MCID: BRN004
MIFTS: 53

Brain Edema malady

Neuronal diseases category

Summaries for Brain Edema

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Cerebral edema or cerebral oedema is excess accumulation of fluid in the intracellular or extracellular... more...

MalaCards: Brain Edema, also known as intracranial swelling, is related to ischemia and hepatic encephalopathy. An important gene associated with Brain Edema is AQP4 (aquaporin 4), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Regulation of Water Balance by Renal Aquaporins. The drugs dexamethasone and dexamethasone acetate and the compounds fr173657 and fr190997 have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and endothelial, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Aliases & Classifications for Brain Edema

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain edema 9 11 46 63
intracranial swelling 9
wet brain 9


External Ids:

Disease Ontology9 DOID:4724
SNOMED-CT59 85974009, 2032001
MeSH36 D001929

Related Diseases for Brain Edema

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Brain Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.8SOD1, AQP4, MIP, KNG1, GLUL, BDKRB2
2hepatic encephalopathy30.7GLUL, AQP4
3cerebrovascular disease29.8AQP4, MIP, BDKRB2, OTC
4astrocytoma29.8BDKRB2, GLUL, KNG1, AQP4
5cerebritis10.9
6brain injury10.8
7traumatic brain injury10.7
8meningioma10.7
9acute liver failure10.7
10hepatitis10.6
11neuronitis10.5
12endotheliitis10.5
13cerebral artery occlusion10.5
14meningitis10.4
15hypertension10.4
16hypoxia10.4
17pneumococcal meningitis10.3
18diabetic ketoacidosis10.3
19intracranial hypertension10.3
20benign meningioma10.2
21arteriovenous malformation10.2
22middle cerebral artery infarction10.2
23head injury10.2
24burns10.1
25cerebral malaria10.1
26liver disease10.1
27malaria10.1
28nephrogenic diabetes insipidus10.1AQP4
29diabetic cataract10.1MIP
30menieres disease10.1MIP
31wernicke-korsakoff syndrome10.1
32stroke, ischemic10.0KNG1, AQP4
33senile cataract10.0MIP, SOD1
34hyperhomocysteinemia10.0SOD1, KNG1
35hereditary angioedema10.0BDKRB2, KNG1
36wilson disease10.0OTC, SOD1
37chronic granulomatous disease10.0SOD1, OTC
38brain disease10.0OTC, AQP4
39angioedema10.0KNG1, BDKRB2
40pancreatitis10.0KNG1, SOD1
41congestive heart failure10.0KNG1, MIP
42bronchitis10.0KNG1, BDKRB2
43coronary artery disease10.0KNG1, SOD1
44acute intermittent porphyria10.0SOD1, GLUL
45temporal lobe epilepsy10.0GLUL, AQP4
46reye syndrome10.0GLUL, OTC
47cataract10.0SOD1, MIP
48glaucoma10.0AQP4, MIP
49duchenne muscular dystrophy10.0OTC, MIP, AQP4
50vascular disease10.0OTC, KNG1, SOD1

Graphical network of the top 20 diseases related to Brain Edema:



Diseases related to brain edema

Symptoms for Brain Edema

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Drugs & Therapeutics for Brain Edema

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Brain Edema

Drug clinical trials:

Search ClinicalTrials for Brain Edema

Search NIH Clinical Center for Brain Edema

Search CenterWatch for Brain Edema

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Brain Edema

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Anatomical Context for Brain Edema

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Sources:
34MalaCards
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MalaCards organs/tissues related to Brain Edema:

34
Brain, Liver, Endothelial, Lung, Myeloid, Prostate

Animal Models for Brain Edema or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Brain Edema:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2SOD1, AQP4, BDKRB2, OTC
2MP:00107687.7OTC, BDKRB2, GLUL, AQP4, SOD1
3MP:00053867.6SOD1, AQP4, GLUL, BDKRB2, OTC
4MP:00053767.3OTC, BDKRB2, GLUL, KNG1, AQP4, SOD1

Publications for Brain Edema

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Sources:
53PubMed
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Articles related to Brain Edema:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Reduction of brain edema and expression of aquaporins with acute ethanol treatment after traumatic brain injury. (23198799)
2013
2
Volumetric electromagnetic phase-shift spectroscopy of brain edema and hematoma. (23691001)
2013
3
The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury. (24346689)
2013
4
Baicalin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage. (23974988)
2013
5
Extent of peritumoral brain edema correlates with prognosis, tumoral growth pattern, HIF1a expression and angiogenic activity in patients with single brain metastases. (23076770)
2013
6
Modern approach in therapy of brain edema in cerebral ischemia. (22926391)
2012
7
Measurement of brain edema by noninvasive cerebral electrical impedance in patients with massive hemispheric cerebral infarction. (23095732)
2012
8
Minimally invasive procedures for evacuation of intracerebral hemorrhage reduces perihematomal glutamate content, blood-brain barrier permeability and brain edema in rabbits. (21161434)
2011
9
Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivative. (21552121)
2011
10
The influence of benzamil hydrochloride on the evolution of hyponatremic brain edema as assessed by in vivo MRI study in rats. (21445679)
2011
11
Pentoxifylline attenuates TNF-I+ protein levels and brain edema following temporary focal cerebral ischemia in rats. (21219888)
2011
12
The role of hypoxia-inducible factor-1I+, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury. (20617879)
2011
13
Diabetes aggravates nanoparticles induced breakdown of the blood-brain barrier permeability, brain edema formation, alterations in cerebral blood flow and neuronal injury. An experimental study using physiological and morphological investigations in the rat. (21121280)
2010
14
Effect of sex steroid hormones on brain edema, intracranial pressure, and neurologic outcomes after traumatic brain injury. (20555409)
2010
15
Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage. (20132873)
2010
16
Dietary virgin olive oil reduces blood brain barrier permeability, brain edema, and brain injury in rats subjected to ischemia-reperfusion. (20602077)
2010
17
Radiation exposure prior to ischemia decreases lesion volume, brain edema and cell death. (19812920)
2010
18
Brain expression of the water channels aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema. (20938728)
2010
19
Subtle BBB alterations in brain edema associated with acute liver failure. (20201130)
2010
20
Delayed enlargement of brain edema after resection of intracranial meningioma: two case reports. (19855147)
2009
21
Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline. (19220703)
2009
22
Hypothermia attenuates oxidative/nitrosative stress, encephalopathy and brain edema in acute (ischemic) liver failure. (19428816)
2009
23
Prior ethanol injection promotes brain edema after traumatic brain injury. (19558208)
2009
24
Liposome-encapsulated hemoglobin alleviates brain edema after permanent occlusion of the middle cerebral artery in rats. (19178460)
2009
25
Serum S100B, brain edema, and hematoma formation in a rat model of collagenase-induced hemorrhagic stroke. (19027832)
2009
26
Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury. (19436311)
2009
27
Correlation of macrophage inflammatory protein-2 expression and brain edema in rats after intracerebral hemorrhage. (18830379)
2009
28
MR imaging-based evidence of vasogenic brain edema in a case of acute acetone intoxication. (18202235)
2008
29
Brain edema in acute liver failure: can it be prevented? Can it be treated? (17316881)
2007
30
A review of progress in understanding the pathophysiology and treatment of brain edema. (17613227)
2007
31
Matrix metalloproteinase inhibition attenuates brain edema in an in vivo model of surgically-induced brain injury. (18091283)
2007
32
Midline-shift corresponds to the amount of brain edema early after hemispheric stroke--an MRI study in rats. (17413996)
2007
33
Protective effect of the V1a receptor antagonist SR49059 on brain edema formation following middle cerebral artery occlusion in the rat. (16671476)
2006
34
The pathophysiology of brain edema in acute liver failure. (15961187)
2005
35
Effects of magnesium sulfate on traumatic brain edema in rats. (15294111)
2004
36
The relationship between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in intracranial meningiomas. (15662977)
2004
37
Hyperammonemia, brain edema and blood-brain barrier alterations in prehepatic portal hypertensive rats and paracetamol intoxication. (15112350)
2004
38
Brain edema -- a new classification. (12781651)
2003
39
Therapeutical efficacy of a novel non-peptide bradykinin B2 receptor antagonist on brain edema formation and ischemic tissue damage in focal cerebral ischemia. (14753436)
2003
40
Antioxidant compounds EGB-761 and BN-52021 attenuate brain edema formation and hemeoxygenase expression following hyperthermic brain injury in the rat. (14753460)
2003
41
Long-term hypothermia in patients with severe brain edema after poor-grade subarachnoid hemorrhage: feasibility and intensive care complications. (12826972)
2003
42
Experimental intracerebral hemorrhage: effect of lysed erythrocytes on brain edema and blood-brain barrier permeability. (12168318)
2002
43
Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist. (11596963)
2001
44
The effect of treatment with albumin, hetastarch, or hypertonic saline on neurological status and brain edema in a rat model of closed head trauma combined with uncontrolled hemorrhage and concurrent resuscitation in rats. (11226099)
2001
45
ONTARIO. Congenital brain edema in 2 Hereford calves. (17424613)
2000
46
Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. (10701532)
2000
47
The synergistic effect of acute subdural hematoma combined with diffuse traumatic brain injury on brain edema. (11450010)
2000
48
Role of hydrodynamic processes in the pathogenesis of peritumoral brain edema in meningiomas. (11014537)
2000
49
Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats. (10942013)
2000
50
Neurotropin treatment of brain edema accompanying acute middle cerebral artery infarction. (7976582)
1994

Variations for Brain Edema

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Expression for genes affiliated with Brain Edema

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Edema

Search GEO for disease gene expression data for Brain Edema.

Pathways for genes affiliated with Brain Edema

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Sources:
51PathCards, 56Reactome, 61Thomson Reuters, 31KEGG, 39NCBI BioSystems Database, 52PharmGKB
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Pathways related to Brain Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6KNG1, SOD1
2
Show member pathways
9.6AQP4, MIP
3
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.4KNG1, BDKRB2
4
Show member pathways
9.4BDKRB2, KNG1
5
Show member pathways
citrulline-nitric oxide cycle39
arginine degradation I (arginase pathway)39
proline degradation39
glutamine degradation I39
proline biosynthesis I39
superpathway of citrulline metabolism39
proline biosynthesis II (from arginine)39
citrulline biosynthesis39
arginine degradation VI (arginase 2 pathway)39
Urea cycle and metabolism of amino groups39
asparagine biosynthesis I39
4-hydroxyproline degradation I39
citrulline degradation39
9.1GLUL, OTC

Compounds for genes affiliated with Brain Edema

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Sources:
46Novoseek, 30IUPHAR, 62Tocris Bioscience, 12DrugBank, 25HMDB, 52PharmGKB
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Compounds related to Brain Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1fr17365746 3010.9KNG1, BDKRB2
2fr19099746 3010.9KNG1, BDKRB2
3cereport469.9KNG1, BDKRB2
4lys-[des-arg9]bradykinin629.9KNG1, BDKRB2
5win 64338 hydrochloride629.9BDKRB2, KNG1
6benzoate469.9SOD1, OTC
7r 715629.9KNG1, BDKRB2
8hoe 140629.8KNG1, BDKRB2
9quinaprilat469.8KNG1, BDKRB2
10mercury469.8AQP4, MIP
11des-arg(10)-kallidin469.8BDKRB2, KNG1
12ramiprilat469.8BDKRB2, KNG1
13icatibant46 30 1211.8BDKRB2, KNG1
14kallidin46 3010.8KNG1, BDKRB2
15bradykinin62 30 2511.8BDKRB2, KNG1
16enalaprilat469.8BDKRB2, KNG1
17mepyramine46 1210.7KNG1, BDKRB2
18lisinopril46 52 25 1212.7BDKRB2, KNG1
19nitroglycerin46 1210.7KNG1, SOD1
20allopurinol46 52 1211.7SOD1, OTC
21candesartan46 52 30 1212.6KNG1, BDKRB2
22citrulline46 2510.5SOD1, OTC, KNG1
23mannitol46 1210.5SOD1, AQP4, MIP
24captopril46 62 52 30 1213.4KNG1, BDKRB2
25tetraethylammonium46 30 1211.4KNG1, MIP
26n(g)-nitro-l-arginine methyl ester469.4SOD1, KNG1, BDKRB2
27ng-nitro-l-arginine469.4BDKRB2, SOD1, KNG1
28l-nmma469.4BDKRB2, KNG1, SOD1
29carbamoyl phosphate469.4GLUL, OTC
30sodium nitroprusside469.3BDKRB2, SOD1, KNG1
31potassium46 25 1211.3MIP, KNG1, AQP4
32histamine46 30 2511.2BDKRB2, KNG1, AQP4
33indomethacin46 30 62 1212.2BDKRB2, KNG1, SOD1
34phosphoenolpyruvate46 1210.1GLUL, OTC
35ammonium469.0GLUL, OTC, MIP
36chloride469.0AQP4, GLUL, MIP
37malate468.8OTC, GLUL
38urea46 25 1210.7AQP4, GLUL, OTC, MIP
39glycerol46 25 1210.7OTC, GLUL, MIP, AQP4
40proline468.6BDKRB2, GLUL, MIP
41lactate468.5OTC, SOD1, MIP, GLUL
42dexamethasone46 52 30 1211.4GLUL, MIP, BDKRB2, AQP4
43creatinine468.4SOD1, GLUL, BDKRB2, OTC
44cysteine468.1SOD1, AQP4, MIP, GLUL, BDKRB2
45atp46 309.0KNG1, OTC, BDKRB2, GLUL, MIP
46lipid467.9MIP, OTC, GLUL, BDKRB2, SOD1
47sodium46 258.7OTC, KNG1, AQP4, MIP, GLUL, BDKRB2
48glutamate467.6BDKRB2, SOD1, AQP4, MIP, GLUL, OTC
49arginine467.6OTC, KNG1, BDKRB2, SOD1, MIP, GLUL
50nitric oxide46 25 129.6BDKRB2, SOD1, KNG1, MIP, OTC, GLUL

GO Terms for genes affiliated with Brain Edema

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Sources:
17Gene Ontology
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Cellular components related to Brain Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.5GLUL, AQP4, SOD1
2plasma membraneGO:0058868.1BDKRB2, KNG1, MIP, AQP4, SOD1

Biological processes related to Brain Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vasodilationGO:0423119.5BDKRB2, KNG1
2water transportGO:0068339.5AQP4, MIP
3smooth muscle contractionGO:0069399.4BDKRB2, KNG1
4positive regulation of cytosolic calcium ion concentrationGO:0072049.4BDKRB2, KNG1
5platelet degranulationGO:0025769.3KNG1, SOD1

Products for genes affiliated with Brain Edema

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brain Edema

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet