MCID: BRN071
MIFTS: 57

Brain Injury malady

Neuronal diseases category

Summaries for Brain Injury

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Sources:
45NINDS, 66Wikipedia, 34MalaCards
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Wikipedia:66 A brain injury is any injury occurring in the brain of a living organism. Brain injuries can be... more...

MalaCards: Brain Injury is related to hypertension and ischemia. An important gene associated with Brain Injury is SLC1A3 (solute carrier family 1 (glial high affinity glutamate transporter), member 3), and among its related pathways are Neurotransmitter uptake and Metabolism In Glial Cells and Glutamic acid signaling. The compounds dihydrokainate and doxycycline have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and pituitary, and related mouse phenotypes are liver/biliary system and vision/eye.

NINDS:45 Traumatic brain injury (TBI), a form of

Aliases & Classifications for Brain Injury

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Sources:
45NINDS, 32LifeMap Discoveryā„¢
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain injury 45 32


Related Diseases for Brain Injury

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Brain Injury via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.9APOE, MMP9, ACE
2ischemia30.8GDNF, HIF1A, PARP1, NOS1, SLC1A1, SLC1A3
3cerebral hypoxia30.7NOS1
4alzheimer's disease30.6APOE, NOS1, APP, GDNF, SLC1A2, SLC1A3
5schizophrenia30.5SLC1A1, GDNF, SLC1A2, SLC1A3, NOS1
6brain ischemia30.4NOS1, APP, GDNF
7dementia30.3NOS1, APP, APOE, SLC1A2, SLC1A3
8parkinson's disease30.0NOS1, PARP1, GDNF, APOE, APP
9congenital heart disease30.0HIF1A, MMP9, ACE
10cerebral amyloid angiopathy30.0APOE, APP
11epilepsy syndrome29.9NOS1, GDNF, SLC1A2, SLC1A1
12cerebrovascular disease29.9APOE, APP, ACE
13huntington's disease29.8APP, PARP1, SLC1A2, NOS1, GDNF
14traumatic brain injury11.4
15cerebritis10.9
16hypopituitarism10.8
17neuronitis10.8
18brain edema10.8
19intracranial hypertension10.6
20hypoxia10.6
21dysautonomia10.5
22head injury10.5
23post-traumatic stress disorder10.5
24spasticity10.4
25cerebral artery occlusion10.4
26hypertonia10.4
27shaken baby syndrome10.4
28diabetes insipidus10.4
29growth hormone deficiency10.4
30moderate and severe traumatic brain injury10.4
31alexithymia10.4
32chorioamnionitis10.4
33psychotic disorder10.3
34aneurysm10.3
35acute stress disorder10.3
36cerebral atrophy10.3
37spinal cord injury10.3
38endotheliitis10.3
39status epilepticus10.3
40meningitis10.3
41dysphagia10.3
42headache10.3
43memory impairment10.3
44alcohol abuse10.2
45neuroleptic malignant syndrome10.2
46learning disability10.2
47post-traumatic epilepsy10.2
48tauopathy10.2
49hypoglycemia10.2
50periventricular leukomalacia10.2

Graphical network of the top 20 diseases related to Brain Injury:



Diseases related to brain injury

Symptoms for Brain Injury

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Drugs & Therapeutics for Brain Injury

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢
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Approved drugs:

Search CenterWatch for Brain Injury

Drug clinical trials:

Search ClinicalTrials for Brain Injury

Search NIH Clinical Center for Brain Injury

Search CenterWatch for Brain Injury

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Injury:
Hematopoietic stem cells for treatment of ischemic brain injury
Embryonic/Adult Cultured Cells Related to Brain Injury:
Bone marrow-derived hematopoietic stem cells (family)

Genetic Tests for Brain Injury

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Anatomical Context for Brain Injury

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Sources:
34MalaCards
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MalaCards organs/tissues related to Brain Injury:

34
Brain, Bone, Pituitary, Cortex, Testes, Heart, Spinal cord, Endothelial, Prefrontal cortex, Eye, Monocytes, Fetal brain, T cells, Liver, Smooth muscle, Bone marrow, Myeloid, Thyroid, Hypothalamus, Lung, Kidney, Tongue, Medulla oblongata

Animal Models for Brain Injury or affiliated genes

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38MGI
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Publications for Brain Injury

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Sources:
53PubMed
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Articles related to Brain Injury:

(show top 50)    (show all 1525)
idTitleAuthorsYear
1
Resveratrol Attenuates Early Brain Injury After Subarachnoid Hemorrhage Through Inhibition of NF-I_B-Dependent Inflammatory/MMP-9 Pathway. (24279692)
2014
2
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is neuroprotective in experimental traumatic brain injury. (24392832)
2014
3
Ischemic preconditioning attenuates brain injury induced by ischemia/reperfusion during moderate hypothermia low flow procedures. (24433123)
2014
4
Discharge Planning Difficulties for Patients With Traumatic Brain Injury: Unique Funding Options. (24413072)
2014
5
Blood-brain barrier and traumatic brain injury. (24327344)
2014
6
Saccadic eye movements in mild traumatic brain injury: a pilot study. (24384339)
2014
7
Understanding practice: the factors that influence management of mild traumatic brain injury in the emergency department-a qualitative study using the Theoretical Domains Framework. (24418161)
2014
8
Risk and Mortality of Traumatic Brain Injury in Stroke Patients: Two Nationwide Cohort Studies. (24263175)
2013
9
Cognitive Impairments Accompanying Rodent Mild Traumatic Brain Injury Involve p53-Dependent Neuronal Cell Death and Are Ameliorated by the Tetrahydrobenzothiazole PFT-I+. (24312187)
2013
10
Pulmonary thrombosis associated with antidiuretic hormone replacement therapy due to secondary diabetes insipidus after traumatic brain injury: A case report. (23131855)
2013
11
Effectiveness of melatonin for sleep impairment post paediatric acquired brain injury: Evidence from a systematic review. (24102301)
2013
12
Emerging pharmacological agents to improve survival from traumatic brain injury. (24205899)
2013
13
Anaesthesiologist-provided prehospital airway management in patients with traumatic brain injury: an observational study. (24368407)
2013
14
Neuroimaging, Behavioral, and Psychological Sequelae of Repetitive Combined Blast/Impact Mild Traumatic Brain Injury in Iraq and Afghanistan War Veterans. (24102309)
2013
15
Central diabetes insipidus in pediatric severe traumatic brain injury. (23314181)
2013
16
Optimization of the pattern visual evoked potential (VEP) in the visually-normal and mild traumatic brain injury (mTBI) populations. (24111626)
2013
17
Systemic Evaluation of Hypoxic-Ischemic Brain Injury in Neonatal Rats. (24323184)
2013
18
Quality of life after traumatic brain injury: Finnish experience of the QOLIBRI in residential rehabilitation. (24002322)
2013
19
Prediction of headache severity (density and functional impact) after traumatic brain injury: A longitudinal multicenter study. (23575819)
2013
20
The negative impact of traumatic brain injury (TBI) on bone in a mouse model. (24295038)
2013
21
Assessing Neuro-Systemic & Behavioral Components in the Pathophysiology of Blast-Related Brain Injury. (24312074)
2013
22
Tamoxifen as an effective neuroprotectant against early brain injury and learning deficits induced by subarachnoid hemorrhage: possible involvement of inflammatory signaling. (24373431)
2013
23
Impact of personal and environmental factors on employment outcome two years after moderate-to-severe traumatic brain injury. (24002317)
2013
24
Hypernatremia in patients with severe traumatic brain injury: a systematic review. (24196399)
2013
25
Micronutrients in brain function, and traumatic brain injury. (24047958)
2013
26
Transcranial magnetic stimulation in brain injury. (24378049)
2013
27
Dysautonomia after pediatric brain injury. (22712762)
2012
28
Human umbilical cord blood-derived mesenchymal stem cell transplantation attenuates severe brain injury by permanent middle cerebral artery occlusion in newborn rats. (22669296)
2012
29
Elevated plasma MCP-1 concentration following traumatic brain injury as a potential "predisposition" factor associated with an increased risk for subsequent development of Alzheimer's disease. (22543850)
2012
30
Response to intracranial hypertension treatment as a predictor of death in patients with severe traumatic brain injury. (21214327)
2011
31
Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study. (21646286)
2011
32
Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivative. (21552121)
2011
33
Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats. (21695352)
2011
34
Pure red cell aplasia with phenytoin following traumatic brain injury. (21339664)
2011
35
Role of PPARs in Radiation-Induced Brain Injury. (19789638)
2010
36
Traumatic brain injury-related hypopituitarism: a review and recommendations for screening combat veterans. (20731261)
2010
37
Microemboli from cardiopulmonary bypass are associated with a serum marker of brain injury. (20437790)
2010
38
Permanent central diabetes insipidus after mild traumatic brain injury. (19891534)
2009
39
Neuroprotection of GluR5-containing kainate receptor activation against ischemic brain injury through decreasing tyrosine phosphorylation of N-methyl-D-aspartate receptors mediated by Src kinase. (18678878)
2008
40
The pre-treatment effect on brain injury during restoration of normal perfusion pressure with hemodilution in a new rat model of chronic cerebral hypoperfusion. (17535558)
2007
41
Severe traumatic brain injury complicated by status asthmaticus: favorable neurological outcome despite excessive hypercapnia. (16612314)
2006
42
Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12-month study. (16144947)
2005
43
Hypopituitarism following traumatic brain injury (TBI): call for attention. (16114279)
2005
44
Lesional expression of RhoA and RhoB following traumatic brain injury in humans. (15253798)
2004
45
Research on prevention of bilirubin-induced brain injury and kernicterus: National Institute of Child Health and Human Development conference executive summary. 2003. (15231933)
2004
46
Poly(adenosine diphosphate-ribose) polymerase expression in human traumatic brain injury. (12854754)
2003
47
Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans. (11777556)
2002
48
Relationship between acute stress disorder and posttraumatic stress disorder following mild traumatic brain injury. (9585713)
1998
49
Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. (9257663)
1997
50
Signal cascade of NGF and its application in the treatment of brain injury and neural tumor]. (8372235)
1993

Variations for Brain Injury

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Expression for genes affiliated with Brain Injury

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Injury

Search GEO for disease gene expression data for Brain Injury.

Pathways for genes affiliated with Brain Injury

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 13EMD Millipore, 55R&D Systems, 5Cell Signaling Technology, 31KEGG, 54QIAGEN
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Pathways related to Brain Injury according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1SLC1A2, SLC1A3
2
Show member pathways
9.8SLC1A2, SLC1A3, SLC1A1
3
Show member pathways
9.8EPO, HIF1A
4
Show member pathways
Angiogenesis39
9.6MMP9, HIF1A
59.6HIF1A, IL1RN, SLC1A3
6
Show member pathways
Alzheimers Disease39
9.5APP, APOE, NOS1
7
Show member pathways
Amyotrophic lateral sclerosis (ALS)39
9.5SLC1A2, SLC1A3, NOS1, SLC1A1
89.4NOS1, MMP9, GDNF
99.1APP, MMP9, ACE
108.9SLC1A2, SLC1A3, SLC1A1, NOS1, APP, APOE
118.9APOE, MMP9, APP, ACE
12
Show member pathways
8.8SLC1A6, SLC1A7, SLC1A1
138.8HIF1A, NOS1, PARP1, APOE, APP
14
Show member pathways
8.4SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
15
Show member pathways
8.2SLC1A1, SLC1A2, SLC1A6, SLC24A2, SLC1A3, SLC1A7
16
Show member pathways
7.7SLC1A2, APP, NOS1, SLC1A1, SLC1A7, SLC1A3

Compounds for genes affiliated with Brain Injury

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 25HMDB
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Compounds related to Brain Injury according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1dihydrokainate46 3011.2SLC1A2, SLC1A1, SLC1A3
2doxycycline46 1210.3MMP9, HIF1A, GDNF, EPO
3ns 39846 6210.3PARP1, MMP9, IL1RN, HIF1A
4l-nmma469.3NOS1, IL1RN, MMP9, HIF1A
5glutamine469.2APP, NOS1, SLC1A3, SLC1A1, SLC1A2, APOE
6kainate46 3010.2GDNF, SLC1A2, SLC1A1, IL1RN, SLC1A3, EPO
7folate469.1MMP9, EPO, APP, APOE, NOS1
8celecoxib46 62 30 52 25 1214.1MMP9, HIF1A, EPO, PARP1
9pdtc469.0PARP1, HIF1A, MMP9, NOS1
10nicotine46 30 52 1212.0HIF1A, APOE, MMP9, NOS1, APP
11superoxide46 259.9SLC1A3, NOS1, IL1RN, SLC1A2, HIF1A, GDNF
12aspirin46 52 30 2511.9CYSLTR1, APOE, APP, IL1RN, ACE
13iron46 259.9APP, IL1RN, SLC1A2, EPO, HIF1A, GDNF
14way 213613628.9SLC1A7, SLC1A1, SLC1A3, SLC1A6, SLC1A2
15dihydrokainic acid628.8SLC1A1, SLC1A3, SLC1A6, SLC1A2, SLC1A7
16dl-tboa62 309.8SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
17tfb-tboa628.8SLC1A2, SLC1A6, SLC1A3, SLC1A1, SLC1A7
18l-trans-2,4-pdc628.8SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
19[3h]d-aspartic acid308.8SLC1A1, SLC1A2, SLC1A6, SLC1A3, SLC1A7
20gaba468.8SLC1A2, SLC1A1, NOS1, MMP9, SLC1A3, APP
21[3h]etb-tboa308.8SLC1A2, SLC1A3, SLC1A7, SLC1A1, SLC1A6
22[3h]l-aspartic acid308.8SLC1A2, SLC1A3, SLC1A7, SLC1A1, SLC1A6
23l-glutamic acid30 25 1210.8SLC1A1, SLC1A7, SLC1A2, SLC1A6, SLC1A3
24lactacystin468.7HIF1A, PARP1, NOS1, APOE, APP, MMP9
25methotrexate52 46 1210.7HIF1A, MMP9, IL1RN, NOS1, EPO, APP
26actinomycin d468.7APP, HIF1A, GDNF, APOE, MMP9, PARP1
27adenylate468.7IL1RN, MMP9, SLC1A2, APP, SLC1A3, GDNF
28sb 20358046 629.6HIF1A, PARP1, MMP9, IL1RN, NOS1
29chloride468.6SLC1A7, SLC1A2, SLC1A6, SLC1A3, SLC1A1
30ascorbic acid46 259.6HIF1A, NOS1, IL1RN, EPO, APOE
31dopamine46 30 25 1211.6APP, GDNF, HIF1A, APOE, MMP9, NOS1
32cyclosporin a46 30 6210.5HIF1A, APP, EPO, APOE, IL1RN, NOS1
33nitric oxide46 25 1210.4HIF1A, SLC1A2, SLC1A3, NOS1, IL1RN, ACE
34phosphatidylinositol468.4CYSLTR1, GDNF, EPO, MMP9, IL1RN, SLC1A1
35norepinephrine46 25 1210.4IL1RN, SLC1A2, ACE, MMP9, APP, GDNF
36testosterone46 62 25 1211.4APOE, NOS1, HIF1A, IL1RN, MMP9, EPO
37cycloheximide468.4APOE, MMP9, PARP1, IL1RN, NOS1, HIF1A
38h2o2468.4APP, SLC1A2, NOS1, IL1RN, PARP1, APOE
39oxygen46 259.2IL1RN, HIF1A, EPO, GDNF, NOS1, PARP1
40dexamethasone46 52 30 1211.1NOS1, IL1RN, MMP9, PARP1, APP, HIF1A
41retinoic acid46 259.1APP, NOS1, IL1RN, SLC1A1, MMP9, PARP1
42creatinine468.1MMP9, EPO, ACE, IL1RN, NOS1, GDNF
43nmda46 308.9IL1RN, NOS1, SLC1A1, APP, SLC1A3, SLC1A2
44alanine467.9IL1RN, SLC1A1, SLC1A2, SLC1A3, NOS1, MMP9
45vegf467.9GDNF, APOE, APP, PARP1, EPO, MMP9
46serine467.8NOS1, SLC1A2, SLC1A3, GDNF, HIF1A, APOE
47sodium46 258.8ACE, GDNF, SLC1A1, SLC1A7, SLC1A3, SLC24A2
48aspartate467.7SLC1A2, SLC1A6, SLC1A3, SLC1A1, MMP9, APOE
49cysteine467.3MMP9, PARP1, SLC1A1, NOS1, IL1RN, SLC24A2
50glutamate466.9SLC1A1, IL1RN, APP, MMP9, NOS1, APOE

GO Terms for genes affiliated with Brain Injury

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Sources:
17Gene Ontology
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Cellular components related to Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:0160208.9SLC1A2, SLC1A6, SLC1A3, SLC1A1, CYSLTR1
2extracellular spaceGO:0056158.7IL1RN, ACE, MMP9, EPO, APOE
3extracellular regionGO:0055768.0MMP9, EPO, APP, APOE, GDNF, ACE
4plasma membraneGO:0058866.5SLC24A2, SLC1A7, SLC1A6, SLC1A2, SLC1A1, IL1RN

Biological processes related to Brain Injury according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1D-aspartate importGO:07077910.1SLC1A2, SLC1A3, SLC1A1
2L-glutamate importGO:05193810.1SLC1A1, SLC1A3, SLC1A2
3negative regulation of calcium ion transport into cytosolGO:01052310.1NOS1, EPO
4hemoglobin biosynthetic processGO:04254110.0EPO, HIF1A
5positive regulation of nitric-oxide synthase activityGO:0510009.9HIF1A, APOE
6regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.8EPO, HIF1A
7macrophage differentiationGO:0302259.7PARP1, MMP9
8nitric oxide mediated signal transductionGO:0072639.6NOS1, APOE
9negative regulation of neuron apoptotic processGO:0435249.6GDNF, HIF1A, APOE
10L-glutamate transportGO:0158139.2SLC1A7, SLC1A6
11synaptic transmissionGO:0072689.1SLC1A1, SLC1A3, SLC1A6, SLC1A2
12positive regulation of transcription from RNA polymerase II promoterGO:0459448.9NOS1, PARP1, APP, HIF1A, GDNF
13ion transportGO:0068118.4SLC1A2, SLC1A1, SLC1A7, SLC1A3, SLC24A2, SLC1A6
14transmembrane transportGO:0550858.4SLC1A1, SLC1A7, SLC1A3, SLC24A2, SLC1A6, SLC1A2

Molecular functions related to Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate:sodium symporter activityGO:01550110.0SLC1A1, SLC1A2
2cadmium ion bindingGO:0468709.8SLC24A2, NOS1
3glutamate bindingGO:0165959.8SLC1A3, SLC1A1
4identical protein bindingGO:0428029.1MMP9, PARP1, APP, APOE
5sodium:dicarboxylate symporter activityGO:0171538.5SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
6L-glutamate transmembrane transporter activityGO:0053138.5SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2

Products for genes affiliated with Brain Injury

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  • Antibodies
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Sources for Brain Injury

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet