Aliases & Classifications for Brain Edema

Aliases & Descriptions for Brain Edema:

Name: Brain Edema 12 52 42 14 69
Intracranial Swelling 12
Cerebral Edema 69
Wet Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4724
MeSH 42 D001929
SNOMED-CT 64 2032001 85974009
UMLS 69 C1527311

Summaries for Brain Edema

MalaCards based summary : Brain Edema, also known as intracranial swelling, is related to choroiditis and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, and has symptoms including edema, joint swelling and headache. An important gene associated with Brain Edema is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Folate Metabolism and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Benzocaine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and endothelial, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Brain Edema

Diseases related to Brain Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
id Related Disease Score Top Affiliating Genes
1 choroiditis 29.4 ALB IL1B IL6
2 encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy 12.2
3 encephalopathy, acute, infection-induced, 4 10.8
4 citrullinemia, adult-onset type ii 10.8
5 mitochondrial complex i deficiency due to acad9 deficiency 10.7
6 cerebritis 10.4
7 brain injury 10.4
8 traumatic brain injury 10.3
9 ischemia 10.3
10 ovarian disease 10.2 AQP1 AQP4 VEGFA
11 ischemic optic neuropathy 10.2 ALB IL6 VEGFA
12 ehlers-danlos syndrome, kyphoscoliotic form 10.2 AQP1 AQP4 MIP
13 spinocerebellar ataxia 25 10.2 ALB IL6 VEGFA
14 urethral gland abscess 10.2 AQP1 AQP4 MIP
15 neonatal hypoxic and ischemic brain injury 10.2 AQP4 IL6 MMP9
16 trichomalacia 10.2 AQP4 IL6 MMP9
17 basal cell carcinoma 4 10.2 AQP1 AQP4 MIP
18 leukoplakia of vagina 10.2 IL6 MMP9 VEGFA
19 paranasal sinus sarcoma 10.2 ALB IL6 SLC25A13
20 bipolar i disorder 10.2 IL1B IL6 VEGFA
21 neurological manifestations of pompe disease 10.2 ALB SOD1
22 urticaria 10.2 ALB IL1B KNG1
23 glucosephosphate dehydrogenase deficiency 10.2 ALB IL1B IL6
24 urea cycle disorder 10.2 AQP4 IL1B IL6
25 pituitary infarct 10.2 IL6 MMP9 VEGFA
26 acquired thrombocytopenia 10.2 IL1B IL6 KNG1
27 acute liver failure 10.2
28 exophthalmic ophthalmoplegia 10.2 ALB MMP9 VEGFA
29 mikulicz disease 10.2 ALB IL1B IL6
30 sacrococcygeal teratoma 10.2 KNG1 SOD1 VEGFA
31 congenital chloride diarrhea 10.2 ALB IL6 VEGFA
32 early yaws 10.2 ALB IL1B IL6
33 rift valley fever 10.2 ALB IL1B IL6
34 splenic marginal zone lymphoma 10.2 AQP4 IL6 MMP9
35 uterine corpus cancer 10.2 AQP1 AQP4 IL1B
36 breast apocrine carcinoma in situ 10.2 ALB IL1B IL6
37 anterograde amnesia 10.2 GLUL IL6 VEGFA
38 zellweger syndrome 10.1 ALB HMOX1 VEGFA
39 atrophy of prostate 10.1 AQP1 IL1B IL6
40 spondylolysis 10.1 IL1B IL6 VEGFA
41 colon adenocarcinoma 10.1 ALB IL1B IL6
42 anterior foramen magnum meningioma 10.1 ALB IL1B IL6
43 stickler syndrome, type v 10.1 IL1B IL6 MMP9
44 hepatitis 10.1
45 encephalopathy 10.1
46 proctitis 10.1 ALB IL6 MMP9 VEGFA
47 neonatal jaundice 10.1 AQP4 IL6 MMP9
48 charcot-marie-tooth disease 2a2b 10.1 ALB AQP4 KNG1 MIP VEGFA
49 measles 10.1 IL1B IL6 SOD1
50 toxic optic neuropathy 10.1 IL1B MMP9

Comorbidity relations with Brain Edema via Phenotypic Disease Network (PDN):


Acute Cystitis Brain Cancer
Brain Compression Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Hypertension, Essential

Graphical network of the top 20 diseases related to Brain Edema:



Diseases related to Brain Edema

Symptoms & Phenotypes for Brain Edema

UMLS symptoms related to Brain Edema:


edema, joint swelling, headache

MGI Mouse Phenotypes related to Brain Edema:

44 (show all 17)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.35 AQP1 AQP4 BDKRB2 GLUL HMOX1 IL1B
2 growth/size/body region MP:0005378 10.32 ANXA1 AQP1 AQP4 GLUL HMOX1 IL6
3 behavior/neurological MP:0005386 10.31 AQP1 AQP4 BDKRB2 GLUL HMOX1 IL6
4 cellular MP:0005384 10.29 ALB ANXA1 BDKRB2 GLUL HMOX1 IL6
5 mortality/aging MP:0010768 10.28 HMOX1 IL1B IL6 MMP9 OTC SLC1A2
6 cardiovascular system MP:0005385 10.26 IL1B IL6 MMP9 SOD1 VEGFA ANXA1
7 hematopoietic system MP:0005397 10.24 ANXA1 AQP1 AQP4 BDKRB2 HMOX1 IL1B
8 endocrine/exocrine gland MP:0005379 10.22 ALB ANXA1 AQP1 IL6 OTC SOD1
9 immune system MP:0005387 10.16 ANXA1 AQP4 BDKRB2 HMOX1 IL1B IL6
10 digestive/alimentary MP:0005381 10.08 AQP4 BDKRB2 IL6 MMP9 VEGFA ALB
11 nervous system MP:0003631 10.06 ANXA1 AQP1 AQP4 GLUL IL1B IL6
12 liver/biliary system MP:0005370 10.03 ALB GLUL HMOX1 IL6 OTC SLC25A13
13 renal/urinary system MP:0005367 9.96 ALB AQP1 AQP4 BDKRB2 HMOX1 IL6
14 neoplasm MP:0002006 9.91 IL1B IL6 MMP9 SOD1 VEGFA ALB
15 reproductive system MP:0005389 9.76 AQP1 BDKRB2 HMOX1 IL6 MMP9 OTC
16 skeleton MP:0005390 9.56 ANXA1 AQP1 BDKRB2 IL1B IL6 MMP9
17 vision/eye MP:0005391 9.17 AQP1 AQP4 IL6 MIP MMP9 SOD1

Drugs & Therapeutics for Brain Edema

Drugs for Brain Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 381)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4,Phase 2,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
2
Zinc Approved Phase 4,Phase 1 7440-66-6 32051 23994
3
Furosemide Approved, Vet_approved Phase 4,Phase 3 54-31-9 3440
4
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
5
Metolazone Approved Phase 4 17560-51-9 4170
6
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 453 6251
7
Temozolomide Approved, Investigational Phase 4,Phase 3,Phase 2 85622-93-1 5394
8
Acetazolamide Approved, Vet_approved Phase 4,Phase 2 59-66-5 1986
9
Progesterone Approved, Vet_approved Phase 4,Phase 1,Phase 2 57-83-0 5994
10
Rizatriptan Approved Phase 4 145202-66-0, 144034-80-0 5078
11
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
12
Selegiline Approved, Investigational, Vet_approved Phase 4 14611-51-9 26757 5195
13
Tolvaptan Approved Phase 4,Phase 3 150683-30-0 216237
14
Dacarbazine Approved, Investigational Phase 4,Phase 2 4342-03-4 5351166
15
Conivaptan Approved, Investigational Phase 4,Phase 2,Phase 1 210101-16-9 151171
16
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
17 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 1,Early Phase 1
18
Choline Approved, Nutraceutical Phase 4 62-49-7 305
19 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1
20 insulin Phase 4,Phase 1
21 Insulin, Globin Zinc Phase 4,Phase 1
22 Antihypertensive Agents Phase 4,Phase 3,Phase 2
23 diuretics Phase 4,Phase 3,Phase 2,Phase 1
24 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Sodium Chloride Symporter Inhibitors Phase 4
26 Sodium Potassium Chloride Symporter Inhibitors Phase 4
27 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
28 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Early Phase 1
32 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Neuroprotective Agents Phase 4,Phase 2,Phase 3
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 Protective Agents Phase 4,Phase 3,Phase 2
36 Alkylating Agents Phase 4,Phase 3,Phase 2
37 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2
38 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
39 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
40 Anticonvulsants Phase 4,Phase 3,Phase 2
41 Carbonic Anhydrase Inhibitors Phase 4
42 Progestins Phase 4,Phase 1,Phase 2
43 Torsemide Phase 4
44
Serotonin Phase 4 50-67-9 5202
45 Serotonin Agents Phase 4
46 Antiparkinson Agents Phase 4
47 Dopamine Agents Phase 4,Phase 3,Phase 2
48 Dopamine agonists Phase 4,Phase 3,Phase 2
49 Arginine Vasopressin Phase 4,Phase 3,Phase 2,Phase 1
50 Vasopressins Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 244)
id Name Status NCT ID Phase
1 Normoglycemia and Neurological Outcome Unknown status NCT01137773 Phase 4
2 A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients Unknown status NCT00690521 Phase 4
3 Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy Completed NCT02037815 Phase 4
4 Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing Completed NCT01993667 Phase 4
5 Does Oral Micronized Progesterone Shorten Time of Symptoms From Concussion Completed NCT01809639 Phase 4
6 Effect of a New Formulation of Torasemide (Prolonged Release)on Myocardial Fibrosis in Patients With Heart Failure. Completed NCT00409942 Phase 4
7 Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms. Completed NCT00753311 Phase 4
8 Efficacy of Orally Disintegrating Selegiline in Parkinson's Patients Experiencing Adverse Effects With Dopamine Agonists Completed NCT00443872 Phase 4
9 Effect of Tolvaptan on Mid- to Long-term Prognosis of Heart Failure Patients Completed NCT01439009 Phase 4
10 A Post Marketing Surveillance Study for NutropinAq® in Adults With Growth Hormone Deficiency Completed NCT00455884 Phase 4
11 Intravitreal Aflibercept Injection for the Treatment of Submacular Vascularized Pigment Epithelial Detachment Completed NCT01722656 Phase 4
12 Supra-early Post-Surgery Chemotherapy in the Treatment on GBM Patients Recruiting NCT02520635 Phase 4
13 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS) Recruiting NCT02529475 Phase 4
14 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT01763853 Phase 4
15 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03046693 Phase 4
16 Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease Recruiting NCT02530931 Phase 4
17 Evaluation of Fluid Retention Due to Superpotent Topical Corticosteroid Recruiting NCT02360202 Phase 4
18 NT-proBNP and New Biomarkers in Patients With Dyspnea and/or Peripheral Edema Active, not recruiting NCT00143793 Phase 4
19 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
20 Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients Terminated NCT00727090 Phase 4
21 Use of Nesiritide in the Management of Acute Diastolic Heart Failure Terminated NCT00083772 Phase 4
22 The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients Withdrawn NCT01526876 Phase 4
23 Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal EF Withdrawn NCT00505791 Phase 4
24 Randomized Trial of Erythropoietin During Cerebral Malaria Unknown status NCT00697164 Phase 2, Phase 3
25 High Dose Hyperoncotic Serum Albumin for the Treatment of the Acute Phase of Severe Head Injury Unknown status NCT00152685 Phase 2, Phase 3
26 Clinical Value of Noninvasive Intracranial Pressure Measurement Unknown status NCT02130219 Phase 2, Phase 3
27 Treatment of Acute Stroke With Cromolyn(Single Dose) Unknown status NCT01175525 Phase 3
28 XERECEPT® (hCRF) for Patients Requiring Dexamethasone to Treat Edema Associated With Brain Tumors Completed NCT00088166 Phase 3
29 An Open-Labeled, Extended-Use of XERECEPT (hCRF) for Patients in Studies NTI 0302, 0303, or Other Designated Studies Completed NCT00226655 Phase 3
30 Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis Completed NCT01365793 Phase 3
31 Effect of Tolvaptan on Cognitive Function in Cirrhosis Completed NCT01556646 Phase 3
32 Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness Completed NCT00664001 Phase 3
33 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Completed NCT00619203 Phase 3
34 Continuous Positive Airway Pressure for Acute Pulmonary Edema Completed NCT00554580 Phase 3
35 Non-Invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema: a Multicentre Study Completed NCT00785174 Phase 3
36 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3
37 Vinpocetine Inhibits NF-κB-dependent Inflammation in Acute Ischemic Stroke Patients Completed NCT02878772 Phase 2, Phase 3
38 Impact of Switching to Continuous Release Dopamine Agonists Completed NCT00465452 Phase 3
39 An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain Completed NCT01202227 Phase 3
40 Early Coronary Angiography Versus Delayed Coronary Angiography Recruiting NCT02387398 Phase 2, Phase 3
41 Safety and Efficacy of Alteplase When Administered in Chinese Patients With Acute Ischemic Hemispheric Stroke Where Thrombolysis is Initiated Between 3 and 4.5 Hours After Stroke Onset Recruiting NCT02930837 Phase 3
42 Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma Active, not recruiting NCT01805453 Phase 3
43 Neuromonitoring in Patients During Aortic Valve Replacement Enrolling by invitation NCT02697786 Phase 3
44 Early Induced Hypernatremia for the Prevention and Management of Brain Edema Not yet recruiting NCT02798601 Phase 3
45 CIRARA in Large Hemispheric Infarction Analyzing Modified Rankin Scale (mRS) and Mortality (CHARM) Not yet recruiting NCT02864953 Phase 3
46 Prevention of Epileptic Seizures in Acute intraCerebral Haemorrhage Not yet recruiting NCT02631759 Phase 3
47 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3
48 Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts Terminated NCT00190203 Phase 3
49 Induced Hypertension for Treatment of Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage Terminated NCT01613235 Phase 3
50 Albumin in Acute Ischemic Stroke Trial Terminated NCT00235495 Phase 3

Search NIH Clinical Center for Brain Edema

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: brain edema

Genetic Tests for Brain Edema

Anatomical Context for Brain Edema

MalaCards organs/tissues related to Brain Edema:

39
Brain, Liver, Endothelial, Lung, Bone, Myeloid, Prostate

Publications for Brain Edema

Articles related to Brain Edema:

(show top 50) (show all 628)
id Title Authors Year
1
Brain edema with clasmatodendrosis complicating ataxia telangiectasia. ( 28351596 )
2017
2
Simulating vasogenic brain edema using chronic VEGF infusion. ( 28059647 )
2017
3
Mathematical model in post-mortem estimation of brain edema using morphometric parameters. ( 27914998 )
2017
4
Lack of functional P2X7 receptor aggravates brain edema development after middle cerebral artery occlusion. ( 27048203 )
2016
5
Mechanism and Therapy of Brain Edema after Intracerebral Hemorrhage. ( 27110940 )
2016
6
Brain edema: a valid endpoint for measuring hepatic encephalopathy? ( 27272740 )
2016
7
Central Role of Maladapted Astrocytic Plasticity in Ischemic Brain Edema Formation. ( 27242440 )
2016
8
Brain Edema after Repeat Gamma Knife Radiosurgery for a Large Arteriovenous Malformation: A Case Report. ( 27574486 )
2016
9
The Effects of Stereotactic Cerebroventricular Administration of Albumin, Mannitol, Hypertonic Sodium Chloride, Glycerin and Dextran in Rats with Experimental Brain Edema. ( 27593830 )
2016
10
Vasopressin Hypersecretion-Associated Brain Edema Formation in Ischemic Stroke: Underlying Mechanisms. ( 27068863 )
2016
11
Tongxinluo reduces brain edema and inhibits post-ischemic inflammation after middle cerebral artery occlusion in rats. ( 26805468 )
2016
12
Quantitative analysis of brain edema in patients with malignant glioma treated with BCNU wafers. ( 27452129 )
2016
13
Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na(+)/H(+) exchanger 1 expression. ( 26724742 )
2016
14
Alpha-Tocopherol Reduces Brain Edema and Protects Blood - Brain Barrier Integrity Following Focal Cerebral Ischemia in Rats. ( 27606423 )
2016
15
Valproic Acid Pretreatment Reduces Brain Edema in a Rat Model of Surgical Brain Injury. ( 26463966 )
2016
16
Glucocorticoids in the management of peritumoral brain edema: a review of molecular mechanisms. ( 27613642 )
2016
17
Human neuronal changes in brain edema and increased intracranial pressure. ( 27487831 )
2016
18
The influence of carmustine wafer implantation on tumor bed cysts and peritumoral brain edema. ( 27430412 )
2016
19
Vascular Endothelial Growth Factor in Brain Edema Formation After Subarachnoid Hemorrhage. ( 26463944 )
2016
20
Effects of Gender and Estrogen Receptors on Iron-Induced Brain Edema Formation. ( 26463972 )
2016
21
YiQiFuMai powder injection ameliorates blood-brain barrier dysfunction and brain edema after focal cerebral ischemia-reperfusion injury in mice. ( 26834461 )
2016
22
Overexpression of caveolin-1 attenuates brain edema by inhibiting tight junction degradation. ( 27708218 )
2016
23
Automated assessment of early hypoxic brain edema in non-enhanced CT predicts outcome in patients after cardiac arrest. ( 27036663 )
2016
24
A fatal adverse effect of cefazolin administration: severe brain edema in a patient with multiple meningiomas. ( 26929668 )
2016
25
Assessment of the Correlations Between Brain Weight and Brain Edema in Experimental Subarachnoid Hemorrhage. ( 26463928 )
2016
26
To retain or remove the bone flap during evacuation of acute subdural hematoma: factors associated with perioperative brain edema. ( 27476687 )
2016
27
Effects of Different Doses of Levetiracetam on Aquaporin 4 Expression in Rats with Brain Edema Following Fluid Percussion Injury. ( 26927633 )
2016
28
Effects of metformin treatment on glioma-induced brain edema. ( 27648126 )
2016
29
Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases. ( 26942067 )
2016
30
Erratum to: Lack of functional P2X7 receptor aggravates brain edema development after middle cerebral artery occlusion. ( 27826687 )
2016
31
Significance of Primary Tumor Location and Histology for Brain Metastasis Development and Peritumoral Brain Edema in Lung Cancer. ( 27562339 )
2016
32
I^-Dystroglycan cleavage by matrix metalloproteinase-2/-9 disturbs aquaporin-4 polarization and influences brain edema in acute cerebral ischemia. ( 27038751 )
2016
33
Correlation Between Subacute Sensorimotor Deficits and Brain Edema in Rats after Surgical Brain Injury. ( 26463968 )
2016
34
Unfractionated heparin after TBI reduces in vivo cerebrovascular inflammation, brain edema and accelerates cognitive recovery. ( 27533909 )
2016
35
Curcumin alleviates brain edema by lowering AQP4 expression levels in a rat model of hypoxia-hypercapnia-induced brain damage. ( 26997983 )
2016
36
Failed First Craniotomy and Tumor Removal of Parasagittal Meningioma with Severe Peritumoral Brain Edema. ( 27867923 )
2016
37
Fluid Intake Related to Brain Edema in Acute Middle Cerebral Artery Infarction. ( 26666449 )
2016
38
Successful treatment with hyperbaric oxygen therapy for severe brain edema characterized by radiological appearance of pseudosubarachnoid hemorrhage in a child. ( 27588084 )
2016
39
The role of extracellular-5'-nucleotidase/CD73 in glioma peritumoural brain edema. ( 26884147 )
2016
40
Potassium Aspartate Attenuates Brain Injury Induced by Controlled Cortical Impact in Rats Through Increasing Adenosine Triphosphate (ATP) Levels, Na+/K+-ATPase Activity and Reducing Brain Edema. ( 27959885 )
2016
41
Hydrogen sulfide attenuates brain edema in early brain injury after subarachnoid hemorrhage in rats: Possible involvement of MMP-9 induced blood-brain barrier disruption and AQP4 expression. ( 27080433 )
2016
42
The Role of Matricellular Proteins in Brain Edema after Subarachnoid Hemorrhage. ( 26463940 )
2016
43
Src Family Kinases in Brain Edema After Acute Brain Injury. ( 26463946 )
2016
44
Peritumoral Brain Edema in Meningiomas Depends on Aquaporin-4 Expression and Not on Tumor Grade, Tumor Volume, Cell Count, or Ki-67 Labeling Index. ( 27552812 )
2016
45
Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I/R. ( 26686249 )
2016
46
Clinical Outcomes of Wulingsan Subtraction Decoction Treatment of Postoperative Brain Edema and Fever as a Complication of Glioma Neurosurgery. ( 27019661 )
2016
47
Brain Edema After Ischaemic Stroke. ( 27994292 )
2016
48
Effect of estrogen and/or progesterone administration on traumatic brain injury-caused brain edema: the changes of aquaporin-4 and interleukin-6. ( 26638215 )
2016
49
TRPV4 channels mediate Na-K-Cl-co-transporter-induced brain edema after traumatic brain injury. ( 27926982 )
2016
50
Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema. ( 27074570 )
2016

Variations for Brain Edema

Expression for Brain Edema

Search GEO for disease gene expression data for Brain Edema.

Pathways for Brain Edema

Pathways related to Brain Edema according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.13 ALB IL1B IL6 SOD1
2 11.97 AQP4 IL1B IL6 VEGFA
3 11.88 HMOX1 IL1B MMP9 VEGFA
4 11.78 IL1B IL6 MMP9
5 11.72 IL1B IL6 VEGFA
6 11.71 HMOX1 IL6 VEGFA
7 11.65 IL1B IL6 VEGFA
8 11.51 ANXA1 AQP1 AQP4 IL1B IL6 MMP9
9 11.36 HMOX1 IL1B IL6 MMP9
10 11.33 IL6 KNG1 MMP9
11
Show member pathways
11.26 IL1B IL6 MMP9 VEGFA
12 11.16 ANXA1 HMOX1 IL1B IL6 MMP9 VEGFA
13 11.12 HMOX1 IL1B IL6
14 11.09 IL1B IL6 SOD1
15 11.03 HMOX1 IL6 MMP9
16 10.73 IL1B IL6
17
Show member pathways
10.41 GLUL SLC1A2

GO Terms for Brain Edema

Cellular components related to Brain Edema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 9.33 IL1B SOD1 VEGFA
2 extracellular space GO:0005615 9.28 ALB ANXA1 HMOX1 IL1B IL6 KNG1
3 platelet alpha granule lumen GO:0031093 9.13 ALB KNG1 VEGFA

Biological processes related to Brain Edema according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 ANXA1 BDKRB2 IL1B IL6 KNG1
2 cellular response to hypoxia GO:0071456 9.77 AQP1 HMOX1 VEGFA
3 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.71 AQP1 IL6 VEGFA
4 platelet degranulation GO:0002576 9.71 ALB KNG1 SOD1 VEGFA
5 positive regulation of epithelial cell proliferation GO:0050679 9.7 GLUL IL6 VEGFA
6 positive regulation of T cell proliferation GO:0042102 9.69 ANXA1 IL1B IL6
7 cellular response to hydrogen peroxide GO:0070301 9.67 ANXA1 AQP1 IL6
8 response to nutrient levels GO:0031667 9.65 IL6 OTC SOD1
9 positive regulation of apoptotic process GO:0043065 9.63 ANXA1 HMOX1 IL6 KNG1 MMP9 SOD1
10 positive regulation of angiogenesis GO:0045766 9.62 AQP1 HMOX1 IL1B VEGFA
11 macrophage differentiation GO:0030225 9.61 MMP9 VEGFA
12 embryo implantation GO:0007566 9.61 IL1B MMP9 SOD1
13 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.59 IL1B VEGFA
14 L-glutamate transmembrane transport GO:0089711 9.58 SLC1A2 SLC25A13
15 L-glutamate transport GO:0015813 9.58 SLC1A2 SLC25A13
16 positive regulation of chemokine biosynthetic process GO:0045080 9.57 HMOX1 IL1B
17 myeloid cell homeostasis GO:0002262 9.56 IL6 SOD1
18 multicellular organismal water homeostasis GO:0050891 9.55 AQP1 AQP4
19 cellular response to cadmium ion GO:0071276 9.54 HMOX1 MMP9 SOD1
20 water transport GO:0006833 9.43 AQP1 AQP4 MIP
21 response to drug GO:0042493 9.43 ANXA1 AQP1 IL6 OTC SLC1A2 SOD1
22 negative regulation of apoptotic process GO:0043066 9.17 ALB ANXA1 AQP1 IL6 MMP9 SOD1

Molecular functions related to Brain Edema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 L-glutamate transmembrane transporter activity GO:0005313 9.26 SLC1A2 SLC25A13
2 transporter activity GO:0005215 9.26 AQP1 AQP4 MIP SLC25A13
3 water transmembrane transporter activity GO:0005372 9.16 AQP1 AQP4
4 water channel activity GO:0015250 8.8 AQP1 AQP4 MIP

Sources for Brain Edema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....