MCID: BRN005
MIFTS: 26

Brain Glioblastoma Multiforme malady

Neuronal diseases category

Summaries for Brain Glioblastoma Multiforme

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32MalaCards
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MalaCards: Brain Glioblastoma Multiforme, also known as glioblastoma multiforme of brain, is related to glioblastoma multiforme and adenocarcinoma. An important gene associated with Brain Glioblastoma Multiforme is TNFSF13 (tumor necrosis factor (ligand) superfamily, member 13), and among its related pathways are TRAF Pathway and CDK-mediated phosphorylation and removal of Cdc6. The compounds pd 98,059 and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord.

Aliases & Classifications for Brain Glioblastoma Multiforme

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8Disease Ontology, 30LifeMap Discovery™, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain glioblastoma multiforme 8 30
glioblastoma multiforme of brain 8 60
brain glioblastoma 8


External Ids:

Disease Ontology8 DOID:3073
SNOMED-CT56 276828006
NCIt39 C4642

Related Diseases for Brain Glioblastoma Multiforme

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17GeneCards, 18GeneDecks
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Diseases related to Brain Glioblastoma Multiforme via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1glioblastoma multiforme30.9CASP3
2adenocarcinoma29.9HK2, CASP3
3placental choriocarcinoma10.0
4choriocarcinoma10.0
5lung adenocarcinoma10.0
6chronic lymphocytic leukemia10.0TNFSF13, CASP3
7hepatocellular carcinoma10.0HK2, CASP3

Graphical network of diseases related to Brain Glioblastoma Multiforme:



Diseases related to brain glioblastoma multiforme

Clinical Features for Brain Glioblastoma Multiforme

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Drugs & Therapeutics for Brain Glioblastoma Multiforme

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Brain Glioblastoma Multiforme

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Brain Glioblastoma Multiforme cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Glioblastoma Multiforme:
Alescat, autologous lymphocyte-based therapy for the treatment of solid cancers

Genetic Tests for Brain Glioblastoma Multiforme

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Anatomical Context for Brain Glioblastoma Multiforme

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32MalaCards
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MalaCards organs/tissues related to Brain Glioblastoma Multiforme:

32
Brain, Bone, Spinal cord, Lung, Endothelial, Pituitary

Animal Models for Brain Glioblastoma Multiforme or affiliated genes

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Publications for Brain Glioblastoma Multiforme

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50PubMed
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Articles related to Brain Glioblastoma Multiforme:

(show all 29)
idTitleAuthorsYear
1
Multiple bone metastases from glioblastoma multiforme without local brain relapse: a case report and review of the literature. (24362877)
2013
2
Treatment of brain glioblastoma multiforme with pcDNA3.1-Egr. 1p-p16 combined with gamma knife radiation: an experimental study on nude mice. (24262451)
2013
3
Search for a diagnostic/prognostic biomarker for the brain cancer glioblastoma multiforme by 2D-DIGE-MS technique. (22547198)
2012
4
Differentiation between brain glioblastoma multiforme and solitary metastasis: qualitative and quantitative analysis based on routine MR imaging. (22743640)
2012
5
Two different primary brain tumors, glioblastoma multiforme and pituitary adenoma, in association with colorectal carcinoma: an unusual case of nonfamilial Turcot's syndrome? (21735373)
2012
6
The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172. (22335784)
2012
7
Brain cancer stem cells: current status on glioblastoma multiforme. (24212782)
2011
8
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme. (21726646)
2011
9
Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells. (19784869)
2010
10
Danthron inhibits the migration and invasion of human brain glioblastoma multiforme cells through the inhibition of mRNA expression of focal adhesion kinase, Rho kinases-1 and metalloproteinase-9. (19787217)
2009
11
Aquaporin-4 contributes to the resolution of peritumoural brain oedema in human glioblastoma multiforme after combined chemotherapy and radiotherapy. (19836227)
2009
12
Spinal cord and brain glioblastoma multiforme without previous craniotomy. (18518686)
2008
13
Orphan nuclear receptor, Nurr-77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor. (18419761)
2008
14
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. (18577219)
2008
15
Organotypic distribution of stem cell markers in formalin-fixed brain harboring glioblastoma multiforme. (17516028)
2007
16
Asbestos as a possible major cause of malignant lung tumors (including small cell carcinoma, adenocarcinoma & mesothelioma), brain tumors (i.e. astrocytoma & glioblastoma multiforme), many other malignant tumors, intractable pain including fibromyalgia, & some cardio-vascular pathology: Safe & effective methods of reducing asbestos from normal & pathological areas. (17063831)
2006
17
APRIL is increased in serum of patients with brain glioblastoma multiforme. (17353162)
2006
18
Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumours. (16488082)
2006
19
Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells. (15871513)
2005
20
Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. (12734665)
2003
21
Glioblastoma multiforme of the brain stem in a patient with acquired immunodeficiency syndrome. (12376778)
2002
22
Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of tenascin and agrin. (12070669)
2002
23
Metastatic epithelioid sarcoma to the brain: palisaded necrosis mimicking glioblastoma multiforme. (12376923)
2002
24
Brain cancer: a case of glioblastoma multiforme. (12470435)
2002
25
Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue (anaplastic astrocytoma and glioblastoma multiforme). (11995970)
2001
26
Over-representation of PPARgamma sequence variants in sporadic cases of glioblastoma multiforme: preliminary evidence for common low penetrance modifiers for brain tumour risk in the general population. (10851250)
2000
27
Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue. (7535788)
1995
28
Concentration of elements in human brain: glioblastoma multiforme. (8272844)
1993
29
Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme. (1667267)
1991

Genetic Variations for Brain Glioblastoma Multiforme

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Expression for genes affiliated with Brain Glioblastoma Multiforme

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Glioblastoma Multiforme

Search GEO for disease gene expression data for Brain Glioblastoma Multiforme.

Pathways for genes affiliated with Brain Glioblastoma Multiforme

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51QIAGEN, 53Reactome, 29KEGG, 55SinoBiological, 52R&D Systems, 37NCBI BioSystems Database
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Compounds for genes affiliated with Brain Glioblastoma Multiforme

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44Novoseek
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Compounds related to Brain Glioblastoma Multiforme according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pd 98,059449.1HK2, CASP3
2rapamycin448.8HK2, CASP3

GO Terms for genes affiliated with Brain Glioblastoma Multiforme

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Products for genes affiliated with Brain Glioblastoma Multiforme

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Sources for Brain Glioblastoma Multiforme

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet