Aliases & Classifications for Brain Glioma

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Brain Glioma, Aliases & Descriptions:

Name: Brain Glioma 9 11 22
Intracranial Glioma 60
 
Lower Grade Glioma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:0060108

Summaries for Brain Glioma

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Disease Ontology:9 A brain cancer that has material basis in glial cells.

MalaCards based summary: Brain Glioma, also known as intracranial glioma, is related to glioblastoma and osteochondroma. An important gene associated with Brain Glioma is MYBBP1A (MYB binding protein (P160) 1a), and among its related pathways are Selected targets of Oct 3 4 and TGF-beta Signaling Pathway. The compounds titanium and fluvastatin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related mouse phenotypes are hearing/vestibular/ear and embryogenesis.

Related Diseases for Brain Glioma

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Diseases related to Brain Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1glioblastoma30.2NES, STAT6, GJA1
2osteochondroma10.4BMP2
3malignant peripheral nerve sheath tumor10.2NES, BMP2
4colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas10.2BMP4, BMP2
5cerebritis10.2
6hypoxia10.2
7fibrodysplasia ossificans progressiva10.2BMP4, BMP2
8osseous heteroplasia, progressive10.2BMP4, BMP2
9leiomyoma10.1GJA1, NES
10bone cancer10.1BMP2, BMP4
11pulmonary hypertension10.1BMP4, BMP2
12secondary syphilis10.1BMP4, BMP2
13cleft palate, isolated10.1BMP4, BMP2
14pituitary adenoma10.1BMP4, NES
15rhabdomyosarcoma10.0NES, BMP4, GJA1
16malignant glioma10.0
17brain oligodendroglioma10.0
18stomach cancer10.0
19endotheliitis10.0
20stroke, ischemic10.0NES, OCLN
21neurilemmoma10.0BMP4, BMP2, NES
22embryonal cancer10.0BMP4, BMP2, NES
23glioblastoma multiforme10.0GJA1, STAT6, NES
24microvascular complications of diabetes 510.0OCLN, BMP4
25sarcoma10.0BMP4, BMP2, NES
26pancreatic cancer10.0NES, BMP2, GJA1
27lung benign neoplasm10.0BMP2, BMP4, GJA1
28dilated cardiomyopathy9.9STAT6, GJA1
29osteosarcoma, somatic9.9GJA1, BMP4, BMP2
30adenoma9.9NES, BMP4, GJA1
31ovarian cancer, somatic9.8GJA1, BMP4, BMP2
32atherosclerosis9.8BMP4, BMP2, STAT6
33adenocarcinoma9.8NES, BMP2, BMP4, GJA1
34melanoma9.8NES, BMP2, BMP4, GJA1
35colorectal cancer9.7BMP4, BMP2, STAT6
36lung cancer9.7BMP2, BMP4, GJA1
37prostate cancer9.5NES, STAT6, BMP2, BMP4, GJA1
38breast cancer9.5GJA1, BMP4, BMP2, STAT6, NES

Graphical network of the top 20 diseases related to Brain Glioma:



Diseases related to brain glioma

Symptoms for Brain Glioma

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Drugs & Therapeutics for Brain Glioma

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Drug clinical trials:

Search ClinicalTrials for Brain Glioma

Search NIH Clinical Center for Brain Glioma

Genetic Tests for Brain Glioma

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Genetic tests related to Brain Glioma:

id Genetic test Affiliating Genes
1 Glioma of Brain22

Anatomical Context for Brain Glioma

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MalaCards organs/tissues related to Brain Glioma:

31
Brain, Bone, Testes, Cervix, Monocytes, T cells, Endothelial

Animal Models for Brain Glioma or affiliated genes

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MGI Mouse Phenotypes related to Brain Glioma:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.0GJA1, BMP4, BMP2
2MP:00053808.4MYBBP1A, NES, BMP2, BMP4, GJA1
3MP:00053718.3GJA1, BMP4, BMP2, OCLN
4MP:00053848.1NES, STAT6, BMP2, BMP4, GJA1
5MP:00053798.1GJA1, BMP4, STAT6, OCLN
6MP:00053908.1OCLN, BMP2, BMP4, GJA1
7MP:00036317.8OCLN, NES, BMP2, BMP4, GJA1
8MP:00053897.7OCLN, STAT6, BMP2, BMP4, GJA1
9MP:00107687.7MYBBP1A, NES, STAT6, BMP2, BMP4, GJA1
10MP:00053787.4GJA1, BMP4, BMP2, STAT6, NES, OCLN
11MP:00053767.2OCLN, STAT6, BMP2, BMP4, GJA1

Publications for Brain Glioma

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Articles related to Brain Glioma:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Comparison of 4'-[methyl-(11)C]thiothymidine ((11)C-4DST) and 3'-deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) PET/CT in human brain glioma imaging. (25853013)
2015
2
3D multimodal MRI brain glioma tumor and edema segmentation: a graph cut distribution matching approach. (25467804)
2015
3
Diagnostic significance of intraoperative ultrasound contrast in evaluating the resection degree of brain glioma by transmission electron microscopic examination. (25591560)
2015
4
The expression of p53, mgmt and egfr in brain glioma and clinical significance. (25864751)
2015
5
Terahertz pulsed spectroscopy of paraffin-embedded brain glioma. (25003757)
2014
6
Personal history of diabetes, genetic susceptibility to diabetes, and risk of brain glioma: a pooled analysis of observational studies. (24220915)
2014
7
Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma. (24726749)
2014
8
OX26/CTX-conjugated PEGylated liposome as a dual-targeting gene delivery system for brain glioma. (25128329)
2014
9
The safety and efficacy of magnetic nano-iron hyperthermia therapy on rat brain glioma. (24163108)
2013
10
Characteristics of sequential targeting of brain glioma for transferrin-modified cisplatin liposome. (23347891)
2013
11
Mathematical modeling of brain glioma growth using modified reaction-diffusion equation on brain MR images. (24290915)
2013
12
Low intensity ultrasound promotes the sensitivity of rat brain glioma to Doxorubicin by down-regulating the expressions of p-glucoprotein and multidrug resistance protein 1 in vitro and in vivo. (23940624)
2013
13
In vivo intracellular oxygen dynamics in murine brain glioma and immunotherapeutic response of cytotoxic T cells observed by fluorine-19 magnetic resonance imaging. (23667419)
2013
14
Enhancement in a brain glioma model: a comparison of half-dose gadobenate dimeglumine versus full-dose gadopentetate dimeglumine at 1.5 and 3 T. (23737259)
2013
15
MicroRNA-34a inhibits human brain glioma cell growth by down-regulation of Notch1. (22684560)
2012
16
Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment. (22019122)
2012
17
Human brain glioma stem cells are more invasive than their differentiated progeny cells in vitro. (22153826)
2012
18
Compartment- and malignance-dependent up-regulation of I^-glutamyltranspeptidase and dipetidylpeptidase-IV activity in human brain gliomas. (22648548)
2012
19
Liposome formulated with TAT-modified cholesterol for improving brain delivery and therapeutic efficacy on brain glioma in animals. (21945185)
2011
20
Angiopep-conjugated poly(ethylene glycol)-co-poly(I/-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma. (21427009)
2011
21
Single nucleotide polymorphisms in IL-4Ra, IL-13 and STAT6 genes occurs in brain glioma. (21196282)
2011
22
Effect of bone morphogenetic protein 4 in the human brain glioma cell line U251. (20730570)
2010
23
Development of transferrin functionalized poly(ethylene glycol)/poly(lactic acid) amphiphilic block copolymeric micelles as a potential delivery system targeting brain glioma. (20535631)
2010
24
Evaluation of gadodiamide versus gadobutrol for contrast-enhanced MR imaging in a rat brain glioma model at 1.5 and 3 T. (20856127)
2010
25
Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines. (20024601)
2010
26
YY1 Over-expression in human brain gliomas and meningiomas correlates with TGF-beta1, IGF-1 and FGF-2 mRNA levels. (19235591)
2009
27
Grading of brain glioma with 1-11C-acetate PET: comparison with 18F-FDG PET. (18312826)
2008
28
Contribution of cortical and subcortical electrostimulation in brain glioma surgery: methodological and functional considerations. (18083492)
2007
29
Cytogenetic analyses in 81 patients with brain gliomas: correlation with clinical outcome and morphological data. (17569001)
2007
30
Chemoresistance of CD133(+) tumor stem cells from human brain glioma]. (17767043)
2007
31
Degree prediction of malignancy in brain glioma using support vector machines. (16446164)
2006
32
Isolation and culture of tumor stem cells from human brain glioma tissues]. (17044993)
2006
33
Research on relationship of survivin gene expression with malignant proliferation and apoptosis of brain glioma]. (16083611)
2005
34
Expression of cyclin D1 in brain gliomas and its significance]. (14720377)
2004
35
Diagnosis of brain gliomas in stereotactic biopsy assisted by optical neuro-navigation system]. (15049161)
2004
36
Radioimmunotherapy as a novel treatment regimen: 125I-labeled monoclonal antibody 425 in the treatment of high-grade brain gliomas. (14967458)
2004
37
Pimonidazole binding in C6 rat brain glioma: relation with lipid droplet detection. (12778075)
2003
38
Multiple suppressor gene p16 of human brain gliomas. (12411158)
2002
39
Experiment and observation on invasion of brain glioma in vivo. (12604281)
2002
40
Role gene expression changes in development of human brain gliomas]. (12214508)
2002
41
Brain glioma and human leukocyte antigens (HLA)--is there an association. (11519856)
2001
42
Expression and significance of urokinase type plasminogen activator gene in human brain gliomas. (10914816)
2000
43
Expression of PECAM-1/CD31 isoforms in human brain gliomas. (10448867)
1999
44
Reduced connexin43 expression in high-grade human brain glioma cells. (9989416)
1999
45
Interaction between microwave-induced brain hyperthermia and high dose rate radiation in the BT4 An brain glioma in rats. (8847553)
1996
46
Experimental brain glioma: growth arrest and destruction by a blood-group-related tetrasaccharide. (8786375)
1996
47
T1 snapshot FLASH measurement of rat brain glioma: kinetics of the tumor-enhancing contrast agent manganese (III) tetraphenylporphine sulfonate. (1461108)
1992
48
Expression of the preproenkephalin A gene in tumor cells and brain glioma: a northern and in situ hybridization study. (2739883)
1989
49
Antibody guided irradiation of brain glioma by arterial infusion of radioactive monoclonal antibody against epidermal growth factor receptor and blood group A antigen. (2986752)
1985
50
Effect of CCNU on survival, rate of objective remission and duration of free interval in patients with malignant brain glioma--first evaluation. (1269526)
1976

Variations for Brain Glioma

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Expression for genes affiliated with Brain Glioma

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Search GEO for disease gene expression data for Brain Glioma.

Pathways for genes affiliated with Brain Glioma

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Compounds for genes affiliated with Brain Glioma

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Compounds related to Brain Glioma according to GeneCards Suite gene sharing:

(show all 29)
idCompoundScoreTop Affiliating Genes
1titanium439.7BMP4, BMP2
2fluvastatin43 49 28 1212.7GJA1, BMP2
3deoxyribonucleic acid439.7BMP2, BMP4
4guanidine hydrochloride439.6BMP2, BMP4
5dbc-amp439.6BMP4, GJA1
61,25 dihydroxy vitamin d3439.5GJA1, BMP2
7bromodeoxyuridine439.4GJA1, BMP4, NES
8azathioprine43 2 49 1212.3BMP2, BMP4
9ribonucleic acid439.3GJA1, BMP4, BMP2
10dopamine43 28 24 1212.3BMP4, BMP2, NES
11forskolin43 49 1211.2GJA1, BMP4, BMP2
12pge2439.2BMP2, BMP4, GJA1
13thymidine43 2410.2GJA1, BMP4, BMP2
14actinomycin d439.1STAT6, BMP2, BMP4
15matrigel438.9NES, BMP2, BMP4, GJA1
16progesterone43 28 59 24 1212.9NES, BMP2, BMP4, GJA1
17vegf438.9NES, BMP2, BMP4, GJA1
18nitric oxide43 24 1210.9NES, BMP2, BMP4, GJA1
19estrogen438.9NES, BMP2, BMP4, GJA1
20steroid438.8BMP4, BMP2, STAT6
21retinoid438.7GJA1, BMP4, BMP2, STAT6
22sb 20358043 599.7STAT6, BMP2, BMP4, GJA1
23pd 98,059438.7GJA1, BMP4, BMP2, STAT6
24cycloheximide438.7STAT6, BMP2, BMP4, GJA1
25dexamethasone43 49 28 1211.7GJA1, BMP4, BMP2, STAT6
26oligonucleotide438.5BMP4, BMP2, STAT6
27serine438.5GJA1, BMP4, BMP2, STAT6
28retinoic acid43 249.3NES, STAT6, BMP2, BMP4, GJA1
29tyrosine438.3NES, STAT6, BMP2, BMP4, GJA1

GO Terms for genes affiliated with Brain Glioma

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Biological processes related to Brain Glioma according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1BMP signaling pathway involved in heart inductionGO:00031309.8BMP4, BMP2
2mesenchymal cell proliferation involved in ureteric bud developmentGO:00721389.8BMP4, BMP2
3telencephalon regionalizationGO:00219789.8BMP4, BMP2
4regulation of odontogenesis of dentin-containing toothGO:00424879.8BMP2, BMP4
5positive regulation of cartilage developmentGO:00610369.8BMP4, BMP2
6positive regulation of ossificationGO:00457789.8BMP4, BMP2
7SMAD protein signal transductionGO:00603959.8BMP2, BMP4
8telencephalon developmentGO:00215379.7BMP2, BMP4
9positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.7BMP4, BMP2
10positive regulation of bone mineralizationGO:00305019.7BMP2, BMP4
11chondrocyte differentiationGO:00020629.7BMP4, BMP2
12negative regulation of cell cycleGO:00457869.7BMP4, BMP2
13branching involved in ureteric bud morphogenesisGO:00016589.7BMP2, BMP4
14osteoblast differentiationGO:00016499.7BMP4, BMP2
15positive regulation of osteoblast differentiationGO:00456699.7BMP4, BMP2
16BMP signaling pathwayGO:00305099.6BMP4, BMP2
17odontogenesis of dentin-containing toothGO:00424759.6BMP4, BMP2
18positive regulation of endothelial cell proliferationGO:00019389.5BMP2, BMP4
19positive regulation of neuron differentiationGO:00456669.5BMP4, BMP2
20positive regulation of ERK1 and ERK2 cascadeGO:00703749.3BMP2, BMP4
21negative regulation of transcription, DNA-templatedGO:00458929.3MYBBP1A, BMP2, BMP4
22positive regulation of protein phosphorylationGO:00019349.1BMP4, BMP2
23negative regulation of transcription from RNA polymerase II promoterGO:00001228.8BMP4, BMP2, STAT6
24positive regulation of transcription from RNA polymerase II promoterGO:00459448.8BMP4, BMP2, STAT6

Molecular functions related to Brain Glioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1BMP receptor bindingGO:00707009.1BMP4, BMP2
2protein bindingGO:00055157.2GJA1, BMP4, BMP2, STAT6, MYBBP1A, OCLN

Products for genes affiliated with Brain Glioma

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Sources for Brain Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet