Brain Edema malady

Wikipedia: Cerebral edema or cerebral œdema is an excess accumulation of water in the intracellular or...⁴⁴ more...

MalaCards: Brain Edema, also known as intracranial swelling, is related to acute liver failure and diabetic ketoacidosis. An important gene associated with Brain Edema is AQP4 (aquaporin 4), and among its related pathways are Passive Transport by Aquaporins and G alpha (i) signalling events. The drugs mannitol hexanitrate and dexamethasone phosphate and the compounds nitroglycerin and glucose have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and b cells, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Descriptions:

brain edema 6 8 32 43 intracranial swelling 6

wet brain 6

Diseases related to brain edema by text searches and GeneDecks gene sharing:

(show top 50)    (show all 641)

id	Related Disease	Score	Top Affiliating Genes
1	acute liver failure	31.1	ALB, OTC, TSPO, SLC1A2
2	diabetic ketoacidosis	28.2	CLDN5, IL6, ALB, SST, CRP, AGER
3	cerebral artery occlusion	27.2	VEGFA, CLDN5, PARP1, MMP9, IL1RN, AQP4
4	meningioma	26.2	VEGFA, MMP9, IL6, AQP1, AQP4, GLUL
5	cerebral infarction	23.2	SERPINE2, VEGFA, MMP9, IL1B, IL1RN, IL6
6	neurodegeneration	22.7	SERPINE2, VEGFA, PARP1, MMP9, IL1B, IL1RN
7	sinusitis	22.4	VEGFA, CLDN5, MMP9, IL1B, IL1RN, IL6
8	brain injury	21.9	VEGFA, PARP1, BDKRB2, MMP9, MIP, IL1B
9	thrombosis	21.4	VEGFA, MMP9, IL1B, IL1RN, IL6, ALB
10	cerebritis	20.8	SERPINE2, VEGFA, CLDN5, PARP1, BDKRB2, MMP9
11	ischemia	19.8	VEGFA, CLDN5, PARP1, BDKRB2, MMP9, MIP
12	neuronitis	18.4	SERPINE2, VEGFA, PARP1, BDKRB2, KCNJ10, MMP9
13	hyperammonemia with hypoornithinemia	13.6	GLUL, OTC, TSPO, SLC25A13
14	sleep apnea	13.6	TSPO, NPPB, KNG1
15	diabetic cataract	13.6	MIP, CAT, SOD1
16	acute intermittent porphyria	13.6	GLUL, HMOX1, SOD1
17	meningitis and encephalitis	13.5	CAT, CRP, SOD1
18	chronic granulomatous disease	13.5	CAT, OTC, TSPO, SOD1
19	renal hypertension	13.5	ALB, EDN1, KNG1
20	galactosemia	13.5	MIP, ALB, GLUL, TSPO
21	senile cataract	13.5	MIP, ALB, CAT, SOD1
22	temporal lobe epilepsy	13.4	AQP4, GLUL, GFAP, TSPO, SLC1A2
23	glycogen storage disease type ia	13.4	CAT, CRP, SOD1
24	protein-losing enteropathy	13.4	ALB, OXA1L
25	diabetic angiopathy	13.4	CAT, EDN1, AGER
26	status epilepticus	13.4	OTC, GFAP, TSPO, SLC25A13
27	maple syrup urine disease	13.4	ALB, CAT, OTC, GFAP, SOD1
28	polyhydramnios	13.4	AQP1, AQP9, EDN1, NPPB
29	myocardial stunning	13.4	CAT, EDN1, SOD1
30	aseptic meningitis	13.3	IL1B, CAT, SOD1
31	abcb11-related intrahepatic cholestasis	13.3	MIP, NPPA, NPPB, KNG1
32	cryptosporidiosis	13.3	CAT, DHFR, CSF3
33	gastric cancer risk after h. pylori infection	13.3	IL1B, IL1RN
34	intracranial hypertension	13.3	IL1B, AQP4, ALB
35	aicardi-goutieres syndrome	13.3	AQP4, ALB, OTC, TSPO, SLC25A13, CPT2
36	bronchitis	13.2	PARP1, BDKRB2, AGER, KNG1
37	somatoform disorder	13.2	IL1B, IL1RN, TSPO
38	meningococcemia	13.2	IL1B, IL1RN, PROC
39	short limb dwarf edema iris coloboma	13.2	ALB, NPPA, NPPB
40	viral pneumonia	13.2	IL6, ALB, CRP
41	optic neuritis	13.2	MMP9, AQP4, CAT, GFAP
42	avascular necrosis of femoral head	13.2	VEGFA, CAT, SOD1
43	capillary leak syndrome	13.2	IL6, ALB, CSF3
44	acrodermatitis	13.2	IL1B, ALB, OTC
45	hypomagnesemia	13.2	KCNJ10, ALB, CRP
46	x-linked magnesium deficiency with epstein-barr virus infection and neoplasia	13.2	ALB, CAT, EDN1
47	duchenne muscular dystrophy	13.2	MIP, AQP4, OTC, NPPA, NPPB
48	renal vascular disease	13.2	VEGFA, ALB, AGER
49	nephrosis	13.2	IL6, ALB, TJP1, SOD1, KNG1
50	plasminogen activator inhibitor type 1 deficiency	13.2	PLAT, KNG1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], mannitol, mannitol hexanitrate, mannitol pwdr [va product]

MalaCards organs/tissues related to brain edema:

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MGI Mouse Phenotypes related to brain edema:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.9	RICTOR, TSC22D3, OTC, AQP1, BDKRB2, SERPINE2
2	renal/urinary system phenotype	MP:0005367	9.7	RICTOR, SLC25A13, NPPA, OTC, AQP4, AQP1
3	hematopoietic system phenotype	MP:0005397	9.7	RICTOR, SLC7A11, CSF3, OTC, AQP9, AQP1
4	liver/biliary system phenotype	MP:0005370	9.3	SLC25A13, SOD1, OTC, IL6, VEGFA, RICTOR
5	reproductive system phenotype	MP:0005389	8.6	RICTOR, OCLN, OTC, IL6, IL1RN, MMP9
6	nervous system phenotype	MP:0003631	8.3	EDN1, PROC, OCLN, SLC5A7, SLC1A2, PLAU
7	immune system phenotype	MP:0005387	8.2	GFAP, PROC, OCLN, SLC7A11, RICTOR, AGER
8	skeleton phenotype	MP:0005390	7.8	RICTOR, PLAU, PLAT, ANXA1, IL6, MMP9
9	hearing/vestibular/ear phenotype	MP:0005377	7.6	SOD1, EDN1, PLAU, PLAT, AQP4, AQP1
10	vision/eye phenotype	MP:0005391	7.4	PLAT, PLAU, GFAP, SOD1, AQP4, AQP1
11	digestive/alimentary phenotype	MP:0005381	7.2	OCLN, GFAP, EDN1, PLAU, PLAT, SST
12	behavior/neurological phenotype	MP:0005386	7.1	PLAT, AGER, GFAP, PROC, OCLN, SLC5A7
13	growth/size phenotype	MP:0005378	6.8	PLAT, PLAU, AGER, GFAP, OCLN, SLC1A2
14	muscle phenotype	MP:0005369	5.7	PROC, OCLN, SOD1, NPPA, NPPB, RICTOR
15	cellular phenotype	MP:0005384	5.3	PLAT, PLAU, AGER, GFAP, TSC22D3, SOD1
16	mortality/aging	MP:0010768	5.0	OTC, PLAT, PLAU, EDN1, GFAP, PROC
17	cardiovascular system phenotype	MP:0005385	4.5	PLAT, PLAU, EDN1, AGER, GFAP, PROC
18	homeostasis/metabolism phenotype	MP:0005376	2.7	KNG1, SST, CRP, PLAT, PLAU, EDN1

Articles related to brain edema:

(show top 50)    (show all 55)

id	Title	Authors	Year	Affiliating Genes
1	Influence of interleukin-6 on the development of peri tumoral brain edema in meningiomas. (19445568)	Park K.J.... Chung Y.G.	2010	IL6
2	Ammonia and proinflammatory cytokines modify expressi on of genes coding for astrocytic proteins implicated in brain edema in acute l iver failure. (20217200)	Chastre A.... Butterworth R.F.	2010	HMOX1, AQP4
3	Protective effect of albumin on VEGF and brain edema in acute ischemia in rats. (20138968)	Yao X.... Feng H.	2010	VEGFA
4	Aquaporin-4 and traumatic brain edema. (20356447)	Xu M.... Xu Q.P.	2010	AQP4
5	Roles of inflammation and the activated protein C pat hway in the brain edema associated with cerebral venous sinus thrombosis. (19892996)	Nagai M.... Granger D.N.	2010	PROC
6	Role of bradykinin and catecholamines in cerebral infarction and brain edema. (19265042)	Tsuda K.	2009	KNG1
7	Inflammatory mediators and blood brain barrier disruption in fatal brain edema of diabetic ketoacidosis. (19103180)	Hoffman W.H.... Andjelkovic A.V.	2009	CLDN5
8	Delayed enlargement of brain edema after resection of intracranial meningioma: two case reports. (19855147)	Ono K.... Wada K.	2009	VEGFA
9	AQP4 expression in the brains of patients with gliob lastoma and its association with brain edema (19764565)	Mou K.J.... Liu Y.H.	2009	AQP4
10	The expression and the role of protease nexin-1 on brain edema after intracerebral hemorrhage. (18442833)	Wu H.... Huang Q.	2008	AQP4, SERPINE2
11	The relationship between the aquaporin-4 and brain edema, pathologic change, ultrastructure in perihematoma tissue in patients with intracerebral hemorrhage. (19000426)	Guo F.Q.... Yang G.	2008	AQP4
12	Plasmatic B-type natriuretic peptide and C-reactive protein in hyperacute stroke as markers of CT-evidence of brain edema. (18219371)	Modrego P.J.... Serrano M.	2008	CRP, NPPB
13	Receptor for advanced glycation end products and neuronal deficit in the fatal brain edema of diabetic ketoacidosis. (18775683)	Hoffman W.H.... Sima A.A.	2008	AGER
14	The role of aquaporin-4 polymorphisms in the development of brain edema after middle cerebral artery occlusion. (18309154)	Kleffner I.... Kuhlenbaumer G.	2008	AQP4
15	Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema. (18469825)	Savaskan N.E.... Eyupoglu I.Y.	2008	SLC7A11
16	A review of progress in understanding the pathophysiology and treatment of brain edema. (17613227)	Marmarou A.	2007	MIP
17	Delivery of anti-platelet-endothelial cell adhesion molecule single-chain variable fragment-urokinase fusion protein to the cerebral vasculature lyses arterial clots and attenuates postischemic brain edema. (17389242)	Danielyan K.... Muzykantov V.R.	2007	PLAU
18	Can variation in aquaporin 4 gene be associated with different outcomes in traumatic brain edema? (17890008)	Romeiro R.R.... Correa H.	2007	AQP4
19	Astrocytes co-express aquaporin-1, -4, and vascular endothelial growth factor in brain edema tissue associated with brain contusion. (16671493)	Suzuki R.... Suzuki T.	2006	AQP1, MIP
20	Granulocyte colony-stimulating factor does not affect contusion size, brain edema or cerebrospinal fluid glutamate concentrations in rats following controlled cortical impact. (16671442)	Sakowitz O.W.... Kiening K.L.	2006	CSF3
21	Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure. (15826719)	BAclanger M.... Butterworth R.F.	2005	TSPO
22	Brain edema and aquaporin (16313100)	Yamada K.	2005	AQP1, AQP4, MIP
23	Intraventricular albumin: an optional agent in experimental post-traumatic brain edema. (15829162)	Is M.... Kilic N.	2005	ALB
24	Importance of aquaporins in the physiopathology of brain edema. (15281891)	Venero J.L.... Cano J.	2004	AQP4, MIP
25	Focal brain edema and natriuretic peptides in patients with subarachnoid hemorrhage. (15177394)	Fukui S.... Shima K.	2004	NPPB, NPPA
26	Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. (14734638)	Amiry-Moghaddam M.... Ottersen O.P.	2004	AQP4
27	Aquaporins and brain edema. (15120208)	Griesdale D.E.... Honey C.R.	2004	MIP
28	Pathophysiology of traumatic brain edema: current concepts. (14753394)	Marmarou A.	2003	MIP
29	Brain edema in acute liver failure. (15025258)	Butterworth R.F.	2003	SLC1A2
30	Poly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia: its role in brain edema and cell death. (12663936)	Strosznajder R.P.... Strosznajder J.B.	2003	PARP1
31	Overexpression of interleukin-1 receptor antagonist reduces brain edema induced by intracerebral hemorrhage and thrombin. (14753487)	Masada T.... Nagao S.	2003	IL1RN
32	Therapeutical efficacy of a novel non-peptide bradykinin B2 receptor antagonist on brain edema formation and ischemic tissue damage in focal cerebral ischemia. (14753436)	Zausinger S.... Baethmann A.	2003	KNG1, BDKRB2
33	Relationship between aquaporin-4 expression in astrocytes and brain edema caused by glioma (12810377)	Chen Y.Z.... Cai Y.Q.	2003	AQP4
34	The role of somatostatin in vasogenic meningioma asso ciated brain edema. (12841659)	Pistolesi S.... Parenti G.	2003	VEGFA, SST
35	Bench to bedside: brain edema and cerebral resuscitation: the present and future. (12208684)	Xiao F.	2002	AQP4
36	Pathophysiology of brain edema formation. (12486926)	Xi G.... Hoff J.T.	2002	PLAT
37	Effect of baicalin and dexamethasone on cytokines in brain tissue of infectious brain edema (12516391)	Yu Y.... Tao Y.G.	2000	IL1B
38	Vascular endothelial factor of meningomas and peritumoural vasogenic brain edema (11831981)	Zhang Z.... Zhu X.	2000	VEGFA
39	LF16-0687 a novel non-peptide bradykinin B2 receptor antagonist reduces vasogenic brain edema from a focal lesion in rats. (11449993)	Schulz J.... Baethmann A.	2000	KNG1
40	Lipocortin-1 fails to ameliorate cold-injury brain edema in the rat. (11450032)	Mima T.... Shigeno T.	2000	ANXA1
41	Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: potential role in brain edema. (10448052)	Vizuete M.L.... Cano J.	1999	AQP4
42	L-ornithine-L-aspartate lowers plasma and cerebrospin al fluid ammonia and prevents brain edema in rats with acute liver failure. (10462368)	Rose C.... Butterworth R.F.	1999	GLUL
43	Albumin or hetastarch improves neurological outcome and decreases volume of brain tissue necrosis but not brain edema following closed-head trauma in rats. (10527147)	Chorny I.... Shapira Y.	1999	ALB, OXA1L
44	Peritumoral brain edema associated with meningioma: i nfluence of vascular endothelial growth factor expression and vascular blood su pply. (10091773)	Yoshioka H.... Kurisu K.	1999	VEGFA
45	Brain edema: pathogenesis and therapy. (9185109)	Schilling L.... Wahl M.	1997	KNG1
46	Effect of delayed albumin hemodilution on infarction volume and brain edema after transient middle cerebral artery occlusion in rats. (9322848)	Belayev L.... Ginsberg M.D.	1997	OXA1L
47	Cytoxicity of [(5,6-dichloro-9a-n-propyl-2,3,9,9a-tetrahydro-3-oxo-1H fluoren-7-yl)oxy]acetic acid, an agent known to reduce brain edema. (8672727)	Hall I.H.... Wyrick S.D.	1996	DHFR
48	High colloid oncotic therapy for brain edema with cer ebral hemorrhage. (7976652)	Tone O.... Tominaga B.	1994	ALB
49	Histochemical demonstration of free radicals (H2O2) in ischemic brain edema and protective effects of human recombinant superoxide dismutase on ischemic neuronal damage. (7976574)	Morooka H.... Ohmoto T.	1994	SOD1, CAT
50	The effect of the delta sleep-inducing peptide on th e development of toxic brain edema-swelling (1290809)	Platonov I.A.... Iasnetsov V.V.	1992	TSC22D3

Genes related to brain edema according to GeneCards:

(show all 47)

id	Symbol	Description	Score	GeneCards Section Context
1	AQP4	aquaporin 4	11.0	Publications
2	KNG1	kininogen 1	11.0	Publications
3	SOD1	superoxide dismutase 1, soluble	11.0	Publications
4	MIP	major intrinsic protein of lens fiber	11.0	Publications
5	OXA1L	oxidase (cytochrome c) assembly 1-like	11.0	Publications
6	OTC	ornithine carbamoyltransferase	11.0	Publications
7	GLUL	glutamate-ammonia ligase	11.0	Publications
8	BDKRB2	bradykinin receptor B2	11.0	Publications
9	ANXA1	annexin A1	11.0	Publications
10	SLC25A13	solute carrier family 25 (aspartate/glutamate carrier), member 13	11.0
11	GFAP	glial fibrillary acidic protein	11.0
12	CLDN5	claudin 5	11.0	Publications
13	AQP1	aquaporin 1 (Colton blood group)	11.0	Publications
14	TSC22D3	TSC22 domain family, member 3	11.0	Publications
15	SLC7A11	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	11.0	Publications
16	SLC5A7	solute carrier family 5 (choline transporter), member 7	11.0
17	KCNJ10	potassium inwardly-rectifying channel, subfamily J, member 10	11.0
18	AQP9	aquaporin 9	11.0
19	TSPO	translocator protein (18kDa)	11.0	Publications
20	OCLN	occludin	11.0
21	SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	11.0	Publications
22	PROC	protein C (inactivator of coagulation factors Va and VIIIa)	11.0	Publications
23	FAM176A	family with sequence similarity 176, member A	11.0	Disorders
24	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
25	CPT2	carnitine palmitoyltransferase 2	11.0
26	RICTOR	RPTOR independent companion of MTOR, complex 2	11.0
27	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11.0	Publications
28	DHFR	dihydrofolate reductase	11.0	Publications
29	NPPB	natriuretic peptide B	11.0	Publications
30	TJP1	tight junction protein 1	11.0
31	TJP2	tight junction protein 2	11.0
32	SST	somatostatin	11.0	Publications
33	VEGFA	vascular endothelial growth factor A	11.0	Publications
34	PARP1	poly (ADP-ribose) polymerase 1	11.0	Publications
35	ALB	albumin	11.0	Publications
36	CRP	C-reactive protein, pentraxin-related	11.0	Publications
37	CAT	catalase	11.0	Publications
38	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
39	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
40	IL1B	interleukin 1, beta	11.0	Publications
41	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0
42	NPPA	natriuretic peptide A	11.0	Publications
43	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
44	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
45	EDN1	endothelin 1	11.0	Publications
46	PLAT	plasminogen activator, tissue	11.0	Publications
47	PLAU	plasminogen activator, urokinase	11.0	Publications

Pathways related to brain edema according to GeneDecks:

(show all 11)

id	Pathway	Score	Top Affiliating Genes
1	Passive Transport by Aquaporins38	10.3	MIP, AQP1, AQP4, AQP9
2	G alpha (i) signalling events38	10.2	BDKRB2, ANXA1, KNG1
3	Cell adhesion_Endothelial cell contacts by junctional mechanisms41	10.0	OCLN, TJP2, TJP1, CLDN5
4	Cell adhesion_Tight junctions41	9.5	CLDN5, TJP1, TJP2, OCLN
5	Selected targets of GCR-alpha10	9.4	GLUL, AQP9, IL6, IL1B
6	Blood Coagulation Signaling Pathways37	9.1	PLAT, PLAU, PROC, KNG1
7	Complement and coagulation cascades20	9.0	KNG1, PROC, PLAU, PLAT, BDKRB2
8	Immune response IL-1 signaling pathway10	8.7	EDN1, HMOX1, IL6, IL1B
9	Cell adhesion_ECM remodeling41	8.7	PLAU, PLAT, MMP9, SERPINE2
10	Immune response_IL-1 signaling pathway41	8.6	EDN1, HMOX1, IL6, IL1B
11	Cell adhesion ECM remodeling10	8.6	PLAU, PLAT, MMP9, SERPINE2

Compounds related to brain edema according to GeneDecks:

(show top 50)    (show all 273)

id	Compound	Score	Top Affiliating Genes
1	nitroglycerin32 9 9	12.6	SST
2	glucose32	10.0	OTC, MIP, AQP1, AQP9, TJP1, SLC5A7
3	n acetylcysteine32	9.8	MMP9, PLAU, AGER
4	captopril32 42 9 9	12.7	BDKRB2, KNG1, NPPB, NPPA, ALB
5	candesartan32 9 9	11.6	BDKRB2, VEGFA, ALB, AGER, NPPB, KNG1
6	lisinopril32 9 18 9	12.5	VEGFA, BDKRB2, ALB, NPPA, NPPB, KNG1
7	h2o232	9.5	IL1RN, GLUL, TJP1, TSPO, DHFR, OXA1L
8	mannitol32 9 9	11.5	SOD1, TJP1, CAT, AQP9, AQP1, NPPA
9	bucillamine32	9.1	CRP, VEGFA, IL1B, IL6, CAT
10	sodium nitroprusside32	9.1	BDKRB2, CAT, HMOX1, SST, NPPA, NPPB
11	oxygen32 18	10.0	SLC1A2, MIP, GLUL, ANXA1, PARP1, AGER
12	fosinopril32 9 9	11.0	NPPB, CRP, NPPA, MMP9, ALB
13	l-nmma32	8.8	SOD1, NPPA, NPPB, KNG1, EDN1, CAT
14	pdtc32	8.8	IL6, SOD1, HMOX1, PARP1, MMP9, CAT
15	glycerol32 9 18 9	11.8	SLC25A13, NPPA, DHFR, TSPO, OTC, GLUL
16	sodium32 18	9.7	KNG1, SLC7A11, NPPB, SLC5A7, SLC1A2, BDKRB2
17	perindopril32 34 9 9	11.6	VEGFA, KNG1, PLAT, ALB, NPPA, CRP
18	enalaprilat32	8.6	KNG1, BDKRB2, PLAT, EDN1, NPPA, NPPB
19	arsenite32 18	9.4	PARP1, MMP9, MIP, CAT, HMOX1, TSPO
20	omapatrilat32	8.3	KNG1, NPPA, MMP9, EDN1, PLAT
21	enalapril32 9 9	10.2	ALB, PLAT, NPPA, NPPB, KNG1, EDN1
22	pge232	8.2	HMOX1, KNG1, NPPB, EDN1, PLAU, SST
23	quinapril32 9 9	10.2	PLAT, CRP, KNG1, EDN1, NPPA
24	s-nitroso-n-acetylpenicillamine32	8.2	EDN1, SOD1, CAT, NPPA, PARP1, HMOX1
25	gabexate mesilate32	8.1	PLAU, PLAT, CRP, SST, IL6, MMP9
26	8-isoprostane32	8.1	EDN1, CAT, CRP, NPPB, SOD1, HMOX1
27	nitric oxide32 9 18 9	11.0	AQP1, ANXA1, TJP1, IL1RN, IL1B, MIP
28	losartan32 34 9 9	11.0	PLAT, NPPB, CRP, EDN1, NPPA, KNG1
29	nifedipine32 9 9	10.0	KNG1, SST, MMP9, NPPA, AGER, EDN1
30	calcium32 9 18 9	10.9	SLC1A2, AGER, AQP1, ALB, NPPB, GLUL
31	hydrocortisone32 9 9	9.9	TJP1, ANXA1, PLAU, SST, GLUL, IL1RN
32	glutamate32	7.8	PLAU, SLC1A2, GFAP, BDKRB2, PLAT, SST
33	arginine32	7.7	SLC1A2, BDKRB2, MIP, SST, GLUL, HMOX1
34	creatinine32	7.7	BDKRB2, MMP9, IL1RN, AQP1, GLUL, CPT2
35	curcumin32	7.5	CAT, HMOX1, TJP1, OXA1L, IL6, IL1B
36	adenylate32	7.4	PLAT, MMP9, IL1RN, ANXA1, GLUL, SST
37	sb 20358032 42	8.4	NPPB, PLAU, CRP, HMOX1, MMP9, EDN1
38	lipid32	7.3	SOD1, TSC22D3, ALB, MIP, AQP1, BDKRB2
39	genistein32 9 18 9	10.1	PLAU, TJP1, SST, IL6, MMP9, BDKRB2
40	norepinephrine32 9 18 9	9.9	EDN1, MMP9, TSC22D3, TSPO, SST, IL1RN
41	cysteine32	6.7	SLC1A2, SLC7A11, NPPB, OXA1L, DHFR, GFAP
42	dexamethasone32 42 34 9 9	10.7	AQP1, IL6, IL1RN, VEGFA, PARP1, BDKRB2
43	prostacyclin32	6.6	HMOX1, SOD1, NPPA, EDN1, AGER, NPPB
44	atorvastatin32 34 9 18 9	10.5	PLAT, CRP, HMOX1, IL6, IL1RN, MMP9
45	lactate32	6.3	SLC1A2, MIP, NPPB, SOD1, DHFR, GFAP
46	histamine32 18	7.0	BDKRB2, IL1B, KNG1, NPPB, TSPO, EDN1
47	indomethacin32 9 9	8.0	KNG1, NPPB, SOD1, TSPO, EDN1, PLAU
48	actinomycin d32	6.0	VEGFA, HMOX1, PLAT, PLAU, EDN1, NPPB
49	vegf32	5.1	BDKRB2, MMP9, MIP, IL1B, IL1RN, IL6
50	cycloheximide32	4.7	SERPINE2, KNG1, CSF3, GFAP, VEGFA, PARP1

Cellular components related to brain edema according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	basolateral plasma membrane	GO:016323	9.4	TJP1, ANXA1, AQP9, AQP4, AQP1, KCNJ10
2	plasma membrane	GO:005886	7.1	PLAU, AGER, PROC, OCLN, SOD1, SLC5A7
3	extracellular region	GO:005576	4.9	PLAU, EDN1, AGER, PROC, SOD1, NPPA
4	extracellular space	GO:005615	4.6	VEGFA, KNG1, NPPB, CSF3, SOD1, PROC

Biological processes related to brain edema according to GeneDecks:

(show all 29)

id	Name	GO ID	Score	Top Affiliating Genes
1	multicellular organismal water homeostasis	GO:050891	10.4	AQP4, AQP1
2	water transport	GO:006833	10.4	AQP9, AQP4, AQP1, MIP
3	canalicular bile acid transport	GO:015722	10.3	AQP9, MIP
4	cGMP biosynthetic process	GO:006182	10.1	AQP1, NPPA, NPPB
5	cellular response to hydrogen peroxide	GO:070301	10.0	ANXA1, AQP1, IL6
6	embryo implantation	GO:007566	9.9	SOD1, IL1B, MMP9, SERPINE2
7	negative regulation of blood coagulation	GO:030195	9.9	KNG1, PROC, EDN1, SERPINE2
8	positive regulation of renal sodium excretion	GO:035815	9.8	KNG1, NPPB, EDN1
9	body fluid secretion	GO:007589	9.8	EDN1, TSC22D3, NPPB
10	positive regulation of urine volume	GO:035810	9.8	KNG1, NPPB, EDN1
11	platelet degranulation	GO:002576	9.8	VEGFA, ALB, SOD1, KNG1
12	nitric oxide transport	GO:030185	9.8	EDN1, AQP1
13	response to testosterone stimulus	GO:033574	9.8	EDN1, TSPO, OCLN
14	cellular response to hypoxia	GO:071456	9.7	HMOX1, AQP1, BDKRB2, VEGFA
15	chronic inflammatory response to antigenic stimulus	GO:002439	9.7	IL1RN, IL1B
16	response to heat	GO:009408	9.7	MMP9, IL1B, SST, SOD1
17	positive regulation of apoptotic process	GO:043065	9.6	KNG1, SOD1, TSPO, ANXA1, IL1B, MMP9
18	regulation of blood pressure	GO:008217	9.5	NPPB, NPPA, SOD1, HMOX1
19	cell surface receptor signaling pathway	GO:007166	9.4	NPPB, AGER, EDN1, SST, ANXA1, BDKRB2
20	positive regulation of angiogenesis	GO:045766	9.2	HMOX1, AQP1, IL1B, MMP9, VEGFA
21	transmembrane transport	GO:055085	9.2	SLC1A2, SLC7A11, SLC5A7, HMOX1, ALB, AQP9
22	response to nicotine	GO:035094	9.2	SLC7A11, EDN1, HMOX1, MMP9
23	inflammatory response	GO:006954	9.0	KNG1, NPPB, AGER, CRP, ANXA1, IL6
24	negative regulation of apoptotic process	GO:043066	8.9	PROC, CAT, ALB, AQP1, IL6, IL1RN
25	positive regulation of JUN kinase activity	GO:043507	8.9	EDN1, IL1RN, IL1B
26	response to glucocorticoid stimulus	GO:051384	8.7	PLAT, IL6, IL1RN, IL1B, KCNJ10
27	response to drug	GO:042493	8.5	BDKRB2, NPPB, SOD1, TSPO, EDN1, SST
28	blood coagulation	GO:007596	8.4	KNG1, SLC7A11, SOD1, PROC, PLAU, PLAT
29	response to hypoxia	GO:001666	7.7	NPPB, EDN1, PLAT, CRP, CAT, IL1B

Molecular functions related to brain edema according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	water transmembrane transporter activity	GO:005372	10.2	AQP1, AQP4, AQP9
2	water channel activity	GO:015250	10.0	MIP, AQP1, AQP9
3	receptor binding	GO:005102	9.3	SERPINE2, ANXA1, CAT, NPPA, NPPB, KNG1
4	cytokine activity	GO:005125	8.2	CSF3, EDN1, IL6, IL1B, VEGFA