MCID: BRN004
MIFTS: 57

Brain Edema malady

Neuronal diseases category

Summaries for Brain Edema

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Cerebral edema or cerebral œdema is excess accumulation of fluid in the intracellular or extracellular... more...

MalaCards: Brain Edema, also known as intracranial swelling, is related to ischemia and acute liver failure. An important gene associated with Brain Edema is AQP4 (aquaporin 4), and among its related pathways are Passive Transport by Aquaporins and Complement and coagulation cascades. The drugs dexamethasone and mannitol and the compounds mannitol and cereport have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and endothelial, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Aliases & Classifications for Brain Edema

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain edema 8 10 44 60
intracranial swelling 8
wet brain 8


External Ids:

Disease Ontology8 DOID:4724
SNOMED-CT56 2032001, 85974009
MeSH34 D001929

Related Diseases for Brain Edema

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Brain Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia31.0AQP4, GFAP, GLUL, MIP, OXA1L, KNG1
2acute liver failure31.0TSPO, OTC
3meningioma30.9GFAP, GLUL
4hepatitis30.8OTC
5hepatic encephalopathy30.6GLUL, SLC25A13, TSPO, AQP4
6hypertension30.5KNG1
7stroke, ischemic30.4AQP4, TSPO
8brain disease30.4SLC25A13, OTC, TSPO, AQP4
9influenza29.9KNG1, OXA1L
10uremia29.9SOD1, AGER, OXA1L
11brain cancer29.9AQP4, TSPO, GFAP, MIP, BDKRB2
12hydrocephalus29.9AQP4, AQP1
13prostate cancer29.9BDKRB2, KNG1, AGER, ANXA1, OXA1L, TSPO
14astrocytoma29.9BDKRB2, KNG1, GLUL, GFAP, TSPO, AQP1
15cerebritis10.9
16brain meningioma10.7
17neuronitis10.5
18cerebral artery occlusion10.4
19meningitis10.4
20brain glioma10.3
21diabetic ketoacidosis10.2
22middle cerebral artery infarction10.2
23hepatitis a10.2
24intracranial hypertension10.2
25arteriovenous malformation10.2
26benign meningioma10.2
27burns10.1
28cerebral malaria10.1
29liver disease10.1
30malaria10.1
31transient cerebral ischemia10.1
32wernicke-korsakoff syndrome10.0
33migraine10.0OXA1L
34peritonitis10.0AQP1
35maple syrup urine disease10.0OTC
36menieres disease10.0MIP
37pancreatitis10.0KNG1, SOD1
38lung cancer10.0SLC5A7
39eye disease10.0TSPO
40acute pancreatitis10.0SOD1
41myeloma10.0GLUL, OXA1L
42hypercholesterolemia10.0KNG1
43diabetic retinopathy10.0AGER, SOD1
44encephalomyelitis10.0AQP4
45myopathy10.0ANXA1, GLUL
46cholera10.0OXA1L, KNG1
47pneumonia10.0MIP, OXA1L, KNG1
48hereditary angioedema10.0KNG1, BDKRB2
49anaplastic astrocytoma10.0GFAP
50fibromyalgia10.0TSPO

Graphical network of the top 20 diseases related to Brain Edema:



Diseases related to brain edema

Clinical Features for Brain Edema

About this section

Drugs & Therapeutics for Brain Edema

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Brain Edema

Drug clinical trials:

Search ClinicalTrials for Brain Edema

Search NIH Clinical Center for Brain Edema

Search CenterWatch for Brain Edema

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Brain Edema

About this section

Anatomical Context for Brain Edema

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Brain Edema:

32
Brain, Liver, Endothelial, Lung, Heart, Myeloid, Prostate

Animal Models for Brain Edema or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Brain Edema

About this section
Sources:
50PubMed
See all sources

Articles related to Brain Edema:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Ischemic postconditioning decreases cerebral edema and brain blood barrier disruption caused by relief of carotid stenosis in a rat model of cerebral hypoperfusion. (23469092)
2013
2
Expression of aquaporin 5 and the AQP5 polymorphism A(-1364)C in association with peritumoral brain edema in meningioma patients. (23392848)
2013
3
Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation. (22782669)
2012
4
Invasive pressure monitoring saves from tuberculous meningitis with fulminant generalized brain edema. (22110466)
2011
5
The Na-K-Cl cotransporter in the brain edema of acute liver failure. (21056502)
2011
6
Role of aquaporins in cell migration and edema formation in human brain tumors. (21784068)
2011
7
Increased blood-brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: role of lipid peroxidation and calpain-1/2, matrix metalloproteinase-2/9, and RhoA overactivation. (21836084)
2011
8
Effect of sex steroid hormones on brain edema, intracranial pressure, and neurologic outcomes after traumatic brain injury. (20555409)
2010
9
Subtle BBB alterations in brain edema associated with acute liver failure. (20201130)
2010
10
Estrogen reduces iron-mediated brain edema and neuronal death. (19812941)
2010
11
The protein kinase C activator phorbol myristate acetate decreases brain edema by aquaporin 4 downregulation after middle cerebral artery occlusion in the rat. (19831719)
2010
12
Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure. (20217200)
2010
13
Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia. (20029450)
2010
14
The effects of protein kinase C activator phorbol dibutyrate on traumatic brain edema and aquaporin-4 expression. (21038114)
2010
15
Diffuse leukoencephalopathy and brain edema: unusual presentations of CNS relapse of acute myeloid leukemia. (18826442)
2010
16
Minocycline attenuates brain edema, brain atrophy and neurological deficits after intracerebral hemorrhage. (19812938)
2010
17
Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline. (19220703)
2009
18
Correlation of macrophage inflammatory protein-2 expression and brain edema in rats after intracerebral hemorrhage. (18830379)
2009
19
Corticorelin acetate injections for the treatment of peritumoral brain edema. (19678803)
2009
20
Brain edema after carotid revascularization: benign syndrome or prelude to hemorrhage? (24207156)
2009
21
Bifrontal decompressive craniectomy is a life-saving procedure for patients with nontraumatic refractory brain edema. (19234910)
2009
22
Inhibition of bradykinin B2 receptors before, not after onset of experimental subarachnoid hemorrhage prevents brain edema formation and improves functional outcome. (19487935)
2009
23
Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage. (18096835)
2008
24
LPS-induced endotoxic shock does not cause early brain edema formation - an MRI study in rats. (18830562)
2008
25
Plasmatic B-type natriuretic peptide and C-reactive protein in hyperacute stroke as markers of CT-evidence of brain edema. (18219371)
2008
26
Aquaporins: role in cerebral edema and brain water balance. (17618977)
2007
27
Experimental ischemic brain edema: morphological and magnetic resonance imaging findings. (17613229)
2007
28
Brain edema after intracerebral hemorrhage: mechanisms, treatment options, management strategies, and operative indications. (17613237)
2007
29
Surgery for brain edema. (17613232)
2007
30
Protective effect of the V1a receptor antagonist SR49059 on brain edema formation following middle cerebral artery occlusion in the rat. (16671476)
2006
31
Brain edema and inflammatory activation in bile duct ligated rats with diet-induced hyperammonemia: A model of hepatic encephalopathy in cirrhosis. (16729306)
2006
32
Whole-body hyperthermia in the rat disrupts the blood-cerebrospinal fluid barrier and induces brain edema. (16671499)
2006
33
Zygomycosis involving lungs, heart and brain, superimposed on pulmonary edema. (15826246)
2005
34
Comparison of brain natriuretic peptide and probrain natriuretic peptide in the diagnosis of cardiogenic pulmonary edema in patients aged 65 and older. (15817011)
2005
35
Effects of magnesium sulfate on traumatic brain edema in rats. (15294111)
2004
36
Aquaporins and brain edema. (15120208)
2004
37
Long-term hypothermia in patients with severe brain edema after poor-grade subarachnoid hemorrhage: feasibility and intensive care complications. (12826972)
2003
38
Effects of magnesium administration on brain edema and blood-brain barrier breakdown after experimental traumatic brain injury in rats. (12657997)
2003
39
Brain edema after human cerebral hemorrhage: a magnetic resonance imaging volumetric analysis. (12826970)
2003
40
Brain edema in acute liver failure. (15025258)
2003
41
Neuroprotective effects of nimodipine and MK-801 on acute infectious brain edema induced by injection of pertussis bacilli to neocortex of rats. (12659709)
2003
42
Glucose-derived osmolytes and energy impairment in brain edema accompanying liver failure: the role of glutamine reevaluated. (12949742)
2003
43
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects. (12602520)
2002
44
Effects of brain hypothermia on brain edema formation after intracerebral hemorrhage in rats. (12168313)
2002
45
Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist. (11596963)
2001
46
Dissociation of brain edema induced by cold injury in rat model: MR imaging and perfusion studies with 14C-iodo-antipyrine. (11577758)
2001
47
Enoxaparin reduces brain edema, cerebral lesions, and improves motor and cognitive impairments induced by a traumatic brain injury in rats. (11101208)
2000
48
Protective effect of a novel vitamin E derivative on experimental traumatic brain edema in rats--preliminary study. (11450040)
2000
49
Cold injury in mice: a model to study mechanisms of brain edema and neuronal apoptosis. (10096842)
1999
50
Effect of catalase on regional cerebral blood flow and brain edema during the early phase of experimental pneumococcal meningitis. (1431262)
1992

Genetic Variations for Brain Edema

About this section

Expression for genes affiliated with Brain Edema

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Brain Edema

Search GEO for disease gene expression data for Brain Edema.

Pathways for genes affiliated with Brain Edema

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Brain Edema

About this section
Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 49PharmGKB
See all sources

Compounds related to Brain Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1mannitol44 1111.8AQP4
2cereport4410.7BDKRB2, KNG1
3fr17365744 2811.7BDKRB2, KNG1
4fr19099744 2811.7BDKRB2, KNG1
5lys-[des-arg9]bradykinin5910.7BDKRB2, KNG1
6win 64338 hydrochloride5910.6BDKRB2, KNG1
7n(g)-nitro-l-arginine methyl ester4410.6BDKRB2, SOD1, KNG1
8ng-nitro-l-arginine4410.6BDKRB2, SOD1, KNG1
9r 7155910.6BDKRB2, KNG1
10hoe 1405910.6BDKRB2, KNG1
11mercury4410.6MIP, AQP1, AQP4
12quinaprilat4410.6BDKRB2, KNG1
13hg2+4410.6MIP, AQP1
14candesartan44 28 1112.6AGER, KNG1, BDKRB2
15ramiprilat4410.6KNG1, BDKRB2
16citrulline44 2411.6SOD1, KNG1, SLC25A13, OTC
17des-arg(10)-kallidin4410.6KNG1, BDKRB2
18ammonium4410.6MIP, GLUL, OTC, AQP1
19silver4410.5AQP1, GFAP, GLUL, MIP
202-mercaptoethanol4410.5ANXA1, GFAP, AQP1
21sodium nitroprusside4410.5BDKRB2, SOD1, KNG1, AQP1
22icatibant44 28 1112.5KNG1, BDKRB2
23(s)-ketoprofen4410.5OXA1L, KNG1
24chloride4410.5MIP, GLUL, TSPO, AQP1, AQP4
25urea44 11 2412.4MIP, GLUL, SLC25A13, OTC, AQP1, AQP4
26gaba4410.4BDKRB2, GLUL, GFAP, TSC22D3, TSPO
27lactate4410.3SOD1, ANXA1, MIP, GLUL, GFAP, OTC
28tetraethylammonium44 28 1112.3KNG1, MIP, AQP1
29potassium44 11 2412.3KNG1, MIP, GFAP, AQP1, AQP4
30oxygen44 2411.3SLC7A11, GFAP, GLUL, MIP, ANXA1
31l-nmma4410.3KNG1, SOD1, BDKRB2
32glycerol44 11 2412.3MIP, GLUL, SLC25A13, OTC, TSPO, AQP1
33n(epsilon)-(carboxymethyl)lysine4410.3AGER, OXA1L
34h2o24410.2SOD1, ANXA1, OXA1L, MIP, GLUL, TSPO
35atp44 2811.2BDKRB2, KNG1, ANXA1, MIP, GLUL, GFAP
36creatinine4410.2BDKRB2, SOD1, AGER, GLUL, GFAP, OTC
37dexamethasone44 49 28 1113.1BDKRB2, ANXA1, MIP, GLUL, GFAP, TSC22D3
38serine4410.1BDKRB2, KNG1, AGER, ANXA1, GLUL, GFAP
39nitric oxide44 11 2412.1BDKRB2, SOD1, KNG1, AGER, ANXA1, MIP
40glucose4410.1AGER, MIP, GLUL, GFAP, SLC5A7, OTC
41oligonucleotide4410.1AGER, ANXA1, CLDN5, OTC, AQP1, AQP4
42cysteine4410.1BDKRB2, SOD1, OXA1L, MIP, GLUL, GFAP
43arginine4410.0BDKRB2, SOD1, KNG1, MIP, GLUL, GFAP
44glutamate4410.0BDKRB2, SOD1, MIP, GLUL, GFAP, SLC25A13
45nacl4410.0AQP1, GLUL, MIP, ANXA1
46sodium44 2411.0AQP4, BDKRB2, KNG1, MIP, GLUL, SLC5A7
47lipid4410.0BDKRB2, SOD1, AGER, ANXA1, MIP, GLUL
48threonine449.9OTC, SLC25A13, GFAP, GLUL, ANXA1, BDKRB2
49sucrose44 11 2411.8ANXA1, GLUL, AQP1, AQP4
50calcium44 49 11 2412.7ANXA1, AGER, PROC, KNG1, BDKRB2, MIP

GO Terms for genes affiliated with Brain Edema

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Brain Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.9SOD1, ANXA1, OXA1L, GLUL, AQP4
2integral to plasma membraneGO:0058879.8BDKRB2, AGER, MIP, SLC25A13, AQP1, AQP4
3basolateral plasma membraneGO:0163239.8AQP4, AQP1, ANXA1, KCNJ10
4plasma membraneGO:0058869.2AQP4, KCNJ10, BDKRB2, SOD1, KNG1, PROC

Biological processes related to Brain Edema according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal water homeostasisGO:05089110.4AQP1, AQP4
2carbon dioxide transportGO:01567010.3AQP4, AQP1
3water transportGO:00683310.3AQP4, AQP1, MIP
4arachidonic acid secretionGO:05048210.3ANXA1, BDKRB2
5response to drugGO:04249310.2SOD1, ANXA1, OTC, TSPO, AQP1
6inflammatory responseGO:00695410.1ANXA1, AGER, KNG1, BDKRB2, KCNJ10
7transmembrane transportGO:05508510.1AQP4, AQP1, TSC22D3, SLC7A11, SLC5A7, MIP
8negative regulation of blood coagulationGO:03019510.0PROC, KNG1
9negative regulation of apoptotic processGO:0430669.9BDKRB2, PROC, ANXA1, TSC22D3, AQP1

Molecular functions related to Brain Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1water channel activityGO:01525010.3AQP1, MIP
2water transmembrane transporter activityGO:00537210.0AQP4, AQP1

Products for genes affiliated with Brain Edema

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brain Edema

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet