Aliases & Classifications for Brain Edema

MalaCards integrated aliases for Brain Edema:

Name: Brain Edema 12 52 42 14 69
Intracranial Swelling 12
Cerebral Edema 69
Wet Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4724
MeSH 42 D001929
SNOMED-CT 64 2032001 85974009
UMLS 69 C1527311

Summaries for Brain Edema

MalaCards based summary : Brain Edema, also known as intracranial swelling, is related to choroiditis and malaria, and has symptoms including edema, joint swelling and headache. An important gene associated with Brain Edema is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Fluid shear stress and atherosclerosis. The drugs Mannitol and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and endothelial, and related phenotypes are homeostasis/metabolism and behavior/neurological

Related Diseases for Brain Edema

Diseases related to Brain Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
id Related Disease Score Top Affiliating Genes
1 choroiditis 29.6 ALB IL1B IL6
2 malaria 28.2 ALB HMOX1 IL1B IL6 MMP9 VEGFA
3 encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy 12.2
4 encephalopathy, acute, infection-induced, 4 10.8
5 citrullinemia, adult-onset type ii 10.8
6 cutaneous leishmaniasis 10.7 IL6 VEGFA
7 mitochondrial complex i deficiency due to acad9 deficiency 10.6
8 crohn disease-associated growth failure 10.6 IL6 VEGFA
9 kidney pelvis papillary carcinoma 10.6 MMP9 VEGFA
10 ischemic heart disease 10.5 ALB IL6 VEGFA
11 paranasal sinus sarcoma 10.5 ALB IL6 SLC25A13
12 myoclonic encephalopathy of infants 10.5 ALB SOD1
13 lens disease 10.5 AQP1 AQP4 VEGFA
14 oculomotor nerve paralysis 10.5 IL1B IL6
15 hypersplenism 10.5 AQP1 AQP4
16 drug rash with eosinophilia and systemic symptoms 10.5 AQP4 IL6 MMP9
17 common peroneal nerve lesion 10.5 IL1B IL6
18 tricho onychic dysplasia 10.5 AQP4 IL6 MMP9
19 efemp2-related cutis laxa 10.4 AQP1 AQP4 MIP
20 angina pectoris 10.4 ALB IL6 VEGFA
21 exophthalmic ophthalmoplegia 10.4 ALB MMP9 VEGFA
22 cerebritis 10.4
23 pityriasis rosea 10.4 IL6 MMP9 VEGFA
24 toxic optic neuropathy 10.4 IL1B MMP9
25 hepatic vascular disease 10.4 MMP9 VEGFA
26 pituitary infarct 10.4 IL6 MMP9 VEGFA
27 interstitial keratitis 10.4 AQP1 AQP4 MIP
28 spinal stenosis 10.4 AQP4 IL6 MMP9
29 male reproductive organ cancer 10.4 MMP9 VEGFA
30 pleural tuberculosis 10.4 ALB IL6 VEGFA
31 palmoplantar keratoderma, bothnian type 10.4 AQP1 AQP4 MIP
32 brain injury 10.4
33 arthus reaction 10.4 ALB IL1B KNG1
34 testicular granulosa cell tumor 10.4 GLUL IL6 VEGFA
35 bipolar i disorder 10.4 IL1B IL6 VEGFA
36 neonatal jaundice 10.4 AQP4 IL6 MMP9
37 retinitis pigmentosa 70 10.4 ALB VEGFA
38 acquired thrombocytopenia 10.3 IL1B IL6 KNG1
39 congenital nonspherocytic hemolytic anemia 10.3 ALB IL1B IL6
40 retinitis pigmentosa 10.3 KNG1 SOD1 VEGFA
41 mikulicz disease 10.3 ALB IL1B IL6
42 spondylolysis 10.3 IL1B IL6 VEGFA
43 rift valley fever 10.3 ALB IL1B IL6
44 carcinoma arising in nasal papillomatosis 10.3 ALB IL1B IL6
45 traumatic brain injury 10.3
46 diamond-blackfan anemia 1 10.3 ALB IL6 MMP9
47 colon adenocarcinoma 10.3 ALB IL1B IL6
48 opportunistic bacterial infectious disease 10.3 ALB IL1B IL6
49 ischemia 10.3
50 endometrial clear cell adenocarcinoma 10.3 ALB IL1B IL6

Comorbidity relations with Brain Edema via Phenotypic Disease Network (PDN):


Acute Cystitis Brain Cancer
Brain Compression Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Hypertension, Essential

Graphical network of the top 20 diseases related to Brain Edema:



Diseases related to Brain Edema

Symptoms & Phenotypes for Brain Edema

UMLS symptoms related to Brain Edema:


edema, joint swelling, headache

MGI Mouse Phenotypes related to Brain Edema:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 VEGFA ALB ANXA1 AQP1 AQP4 BDKRB2
2 behavior/neurological MP:0005386 10.24 AQP1 AQP4 BDKRB2 GLUL HMOX1 IL6
3 growth/size/body region MP:0005378 10.23 HMOX1 IL6 KNG1 MMP9 SLC1A2 SLC25A13
4 cardiovascular system MP:0005385 10.22 ANXA1 AQP1 AQP4 BDKRB2 HMOX1 IL1B
5 cellular MP:0005384 10.21 GLUL HMOX1 IL6 MMP9 SLC1A2 SOD1
6 mortality/aging MP:0010768 10.17 ALB ANXA1 AQP1 AQP4 BDKRB2 GLUL
7 endocrine/exocrine gland MP:0005379 10.13 ALB ANXA1 AQP1 AQP4 BDKRB2 HMOX1
8 hematopoietic system MP:0005397 10.13 ANXA1 AQP1 AQP4 BDKRB2 HMOX1 IL1B
9 digestive/alimentary MP:0005381 10.04 AQP4 BDKRB2 IL6 MMP9 VEGFA ALB
10 liver/biliary system MP:0005370 9.91 ALB GLUL HMOX1 IL6 SLC25A13 SOD1
11 nervous system MP:0003631 9.85 ANXA1 AQP1 AQP4 GLUL IL1B IL6
12 neoplasm MP:0002006 9.8 VEGFA ALB ANXA1 IL1B IL6 MMP9
13 renal/urinary system MP:0005367 9.61 ALB AQP1 AQP4 BDKRB2 HMOX1 IL6
14 skeleton MP:0005390 9.23 ANXA1 AQP1 BDKRB2 IL1B IL6 MMP9

Drugs & Therapeutics for Brain Edema

Drugs for Brain Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 318)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 453 6251
2
Temozolomide Approved, Investigational Phase 4,Phase 3,Phase 2 85622-93-1 5394
3
Glyburide Approved Phase 4,Phase 3,Phase 2,Phase 1 10238-21-8 3488
4
Acetazolamide Approved, Vet_approved Phase 4,Phase 2 59-66-5 1986
5
Progesterone Approved, Vet_approved Phase 4,Phase 1,Phase 2 57-83-0 5994
6
Conivaptan Approved, Investigational Phase 4,Phase 2,Phase 1 210101-16-9 151171
7
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
8
Zinc Approved Phase 4,Phase 1 7440-66-6 32051 23994
9
Benzocaine Approved Phase 4,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
10 tannic acid Approved, Nutraceutical Phase 4,Phase 1,Phase 2
11 diuretics Phase 4,Phase 3,Phase 2,Phase 1
12 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
14 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
15 Hormones Phase 4,Phase 3,Phase 2,Phase 1
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
17 Alkylating Agents Phase 4,Phase 3,Phase 2
18 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Tissue Plasminogen Activator Phase 4,Phase 2
20 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Early Phase 1
21 Anticonvulsants Phase 4,Phase 3,Phase 2
22 Carbonic Anhydrase Inhibitors Phase 4
23 Progestins Phase 4,Phase 1,Phase 2
24 Neuromuscular Blocking Agents Phase 4,Phase 2
25 Arginine Vasopressin Phase 4,Phase 3,Phase 2,Phase 1
26 Vasopressins Phase 4,Phase 3,Phase 2,Phase 1
27 calcium channel blockers Phase 4,Phase 2,Phase 3
28 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1
29 Histamine Antagonists Phase 4,Phase 2
30
Histamine Phosphate Phase 4,Phase 2 51-74-1 65513
31 Vasodilator Agents Phase 4,Phase 1,Phase 2
32 Natriuretic Peptide, Brain Phase 4
33 insulin Phase 4
34 Insulin, Globin Zinc Phase 4
35
Quinine Approved Phase 2, Phase 3 130-95-0 8549 3034034
36
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 50-02-2 5743
37
Tolvaptan Approved Phase 3 150683-30-0 216237
38
Acetaminophen Approved Phase 3 103-90-2 1983
39
Glycerol Approved, Investigational Phase 3 56-81-5 753
40
Dobutamine Approved Phase 3 34368-04-2 36811
41
Furosemide Approved, Vet_approved Phase 3 54-31-9 3440
42
Isosorbide Dinitrate Approved Phase 3 87-33-2 6883
43
Labetalol Approved Phase 2, Phase 3 36894-69-6 3869
44
Magnesium Sulfate Approved, Vet_approved Phase 2, Phase 3 7487-88-9 24083
45
Losartan Approved Phase 3 114798-26-4 3961
46 Piracetam Approved Phase 3 7491-74-9
47 Tocopherol Approved, Nutraceutical Phase 3
48
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
49
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
50 Etiracetam Investigational Phase 3 33996-58-6

Interventional clinical trials:

(show top 50) (show all 159)

id Name Status NCT ID Phase Drugs
1 Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy Completed NCT02037815 Phase 4 20% mannitol solution, 125 ml, IV infusion in 15 min;3.1% sodium chloride solution, 125 ml, IV infusion in 15 min
2 Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing Completed NCT01993667 Phase 4 Acetazolamide
3 Does Oral Micronized Progesterone Shorten Time of Symptoms From Concussion Completed NCT01809639 Phase 4 Progesterone;Placebo
4 Supra-early Post-Surgery Chemotherapy in the Treatment on GBM Patients Recruiting NCT02520635 Phase 4 supra-early TEMODAL® chemotherapy;standard TEMODAL® chemotherapy
5 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS) Recruiting NCT02529475 Phase 4 Gadoteric acid
6 NT-proBNP and New Biomarkers in Patients With Dyspnea and/or Peripheral Edema Active, not recruiting NCT00143793 Phase 4
7 Safety and Efficacy of Glibenclamide Combined With Rt-PA in Acute Cerebral Embolism Not yet recruiting NCT03284463 Phase 4 Glibenclamide;Placebo
8 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
9 Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients Terminated NCT00727090 Phase 4 Conivaptan
10 Normoglycemia and Neurological Outcome Terminated NCT01137773 Phase 4 Insulin;Conventional insulin treatment
11 The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients Withdrawn NCT01526876 Phase 4 clevidipine butyrate
12 Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal EF Withdrawn NCT00505791 Phase 4 Nesiritide
13 Randomized Trial of Erythropoietin During Cerebral Malaria Unknown status NCT00697164 Phase 2, Phase 3 Placebo;Erythropoietin
14 High Dose Hyperoncotic Serum Albumin for the Treatment of the Acute Phase of Severe Head Injury Unknown status NCT00152685 Phase 2, Phase 3 human serum albumin
15 XERECEPT® (hCRF) for Patients Requiring Dexamethasone to Treat Edema Associated With Brain Tumors Completed NCT00088166 Phase 3 hCRF;placebo hCRF
16 An Open-Labeled, Extended-Use of XERECEPT (hCRF) for Patients in Studies NTI 0302, 0303, or Other Designated Studies Completed NCT00226655 Phase 3 hCRF [XERECEPT (corticorelin acetate injection)]
17 Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis Completed NCT01365793 Phase 3 0.45% saline replacement fluid;0.9% saline replacement fluid;0.45% saline intravenous fluid;0.9% saline Intravenous fluid
18 Effect of Tolvaptan on Cognitive Function in Cirrhosis Completed NCT01556646 Phase 3 Tolvaptan
19 Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness Completed NCT00664001 Phase 3
20 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Completed NCT00619203 Phase 3 Glycerol and paracetamol;Paracetamol;Paracetamol;Paracetamol;Placebo;Paracetamol and glycerol;Glycerol
21 Continuous Positive Airway Pressure for Acute Pulmonary Edema Completed NCT00554580 Phase 3
22 Non-Invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema: a Multicentre Study Completed NCT00785174 Phase 3
23 Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma Active, not recruiting NCT01805453 Phase 3 Losartan;Placebo
24 Neuromonitoring in Patients During Aortic Valve Replacement Enrolling by invitation NCT02697786 Phase 3
25 Treating Brain Swelling in Pediatric Cerebral Malaria Not yet recruiting NCT03300648 Phase 3
26 CIRARA in Large Hemispheric Infarction Analyzing Modified Rankin Scale (mRS) and Mortality (CHARM) Not yet recruiting NCT02864953 Phase 3 CIRARA (glyburide for injection);Placebo (for CIRARA)
27 Prevention of Epileptic Seizures in Acute intraCerebral Haemorrhage Not yet recruiting NCT02631759 Phase 3 Lévétiracetam;Placebo
28 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
29 Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts Terminated NCT00190203 Phase 3
30 Induced Hypertension for Treatment of Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage Terminated NCT01613235 Phase 3
31 XERECEPT® (hCRF) for Primary Glioma Patients Requiring Dexamethasone to Treat Peritumoral Brain Edema Withdrawn NCT00226668 Phase 3 hCRF;placebo hCRF
32 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
33 Feasibility Study of New MRI Protocol in Assessing Early Blood Brain Barrier Disruption (BBBD)in Related to Delay Brain Edema Unknown status NCT01830894 Phase 1, Phase 2
34 a Phase II Study in Primary Central Nervous System Lymphoma Unknown status NCT00455286 Phase 2 Methotrexate;Methylprednisolone;Temozolomide
35 Targeted Temperature Management After Intracerebral Hemorrhage Unknown status NCT01866384 Phase 2
36 NSAID RCT for Prevention of Altitude Sickness Unknown status NCT01606527 Phase 2 Ibuprofen 600mg orally three times daily
37 A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. EMCOOLS Flex.Pads (iCOOL 2) Unknown status NCT01584167 Phase 2 Cold crystalloid infusions, 0.9%NaCl or Ringer's solution
38 Safety and Feasibility Study of Targeted Temperature Management After ICH Unknown status NCT01607151 Phase 1, Phase 2
39 Continuous Endostar Infusion Combined With Radiotherapy in Patients With Brain Metastases Unknown status NCT01410370 Phase 2 Endostar
40 A Study of the Safety, Imaging and Clinical Outcomes of THR-18 in Acute Stroke Subjects Treated With tPA Unknown status NCT02572336 Phase 2 THR-18;Placebo;Tissue Plasminogen Activator (tPA)
41 Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure Unknown status NCT00470314 Phase 2 L-Ornithine L-Aspartate
42 Glyburide (RP-1127) for Traumatic Brain Injury (TBI) Unknown status NCT01454154 Phase 2 Glyburide;Placebo
43 Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke Completed NCT01428401 Phase 2 Chinese Herb Astragalus membranaceus
44 Histamine Glutamate Antagonism in Stroke Completed NCT02142712 Phase 2 Diphenhydramine;Pantoprazole;Famotidine;Dextromethorphan
45 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion Completed NCT00777140 Phase 2 Deferoxamine
46 Glyburide Advantage in Malignant Edema and Stroke Pilot Completed NCT01268683 Phase 1, Phase 2 RP-1127 (Glyburide for injection)
47 Study of Rifaximin in Minimal Hepatic Encephalopathy Completed NCT01069133 Phase 1, Phase 2 Rifaximin;rifaximin
48 A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients Completed NCT01282242 Phase 2 IV rt-PA
49 Progesterone Treatment of Blunt Traumatic Brain Injury Completed NCT00048646 Phase 1, Phase 2 IV Progesterone
50 Safety of Pioglitazone for Hematoma Resolution In Intracerebral Hemorrhage Completed NCT00827892 Phase 2 Pioglitazone;Placebo Control

Search NIH Clinical Center for Brain Edema

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: brain edema

Genetic Tests for Brain Edema

Anatomical Context for Brain Edema

MalaCards organs/tissues related to Brain Edema:

39
Brain, Liver, Endothelial, Lung, Bone, Heart, Testes

Publications for Brain Edema

Articles related to Brain Edema:

(show top 50) (show all 648)
id Title Authors Year
1
Mathematical model in post-mortem estimation of brain edema using morphometric parameters. ( 27914998 )
2017
2
Sustained (S)-roscovitine delivery promotes neuroprotection associated with functional recovery and decrease in brain edema in a randomized blind focal cerebral ischemia study. ( 28569655 )
2017
3
Simulating vasogenic brain edema using chronic VEGF infusion. ( 28059647 )
2017
4
Unenhanced Dual-Energy Computed Tomography: Visualization of Brain Edema. ( 28915161 )
2017
5
Epilepsia partialis continua induces transient brain edema. ( 28658412 )
2017
6
Asymptomatic Brain Edema after Hemodialysis Initiation in a Patient with Severe Uremia. ( 28553356 )
2017
7
Brain edema with clasmatodendrosis complicating ataxia telangiectasia. ( 28351596 )
2017
8
Therapeutic time window for conivaptan treatment against stroke-evoked brain edema and blood-brain barrier disruption in mice. ( 28854286 )
2017
9
Report - Cerebral electrical impedance value reflects brain edema caused by cardiopulmonary bypass in infants. ( 28653939 )
2017
10
Reperfusion after ischemic stroke is associated with reduced brain edema. ( 28731381 )
2017
11
Delayed Brain Edema and Swelling following Craniectomy for Evacuation of an Epidural Abscess that Improved by Cranioplasty: Case Report. ( 28852606 )
2017
12
Glycocalyx degradation leads to blood-brain barrier dysfunction and brain edema after asphyxia cardiac arrest in rats. ( 28825336 )
2017
13
Neuroprotective Effects of Exercise on Brain Edema and Neurological Movement Disorders Following the Cerebral Ischemia and Reperfusion in Rats. ( 28446953 )
2017
14
Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated with brain edema following fatal heat stroke. ( 28490769 )
2017
15
Quantitative MRI study of the permeability of peritumoral brain edema in lung cancer patients with brain metastases. ( 28633995 )
2017
16
Three-dimensional organ scanning reveals brain edema reduction in a rat model of stroke treated with an aquaporin 4 inhibitor. ( 28523299 )
2017
17
Corrigendum to "The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema-in vivo kinetic study of 5-aminolevulinic acid and talaporfin sodium" [Photodiagn. Photodyn. Ther. 6 (2009), 19-27]. ( 28619661 )
2017
18
TiO2-Nanowired Delivery of DL-3-n-butylphthalide (DL-NBP) Attenuates Blood-Brain Barrier Disruption, Brain Edema Formation, and Neuronal Damages Following Concussive Head Injury. ( 28856586 )
2017
19
Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability and endothelial glycocalyx disruption following fluid-percussion brain injury in the rat. ( 28930945 )
2017
20
Reduction of Ischemic Brain Edema by Combined use of Paeoniflorin and Astragaloside IV via Down-Regulating Connexin 43. ( 28752625 )
2017
21
Prediction of Histological Grade and Completeness of Resection of Intracranial Meningiomas: Role of Peritumoural Brain Edema. ( 28814931 )
2017
22
Evaluation of Brain Edema Formation Defined By MRI After LINAC-based Stereotactic Radiosurgery. ( 28740448 )
2017
23
Permeability surface area product analysis in malignant brain edema prediction - A pilot study. ( 28431614 )
2017
24
Effects of metformin treatment on glioma-induced brain edema. ( 27648126 )
2016
25
Vasopressin Hypersecretion-Associated Brain Edema Formation in Ischemic Stroke: Underlying Mechanisms. ( 27068863 )
2016
26
Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema. ( 27684044 )
2016
27
Tongxinluo reduces brain edema and inhibits post-ischemic inflammation after middle cerebral artery occlusion in rats. ( 26805468 )
2016
28
Significance of Primary Tumor Location and Histology for Brain Metastasis Development and Peritumoral Brain Edema in Lung Cancer. ( 27562339 )
2016
29
Unfractionated heparin after TBI reduces in vivo cerebrovascular inflammation, brain edema and accelerates cognitive recovery. ( 27533909 )
2016
30
Valproic Acid Pretreatment Reduces Brain Edema in a Rat Model of Surgical Brain Injury. ( 26463966 )
2016
31
TRPV4 channels mediate Na-K-Cl-co-transporter-induced brain edema after traumatic brain injury. ( 27926982 )
2016
32
Brain Edema after Repeat Gamma Knife Radiosurgery for a Large Arteriovenous Malformation: A Case Report. ( 27574486 )
2016
33
Vascular Endothelial Growth Factor in Brain Edema Formation After Subarachnoid Hemorrhage. ( 26463944 )
2016
34
I^-Dystroglycan cleavage by matrix metalloproteinase-2/-9 disturbs aquaporin-4 polarization and influences brain edema in acute cerebral ischemia. ( 27038751 )
2016
35
Failed First Craniotomy and Tumor Removal of Parasagittal Meningioma with Severe Peritumoral Brain Edema. ( 27867923 )
2016
36
A fatal adverse effect of cefazolin administration: severe brain edema in a patient with multiple meningiomas. ( 26929668 )
2016
37
Curcumin alleviates brain edema by lowering AQP4 expression levels in a rat model of hypoxia-hypercapnia-induced brain damage. ( 26997983 )
2016
38
Fluid Intake Related to Brain Edema in Acute Middle Cerebral Artery Infarction. ( 26666449 )
2016
39
The Role of Matricellular Proteins in Brain Edema after Subarachnoid Hemorrhage. ( 26463940 )
2016
40
YiQiFuMai powder injection ameliorates blood-brain barrier dysfunction and brain edema after focal cerebral ischemia-reperfusion injury in mice. ( 26834461 )
2016
41
The role of extracellular-5'-nucleotidase/CD73 in glioma peritumoural brain edema. ( 26884147 )
2016
42
Automated assessment of early hypoxic brain edema in non-enhanced CT predicts outcome in patients after cardiac arrest. ( 27036663 )
2016
43
Human neuronal changes in brain edema and increased intracranial pressure. ( 27487831 )
2016
44
Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases. ( 26942067 )
2016
45
Successful treatment with hyperbaric oxygen therapy for severe brain edema characterized by radiological appearance of pseudosubarachnoid hemorrhage in a child. ( 27588084 )
2016
46
Assessment of the Correlations Between Brain Weight and Brain Edema in Experimental Subarachnoid Hemorrhage. ( 26463928 )
2016
47
Magnesium Sulfate Provides Neuroprotection in Eclampsia-Like Seizure Model by Ameliorating Neuroinflammation and Brain Edema. ( 27878553 )
2016
48
Potassium Aspartate Attenuates Brain Injury Induced by Controlled Cortical Impact in Rats Through Increasing Adenosine Triphosphate (ATP) Levels, Na+/K+-ATPase Activity and Reducing Brain Edema. ( 27959885 )
2016
49
Lack of functional P2X7 receptor aggravates brain edema development after middle cerebral artery occlusion. ( 27048203 )
2016
50
Effects of Aquaporin 4 Knockdown on Brain Edema of the Uninjured Side After Traumatic Brain Injury in Rats. ( 27930615 )
2016

Variations for Brain Edema

Expression for Brain Edema

Search GEO for disease gene expression data for Brain Edema.

Pathways for Brain Edema

GO Terms for Brain Edema

Cellular components related to Brain Edema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 ALB ANXA1 AQP1 GLUL IL1B KNG1
2 extracellular region GO:0005576 9.61 ALB ANXA1 IL1B IL6 KNG1 MMP9
3 secretory granule GO:0030141 9.43 IL1B SOD1 VEGFA
4 platelet alpha granule lumen GO:0031093 9.33 ALB KNG1 VEGFA
5 extracellular space GO:0005615 9.32 ALB ANXA1 HMOX1 IL1B IL6 KNG1

Biological processes related to Brain Edema according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 ANXA1 BDKRB2 IL1B IL6 KNG1
2 response to drug GO:0042493 9.8 ANXA1 AQP1 IL6 SLC1A2 SOD1
3 cellular response to hypoxia GO:0071456 9.77 AQP1 HMOX1 VEGFA
4 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.72 AQP1 IL6 VEGFA
5 positive regulation of epithelial cell proliferation GO:0050679 9.7 GLUL IL6 VEGFA
6 positive regulation of T cell proliferation GO:0042102 9.69 ANXA1 IL1B IL6
7 cellular response to hydrogen peroxide GO:0070301 9.67 ANXA1 AQP1 IL6
8 platelet degranulation GO:0002576 9.67 ALB KNG1 SOD1 VEGFA
9 macrophage differentiation GO:0030225 9.61 MMP9 VEGFA
10 embryo implantation GO:0007566 9.61 IL1B MMP9 SOD1
11 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.59 IL1B VEGFA
12 L-glutamate transmembrane transport GO:0089711 9.58 SLC1A2 SLC25A13
13 L-glutamate transport GO:0015813 9.58 SLC1A2 SLC25A13
14 positive regulation of chemokine biosynthetic process GO:0045080 9.57 HMOX1 IL1B
15 myeloid cell homeostasis GO:0002262 9.56 IL6 SOD1
16 positive regulation of angiogenesis GO:0045766 9.56 AQP1 HMOX1 IL1B VEGFA
17 multicellular organismal water homeostasis GO:0050891 9.54 AQP1 AQP4
18 cellular response to cadmium ion GO:0071276 9.5 HMOX1 MMP9 SOD1
19 positive regulation of cell migration GO:0030335 9.48 MMP9 VEGFA
20 positive regulation of apoptotic process GO:0043065 9.43 ANXA1 HMOX1 IL6 KNG1 MMP9 SOD1
21 water transport GO:0006833 9.33 AQP1 AQP4 MIP
22 negative regulation of apoptotic process GO:0043066 9.17 ALB ANXA1 AQP1 IL6 MMP9 SOD1

Molecular functions related to Brain Edema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 L-glutamate transmembrane transporter activity GO:0005313 9.26 SLC1A2 SLC25A13
2 transporter activity GO:0005215 9.26 AQP1 AQP4 MIP SLC25A13
3 water transmembrane transporter activity GO:0005372 9.16 AQP1 AQP4
4 water channel activity GO:0015250 8.8 AQP1 AQP4 MIP

Sources for Brain Edema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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