MCID: BRN071
MIFTS: 49

Brain Injury malady

Neuronal diseases category

Summaries for Brain Injury

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Wikipedia:63 A brain injury is any injury occurring in the brain of a living organism. Brain injuries can be... more...

MalaCards based summary: Brain Injury is related to cerebral hypoxia and dementia. An important gene associated with Brain Injury is SLC1A3 (solute carrier family 1 (glial high affinity glutamate transporter), member 3), and among its related pathways are Neurotransmitter uptake and Metabolism In Glial Cells and Glutamic acid signaling. The compounds dihydrokainate and doxycycline have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and pituitary, and related mouse phenotypes are liver/biliary system and vision/eye.

NINDS:42 Traumatic brain injury (TBI), a form of

Aliases & Classifications for Brain Injury

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Brain Injury, Aliases & Descriptions:

Name: Brain Injury 30 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Related Diseases for Brain Injury

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Diseases related to Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral hypoxia31.3NOS1
2dementia30.8APOE, APP
3brain ischemia30.6NOS1, APP, GDNF
4schizophrenia30.6SLC1A1, GDNF, SLC1A2, SLC1A3, NOS1
5ischemia30.4GDNF, HIF1A, PARP1, NOS1, SLC1A1, SLC1A3
6hemorrhage, intracerebral30.3APOE, APP
7cerebral amyloid angiopathy30.3APOE, APP
8epilepsy syndrome30.1NOS1, GDNF, SLC1A2, SLC1A1
9cerebrovascular disease30.0APOE, APP, ACE
10alzheimer disease29.8APOE, NOS1, APP, GDNF, SLC1A2, SLC1A3
11congenital heart disease29.8HIF1A, MMP9, ACE
12traumatic brain injury11.5
13cerebritis10.9
14hypopituitarism10.8
15neuronitis10.8
16brain edema10.8
17intracranial hypertension10.7
18hypoxia10.6
19head injury10.5
20dysautonomia10.5
21post-traumatic stress disorder10.5
22spasticity10.5
23aortic disease10.5APOE
24pyloric stenosis10.4NOS1
25cerebral artery occlusion10.4
26growth hormone deficiency10.4
27hypertonia10.4
28shaken baby syndrome10.4
29moderate and severe traumatic brain injury10.4
30hereditary cerebral amyloid angiopathy10.4APP
31diabetes insipidus10.4
32chorioamnionitis10.4
33inclusion body myositis10.4APP
34alexithymia10.4
35psychotic disorder10.4
36aneurysm10.4
37cerebral atrophy10.4
38endotheliitis10.4
39motor neuron disease10.3SLC1A2, SLC1A3, GDNF
40spinal cord injury10.3
41acute stress disorder10.3
42meningitis10.3
43post-traumatic epilepsy10.3
44binswanger's disease10.3APP, APOE
45status epilepticus10.3
46dysphagia10.3
47headache10.3
48alzheimer disease-210.3APOE, APP
49temporal lobe epilepsy10.2GDNF, SLC1A1, SLC1A2, SLC1A3
50pure autonomic failure10.2EPO, ACE

Graphical network of the top 20 diseases related to Brain Injury:



Diseases related to brain injury

Symptoms for Brain Injury

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Drugs & Therapeutics for Brain Injury

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Drug clinical trials:

Search ClinicalTrials for Brain Injury

Search NIH Clinical Center for Brain Injury

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Injury:
Hematopoietic stem cells for treatment of ischemic brain injury
Embryonic/Adult Cultured Cells Related to Brain Injury:
Bone marrow-derived hematopoietic stem cells (family)

Genetic Tests for Brain Injury

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Anatomical Context for Brain Injury

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MalaCards organs/tissues related to Brain Injury:

31
Brain, Bone, Pituitary, Cortex, Heart, Testes, Spinal cord, Endothelial, Eye, Prefrontal cortex, Neutrophil, Monocytes, Fetal brain, Bone marrow, Smooth muscle, Kidney, Liver, Lung, T cells, Thyroid, Myeloid, Hypothalamus, Medulla oblongata, Tongue

Animal Models for Brain Injury or affiliated genes

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Publications for Brain Injury

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Articles related to Brain Injury:

(show top 50)    (show all 1635)
idTitleAuthorsYear
1
Resveratrol Attenuates Early Brain Injury After Subarachnoid Hemorrhage Through Inhibition of NF-I_B-Dependent Inflammatory/MMP-9 Pathway. (24279692)
2014
2
Terson syndrome in subarachnoid hemorrhage, intracerebral hemorrhage, and traumatic brain injury. (25173620)
2014
3
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is neuroprotective in experimental traumatic brain injury. (24392832)
2014
4
Ischemic preconditioning attenuates brain injury induced by ischemia/reperfusion during moderate hypothermia low flow procedures. (24433123)
2014
5
Protective ventilation of preterm lambs exposed to acute chorioamnionitis does not reduce ventilation-induced lung or brain injury. (25379714)
2014
6
Discharge Planning Difficulties for Patients With Traumatic Brain Injury: Unique Funding Options. (24413072)
2014
7
Blood-brain barrier and traumatic brain injury. (24327344)
2014
8
Saccadic eye movements in mild traumatic brain injury: a pilot study. (24384339)
2014
9
Risk and Mortality of Traumatic Brain Injury in Stroke Patients: Two Nationwide Cohort Studies. (24263175)
2013
10
Cognitive Impairments Accompanying Rodent Mild Traumatic Brain Injury Involve p53-Dependent Neuronal Cell Death and Are Ameliorated by the Tetrahydrobenzothiazole PFT-I+. (24312187)
2013
11
Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham Study. (23929745)
2013
12
Cerebrospinal fluid brain injury biomarkers in children: a multicenter study. (23827424)
2013
13
Pulmonary thrombosis associated with antidiuretic hormone replacement therapy due to secondary diabetes insipidus after traumatic brain injury: A case report. (23131855)
2013
14
Increased expression of ferritin in cerebral cortex after human traumatic brain injury. (23079850)
2013
15
Effectiveness of melatonin for sleep impairment post paediatric acquired brain injury: Evidence from a systematic review. (24102301)
2013
16
Emerging pharmacological agents to improve survival from traumatic brain injury. (24205899)
2013
17
Anaesthesiologist-provided prehospital airway management in patients with traumatic brain injury: an observational study. (24368407)
2013
18
Neuroimaging, Behavioral, and Psychological Sequelae of Repetitive Combined Blast/Impact Mild Traumatic Brain Injury in Iraq and Afghanistan War Veterans. (24102309)
2013
19
Central diabetes insipidus in pediatric severe traumatic brain injury. (23314181)
2013
20
Optimization of the pattern visual evoked potential (VEP) in the visually-normal and mild traumatic brain injury (mTBI) populations. (24111626)
2013
21
Systemic Evaluation of Hypoxic-Ischemic Brain Injury in Neonatal Rats. (24323184)
2013
22
Quality of life after traumatic brain injury: Finnish experience of the QOLIBRI in residential rehabilitation. (24002322)
2013
23
Prediction of headache severity (density and functional impact) after traumatic brain injury: A longitudinal multicenter study. (23575819)
2013
24
The negative impact of traumatic brain injury (TBI) on bone in a mouse model. (24295038)
2013
25
Assessing Neuro-Systemic & Behavioral Components in the Pathophysiology of Blast-Related Brain Injury. (24312074)
2013
26
Tamoxifen as an effective neuroprotectant against early brain injury and learning deficits induced by subarachnoid hemorrhage: possible involvement of inflammatory signaling. (24373431)
2013
27
Impact of personal and environmental factors on employment outcome two years after moderate-to-severe traumatic brain injury. (24002317)
2013
28
Hypernatremia in patients with severe traumatic brain injury: a systematic review. (24196399)
2013
29
Dysautonomia after pediatric brain injury. (22712762)
2012
30
Human umbilical cord blood-derived mesenchymal stem cell transplantation attenuates severe brain injury by permanent middle cerebral artery occlusion in newborn rats. (22669296)
2012
31
Elevated plasma MCP-1 concentration following traumatic brain injury as a potential "predisposition" factor associated with an increased risk for subsequent development of Alzheimer's disease. (22543850)
2012
32
Response to intracranial hypertension treatment as a predictor of death in patients with severe traumatic brain injury. (21214327)
2011
33
Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study. (21646286)
2011
34
Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivative. (21552121)
2011
35
Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats. (21695352)
2011
36
Role of PPARs in Radiation-Induced Brain Injury. (19789638)
2010
37
Traumatic brain injury-related hypopituitarism: a review and recommendations for screening combat veterans. (20731261)
2010
38
Permanent central diabetes insipidus after mild traumatic brain injury. (19891534)
2009
39
Neuroprotection of GluR5-containing kainate receptor activation against ischemic brain injury through decreasing tyrosine phosphorylation of N-methyl-D-aspartate receptors mediated by Src kinase. (18678878)
2008
40
The pre-treatment effect on brain injury during restoration of normal perfusion pressure with hemodilution in a new rat model of chronic cerebral hypoperfusion. (17535558)
2007
41
Severe traumatic brain injury complicated by status asthmaticus: favorable neurological outcome despite excessive hypercapnia. (16612314)
2006
42
Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12-month study. (16144947)
2005
43
Hypopituitarism following traumatic brain injury (TBI): call for attention. (16114279)
2005
44
Lesional expression of RhoA and RhoB following traumatic brain injury in humans. (15253798)
2004
45
Research on prevention of bilirubin-induced brain injury and kernicterus: National Institute of Child Health and Human Development conference executive summary. 2003. (15231933)
2004
46
Poly(adenosine diphosphate-ribose) polymerase expression in human traumatic brain injury. (12854754)
2003
47
Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans. (11777556)
2002
48
Relationship between acute stress disorder and posttraumatic stress disorder following mild traumatic brain injury. (9585713)
1998
49
Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. (9257663)
1997
50
Signal cascade of NGF and its application in the treatment of brain injury and neural tumor]. (8372235)
1993

Variations for Brain Injury

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Expression for genes affiliated with Brain Injury

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Search GEO for disease gene expression data for Brain Injury.

Pathways for genes affiliated with Brain Injury

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Pathways related to Brain Injury according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1SLC1A2, SLC1A3
2
Show member pathways
9.8EPO, HIF1A
3
Show member pathways
Angiogenesis36
9.6MMP9, HIF1A
49.6SLC1A3, IL1RN, HIF1A
5
Show member pathways
Alzheimers Disease36
9.5APOE, APP, NOS1
6
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
9.5SLC1A2, SLC1A3, SLC1A1, NOS1
79.4GDNF, MMP9, NOS1
89.1ACE, MMP9, APP
98.9APOE, APP, NOS1, SLC1A1, SLC1A3, SLC1A2
108.9APOE, APP, MMP9, ACE
11
Show member pathways
8.8SLC1A1, SLC1A7, SLC1A6
128.8NOS1, PARP1, APP, APOE, HIF1A
13
Show member pathways
8.4SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
14
Show member pathways
8.2SLC1A1, SLC1A7, SLC1A3, SLC24A2, SLC1A6, SLC1A2
15
Show member pathways
7.7SLC1A2, APP, NOS1, SLC1A1, SLC1A7, SLC1A3

Compounds for genes affiliated with Brain Injury

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Compounds related to Brain Injury according to GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1dihydrokainate43 2811.2SLC1A2, SLC1A1, SLC1A3
2doxycycline43 1210.3MMP9, HIF1A, GDNF, EPO
3ns 39843 5910.3PARP1, MMP9, IL1RN, HIF1A
4l-nmma439.3NOS1, IL1RN, MMP9, HIF1A
5glutamine439.2APP, NOS1, SLC1A3, SLC1A1, SLC1A2, APOE
6kainate43 2810.2GDNF, SLC1A2, SLC1A1, IL1RN, SLC1A3, EPO
7folate439.1MMP9, EPO, APP, APOE, NOS1
8celecoxib43 59 28 49 24 1214.1MMP9, HIF1A, EPO, PARP1
9pdtc439.0PARP1, HIF1A, MMP9, NOS1
10nicotine43 28 49 1212.0HIF1A, APOE, MMP9, NOS1, APP
11superoxide43 249.9SLC1A3, NOS1, IL1RN, SLC1A2, HIF1A, GDNF
12aspirin43 49 28 2411.9CYSLTR1, APOE, APP, IL1RN, ACE
13iron43 249.9APP, IL1RN, SLC1A2, EPO, HIF1A, GDNF
14way 213613598.9SLC1A7, SLC1A1, SLC1A3, SLC1A6, SLC1A2
15dihydrokainic acid598.8SLC1A1, SLC1A3, SLC1A6, SLC1A2, SLC1A7
16dl-tboa59 289.8SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
17tfb-tboa598.8SLC1A2, SLC1A6, SLC1A3, SLC1A1, SLC1A7
18l-trans-2,4-pdc598.8SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
19[3h]d-aspartic acid288.8SLC1A1, SLC1A2, SLC1A6, SLC1A3, SLC1A7
20gaba438.8SLC1A2, SLC1A1, NOS1, MMP9, SLC1A3, APP
21[3h]etb-tboa288.8SLC1A2, SLC1A3, SLC1A7, SLC1A1, SLC1A6
22[3h]l-aspartic acid288.8SLC1A2, SLC1A3, SLC1A7, SLC1A1, SLC1A6
23l-glutamic acid28 24 1210.8SLC1A1, SLC1A7, SLC1A2, SLC1A6, SLC1A3
24lactacystin438.7HIF1A, PARP1, NOS1, APOE, APP, MMP9
25methotrexate49 43 1210.7HIF1A, MMP9, IL1RN, NOS1, EPO, APP
26actinomycin d438.7APP, HIF1A, GDNF, APOE, MMP9, PARP1
27adenylate438.7IL1RN, MMP9, SLC1A2, APP, SLC1A3, GDNF
28sb 20358043 599.6HIF1A, PARP1, MMP9, IL1RN, NOS1
29chloride438.6SLC1A7, SLC1A2, SLC1A6, SLC1A3, SLC1A1
30ascorbic acid43 249.6HIF1A, NOS1, IL1RN, EPO, APOE
31dopamine43 28 24 1211.6APP, GDNF, HIF1A, APOE, MMP9, NOS1
32cyclosporin a43 28 5910.5HIF1A, APP, EPO, APOE, IL1RN, NOS1
33nitric oxide43 24 1210.4HIF1A, SLC1A2, SLC1A3, NOS1, IL1RN, ACE
34phosphatidylinositol438.4CYSLTR1, GDNF, EPO, MMP9, IL1RN, SLC1A1
35norepinephrine43 24 1210.4IL1RN, SLC1A2, ACE, MMP9, APP, GDNF
36testosterone43 59 24 1211.4APOE, NOS1, HIF1A, IL1RN, MMP9, EPO
37cycloheximide438.4APOE, MMP9, PARP1, IL1RN, NOS1, HIF1A
38h2o2438.4APP, SLC1A2, NOS1, IL1RN, PARP1, APOE
39oxygen43 249.2IL1RN, HIF1A, EPO, GDNF, NOS1, PARP1
40dexamethasone43 49 28 1211.1NOS1, IL1RN, MMP9, PARP1, APP, HIF1A
41retinoic acid43 249.1APP, NOS1, IL1RN, SLC1A1, MMP9, PARP1
42creatinine438.1MMP9, EPO, ACE, IL1RN, NOS1, GDNF
43nmda43 288.9IL1RN, NOS1, SLC1A1, APP, SLC1A3, SLC1A2
44alanine437.9IL1RN, SLC1A1, SLC1A2, SLC1A3, NOS1, MMP9
45vegf437.9GDNF, APOE, APP, PARP1, EPO, MMP9
46serine437.8NOS1, SLC1A2, SLC1A3, GDNF, HIF1A, APOE
47sodium43 248.8ACE, GDNF, SLC1A1, SLC1A7, SLC1A3, SLC24A2
48aspartate437.7SLC1A2, SLC1A6, SLC1A3, SLC1A1, MMP9, APOE
49cysteine437.3MMP9, PARP1, SLC1A1, NOS1, IL1RN, SLC24A2
50glutamate436.9SLC1A1, IL1RN, APP, MMP9, NOS1, APOE

GO Terms for genes affiliated with Brain Injury

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Cellular components related to Brain Injury according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:00160208.9CYSLTR1, SLC1A1, SLC1A3, SLC1A6, SLC1A2
2extracellular spaceGO:00056158.7IL1RN, ACE, MMP9, EPO, APOE
3extracellular regionGO:00055768.0GDNF, APOE, APP, EPO, MMP9, ACE
4plasma membraneGO:00058866.5SLC1A2, CYSLTR1, APOE, APP, ACE, IL1RN

Biological processes related to Brain Injury according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1D-aspartate importGO:007077910.1SLC1A2, SLC1A3, SLC1A1
2L-glutamate importGO:005193810.1SLC1A1, SLC1A3, SLC1A2
3negative regulation of calcium ion transport into cytosolGO:001052310.1NOS1, EPO
4hemoglobin biosynthetic processGO:004254110.0EPO, HIF1A
5positive regulation of nitric-oxide synthase activityGO:00510009.9HIF1A, APOE
6regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:00614189.8EPO, HIF1A
7macrophage differentiationGO:00302259.7PARP1, MMP9
8nitric oxide mediated signal transductionGO:00072639.6NOS1, APOE
9negative regulation of neuron apoptotic processGO:00435249.6GDNF, HIF1A, APOE
10L-glutamate transportGO:00158139.2SLC1A7, SLC1A6
11synaptic transmissionGO:00072689.1SLC1A1, SLC1A3, SLC1A6, SLC1A2
12positive regulation of transcription from RNA polymerase II promoterGO:00459448.9NOS1, PARP1, APP, HIF1A, GDNF
13ion transportGO:00068118.4SLC1A2, SLC1A1, SLC1A7, SLC1A3, SLC24A2, SLC1A6
14transmembrane transportGO:00550858.4SLC1A1, SLC1A7, SLC1A3, SLC24A2, SLC1A6, SLC1A2

Molecular functions related to Brain Injury according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutamate:sodium symporter activityGO:001550110.0SLC1A1, SLC1A2
2cadmium ion bindingGO:00468709.8SLC24A2, NOS1
3glutamate bindingGO:00165959.8SLC1A3, SLC1A1
4identical protein bindingGO:00428029.1MMP9, PARP1, APP, APOE
5sodium:dicarboxylate symporter activityGO:00171538.5SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
6L-glutamate transmembrane transporter activityGO:00053138.5SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2

Products for genes affiliated with Brain Injury

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Sources for Brain Injury

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet