38MGI
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Publications for Brain Disease

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53PubMed
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Articles related to Brain Disease:

(show top 50)    (show all 410)
idTitleAuthorsYear
1
Clinical Behavior in Metastatic Brain Disease Is Not Influenced by the Immunological Defense Mediated by CD57 NK-Cells. (22312544)
2012
2
ATP-binding cassette transporters in inflammatory brain disease. (21827405)
2011
3
Calcification in major vessel beds relates to vascular brain disease. (21868705)
2011
4
Schizophrenia, brain disease and meta-analyses: integrating the pieces and testing Fusar-Poli's hypothesis. (19651477)
2010
5
Muscle-Eye-Brain disease. (20215985)
2010
6
Seizure aggravation caused by antiepileptic drugs in a patient with muscle-eye-brain disease. (20934392)
2010
7
Comment on "schizophrenia, brain disease and meta-analyses: integrating the pieces and testing Fusar-Poli's hypothesis". (19800744)
2010
8
An unusual presentation of muscle-eye-brain disease: severe eye abnormalities with mild muscle and brain involvement. (19679478)
2009
9
Schizophrenia as a progressive brain disease. (18513927)
2008
10
Efficacy and safety of risperidone in the treatment of elderly patients suffering from organic brain disease (organic brain syndrome): results from a double-blind, randomized, placebo-controlled clinical trial. (17333131)
2007
11
Muscle-eye-brain disease. Presentation of one case with genetic study]. (15954036)
2005
12
Is migraine a progressive brain disease? (14747508)
2004
13
Mutations in the FKRP gene can cause muscle-eye-brain disease and Walker-Warburg syndrome. (15121789)
2004
14
At issue: Stop the stigma: call mental illness a brain disease. (15631240)
2004
15
Neuroimaging of animal models of brain disease. (12697629)
2003
16
The role of thiamine deficiency in alcoholic brain disease. (15303623)
2003
17
Hyponatremia in acute brain disease: the cerebral salt wasting syndrome. (11836078)
2002
18
Deficiency of alpha-dystroglycan in muscle-eye-brain disease. (11883957)
2002
19
ACE gene polymorphism in patients with ischemic brain disease]. (12830537)
2001
20
A child with muscle-eye-brain disease. Ophthalmological and neurological characteristics. (11167293)
2001
21
Pharmacotherapy of disruptive behaviors associated with brain disease. (11291025)
2000
22
Neuroengineering models of brain disease. (11701524)
2000
23
The influence of the degree of cerebral atherosclerosis on the changes in hemostatic system in patients with ischemic brain disease and atherosclerotic encephalopathy. (10645149)
1999
24
The neuropsychiatry of subcortical ischemic brain disease. (11122907)
1999
25
Cerebrovascular risk factors and depression in older primary care patients: testing a vascular brain disease model of depression. (10438697)
1999
26
Increased titer of anticardiolipin antibodies represents the risk for the development of ischemic brain disease in persons below 50. (9623354)
1998
27
Two separate envelope regions influence induction of brain disease by a polytropic murine retrovirus (FMCF98). (8676516)
1996
28
Degenerative brain disease. (8813758)
1996
29
Patterns of lipid change in serum as a risk factor for ischemic brain disease]. (8114988)
1993
30
Diagnosis of enterovirus brain disease in hypogammaglobulinemic patients by polymerase chain reaction. (8268346)
1993
31
Neuronal-astrocytic interactions in brain development, brain function and brain disease. (1664174)
1991
32
Neuropathological findings in muscle-eye-brain disease (MEB-D). Neuropathological delineation of MEB-D from congenital muscular dystrophy of the Fukuyama type. (1792864)
1991
33
Some comments on the Peschels' model of biologically-based brain disease. (2377413)
1990
34
Muscle-eye-brain disease (MEB) (2360704)
1990
35
Identifying organic brain disease by amobarbital sodium interview: diagnostic pitfalls. (6758017)
1982
36
Interactive effects of age and brain disease on reaction time. (860938)
1977
37
Temporal orientation in patients with brain disease. (1211929)
1975
38
Choroid plexus papilloma mimicking degenerative brain disease in childhood. (5060466)
1972
39
Pseudodementia as initial syndrome in obscure brain disease. (5347003)
1969
40
POLYOMA-LIKE VIRIONS IN HUMAN DEMYELINATING BRAIN DISEASE. (14339302)
1965
41
HYPNOTICALLY ORIENTED PSYCHOTHERAPY IN ORGANIC BRAIN DISEASE: AN ADDENDUM. (14136314)
1964
42
Brain damage from chronic alcoholism: the diagnosis of intermediate stage of alcoholic brain disease. (13798928)
1960
43
Electroencephalographic and convulsive responses of patients with brain disease to methetharimide. (13694344)
1960
44
Early psychologic reactions associated with organic brain disease in the aged. (13632970)
1959
45
Carbohydrate metabolism in brain disease. IV. Effect of hydrocortisone and corticotropin (ACTH) on the metabolic effects of administered glucose in patients with chronic schizophrenic and manic-depressive psychoses. (13227650)
1955
46
Serial administration of the "amytal test" for brain disease; its diagnostic and prognostic value. (13123587)
1954
47
The diagnostic use of sodium amytal in organic brain disease. (13038801)
1952
48
Changes in cerebral veins in hypertensive brain disease and their relation to cerebral hemorrhage; clinical pathologic study. (21012278)
1945
49
Lectures on Paralysis as an Effect of Brain-Disease. (20748286)
1876
50
Cases of Convulsion from Organic Brain-Disease. (20747631)
1874

Variations for Brain Disease

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Expression for genes affiliated with Brain Disease

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Disease

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Pathways for genes affiliated with Brain Disease

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Sources:
51PathCards, 31KEGG, 54QIAGEN, 56Reactome, 39NCBI BioSystems Database
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Compounds for genes affiliated with Brain Disease

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46Novoseek, 52PharmGKB, 30IUPHAR, 25HMDB, 12DrugBank
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Compounds related to Brain Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mannose469.8GCNT2
2alpha-d-mannoside469.7POMGNT1, MGAT1
3acetylcholine46 52 30 25 1213.3LAMB2, DMD, DAG1
4manganese46 2510.1CA2, POMT1, POMGNT1
5creatinine468.6CA2, FKRP, LAMA2, SGCA, DMD
6heparin46 30 25 1211.5DAG1, DMD, LAMB2, LAMA2, CA2
7polysaccharide468.2DAG1, MGAT1, CA2, GCNT2
8calcium46 52 25 1211.0DAG1, DMD, LAMB2, LAMA2, POMT1, CA2

GO Terms for genes affiliated with Brain Disease

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17Gene Ontology
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Cellular components related to Brain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1costamereGO:0430349.7DAG1, DMD
2filopodiumGO:0301759.5DMD, DAG1
3basement membraneGO:0056049.5LAMA2, LAMB2, DAG1
4membrane raftGO:0451219.3SGCA, DMD, DAG1
5cytoskeletonGO:0058569.3SGCA, DMD, DAG1
6dystrophin-associated glycoprotein complexGO:0160109.2DAG1, DMD, SGCA, FKRP
7sarcolemmaGO:0423838.9FKRP, LAMA2, SGCA, DMD, DAG1
8Golgi membraneGO:0001398.3MGAT1, POMGNT1, FKTN, FKRP, GCNT2
9integral component of membraneGO:0160217.2DAG1, MGAT1, SGCA, POMGNT1, POMT1, FKTN

Biological processes related to Brain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein O-linked glycosylationGO:0064939.9POMT1, POMGNT1
2glycoprotein biosynthetic processGO:0091019.7FKRP, LARGE
3myelination in peripheral nervous systemGO:0220119.6LAMA2, DAG1
4muscle organ developmentGO:0075179.1FKTN, LAMA2, SGCA, DMD
5extracellular matrix organizationGO:0301988.7DAG1, DMD, LAMB2, LAMA2, POMT1
6protein glycosylationGO:0064868.7MGAT1, LARGE, GCNT2

Molecular functions related to Brain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dystroglycan bindingGO:0021629.9DMD, DAG1
2vinculin bindingGO:0171669.8DMD, DAG1
3structural constituent of muscleGO:0083079.8DMD, DAG1
4transferase activityGO:0167409.6FKRP, FKTN
5acetylglucosaminyltransferase activityGO:0083759.4MGAT1, LARGE

Products for genes affiliated with Brain Disease

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Sources for Brain Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet