Aliases & Classifications for Brain Injury

MalaCards integrated aliases for Brain Injury:

Name: Brain Injury 37 50

Classifications:



Summaries for Brain Injury

NINDS : 50 Traumatic brain injury (TBI), a form of acquired brain injury, occurs when a sudden trauma causes damage to the brain. TBI can result when the head suddenly and violently hits an object, or when an object pierces the skull and enters brain tissue.  Symptoms of a TBI can be mild, moderate, or severe, depending on the extent of the damage to the brain. A person with a mild TBI may remain conscious or may experience a loss of consciousness for a few seconds or minutes. Other symptoms of mild TBI include headache, confusion, lightheadedness, dizziness, blurred vision or tired eyes, ringing in the ears, bad taste in the mouth, fatigue or lethargy, a change in sleep patterns, behavioral or mood changes, and trouble with memory, concentration, attention, or thinking.  A person with a moderate or severe TBI may show these same symptoms, but may also have a headache that gets worse or does not go away, repeated vomiting or nausea, convulsions or seizures, an inability to awaken from sleep, dilation of one or both pupils of the eyes, slurred speech, weakness or numbness in the extremities, loss of coordination, and increased confusion, restlessness, or agitation.

MalaCards based summary : Brain Injury is related to neonatal hypoxic and ischemic brain injury and head injury. An important gene associated with Brain Injury is ASIC1 (Acid Sensing Ion Channel Subunit 1), and among its related pathways/superpathways are Jak-STAT signaling pathway (KEGG) and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Midazolam and Propofol have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Wikipedia : 72 A brain injury is an injury to the brain of a living organism, and can be categorized by many... more...

Related Diseases for Brain Injury

Diseases related to Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 332)
# Related Disease Score Top Affiliating Genes
1 neonatal hypoxic and ischemic brain injury 33.9 BDNF ENO2 MBP
2 head injury 32.7 APOE ENO2 S100B
3 persistent vegetative state 32.4 APOE ENO2
4 periventricular leukomalacia 32.3 EPO IL6 MBP
5 alzheimer disease 30.3 APOE BDNF CASP3 GFAP MAPT S100B
6 status epilepticus 30.1 BDNF CASP3 ENO2 GFAP
7 leukomalacia 30.0 EPO IL6 MBP
8 spinal cord injury 30.0 BDNF CASP3 GFAP IL6
9 bacterial meningitis 29.8 IL10 IL6 S100B
10 akinetic mutism 29.8 ENO2 MAPT
11 post-traumatic stress disorder 29.7 BDNF COMT DRD2
12 traumatic brain injury 29.5 APOE BDNF CASP3 COMT DRD2 ENO2
13 psychotic disorder 29.4 BDNF COMT DRD2 S100B
14 personality disorder 29.1 BDNF COMT DRD2
15 paranoid schizophrenia 29.1 BDNF COMT S100B
16 hydrocephalus 29.1 APOE ENO2 GFAP IGF1 MAPT MBP
17 substance abuse 28.9 BDNF COMT DRD2
18 multiple sclerosis 28.6 APOE BDNF GFAP IL10 IL6 MBP
19 mood disorder 28.6 BDNF COMT DRD2 IL6
20 major depressive disorder 28.5 BDNF COMT DRD2 IL6
21 disease of mental health 28.2 APOE BDNF COMT DRD2 MAPT
22 bipolar disorder 27.9 BDNF COMT DRD2 IGF1 MAPT
23 moderate and severe traumatic brain injury 12.3
24 bilirubin induced brain injury in the newborn 12.1
25 pseudobulbar affect 11.1
26 agnosia 11.1
27 locked-in syndrome 11.1
28 cerebral hypoxia 11.0
29 shaken baby syndrome 11.0
30 dysphagia 11.0
31 cerebral atrophy 11.0
32 epilepsy 11.0
33 apraxia 11.0
34 post-traumatic epilepsy 11.0
35 swallowing disorders 11.0
36 speech and communication disorders 11.0
37 west syndrome 11.0
38 tremor 11.0
39 prosopagnosia, hereditary 10.8
40 ocular motor apraxia 10.7
41 diarrhea 5, with tufting enteropathy, congenital 10.7
42 microcephaly 10.7
43 dyslexia 10.7
44 prosopagnosia 10.7
45 childhood apraxia of speech 10.7
46 dementia pugilistica 10.7
47 vibrio vulnificus infection 10.6 EPO IL6
48 bednar tumor 10.5 ENO2 S100B
49 primitive neuroectodermal tumor of the cervix uteri 10.5 ENO2 GFAP
50 intracranial cysts 10.5 ENO2 GFAP S100B

Graphical network of the top 20 diseases related to Brain Injury:



Diseases related to Brain Injury

Symptoms & Phenotypes for Brain Injury

GenomeRNAi Phenotypes related to Brain Injury according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 CASP3 IGF1 IL10
2 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1

MGI Mouse Phenotypes related to Brain Injury:

43 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.45 ASIC1 BDNF COMT DRD2 GFAP APOE
2 homeostasis/metabolism MP:0005376 10.39 EPO COMT BDNF DRD2 GFAP APOE
3 cellular MP:0005384 10.37 EPO BDNF DRD2 GFAP APOE CASP3
4 cardiovascular system MP:0005385 10.35 EPO COMT DRD2 GFAP APOE CASP3
5 growth/size/body region MP:0005378 10.35 ENO2 IGF1 BDNF DRD2 GFAP APOE
6 nervous system MP:0003631 10.31 ASIC1 BDNF COMT DRD2 GFAP APOE
7 mortality/aging MP:0010768 10.27 CASP3 EPO BDNF DRD2 GFAP APOE
8 hematopoietic system MP:0005397 10.26 CASP3 EPO COMT DRD2 APOE IGF1
9 immune system MP:0005387 10.24 CASP3 COMT EPO DRD2 GFAP APOE
10 integument MP:0010771 10.22 EPO BDNF DRD2 APOE CASP3 IGF1
11 digestive/alimentary MP:0005381 10.15 CASP3 BDNF DRD2 GFAP APOE IL6
12 muscle MP:0005369 10.09 IGF1 EPO DRD2 GFAP APOE CASP3
13 normal MP:0002873 10.07 IGF1 EPO BDNF DRD2 GFAP IL10
14 renal/urinary system MP:0005367 9.92 COMT DRD2 APOE CASP3 IGF1 IL6
15 reproductive system MP:0005389 9.91 APOE CASP3 COMT BDNF DRD2 IGF1
16 respiratory system MP:0005388 9.9 EPO BDNF COMT DRD2 APOE CASP3
17 taste/olfaction MP:0005394 9.43 BDNF DRD2 APOE CASP3 ENO2 MAPT
18 vision/eye MP:0005391 9.28 BDNF GFAP APOE CASP3 IL6 IL10

Drugs & Therapeutics for Brain Injury

Drugs for Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 608)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 59467-70-8 4192
2
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 2078-54-8 4943
3
Zinc Approved, Investigational Phase 4,Phase 2 7440-66-6 32051 23994
4
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 6251 453
5
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
6
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
7
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
8
Amantadine Approved Phase 4,Phase 2,Phase 3,Phase 1 768-94-5 2130
9
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
10
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
11
Ticlopidine Approved Phase 4 55142-85-3 5472
12
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
13
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 76631-46-4, 113775-47-6 5311068 56032 68602
14
Remifentanil Approved Phase 4 132875-61-7 60815
15
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Phase 1 28523-86-6 5206
16
Sufentanil Approved, Investigational Phase 4,Phase 2 56030-54-7 41693
17 Cisatracurium Approved, Experimental Phase 4 96946-41-7
18
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
19
Levodopa Approved Phase 4,Phase 1,Phase 2 59-92-7 6047
20
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
21
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 1 99-66-1 3121
22
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2 1197-18-8 5526
23
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
24
Memantine Approved, Investigational Phase 4,Phase 2 19982-08-2 4054
25
Etomidate Approved Phase 4 33125-97-2 667484 36339
26
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2 437-38-7 3345
27
Baclofen Approved Phase 4,Phase 3,Phase 2,Phase 1 1134-47-0 2284
28
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-84-3 187
29
Methylphenidate Approved, Investigational Phase 4,Phase 2,Phase 1 20748-11-2, 113-45-1 4158
30
Norepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-41-2 439260
31
Heparin Approved, Investigational Phase 4,Phase 2,Phase 1 9005-49-6 46507594 772
32
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1 64-17-5 702
33
Acetaminophen Approved Phase 4,Phase 2 103-90-2 1983
34
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
35
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 657311 5754
36 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 329-65-7
37
Ibuprofen Approved Phase 4,Phase 3,Phase 2 15687-27-1 3672
38
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 1 525-66-6 4946
39
Rivastigmine Approved, Investigational Phase 4,Phase 3 123441-03-2 77991
40
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
41
Methyltestosterone Approved Phase 4,Phase 2 58-18-4 6010
42
Testosterone Approved, Investigational Phase 4,Phase 2 58-22-0 6013
43
Dalteparin Approved Phase 4,Phase 2 9005-49-6
44
Topiramate Approved Phase 4,Phase 1,Early Phase 1 97240-79-4 5284627
45
Fosphenytoin Approved, Investigational Phase 4 93390-81-9 56339
46
Phenytoin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 57-41-0 1775
47 Piracetam Approved, Investigational Phase 4,Phase 3,Phase 2 7491-74-9
48
Dextromethorphan Approved Phase 4,Phase 3 125-71-3 5362449 5360696
49
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
50
Quinidine Approved, Investigational Phase 4,Phase 2 56-54-2 441074

Interventional clinical trials:

(show top 50) (show all 2245)

# Name Status NCT ID Phase Drugs
1 A Comparison of Propofol Versus Midazolam to Sedate Critically Brain Injury; Measurement of Cytokine Response and Assessment of Function Unknown status NCT01712477 Phase 4 Intravenous sedation using propofol;Intravenous sedation with midazolam
2 Effect of Rozerem on Sleep Among People With Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
3 Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury Unknown status NCT02161055 Phase 4 Insulin
4 The CAPTAIN Trial: Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery Unknown status NCT01606111 Phase 4 Cerebrolysin;0.9% NaCl, saline
5 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
6 Normothermia in Patients With Acute Cerebral Damage Unknown status NCT00491192 Phase 4 Diclofenac
7 Antidepressant Maintenance in Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
8 Growth Hormone and Brain Functioning After Traumatic Brain Injury Unknown status NCT01699308 Phase 4 Genotropin (somatropin)
9 Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State Unknown status NCT00163878 Phase 4
10 Amantadine for Treatment of Symptoms of the Post-Traumatic Confusional State Unknown status NCT00693121 Phase 4 Amantadine hydrochloride;Placebo capsule
11 Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
12 The Effect of Dexmedetomidine to Cognition of Geriatrics in Prolonged Surgery Unknown status NCT02123355 Phase 4 Induction of anesthesia;Sevoflurane, remifentanil ,vecuronium;Dexmedetomidine;Placebo
13 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
14 Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma? Unknown status NCT01470040 Phase 4 discontinuation of aspirin therapy;continuation of aspirin therapy
15 Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
16 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
17 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
18 TXA in the EMS on the Helicopter and the Ambulance Unknown status NCT02354885 Phase 4 Tranexamic Acid
19 Tramadol Extended-Release (ER) for Posttraumatic Stress Disorder (PTSD) Unknown status NCT01517711 Phase 4 Tramadol;Placebo
20 Creative Therapy to Affect Stroke Outcomes Unknown status NCT01455155 Phase 4
21 Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:A Randomized Controlled Trial Unknown status NCT00196703 Phase 4 memantine
22 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
23 A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive Function in Elderly Patients Unknown status NCT02147678 Phase 4 Etomidate;Propofol;Remifentanil;Anesthesia induction
24 Sevoflurane Decreases the Risk of Postoperative Delirium After Cerebral Hypoxemia During Surgery Unknown status NCT02133638 Phase 4 Sevoflurane;Propofol
25 Does Oral Baclofen Improve Care and Comfort in Spastic Children in Nursing Homes? Unknown status NCT00752934 Phase 4 oral baclofen + placebo;placebo + oral baclofen
26 Consequence of Dexmedetomidine on Emergence Deliruim After Sevoflurane Anesthesia in Children With Cerebral Palsy Unknown status NCT02244515 Phase 4 dexmedetomidine
27 The Efficacy and Safety of MEDITOXIN® in Children With Cerebral Palsy Unknown status NCT01256021 Phase 4 Botulinum Toxin Type A
28 Effects of Functional Electrical Stimulation on Gait in Children With Cerebral Palsy Unknown status NCT02462018 Phase 4
29 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury Completed NCT00957671 Phase 4 Human Growth Hormone;Placebo
30 Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon Completed NCT03401515 Phase 4 Propranolol Hydrochloride 1 MG/ML
31 An Extension Study Evaluating the Efficacy and Safety of Rivastigmine in Patients With Traumatic Brain Injury (TBI) With Persistent Cognitive Deficits Completed NCT00219245 Phase 4 Rivastigmine
32 Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery Completed NCT00035139 Phase 4 methylphenidate
33 Intravenous Exenatide in Patients With Acute Brain Injury Completed NCT02058940 Phase 4 Exenatide
34 Pharmacological Intervention in Depression After Traumatic Brain Injury Completed NCT00205491 Phase 4 Venlafaxine
35 The Relationship Between Traumatic Brain Injury and Dopamine (a Chemical in the Brain) Completed NCT02015949 Phase 4 Methylphenidate;Placebo
36 The Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury Completed NCT01339806 Phase 4
37 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel);Androgel Placebo
38 Depression and Traumatic Brain Injury Completed NCT00254007 Phase 4 citalopram (celexa)
39 The Use of Low Molecular Weight Heparin in Traumatic Brain Injury Completed NCT00170378 Phase 4 Enoxaparin
40 Optimized Therapy in Severe Traumatic Brain Injured Patients Completed NCT02130674 Phase 4 Dipeptiven
41 Effect of Erythropoietin on Preterm Brain Injury Completed NCT02036073 Phase 4 recombinant human erythropoietin
42 Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI Completed NCT01750268 Phase 4 Topiramate;Placebo
43 Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention Completed NCT00618436 Phase 4 Levetiracetam;Phenytoin
44 Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA) Completed NCT01799941 Phase 4 Nuedexta (DM 20 mg/Q 10 mg)
45 Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity Completed NCT00178646 Phase 4 Botox
46 Melatonin to Prevent Brain Injury in Unborn Growth Restricted Babies Completed NCT01695070 Phase 4 Melatonin
47 BOTOX® Versus Zanaflex® for the Treatment of Post-Stroke or Traumatic Brain Injury Upper Limb Spasticity Completed NCT00430196 Phase 4 BOTOX®;Zanaflex®
48 Enteral Glutamine in Neurologically-injured Patients Completed NCT00204971 Phase 4
49 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4 Caffeine citrate
50 Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure Completed NCT00447018 Phase 4 20% mannitol;7.45% hypertonic saline solution

Search NIH Clinical Center for Brain Injury

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Injury:
Hematopoietic stem cells for treatment of ischemic brain injury
Embryonic/Adult Cultured Cells Related to Brain Injury:
Bone marrow-derived hematopoietic stem cells (family)

Genetic Tests for Brain Injury

Anatomical Context for Brain Injury

MalaCards organs/tissues related to Brain Injury:

38
Brain, Testes, Bone, Heart, Eye, Spinal Cord, Cortex

Publications for Brain Injury

Articles related to Brain Injury:

(show top 50) (show all 2021)
# Title Authors Year
1
Injury of the Papez circuit in a patient with traumatic spinal cord injury and concomitant mild traumatic brain injury. ( 29451222 )
2018
2
Prevalence and association of oral candidiasis with dysphagia in individuals with acquired brain injury. ( 29182379 )
2018
3
Recovery of an injured corticofugal tract from the supplementary motor area in a patient with traumatic brain injury: A case report. ( 29443731 )
2018
4
Detecting Behavioral Deficits in Rats After Traumatic Brain Injury. ( 29443022 )
2018
5
Biomechanical simulation of traumatic brain injury in the rat. ( 29449041 )
2018
6
Clinical predictive score of intracranial hemorrhage in mild traumatic brain injury. ( 29440905 )
2018
7
Post-concussive symptoms after a mild traumatic brain injury during childhood and adolescence. ( 29446658 )
2018
8
Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice. ( 29439712 )
2018
9
Intravenous saline administration in patients with severe acquired brain injury and orthostatic intolerance for tilt-table mobilization. ( 29190150 )
2018
10
Continuous Remote Ischemic Conditioning Attenuates Cognitive and Motor Deficits From Moderate Traumatic Brain Injury. ( 29443855 )
2018
11
Barriers to Nutrition Intervention for Patients With a Traumatic Brain Injury: Views and Attitudes of Medical and Nursing Practitioners in the Acute Care Setting. ( 29443400 )
2018
12
Corrigendum: Image of the month: Dysphagia due to injury of the corticobulbar tract following traumatic brain injury. ( 29436459 )
2018
13
Mild traumatic brain injury: evaluation of olfactory dysfunction and clinical-neurological characteristics. ( 29446651 )
2018
14
Does Red Cell Distribution Width Predict Outcome in Traumatic Brain Injury: Comparison to Corticosteroid Randomization After Significant Head Injury. ( 29238428 )
2018
15
Utility of Retrograde Amnesia Assessment Alone, Compared with Anterograde Amnesia Assessment in Determining Recovery After Traumatic Brain Injury: Prospective Cohort Study. ( 29191531 )
2018
16
Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI). ( 29444081 )
2018
17
The Risk of Traumatic Brain Injury Occurring among Patients with Parkinson'sDisease: A 14-Year Population-Based Study. ( 29452320 )
2018
18
Management of traumatic brain injury patients. ( 29441170 )
2018
19
Over Resuscitation With Plasma is Associated With Sustained Fibrinolysis Shutdown and Death in Pediatric Traumatic Brain Injury. ( 29443859 )
2018
20
Atypical Within-Session Motor Procedural Learning after Traumatic Brain Injury but Well-Preserved Between-Session Procedural Memory Consolidation. ( 29441005 )
2018
21
Evidence- and Consensus-Based Guidelines for the Management of Communication and Swallowing Disorders Following Pediatric Traumatic Brain Injury. ( 29385009 )
2018
22
Hypopituitarism 3 and 12 months after traumatic brain injury and subarachnoid haemorrhage. ( 29283287 )
2018
23
Inhibition of HMGB1 mediates neuroprotection of traumatic brain injury by modulating the microglia/macrophage polarization. ( 29448108 )
2018
24
Impaired autophagic flux is associated with the severity of trauma and the role of A<sub>2A</sub>R in brain cells after traumatic brain injury. ( 29449536 )
2018
25
Decompressive craniectomy protects against hippocampal edema and behavioral deficits at an early stage of a moderately controlled cortical impact brain injury model in adult male rats. ( 29452194 )
2018
26
Erythropoietin Attenuates the Brain Edema Response after Experimental Traumatic Brain Injury. ( 29179621 )
2018
27
Histopathological and Behavioral Assessments of Aging Effects on Stem Cell Transplants in an Experimental Traumatic Brain Injury. ( 29445958 )
2018
28
Illness Severity Predicts Death and Brain Injury in Asphyxiated Newborns Treated with Hypothermia. ( 29452428 )
2018
29
Brain injury and neural stem cells. ( 29451199 )
2018
30
Neurometabolites Alteration in the Acute Phase of Mild Traumatic Brain Injury (mTBI): An In Vivo Proton Magnetic Resonance Spectroscopy (1H-MRS) Study. ( 29449141 )
2018
31
Endogenous Sex Steroids Dampen Neuroinflammation and Improve Outcome of Traumatic Brain Injury in Mice. ( 29450697 )
2018
32
Startle suppression after mild traumatic brain injury is associated with an increase in pro-inflammatory cytokines, reactive gliosis and neuronal loss in the caudal pontine reticular nucleus. ( 28089558 )
2017
33
Serum macrophage migration inhibitory factor concentrations correlate with prognosis of traumatic brain injury. ( 28366792 )
2017
34
Long term neurobehavioral symptoms and return to productivity in Operation Enduring Freedom/Operation Iraqi Freedom Veterans with and without traumatic brain injury. ( 28088381 )
2017
35
Prevalence of persistent vegetative state in patients with severe traumatic brain injury and its trend during the past four decades: A meta-analysis. ( 27814303 )
2017
36
Tau protein (MAPT) as a possible biochemical marker of traumatic brain injury in postmortem examination. ( 28942078 )
2017
37
Outcome prediction in traumatic brain injury: Is it a "Holy Grail?" ( 28084246 )
2017
38
Serum insulin-like growth factor-I levels are associated with improved white matter recovery after traumatic brain injury. ( 28574152 )
2017
39
The effect of concussion or mild traumatic brain injury on academic outcomes: A systematic review. ( 28084891 )
2017
40
Traumatic Brain Injury in Adolescents: Incidence and Correlates. ( 28942813 )
2017
41
Hyperostosis Frontalis Interna in a Child With Severe Traumatic Brain Injury. ( 28503629 )
2017
42
Functional outcome of critical illness polyneuropathy in patients affected by severe brain injury. ( 28417610 )
2017
43
Not every trauma patient with a radiographic head injury requires transfer for neurosurgical evaluation: Application of the brain injury guidelines to patients transferred to a level 1 trauma center. ( 28939250 )
2017
44
Paediatric traumatic brain injury: prognostic insights and outlooks. ( 28938340 )
2017
45
Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability and endothelial glycocalyx disruption following fluid-percussion brain injury in the rat. ( 28930945 )
2017
46
Transcranial ultrasound stimulation promotes brain-derived neurotrophic factor and reduces apoptosis in a mouse model of traumatic brain injury. ( 28939348 )
2017
47
Cocaine Abuse, Traumatic Brain Injury, and Preexisting Brain Lesions as Risk Factors for Bupropion-Associated Psychosis. ( 28590371 )
2017
48
Early neurological deterioration in older adults with traumatic brain injury. ( 28082072 )
2017
49
Validity of Accelerometry to Measure Physical Activity Intensity in Children With an Acquired Brain Injury. ( 28953176 )
2017
50
Epidemiology, Management, and Functional Outcomes of Traumatic Brain Injury in sub-Saharan Africa. ( 28943422 )
2017

Variations for Brain Injury

Expression for Brain Injury

Search GEO for disease gene expression data for Brain Injury.

Pathways for Brain Injury

GO Terms for Brain Injury

Cellular components related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.92 APOE ENO1 ENO2 EPO IGF1 IL10
2 myelin sheath GO:0043209 9.56 ENO2 GFAP MBP UCHL1
3 cell body GO:0044297 9.26 COMT EPO GFAP MAPT
4 phosphopyruvate hydratase complex GO:0000015 9.16 ENO1 ENO2
5 neuronal cell body GO:0043025 9.1 APOE ENO2 MAPT MBP S100B UCHL1

Biological processes related to Brain Injury according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.89 CASP3 EPO IGF1 IL10 IL6
2 response to lipopolysaccharide GO:0032496 9.67 CASP3 COMT EPO IL10
3 regulation of receptor activity GO:0010469 9.63 BDNF EPO IGF1 IL10 IL6 MAPT
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 EPO IGF1 IL6
5 dopamine metabolic process GO:0042417 9.51 COMT DRD2
6 long-term synaptic potentiation GO:0060291 9.5 GFAP S100B SLC24A2
7 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.48 IL10 MBP
8 axonal transport of mitochondrion GO:0019896 9.46 MAPT UCHL1
9 neuron projection regeneration GO:0031102 9.4 APOE GFAP
10 response to inactivity GO:0014854 9.26 DRD2 IL10
11 memory GO:0007613 9.26 ASIC1 MAPT S100B SLC24A2
12 response to glucocorticoid GO:0051384 8.92 CASP3 IL10 IL6 S100B

Molecular functions related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tau protein binding GO:0048156 9.32 APOE S100B
2 growth factor activity GO:0008083 9.26 BDNF IGF1 IL10 IL6
3 lipoprotein particle binding GO:0071813 9.16 APOE MAPT
4 phosphopyruvate hydratase activity GO:0004634 8.62 ENO1 ENO2
5 protein binding GO:0005515 10.19 APOE ASIC1 CASP3 COMT DRD2 ENO1

Sources for Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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