MCID: BRN032
MIFTS: 50

Brain Glioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Brain Glioma

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32MalaCards
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MalaCards: Brain Glioma, also known as glial tumor of brain, is related to malignant glioma and brain stem glioma. An important gene associated with Brain Glioma is GJA1 (gap junction protein, alpha 1, 43kDa), and among its related pathways are Cell adhesion Endothelial cell contacts by junctional mechanisms and Leukocyte transendothelial migration. The compounds resveratrol and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and testes, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Aliases & Classifications for Brain Glioma

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8Disease Ontology, 22GTR, 10DISEASES, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain glioma 8 22 10
glial tumor of brain 60


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Disease Ontology8 DOID:0060108

Related Diseases for Brain Glioma

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17GeneCards, 18GeneDecks
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Diseases related to Brain Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1malignant glioma30.7BSG, NES, PCNA, MMP14, GJA1, BIRC5
2brain stem glioma30.6BSG
3brain cancer30.4NES, MMP14, GJA1, BIRC5, VCAN, PECAM1
4meningioma29.9PCNA
5stomach cancer29.9BIRC5, NME1, MMP14, PCNA, BMP2
6cerebritis10.1
7neuroblastoma10.0NME1
8tuberous sclerosis10.0NES
9peritonitis10.0PECAM1
10inflammatory bowel disease10.0OCLN
11fibrosarcoma10.0MMP14, NES
12endometriosis10.0BSG, MMP14
13anaplastic large cell lymphoma10.0BSG
14vascular disease10.0GJA1, PCNA
15gastrointestinal stromal tumor10.0NES, PCNA
16pituitary tumors10.0BMP2
17endometrial carcinoma10.0NME1, MMP14, PCNA
18bladder carcinoma10.0BSG, PCNA
19pituitary adenoma10.0PCNA, NES
20smooth muscle tumor10.0NME1, PCNA
21myocardial infarction10.0PECAM1, GJA1
22cervical intraepithelial neoplasia10.0YY1, BIRC5, NME1
23papilloma10.0GJA1, PCNA
24cervical cancer10.0MMP14, NME1, BIRC5, YY1
25rhabdomyosarcoma10.0NES, MMP14, GJA1
26cervical squamous cell carcinoma10.0MMP14
27leiomyoma10.0BSG, NES, PCNA, GJA1
28uterine fibroid10.0BSG, PCNA, GJA1
29lung benign neoplasm10.0BMP2, EPHA2, GJA1, PECAM1
30laryngeal benign neoplasm10.0BSG, PCNA, MMP14, NME1
31laryngeal squamous cell carcinoma10.0BSG, PCNA, NME1, BIRC5
32medulloblastoma10.0BMP2, NES, VCAN
33adenoma10.0NES, PCNA, GJA1, NME1, BIRC5
34sarcoma10.0BMP2, NES, EPHA2, YBX1, PECAM1
35brain ischemia10.0NES
36esophageal cancer10.0PCNA, MMP14, NME1
37non-small cell lung carcinoma10.0BMP2, PCNA, NME1, BIRC5
38ischemia10.0PECAM1, GJA1, MMP14, NES, BSG
39nasopharynx carcinoma10.0NME1, GJA1, PCNA
40arthritis10.0BMP2, STAT6, MMP14, PECAM1
41hypertrophy of breast10.0YY1, GJA1, NES, STAT6, BMP2
42anaplastic astrocytoma10.0PCNA, NES, BSG
43transitional cell carcinoma10.0BSG, PCNA, MMP14, NME1, BIRC5
44myeloma10.0BIRC5, BMP2
45colorectal cancer10.0PCNA, EPHA2, MMP14, NME1, BIRC5
46pancreatic cancer10.0NES, MMP14, BIRC5
47retinoblastoma10.0YY1, BIRC5, NME1, PCNA, BMP2
48rheumatoid arthritis10.0BMP2, BSG, STAT6, MMP14, PECAM1
49cadasil10.0PECAM1, GJA1, NES, BSG
50astrocytoma10.0BSG, NES, PCNA, MMP14, GJA1, TSC22D1

Graphical network of the top 20 diseases related to Brain Glioma:



Diseases related to brain glioma

Clinical Features for Brain Glioma

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Drugs & Therapeutics for Brain Glioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Brain Glioma

Drug clinical trials:

Search ClinicalTrials for Brain Glioma

Search NIH Clinical Center for Brain Glioma

Search CenterWatch for Brain Glioma

Genetic Tests for Brain Glioma

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22GTR
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Genetic tests related to Brain Glioma:

id Genetic test Affiliating Genes
1 Glioma of Brain22

Anatomical Context for Brain Glioma

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32MalaCards
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MalaCards organs/tissues related to Brain Glioma:

32
Brain, Endothelial, Testes, Fetal brain, T cells, Bone, Monocytes, Spinal cord, Cervix, Pons

Animal Models for Brain Glioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Brain Glioma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.4VCAN
2MP:000538810.0STAT6, YBX1, MMP14, GJA1, YY1, PECAM1
3MP:000539010.0BMP2, OCLN, EPHA2, MMP14, GJA1, VCAN
4MP:00028739.7EPHA2, MMP14, GJA1, BIRC5, VCAN, YY1
5MP:00053809.6RFX4, BMP2, NES, MYBBP1A, EPHA2, YBX1
6MP:00053769.5BMP2, STAT6, OCLN, EPHA2, YBX1, MMP14
7MP:00053859.5BMP2, EPHA2, CLDN5, YBX1, MMP14, GJA1
8MP:00053789.5BMP2, BSG, STAT6, NES, OCLN, PCNA
9MP:00053849.4BMP2, STAT6, NES, PCNA, YBX1, MMP14
10MP:00036319.4BMP2, NES, OCLN, EPHA2, CLDN5, YBX1
11MP:00053979.3STAT6, PCNA, YBX1, GJA1, NME1, BIRC5
12MP:00107689.1PCNA, MYBBP1A, NES, STAT6, BSG, BMP2

Publications for Brain Glioma

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50PubMed
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Articles related to Brain Glioma:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase. (24399197)
2014
2
c-Src and neural Wiskott-Aldrich syndrome protein (N-WASP) promote low oxygen-induced accelerated brain invasion by gliomas. (24069415)
2013
3
Cytotoxic activity of ex-vivo generated IFNI+-induced monocyte-derived dendritic cells in brain glioma patients. (23973877)
2013
4
Inhibition of I'-opioid receptors induces brain glioma cell apoptosis through the mitochondrial and protein kinase C pathways. (24179523)
2013
5
Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma. (23981365)
2013
6
CCL2-expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo. (22319587)
2012
7
Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells. (22454662)
2012
8
Mda-9/syntenin promotes human brain glioma migration through focal adhesion kinase (FAK)-JNK and FAK-AKT signaling. (22938480)
2012
9
Co-deletion of chromosome 1p/19q and IDH1/2 mutation in glioma subsets of brain tumors in Chinese patients. (22427879)
2012
10
Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain. (21676290)
2011
11
Strengths and weaknesses of 1.5T and 3T MRS data in brain glioma classification. (21427025)
2011
12
A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03. (21377994)
2011
13
Evaluation of a fibrin-binding gadolinium chelate peptide tetramer in a brain glioma model. (21150792)
2011
14
Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion. (21771732)
2011
15
Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study. (20479404)
2010
16
Development of transferrin functionalized poly(ethylene glycol)/poly(lactic acid) amphiphilic block copolymeric micelles as a potential delivery system targeting brain glioma. (20535631)
2010
17
Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines. (20024601)
2010
18
microRNA-34a is tumor suppressive in brain tumors and glioma stem cells. (20190569)
2010
19
Glioma cell populations grouped by different cell type markers drive brain tumor growth. (20460538)
2010
20
Gastrin-releasing peptide receptor content in human glioma and normal brain. (20211708)
2010
21
The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma. (21060663)
2010
22
YY1 Over-expression in human brain gliomas and meningiomas correlates with TGF-beta1, IGF-1 and FGF-2 mRNA levels. (19235591)
2009
23
Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity. (20008733)
2009
24
Nuclear factor I regulates brain fatty acid-binding protein and glial fibrillary acidic protein gene expression in malignant glioma cell lines. (19540848)
2009
25
Brain stem glioma, a rare cause of hearing loss and dysequilibrium. (21063295)
2008
26
Brain surface spindle cell glioma in a patient with medically intractable partial epilepsy: a variant of monomorphous angiocentric glioma? (18179412)
2008
27
Activation of AMP-activated protein kinase by kainic acid mediates brain-derived neurotrophic factor expression through a NF-kappaB dependent mechanism in C6 glioma cells. (18445478)
2008
28
Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells. (19094226)
2008
29
Use of interferon-alpha-induced dendritic cells in the therapy of patients with malignant brain gliomas. (18214316)
2007
30
Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours. (17239010)
2007
31
Stereotactic comparison among cerebral blood volume, methionine uptake, and histopathology in brain glioma. (17353312)
2007
32
Gelatinolytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9 in rat brain after implantation of 9L rat glioma cells. (17437609)
2007
33
Isolation and culture of tumor stem cells from human brain glioma tissues]. (17044993)
2006
34
Biopsy of brain stem glioma using motor-evoked potential mapping by direct peduncular stimulation and individual adjuvant therapy. Case report. (15699622)
2005
35
High-resolution magic-angle-spinning 1H NMR spectroscopy reveals different responses in choline-containing metabolites upon gene therapy-induced programmed cell death in rat brain glioma. (15884096)
2005
36
Diagnosis of brain gliomas in stereotactic biopsy assisted by optical neuro-navigation system]. (15049161)
2004
37
Radioimmunotherapy as a novel treatment regimen: 125I-labeled monoclonal antibody 425 in the treatment of high-grade brain gliomas. (14967458)
2004
38
Relationship between aquaporin-4 expression in astrocytes and brain edema caused by glioma]. (12810377)
2003
39
Expression and significance of urokinase type plasminogen activator gene in human brain gliomas. (10914816)
2000
40
The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene in brain tissues and gliomas. (11050470)
2000
41
Expression of emmprin (CD147), a cell surface inducer of matrix metalloproteinases, in normal human brain and gliomas. (10962435)
2000
42
Moyamoya disease associated with a brain stem glioma. (10855525)
2000
43
Transfection of C6 glioma cells with glia maturation factor upregulates brain-derived neurotrophic factor and nerve growth factor: trophic effects and protection against ethanol toxicity in cerebellar granule cells. (10814733)
2000
44
Application of SPET using technetium-99m sestamibi in brain tumours and comparison with expression of the MDR-1 gene: is it possible to predict the response to chemotherapy in patients with gliomas by means of 99mTc-sestamibi SPET? (9553170)
1998
45
The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors. (7607567)
1995
46
Suramin inhibits glioma cell proliferation in vitro and in the brain. (7699415)
1994
47
Pathological laughter and brain stem glioma. (1640246)
1992
48
Hyperfractionated radiation therapy for brain-stem glioma: a phase I-II trial. (2709109)
1989
49
Orthostatic hypotension with lower brain stem glioma. (7161610)
1982
50
Mixed glioma and rhabdomyosarcoma in brain of a wild deer. (929897)
1977

Genetic Variations for Brain Glioma

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Expression for genes affiliated with Brain Glioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Glioma

Search GEO for disease gene expression data for Brain Glioma.

Pathways for genes affiliated with Brain Glioma

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12EMD Millipore, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Brain Glioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2GJA1, CLDN5, OCLN
210.1PECAM1, CLDN5, OCLN
310.1MMP14, PCNA, BMP2
410.0OCLN, CLDN5, VCAN, PECAM1

Compounds for genes affiliated with Brain Glioma

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Brain Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1resveratrol44 59 11 2413.7BMP2
2cycloheximide4410.7TSC22D1, GJA1
3etoposide44 49 59 1113.7YBX1, GJA1
4nimbolide4410.6PCNA, BIRC5
5polycaprolactone4410.5PECAM1, BMP2
6dbpa4410.5YBX1, PCNA
7alginate4410.5VCAN, MMP14, BMP2
8prinomastat4410.5MMP14, BSG
9glucose4410.5BSG, BIRC5, VCAN, YY1
10p0024410.5MMP14, NME1, BIRC5, PECAM1
11cytochalasin b4410.4BSG, MMP14, BIRC5
12bromodeoxyuridine4410.4GJA1, NES, PCNA, MMP14
13lipofectamine4410.4BIRC5, GJA1
14dmso4410.4NME1, GJA1, NES, BIRC5
15ribonucleic acid4410.4MMP14, GJA1, NME1, PECAM1, BMP2
16calcitriol44 59 11 2413.4NME1, BMP2, MMP14, GJA1
17sb 20358044 5911.3GJA1, BIRC5, BMP2, BSG, STAT6
18pd 98,0594410.3MMP14, BMP2, BIRC5, GJA1, STAT6
19actinomycin d4410.3BMP2, MMP14, PECAM1, STAT6, BIRC5
20phosphoinositide4410.3BSG, EPHA2, BIRC5, MMP14, PECAM1
21phosphotyrosine4410.3EPHA2, GJA1, PECAM1, MMP14
225fluorouracil4410.3YBX1, NME1, BIRC5, PCNA, TSC22D1
23genistein44 28 59 2 11 2415.2BMP2, GJA1, MMP14, PCNA, BIRC5
24heparin44 28 11 2413.2BSG, BMP2, VCAN, PECAM1
25agar4410.2BIRC5, PECAM1, GJA1, MMP14, YBX1, EPHA2
26matrigel4410.2BSG, BMP2, NES, MMP14, GJA1, NME1
27cisplatin44 49 59 1113.2YBX1, PCNA, YY1, NME1, GJA1, BIRC5
28lactate4410.2NME1, MMP14, PCNA, BSG, BMP2, BIRC5
29paraffin4410.2MMP14, NES, PCNA, GJA1, NME1, BIRC5
30nitric oxide44 11 2412.2PECAM1, YY1, BIRC5, NME1, GJA1, NES
31serine4410.2NME1, GJA1, PECAM1, STAT6, YBX1, BMP2
32cholesterol44 28 11 2413.2PECAM1, BIRC5, BSG, BMP2, MMP14, YY1
33steroid4410.1STAT6, YBX1, BIRC5, YY1, BMP2, NME1
34dexamethasone44 49 28 1113.1NME1, STAT6, BMP2, PCNA, MMP14, GJA1
35atp44 2811.1YY1, BIRC5, NME1, YBX1, PECAM1, STAT6
36norcantharidin4410.1PCNA, BIRC5
37adpribose4410.1PCNA, BIRC5, YY1
38threonine4410.1PECAM1, BIRC5, MMP14, YBX1, BSG, BMP2
39retinoic acid44 2411.1BMP2, STAT6, PCNA, GJA1, BIRC5, PECAM1
40thymidine44 2411.0BMP2, PCNA, MMP14, NME1, BIRC5, YY1
41progesterone44 59 28 11 2414.0GJA1, NES, MMP14, PCNA, BIRC5, BMP2
42alanine4410.0BIRC5, BMP2, GJA1, MMP14, PCNA, NME1
43lipid4410.0BMP2, PECAM1, BIRC5, GJA1, MMP14, NES
44oxygen44 2410.9PECAM1, GJA1, MMP14, NES, BMP2, BIRC5
45paclitaxel44 49 1111.8GJA1, YBX1, BIRC5
46cysteine449.8GJA1, PCNA, BMP2, NME1, PECAM1, MMP14
47calcium44 49 11 2412.8NME1, YY1, GJA1, PECAM1, CLDN5, STAT6
48tyrosine449.8PECAM1, EPHA2, NES, STAT6, BSG, MMP14
49oligonucleotide449.8STAT6, YBX1, MMP14, NME1, BIRC5, VCAN
50vegf449.6BMP2, NES, PCNA, EPHA2, YBX1, MMP14

GO Terms for genes affiliated with Brain Glioma

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16Gene Ontology
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Biological processes related to Brain Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell recognitionGO:00803710.3PECAM1, VCAN
2osteoblast differentiationGO:00164910.1GJA1, BMP2, EPHA2
3heart developmentGO:00750710.0PCNA, BMP2, VCAN, GJA1
4mammary gland epithelial cell proliferationGO:03359810.0EPHA2, STAT6

Molecular functions related to Brain Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament bindingGO:01921510.0NME1, NES
2identical protein bindingGO:0428029.9PCNA, CLDN5, NME1, BIRC5, STAT6
3protein bindingGO:0055158.5TSC22D1, BMP2, BSG, STAT6, METTL9, OCLN

Products for genes affiliated with Brain Glioma

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Sources for Brain Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet