MCID: BRN004
MIFTS: 55

Brain Edema malady

Neuronal diseases category
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Summaries for Brain Edema

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Wikipedia:65 Cerebral edema or cerebral oedema is excess accumulation of fluid in the intracellular or extracellular... more...

MalaCards based summary: Brain Edema, also known as intracranial swelling, is related to hepatic encephalopathy and ischemia. An important gene associated with Brain Edema is AQP4 (aquaporin 4), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Regulation of Water Balance by Renal Aquaporins. The drugs dexamethasone and mannitol and the compounds cereport and fr173657 have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and endothelial, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Aliases & Classifications for Brain Edema

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Brain Edema, Aliases & Descriptions:

Name: Brain Edema 8 10 44 62
Intracranial Swelling 8 62
 
Wet Brain 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:4724
SNOMED-CT57 2032001, 85974009
MeSH34 D001929

Related Diseases for Brain Edema

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Diseases related to Brain Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1hepatic encephalopathy30.8GLUL, AQP4
2ischemia30.0SOD1, AQP4, MIP, KNG1, GLUL, BDKRB2
3glioblastoma29.7AQP4, MIP, KNG1, GLUL
4cerebrovascular disease29.6AQP4, MIP, BDKRB2, OTC
5astrocytoma29.5BDKRB2, GLUL, KNG1, AQP4
6cerebritis10.9
7brain injury10.9
8traumatic brain injury10.8
9meningioma10.7
10acute liver failure10.7
11hepatitis10.6
12neuronitis10.6
13endotheliitis10.6
14cerebral artery occlusion10.5
15nephrogenic diabetes insipidus10.5AQP4
16meningitis10.4
17diabetic cataract10.4MIP
18hypertension10.4
19meniere's disease10.4MIP
20hypoxia10.4
21pneumococcal meningitis10.3
22diabetic ketoacidosis10.3
23intracranial hypertension10.3
24cerebral hemorrhage10.2
25malaria10.2
26middle cerebral artery infarction10.2
27cerebral malaria10.2
28benign meningioma10.2
29arteriovenous malformation10.2
30head injury10.2
31senile cataract10.2MIP, SOD1
32stroke, ischemic10.2KNG1, AQP4
33hereditary angioedema10.2BDKRB2, KNG1
34hyperhomocysteinemia10.2SOD1, KNG1
35wilson disease10.2OTC, SOD1
36chronic granulomatous disease10.2SOD1, OTC
37angioedema10.1KNG1, BDKRB2
38brain disease10.1OTC, AQP4
39burns10.1
40liver disease10.1
41non-suppurative otitis media10.1KNG1, BDKRB2
42congestive heart failure10.1KNG1, MIP
43pancreatitis10.1KNG1, SOD1
44coronary artery anomaly10.1KNG1, SOD1
45wernicke-korsakoff syndrome10.1
46acute intermittent porphyria10.1SOD1, GLUL
47temporal lobe epilepsy10.0GLUL, AQP4
48reye syndrome10.0GLUL, OTC
49duchenne muscular dystrophy10.0OTC, MIP, AQP4
50vascular disease10.0OTC, KNG1, SOD1

Graphical network of the top 20 diseases related to Brain Edema:



Diseases related to brain edema

Symptoms for Brain Edema

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Drugs & Therapeutics for Brain Edema

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Genetic Tests for Brain Edema

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Anatomical Context for Brain Edema

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MalaCards organs/tissues related to Brain Edema:

32
Brain, Liver, Endothelial, Lung, Breast, Prostate, Myeloid

Animal Models for Brain Edema or affiliated genes

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MGI Mouse Phenotypes related to Brain Edema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2SOD1, AQP4, BDKRB2, OTC
2MP:00107687.7OTC, BDKRB2, GLUL, AQP4, SOD1
3MP:00053867.6SOD1, AQP4, GLUL, BDKRB2, OTC
4MP:00053767.3OTC, BDKRB2, GLUL, KNG1, AQP4, SOD1

Publications for Brain Edema

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Articles related to Brain Edema:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Brain edema and protein expression of c-Fos and c-Jun in the brain after diffused brain injury. (25031700)
2014
2
Brain Edema Predicts Outcome After Nonlacunar Ischemic Stroke. (25336512)
2014
3
Alleviation of brain edema and restoration of functional independence by bevacizumab in brain-metastatic breast cancer: a case report. (24944558)
2014
4
Interactions of connexin 43 and aquaporin-4 in the formation of glioma-induced brain edema. (25373717)
2014
5
Reduction of brain edema and expression of aquaporins with acute ethanol treatment after traumatic brain injury. (23198799)
2013
6
Volumetric electromagnetic phase-shift spectroscopy of brain edema and hematoma. (23691001)
2013
7
The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury. (24346689)
2013
8
Arginine vasopressin V1a receptor-deficient mice have reduced brain edema and secondary brain damage following traumatic brain injury. (23441636)
2013
9
Baicalin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage. (23974988)
2013
10
Extent of peritumoral brain edema correlates with prognosis, tumoral growth pattern, HIF1a expression and angiogenic activity in patients with single brain metastases. (23076770)
2013
11
Modern approach in therapy of brain edema in cerebral ischemia. (22926391)
2012
12
Minimally invasive procedures for evacuation of intracerebral hemorrhage reduces perihematomal glutamate content, blood-brain barrier permeability and brain edema in rabbits. (21161434)
2011
13
Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivative. (21552121)
2011
14
The influence of benzamil hydrochloride on the evolution of hyponatremic brain edema as assessed by in vivo MRI study in rats. (21445679)
2011
15
Pentoxifylline attenuates TNF-I+ protein levels and brain edema following temporary focal cerebral ischemia in rats. (21219888)
2011
16
The role of hypoxia-inducible factor-1I+, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury. (20617879)
2011
17
Diabetes aggravates nanoparticles induced breakdown of the blood-brain barrier permeability, brain edema formation, alterations in cerebral blood flow and neuronal injury. An experimental study using physiological and morphological investigations in the rat. (21121280)
2010
18
Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage. (20132873)
2010
19
Dietary virgin olive oil reduces blood brain barrier permeability, brain edema, and brain injury in rats subjected to ischemia-reperfusion. (20602077)
2010
20
Radiation exposure prior to ischemia decreases lesion volume, brain edema and cell death. (19812920)
2010
21
Brain expression of the water channels aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema. (20938728)
2010
22
Subtle BBB alterations in brain edema associated with acute liver failure. (20201130)
2010
23
Delayed enlargement of brain edema after resection of intracranial meningioma: two case reports. (19855147)
2009
24
Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline. (19220703)
2009
25
Hypothermia attenuates oxidative/nitrosative stress, encephalopathy and brain edema in acute (ischemic) liver failure. (19428816)
2009
26
Prior ethanol injection promotes brain edema after traumatic brain injury. (19558208)
2009
27
Liposome-encapsulated hemoglobin alleviates brain edema after permanent occlusion of the middle cerebral artery in rats. (19178460)
2009
28
Serum S100B, brain edema, and hematoma formation in a rat model of collagenase-induced hemorrhagic stroke. (19027832)
2009
29
Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury. (19436311)
2009
30
MR imaging-based evidence of vasogenic brain edema in a case of acute acetone intoxication. (18202235)
2008
31
Brain edema in acute liver failure: can it be prevented? Can it be treated? (17316881)
2007
32
A review of progress in understanding the pathophysiology and treatment of brain edema. (17613227)
2007
33
Matrix metalloproteinase inhibition attenuates brain edema in an in vivo model of surgically-induced brain injury. (18091283)
2007
34
Midline-shift corresponds to the amount of brain edema early after hemispheric stroke--an MRI study in rats. (17413996)
2007
35
Protective effect of the V1a receptor antagonist SR49059 on brain edema formation following middle cerebral artery occlusion in the rat. (16671476)
2006
36
The pathophysiology of brain edema in acute liver failure. (15961187)
2005
37
Effects of magnesium sulfate on traumatic brain edema in rats. (15294111)
2004
38
The relationship between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in intracranial meningiomas. (15662977)
2004
39
Hyperammonemia, brain edema and blood-brain barrier alterations in prehepatic portal hypertensive rats and paracetamol intoxication. (15112350)
2004
40
Brain edema -- a new classification. (12781651)
2003
41
Therapeutical efficacy of a novel non-peptide bradykinin B2 receptor antagonist on brain edema formation and ischemic tissue damage in focal cerebral ischemia. (14753436)
2003
42
Antioxidant compounds EGB-761 and BN-52021 attenuate brain edema formation and hemeoxygenase expression following hyperthermic brain injury in the rat. (14753460)
2003
43
Long-term hypothermia in patients with severe brain edema after poor-grade subarachnoid hemorrhage: feasibility and intensive care complications. (12826972)
2003
44
Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. (15344903)
2003
45
Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist. (11596963)
2001
46
The effect of treatment with albumin, hetastarch, or hypertonic saline on neurological status and brain edema in a rat model of closed head trauma combined with uncontrolled hemorrhage and concurrent resuscitation in rats. (11226099)
2001
47
ONTARIO. Congenital brain edema in 2 Hereford calves. (17424613)
2000
48
Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. (10701532)
2000
49
The synergistic effect of acute subdural hematoma combined with diffuse traumatic brain injury on brain edema. (11450010)
2000
50
Role of hydrodynamic processes in the pathogenesis of peritumoral brain edema in meningiomas. (11014537)
2000

Variations for Brain Edema

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Expression for genes affiliated with Brain Edema

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Expression patterns in normal tissues for genes affiliated with Brain Edema

Search GEO for disease gene expression data for Brain Edema.

Pathways for genes affiliated with Brain Edema

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Pathways related to Brain Edema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6KNG1, SOD1
2
Show member pathways
9.6MIP, AQP4
3
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.4KNG1, BDKRB2
4
Show member pathways
9.4BDKRB2, KNG1
5
Show member pathways
citrulline-nitric oxide cycle37
arginine degradation I (arginase pathway)37
proline degradation37
glutamine degradation I37
proline biosynthesis I37
superpathway of citrulline metabolism37
proline biosynthesis II (from arginine)37
citrulline biosynthesis37
arginine degradation VI (arginase 2 pathway)37
Urea cycle and metabolism of amino groups37
asparagine biosynthesis I37
4-hydroxyproline degradation I37
citrulline degradation37
9.1OTC, GLUL

Compounds for genes affiliated with Brain Edema

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Compounds related to Brain Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1cereport449.9KNG1, BDKRB2
2fr17365744 2810.9KNG1, BDKRB2
3fr19099744 2810.9KNG1, BDKRB2
4lys-[des-arg9]bradykinin619.9KNG1, BDKRB2
5win 64338 hydrochloride619.9KNG1, BDKRB2
6benzoate449.9SOD1, OTC
7r 715619.9KNG1, BDKRB2
8hoe 140619.8KNG1, BDKRB2
9quinaprilat449.8KNG1, BDKRB2
10mercury449.8AQP4, MIP
11ramiprilat449.8KNG1, BDKRB2
12des-arg(10)-kallidin449.8KNG1, BDKRB2
13icatibant44 28 1111.8BDKRB2, KNG1
14kallidin44 2810.8KNG1, BDKRB2
15bradykinin61 28 2411.8KNG1, BDKRB2
16enalaprilat449.8BDKRB2, KNG1
17mepyramine44 1110.7KNG1, BDKRB2
18lisinopril44 50 24 1112.7BDKRB2, KNG1
19nitroglycerin44 1110.7KNG1, SOD1
20allopurinol44 50 1111.7OTC, SOD1
21candesartan44 50 28 1112.6BDKRB2, KNG1
22citrulline44 2410.5SOD1, KNG1, OTC
23mannitol44 1110.5MIP, AQP4, SOD1
24captopril44 61 50 28 1113.4BDKRB2, KNG1
25tetraethylammonium44 28 1111.4KNG1, MIP
26n(g)-nitro-l-arginine methyl ester449.4SOD1, KNG1, BDKRB2
27ng-nitro-l-arginine449.4BDKRB2, KNG1, SOD1
28l-nmma449.4SOD1, KNG1, BDKRB2
29carbamoyl phosphate449.4OTC, GLUL
30sodium nitroprusside449.3BDKRB2, KNG1, SOD1
31potassium44 24 1111.3KNG1, MIP, AQP4
32histamine44 28 2411.2AQP4, KNG1, BDKRB2
33indomethacin44 28 61 1112.2BDKRB2, KNG1, SOD1
34phosphoenolpyruvate44 1110.1OTC, GLUL
35ammonium449.0OTC, GLUL, MIP
36chloride449.0GLUL, MIP, AQP4
37malate448.8OTC, GLUL
38urea44 24 1110.7OTC, GLUL, MIP, AQP4
39glycerol44 24 1110.7AQP4, MIP, GLUL, OTC
40proline448.6MIP, GLUL, BDKRB2
41lactate448.5SOD1, MIP, GLUL, OTC
42dexamethasone44 50 28 1111.4BDKRB2, GLUL, MIP, AQP4
43creatinine448.4OTC, BDKRB2, GLUL, SOD1
44cysteine448.1BDKRB2, GLUL, MIP, AQP4, SOD1
45atp44 289.0MIP, KNG1, GLUL, BDKRB2, OTC
46lipid447.9SOD1, MIP, GLUL, BDKRB2, OTC
47sodium44 248.7OTC, BDKRB2, GLUL, KNG1, MIP, AQP4
48glutamate447.6SOD1, AQP4, MIP, GLUL, BDKRB2, OTC
49arginine447.6SOD1, MIP, KNG1, GLUL, BDKRB2, OTC
50nitric oxide44 24 119.6SOD1, MIP, KNG1, GLUL, BDKRB2, OTC

GO Terms for genes affiliated with Brain Edema

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Cellular components related to Brain Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.5GLUL, AQP4, SOD1
2plasma membraneGO:0058868.1BDKRB2, KNG1, MIP, AQP4, SOD1

Biological processes related to Brain Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vasodilationGO:0423119.5BDKRB2, KNG1
2water transportGO:0068339.5AQP4, MIP
3smooth muscle contractionGO:0069399.4BDKRB2, KNG1
4positive regulation of cytosolic calcium ion concentrationGO:0072049.4BDKRB2, KNG1
5platelet degranulationGO:0025769.3KNG1, SOD1

Products for genes affiliated with Brain Edema

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  • Antibodies
  • Proteins
  • Lysates

Sources for Brain Edema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet