MCID: BRN005
MIFTS: 23

Brain Glioblastoma Multiforme malady

Neuronal category

Summaries for Brain Glioblastoma Multiforme

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33MalaCards
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MalaCards: Brain Glioblastoma Multiforme, also known as glioblastoma multiforme of brain, is related to adenocarcinoma and placental choriocarcinoma. An important gene associated with Brain Glioblastoma Multiforme is TNFSF13 (tumor necrosis factor (ligand) superfamily, member 13), and among its related pathways are TNF Signaling and CDK-mediated phosphorylation and removal of Cdc6. The compounds pd 98,059 and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and lung.

Aliases & Classifications for Brain Glioblastoma Multiforme

Sources:
8Disease Ontology, 31LifeMap Discovery™, 61UMLS, 40NCIt, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

brain glioblastoma multiforme 8 31
glioblastoma multiforme of brain 8 61
brain glioblastoma 8


External Ids:

Disease Ontology8 DOID:3073
SNOMED-CT57 276828006
NCIt40 C4642

Related Diseases for Brain Glioblastoma Multiforme

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17GeneCards, 18GeneDecks
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Diseases related to Brain Glioblastoma Multiforme via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.0CASP3, HK2
2placental choriocarcinoma10.0
3glioblastoma multiforme10.0CASP3
4chronic lymphocytic leukemia10.0CASP3, TNFSF13
5hepatocellular carcinoma10.0CASP3, HK2

Graphical network of diseases related to Brain Glioblastoma Multiforme:



Diseases related to brain glioblastoma multiforme

Clinical Features for Brain Glioblastoma Multiforme

Drugs & Therapeutics for Brain Glioblastoma Multiforme

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Brain Glioblastoma Multiforme

Drug clinical trials:

Search ClinicalTrials for Brain Glioblastoma Multiforme

Search NIH Clinical Center for Brain Glioblastoma Multiforme

Search CenterWatch for Brain Glioblastoma Multiforme

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Brain Glioblastoma Multiforme cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Glioblastoma Multiforme:
Alescat, autologous lymphocyte-based therapy for the treatment of solid cancers

Genetic Tests for Brain Glioblastoma Multiforme

Anatomical Context for Brain Glioblastoma Multiforme

Sources:
33MalaCards
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MalaCards organs/tissues related to Brain Glioblastoma Multiforme:

33
Brain, Spinal cord, Lung, Endothelial, Pituitary

Animal Models for Brain Glioblastoma Multiforme or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Brain Glioblastoma Multiforme

Sources:
51PubMed
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Articles related to Brain Glioblastoma Multiforme:

(show all 27)
idTitleAuthorsYear
1
Multiple bone metastases from glioblastoma multiforme without local brain relapse: a case report and review of the literature. (24362877)
2013
2
Treatment of brain glioblastoma multiforme with pcDNA3.1-Egr. 1p-p16 combined with gamma knife radiation: an experimental study on nude mice. (24262451)
2013
3
Search for a diagnostic/prognostic biomarker for the brain cancer glioblastoma multiforme by 2D-DIGE-MS technique. (22547198)
2012
4
Differentiation between brain glioblastoma multiforme and solitary metastasis: qualitative and quantitative analysis based on routine MR imaging. (22743640)
2012
5
Two different primary brain tumors, glioblastoma multiforme and pituitary adenoma, in association with colorectal carcinoma: an unusual case of nonfamilial Turcot's syndrome? (21735373)
2012
6
The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172. (22335784)
2012
7
Brain cancer stem cells: current status on glioblastoma multiforme. (24212782)
2011
8
Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme. (21726646)
2011
9
Danthron inhibits the migration and invasion of human brain glioblastoma multiforme cells through the inhibition of mRNA expression of focal adhesion kinase, Rho kinases-1 and metalloproteinase-9. (19787217)
2009
10
Aquaporin-4 contributes to the resolution of peritumoural brain oedema in human glioblastoma multiforme after combined chemotherapy and radiotherapy. (19836227)
2009
11
Spinal cord and brain glioblastoma multiforme without previous craniotomy. (18518686)
2008
12
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. (18577219)
2008
13
Organotypic distribution of stem cell markers in formalin-fixed brain harboring glioblastoma multiforme. (17516028)
2007
14
Asbestos as a possible major cause of malignant lung tumors (including small cell carcinoma, adenocarcinoma & mesothelioma), brain tumors (i.e. astrocytoma & glioblastoma multiforme), many other malignant tumors, intractable pain including fibromyalgia, & some cardio-vascular pathology: Safe & effective methods of reducing asbestos from normal & pathological areas. (17063831)
2006
15
APRIL is increased in serum of patients with brain glioblastoma multiforme. (17353162)
2006
16
Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumours. (16488082)
2006
17
Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells. (15871513)
2005
18
Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. (12734665)
2003
19
Glioblastoma multiforme of the brain stem in a patient with acquired immunodeficiency syndrome. (12376778)
2002
20
Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of tenascin and agrin. (12070669)
2002
21
Metastatic epithelioid sarcoma to the brain: palisaded necrosis mimicking glioblastoma multiforme. (12376923)
2002
22
Brain cancer: a case of glioblastoma multiforme. (12470435)
2002
23
Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue (anaplastic astrocytoma and glioblastoma multiforme). (11995970)
2001
24
Over-representation of PPARgamma sequence variants in sporadic cases of glioblastoma multiforme: preliminary evidence for common low penetrance modifiers for brain tumour risk in the general population. (10851250)
2000
25
Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue. (7535788)
1995
26
Concentration of elements in human brain: glioblastoma multiforme. (8272844)
1993
27
Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme. (1667267)
1991

Genetic Variations for Brain Glioblastoma Multiforme

Expression for genes affiliated with Brain Glioblastoma Multiforme

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Glioblastoma Multiforme

Search GEO for disease gene expression data for Brain Glioblastoma Multiforme.

Pathways for genes affiliated with Brain Glioblastoma Multiforme

Sources:
56SinoBiological, 53R&D Systems, 54Reactome, 30KEGG, 52QIAGEN, 38NCBI BioSystems Database
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Compounds for genes affiliated with Brain Glioblastoma Multiforme

Sources:
45Novoseek
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Compounds related to Brain Glioblastoma Multiforme according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pd 98,059459.1HK2, CASP3
2rapamycin458.8HK2, CASP3

GO Terms for genes affiliated with Brain Glioblastoma Multiforme

Products for genes affiliated with Brain Glioblastoma Multiforme

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  • Proteins
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Sources for Brain Glioblastoma Multiforme

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet