MCID: BRN005
MIFTS: 39

Brain Glioblastoma Multiforme

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Glioblastoma Multiforme

MalaCards integrated aliases for Brain Glioblastoma Multiforme:

Name: Brain Glioblastoma Multiforme 38 12 14
Glioblastoma Multiforme of Brain 12 69
Brain Glioblastoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3073
NCIt 47 C4642
SNOMED-CT 64 276828006
UMLS 69 C0349543

Summaries for Brain Glioblastoma Multiforme

MalaCards based summary : Brain Glioblastoma Multiforme, also known as glioblastoma multiforme of brain, is related to familial short qt syndrome and kleptomania, and has symptoms including headache and seizures. An important gene associated with Brain Glioblastoma Multiforme is MMP7 (Matrix Metallopeptidase 7), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Colorectal Cancer Metastasis. The drugs Temozolomide and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and bone, and related phenotypes are Decreased viability with paclitaxel and hematopoietic system

Related Diseases for Brain Glioblastoma Multiforme

Graphical network of the top 20 diseases related to Brain Glioblastoma Multiforme:



Diseases related to Brain Glioblastoma Multiforme

Symptoms & Phenotypes for Brain Glioblastoma Multiforme

UMLS symptoms related to Brain Glioblastoma Multiforme:


headache, seizures

GenomeRNAi Phenotypes related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00293-A 8.8 MRPL12 NFKBIZ TP53

MGI Mouse Phenotypes related to Brain Glioblastoma Multiforme:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 MMP7 MMP9 NFKBIZ TNFSF13 TP53 TRAP1
2 immune system MP:0005387 9.43 MMP7 MMP9 NFKBIZ TNFSF13 TP53 TRAP1
3 neoplasm MP:0002006 8.92 MMP7 MMP9 TP53 TRAP1

Drugs & Therapeutics for Brain Glioblastoma Multiforme

Drugs for Brain Glioblastoma Multiforme (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 467)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 85622-93-1 5394
2
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
3 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
4 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1
5
Carmustine Approved Phase 3,Phase 2,Phase 1 154-93-8 2578
6
Lomustine Approved Phase 3,Phase 2,Phase 1 13010-47-4 3950
7
Procarbazine Approved Phase 3,Phase 1,Phase 2 671-16-9 4915
8
Trioxsalen Approved Phase 3,Phase 2,Phase 1 3902-71-4 5585
9
Carboplatin Approved Phase 2, Phase 3, Phase 1 41575-94-4 10339178 498142 38904
10
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1 50-18-0, 6055-19-2 2907
11
Etoposide Approved Phase 2, Phase 3,Phase 1 33419-42-0 36462
12
Melphalan Approved Phase 2, Phase 3 148-82-3 4053 460612
13 Thiotepa Approved Phase 2, Phase 3,Phase 1 52-24-4 5453
14
Dacarbazine Approved, Investigational Phase 3,Phase 1,Phase 2 4342-03-4 5351166
15
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 216974-75-3
16
Aminolevulinic acid Approved Phase 3,Phase 2,Phase 1 106-60-5 137
17
Leflunomide Approved, Investigational Phase 3 75706-12-6 3899
18
Hydroxyurea Approved Phase 3,Phase 2,Phase 1 127-07-1 3657
19
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
20
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
21
Sunitinib Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 341031-54-7, 557795-19-4 5329102
22
nivolumab Approved Phase 3,Phase 1 946414-94-4
23
Dopamine Approved Phase 3,Phase 1,Phase 2 51-61-6, 62-31-7 681
24
Losartan Approved Phase 3 114798-26-4 3961
25
Meloxicam Approved, Vet_approved Phase 2, Phase 3 71125-38-7 5281106 54677470
26
Norepinephrine Approved Phase 3 51-41-2 439260
27
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
28
Vitamin C Approved, Nutraceutical Phase 3,Phase 2 50-81-7 5785 54670067
29
Cediranib Investigational Phase 3,Phase 2,Phase 1 288383-20-0 9933475
30 Dianhydrogalactitol Investigational Phase 3,Phase 1,Phase 2 23261-20-3
31
Angiotensin II Investigational Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
32 Dermatologic Agents Phase 3,Phase 2,Phase 1
33 Dihematoporphyrin Ether Phase 3,Phase 2,Phase 1
34 Ether Phase 3,Phase 2,Phase 1
35 Photosensitizing Agents Phase 3,Phase 2,Phase 1
36 Etoposide phosphate Phase 2, Phase 3,Phase 1
37 Antirheumatic Agents Phase 3,Phase 1,Phase 2
38 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
39 Protein Kinase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
40 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
41 Angiogenesis Modulating Agents Phase 3,Phase 2,Phase 1,Early Phase 1
42 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2,Phase 1
43 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
44 Central Nervous System Depressants Phase 3,Phase 2,Phase 1
45 Antibodies Phase 3,Phase 2,Phase 1
46 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
47 Immunoglobulins Phase 3,Phase 2,Phase 1
48 Vaccines Phase 3,Phase 2,Phase 1
49 Pharmaceutical Solutions Phase 2, Phase 3,Phase 1,Early Phase 1
50 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 763)

id Name Status NCT ID Phase Drugs
1 Supra-early Post-Surgery Chemotherapy in the Treatment on GBM Patients Recruiting NCT02520635 Phase 4 supra-early TEMODAL® chemotherapy;standard TEMODAL® chemotherapy
2 Assessment of Optune Therapy for Patients With Newly Diagnosed Glioblastoma Using Advanced MRI Not yet recruiting NCT03297125 Phase 4
3 Post-approval Study of NovoTTF-100A in Recurrent GBM Patients Terminated NCT01756729 Phase 4
4 Surgery, Radiation Therapy, and Chemotherapy With or Without Photodynamic Therapy in Treating Patients With Newly Diagnosed or Recurrent Malignant Supratentorial Gliomas Unknown status NCT00003788 Phase 3 carmustine;lomustine;porfimer sodium;procarbazine hydrochloride
5 Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors Unknown status NCT00179803 Phase 2, Phase 3
6 SU-101 Compared With Procarbazine in Treating Patients With Glioblastoma Multiforme Completed NCT00003293 Phase 3 leflunomide;procarbazine hydrochloride
7 Enzastaurin Versus Lomustine in Glioblastoma Completed NCT00295815 Phase 3 enzastaurin;lomustine
8 Comparison of TransMID vs Standard Treatment of Cancerous Brain Tumors Completed NCT00088400 Phase 3 TransMID
9 Radiation Therapy With or Without Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Completed NCT00006353 Phase 3 temozolomide
10 Radiation Therapy With or Without Temozolomide in Treating Older Patients With Newly Diagnosed Glioblastoma Multiforme Completed NCT00482677 Phase 3 temozolomide
11 Radiation Therapy Plus Chemotherapy in Treating Patients With Supratentorial Glioblastoma Multiforme Completed NCT00002545 Phase 3 carmustine
12 S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma Completed NCT00017147 Phase 3 carmustine;O6-Benzylguanine
13 Standard Radiation Therapy, Higher-Dose Radiation Therapy, or Chemotherapy in Treating Older Patients With Glioblastoma Multiforme Completed NCT00820963 Phase 3 temozolomide
14 Radiation Therapy (RT) and Temozolomide (TMZ) in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma Completed NCT00304031 Phase 3 Concurrent temozolomide;100mg/m2 adjuvant temozolomide days 1 to 5 of 28 day cycle;75mg/m2 adjuvant temozolomide days 1-21 of 28 day cycle
15 Phase III Trial of Primary Radio- or Chemotherapy in Malignant Astrocytoma of the Elderly Completed NCT01502241 Phase 3 Temozolomide
16 Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma Completed NCT01480479 Phase 3 Rindopepimut (CDX-110) with GM-CSF;Temozolomide;KLH
17 Study of IV Edotecarin Vs Temozolomide or Carmustine (BCNU) or Lomustine (CCNU) in Patients With Glioblastoma Multiforme Completed NCT00068952 Phase 3 Edotecarin;Temozolomide;Carmustine (BCNU);Lomustine (CCNU)
18 Radiotherapy for Malignant Astrocytomas in the Elderly Completed NCT00430911 Phase 3 Radiotherapy
19 Clinical Trial to Assess the Efficacy and Safety of 'INNOCELL Immuncell-LC' With Temozolomide in Newly Diagnosed Glioblastoma of Korea Completed NCT00807027 Phase 3 Activated T lymphocyte(Immuncell-LC)
20 Cediranib in Combination With Lomustine Chemotherapy in Recurrent Glioblastoma Completed NCT00777153 Phase 3 Cediranib;Cediranib;Lomustine Chemotherapy;Placebo Cediranib
21 Efficacy and Safety Study of Lomustine/Temozolomide Combination Therapy vs. Standard Therapy for Glioblastoma Patients Completed NCT01149109 Phase 3 Temozolomide and lomustine;Temozolomide
22 The PRECISE Trial: Study of IL13-PE38QQR Compared to GLIADEL Wafer in Patients With Recurrent Glioblastoma Multiforme Completed NCT00076986 Phase 3 IL13-PE38QQR;prolifespan 20 with carmustine implant (GLIADEL® Wafer)
23 A Study of Bevacizumab (Avastin®) in Combination With Temozolomide and Radiotherapy in Participants With Newly Diagnosed Glioblastoma Completed NCT00943826 Phase 3 Bevacizumab;Temozolomide;Placebo
24 Study of Imatinib Mesylate in Combination With Hydroxyurea Versus Hydroxyurea Alone as an Oral Therapy in Patients With Temozolomide Resistant Progressive Glioblastoma Completed NCT00154375 Phase 3 Imatinib mesylate;Hydroxyurea
25 Effect of NovoTTF-100A in Recurrent Glioblastoma Multiforme (GBM) Completed NCT00379470 Phase 3
26 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
27 Effect of NovoTTF-100A Together With Temozolomide in Newly Diagnosed Glioblastoma Multiforme (GBM) Completed NCT00916409 Phase 3 Temozolomide
28 Standard Radiation Therapy With or Without Stereotactic Radiation Therapy in Treating Patients With Glioma Completed NCT00003916 Phase 3
29 Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma Completed NCT00052455 Phase 3 lomustine;procarbazine hydrochloride;temozolomide;vincristine sulfate
30 Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Methylated Gene Promoter Status Completed NCT00689221 Phase 3 Cilengitide;Temozolomide
31 High Light and Low Light Dose PDT in Glioma Completed NCT00118222 Phase 3 porfimer sodium
32 Phase III Study Comparing 2 Brain Conformational Radiotherapy in Combination With Chemotherapy in the Treatment of Glioblastoma Recruiting NCT01507506 Phase 3
33 An Investigational Immuno-therapy Study of Temozolomide Plus Radiation Therapy With Nivolumab or Placebo, for Newly Diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer) Recruiting NCT02667587 Phase 3 Nivolumab;Temozolomide
34 An Investigational Immuno-therapy Study of Nivolumab Compared to Temozolomide, Each Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer) Recruiting NCT02617589 Phase 3 Nivolumab;Temozolomide
35 VAL-083 Phase 3 Study in Temozolomide-Avastin (Bevacizumab) Recurrent GBM Recruiting NCT03149575 Phase 3 VAL-083, Dianhydrogalactitol;Physician's Choice of Salvage Therapy - temozolomide;Physician's Choice of Salvage Therapy - lomustine;Physician's Choice of Salvage Therapy - carboplatin
36 Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme Recruiting NCT02685605 Phase 3 Temozolomide
37 Impact of Surgery on the Treatment of Supratentorial Malignant Gliomas in Subjects Aged 70 and Over Recruiting NCT02892708 Phase 3
38 Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer Active, not recruiting NCT00045968 Phase 3 Dendritic cell immunotherapy
39 Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma Active, not recruiting NCT01805453 Phase 3 Losartan;Placebo
40 A Study of the Effectiveness and Safety of Nivolumab Compared to Bevacizumab and of Nivolumab With or Without Ipilimumab in Glioblastoma Patients Active, not recruiting NCT02017717 Phase 3
41 MEDICO-ECONOMIC EVALUATION OF SURGERY GUIDED BY FLUORESCENCE FOR THE OPTIMIZATION OF RESECTION OF GLIOBLASTOMAS Active, not recruiting NCT01811121 Phase 3 5-aminolévulinique acid (5-ALA);Placebo
42 Bevacizumab and Lomustine for Recurrent GBM Active, not recruiting NCT01290939 Phase 3 lomustine
43 Proteome-based Personalized Immunotherapy of Glioblastoma Enrolling by invitation NCT01759810 Phase 2, Phase 3
44 A Phase II/III Study of High-dose, Intermittent Sunitinib in Patients With Recurrent Glioblastoma Multiforme Not yet recruiting NCT03025893 Phase 2, Phase 3 Sunitinib;Lomustine
45 Phase 3 Randomized, Double-blind, Controlled Study of ICT-107 in Glioblastoma Suspended NCT02546102 Phase 3
46 The Effect of Duloxetine on Mood, Quality of Life and Cognitive Functioning in Glioblastoma Patients Terminated NCT02443194 Phase 3 duloxetine;PLACEBO
47 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
48 Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary Glioblastoma Terminated NCT00761280 Phase 3 trabedersen;temozolomide;carmustine;lomustine
49 Study of Therapy With TransMID™ Compared to Best Standard of Care in Patients With Glioblastoma Multiforme Withdrawn NCT00083447 Phase 3 TransMID™
50 C11-Sodium Acetate PET/CT Imaging Evaluation in Brain Glioma, Post Therapy Necrosis and Pseudo-progression Withdrawn NCT01961934 Phase 2, Phase 3 Sodium Acetate C11 PET/CT Imaging

Search NIH Clinical Center for Brain Glioblastoma Multiforme

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Glioblastoma Multiforme cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Glioblastoma Multiforme:
Alescat, autologous lymphocyte-based therapy for the treatment of solid cancers

Genetic Tests for Brain Glioblastoma Multiforme

Anatomical Context for Brain Glioblastoma Multiforme

MalaCards organs/tissues related to Brain Glioblastoma Multiforme:

39
Brain, T Cells, Bone, Bone Marrow, Testes, Prostate, Spinal Cord

Publications for Brain Glioblastoma Multiforme

Articles related to Brain Glioblastoma Multiforme:

id Title Authors Year
1
Treatment of brain glioblastoma multiforme with pcDNA3.1-Egr. 1p-p16 combined with gamma knife radiation: an experimental study on nude mice. ( 24262451 )
2013
2
Differentiation between brain glioblastoma multiforme and solitary metastasis: qualitative and quantitative analysis based on routine MR imaging. ( 22743640 )
2012
3
Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells. ( 19784869 )
2010
4
Danthron inhibits the migration and invasion of human brain glioblastoma multiforme cells through the inhibition of mRNA expression of focal adhesion kinase, Rho kinases-1 and metalloproteinase-9. ( 19787217 )
2009
5
Spinal cord and brain glioblastoma multiforme without previous craniotomy. ( 18518686 )
2008
6
APRIL is increased in serum of patients with brain glioblastoma multiforme. ( 17353162 )
2006
7
Concentration of elements in human brain: glioblastoma multiforme. ( 8272844 )
1993

Variations for Brain Glioblastoma Multiforme

Expression for Brain Glioblastoma Multiforme

Search GEO for disease gene expression data for Brain Glioblastoma Multiforme.

Pathways for Brain Glioblastoma Multiforme

Pathways related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.69 MMP9 NFKBIZ TP53
2 11.55 MMP7 MMP9 TP53
3 11.3 MMP9 TP53
4 11.22 MMP7 MMP9
5
Show member pathways
11.19 MMP7 TP53
6 11.11 MMP7 MMP9
7 10.88 MMP9 TNFSF13 TP53
8 10.19 MMP7 MMP9

GO Terms for Brain Glioblastoma Multiforme

Biological processes related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 collagen catabolic process GO:0030574 8.96 MMP7 MMP9
2 positive regulation of release of cytochrome c from mitochondria GO:0090200 8.62 MMP9 TP53

Molecular functions related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 TNFSF13 TRAP1

Sources for Brain Glioblastoma Multiforme

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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