MCID: BRN032
MIFTS: 50

Brain Glioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Brain Glioma

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MalaCards: Brain Glioma, also known as glial tumor of brain, is related to malignant glioma and brain stem glioma. An important gene associated with Brain Glioma is GJA1 (gap junction protein, alpha 1, 43kDa), and among its related pathways are Cell adhesion Endothelial cell contacts by junctional mechanisms and Leukocyte transendothelial migration. The compounds resveratrol and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and bone, and related mouse phenotypes are limbs/digits/tail and respiratory system.

Aliases & Classifications for Brain Glioma

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8Disease Ontology, 22GTR, 10DISEASES, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain glioma 8 22 10
glial tumor of brain 60


External Ids:

Disease Ontology8 DOID:0060108

Related Diseases for Brain Glioma

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17GeneCards, 18GeneDecks
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Diseases related to Brain Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1malignant glioma30.7BSG, NES, PCNA, MMP14, GJA1, BIRC5
2brain stem glioma30.6BSG
3brain cancer30.4NES, MMP14, GJA1, BIRC5, VCAN, PECAM1
4meningioma29.9PCNA
5stomach cancer29.9BIRC5, NME1, MMP14, PCNA, BMP2
6cerebritis10.1
7neuroblastoma10.0NME1
8tuberous sclerosis10.0NES
9peritonitis10.0PECAM1
10inflammatory bowel disease10.0OCLN
11fibrosarcoma10.0MMP14, NES
12endometriosis10.0BSG, MMP14
13anaplastic large cell lymphoma10.0BSG
14vascular disease10.0GJA1, PCNA
15gastrointestinal stromal tumor10.0NES, PCNA
16pituitary tumors10.0BMP2
17endometrial carcinoma10.0NME1, MMP14, PCNA
18bladder carcinoma10.0BSG, PCNA
19pituitary adenoma10.0PCNA, NES
20smooth muscle tumor10.0NME1, PCNA
21myocardial infarction10.0PECAM1, GJA1
22cervical intraepithelial neoplasia10.0YY1, BIRC5, NME1
23papilloma10.0GJA1, PCNA
24cervical cancer10.0MMP14, NME1, BIRC5, YY1
25rhabdomyosarcoma10.0NES, MMP14, GJA1
26cervical squamous cell carcinoma10.0MMP14
27leiomyoma10.0BSG, NES, PCNA, GJA1
28uterine fibroid10.0BSG, PCNA, GJA1
29lung benign neoplasm10.0BMP2, EPHA2, GJA1, PECAM1
30laryngeal benign neoplasm10.0BSG, PCNA, MMP14, NME1
31laryngeal squamous cell carcinoma10.0BSG, PCNA, NME1, BIRC5
32medulloblastoma10.0BMP2, NES, VCAN
33adenoma10.0NES, PCNA, GJA1, NME1, BIRC5
34sarcoma10.0BMP2, NES, EPHA2, YBX1, PECAM1
35brain ischemia10.0NES
36esophageal cancer10.0PCNA, MMP14, NME1
37non-small cell lung carcinoma10.0BMP2, PCNA, NME1, BIRC5
38ischemia10.0PECAM1, GJA1, MMP14, NES, BSG
39nasopharynx carcinoma10.0NME1, GJA1, PCNA
40arthritis10.0BMP2, STAT6, MMP14, PECAM1
41hypertrophy of breast10.0YY1, GJA1, NES, STAT6, BMP2
42anaplastic astrocytoma10.0PCNA, NES, BSG
43transitional cell carcinoma10.0BSG, PCNA, MMP14, NME1, BIRC5
44myeloma10.0BIRC5, BMP2
45colorectal cancer10.0PCNA, EPHA2, MMP14, NME1, BIRC5
46pancreatic cancer10.0NES, MMP14, BIRC5
47retinoblastoma10.0YY1, BIRC5, NME1, PCNA, BMP2
48rheumatoid arthritis10.0BMP2, BSG, STAT6, MMP14, PECAM1
49cadasil10.0PECAM1, GJA1, NES, BSG
50astrocytoma10.0BSG, NES, PCNA, MMP14, GJA1, TSC22D1

Graphical network of the top 20 diseases related to Brain Glioma:



Diseases related to brain glioma

Clinical Features for Brain Glioma

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Drugs & Therapeutics for Brain Glioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Brain Glioma

Drug clinical trials:

Search ClinicalTrials for Brain Glioma

Search NIH Clinical Center for Brain Glioma

Search CenterWatch for Brain Glioma

Genetic Tests for Brain Glioma

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22GTR
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Genetic tests related to Brain Glioma:

id Genetic test Affiliating Genes
1 Glioma of Brain22

Anatomical Context for Brain Glioma

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32MalaCards
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MalaCards organs/tissues related to Brain Glioma:

32
Brain, Endothelial, Bone, Fetal brain, Testes, T cells, Monocytes, Cervix, Spinal cord, Pons

Animal Models for Brain Glioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Brain Glioma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.4VCAN
2MP:000538810.0STAT6, YBX1, MMP14, GJA1, YY1, PECAM1
3MP:000539010.0BMP2, OCLN, EPHA2, MMP14, GJA1, VCAN
4MP:00028739.7EPHA2, MMP14, GJA1, BIRC5, VCAN, YY1
5MP:00053809.6RFX4, BMP2, NES, MYBBP1A, EPHA2, YBX1
6MP:00053769.5BMP2, STAT6, OCLN, EPHA2, YBX1, MMP14
7MP:00053859.5BMP2, EPHA2, CLDN5, YBX1, MMP14, GJA1
8MP:00053789.5BMP2, BSG, STAT6, NES, OCLN, PCNA
9MP:00053849.4BMP2, STAT6, NES, PCNA, YBX1, MMP14
10MP:00036319.4BMP2, NES, OCLN, EPHA2, CLDN5, YBX1
11MP:00053979.3STAT6, PCNA, YBX1, GJA1, NME1, BIRC5
12MP:00107689.1PCNA, MYBBP1A, NES, STAT6, BSG, BMP2

Publications for Brain Glioma

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50PubMed
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Articles related to Brain Glioma:

