MCID: BRN071
MIFTS: 57

Brain Injury malady

Neuronal category

Summaries for Brain Injury

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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Wikipedia:64 A brain injury is any injury occurring in the brain of a living organism. Brain injuries can be... more...

MalaCards: Brain Injury is related to brain edema and brain ischemia. An important gene associated with Brain Injury is EPO (erythropoietin), and among its related pathways are Neuroscience and SLC-mediated transmembrane transport. The compounds cysteine and vegf have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are cellular and behavior/neurological.

NINDS:44 Traumatic brain injury (TBI), a form of

Aliases & Classifications for Brain Injury

Sources:
44NINDS, 31LifeMap Discovery™
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

brain injury 44 31


Related Diseases for Brain Injury

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Brain Injury via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 260)
idRelated DiseaseScoreTop Affiliating Genes
1brain edema31.2MIP, MMP9
2brain ischemia30.9NOS1, APP
3cerebral hypoxia30.6NOS1
4chorioamnionitis30.5IL1RN
5stroke, ischemic30.4S100B, APOE, MMP9, ACE, PARP1
6alzheimer's disease30.2S100B, APP, APOE, SLC1A2, SLC1A3, NOS1
7neonatal hypoxic and ischemic brain injury30.2ENO2, SLC1A3
8persistent vegetative state30.2ENO2
9hemorrhage, intracerebral30.1APP, APOE, ENO2
10asthma29.8CYSLTR1, MMP9, NOS1, PARP1
11vascular disease29.8APOE, MMP9, ACE, PARP1
12cerebral amyloid angiopathy29.8APOE, APP
13parkinson's disease29.8APP, APOE, NOS1, PARP1
14amyloidosis29.8APOE, APP
15insulin resistance29.8MIP, ACE
16huntington's disease29.8SLC1A2
17sickle cell disease29.8EPO
18traumatic brain injury11.4
19head injury10.6
20brain disease10.6
21hypoxia10.6
22post-traumatic stress disorder10.6
23dysautonomia10.5
24cerebral artery occlusion10.4
25hypertonia10.4
26shaken baby syndrome10.4
27diabetes insipidus10.4
28alexithymia10.4
29growth hormone deficiency10.4
30n syndrome10.3
31cerebral atrophy10.3
32spinal cord injury10.3
33acute stress disorder10.3
34spasticity10.3
35status epilepticus10.3
36transient cerebral ischemia10.3
37dysphagia10.3
38headache10.3
39memory impairment10.3
40alcohol abuse10.2
41hypoglycemia10.2
42neuroleptic malignant syndrome10.2
43brain cancer10.2
44post-traumatic epilepsy10.2
45periventricular leukomalacia10.1
46agnosia10.1
47tauopathy10.1
48bilirubin induced brain injury in the newborn10.1
49leukomalacia10.1
50wallerian degeneration10.1

Graphical network of the top 20 diseases related to Brain Injury:



Diseases related to brain injury

Clinical Features for Brain Injury

Drugs & Therapeutics for Brain Injury

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Brain Injury

Drug clinical trials:

Search ClinicalTrials for Brain Injury

Search NIH Clinical Center for Brain Injury

Search CenterWatch for Brain Injury

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Injury:
Hematopoietic stem cells for treatment of ischemic brain injury
Embryonic/Adult Cultured Cells Related to Brain Injury:
Bone marrow-derived hematopoietic stem cells (family)

Genetic Tests for Brain Injury

Anatomical Context for Brain Injury

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Brain Injury:

33
Bone marrow, Whole blood, Brain, Cortex, Spinal cord, Heart, Smooth muscle, Small intestine, Kidney, Liver, Lung, Thyroid, Myeloid, Monocytes, T cells, B cells, Endothelial, Fetal brain, Prefrontal cortex, Olfactory bulb, Hypothalamus, Medulla oblongata, Tongue, Fetal liver, Fetal lung, Fetal thyroid, Adrenal cortex, Pituitary

Animal Models for Brain Injury or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Brain Injury

Sources:
51PubMed
See all sources

Articles related to Brain Injury:

(show top 50)    (show all 1741)
idTitleAuthorsYear
1
Preliminary examination of the impact of traumatic brain injury and posttraumatic stress disorder on self-regulated learning and academic achievement among military service members enrolled in postsecondary education. (23982790)
2014
2
Does the mild traumatic brain injury (mTBI) research need to be internationalized right now? (24284808)
2014
3
Time-dependent effect of combination therapy with erythropoietin and granulocyte colony-stimulating factor in a mouse model of hypoxic-ischemic brain injury. (24435306)
2014
4
The complex management of a traumatic brain injury and aortic injury after a motor vehicle crash: a case report. (24399313)
2014
5
Adult functioning of mothers with traumatic brain injury at high risk of child abuse: A pilot study. (24401827)
2014
6
Alteration in BDNF and its receptors, full-length and truncated TrkB and p75(NTR) following penetrating traumatic brain injury. (24192075)
2014
7
Tamoxifen as an effective neuroprotectant against early brain injury and learning deficits induced by subarachnoid hemorrhage: possible involvement of inflammatory signaling. (24373431)
2013
8
Influence of post-traumatic stress disorder on neuroinflammation and cell proliferation in a rat model of traumatic brain injury. (24349091)
2013
9
Traumatic brain injury, neuroinflammation, and post-traumatic headaches. (24090534)
2013
10
The Physiologic Effects of Indomethacin Test on CPP and ICP in Severe Traumatic Brain Injury (sTBI). (24233815)
2013
11
Factors affecting participation after traumatic brain injury. (24002312)
2013
12
Apoptosis signal-regulating kinase 1 (ASK1) is linked to neural stem cell differentiation after ischemic brain injury. (24357833)
2013
13
Genetic influences and neuropathological sequelae of repetitive brain injury. (24243027)
2013
14
Foxo3a transcriptionally upregulates AQP4 and induces cerebral edema following traumatic brain injury. (24174672)
2013
15
Stimulus over-selectivity in temporal brain injury: mindfulness as a potential intervention. (24266796)
2013
16
Prostaglandin F2I+ FP receptor antagonist improves outcomes after experimental traumatic brain injury. (24172576)
2013
17
Outcomes following prehospital airway management in severe traumatic brain injury. (24300684)
2013
18
Pharmacotherapy refractory insomnia in soldiers with traumatic brain injury. (23381336)
2013
19
Long-term neurological and neuropsychological outcome in patients with severe traumatic brain injury. (24184064)
2013
20
Hippocampal volume reduction correlates with apathy in traumatic brain injury, but not schizophrenia. (24247856)
2013
21
Severe traumatic brain injury. Author reply. (24137781)
2013
22
Smooth Muscle Phenotype Switching in Blast Traumatic Brain Injury-Induced Cerebral Vasospasm. (24323722)
2013
23
Superimposed traumatic brain injury modulates vasomotor responses in third-order vessels after hemorrhagic shock. (24257108)
2013
24
Acute Alcohol Intoxication Prolongs Neuroinflammation without Exacerbating Neurobehavioral Dysfunction following Mild Traumatic Brain Injury. (24050411)
2013
25
Effect of minimized perfusion circuit on brain injury markers carnosinase and brain-type fatty binding protein in coronary artery bypass grafting patients. (23020859)
2013
26
Lateralized response of dynorphin a peptide levels after traumatic brain injury. (22468884)
2012
27
Genetics and outcomes after traumatic brain injury (TBI): what do we know about pediatric TBI? (23023254)
2012
28
Pure red cell aplasia with phenytoin following traumatic brain injury. (21339664)
2011
29
Ophthalmoplegia associated with transorbital penetrating brainstem injury by broken fishing pole. (21792279)
2011
30
Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. (21658430)
2011
31
Hypopituitarism following traumatic brain injury: determining factors for diagnosis. (22649368)
2011
32
Chronic cognitive sequelae after traumatic brain injury are not related to growth hormone deficiency in adults. (20050894)
2010
33
Apolipoprotein E polymorphism and outcome after mild to moderate traumatic brain injury: a study of patient population in India. (20508347)
2010
34
Traumatic brain injury may increase the risk for frontotemporal dementia through reduced progranulin. (20145419)
2009
35
Brain injury does not alter the intrinsic differentiation potential of adult neuroblasts. (19386903)
2009
36
Cerebral apoptosis in severe traumatic brain injury patients: an in vitro, in vivo, and postmortem study. (18363508)
2008
37
NKCC1-mediated traumatic brain injury-induced brain edema and neuron death via Raf/MEK/MAPK cascade. (18431281)
2008
38
Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study. (18698520)
2008
39
Activation of Nrf2-ARE pathway in brain after traumatic brain injury. (18162315)
2008
40
The pre-treatment effect on brain injury during restoration of normal perfusion pressure with hemodilution in a new rat model of chronic cerebral hypoperfusion. (17535558)
2007
41
Effects of Anemarrhena asphodeloides on focal ischemic brain injury induced by middle cerebral artery occlusion in rats. (17202656)
2007
42
Alteration in brain natriuretic peptide (BNP) plasma concentration following severe traumatic brain injury. (16322908)
2006
43
"Frog, where are you?" Narratives in children with specific language impairment, early focal brain injury, and Williams syndrome. (14965544)
2004
44
Effect of hypothermia on serum electrolyte, inflammation, coagulation, and nutritional parameters in patients with severe traumatic brain injury. (16174912)
2004
45
Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans. (11777556)
2002
46
Early neonatal brain injury in histologic chorioamnionitis. (11148520)
2001
47
Cellular stress and injury responses in the brains of adult Vietnamese patients with fatal Plasmodium falciparum malaria. (11903925)
2001
48
Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury. (11424956)
2000
49
Differential effect of a dopaminergic agonist on prefrontal function in traumatic brain injury patients. (9648550)
1998
50
Induction of c-fos mRNA and protein in neurons and glia after traumatic brain injury: pharmacological characterization. (2106445)
1990

Genetic Variations for Brain Injury

Expression for genes affiliated with Brain Injury

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Brain Injury

Search GEO for disease gene expression data for Brain Injury.

Pathways for genes affiliated with Brain Injury

Sources:
4Cell Signaling Technology, 54Reactome, 30KEGG, 52QIAGEN, 53R&D Systems, 12EMD Millipore
See all sources

Compounds for genes affiliated with Brain Injury

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Brain Injury according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1cysteine4512.0S100B, APP, APOE, MIP, IL1RN, MMP9
2vegf4511.8S100B, APP, APOE, MIP, EPO, IL1RN
3alanine4511.8S100B, APP, APOE, IL1RN, MMP9, SLC1A2
4calcium45 50 11 2414.7S100B, MIP, CYSLTR1, IL1RN, MMP9, SLC1A2
5sodium45 2412.7MIP, SLC1A7, SLC1A2, SLC1A1, SLC24A2, SLC1A6
6dexamethasone45 50 29 1114.7S100B, APP, MIP, CYSLTR1, IL1RN, MMP9
7gaba4511.6S100B, APP, MMP9, SLC1A2, SLC1A1, SLC1A3
8glutamine4511.6S100B, APP, APOE, SLC1A2, SLC1A1, SLC1A3
9adenylate4511.6S100B, APP, IL1RN, MMP9, SLC1A2, SLC1A3
10lipid4511.6S100B, APP, APOE, MIP, ENO2, ACE
11glutamate4511.6SLC1A3, APP, MIP, SLC1A7, SLC1A2, SLC1A1
12testosterone45 60 11 2414.5S100B, APP, APOE, EPO, IL1RN, MMP9
13aspartate4511.5APP, APOE, SLC1A2, SLC1A1, SLC1A6, SLC1A3
14nmda45 2912.5APP, APOE, SLC1A7, SLC1A2, SLC1A1, SLC1A3
15creatinine4511.5APP, APOE, EPO, IL1RN, MMP9, NOS1
16nitric oxide45 11 2413.5S100B, MIP, IL1RN, SLC1A2, SLC1A3, NOS1
17chloride4511.5MIP, SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
18lactate4511.4S100B, MIP, EPO, IL1RN, MMP9, SLC1A2
19formaldehyde45 2412.4S100B, APP, IL1RN, MMP9, NOS1, ENO2
20retinoic acid45 2412.4S100B, APP, IL1RN, MMP9, SLC1A1, NOS1
21[3h]etb-tboa2911.4SLC1A2, SLC1A1, SLC1A6, SLC1A3, SLC1A7
22l-trans-2,4-pdc6011.4SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
23[3h]l-aspartic acid2911.4SLC1A3, SLC1A6, SLC1A7, SLC1A2, SLC1A1
24[3h]d-aspartic acid2911.4SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
25methotrexate45 50 1113.4APP, EPO, IL1RN, MMP9, NOS1, ENO2
26way 2136136011.4SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
27dihydrokainic acid6011.4SLC1A1, SLC1A6, SLC1A3, SLC1A2, SLC1A7
28dl-tboa60 2912.4SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
29tfb-tboa6011.4SLC1A3, SLC1A7, SLC1A2, SLC1A1, SLC1A6
30h2o24511.4APP, APOE, MIP, IL1RN, SLC1A2, NOS1
31l-glutamic acid29 11 2413.3SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
32lactacystin4511.3APP, APOE, MMP9, NOS1, PARP1
33oxygen45 2412.3S100B, MIP, EPO, SLC1A2, NOS1, PARP1
34dopamine45 29 11 2414.2APP, MMP9, SLC1A2, NOS1, ENO2
35kainate45 2912.2APOE, SLC1A2, SLC1A1, SLC1A3
36norepinephrine45 11 2413.2S100B, APP, SLC1A2
37folate4511.1APP, APOE, EPO, MMP9, NOS1
383-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4511.1S100B, APP, MMP9, PARP1
39dihydrokainate45 2912.1SLC1A2, SLC1A1, SLC1A3
40acetylcholine45 50 29 11 2415.1APP, NOS1, ACE, ENO2
41aspirin45 50 29 2414.1APP, APOE, CYSLTR1, IL1RN, ACE
42cyclosporin a45 29 6013.1NOS1, APP, S100B
43serine4511.1S100B, APP, IL1RN, MMP9, SLC1A2, SLC1A3
44iron45 2412.1S100B, APP, EPO, SLC1A2, ENO2
45edss4511.1ENO2, APOE, S100B
46dbc-amp4510.9S100B, SLC1A2, SLC1A3, ENO2
47ascorbic acid45 2411.9S100B, APOE, EPO, IL1RN, NOS1
48threo-3-methylglutamate2910.7SLC1A6, SLC1A2
49indomethacin45 60 29 1113.5NOS1
50threo-beta-hydroxyaspartate4510.4SLC1A3, SLC1A1

GO Terms for genes affiliated with Brain Injury

Sources:
16Gene Ontology
See all sources

Cellular components related to Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.3ENO2, APP, APOE, MIP, CYSLTR1, IL1RN
2extracellular spaceGO:00561511.0APOE, EPO, IL1RN, MMP9, ACE, S100B

Biological processes related to Brain Injury according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1ion transportGO:00681111.2SLC1A3, SLC1A6, SLC24A2, SLC1A1, SLC1A2, SLC1A7
2transmembrane transportGO:05508511.2MIP, SLC1A7, SLC1A2, SLC1A1, SLC24A2, SLC1A6
3D-aspartate importGO:07077910.9SLC1A2, SLC1A1, SLC1A3
4L-glutamate importGO:05193810.9SLC1A3, SLC1A1, SLC1A2
5negative regulation of calcium ion transport into cytosolGO:01052310.7NOS1, EPO
6regulation of neuronal synaptic plasticityGO:04816810.7APOE, S100B
7memoryGO:00761310.6S100B, IL1RN, SLC24A2
8L-glutamate transportGO:01581310.4SLC1A6, SLC1A7

Molecular functions related to Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:dicarboxylate symporter activityGO:01715311.0SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
2L-glutamate transmembrane transporter activityGO:00531311.0SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
3identical protein bindingGO:04280210.8S100B, APP, APOE, MMP9, PARP1
4glutamate:sodium symporter activityGO:01550110.7SLC1A2, SLC1A1
5glutamate bindingGO:01659510.7SLC1A3, SLC1A1
6tau protein bindingGO:04815610.4APOE, S100B

Products for genes affiliated with Brain Injury

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brain Injury

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet