MCID: BRN032
MIFTS: 48

Brain Glioma malady

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Glioma

Aliases & Descriptions for Brain Glioma:

Name: Brain Glioma 12 29 14
Intracranial Glioma 69
Lower Grade Glioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060108

Summaries for Brain Glioma

Disease Ontology : 12 A brain cancer that has material basis in glial cells.

MalaCards based summary : Brain Glioma, also known as intracranial glioma, is related to glioma and brain oligodendroglioma. An important gene associated with Brain Glioma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and t cells, and related phenotypes are cardiovascular system and digestive/alimentary

Related Diseases for Brain Glioma

Diseases related to Brain Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Related Disease Score Top Affiliating Genes
1 glioma 11.3
2 brain oligodendroglioma 10.8
3 liver fibrosarcoma 10.3 GFAP TP53
4 cervical adenoid cystic carcinoma 10.3 GFAP TP53
5 ophn1 syndrome 10.3 GFAP MGMT
6 wolffian adnexal neoplasm 10.3 EGFR TP53
7 bronchitis 10.3 GFAP TP53
8 bile duct clear cell adenocarcinoma 10.3 GFAP TP53
9 hypothalamic neoplasm 10.3 GFAP NES
10 cervical benign neoplasm 10.3 GFAP TP53
11 angiofollicular lymph hyperplasia 10.3 GFAP NES
12 clear cell meningioma 10.2 GFAP TP53
13 congenital sucrase-isomaltase deficiency without sucrose intolerance 10.2 NOTCH1 TP53
14 childhood kidney cell carcinoma 10.2 GFAP NES
15 brain stem astrocytic neoplasm 10.2 GFAP MGMT TP53
16 amyloid tumor 10.2 GFAP MGMT TP53
17 porokeratosis 10.2 GFAP TP53
18 nephrogenic adenoma of urinary bladder 10.2 GFAP NES
19 breast epithelioid hemangioma 10.2 NOTCH1 TP53
20 vulvar benign neoplasm 10.2 GFAP NES TP53
21 adult brainstem gliosarcoma 10.2 GFAP NES TP53
22 adenofibroma 10.2 GFAP NES
23 liddle syndrome, scnn1g-related 10.2 EGFR NOTCH1
24 inner ear cancer 10.2 GFAP NES TP53
25 central nervous system hemangioma 10.2 GFAP NES TP53
26 endometrial squamous cell carcinoma 10.2 MGMT TP53
27 facial dermatosis 10.2 EGFR MGMT TP53
28 brainstem intraparenchymal clear cell meningioma 10.1 EGFR TP53
29 hair disease 10.1 NES TP53
30 interstitial lung disease 10.1 EGFR GFAP MGMT TP53
31 early myoclonic encephalopathy 10.1 EGFR GFAP MGMT TP53
32 gastroesophageal junction adenocarcinoma 10.1 EGFR NOTCH1 TP53
33 marginal zone b-cell lymphoma 10.1 EGFR GFAP MGMT TP53
34 adult oligodendroglioma 10.1 EGFR GFAP MGMT TP53
35 malignant pleural solitary fibrous tumor 10.1 EGFR GFAP MGMT TP53
36 paternal uniparental disomy of chromosome 1 10.1 EGFR GFAP NES TP53
37 childhood embryonal testis carcinoma 10.1 EGFR GFAP NES TP53
38 epimetaphyseal dysplasia cataract 10.0 EGFR GFAP MGMT NES
39 basal cell nevus syndrome 10.0 GFAP MGMT NES TP53
40 cutaneous adenocystic carcinoma 10.0 GFAP MGMT NOTCH1 TP53
41 middle ear disease 10.0 GFAP TP53
42 juvenile astrocytoma 10.0 EGFR GFAP MGMT NES TP53
43 nodular goiter 10.0 EGFR GFAP MGMT NES TP53
44 adult astrocytic tumour 10.0 EGFR GFAP MGMT NES TP53
45 grade iii astrocytoma 10.0 EGFR GFAP MGMT NES TP53
46 juvenile onset parkinson disease 19a 9.9 BMP2 BMP4
47 tarsal-carpal coalition syndrome 9.9 BMP2 BMP4
48 cerebritis 9.8
49 hypoxia 9.7
50 schistosomiasis 9.5

Graphical network of the top 20 diseases related to Brain Glioma:



Diseases related to Brain Glioma

Symptoms & Phenotypes for Brain Glioma

MGI Mouse Phenotypes related to Brain Glioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 BMP2 BMP4 EGFR FASLG GFAP MYBBP1A
2 digestive/alimentary MP:0005381 9.8 BMP2 BMP4 EGFR FASLG GFAP NOTCH1
3 hearing/vestibular/ear MP:0005377 9.55 EGFR NOTCH1 TP53 BMP2 BMP4
4 normal MP:0002873 9.5 BMP2 BMP4 EGFR FASLG GFAP NOTCH1
5 respiratory system MP:0005388 9.1 BMP4 EGFR FASLG MGMT NOTCH1 TP53

Drugs & Therapeutics for Brain Glioma

Drugs for Brain Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 575)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 4342-03-4 5351166
2
Temozolomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 85622-93-1 5394
3 Piracetam Approved Phase 4,Phase 2 7491-74-9
4
Valproic Acid Approved, Investigational Phase 4,Phase 2,Phase 1 99-66-1 3121
5
Benzocaine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 1994-09-7, 94-09-7 2337
6
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
7 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1
8 Anticonvulsants Phase 4,Phase 2,Phase 1,Early Phase 1
9 Etiracetam Phase 4,Phase 1,Phase 2
10 Nootropic Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
12 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2
13 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
14 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
15 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2
16 Anti-Anxiety Agents Phase 4,Phase 2
17 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Phase 1
18 Antimanic Agents Phase 4,Phase 2,Phase 1
19 GABA Agents Phase 4,Phase 2,Phase 1
20 Neuroprotective Agents Phase 4,Phase 2,Phase 1
21 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1
23 Tranquilizing Agents Phase 4,Phase 2,Phase 1
24 Glutamic Acid Nutraceutical Phase 4
25
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
26
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
27
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
28
Levoleucovorin Approved Phase 3,Phase 2,Phase 1 68538-85-2
29
Lomustine Approved Phase 3,Phase 2,Phase 1 13010-47-4 3950
30
Mechlorethamine Approved Phase 3,Phase 2,Phase 1 51-75-2 4033
31
Methotrexate Approved Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
32
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
33
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
34
Carmustine Approved Phase 3,Phase 1,Phase 2 154-93-8 2578
35
Procarbazine Approved Phase 3,Phase 2,Phase 1 671-16-9 4915
36
Trioxsalen Approved Phase 3,Phase 2,Phase 1 3902-71-4 5585
37
Carboplatin Approved Phase 3,Phase 2,Phase 1,Early Phase 1 41575-94-4 10339178 498142 38904
38
Tranexamic Acid Approved Phase 3 1197-18-8 5526
39
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
40
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
41
Thiotepa Approved Phase 3,Phase 2,Phase 1 52-24-4 5453
42
Melphalan Approved Phase 2, Phase 3,Phase 1 148-82-3 4053 460612
43
Aminolevulinic acid Approved Phase 3,Phase 2,Phase 1 106-60-5 137
44
Bevacizumab Approved, Investigational Phase 2, Phase 3, Phase 1, Early Phase 1 216974-75-3
45
Isotretinoin Approved Phase 3,Phase 2,Phase 1 4759-48-2 5538 5282379
46
Dalteparin Approved Phase 3,Phase 2 9041-08-1
47
Heparin Approved, Investigational Phase 3,Phase 2 9005-49-6 772 46507594
48
Thioguanine Approved Phase 3,Phase 2 154-42-7 2723601
49
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
50
Leflunomide Approved, Investigational Phase 3,Phase 2 75706-12-6 3899

Interventional clinical trials:

(show top 50) (show all 1300)
id Name Status NCT ID Phase
1 Correlation Between SV2A Expression in Tumour Tissue and Efficacy of Levetiracetam in Glioma Patients With Epilepsy Unknown status NCT00454935 Phase 4
2 Light Sedation or Intubated General Anesthesia in Patients With Brain Cancer Undergoing Craniotomy Recruiting NCT02193568 Phase 4
3 Perampanel in Seizure Patients With Primary Glial Brain Tumors Recruiting NCT02363933 Phase 4
4 Supra-early Post-Surgery Chemotherapy in the Treatment on GBM Patients Recruiting NCT02520635 Phase 4
5 Seizure Treatment in Glioma Not yet recruiting NCT03048084 Phase 4
6 Post-approval Study of NovoTTF-100A in Recurrent GBM Patients Terminated NCT01756729 Phase 4
7 Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas Unknown status NCT00278278 Phase 3
8 Surgery, Radiation Therapy, and Chemotherapy With or Without Photodynamic Therapy in Treating Patients With Newly Diagnosed or Recurrent Malignant Supratentorial Gliomas Unknown status NCT00003788 Phase 3
9 Carboplatin Plus Vincristine in Treating Children and Adolescents With Low Grade Glioma Unknown status NCT00003015 Phase 3
10 Cognitive Rehabilitation of Glioma Patients Unknown status NCT00256425 Phase 3
11 SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors Unknown status NCT00517959 Phase 3
12 Efficacy of Tranexamic Acid in Brain Tumor Resections Unknown status NCT01655927 Phase 3
13 Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors Unknown status NCT00392886 Phase 3
14 Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma Unknown status NCT00053872 Phase 3
15 Efficacy and Safety Study of Lomustine/Temozolomide Combination Therapy vs. Standard Therapy for Glioblastoma Patients Unknown status NCT01149109 Phase 3
16 Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors Unknown status NCT00179803 Phase 2, Phase 3
17 Radiation Therapy in Treating Patients With Brain Cancer Completed NCT00002620 Phase 3
18 Hypofractionated Radiotherapy Versus Conventional Radiotherapy in Diffuse Brainstem Glioma in Children Completed NCT01635140 Phase 3
19 High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas Completed NCT00078988 Phase 3
20 High Light and Low Light Dose PDT in Glioma Completed NCT00118222 Phase 3
21 Radiation Therapy or Temozolomide in Treating Patients With Gliomas Completed NCT00182819 Phase 3
22 Standard Radiation Therapy With or Without Stereotactic Radiation Therapy in Treating Patients With Glioma Completed NCT00003916 Phase 3
23 Fluorescence-guided Resection of Malignant Gliomas With 5-Aminolevulinic Acid Completed NCT00241670 Phase 3
24 Dalteparin Low Molecular Weight Heparin for Primary Prophylaxis of Venous Thromboembolism in Brain Tumour Patients Completed NCT00135876 Phase 3
25 Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma Completed NCT00052455 Phase 3
26 Standard Radiation Therapy, Higher-Dose Radiation Therapy, or Chemotherapy in Treating Older Patients With Glioblastoma Multiforme Completed NCT00820963 Phase 3
27 Radiotherapy for Malignant Astrocytomas in the Elderly Completed NCT00430911 Phase 3
28 Radiation Therapy With and Without Combination Chemotherapy in Patients With Resected Anaplastic Oligodendroglioma Completed NCT00002840 Phase 3
29 Radiation Therapy With or Without Chemotherapy in Treating Patients With Anaplastic Oligodendroglioma Completed NCT00002569 Phase 3
30 Combination Chemotherapy in Treating Children With Progressive Brain Tumors Completed NCT00002944 Phase 3
31 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3
32 Phase III Trial of Primary Radio- or Chemotherapy in Malignant Astrocytoma of the Elderly Completed NCT01502241 Phase 3
33 SU-101 Compared With Procarbazine in Treating Patients With Glioblastoma Multiforme Completed NCT00003293 Phase 3
34 Enzastaurin Versus Lomustine in Glioblastoma Completed NCT00295815 Phase 3
35 Comparison of TransMID vs Standard Treatment of Cancerous Brain Tumors Completed NCT00088400 Phase 3
36 Radiation Therapy With or Without Temozolomide in Treating Older Patients With Newly Diagnosed Glioblastoma Multiforme Completed NCT00482677 Phase 3
37 Radiation Therapy (RT) and Temozolomide (TMZ) in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma Completed NCT00304031 Phase 3
38 Radiation Therapy With or Without Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Completed NCT00006353 Phase 3
39 Radiation Therapy Plus Chemotherapy in Treating Patients With Supratentorial Glioblastoma Multiforme Completed NCT00002545 Phase 3
40 S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma Completed NCT00017147 Phase 3
41 An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation Completed NCT00132704 Phase 3
42 Radiation Therapy Plus Combination Chemotherapy in Treating Children With Medulloblastoma Completed NCT00002875 Phase 3
43 Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma Completed NCT01480479 Phase 3
44 The PRECISE Trial: Study of IL13-PE38QQR Compared to GLIADEL Wafer in Patients With Recurrent Glioblastoma Multiforme Completed NCT00076986 Phase 3
45 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
46 Study of IV Edotecarin Vs Temozolomide or Carmustine (BCNU) or Lomustine (CCNU) in Patients With Glioblastoma Multiforme Completed NCT00068952 Phase 3
47 Clinical Trial to Assess the Efficacy and Safety of 'INNOCELL Immuncell-LC' With Temozolomide in Newly Diagnosed Glioblastoma of Korea Completed NCT00807027 Phase 3
48 Cediranib in Combination With Lomustine Chemotherapy in Recurrent Glioblastoma Completed NCT00777153 Phase 3
49 Study of Imatinib Mesylate in Combination With Hydroxyurea Versus Hydroxyurea Alone as an Oral Therapy in Patients With Temozolomide Resistant Progressive Glioblastoma Completed NCT00154375 Phase 3
50 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3

Search NIH Clinical Center for Brain Glioma

Genetic Tests for Brain Glioma

Genetic tests related to Brain Glioma:

id Genetic test Affiliating Genes
1 Glioma of Brain 29

Anatomical Context for Brain Glioma

MalaCards organs/tissues related to Brain Glioma:

39
Brain, Bone, T Cells, Testes, Monocytes, Endothelial, Bone Marrow

Publications for Brain Glioma

Articles related to Brain Glioma:

(show top 50) (show all 148)
id Title Authors Year
1
Lactoferrin-coated polysaccharide nanoparticles based on chitosan hydrochloride/hyaluronic acid/PEG for treating brain glioma. ( 27987946 )
2017
2
Development of a novel imaging agent using peptide-coated gold nanoparticles toward brain glioma stem cell marker CD133. ( 27721007 )
2017
3
Cerebral schistosomiasis: diffusion-weighted imaging helps to differentiate from brain glioma and metastasis. ( 28090792 )
2017
4
Synergistic Combination of Doxorubicin and Paclitaxel Delivered by Blood Brain Barrier and Glioma Cells Dual Targeting Liposomes for Chemotherapy of Brain Glioma. ( 27033513 )
2016
5
IVIM perfusion fraction is prognostic for survival in brain glioma. ( 27116215 )
2016
6
Targeting vincristine plus tetrandrine liposomes modified with DSPE-PEG2000-transferrin in treatment of brain glioma. ( 27644895 )
2016
7
Multifunctional targeting vinorelbine plus tetrandrine liposomes for treating brain glioma along with eliminating glioma stem cells. ( 27029055 )
2016
8
Destruction of vasculogenic mimicry channels by targeting epirubicin plus celecoxib liposomes in treatment of brain glioma. ( 27042063 )
2016
9
c(RGDyK)-decorated Pluronic micelles for enhanced doxorubicin and paclitaxel delivery to brain glioma. ( 27143884 )
2016
10
Dual-targeting superparamagnetic iron oxide nanoprobes with high and low target density for brain glioma imaging. ( 26874270 )
2016
11
Slit2 and Robo1 expression as biomarkers for assessing prognosis in brain glioma patients. ( 27916173 )
2016
12
Conjugation Magnetic PAEEP-PLLA Nanoparticles with Lactoferrin as a Specific Targeting MRI Contrast Agent for Detection of Brain Glioma in Rats. ( 27119155 )
2016
13
Malignant transformation of bone marrow stromal cells induced by the brain glioma niche in rats. ( 26590986 )
2016
14
Molecular and clinical characterization of PD-L1 expression at transcriptional level via 976 samples of brain glioma. ( 27999734 )
2016
15
Circulating tumor cell is a common property of brain glioma and promotes the monitoring system. ( 27517490 )
2016
16
GFAP expression is regulated by Pax3 in brain glioma stem cells. ( 27432276 )
2016
17
Asn-Gly-Arg-modified polydopamine-coated nanoparticles for dual-targeting therapy of brain glioma in rats. ( 27655664 )
2016
18
IDH1/2 Mutation and MGMT Promoter Methylation - the Relevant Survival Predictors in Czech Patients with Brain Gliomas. ( 27978414 )
2016
19
Upregulation of miR-183 expression and its clinical significance in human brain glioma. ( 27215622 )
2016
20
Noninvasive In Vivo Diagnosis of Brain Glioma Using RGD-Decorated Fluorescent Carbonaceous Nanospheres. ( 26510309 )
2015
21
Comparison of 4'-[methyl-(11)C]thiothymidine ((11)C-4DST) and 3'-deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) PET/CT in human brain glioma imaging. ( 25853013 )
2015
22
Establishment of C6 brain glioma models through stereotactic technique for laser interstitial thermotherapy research. ( 25883843 )
2015
23
Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semisolid magnetization transfer reference (EMR) signals: II. Comparison of three EMR models and application to human brain glioma at 3 Tesla. ( 26033553 )
2015
24
Diagnostic significance of intraoperative ultrasound contrast in evaluating the resection degree of brain glioma by transmission electron microscopic examination. ( 25591560 )
2015
25
Expression of metastasis-associated protein 3 in human brain glioma related to tumor prognosis. ( 26002011 )
2015
26
3D multimodal MRI brain glioma tumor and edema segmentation: a graph cut distribution matching approach. ( 25467804 )
2015
27
Brain glioma growth model using reaction-diffusion equation with viscous stress tensor on brain MR images. ( 26518060 )
2015
28
The expression of P2Xa88 receptors in EPCs and their potential role in the targeting of EPCs to brain gliomas. ( 25839324 )
2015
29
UPA-sensitive ACPP-conjugated nanoparticles for multi-targeting therapy of brain glioma. ( 25443789 )
2015
30
The expression of p53, mgmt and egfr in brain glioma and clinical significance. ( 25864751 )
2015
31
Effects of HMGB1 on proliferation and apoptosis of human brain glioma CD133 cells. ( 26350087 )
2015
32
Non-model segmentation of brain glioma tissues with the combination of DWI and fMRI signals. ( 26405892 )
2015
33
Lactoferrin conjugated iron oxide nanoparticles for targeting brain glioma cells in magnetic particle imaging. ( 26412614 )
2015
34
Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells. ( 25153726 )
2014
35
Personal history of diabetes, genetic susceptibility to diabetes, and risk of brain glioma: a pooled analysis of observational studies. ( 24220915 )
2014
36
Differences of SiHa (human cancer of cervix) and BMG-1 (brain glioma) cell lines as 2D and 3D cultures. ( 23881600 )
2014
37
Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma. ( 24726749 )
2014
38
Molecular and metabolic pattern classification for detection of brain glioma progression. ( 24321226 )
2014
39
Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase. ( 24399197 )
2014
40
Synergistic dual-ligand doxorubicin liposomes improve targeting and therapeutic efficacy of brain glioma in animals. ( 24893333 )
2014
41
Relationship of 14-3-3zeta (IP), HIF-1I+, and VEGF expression in human brain gliomas. ( 23358800 )
2014
42
EGFP-EGF1-conjugated nanoparticles for targeting both neovascular and glioma cells in therapy of brain glioma. ( 24529623 )
2014
43
Terahertz pulsed spectroscopy of paraffin-embedded brain glioma. ( 25003757 )
2014
44
OX26/CTX-conjugated PEGylated liposome as a dual-targeting gene delivery system for brain glioma. ( 25128329 )
2014
45
Evaluation of Prognostic Integrin I+2I^1 PET Tracer and Concurrent Targeting Delivery Using Focused Ultrasound for Brain Glioma Detection. ( 25153169 )
2014
46
Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment. ( 23932498 )
2013
47
Cytotoxic activity of ex-vivo generated IFNI+-induced monocyte-derived dendritic cells in brain glioma patients. ( 23973877 )
2013
48
Transferrin-modified Doxorubicin-loaded biodegradable nanoparticles exhibit enhanced efficacy in treating brain glioma-bearing rats. ( 23786401 )
2013
49
Inhibition of I'-opioid receptors induces brain glioma cell apoptosis through the mitochondrial and protein kinase C pathways. ( 24179523 )
2013
50
Characteristics of sequential targeting of brain glioma for transferrin-modified cisplatin liposome. ( 23347891 )
2013

Variations for Brain Glioma

Expression for Brain Glioma

Search GEO for disease gene expression data for Brain Glioma.

Pathways for Brain Glioma

Pathways related to Brain Glioma according to GeneCards Suite gene sharing:

(show all 18)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.59 BMP2 BMP4 EGFR FASLG GFAP NOTCH1
2
Show member pathways
13.17 BMP2 BMP4 EGFR FASLG NUDT6 TP53
3
Show member pathways
12.86 BMP2 BMP4 EGFR FASLG NOTCH1 NUDT6
4
Show member pathways
12.8 BMP2 BMP4 EGFR NUDT6 TP53
5
Show member pathways
12.48 BMP2 BMP4 EGFR NUDT6
6 11.95 BMP2 BMP4 EGFR FASLG TP53
7 11.84 BMP4 NES NOTCH1
8 11.75 EGFR GFAP TP53
9 11.72 BMP4 NOTCH1 TP53
10 11.69 FASLG HMGB1 TP53
11 11.65 EGFR MGMT TP53
12 11.59 BMP4 GFAP NOTCH1
13 11.36 BMP2 BMP4 EGFR NUDT6
14 11.14 EGFR FASLG TP53
15 10.99 BMP2 BMP4 NOTCH1
16 10.97 BMP2 BMP4
17 10.92 BMP2 BMP4 GFAP NES NOTCH1
18 10.91 BMP2 BMP4

GO Terms for Brain Glioma

Cellular components related to Brain Glioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 BMP2 EGFR FASLG HMGB1 NOTCH1

Biological processes related to Brain Glioma according to GeneCards Suite gene sharing:

(show all 41)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.99 BMP2 BMP4 EGFR NOTCH1 TP53
2 negative regulation of cell proliferation GO:0008285 9.98 BMP2 BMP4 NOTCH1 TP53
3 negative regulation of transcription, DNA-templated GO:0045892 9.95 BMP2 BMP4 MYBBP1A NOTCH1 TP53
4 positive regulation of protein phosphorylation GO:0001934 9.86 BMP2 BMP4 EGFR
5 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.85 BMP2 BMP4 FASLG HMGB1 NOTCH1 TP53
6 osteoblast differentiation GO:0001649 9.83 BMP2 BMP4 MYBBP1A
7 ossification GO:0001503 9.81 BMP2 BMP4 EGFR
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 BMP2 BMP4 EGFR HMGB1
9 positive regulation of epithelial cell proliferation GO:0050679 9.71 BMP4 EGFR NOTCH1
10 positive regulation of cell migration GO:0030335 9.71 BMP2 BMP4 EGFR NOTCH1
11 negative regulation of cell death GO:0060548 9.7 BMP4 MGMT NOTCH1
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.68 EGFR HMGB1
13 negative regulation of myoblast differentiation GO:0045662 9.68 BMP4 NOTCH1
14 positive regulation of cartilage development GO:0061036 9.67 BMP2 BMP4
15 endocardial cushion morphogenesis GO:0003203 9.67 BMP2 NOTCH1
16 positive regulation of wound healing GO:0090303 9.67 HMGB1 KANK1
17 positive regulation of ossification GO:0045778 9.66 BMP2 BMP4
18 cardiac epithelial to mesenchymal transition GO:0060317 9.65 BMP2 NOTCH1
19 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.65 BMP4 NOTCH1
20 inflammatory response to antigenic stimulus GO:0002437 9.65 HMGB1 NOTCH1
21 cell fate commitment GO:0045165 9.65 BMP2 BMP4 NOTCH1
22 cardiac muscle tissue morphogenesis GO:0055008 9.64 BMP2 NOTCH1
23 endocardial cushion development GO:0003197 9.63 BMP4 NOTCH1
24 positive regulation of endothelial cell differentiation GO:0045603 9.63 BMP4 NOTCH1
25 cellular response to growth factor stimulus GO:0071363 9.63 BMP2 BMP4 EGFR
26 positive regulation of catenin import into nucleus GO:0035413 9.62 EGFR KANK1
27 atrioventricular valve morphogenesis GO:0003181 9.62 BMP2 NOTCH1
28 positive regulation of astrocyte differentiation GO:0048711 9.61 BMP2 NOTCH1
29 pulmonary valve morphogenesis GO:0003184 9.6 BMP4 NOTCH1
30 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.58 BMP4 EGFR
31 chromatin assembly GO:0031497 9.58 HMGB1 TP53
32 telencephalon regionalization GO:0021978 9.56 BMP2 BMP4
33 aortic valve morphogenesis GO:0003180 9.51 BMP4 NOTCH1
34 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.49 BMP2 BMP4
35 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 9.33 BMP2 BMP4 TP53
36 mesenchymal cell proliferation involved in ureteric bud development GO:0072138 9.32 BMP2 BMP4
37 BMP signaling pathway involved in heart induction GO:0003130 9.26 BMP2 BMP4
38 lung development GO:0030324 9.26 BMP4 EGFR HMGB1 NOTCH1
39 positive regulation of apoptotic process GO:0043065 9.1 BMP2 BMP4 FASLG HMGB1 NOTCH1 TP53
40 multicellular organism development GO:0007275 10.08 BMP2 BMP4 EGFR NES NOTCH1 TP53
41 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.04 BMP2 BMP4 EGFR HMGB1 NOTCH1 TP53

Molecular functions related to Brain Glioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.43 BMP2 BMP4 NUDT6
2 co-receptor binding GO:0039706 9.16 BMP2 BMP4
3 BMP receptor binding GO:0070700 8.96 BMP2 BMP4
4 cytokine activity GO:0005125 8.92 BMP2 BMP4 FASLG HMGB1

Sources for Brain Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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