(show top 50)    (show all 284)
idTitleAuthorsYear
1
Molecular and metabolic pattern classification for detection of brain glioma progression. (24321226)
2014
2
Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase. (24399197)
2014
3
Differences of SiHa (human cancer of cervix) and BMG-1 (brain glioma) cell lines as 2D and 3D cultures. (23881600)
2014
4
CCL2-expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo. (22319587)
2012
5
Intracranial syphilitic gumma mimicking a brain stem glioma. (22723064)
2012
6
Nestin expression in brain tumors: its utility for pathological diagnosis and correlation with the prognosis of high-grade gliomas. (22350668)
2012
7
Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study. (21606416)
2011
8
Single nucleotide polymorphisms in IL-4Ra, IL-13 and STAT6 genes occurs in brain glioma. (21196282)
2011
9
A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03. (21377994)
2011
10
Evaluation of a fibrin-binding gadolinium chelate peptide tetramer in a brain glioma model. (21150792)
2011
11
Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature. (21867556)
2011
12
Honokiol crosses BBB and BCSFB, and inhibits brain tumor growth in rat 9L intracerebral gliosarcoma model and human U251 xenograft glioma model. (21559510)
2011
13
Development of transferrin functionalized poly(ethylene glycol)/poly(lactic acid) amphiphilic block copolymeric micelles as a potential delivery system targeting brain glioma. (20535631)
2010
14
Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain. (19833108)
2010
15
Glioma cell populations grouped by different cell type markers drive brain tumor growth. (20460538)
2010
16
The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma. (21060663)
2010
17
Diffuse brain stem glioma. (20212241)
2010
18
Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity. (20008733)
2009
19
In vivo micro-CT imaging of rat brain glioma: a comparison with 3T MRI and histology. (19379792)
2009
20
Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas. (18607344)
2008
21
Brain surface spindle cell glioma in a patient with medically intractable partial epilepsy: a variant of monomorphous angiocentric glioma? (18179412)
2008
22
Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas. (18324354)
2008
23
Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group Study. (18824712)
2008
24
11C-acetate PET in the evaluation of brain glioma: comparison with 11C-methionine and 18F-FDG-PET. (18543041)
2008
25
Mutations of p53 gene in 41 cases of human brain gliomas]. (18184456)
2008
26
Use of interferon-alpha-induced dendritic cells in the therapy of patients with malignant brain gliomas. (18214316)
2007
27
Rough set feature selection and rule induction for prediction of malignancy degree in brain glioma. (16893588)
2006
28
Glioma cells under hypoxic conditions block the brain microvascular endothelial cell death induced by serum starvation. (16042757)
2005
29
Biopsy of brain stem glioma using motor-evoked potential mapping by direct peduncular stimulation and individual adjuvant therapy. Case report. (15699622)
2005
30
Diagnosis of brain gliomas in stereotactic biopsy assisted by optical neuro-navigation system]. (15049161)
2004
31
Monofocal acute large demyelinating lesion mimicking brain glioma. (15727241)
2004
32
Assessment of vascular reactivity in rat brain glioma by measuring regional blood volume during graded hypoxic hypoxia. (15188003)
2004
33
Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 signaling in brain endothelial cells. Specific role for glypican-1 in glioma angiogenesis. (12591930)
2003
34
Implantable drug-releasing biodegradable microspheres for local treatment of brain glioma. (14531561)
2003
35
Rapid induction of long-lasting drug efflux activity in brain vascular endothelial cells but not malignant glioma following irradiation. (12025885)
2002
36
Fuzzy rules to predict degree of malignancy in brain glioma. (12043794)
2002
37
Brain glioma and human leukocyte antigens (HLA)--is there an association. (11519856)
2001
38
The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene in brain tissues and gliomas. (11050470)
2000
39
Expression of emmprin (CD147), a cell surface inducer of matrix metalloproteinases, in normal human brain and gliomas. (10962435)
2000
40
Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member. (10801887)
2000
41
Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix metalloproteinases and activated gelatinase A in co-cultures with brain-derived fibroblasts. (10936678)
2000
42
Diffuse brain stem glioma. A review of stereotactic biopsies. (10392494)
1999
43
Expression of annexin II in glioma cell lines and in brain tumor biopsies. (9540053)
1998
44
BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines. (8625302)
1996
45
Leptomyxid amebic meningoencephalitis mimicking brain stem glioma. (7611076)
1995
46
T1 snapshot FLASH measurement of rat brain glioma: kinetics of the tumor-enhancing contrast agent manganese (III) tetraphenylporphine sulfonate. (1461108)
1992
47
Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma. (1902547)
1991
48
A case of dyschondroplasia associated with brain stem glioma: diagnosis by stereotactic biopsy. (2234348)
1990
49
Antibody guided irradiation of brain glioma by arterial infusion of radioactive monoclonal antibody against epidermal growth factor receptor and blood group A antigen. (2986752)
1985
50
Clinicopathologic conference. Baptist Memorial Hospital. Brain stem glioma in children. (4313782)
1970

Genetic Variations for Brain Glioma

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Expression for genes affiliated with Brain Glioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Glioma

Search GEO for disease gene expression data for Brain Glioma.

Pathways for genes affiliated with Brain Glioma

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12EMD Millipore, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Brain Glioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2GJA1, CLDN5, OCLN
210.1PECAM1, CLDN5, OCLN
310.1MMP14, PCNA, BMP2
410.0OCLN, CLDN5, VCAN, PECAM1

Compounds for genes affiliated with Brain Glioma

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Brain Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1resveratrol44 59 11 2413.7BMP2
2cycloheximide4410.7TSC22D1, GJA1
3etoposide44 49 59 1113.7YBX1, GJA1
4nimbolide4410.6PCNA, BIRC5
5polycaprolactone4410.5PECAM1, BMP2
6dbpa4410.5YBX1, PCNA
7alginate4410.5VCAN, MMP14, BMP2
8prinomastat4410.5MMP14, BSG
9glucose4410.5BSG, BIRC5, VCAN, YY1
10p0024410.5MMP14, NME1, BIRC5, PECAM1
11cytochalasin b4410.4BSG, MMP14, BIRC5
12bromodeoxyuridine4410.4GJA1, NES, PCNA, MMP14
13lipofectamine4410.4BIRC5, GJA1
14dmso4410.4NME1, GJA1, NES, BIRC5
15ribonucleic acid4410.4MMP14, GJA1, NME1, PECAM1, BMP2
16calcitriol44 59 11 2413.4NME1, BMP2, MMP14, GJA1
17sb 20358044 5911.3GJA1, BIRC5, BMP2, BSG, STAT6
18pd 98,0594410.3MMP14, BMP2, BIRC5, GJA1, STAT6
19actinomycin d4410.3BMP2, MMP14, PECAM1, STAT6, BIRC5
20phosphoinositide4410.3BSG, EPHA2, BIRC5, MMP14, PECAM1
21phosphotyrosine4410.3EPHA2, GJA1, PECAM1, MMP14
225fluorouracil4410.3YBX1, NME1, BIRC5, PCNA, TSC22D1
23genistein44 28 59 2 11 2415.2BMP2, GJA1, MMP14, PCNA, BIRC5
24heparin44 28 11 2413.2BSG, BMP2, VCAN, PECAM1
25agar4410.2BIRC5, PECAM1, GJA1, MMP14, YBX1, EPHA2
26matrigel4410.2BSG, BMP2, NES, MMP14, GJA1, NME1
27cisplatin44 49 59 1113.2YBX1, PCNA, YY1, NME1, GJA1, BIRC5
28lactate4410.2NME1, MMP14, PCNA, BSG, BMP2, BIRC5
29paraffin4410.2MMP14, NES, PCNA, GJA1, NME1, BIRC5
30nitric oxide44 11 2412.2PECAM1, YY1, BIRC5, NME1, GJA1, NES
31serine4410.2NME1, GJA1, PECAM1, STAT6, YBX1, BMP2
32cholesterol44 28 11 2413.2PECAM1, BIRC5, BSG, BMP2, MMP14, YY1
33steroid4410.1STAT6, YBX1, BIRC5, YY1, BMP2, NME1
34dexamethasone44 49 28 1113.1NME1, STAT6, BMP2, PCNA, MMP14, GJA1
35atp44 2811.1YY1, BIRC5, NME1, YBX1, PECAM1, STAT6
36norcantharidin4410.1PCNA, BIRC5
37adpribose4410.1PCNA, BIRC5, YY1
38threonine4410.1PECAM1, BIRC5, MMP14, YBX1, BSG, BMP2
39retinoic acid44 2411.1BMP2, STAT6, PCNA, GJA1, BIRC5, PECAM1
40thymidine44 2411.0BMP2, PCNA, MMP14, NME1, BIRC5, YY1
41progesterone44 59 28 11 2414.0GJA1, NES, MMP14, PCNA, BIRC5, BMP2
42alanine4410.0BIRC5, BMP2, GJA1, MMP14, PCNA, NME1
43lipid4410.0BMP2, PECAM1, BIRC5, GJA1, MMP14, NES
44oxygen44 2410.9PECAM1, GJA1, MMP14, NES, BMP2, BIRC5
45paclitaxel44 49 1111.8GJA1, YBX1, BIRC5
46cysteine449.8GJA1, PCNA, BMP2, NME1, PECAM1, MMP14
47calcium44 49 11 2412.8NME1, YY1, GJA1, PECAM1, CLDN5, STAT6
48tyrosine449.8PECAM1, EPHA2, NES, STAT6, BSG, MMP14
49oligonucleotide449.8STAT6, YBX1, MMP14, NME1, BIRC5, VCAN
50vegf449.6BMP2, NES, PCNA, EPHA2, YBX1, MMP14

GO Terms for genes affiliated with Brain Glioma

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16Gene Ontology
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Biological processes related to Brain Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell recognitionGO:00803710.3PECAM1, VCAN
2osteoblast differentiationGO:00164910.1BMP2, EPHA2, GJA1
3heart developmentGO:00750710.0VCAN, GJA1, PCNA, BMP2
4mammary gland epithelial cell proliferationGO:03359810.0EPHA2, STAT6

Molecular functions related to Brain Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament bindingGO:01921510.0NME1, NES
2identical protein bindingGO:0428029.9PCNA, CLDN5, NME1, BIRC5, STAT6
3protein bindingGO:0055158.5TSC22D1, BMP2, BSG, STAT6, METTL9, OCLN

Products for genes affiliated with Brain Glioma

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Sources for Brain Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet