Brain Injury malady

Wikipedia: A brain injury is any injury occurring in the brain of a living organism. Brain injuries can be...⁴⁴ more...

MalaCards: Brain Injury is related to traumatic brain injury and head injury. An important gene associated with Brain Injury is SLC1A6 (solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6), and among its related pathways are Rho Family GTPases and Pathogenesis of ALS. The compounds catecholamine and acth have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and monocytes, and related mouse phenotypes are hematopoietic system and respiratory system.

NINDS: Traumatic brain injury (TBI), a form of³¹

brain injury 31

Diseases related to brain injury by text searches and GeneDecks gene sharing:

(show top 50)    (show all 970)

id	Related Disease	Score	Top Affiliating Genes
1	traumatic brain injury	51.0	RETN, SERPINC1, SERPINI1, VEGFA, VCAN, BMP2
2	head injury	34.3	SELP, BECN1, BDNF, CKB, CHRM1, S100B
3	hypopituitarism	32.5	LEP, INS, IL6, IGF1, GH1, GHRH
4	cerebral hemorrhage	30.7	MTHFR, S100B, INS, IL1B, IL1RN, IL6
5	seizures	30.7	CNR1, SERPINI1, VEGFA, RABEP2, PARP1, BDNF
6	neurodegenerative disease	30.2	NCAM1, CNR1, SERPINI1, RAC1, PARP1, BDNF
7	cerebral amyloid angiopathy	30.0	MME, MMP9, IL1A, IL6, AQP4, APOE
8	brain edema	29.9	VEGFA, PARP1, BDKRB2, MMP9, MIP, IL1B
9	cerebral artery occlusion	29.7	SELP, SERPINE1, VEGFA, PARP1, BDNF, MPO
10	cerebral hypoxia	29.6	BMP7, FOS, APP, CASP3, CREB1, PLAT
11	neuronitis	29.6	NDFIP1, NCAM1, RETN, CNR1, VWF, VSNL1
12	tauopathy	29.4	SERPINI1, CDKN3, GRN, APP, MAPT, MAPK8
13	hypoglycemia	29.3	VEGFA, BDNF, CKB, LEP, CHKB, P2RX4
14	growth hormone deficiency	29.3	RETN, SERPINE1, BGLAP, LEP, LEPR, XDH
15	parkinson's disease	29.3	CNR1, PARP1, BDNF, CHKB, UCHL1, MT3
16	chorioamnionitis	29.2	SERPINC1, BMP6, MPO, MMP3, MMP9, IL10
17	schizophrenia	29.0	BMP6, MTHFR, IL1B, IL1RN, ANKK1, MAOA
18	aphasia	28.9	GRN, APOE, APP, MAPT, SNCA, PLAT
19	periventricular leukomalacia	28.7	VEGFA, IL18, IL1B, IL1R1, IL6, APP
20	leukomalacia	28.7	VEGFA, IL18, IL1B, IL1R1, IL6, APP
21	epilepsy syndrome	28.4	CNR1, SERPINI1, BDNF, MT3, CDKN3, MIP
22	septic shock	28.4	SERPINC1, SERPINE1, XDH, CFP, IL10, IL1A
23	dementia	28.3	NCAM1, VWF, SELP, SERPINC1, SERPINI1, SERPINE1
24	transient cerebral ischemia	28.2	BCL2, XIAP, JUN, FOS, GSR, GRIN2A
25	cerebritis	27.1	NDFIP1, NCAM1, CNR1, VWF, SELP, SERPINC1
26	neutropenia	27.1	BCL2, S100B, MPO, IL10, IL1A, IL1B
27	alzheimer's disease	27.1	NCAM1, CNR1, VSNL1, SELP, SERPINC1, SERPINI1
28	ischemia	26.8	NDFIP1, NCAM1, RETN, CNR1, VWF, SELP
29	cerebrovascular disease	26.8	RETN, VWF, SELP, SERPINC1, SERPINE1, VEGFA
30	sepsis	26.3	RETN, SELP, SERPINC1, SERPINE1, S100A8, XDH
31	cerebral infarction	25.7	VWF, SELP, SERPINC1, SERPINE1, VEGFA, BMP7
32	ataxia	25.5	VWF, VSNL1, SERPINI1, SERPINE1, BECN1, PARP1
33	pneumonia	25.5	SERPINC1, SERPINE1, VEGFA, BMP6, RAC1, BGLAP
34	hypoxia	24.6	VWF, SELP, SERPINE1, VEGFA, BMP2, BMP6
35	status epilepticus	14.8	CNR1, SERPINI1, BDNF, JUN, FOS, GRIN2B
36	pick's disease	14.6	BDNF, CKB, CHKB, UCHL1, GRN, APOE
37	ganglioneuroblastoma	14.6	S100B, MBP, ENO2, HTR1A, TP53, CRH
38	temporal lobe epilepsy	14.6	BDNF, GRIK1, GRIK2, GRIN2B, AQP4, HTR1A
39	frontotemporal dementia	14.5	SERPINI1, BDNF, BACE1, JUN, CDKN3, GRN
40	hydrocephalus	14.5	BDNF, MTHFR, MSI2, INS, IL10, IL1R1
41	spinocerebellar ataxia type 3	14.5	BECN1, S100B, APOE, ENO2, HTR1A, HTR3A
42	alcohol abuse	14.5	CLEC3B, MMP9, GSR, ANKK1, HTR2A, DRD2
43	restless legs syndrome	14.5	MAOA, HTR3A, CACNA1A, DRD2, SNCA, NOS1
44	diabetes, type 2	14.4	MMP3, INS, IL18, ALB, NOS3, COL18A1
45	tetralogy of fallot	14.4	MTHFR, S100A1, MMP3, MMP9, IL6, IL8
46	myopia 6	14.4	VEGFA, VCAN, BDNF, CHRM1, CFP, MMP3
47	hirschsprung's disease	14.4	NCAM1, BCL2, UCHL1, S100B, AXIN2, MME
48	moyamoya disease	14.4	RETN, SERPINC1, MMP3, MMP9, IL1B, CCL2
49	hereditary cerebral hemorrhage with amyloidosis	14.4	IL6, APP, RPS27A, AGRN, GFAP, SYP
50	hepatic encephalopathy	14.4	S100B, IL18, IL6, AQP4, MAOA, F2

Approved drugs:

Drug clinical trials:

Cell-based therapeutics:

MalaCards organs/tissues related to brain injury:

²²

MGI Mouse Phenotypes related to brain injury:

²⁵ (show all 30)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	11.2	NDFIP1, BDKRB2, BCL2, KCNN4, BBC3, UCHL1
2	respiratory system phenotype	MP:0005388	11.0	NDFIP1, SELP, BDNF, SCN8A, LEPR, CHRM1
3	craniofacial phenotype	MP:0005382	10.9	BDNF, AXIN2, INHBA, IL17A, MAPK8, MAP3K11
4	hearing/vestibular/ear phenotype	MP:0005377	10.7	BMP2, BMP7, PARP1, BDNF, BCL2, SCN8A
5	embryogenesis phenotype	MP:0005380	10.2	SERPINC1, RAC1, BECN1, PARP1, AXIN2, CDH2
6	endocrine/exocrine gland phenotype	MP:0005379	10.2	NDFIP1, BDKRB2, KCNN4, XDH, AXIN2, AQP7
7	liver/biliary system phenotype	MP:0005370	10.2	NDFIP1, RETN, SERPINC1, VEGFA, CEBPA, INS
8	taste/olfaction phenotype	MP:0005394	9.9	CNR1, BDNF, ENO2, MAPT, MAPK1, CASP3
9	nervous system phenotype	MP:0003631	9.8	NDFIP1, CNR1, VWF, SELP, SERPINC1, VCAN
10	no phenotypic analysis	MP:0003012	9.7	CNR1, VEGFA, PARP1, BDNF, KCNN1, SCN8A
11	other phenotype	MP:0005395	9.6	CNR1, KDR, LEPR, BACE1, MME, APOE
12	pigmentation phenotype	MP:0001186	9.5	SERPINC1, BMP7, RAC1, BCL2, LEP, GRN
13	limbs/digits/tail phenotype	MP:0005371	9.4	NDFIP1, VEGFA, VCAN, BMP2, BMP7, RAC1
14	normal phenotype	MP:0002873	9.3	VEGFA, VCAN, BMP2, BMP7, BDKRB2, BDNF
15	digestive/alimentary phenotype	MP:0005381	9.3	VWF, VEGFA, BMP2, BMP7, BDKRB2, BDNF
16	reproductive system phenotype	MP:0005389	9.1	VEGFA, BMP2, BMP7, BECN1, BDKRB2, SCN8A
17	skeleton phenotype	MP:0005390	9.0	CNR1, VEGFA, VCAN, BMP2, BMP6, BMP7
18	renal/urinary system phenotype	MP:0005367	8.7	SELP, BMP7, BDKRB2, BCL2, LEPR, UCHL1
19	behavior/neurological phenotype	MP:0005386	8.5	NCAM1, CNR1, SELP, SERPINI1, BDKRB2, BDNF
20	homeostasis/metabolism phenotype	MP:0005376	8.4	NDFIP1, RETN, CNR1, VWF, SELP, SERPINC1
21	immune system phenotype	MP:0005387	8.4	NDFIP1, VWF, SELP, BDKRB2, KDR, KCNN4
22	adipose tissue phenotype	MP:0005375	8.4	RETN, CNR1, SERPINE1, BDKRB2, BCL2, LEP
23	growth/size phenotype	MP:0005378	8.4	NDFIP1, CNR1, SELP, SERPINE1, BMP2, BMP6
24	muscle phenotype	MP:0005369	8.2	VEGFA, RAC1, KDR, BCL2, KCNN4, SCN8A
25	integument phenotype	MP:0010771	8.0	NDFIP1, CNR1, SELP, RAC1, BECN1, PARP1
26	mortality/aging	MP:0010768	8.0	NDFIP1, NCAM1, CNR1, VWF, SELP, SERPINC1
27	vision/eye phenotype	MP:0005391	7.7	NCAM1, SELP, SERPINC1, VEGFA, BMP7, BDNF
28	cardiovascular system phenotype	MP:0005385	6.9	VWF, SELP, SERPINC1, SERPINE1, VEGFA, BMP2
29	cellular phenotype	MP:0005384	6.6	NDFIP1, NCAM1, CNR1, VWF, SELP, VEGFA
30	tumorigenesis	MP:0002006	6.1	SERPINE1, BECN1, BCL2, LEP, LEPR, CEBPA

Articles related to brain injury:

(show top 50)    (show all 394)

id	Title	Authors	Year	Affiliating Genes
1	Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. (21706018)	Fancy S.P.... Rowitch D.H.	2011	AXIN2
2	Genetic analysis of the role of tumor necrosis factor receptors in functional outcome after traumatic brain injury in mice. (20205514)	Yang J.... Whalen M.J.	2010	FAS
3	Widespread cortical expression of MANF by AAV serotyp e 7: localization and protection against ischemic brain injury. (20685313)	Airavaara M.... Harvey B.K.	2010	MANF
4	Substance P antagonists as a therapeutic approach to improving outcome following traumatic brain injury. (20129499)	Vink R.... van den Heuvel C.	2010	TACR1
5	Leukocyte recruitment and ischemic brain injury. (19579016)	Yilmaz G.... Granger D.N.	2010	CD226
6	Impaired expression of neuroprotective molecules in t he HIF-1alpha pathway following traumatic brain injury in aged mice. (19203226)	Anderson J.... Berman N.E.	2009	HMOX1, EPO
7	Spillway-induced salmon head injury triggers the generation of brain alphaII-spectrin breakdown product biomarkers similar to mammalian traumatic brain injury. (19214235)	Miracle A.... Wang K.K.	2009	SPTAN1
8	Incomplete deficiency of hypothalamic hormones in hyp othalamic hypopituitarism associated with an old traumatic brain injury. (19638713)	Saito T.... Ishikawa S.E.	2009	INS
9	Serum biochemical markers of brain injury. (19200027)	Korfias S.... Sakas D.E.	2009	ENO2
10	Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligo dendrocyte transcription factor 2 is associated with their fate choice. (19473238)	Zhao J.W.... Watts C.	2009	CSPG4, OLIG2
11	Brain injury does not alter the intrinsic differentiation potential of adult neuroblasts. (19386903)	Liu F.... Yang Z.	2009	SP8
12	The apolipoprotein E epsilon4 allele and outcome in s evere traumatic brain injury treated by an intracranial pressure-targeted thera py. (19747047)	Olivecrona M.... Koskinen L.O.	2009	APOE
13	Oxidative stress in subarachnoid haemorrhage: significance in acute brain injury and vasospasm. (18456995)	Ayer R.E.... Zhang J.H.	2008	NOS2, XDH
14	Leptin receptors and beta2-adrenergic receptor mRNA expression in brain injury-related heterotopic ossification. (18702008)	Chauveau C.... Broux O.	2008	ADRB2, LEPR
15	Diagnosis and treatment of adult growth hormone deficiency (aGHD) resulting from brain injury--role of aGHD (19110756)	Arita K.... Kurisu K.	2008	IGF1
16	Glucose control after severe brain injury. (18301088)	Oddo M.... ChiolAcro R.L.	2008	INS
17	17alpha-Estradiol is neuroprotective in male and fema le rats in a model of early brain injury. (17997403)	McClean J.... NuA+ez J.L.	2008	ESR1
18	Gender and estrogen manipulation do not affect trauma tic brain injury in mice. (17263684)	Bruce-Keller A.J.... Scheff S.W.	2007	IL6
19	Diffuse alterations in synaptic protein expression following focal traumatic brain injury in the immature rat. (17457592)	Gobbel G.T.... Adelson P.D.	2007	SYP
20	Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism? (17287237)	Han S.D.... Bondi M.W.	2007	APOE
21	Carbamylated erythropoietin reduces radiosurgically-induced brain injury. (16953562)	Erbayraktar S.... Brines M.	2006	EPO
22	Hypopituitarism in childhood and adolescence following traumatic brain injury: the case for prospective endocrine investigation. (17062881)	Acerini C.L.... Savage M.O.	2006	GH1
23	Novel differential neuroproteomics analysis of traumatic brain injury in rats. (16801361)	Kobeissy F.H.... Wang K.K.	2006	DPYSL2
24	Serum biomarkers after traumatic and hypoxemic brain injuries: insight into the biochemical response of the pediatric brain to inflicted brain injury. (16943655)	Berger R.P.... Kochanek P.M.	2006	ENO2, MBP
25	High thyroglobulin (Tg) concentrations in fatal traumatic brain injuries. (16936513)	Dressler J.... Mueller E.	2006	TG
26	The expression of COX-1 and COX-2 following brain injuries (16259374)	Guo X.R.... Ma Y.L.	2005	COX5A
27	IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury. (16217062)	Hadjigeorgiou G.M.... Karantanas A.	2005	IL1B, IL1RN
28	Cerebral amyloid angiopathy in traumatic brain injury: association with apolipoprotein E genotype. (15654038)	Leclercq P.D.... Gentleman S.M.	2005	APOE
29	Ubiquitin immunoreactivity in cerebrospinal fluid aft er traumatic brain injury: clinical and experimental findings. (16003067)	Majetschak M.... Proctor K.G.	2005	RPS27A
30	Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. (15858058)	Nicole O.... Traynelis S.F.	2005	F2R
31	Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma. (15379997)	Mauler F.... Urbahns K.	2004	KCNN4, KCNN1
32	Occurrence of pituitary dysfunction following traumatic brain injury. (15253797)	Bondanelli M.... degli Uberti E.C.	2004	PRL
33	Traumatic brain injury and subarachnoid haemorrhage a re conditions at high risk for hypopituitarism: screening study at 3 months aft er the brain injury. (15355447)	Aimaretti G.... Ghigo E.	2004	IGF1
34	Ex vivo gene therapy using targeted engraftment of NG F-expressing human NT2N neurons attenuates cognitive deficits following traumat ic brain injury in mice. (15684764)	Longhi L.... McIntosh T.K.	2004	NGF
35	Correlation between transcranial interleukin-6 gradient and outcome in patients with acute brain injury. (12627008)	Minambres E.... Leyva-Cobian F.	2003	IL6
36	Detrimental role of bradykinin B2 receptor in a murine model of diffuse brain injury. (14577862)	Hellal F.... Marchand-Verrecchia C.	2003	BDKRB2
37	Clinical analysis of the syndrome of inappropriate an tidiuretic hormone secretion after brain injury. (12749792)	Cai J.N.... Yi J.	2003	ALB
38	Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children. (11826241)	Berger R.P.... Kochanek P.M.	2002	S100B, ENO2
39	Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival. (11399754)	Hama T.... Nara K.	2001	TMEM158
40	Accumulation of non-erythroid alpha II-spectrin and calpain-cleaved alpha II-spectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats. (11579138)	Pike B.R.... Hayes R.L.	2001	SPTAN1
41	The duality of the inflammatory response to traumatic brain injury. (11831551)	Lenzlinger P.M.... McIntosh T.K.	2001	BMP6
42	Markers for cell-mediated immune response are elevated in cerebrospinal fluid and serum after severe traumatic brain injury in humans. (11393251)	Lenzlinger P.M.... Kossmann T.	2001	IL2RA
43	Expression of the plasminogen activator system and the inhibitors PAI-1 and PAI-2 in posttraumatic lesions of the CNS and brain injuries following dramatic circulatory arrests: an immunohistochemical study. (10674268)	Dietzmann K.... Kirches E.	2000	CLEC3B
44	Beneficial effects of n-acetylcysteine on ischaemic brain injury. (10903958)	Cuzzocrea S.... Caputi A.P.	2000	MPO, EPRS
45	The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models. (10867209)	Horsburgh K.... Nicoll J.A.	2000	APOE
46	Focal brain injury, FGF-2 and the adverse effects of excessive motor demand on cortical and nigral degeneration: marked protection by delayed intermittent exposure to halothane. (11101209)	Gotts J.E.... Schallert T.	2000	NUDT6
47	CCAAT-enhancer binding protein alpha is expressed in activated microglial cells after brain injury. (9795105)	Walton M.... Dragunow M.	1998	CEBPA
48	CSF and serum brain-specific creatine kinase isoenzyme (CK-BB), neuron-specific enolase (NSE) and neural cell adhesion molecule (NCAM) as prognostic markers for hypoxic brain injury after cardiac arrest in man. (8509798)	Karkela J.... Kaukinen S.	1993	ENO2, NCAM1, CKB
49	Is c-Jun involved in nerve cell death following statu s epilepticus and hypoxic-ischaemic brain injury? (8326831)	Dragunow M.... Gluckman P.	1993	FOS, JUN, DRD2
50	Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation. (8245962)	Saito K.... Heyes M.P.	1993	KYNU, KMO

Genes related to brain injury according to GeneCards:

(show top 50)    (show all 261)

id	Symbol	Description	Score	GeneCards Section Context
1	SLC1A6	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	11.1	Summaries
2	SLC1A7	solute carrier family 1 (glutamate transporter), member 7	11.1	Summaries
3	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	11.1	Summaries, Publications
4	SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	11.1	Summaries
5	EPO	erythropoietin	11.1	Publications, Summaries
6	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11.1	Publications, Summaries
7	TMEM158	transmembrane protein 158 (gene/pseudogene)	11.1	Functions, Aliases & Descriptions, Publications
8	CYSLTR1	cysteinyl leukotriene receptor 1	11.0	Publications
9	NOS1	nitric oxide synthase 1 (neuronal)	11.0	Publications
10	PARP1	poly (ADP-ribose) polymerase 1	11.0	Publications
11	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
12	APP	amyloid beta (A4) precursor protein	11.0	Publications
13	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
14	SLC24A2	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	11.0	Summaries
15	MIR107	microRNA 107	11.0	Publications
16	TPPP3	tubulin polymerization-promoting protein family member 3	11.0	Publications
17	TM2D1	TM2 domain containing 1	11.0	Publications
18	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
19	BBC3	BCL2 binding component 3	11.0	Publications
20	GORASP1	golgi reassembly stacking protein 1, 65kDa	11.0	Publications
21	IL18BP	interleukin 18 binding protein	11.0	Publications
22	MAP3K11	mitogen-activated protein kinase kinase kinase 11	11.0	Publications
23	P2RX4	purinergic receptor P2X, ligand-gated ion channel, 4	11.0	Publications
24	CKB	creatine kinase, brain	11.0	Publications
25	KCNN4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	11.0	Publications
26	ANGPTL4	angiopoietin-like 4	11.0	Publications
27	NGB	neuroglobin	11.0	Publications
28	AQP4	aquaporin 4	11.0	Publications
29	AIF1	allograft inflammatory factor 1	11.0	Publications
30	ANKK1	ankyrin repeat and kinase domain containing 1	11.0	Publications
31	ASIC1	acid-sensing (proton-gated) ion channel 1	11.0	Functions, Publications
32	AQP7	aquaporin 7	11.0	Publications
33	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	11.0	Publications
34	AIMP1	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	11.0	Publications
35	PTGDS	prostaglandin D2 synthase 21kDa (brain)	11.0	Publications
36	GRN	granulin	11.0	Publications
37	CX3CL1	chemokine (C-X3-C motif) ligand 1	11.0	Publications
38	CYSLTR2	cysteinyl leukotriene receptor 2	11.0	Publications
39	RHOB	ras homolog family member B	11.0	Publications
40	CHRM1	cholinergic receptor, muscarinic 1	11.0	Publications
41	CYP46A1	cytochrome P450, family 46, subfamily A, polypeptide 1	11.0	Publications
42	S100B	S100 calcium binding protein B	11.0	Publications
43	KCNN1	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1	11.0	Publications
44	ACVR1B	activin A receptor, type IB	11.0	Publications
45	APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	11.0	Publications
46	APOE	apolipoprotein E	11.0	Publications
47	MIP	major intrinsic protein of lens fiber	11.0	Publications
48	DLG4	discs, large homolog 4 (Drosophila)	11.0	Publications
49	ADORA1	adenosine A1 receptor	11.0	Publications
50	FEN1	flap structure-specific endonuclease 1	11.0	Publications

Pathways related to brain injury according to GeneDecks:

(show top 50)    (show all 143)

id	Pathway	Score	Top Affiliating Genes
1	Rho Family GTPases36	11.0	BMP2, BMP6, BMP7, RAC1, BDNF, KDR
2	Pathogenesis of ALS36	11.0	BCL2, GRIN2A, GRIN2B, CASP3, CASP1, TP53
3	PGC1Alpha Pathway36	10.9	BMP2, BMP6, BMP7, BCL2, IL18, IL1A
4	TGF-Beta Pathway36	10.8	BMP2, BMP6, BMP7, BDNF, KDR, BCL2
5	DHA Signaling36	10.7	BMP2, BMP6, BMP7, BDNF, KDR, BCL2
6	Glucocorticoid Receptor Signaling36	10.7	BMP2, BMP6, BMP7, BCL2, CEBPA, JUN
7	Neuroscience3	10.7	NCAM1, BACE1, S100B, GRIN2A, GRIN2B, APBB1
8	Tec Kinases Signaling36	10.6	BMP2, BMP6, BMP7, RAC1, BDNF, BCL2
9	Molecular Mechanisms of Cancer36	10.6	BMP2, BMP6, BMP7, BDNF, KDR, BCL2
10	Endothelin-1 Signaling Pathway36	10.5	BMP2, BMP6, BMP7, IL10, IL18, IL1A
11	Neuroactive ligand-receptor interaction20	10.5	CNR1, BDKRB2, LEP, LEPR, CHRM1, P2RX4
12	PAK Pathway36	10.5	BMP2, BMP6, BMP7, RAC1, BDNF, KDR
13	Development_Leptin signaling via JAK/STAT and MAPK cascades41	10.5	LEPR, CYCS, EGR1
14	JNK Pathway36	10.5	BMP2, BMP6, BMP7, RAC1, KDR, BCL2
15	Apoptosis20	10.4	BCL2, XIAP, IL1A, IL1B, IL1R1, FASLG
16	Alzheimers disease20	10.4	BACE1, MT-CO2, MME, GRIN2A, GRIN2B, IL1B
17	ERK Signaling36	10.4	BMP2, BMP6, BMP7, IL10, IL18, IL1A
18	Renin-Angiotensin Pathway36	10.3	BMP2, BMP6, BMP7, RAC1, BDNF, KDR
19	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	10.3	MAP3K5
20	MAPK Family Pathway36	10.3	BMP2, BMP6, BMP7, RAC1, BDNF, KDR
21	Antioxidant Action of Vitamin-C36	10.3	BMP2, BMP6, BMP7, RAC1, BDNF, KDR
22	MIF Mediated Glucocorticoid Regulation36	10.2	BMP2, BMP6, BMP7, BCL2, IL10, IL18
23	all-trans-Retinoic Acid Signaling in Brain36	10.2	BMP2, BMP6, BMP7, BCL2, IL10, IL18
24	p38 Signaling36	10.2	BMP2, BMP6, BMP7, RAC1, BDNF, KDR
25	Development Leptin signaling via JAK/STAT and MAPK cascades10	10.1	LEP, LEPR, CRP, EGR1, POMC
26	Akt Signaling36	10.1	BMP2, BMP7, IL10, IL18, IL2RA, IL6
27	PEDF Induced Signaling36	10.1	BMP2, BMP6, BMP7, BDNF, BCL2, FOS
28	JAK-STAT Pathway36	10.1	BMP2, BMP6, BMP7, BDNF, KDR, JUN
29	Amyotrophic lateral sclerosis (ALS)20	10.1	RAC1, BCL2, GRIN2A, GRIN2B, MAP3K5, CASP3
30	14-3-3 Induced Apoptosis36	10.0	BCL2, JUN, FOS, IL1A, IL1B, IL1R1
31	Cellular Apoptosis Pathway36	10.0	BMP2, BMP6, BMP7, BDNF, KDR, BCL2
32	MIF Regulation of Innate Immune Cells36	10.0	BMP2, BMP6, BMP7, BCL2, JUN, FOS
33	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	10.0	MAP3K5, AKT1, CYCS, CREB1, NOS3
34	Pertussis20	9.9	JUN, FOS, IL10, IL1A, IL1B, IL6
35	STAT3 Pathway36	9.9	BMP2, BMP6, BMP7, RAC1, BCL2, IL10
36	MAPK Signaling36	9.9	BMP2, BMP6, BMP7, RAC1, BDNF, KDR
37	ILK Signaling36	9.9	BMP2, BMP7, RAC1, BDNF, KDR, JUN
38	Cytokine-cytokine receptor interaction20	9.9	VEGFA, BMP2, BMP7, KDR, LEP, LEPR
39	NOD-like receptor signaling pathway20	9.8	XIAP, IL18, IL1B, IL6, IL8, MAPK8
40	MAPK signaling pathway20	9.6	RAC1, BDNF, JUN, FOS, IL1A, IL1B
41	Pathways in cancer20	9.6	VEGFA, BMP2, RAC1, BCL2, AXIN2, CEBPA
42	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.1	BGLAP, JUN, FOS, IL1A, IL1B, IL6
43	14-3-3 Induced Intracellular Signaling36	9.1	BMP2, BMP7, BDNF, JUN, MAPT, MAPK8
44	Immune response IL-1 signaling pathway10	9.0	SERPINE1, JUN, FOS, FOSL2, IL1A, IL1B
45	Immune response_IL-1 signaling pathway41	9.0	SERPINE1, JUN, FOS, FOSL2, IL1A, IL1B
46	Influenza A20	8.9	JUN, IL18, IL1A, IL1B, IL6, IL8
47	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.8	BGLAP, JUN, FOS, IL1A, IL1B, IL6
48	Immune response MIF in innate immunity response10	8.4	JUN, IL1B, IL6, IL8, MAPK8, MAPK10
49	Immune response_MIF in innate immunity response41	8.4	JUN, IL1B, IL6, IL8, MAPK8, MAPK10
50	Chagas disease (American trypanosomiasis)20	8.3	SERPINE1, BDKRB2, JUN, FOS, IL10, IL1B

Compounds related to brain injury according to GeneDecks:

(show top 50)    (show all 545)

id	Compound	Score	Top Affiliating Genes
1	catecholamine32	11.3	CHKB, S100B, IL18, ENO2, MAOA, CAMK2G
2	acth32	11.2	BDNF, LEP, LEPR, MME, INS, IL1A
3	opiate32	11.1	MME, APP, FAS, GH1, GHRH, DRD2
4	cyclophosphamide32 34 9 9	14.0	TAC1, NPPB
5	polyethylene glycol32	10.9	SERPINC1, BMP2, CHKB, MPO, APOE, MBP
6	methamphetamine32 9 9	12.8	BDNF, MAP2, MAOA, CALB1, DRD2, NR4A1
7	spec-t32	10.7	CNR1, BMP6, CHKB, APOE, ENO2, MAPT
8	captopril32 42 9 9	13.7	BDKRB2, IL1A, APP, F3, ALB, CALCA
9	egcg32	10.7	XIAP, IL1A, APP, FASN, MAPK8, MAPK10
10	chelerythrine32	10.7	CDKN3, FOS, MBP, MAPK8, MAPK10, MAPK1
11	h2o232	10.6	VWF, BGLAP, BDNF, LEP, LEPR, BACE1
12	phenylephrine32 9 18 9	13.5	RAC1, LEP, MAOA, F2R, CAMK2G, AKT1
13	corticosterone32 18	11.5	CNR1, BGLAP, BDNF, LEPR, MPO, FOS
14	mitomycin c32	10.4	VWF, XIAP, XDH, GSR, IL18, FASLG
15	cyclic amp32 18	11.4	CNR1, BDKRB2, BDNF, CKB, CHRM1, JUN
16	dicoumarol32	10.4	PARP1, XDH, JUN, MAPK8, F2, TP53
17	adpribose32	10.4	PARP1, XIAP, FASLG, FAS, ANXA5, MAPT
18	threonine32	10.4	BMP2, BDKRB2, MT3, AXIN2, MAPT, MAP2
19	peroxynitrite32	10.3	PARP1, CHKB, XDH, MPO, GSR, CCL3
20	imatinib32 34 9 9	13.3	VEGFA, BMP6, PARP1, KDR, BCL2, XIAP
21	cocaine32 9 9	12.3	CNR1, SELP, BMP6, RABEP2, BDNF, LEP
22	carbachol32 9 9	12.2	CHRM1, MAPK10, CACNA1B, CTSB, SNCA, CRH
23	carboplatin32 34 9 9	13.2	VEGFA, PARP1, BDKRB2, KDR, BCL2, MTHFR
24	quercetin32 42 9 18 9	14.2	PARP1, BCL2, XDH, JUN, MME, GSR
25	dmso32	10.1	SELP, BMP6, BDKRB2, S100A9, XDH, MMP3
26	bromodeoxyuridine32	10.1	NCAM1, BMP6, BMP7, BDNF, LEPR, S100B
27	wortmannin32 42	10.9	BMP2, RAC1, BDNF, KDR, BCL2, LEP
28	okadaic acid32 42	10.9	BMP6, BCL2, JUN, CDKN3, FOS, MBP
29	mevalonate32	9.9	SERPINE1, BMP2, RAC1, FDFT1, IL18, FASLG
30	ketamine32 9 9	11.8	BDNF, GRIN2B, IL10, HMOX1, DRD2, PTK2B
31	leukotriene b432 42 18	11.7	SELP, RAC1, MPO, MMP9, IL1A, IL1B
32	alpha tocopherol32	9.7	BGLAP, LEP, CHKB, MTHFR, XDH, CDKN3
33	arsenite32 18	10.7	VEGFA, RAC1, BECN1, PARP1, BCL2, XIAP
34	nifedipine32 9 9	11.5	SERPINE1, BMP2, BMP6, BGLAP, BDKRB2, BDNF
35	progesterone32 42 9 18 9	13.5	NCAM1, BMP2, BMP7, BCL2, CKB, LEPR
36	gf 109203x32 42	10.4	VEGFA, JUN, CDKN3, FOS, APP, FASN
37	tgf beta132	9.2	SERPINE1, VCAN, BMP6, BMP7, KDR, MMP3
38	resveratrol32 9 18 9	12.1	VEGFA, BMP2, PARP1, BCL2, XIAP, XDH
39	lipid32	9.1	NCAM1, RETN, CNR1, SERPINE1, BMP2, BMP7
40	n acetylcysteine32	9.1	VWF, SELP, SERPINC1, BDNF, KDR, MMP3
41	acetylcholine32 9 18 9	12.0	NCAM1, CNR1, VWF, BMP6, RAC1, BDNF
42	butyrate32	8.8	BMP6, BCL2, LEP, XIAP, MPO, JUN
43	raloxifene32 9 9	10.7	VWF, SERPINC1, SERPINE1, BMP2, BGLAP, CKB
44	paclitaxel32 34 9 9	11.5	VEGFA, BMP6, RAC1, PARP1, BDNF, KDR
45	arachidonic acid32 9 18 9	11.4	NCAM1, CNR1, VWF, SELP, RAC1, BDKRB2
46	aspirin32 34 18	10.4	CNR1, VWF, SELP, SERPINC1, SERPINE1, BMP6
47	estrogen32	7.9	RETN, VWF, SERPINC1, SERPINE1, BMP2, BMP7
48	herbimycin a32 42	8.8	BMP6, JUN, CDKN3, MMP9, FOS, IL1A
49	retinoic acid32 42 18	8.7	NCAM1, VWF, SELP, SERPINE1, BMP2, BMP6
50	genistein32 9 18 9	8.7	SELP, SERPINE1, VEGFA, BMP2, RAC1, PARP1

Cellular components related to brain injury according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuronal cell body	GO:043025	10.6	DPYSL2, TAC1, SOD1, SLC6A3, SLC1A3, ADORA1
2	perikaryon	GO:043204	10.6	TH, NGB, DRD2, AIF1, GHRH, ENO2
3	perinuclear region of cytoplasm	GO:048471	9.9	HSPA5, MANF, FAS, FASLG, APBB1, CDKN3
4	cytosol	GO:005829	9.9	RHOB, NFKBIA, NFE2L2, COMT, RPS27A, NOS3
5	cell surface	GO:009986	9.7	BMP2, ACVR2A, ACVR1B, THBD, TACR1, CX3CL1
6	integral to plasma membrane	GO:005887	9.7	TACR1, THBD, AGER, ACVR1B, ACVR2A, CYSLTR1
7	cytoplasm	GO:005737	9.2	NFKBIA, NFE2L2, KRIT1, EDN1, OLIG2, EGR1
8	extracellular region	GO:005576	8.9	AGER, CALCA, CASP1, ALB, F2R, F2
9	extracellular space	GO:005615	8.2	THBD, ACE, EDN1, NGF, COL18A1, PLAT
10	plasma membrane	GO:005886	7.8	SRC, AGRN, THBD, TACR1, TAC1, CX3CL1

Biological processes related to brain injury according to GeneDecks:

(show top 50)    (show all 54)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:007267	11.2	FASLG, IL1B, IL18, IL17A, IL10, BMP2
2	aging	GO:007568	11.1	CALCA, NOS3, TSPO, ADM, EPO, SLC6A3
3	response to nicotine	GO:035094	11.1	NGF, DRD2, MMP9, BCL2, HMOX1, CNR1
4	cell death	GO:008219	11.1	HMOX1, TPP1, PDYN, TARDBP, SLC6A3, CACNA1A
5	synaptic transmission	GO:007268	11.0	COMT, CACNA1A, SLC1A1, CAMK2G, DLG4, PNOC
6	negative regulation of neuron apoptotic process	GO:043524	10.8	SNCA, GDNF, SOD2, SOD1, HIF1A, BDNF
7	positive regulation of cell proliferation	GO:008284	10.8	HTR2A, HTR1A, IGF1, FASLG, IL6, INS
8	cellular response to organic substance	GO:071310	10.8	CLEC3B, MAP2, SYP, CASP1, BCL2, IL1B
9	positive regulation of vasodilation	GO:045909	10.8	ADM, NOS1, HMOX1, CALCA, INS, NOS3
10	memory	GO:007613	10.8	S100B, IL1B, HTR2A, ASIC1, CNR1, CASP1
11	response to heat	GO:009408	10.8	NOS3, AKT1, NOS1, CALCA, CCL2, IL1B
12	positive regulation of angiogenesis	GO:045766	10.8	MMP9, F3, ANGPTL4, IL1B, IL1A, KDR
13	regulation of blood pressure	GO:008217	10.7	PTGS2, ACE, LEP, P2RX4, CALCA, NPPB
14	cellular response to hypoxia	GO:071456	10.7	HIF1A, BDKRB2, BMP7, VEGFA, TP53, BBC3
15	elevation of cytosolic calcium ion concentration	GO:007204	10.7	TAC1, ADM, EPOR, CACNA1A, KNG1, TACR1
16	sensory perception of pain	GO:019233	10.7	CNR1, NGF, TAC1, EDN1, TACR1, P2RX4
17	female pregnancy	GO:007565	10.7	ADCYAP1, CRH, ADM, LEP, IL1RN, HSD11B2
18	signal transduction	GO:007165	10.6	PTK2B, AIP, ESR1, AKT1, GMFB, CASP1
19	response to hypoxia	GO:001666	10.6	IL18, MMP9, MT3, LEP, BCL2, BMP2
20	response to lipopolysaccharide	GO:032496	10.5	COMT, CNR1, EDN1, THBD, TAC1, ADM
21	positive regulation of neuron apoptotic process	GO:043525	10.5	MAP3K11, JUN, IL18, FASLG, CASP3, TNF
22	positive regulation of renal sodium excretion	GO:035815	10.5	DRD2, EDN1, TACR1, TAC1, NPPB, KNG1
23	response to ethanol	GO:045471	10.3	CTSB, NOS3, TH, TACR1, SOD1, SLC6A3
24	angiogenesis	GO:001525	10.3	NOS3, PTEN, AIMP1, VEGFA, KDR, HMOX1
25	positive regulation of smooth muscle cell proliferation	GO:048661	10.3	HMOX1, CX3CL1, IGF1, IL6, JUN, AIF1
26	regulation of long-term neuronal synaptic plasticity	GO:048169	10.3	SYP, SYNGAP1, DRD2, GRIK2, GRIN2A, GRIN2B
27	induction of apoptosis by intracellular signals	GO:008629	10.3	AKT1, CASP3, CASP7, MAPK8, CYCS, BBC3
28	response to wounding	GO:009611	10.2	RAC1, GRIN2A, F2, F2R, CASP3, AIMP1
29	response to cocaine	GO:042220	10.2	GRIN2A, CNR1, HTR3A, DRD2, SLC6A3, GRIN2B
30	regulation of sensory perception of pain	GO:051930	10.2	F2R, CCL3, GRIN2A, IL10, ADRB2, EDN1
31	cellular response to organic cyclic compound	GO:071407	10.2	GRIN2B, CEBPA, IL1B, BMP2, TNF, CTNNB1
32	learning or memory	GO:007611	10.1	EGR1, CRH, PTEN, BDNF, S100B, GRIN2A
33	positive regulation of synaptic transmission	GO:050806	10.1	SLC1A3, TNF, CCL2, GRIN2B, GRIK2, DLG4
34	anti-apoptosis	GO:006916	10.1	BCL2, BECN1, BDNF, MPO, XIAP, SNCA
35	response to organic cyclic compound	GO:014070	10.1	NOS3, ENO2, PTGS2, CASP1, COMT, F7
36	response to mechanical stimulus	GO:009612	10.0	BGLAP, JUN, CCL2, F3, MMP9, CTSB
37	induction of apoptosis by extracellular signals	GO:008624	9.9	TNF, ADORA1, NGF, RPS27A, DAPK1, MAP3K5
38	negative regulation of apoptotic process	GO:043066	9.8	VEGFA, AIF1, TP53, TNF, PTEN, PTK2B
39	cell surface receptor signaling pathway	GO:007166	9.8	INHBA, BDKRB2, LEPR, PRL, AGER, EDN1
40	neutrophil chemotaxis	GO:030593	9.7	CCL3, IFNG, EDN1, CX3CL1, CCL2, PLA2G1B
41	negative regulation of cell proliferation	GO:008285	9.6	TNF, DRD2, PTEN, PTGS2, PTK2B, ADM
42	positive regulation of apoptotic process	GO:043065	9.5	TP53, FASLG, ANXA5, CNR1, ADRB2, KNG1
43	response to glucocorticoid stimulus	GO:051384	9.4	SERPINE1, BGLAP, PTGS2, PTGDS, PLAT, ADM
44	apoptotic process	GO:006915	9.4	TNF, TP53, AIMP1, AKT1, HRK, CASP1
45	inflammatory response	GO:006954	9.3	ADORA1, CALCA, F2R, CCL3, CCL2, IL8
46	response to drug	GO:042493	9.3	BGLAP, BDKRB2, BDNF, BCL2, JUN, MMP9
47	positive regulation of nitric oxide biosynthetic process	GO:045429	8.8	EDN1, TNF, AKT1, IFNG, IL1B, INS
48	platelet activation	GO:030168	8.6	HSPA5, ALB, AKT1, SRC, RHOB, CX3CL1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.5	IL1B, IL6, APBB1, IFNG, AKT1, IL1A
50	blood coagulation	GO:007596	8.3	NOS2, F3, F7, MAPK1, APP, RAC1

Molecular functions related to brain injury according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:008083	10.9	IL10, RABEP2, IL1B, GDNF, CSF3, NUDT6
2	hormone activity	GO:005179	10.8	EDN1, PTHLH, RETN, LEP, GH1, INS
3	drug binding	GO:008144	10.6	CNR1, CHRM1, MT3, HTR2A, GRIN2B, HTR1A
4	receptor binding	GO:005102	9.4	GDNF, ANGPTL4, CCL2, ADCYAP1, ADM, F7
5	protein homodimerization activity	GO:042803	9.4	CEBPA, GDNF, VWF, VEGFA, BMP2, BCL2
6	protease binding	GO:002020	9.4	F3, SERPINC1, IL1R1, SERPINE1, MBP, BDKRB2
7	cytokine activity	GO:005125	9.3	CSF3, VEGFA, BMP2, BMP6, BMP7, GRN
8	protein binding	GO:005515	7.0	ALB, MAPT, ANGPTL4, ENO1, FAS, FASLG