Aliases & Classifications for Brain Edema

MalaCards integrated aliases for Brain Edema:

Name: Brain Edema 12 51 41 14 69
Cerebral Edema 69 28
Intracranial Swelling 12
Wet Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4724
MeSH 41 D001929
SNOMED-CT 64 2032001 85974009

Summaries for Brain Edema

MalaCards based summary : Brain Edema, also known as cerebral edema, is related to hydrops, lactic acidosis, and sideroblastic anemia and pneumococcal meningitis, and has symptoms including headache, edema and peau d'orange. An important gene associated with Brain Edema is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Pathways in cancer and Selenium Micronutrient Network. The drugs Mannitol and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and lung, and related phenotypes are growth/size/body region and behavior/neurological

Wikipedia : 72 Cerebral edema is excess accumulation of fluid in the intracellular or extracellular spaces of the... more...

Related Diseases for Brain Edema

Diseases related to Brain Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 hydrops, lactic acidosis, and sideroblastic anemia 31.4 ALB AQP4 KNG1 MIP VEGFA
2 pneumococcal meningitis 30.2 GLUL MMP9
3 arteriovenous malformation 30.1 IL6 MMP9 VEGFA
4 ischemia 30.1 HMOX1 KNG1 SOD1 VEGFA
5 intracranial hypertension 30.1 AQP1 AQP4 IL1B
6 meningitis 29.8 ALB IL1B IL6 MMP9
7 cerebral hemorrhage 29.7 IL1B SOD1
8 burns 29.6 ALB IL1B
9 arteriovenous fistula 29.4 HMOX1 IL6
10 hepatic encephalopathy 29.3 ALB GLUL IL6 SLC1A2 SLC25A13
11 astrocytoma 29.1 IL1B IL6 MMP9 VEGFA
12 malaria 28.6 ALB HMOX1 IL1B IL6 MMP9 VEGFA
13 encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy 12.3
14 acute mountain sickness 11.5
15 citrullinemia, type ii, adult-onset 10.9
16 encephalopathy, acute, infection-induced 4 10.9
17 holocarboxylase synthetase deficiency 10.9
18 mitochondrial complex i deficiency due to acad9 deficiency 10.8
19 cerebritis 10.5
20 critical limb ischemia 10.5 IL6 VEGFA
21 brain injury 10.5
22 angiokeratoma circumscriptum 10.4 MMP9 VEGFA
23 traumatic brain injury 10.4
24 acute hemorrhagic leukoencephalitis 10.4 AQP1 AQP4 VEGFA
25 inappropriate adh syndrome 10.3 AQP1 AQP4
26 intermittent claudication 10.3 ALB IL6 VEGFA
27 obstructive jaundice 10.3 ALB IL6 SLC25A13
28 squamous cell carcinoma of the hypopharynx 10.3 MMP9 VEGFA
29 recurrent corneal erosion 10.3 IL1B IL6
30 dysferlinopathy 10.3 AQP1 AQP4 MIP
31 meningitis and encephalitis 10.3 ALB SOD1
32 central pontine myelinolysis 10.3 AQP1 AQP4
33 meniere disease 10.3 AQP1 AQP4 MIP
34 bagassosis 10.3 IL1B IL6
35 meningioma, familial 10.3
36 diabetes insipidus, nephrogenic, autosomal 10.3 AQP1 AQP4 MIP
37 diabetic foot ulcers 10.3 IL6 MMP9
38 peripheral vascular disease 10.3 ALB IL6 VEGFA
39 infantile liver failure syndrome 1 10.3
40 acute transverse myelitis 10.3 AQP4 IL6 MMP9
41 sick building syndrome 10.3 MMP9 VEGFA
42 transverse myelitis 10.3 AQP4 IL6 MMP9
43 chronic follicular conjunctivitis 10.3 IL1B MMP9
44 acute liver failure 10.3
45 periodontitis, chronic 10.3 IL1B IL6
46 rosacea 10.2 IL6 MMP9 VEGFA
47 severe pre-eclampsia 10.2 ALB MMP9 VEGFA
48 enteropathica 10.2 ALB OTC
49 spinal cord injury 10.2 AQP4 IL6 MMP9
50 pleural disease 10.2 ALB IL1B KNG1

Comorbidity relations with Brain Edema via Phenotypic Disease Network (PDN):


Acute Cystitis Brain Cancer
Brain Compression Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Hypertension, Essential

Graphical network of the top 20 diseases related to Brain Edema:



Diseases related to Brain Edema

Symptoms & Phenotypes for Brain Edema

UMLS symptoms related to Brain Edema:


headache, edema, peau d'orange

MGI Mouse Phenotypes related to Brain Edema:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.27 SOD1 OTC IL6 VEGFA SLC1A2 KNG1
2 behavior/neurological MP:0005386 10.26 SOD1 OTC IL6 VEGFA SLC1A2 MMP9
3 homeostasis/metabolism MP:0005376 10.25 OTC IL6 VEGFA SLC1A2 SLC25A13 MMP9
4 cellular MP:0005384 10.19 MMP9 SOD1 OTC IL6 VEGFA SLC1A2
5 mortality/aging MP:0010768 10.17 OTC IL6 VEGFA SLC1A2 SLC25A13 MMP9
6 cardiovascular system MP:0005385 10.16 MMP9 SOD1 IL1B IL6 VEGFA HMOX1
7 endocrine/exocrine gland MP:0005379 10.13 SOD1 OTC IL6 VEGFA HMOX1 AQP4
8 hematopoietic system MP:0005397 10.13 SOD1 IL1B OTC IL6 VEGFA MMP9
9 liver/biliary system MP:0005370 9.97 SOD1 OTC IL6 VEGFA SLC25A13 HMOX1
10 nervous system MP:0003631 9.85 MMP9 SOD1 IL1B OTC IL6 VEGFA
11 neoplasm MP:0002006 9.73 MMP9 SOD1 IL1B IL6 VEGFA ALB
12 renal/urinary system MP:0005367 9.65 OTC IL6 VEGFA SLC25A13 MMP9 AQP4
13 reproductive system MP:0005389 9.23 MMP9 SOD1 OTC IL6 VEGFA AQP1

Drugs & Therapeutics for Brain Edema

Drugs for Brain Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 309)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 6251 453
2
Temozolomide Approved, Investigational Phase 4,Phase 3,Phase 2 85622-93-1 5394
3
Acetazolamide Approved, Vet_approved Phase 4,Phase 2 59-66-5 1986
4
Progesterone Approved, Vet_approved Phase 4,Phase 1,Phase 2 57-83-0 5994
5
Glyburide Approved Phase 4,Phase 3,Phase 1,Phase 2 10238-21-8 3488
6
Conivaptan Approved, Investigational Phase 4,Phase 2,Phase 1 210101-16-9 151171
7
Histamine Approved, Investigational Phase 4,Phase 2 51-45-6, 75614-87-8 774
8
Dacarbazine Approved, Investigational Phase 4 4342-03-4 5351166
9 diuretics Phase 4,Phase 3,Phase 2,Phase 1
10 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1,Early Phase 1
12 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
13 Hormones Phase 4,Phase 3,Phase 2,Phase 1
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
15 Alkylating Agents Phase 4,Phase 3,Phase 2
16 Tissue Plasminogen Activator Phase 4,Phase 2
17 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Early Phase 1
18 Anticonvulsants Phase 4,Phase 3,Phase 2
19 Carbonic Anhydrase Inhibitors Phase 4
20 Progestins Phase 4,Phase 1,Phase 2
21 Hypoglycemic Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Neuromuscular Blocking Agents Phase 4,Phase 2
23 Arginine Vasopressin Phase 4,Phase 3,Phase 2,Phase 1
24 Vasopressins Phase 4,Phase 3,Phase 2,Phase 1
25 calcium channel blockers Phase 4,Phase 2,Phase 3
26 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1
27 Histamine Antagonists Phase 4,Phase 2
28
Histamine Phosphate Phase 4,Phase 2 51-74-1 65513
29
Quinine Approved Phase 2, Phase 3 130-95-0 3034034 8549
30
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
31
Tolvaptan Approved Phase 3 150683-30-0 216237
32
Acetaminophen Approved Phase 3 103-90-2 1983
33
Glycerol Approved, Investigational Phase 3 56-81-5 753
34
Labetalol Approved Phase 2, Phase 3 36894-69-6 3869
35
Loperamide Approved Phase 3 53179-11-6 3955
36
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
37
Angiotensin II Approved, Investigational Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
38
Losartan Approved Phase 3 114798-26-4 3961
39
Artesunate Approved, Investigational Phase 3 88495-63-0 5464098 6917864
40 Piracetam Approved, Investigational Phase 3 7491-74-9
41 Tocopherol Approved, Investigational, Nutraceutical Phase 3
42
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 54670067 5785
43
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
44 Etiracetam Investigational Phase 3 33996-58-6
45 Antimalarials Phase 2, Phase 3
46 Epoetin alfa Phase 2, Phase 3 113427-24-0
47 Hematinics Phase 2, Phase 3
48 Antiemetics Phase 3,Phase 2,Early Phase 1
49 Anti-Inflammatory Agents Phase 3,Phase 2
50 Antineoplastic Agents, Hormonal Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 139)

# Name Status NCT ID Phase Drugs
1 Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy Completed NCT02037815 Phase 4 20% mannitol solution, 125 ml, IV infusion in 15 min;3.1% sodium chloride solution, 125 ml, IV infusion in 15 min
2 Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing Completed NCT01993667 Phase 4 Acetazolamide
3 Does Oral Micronized Progesterone Shorten Time of Symptoms From Concussion Completed NCT01809639 Phase 4 Progesterone;Placebo
4 Supra-early Post-Surgery Chemotherapy in the Treatment on GBM Patients Recruiting NCT02520635 Phase 4 supra-early TEMODAL® chemotherapy;standard TEMODAL® chemotherapy
5 Safety and Efficacy of Glibenclamide Combined With Rt-PA in Acute Cerebral Embolism Not yet recruiting NCT03284463 Phase 4 Glibenclamide;Placebo
6 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
7 Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients Terminated NCT00727090 Phase 4 Conivaptan
8 The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients Withdrawn NCT01526876 Phase 4 clevidipine butyrate
9 Randomized Trial of Erythropoietin During Cerebral Malaria Unknown status NCT00697164 Phase 2, Phase 3 Placebo;Erythropoietin
10 High Dose Hyperoncotic Serum Albumin for the Treatment of the Acute Phase of Severe Head Injury Unknown status NCT00152685 Phase 2, Phase 3 human serum albumin
11 XERECEPT® (hCRF) for Patients Requiring Dexamethasone to Treat Edema Associated With Brain Tumors Completed NCT00088166 Phase 3 hCRF;placebo hCRF
12 An Open-Labeled, Extended-Use of XERECEPT (hCRF) for Patients in Studies NTI 0302, 0303, or Other Designated Studies Completed NCT00226655 Phase 3 hCRF [XERECEPT (corticorelin acetate injection)]
13 Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis Completed NCT01365793 Phase 3 0.45% saline replacement fluid;0.9% saline replacement fluid;0.45% saline intravenous fluid;0.9% saline Intravenous fluid
14 Effect of Tolvaptan on Cognitive Function in Cirrhosis Completed NCT01556646 Phase 3 Tolvaptan
15 Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness Completed NCT00664001 Phase 3
16 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Completed NCT00619203 Phase 3 Glycerol and paracetamol;Paracetamol;Paracetamol;Paracetamol;Placebo;Paracetamol and glycerol;Glycerol
17 Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury Recruiting NCT03339505 Phase 3
18 Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma Active, not recruiting NCT01805453 Phase 3 Losartan;Placebo
19 Treating Brain Swelling in Pediatric Cerebral Malaria Not yet recruiting NCT03300648 Phase 3
20 CIRARA in Large Hemispheric Infarction Analyzing Modified Rankin Scale (mRS) and Mortality (CHARM) Not yet recruiting NCT02864953 Phase 3 CIRARA (glyburide for injection);Placebo (for CIRARA)
21 Prevention of Epileptic Seizures in Acute intraCerebral Haemorrhage Not yet recruiting NCT02631759 Phase 3 Lévétiracetam;Placebo
22 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
23 Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts Terminated NCT00190203 Phase 3
24 Induced Hypertension for Treatment of Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage Terminated NCT01613235 Phase 3
25 XERECEPT® (hCRF) for Primary Glioma Patients Requiring Dexamethasone to Treat Peritumoral Brain Edema Withdrawn NCT00226668 Phase 3 hCRF;placebo hCRF
26 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
27 Feasibility Study of New MRI Protocol in Assessing Early Blood Brain Barrier Disruption (BBBD)in Related to Delay Brain Edema Unknown status NCT01830894 Phase 1, Phase 2
28 a Phase II Study in Primary Central Nervous System Lymphoma Unknown status NCT00455286 Phase 2 Methotrexate;Methylprednisolone;Temozolomide
29 NSAID RCT for Prevention of Altitude Sickness Unknown status NCT01606527 Phase 2 Ibuprofen 600mg orally three times daily
30 Targeted Temperature Management After Intracerebral Hemorrhage Unknown status NCT01866384 Phase 2
31 A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. EMCOOLS Flex.Pads (iCOOL 2) Unknown status NCT01584167 Phase 2 Cold crystalloid infusions, 0.9%NaCl or Ringer's solution
32 Safety and Feasibility Study of Targeted Temperature Management After ICH Unknown status NCT01607151 Phase 1, Phase 2
33 Continuous Endostar Infusion Combined With Radiotherapy in Patients With Brain Metastases Unknown status NCT01410370 Phase 2 Endostar
34 A Study of the Safety, Imaging and Clinical Outcomes of THR-18 in Acute Stroke Subjects Treated With tPA Unknown status NCT02572336 Phase 2 THR-18;Placebo;Tissue Plasminogen Activator (tPA)
35 Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure Unknown status NCT00470314 Phase 2 L-Ornithine L-Aspartate
36 Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke Completed NCT01428401 Phase 2 Chinese Herb Astragalus membranaceus
37 Histamine Glutamate Antagonism in Stroke Completed NCT02142712 Phase 2 Diphenhydramine;Pantoprazole;Famotidine;Dextromethorphan
38 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion Completed NCT00777140 Phase 2 Deferoxamine
39 Glyburide Advantage in Malignant Edema and Stroke Pilot Completed NCT01268683 Phase 1, Phase 2 RP-1127 (Glyburide for injection)
40 A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients Completed NCT01282242 Phase 2 IV rt-PA
41 Study of Rifaximin in Minimal Hepatic Encephalopathy Completed NCT01069133 Phase 1, Phase 2 Rifaximin;rifaximin
42 Progesterone Treatment of Blunt Traumatic Brain Injury Completed NCT00048646 Phase 1, Phase 2 IV Progesterone
43 Fluid Therapy During Brain Tumor Resection in Children Completed NCT02707549 Phase 2 balanced crystalloid solution (components: sodium chloride, sodium gluconate, sodium acetate, potassium chloride and magnesium chloride);0.9% sodium chloride
44 A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. RhinoChill (iCOOL 1) Completed NCT01573117 Phase 2 Cold crystalloid infusions, 0.9%NaCl or Ringer's solution
45 A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. EMCOOLS Brain.Pad (iCOOL 3) Completed NCT01584180 Phase 2 Cold crystalloid infusions, 0.9%NaCl or Ringer's
46 Safety of Pioglitazone for Hematoma Resolution In Intracerebral Hemorrhage Completed NCT00827892 Phase 2 Pioglitazone;Placebo Control
47 Dexmedetomidine vs. Remifentanil for Pre-eclampsia During Caesarean Delivery Completed NCT01766089 Phase 2 Remifentanil;Dexmedetomidine
48 Hypothermia for Cardiac Arrest in Paediatrics Completed NCT00754481 Phase 2
49 Sirolimus in Treating Patients With Glioblastoma Multiforme Completed NCT00047073 Phase 1, Phase 2 Rapamycin
50 Pilot Study For Hypothermia Treatment In Hyperammonemic Encephalopathy In Neonates And Very Young Infants Completed NCT01624311 Phase 2

Search NIH Clinical Center for Brain Edema

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: brain edema

Genetic Tests for Brain Edema

Genetic tests related to Brain Edema:

# Genetic test Affiliating Genes
1 Cerebral Edema 28

Anatomical Context for Brain Edema

MalaCards organs/tissues related to Brain Edema:

38
Brain, Liver, Lung, Endothelial, Bone, Heart, Testes

Publications for Brain Edema

Articles related to Brain Edema:

(show top 50) (show all 666)
# Title Authors Year
1
Case Report: A Case of Severe Cerebral Malaria Managed with Therapeutic Hypothermia and Other Modalities for Brain Edema. ( 29405103 )
2018
2
Goreisan Prevents Brain Edema after Cerebral Ischemic Stroke by Inhibiting Aquaporin 4 Upregulation in Mice. ( 29153303 )
2018
3
Low-dose bevacizumab as an effective pre-treatment for peri-tumoral brain edema prior to CyberKnife radiosurgery: A case report. ( 29420112 )
2018
4
Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema. ( 29434965 )
2018
5
Association of Reperfusion With Brain Edema in Patients With Acute Ischemic Stroke: A Secondary Analysis of the MR CLEAN Trial. ( 29365017 )
2018
6
Erythropoietin Attenuates the Brain Edema Response after Experimental Traumatic Brain Injury. ( 29179621 )
2018
7
Disruption of Intracellular ATP Generation and Tight Junction Protein Expression during the Course of Brain Edema Induced by Subacute Poisoning of 1,2-Dichloroethane. ( 29410610 )
2018
8
Angiopoietin-Like 4 Attenuates Brain Edema and Neurological Deficits in a Mouse Model of Experimental Intracerebral Hemorrhage. ( 29432410 )
2018
9
Early Non-anticoagulant Desulfated Heparin After TBI: Reduced Brain Edema and Leukocyte Mobilization is Associated with Improved Watermaze Learning Ability Weeks After Injury. ( 29373460 )
2018
10
Unenhanced Dual-Energy Computed Tomography: Visualization of Brain Edema. ( 28915161 )
2017
11
Report - Cerebral electrical impedance value reflects brain edema caused by cardiopulmonary bypass in infants. ( 28653939 )
2017
12
Raised intracranial pressure and brain edema. ( 28987174 )
2017
13
Prediction of Histological Grade and Completeness of Resection of Intracranial Meningiomas: Role of Peritumoural Brain Edema. ( 28814931 )
2017
14
Reduction of Ischemic Brain Edema by Combined use of Paeoniflorin and Astragaloside IV via Down-Regulating Connexin 43. ( 28752625 )
2017
15
Chiari Type 1 Malformation-induced Intracranial Hypertension with Diffuse Brain Edema Treated with Foramen Magnum Decompression: A Case Report. ( 29018653 )
2017
16
TiO2-Nanowired Delivery of DL-3-n-butylphthalide (DL-NBP) Attenuates Blood-Brain Barrier Disruption, Brain Edema Formation, and Neuronal Damages Following Concussive Head Injury. ( 28856586 )
2017
17
An experimental model of the "dual diagnosis": Effect of cytotoxic brain edema plus peripheral neuropathy on the spontaneous locomotor activity of rats. ( 29298281 )
2017
18
Sustained (S)-roscovitine delivery promotes neuroprotection associated with functional recovery and decrease in brain edema in a randomized blind focal cerebral ischemia study. ( 28569655 )
2017
19
Delayed Brain Edema and Swelling following Craniectomy for Evacuation of an Epidural Abscess that Improved by Cranioplasty: Case Report. ( 28852606 )
2017
20
Mathematical model in post-mortem estimation of brain edema using morphometric parameters. ( 27914998 )
2017
21
Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability and endothelial glycocalyx disruption following fluid-percussion brain injury in the rat. ( 28930945 )
2017
22
Epilepsia partialis continua induces transient brain edema. ( 28658412 )
2017
23
Corrigendum to "The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema-in vivo kinetic study of 5-aminolevulinic acid and talaporfin sodium" [Photodiagn. Photodyn. Ther. 6 (2009), 19-27]. ( 28619661 )
2017
24
Neuroprotective Effects of Exercise on Brain Edema and Neurological Movement Disorders Following the Cerebral Ischemia and Reperfusion in Rats. ( 28446953 )
2017
25
Simulating vasogenic brain edema using chronic VEGF infusion. ( 28059647 )
2017
26
Apatinib in refractory radiation-induced brain edema: A case report. ( 29145238 )
2017
27
Efficacy and safety of bevacizumab treatment for refractory brain edema: Case report. ( 29095257 )
2017
28
Brain edema with clasmatodendrosis complicating ataxia telangiectasia. ( 28351596 )
2017
29
Noninvasive monitoring of brain edema after hypoxia in newborn piglets. ( 29069074 )
2017
30
Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated with brain edema following fatal heat stroke. ( 28490769 )
2017
31
Reperfusion after ischemic stroke is associated with reduced brain edema. ( 28731381 )
2017
32
Therapeutic time window for conivaptan treatment against stroke-evoked brain edema and blood-brain barrier disruption in mice. ( 28854286 )
2017
33
Magnesium Sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. ( 29288747 )
2017
34
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model. ( 29039533 )
2017
35
Permeability surface area product analysis in malignant brain edema prediction - A pilot study. ( 28431614 )
2017
36
Glycocalyx degradation leads to blood-brain barrier dysfunction and brain edema after asphyxia cardiac arrest in rats. ( 28825336 )
2017
37
Three-dimensional organ scanning reveals brain edema reduction in a rat model of stroke treated with an aquaporin 4 inhibitor. ( 28523299 )
2017
38
Evaluation of Brain Edema Formation Defined By MRI After LINAC-based Stereotactic Radiosurgery. ( 28740448 )
2017
39
The Subarachnoid Hemorrhage Early Brain Edema Score Predicts Delayed Cerebral Ischemia and Clinical Outcomes. ( 28973675 )
2017
40
Quantitative MRI study of the permeability of peritumoral brain edema in lung cancer patients with brain metastases. ( 28633995 )
2017
41
Asymptomatic Brain Edema after Hemodialysis Initiation in a Patient with Severe Uremia. ( 28553356 )
2017
42
Effects of Gender and Estrogen Receptors on Iron-Induced Brain Edema Formation. ( 26463972 )
2016
43
Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture. ( 27914011 )
2016
44
Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases. ( 26942067 )
2016
45
Clinical Outcomes of Wulingsan Subtraction Decoction Treatment of Postoperative Brain Edema and Fever as a Complication of Glioma Neurosurgery. ( 27019661 )
2016
46
YiQiFuMai powder injection ameliorates blood-brain barrier dysfunction and brain edema after focal cerebral ischemia-reperfusion injury in mice. ( 26834461 )
2016
47
Human neuronal changes in brain edema and increased intracranial pressure. ( 27487831 )
2016
48
Valproic Acid Pretreatment Reduces Brain Edema in a Rat Model of Surgical Brain Injury. ( 26463966 )
2016
49
Overexpression of caveolin-1 attenuates brain edema by inhibiting tight junction degradation. ( 27708218 )
2016
50
TRPV4 channels mediate Na-K-Cl-co-transporter-induced brain edema after traumatic brain injury. ( 27926982 )
2016

Variations for Brain Edema

Expression for Brain Edema

Search GEO for disease gene expression data for Brain Edema.

Pathways for Brain Edema

Pathways related to Brain Edema according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1 12.64 BDKRB2 HMOX1 IL6 MMP9 VEGFA
2
Show member pathways
12.13 ALB IL1B IL6 SOD1
3 11.97 AQP4 IL1B IL6 VEGFA
4 11.88 HMOX1 IL1B MMP9 VEGFA
5 11.79 IL1B IL6 MMP9
6 11.74 HMOX1 IL6 VEGFA
7 11.73 IL1B IL6 VEGFA
8 11.68 IL1B IL6 VEGFA
9 11.43 AQP1 AQP4 IL1B IL6 MMP9
10 11.36 HMOX1 IL1B IL6 MMP9
11 11.33 IL6 KNG1 MMP9
12
Show member pathways
11.26 IL1B IL6 MMP9 VEGFA
13 11.12 HMOX1 IL1B IL6
14 11.09 IL1B IL6 SOD1
15 11.08 HMOX1 IL1B IL6 MMP9 VEGFA
16 11.03 HMOX1 IL6 MMP9
17 10.62 IL1B IL6
18
Show member pathways
10.41 GLUL SLC1A2

GO Terms for Brain Edema

Cellular components related to Brain Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 9.33 IL1B SOD1 VEGFA
2 extracellular space GO:0005615 9.28 ALB HMOX1 IL1B IL6 KNG1 MMP9
3 platelet alpha granule lumen GO:0031093 9.13 ALB KNG1 VEGFA

Biological processes related to Brain Edema according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.96 AQP1 AQP4 MIP SLC1A2 SLC25A13
2 response to drug GO:0042493 9.84 AQP1 OTC SLC1A2 SOD1
3 positive regulation of apoptotic process GO:0043065 9.8 HMOX1 IL6 KNG1 MMP9 SOD1
4 cellular response to hypoxia GO:0071456 9.7 AQP1 HMOX1 VEGFA
5 positive regulation of angiogenesis GO:0045766 9.62 AQP1 HMOX1 IL1B VEGFA
6 platelet degranulation GO:0002576 9.56 ALB KNG1 SOD1 VEGFA
7 macrophage differentiation GO:0030225 9.55 MMP9 VEGFA
8 embryo implantation GO:0007566 9.54 IL1B MMP9 SOD1
9 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.51 IL1B VEGFA
10 L-glutamate transmembrane transport GO:0089711 9.49 SLC1A2 SLC25A13
11 L-glutamate transport GO:0015813 9.48 SLC1A2 SLC25A13
12 positive regulation of chemokine biosynthetic process GO:0045080 9.46 HMOX1 IL1B
13 multicellular organismal water homeostasis GO:0050891 9.43 AQP1 AQP4
14 negative regulation of apoptotic process GO:0043066 9.43 ALB AQP1 IL6 MMP9 SOD1 VEGFA
15 cellular response to cadmium ion GO:0071276 9.33 HMOX1 MMP9 SOD1
16 water transport GO:0006833 8.8 AQP1 AQP4 MIP

Molecular functions related to Brain Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 ALB AQP1 GLUL MMP9 SOD1 VEGFA
2 L-glutamate transmembrane transporter activity GO:0005313 9.26 SLC1A2 SLC25A13
3 water transmembrane transporter activity GO:0005372 9.16 AQP1 AQP4
4 channel activity GO:0015267 9.13 AQP1 AQP4 MIP
5 water channel activity GO:0015250 8.8 AQP1 AQP4 MIP

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