Aliases & Classifications for Brain Edema

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Aliases & Descriptions for Brain Edema:

Name: Brain Edema 8 10 44 61
Intracranial Swelling 8
 
Cerebral Edema 61
Wet Brain 8


Classifications:



External Ids:

Disease Ontology8 DOID:4724
SNOMED-CT56 85974009, 2032001
MeSH33 D001929

Summaries for Brain Edema

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MalaCards based summary: Brain Edema, also known as intracranial swelling, is related to hepatic encephalopathy and ischemia. An important gene associated with Brain Edema is AQP4 (aquaporin 4), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Regulation of Water Balance by Renal Aquaporins. The drugs mannitol hexanitrate and mannitol and the compounds fr173657 and fr190997 have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and endothelial, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Related Diseases for Brain Edema

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Diseases related to Brain Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1hepatic encephalopathy30.8GLUL, AQP4
2ischemia30.0SOD1, AQP4, MIP, KNG1, GLUL, BDKRB2
3glioblastoma29.7AQP4, MIP, KNG1, GLUL
4astrocytoma29.4BDKRB2, GLUL, KNG1, AQP4
5cerebritis10.9
6brain injury10.9
7traumatic brain injury10.8
8acute liver failure10.7
9hepatitis10.6
10neuronitis10.6
11endotheliitis10.6
12cerebral artery occlusion10.5
13diabetes insipidus, nephrogenic10.4AQP4
14meningitis10.4
15hypoxia10.4
16diabetic cataract10.4MIP
17meniere's disease10.4MIP
18pneumococcal meningitis10.3
19middle cerebral artery infarction10.3
20intracranial hypertension10.3
21malaria10.2
22cerebral hemorrhage10.2
23diabetic ketoacidosis10.2
24benign meningioma10.2
25arteriovenous malformation10.2
26head injury10.2
27senile cataract10.2MIP, SOD1
28stroke, ischemic10.2KNG1, AQP4
29angioedema, hereditary, types i and ii10.2BDKRB2, KNG1
30hyperhomocysteinemia10.2SOD1, KNG1
31wilson disease10.2OTC, SOD1
32chronic granulomatous disease10.2SOD1, OTC
33angioedema10.1KNG1, BDKRB2
34burns10.1
35liver disease10.1
36status epilepticus10.1
37aneurysm10.1
38brain disease10.1OTC, AQP4
39wernicke-korsakoff syndrome10.1
40non-suppurative otitis media10.1KNG1, BDKRB2
41congestive heart failure10.1KNG1, MIP
42pancreatitis10.1KNG1, SOD1
43coronary artery disease10.1KNG1, SOD1
44porphyria, acute intermittent10.1SOD1, GLUL
45temporal lobe epilepsy10.0GLUL, AQP4
46reye syndrome10.0GLUL, OTC
47duchenne muscular dystrophy10.0OTC, MIP, AQP4
48vascular disease10.0OTC, KNG1, SOD1
49cataract10.0SOD1, MIP
50hyperammonemia multi-gene panels10.0OTC, GLUL

Graphical network of the top 20 diseases related to Brain Edema:



Diseases related to brain edema

Symptoms for Brain Edema

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Drugs & Therapeutics for Brain Edema

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Genetic Tests for Brain Edema

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Anatomical Context for Brain Edema

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MalaCards organs/tissues related to Brain Edema:

31
Brain, Liver, Endothelial, Lung, Breast, Prostate, Myeloid

Animal Models for Brain Edema or affiliated genes

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MGI Mouse Phenotypes related to Brain Edema:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2SOD1, AQP4, BDKRB2, OTC
2MP:00107687.7OTC, BDKRB2, GLUL, AQP4, SOD1
3MP:00053867.6SOD1, AQP4, GLUL, BDKRB2, OTC
4MP:00053767.3OTC, BDKRB2, GLUL, KNG1, AQP4, SOD1

Publications for Brain Edema

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Articles related to Brain Edema:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Asymmetric brain edema after cardiac transplantation: cerebroautoregulatory failure and relative hyperperfusion. (25645802)
2015
2
Cerebral Taurine Levels are Associated with Brain Edema and Delayed Cerebral Infarction in Patients with Aneurysmal Subarachnoid Hemorrhage. (25894453)
2015
3
Curcumin Inhibits Apoptosis and Brain Edema Induced by Hypoxia-Hypercapnia Brain Damage in Rat Models. (25867253)
2015
4
Brain edema and protein expression of c-Fos and c-Jun in the brain after diffused brain injury. (25031700)
2014
5
Brain Edema Predicts Outcome After Nonlacunar Ischemic Stroke. (25336512)
2014
6
Alleviation of brain edema and restoration of functional independence by bevacizumab in brain-metastatic breast cancer: a case report. (24944558)
2014
7
Interactions of connexin 43 and aquaporin-4 in the formation of glioma-induced brain edema. (25373717)
2014
8
Reduction of brain edema and expression of aquaporins with acute ethanol treatment after traumatic brain injury. (23198799)
2013
9
Volumetric electromagnetic phase-shift spectroscopy of brain edema and hematoma. (23691001)
2013
10
The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury. (24346689)
2013
11
Arginine vasopressin V1a receptor-deficient mice have reduced brain edema and secondary brain damage following traumatic brain injury. (23441636)
2013
12
Modern approach in therapy of brain edema in cerebral ischemia. (22926391)
2012
13
Minimally invasive procedures for evacuation of intracerebral hemorrhage reduces perihematomal glutamate content, blood-brain barrier permeability and brain edema in rabbits. (21161434)
2011
14
Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivative. (21552121)
2011
15
The influence of benzamil hydrochloride on the evolution of hyponatremic brain edema as assessed by in vivo MRI study in rats. (21445679)
2011
16
Pentoxifylline attenuates TNF-I+ protein levels and brain edema following temporary focal cerebral ischemia in rats. (21219888)
2011
17
The role of hypoxia-inducible factor-1I+, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury. (20617879)
2011
18
Diabetes aggravates nanoparticles induced breakdown of the blood-brain barrier permeability, brain edema formation, alterations in cerebral blood flow and neuronal injury. An experimental study using physiological and morphological investigations in the rat. (21121280)
2010
19
Effect of sex steroid hormones on brain edema, intracranial pressure, and neurologic outcomes after traumatic brain injury. (20555409)
2010
20
Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage. (20132873)
2010
21
Dietary virgin olive oil reduces blood brain barrier permeability, brain edema, and brain injury in rats subjected to ischemia-reperfusion. (20602077)
2010
22
Radiation exposure prior to ischemia decreases lesion volume, brain edema and cell death. (19812920)
2010
23
Brain expression of the water channels aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema. (20938728)
2010
24
Delayed enlargement of brain edema after resection of intracranial meningioma: two case reports. (19855147)
2009
25
Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline. (19220703)
2009
26
Hypothermia attenuates oxidative/nitrosative stress, encephalopathy and brain edema in acute (ischemic) liver failure. (19428816)
2009
27
Prior ethanol injection promotes brain edema after traumatic brain injury. (19558208)
2009
28
Liposome-encapsulated hemoglobin alleviates brain edema after permanent occlusion of the middle cerebral artery in rats. (19178460)
2009
29
Serum S100B, brain edema, and hematoma formation in a rat model of collagenase-induced hemorrhagic stroke. (19027832)
2009
30
Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury. (19436311)
2009
31
MR imaging-based evidence of vasogenic brain edema in a case of acute acetone intoxication. (18202235)
2008
32
Brain edema in acute liver failure: can it be prevented? Can it be treated? (17316881)
2007
33
A review of progress in understanding the pathophysiology and treatment of brain edema. (17613227)
2007
34
Matrix metalloproteinase inhibition attenuates brain edema in an in vivo model of surgically-induced brain injury. (18091283)
2007
35
Protective effect of the V1a receptor antagonist SR49059 on brain edema formation following middle cerebral artery occlusion in the rat. (16671476)
2006
36
The pathophysiology of brain edema in acute liver failure. (15961187)
2005
37
Effects of magnesium sulfate on traumatic brain edema in rats. (15294111)
2004
38
The relationship between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in intracranial meningiomas. (15662977)
2004
39
Hyperammonemia, brain edema and blood-brain barrier alterations in prehepatic portal hypertensive rats and paracetamol intoxication. (15112350)
2004
40
Brain edema -- a new classification. (12781651)
2003
41
Therapeutical efficacy of a novel non-peptide bradykinin B2 receptor antagonist on brain edema formation and ischemic tissue damage in focal cerebral ischemia. (14753436)
2003
42
Antioxidant compounds EGB-761 and BN-52021 attenuate brain edema formation and hemeoxygenase expression following hyperthermic brain injury in the rat. (14753460)
2003
43
Long-term hypothermia in patients with severe brain edema after poor-grade subarachnoid hemorrhage: feasibility and intensive care complications. (12826972)
2003
44
Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. (15344903)
2003
45
Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist. (11596963)
2001
46
The effect of treatment with albumin, hetastarch, or hypertonic saline on neurological status and brain edema in a rat model of closed head trauma combined with uncontrolled hemorrhage and concurrent resuscitation in rats. (11226099)
2001
47
ONTARIO. Congenital brain edema in 2 Hereford calves. (17424613)
2000
48
Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. (10701532)
2000
49
The synergistic effect of acute subdural hematoma combined with diffuse traumatic brain injury on brain edema. (11450010)
2000
50
Role of hydrodynamic processes in the pathogenesis of peritumoral brain edema in meningiomas. (11014537)
2000

Variations for Brain Edema

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Expression for genes affiliated with Brain Edema

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Search GEO for disease gene expression data for Brain Edema.

Pathways for genes affiliated with Brain Edema

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Pathways related to Brain Edema according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6KNG1, SOD1
2
Show member pathways
9.6MIP, AQP4
3
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.4KNG1, BDKRB2
4
Show member pathways
9.4BDKRB2, KNG1
5
Show member pathways
citrulline-nitric oxide cycle36
arginine degradation I (arginase pathway)36
proline degradation36
glutamine degradation I36
proline biosynthesis I36
superpathway of citrulline metabolism36
proline biosynthesis II (from arginine)36
citrulline biosynthesis36
arginine degradation VI (arginase 2 pathway)36
Urea cycle and metabolism of amino groups36
asparagine biosynthesis I36
4-hydroxyproline degradation I36
citrulline degradation36
9.1OTC, GLUL

Compounds for genes affiliated with Brain Edema

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Compounds related to Brain Edema according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1fr17365744 2810.9KNG1, BDKRB2
2fr19099744 2810.9KNG1, BDKRB2
3cereport449.9KNG1, BDKRB2
4lys-[des-arg9]bradykinin609.9KNG1, BDKRB2
5win 64338 hydrochloride609.9BDKRB2, KNG1
6benzoate449.9SOD1, OTC
7r 715609.9KNG1, BDKRB2
8hoe 140609.8KNG1, BDKRB2
9quinaprilat449.8KNG1, BDKRB2
10mercury449.8AQP4, MIP
11des-arg(10)-kallidin449.8BDKRB2, KNG1
12ramiprilat449.8BDKRB2, KNG1
13icatibant44 28 1111.8BDKRB2, KNG1
14kallidin44 2810.8KNG1, BDKRB2
15bradykinin60 28 2411.8BDKRB2, KNG1
16enalaprilat449.8BDKRB2, KNG1
17mepyramine44 1110.7KNG1, BDKRB2
18lisinopril44 50 24 1112.7BDKRB2, KNG1
19nitroglycerin44 1110.7KNG1, SOD1
20allopurinol44 50 1111.7SOD1, OTC
21candesartan44 50 28 1112.6KNG1, BDKRB2
22citrulline44 2410.5SOD1, OTC, KNG1
23mannitol44 1110.5SOD1, AQP4, MIP
24captopril44 60 50 28 1113.4KNG1, BDKRB2
25tetraethylammonium44 28 1111.4KNG1, MIP
26n(g)-nitro-l-arginine methyl ester449.4SOD1, KNG1, BDKRB2
27ng-nitro-l-arginine449.4BDKRB2, SOD1, KNG1
28l-nmma449.4BDKRB2, KNG1, SOD1
29carbamoyl phosphate449.4GLUL, OTC
30sodium nitroprusside449.3BDKRB2, SOD1, KNG1
31potassium44 24 1111.3MIP, KNG1, AQP4
32histamine44 28 2411.2BDKRB2, KNG1, AQP4
33indomethacin44 28 60 1112.2BDKRB2, KNG1, SOD1
34phosphoenolpyruvate44 1110.1GLUL, OTC
35ammonium449.0GLUL, OTC, MIP
36chloride449.0AQP4, GLUL, MIP
37malate448.8OTC, GLUL
38urea44 24 1110.7AQP4, GLUL, OTC, MIP
39glycerol44 24 1110.7OTC, GLUL, MIP, AQP4
40proline448.6BDKRB2, GLUL, MIP
41lactate448.5OTC, SOD1, MIP, GLUL
42dexamethasone44 50 28 1111.4GLUL, MIP, BDKRB2, AQP4
43creatinine448.4SOD1, GLUL, BDKRB2, OTC
44cysteine448.1SOD1, AQP4, MIP, GLUL, BDKRB2
45atp44 289.0KNG1, OTC, BDKRB2, GLUL, MIP
46lipid447.9MIP, OTC, GLUL, BDKRB2, SOD1
47sodium44 248.7OTC, KNG1, AQP4, MIP, GLUL, BDKRB2
48glutamate447.6BDKRB2, SOD1, AQP4, MIP, GLUL, OTC
49arginine447.6OTC, KNG1, BDKRB2, SOD1, MIP, GLUL
50nitric oxide44 24 119.6BDKRB2, SOD1, KNG1, MIP, OTC, GLUL

GO Terms for genes affiliated with Brain Edema

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Cellular components related to Brain Edema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:00432348.5GLUL, AQP4, SOD1
2plasma membraneGO:00058868.1BDKRB2, KNG1, MIP, AQP4, SOD1

Biological processes related to Brain Edema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1vasodilationGO:00423119.5BDKRB2, KNG1
2water transportGO:00068339.5AQP4, MIP
3smooth muscle contractionGO:00069399.4BDKRB2, KNG1
4positive regulation of cytosolic calcium ion concentrationGO:00072049.4BDKRB2, KNG1
5platelet degranulationGO:00025769.3KNG1, SOD1

Sources for Brain Edema

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet