MCID: BRN004
MIFTS: 55

Brain Edema malady

Neuronal category

Summaries for Brain Edema

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Cerebral edema or cerebral œdema is an excess accumulation of fluid in the intracellular or... more...

MalaCards: Brain Edema, also known as intracranial swelling, is related to acute liver failure and stroke, ischemic. An important gene associated with Brain Edema is AQP4 (aquaporin 4), and among its related pathways are Passive Transport by Aquaporins and Complement and coagulation cascades. The drugs dexamethasone and dexamethasone acetate and the compounds mannitol and cereport have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Aliases & Classifications for Brain Edema

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

brain edema 8 10 45 61
intracranial swelling 8
wet brain 8


External Ids:

Disease Ontology8 DOID:4724
SNOMED-CT57 2032001, 85974009
MeSH35 D001929

Related Diseases for Brain Edema

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Brain Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1acute liver failure31.0TSPO, OTC
2stroke, ischemic30.4AQP4, TSPO
3brain disease30.4SLC25A13, OTC, TSPO, AQP4
4uremia29.9SOD1, AGER, OXA1L
5brain cancer29.9AQP4, TSPO, GFAP, MIP, BDKRB2
6astrocytoma29.9BDKRB2, KNG1, GLUL, GFAP, TSPO, AQP1
7brain injury10.9
8traumatic brain injury10.7
9hemorrhage, intracerebral10.7
10brain ischemia10.7
11brain meningioma10.7
12cerebral artery occlusion10.5
13brain glioma10.4
14hypoxia10.4
15pneumococcal meningitis10.3
16diabetic ketoacidosis10.2
17middle cerebral artery infarction10.2
18arteriovenous malformation10.2
19benign meningioma10.2
20head injury10.2
21cerebral malaria10.1
22transient cerebral ischemia10.1
23idiopathic edema10.1
24venous thrombosis10.1
25stroke, hemorrhagic10.1
26wernicke-korsakoff syndrome10.1
27hepatitis10.0OTC
28migraine10.0OXA1L
29peritonitis10.0AQP1
30maple syrup urine disease10.0OTC
31menieres disease10.0MIP
32pancreatitis10.0KNG1, SOD1
33lung cancer10.0SLC5A7
34eye disease10.0TSPO
35acute pancreatitis10.0SOD1
36myeloma10.0GLUL, OXA1L
37hypertension10.0KNG1
38hypercholesterolemia10.0KNG1
39diabetic retinopathy10.0AGER, SOD1
40encephalomyelitis10.0AQP4
41myopathy10.0ANXA1, GLUL
42cholera10.0OXA1L, KNG1
43influenza10.0KNG1, OXA1L
44pneumonia10.0MIP, OXA1L, KNG1
45hereditary angioedema10.0KNG1, BDKRB2
46anaplastic astrocytoma10.0GFAP
47fibromyalgia10.0TSPO
48disseminated intravascular coagulation10.0PROC
49glaucoma10.0MIP, AQP1, AQP4
50multiple sclerosis10.0GFAP, TSPO, AQP4

Graphical network of the top 20 diseases related to Brain Edema:



Diseases related to brain edema

Clinical Features for Brain Edema

Drugs & Therapeutics for Brain Edema

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Brain Edema

Drug clinical trials:

Search ClinicalTrials for Brain Edema

Search NIH Clinical Center for Brain Edema

Search CenterWatch for Brain Edema

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Brain Edema

Anatomical Context for Brain Edema

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Brain Edema:

33
Liver, Brain, Lung, Whole blood, Heart, Prostate, Myeloid, B cells, Endothelial

Animal Models for Brain Edema or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Brain Edema

Sources:
51PubMed
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Articles related to Brain Edema:

(show top 50)    (show all 574)
idTitleAuthorsYear
1
The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury. (24346689)
2013
2
Skull base secretory meningioma. Value of histological and immunohistochemical findings for peritumoral brain edema formation. (23645307)
2013
3
Foxo3a transcriptionally upregulates AQP4 and induces cerebral edema following traumatic brain injury. (24174672)
2013
4
Cerebral hemorrhage, brain edema, and heme oxygenase-1 expression after experimental traumatic brain injury. (23564109)
2013
5
The effects of lornoxicam on brain edema and blood brain barrier following diffuse traumatic brain injury in rats. (23884669)
2013
6
Increased toll-like receptor 4 in cerebral endothelial cells contributes to the astrocyte swelling and brain edema in acute hepatic encephalopathy. (24261962)
2013
7
Roles of Changes in Active Glutamine Transport in Brain Edema Development During Hepatic Encephalopathy: An Emerging Concept. (24072671)
2013
8
Expression of astrocytic genes coding for proteins implicated in neural excitation and brain edema is altered after acute liver failure. (24164438)
2013
9
Brain edema and encephalopathy in acute liver failure: a primary neurogliopathy? (22381564)
2012
10
Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy. (22609932)
2012
11
Ethanol-induced hyponatremia augments brain edema after traumatic brain injury. (22746038)
2012
12
Diagnostic utility of C-reactive protein combined with brain natriuretic peptide in acute pulmonary edema: a cross sectional study. (21696613)
2011
13
Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia. (22174658)
2011
14
Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. (21658430)
2011
15
Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. (21904632)
2011
16
Expression of aquaporin-4 in human supratentorial meningiomas with peritumoral brain edema and correlation of VEGF with edema formation. (21968684)
2011
17
Calcitonin gene-related peptide prevents blood-brain barrier injury and brain edema induced by focal cerebral ischemia reperfusion. (21718723)
2011
18
The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats. (20570121)
2010
19
Nicotine exacerbates brain edema during in vitro and in vivo focal ischemic conditions. (19889792)
2010
20
The effects of selective brain hypothermia and decompressive craniectomy on brain edema after closed head injury in mice. (19812954)
2010
21
Liposome-encapsulated hemoglobin alleviates brain edema after permanent occlusion of the middle cerebral artery in rats. (19178460)
2009
22
Blood-brain barrier damage and brain penetration of antiepileptic drugs: role of serum proteins and brain edema. (19175391)
2009
23
Decompressive surgery for severe brain edema. (19321537)
2009
24
AQP4 expression in the brains of patients with glioblastoma and its association with brain edema]. (19764565)
2009
25
Tissue-type transglutaminase and the effects of cystamine on intracerebral hemorrhage-induced brain edema and neurological deficits. (19007756)
2009
26
Peritumoral brain edema in meningiomas: correlations between magnetic resonance imaging, angiography, and pathology. (18262249)
2008
27
Alleviation of ischemia-induced brain edema by activation of the central histaminergic system in rats. (18787305)
2008
28
Brain edema in acute liver failure: can it be prevented? Can it be treated? (17316881)
2007
29
A review of progress in understanding the pathophysiology and treatment of brain edema. (17613227)
2007
30
Midline-shift corresponds to the amount of brain edema early after hemispheric stroke--an MRI study in rats. (17413996)
2007
31
Effect of VEGF receptor antagonist (VGA1155) on brain edema in the rat cold injury model. (18204296)
2007
32
Inflammation and brain edema: new insights into the role of chemokines and their receptors. (16671502)
2006
33
A new method for the early diagnosis of brain edema/brain swelling. An experimental study in rabbits. (16413930)
2006
34
Occludin expression in brain tumors and its relevance to peritumoral edema and survival. (19771274)
2006
35
Brain edema and aquaporin]. (16313100)
2005
36
Release of bradykinin and expression of kinin B2 receptors in the brain: role for cell death and brain edema formation after focal cerebral ischemia in mice. (15815587)
2005
37
Free radicals as triggers of brain edema formation after stroke. (15925278)
2005
38
Hyperammonemia, brain edema and blood-brain barrier alterations in prehepatic portal hypertensive rats and paracetamol intoxication. (15112350)
2004
39
Noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging. (14739415)
2004
40
Brain edema -- a new classification. (12781651)
2003
41
Treatment of cold injury-induced brain edema with a nonspecific matrix metalloproteinase inhibitor MMI270 in rats. (12908926)
2003
42
Overexpression of interleukin-1 receptor antagonist reduces brain edema induced by intracerebral hemorrhage and thrombin. (14753487)
2003
43
Hypertensive intracerebral hemorrhage and brain edema. (12201562)
2002
44
Effects of centrally administered arginine vasopressin and atrial natriuretic peptide on the development of brain edema in hyponatremic rats. (11523682)
2001
45
Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats. (11546909)
2001
46
Inhibition of cyclooxygenase 2 by nimesulide decreases prostaglandin E2 formation but does not alter brain edema or clinical recovery after closed head injury in rats. (10636620)
2000
47
Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. (10733542)
2000
48
Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis. (10498637)
1999
49
Cytoxicity of [(5,6-dichloro-9a-n-propyl-2,3,9,9a-tetrahydro-3-oxo-1H fluoren-7-yl)oxy]acetic acid, an agent known to reduce brain edema. (8672727)
1996
50
Is it solely aquaporins? The mechanisms of brain edemaa88a8 (21704906)
.

Genetic Variations for Brain Edema

Expression for genes affiliated with Brain Edema

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Brain Edema

Search GEO for disease gene expression data for Brain Edema.

Pathways for genes affiliated with Brain Edema

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Brain Edema

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 50PharmGKB
See all sources

Compounds related to Brain Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1mannitol45 1111.8AQP4
2cereport4510.7BDKRB2, KNG1
3fr17365745 2911.7BDKRB2, KNG1
4fr19099745 2911.7BDKRB2, KNG1
5lys-[des-arg9]bradykinin6010.7BDKRB2, KNG1
6win 64338 hydrochloride6010.6BDKRB2, KNG1
7n(g)-nitro-l-arginine methyl ester4510.6BDKRB2, SOD1, KNG1
8ng-nitro-l-arginine4510.6BDKRB2, SOD1, KNG1
9r 7156010.6BDKRB2, KNG1
10hoe 1406010.6BDKRB2, KNG1
11mercury4510.6MIP, AQP1, AQP4
12quinaprilat4510.6BDKRB2, KNG1
13hg2+4510.6MIP, AQP1
14candesartan45 29 1112.6AGER, KNG1, BDKRB2
15ramiprilat4510.6KNG1, BDKRB2
16citrulline45 2411.6SOD1, KNG1, SLC25A13, OTC
17des-arg(10)-kallidin4510.6KNG1, BDKRB2
18ammonium4510.6MIP, GLUL, OTC, AQP1
19silver4510.5AQP1, GFAP, GLUL, MIP
202-mercaptoethanol4510.5ANXA1, GFAP, AQP1
21sodium nitroprusside4510.5BDKRB2, SOD1, KNG1, AQP1
22icatibant45 29 1112.5KNG1, BDKRB2
23(s)-ketoprofen4510.5OXA1L, KNG1
24chloride4510.5MIP, GLUL, TSPO, AQP1, AQP4
25urea45 11 2412.4MIP, GLUL, SLC25A13, OTC, AQP1, AQP4
26gaba4510.4BDKRB2, GLUL, GFAP, TSC22D3, TSPO
27lactate4510.3SOD1, ANXA1, MIP, GLUL, GFAP, OTC
28tetraethylammonium45 29 1112.3KNG1, MIP, AQP1
29potassium45 11 2412.3KNG1, MIP, GFAP, AQP1, AQP4
30oxygen45 2411.3SLC7A11, GFAP, GLUL, MIP, ANXA1
31l-nmma4510.3KNG1, SOD1, BDKRB2
32glycerol45 11 2412.3MIP, GLUL, SLC25A13, OTC, TSPO, AQP1
33n(epsilon)-(carboxymethyl)lysine4510.3AGER, OXA1L
34h2o24510.2SOD1, ANXA1, OXA1L, MIP, GLUL, TSPO
35atp45 2911.2BDKRB2, KNG1, ANXA1, MIP, GLUL, GFAP
36creatinine4510.2BDKRB2, SOD1, AGER, GLUL, GFAP, OTC
37dexamethasone45 50 29 1113.1BDKRB2, ANXA1, MIP, GLUL, GFAP, TSC22D3
38serine4510.1BDKRB2, KNG1, AGER, ANXA1, GLUL, GFAP
39nitric oxide45 11 2412.1BDKRB2, SOD1, KNG1, AGER, ANXA1, MIP
40glucose4510.1AGER, MIP, GLUL, GFAP, SLC5A7, OTC
41oligonucleotide4510.1AGER, ANXA1, CLDN5, OTC, AQP1, AQP4
42cysteine4510.1BDKRB2, SOD1, OXA1L, MIP, GLUL, GFAP
43arginine4510.0BDKRB2, SOD1, KNG1, MIP, GLUL, GFAP
44glutamate4510.0BDKRB2, SOD1, MIP, GLUL, GFAP, SLC25A13
45nacl4510.0AQP1, GLUL, MIP, ANXA1
46sodium45 2411.0AQP4, BDKRB2, KNG1, MIP, GLUL, SLC5A7
47lipid4510.0BDKRB2, SOD1, AGER, ANXA1, MIP, GLUL
48threonine459.9OTC, SLC25A13, GFAP, GLUL, ANXA1, BDKRB2
49sucrose45 11 2411.8ANXA1, GLUL, AQP1, AQP4
50calcium45 50 11 2412.7ANXA1, AGER, PROC, KNG1, BDKRB2, MIP

GO Terms for genes affiliated with Brain Edema

Sources:
16Gene Ontology
See all sources

Cellular components related to Brain Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.9SOD1, ANXA1, OXA1L, GLUL, AQP4
2integral to plasma membraneGO:0058879.8BDKRB2, AGER, MIP, SLC25A13, AQP1, AQP4
3basolateral plasma membraneGO:0163239.8AQP4, AQP1, ANXA1, KCNJ10
4plasma membraneGO:0058869.2AQP4, KCNJ10, BDKRB2, SOD1, KNG1, PROC

Biological processes related to Brain Edema according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal water homeostasisGO:05089110.4AQP1, AQP4
2carbon dioxide transportGO:01567010.3AQP4, AQP1
3water transportGO:00683310.3AQP4, AQP1, MIP
4arachidonic acid secretionGO:05048210.3ANXA1, BDKRB2
5response to drugGO:04249310.2SOD1, ANXA1, OTC, TSPO, AQP1
6inflammatory responseGO:00695410.1ANXA1, AGER, KNG1, BDKRB2, KCNJ10
7transmembrane transportGO:05508510.1AQP4, AQP1, TSC22D3, SLC7A11, SLC5A7, MIP
8negative regulation of blood coagulationGO:03019510.0PROC, KNG1
9negative regulation of apoptotic processGO:0430669.9BDKRB2, PROC, ANXA1, TSC22D3, AQP1

Molecular functions related to Brain Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1water channel activityGO:01525010.3AQP1, MIP
2water transmembrane transporter activityGO:00537210.0AQP4, AQP1

Products for genes affiliated with Brain Edema

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  • Proteins
  • Lysates
  • Antibodies

Sources for Brain Edema

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet