MCID: BRN080
MIFTS: 51

Brain Ischemia malady

Neuronal diseases category
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Summaries for Brain Ischemia

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Wikipedia:65 Brain ischemia (aka cerebral ischemia, cerebrovascular ischemia) is a condition in which there is... more...

MalaCards based summary: Brain Ischemia is related to ischemia and alzheimer's disease. An important gene associated with Brain Ischemia is NES (nestin), and among its related pathways are Nucleotide-like (purinergic) receptors and Arginine and proline metabolism. The drugs papaverine and papaverine hydrochloride and the compounds cp608,039 and peneca have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and monocytes, and related mouse phenotypes are no phenotypic analysis and renal/urinary system.

Aliases & Classifications for Brain Ischemia

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Brain Ischemia, Aliases & Descriptions:

Name: Brain Ischemia 30 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Related Diseases for Brain Ischemia

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Diseases related to Brain Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.3NOS1, EIF2AK3, CKB, MAP2, ADORA1, ADORA3
2alzheimer's disease29.4ADORA1, CKB, CAMK2G, MAP2, NOS1, GDNF
3schizophrenia29.3ADCY10, NOS1, MAP2, GDNF
4neuronitis10.8
5cerebritis10.7
6hypoxia10.5
7brain injury10.4
8ganglioglioma10.3MAP2
9cerebral artery occlusion10.3
10pyloric stenosis10.2NOS1
11hyperglycemia10.2
12endotheliitis10.2
13hypertension10.1
14traumatic brain injury10.1
15angioedema10.1
16protein-energy malnutrition10.1
17stroke, ischemic10.1GDNF, NES
18ependymoma10.1NES, MAP2
19congenital heart disease10.1ADCY10, CKB
20multiple system atrophy10.1MAP2, GDNF
21tuberous sclerosis10.1NES, MAP2
22pituitary adenoma10.1GDNF, ADCY10, NES
23temporal lobe epilepsy10.1GDNF, ADORA1, CAMK2G
24hirschsprung's disease10.0NOS1, GDNF
25transient cerebral ischemia10.0ADORA1, MAP2, CAMK2G
26atherosclerosis10.0
27hepatitis10.0
28hyperhomocysteinemia10.0
29hypoglycemia10.0
30vascular dementia10.0
31brain edema10.0
32artery disease10.0
33carotid artery disease10.0
34dementia10.0
35ehlers-danlos syndrome10.0
36herpes simplex10.0
37mitochondrial cardiomyopathy10.0
38aneurysm10.0
39anoxia10.0
40myoclonus10.0
41memory impairment10.0
42brain cancer10.0GDNF, MAP2, NES
43cystic fibrosis10.0ADORA1, CAMK2G, ADCY10
44toxic encephalopathy10.0GDNF, MAP2
45duchenne muscular dystrophy9.9GDNF, NOS1
46pheochromocytoma9.9GDNF, MAP2, ADCY10
47factor v leiden thrombophilia9.9ADCY10, NOS1, NES
48vascular disease9.8ADORA1, NOS1, MAP2
49bipolar disorder9.8GDNF, MAP2, NOS1
50lung small cell carcinoma9.8CKB, MAP2, GDNF, ADCY10

Graphical network of the top 20 diseases related to Brain Ischemia:



Diseases related to brain ischemia

Symptoms for Brain Ischemia

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Drugs & Therapeutics for Brain Ischemia

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Drug clinical trials:

Search ClinicalTrials for Brain Ischemia

Search NIH Clinical Center for Brain Ischemia

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Brain Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Ischemia:
Mesenchymal stem cell-derived neuronal progenitor cells for the treatment of ischemic brain damage
Embryonic/Adult Cultured Cells Related to Brain Ischemia:
Neural progenitor cells, PMID: 21300404

Genetic Tests for Brain Ischemia

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Anatomical Context for Brain Ischemia

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MalaCards organs/tissues related to Brain Ischemia:

32
Brain, Cortex, Monocytes, Endothelial, Bone marrow, Bone, Neutrophil, Heart, Liver, Prefrontal cortex, Pituitary

Animal Models for Brain Ischemia or affiliated genes

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MGI Mouse Phenotypes related to Brain Ischemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4NOS1, EIF2AK3, CAMK2G, ADORA3
2MP:00053678.2GDNF, ADORA3, ADORA1, NOS1
3MP:00053857.9ADORA1, ADORA3, ADCY10, NOS1, GDNF
4MP:00053897.6ADCY10, GDNF, MAP2, CAMK2G, NOS1
5MP:00053787.6NOS1, GDNF, EIF2AK3, CKB, MAP2, NES
6MP:00053767.5NOS1, CAMK2G, ADCY10, ADORA1, EIF2AK3, ADORA3
7MP:00036317.3NOS1, EIF2AK3, CKB, MAP2, ADORA1, NES
8MP:00053867.0ADORA3, EIF2AK3, CKB, MAP2, ADORA1, NES

Publications for Brain Ischemia

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Articles related to Brain Ischemia:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Onset of Orolingual Angioedema After Treatment of Acute Brain Ischemia with Alteplase Depends on the Site of Brain Ischemia: A Meta-analysis. (24350070)
2013
2
Effects of vinpocetine and ozagrel on behavioral recovery of rats after global brain ischemia. (24291485)
2013
3
Phosphorylation of tau protein over time in rats subjected to transient brain ischemia. (25206638)
2013
4
Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neurons. (23355003)
2013
5
Protein misfolding, aggregation, and autophagy after brain ischemia. (24323413)
2013
6
DCX-expressing neurons decrease in the retrosplenial cortex after global brain ischemia. (22879023)
2013
7
Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction. (22158864)
2012
8
Eag1, Eag2, and SK3 potassium channel expression in the rat hippocampus after global transient brain ischemia. (22006722)
2012
9
Texture analysis of poly-adenylated mRNA staining following global brain ischemia and reperfusion. (21477879)
2012
10
Phenolic alkaloids from Menispermum dauricum rhizome protect against brain ischemia injury via regulation of GLT-1, EAAC1 and ROS generation. (22395403)
2012
11
E-selectin deficiency attenuates brain ischemia in mice. (22978829)
2012
12
Brain ischemia, neurogenesis, and neurotrophic receptor expression in primates. (21701994)
2011
13
'Functional histology' in brain ischemia studies. (21448216)
2011
14
Zinc: new clues to diverse roles in brain ischemia. (21621864)
2011
15
The protective effect of avocado soybean unsaponifilables on brain ischemia/reperfusion injury in rat prefrontal cortex. (20874457)
2011
16
Brain ischemia and hypometabolism treated by ozone therapy. (22105041)
2011
17
The effects of voluntary, involuntary, and forced exercises on brain-derived neurotrophic factor and motor function recovery: a rat brain ischemia model. (21347437)
2011
18
Transient middle cerebral artery occlusion in rats as an experimental model of brain ischemia. (20877953)
2010
19
Antioxidant CR-6 protects against reperfusion injury after a transient episode of focal brain ischemia in rats. (19904289)
2010
20
Study of the origin of short- and long-latency SSEP during recovery from brain ischemia in a rat model. (20816917)
2010
21
Fate and manipulations of endogenous neural stem cells following brain ischemia. (19653861)
2009
22
Reduction of brain infarction induced by a transient brain ischemia in mdr1a knockout mice. (19277863)
2009
23
PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia. (19384589)
2009
24
Association of protein kinase C delta and phospholipid scramblase 3 in hippocampal mitochondria correlates with neuronal vulnerability to brain ischemia. (19428821)
2009
25
Topiramate reduces non-convulsive seizures after focal brain ischemia in the rat. (18063309)
2008
26
Temporal changes in free iron levels after brain ischemia Relevance to the timing of iron chelation therapy in stroke. (18485533)
2008
27
Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions. (17157267)
2007
28
Differential changes in phosphorylation of tau at PHF-1 and 12E8 epitopes during brain ischemia and reperfusion in gerbils. (17191139)
2007
29
Rasagiline is neuroprotective in an experimental model of brain ischemia in the rat. (17177075)
2007
30
Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemia. (16498189)
2006
31
Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. (15686962)
2005
32
Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia. (15684564)
2005
33
Pathophysiology of brain ischemia: penumbra, gene expression, and future therapeutic options. (16352903)
2005
34
C1-inhibitor protects against brain ischemia-reperfusion injury via inhibition of cell recruitment and inflammation. (15837556)
2005
35
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study. (15716852)
2005
36
Manganese-enhanced magnetic resonance imaging (MEMRI) of brain activity and applications to early detection of brain ischemia. (15617055)
2004
37
An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia. (15489015)
2004
38
Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. (15161641)
2004
39
Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm. (14969736)
2004
40
Two types of calcium channels regulating activation of proline-rich tyrosine kinase 2 induced by transient brain ischemia in rat hippocampus. (12932810)
2003
41
Cooling and rewarming for brain ischemia or injury: theoretical analysis. (12680732)
2003
42
Modulation of IkappaB kinase autophosphorylation and activity following brain ischemia. (12676069)
2003
43
Subcellular localization of a promoter and an inhibitor of apoptosis (Smac/DIABLO and XIAP) during brain ischemia/reperfusion. (12395105)
2002
44
Perfusion mapping using computed tomography allows accurate prediction of cerebral infarction in experimental brain ischemia. (11136934)
2001
45
Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin. (11166685)
2001
46
Effect of carnosine on rats under experimental brain ischemia. (10946918)
2000
47
Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis. (11105983)
2000
48
Brain metabolic and ionic responses to global brain ischemia in the newborn dog in vivo: 1. Methodological aspects. (10935225)
2000
49
Metabolic and ionic responses to global brain ischemia in the newborn dog in vivo: II. Post-natal age aspects. (11045028)
2000
50
Potential role of calcineurin for brain ischemia and traumatic injury. (10321795)
1999

Variations for Brain Ischemia

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Expression for genes affiliated with Brain Ischemia

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Expression patterns in normal tissues for genes affiliated with Brain Ischemia

Search GEO for disease gene expression data for Brain Ischemia.

Pathways for genes affiliated with Brain Ischemia

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Pathways related to Brain Ischemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8ADORA3, ADORA1
2
Show member pathways
citrulline-nitric oxide cycle37
arginine degradation I (arginase pathway)37
proline degradation37
glutamine degradation I37
proline biosynthesis I37
superpathway of citrulline metabolism37
proline biosynthesis II (from arginine)37
citrulline biosynthesis37
arginine degradation VI (arginase 2 pathway)37
Urea cycle and metabolism of amino groups37
asparagine biosynthesis I37
4-hydroxyproline degradation I37
citrulline degradation37
9.3NOS1, CKB
38.5NOS1, CAMK2G, MAP2
4
Show member pathways
8.3NOS1, CAMK2G, ADCY10, ADORA1

Compounds for genes affiliated with Brain Ischemia

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Compounds related to Brain Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1cp608,0392810.1ADORA3, ADORA1
2peneca2810.1ADORA3, ADORA1
3apadenoson2810.1ADORA1, ADORA3
4psb-112810.1ADORA1, ADORA3
5psb-102810.1ADORA3, ADORA1
6mrs51512810.1ADORA1, ADORA3
7psb11152810.1ADORA3, ADORA1
8(r,s)-phpneca2810.1ADORA1, ADORA3
92-hexynyl-neca2810.0ADORA1, ADORA3
10gs96672810.0ADORA1, ADORA3
11bay60-65832810.0ADORA1, ADORA3
12regadenoson44 28 1111.9ADORA1, ADORA3
13neca289.9ADORA3, ADORA1
14binodenoson44 2810.8ADORA3, ADORA1
15las38096289.8ADORA1, ADORA3
16atl802289.7ADORA1, ADORA3
17(r)-(phenylisopropyl)adenosine449.7ADCY10, ADORA3, ADORA1
185-n-ethylcarboxamidoadenosine449.7ADORA3, ADORA1, ADCY10
19cyclopentyladenosine289.5ADORA1, ADORA3
20ganglioside449.0GDNF, NES, MAP2, CAMK2G
21kainate44 289.7GDNF, ADORA1, NES, MAP2, CAMK2G
22carbachol44 28 1110.7NOS1, ADORA1, ADCY10, CAMK2G
235-hydroxytryptamine448.6ADORA1, ADCY10, NOS1, CAMK2G
24forskolin44 50 1110.6GDNF, CKB, CAMK2G, ADCY10, ADORA3
25isoproterenol44 119.6ADORA1, ADCY10, CAMK2G, NOS1
26aspartate448.4GDNF, ADORA1, CKB, EIF2AK3, NOS1
27genistein44 28 61 2 24 1113.4GDNF, ADCY10, ADORA3, NOS1, ADORA1
28histamine44 28 2410.3CAMK2G, NOS1, ADCY10, ADORA1, ADORA3
29potassium44 24 1110.3CAMK2G, GDNF, MAP2, ADORA1, ADORA3, CKB
30choline44 24 1110.2GDNF, MAP2, NES, NOS1, CAMK2G
31cocaine44 119.1NOS1, CAMK2G, MAP2, ADORA1, GDNF
32nmda44 289.1CAMK2G, NOS1, ADORA1, GDNF, MAP2
33phosphoinositide448.1ADCY10, MAP2, CAMK2G, ADORA1, ADORA3, GDNF
34dexamethasone44 50 28 1111.1NOS1, ADCY10, ADORA1, GDNF, CAMK2G
35superoxide44 249.1ADORA3, MAP2, CAMK2G, NOS1, GDNF
36vegf448.0NOS1, GDNF, NES, CAMK2G, MAP2
37acetylcholine44 50 28 24 1112.0ADCY10, ADORA1, NES, GDNF, CAMK2G, NOS1
38alanine447.9NOS1, EIF2AK3, CKB, ADORA1, GDNF, CAMK2G
39nitric oxide44 24 119.9MAP2, ADORA3, NES, EIF2AK3, NOS1, GDNF
40glucose447.9EIF2AK3, CAMK2G, ADORA3, NES, GDNF, CKB
41atp44 288.8ADORA3, ADORA1, CAMK2G, MAP2, GDNF, CKB
42cyclic amp44 248.8ADCY10, GDNF, ADORA3, ADORA1, MAP2, CKB
43norepinephrine44 24 119.6NOS1, MAP2, GDNF, ADORA1, ADCY10, CAMK2G
44gaba447.5ADORA1, GDNF, MAP2, CAMK2G, NOS1, NES
45dopamine44 28 24 1110.4ADCY10, NES, GDNF, MAP2, CAMK2G, NOS1
46adenylate447.3ADORA3, MAP2, CAMK2G, NOS1, ADCY10, ADORA1
47estrogen447.3CKB, EIF2AK3, MAP2, ADORA1, ADORA3, NES
48oxygen44 248.1GDNF, CKB, CAMK2G, MAP2, ADORA3, EIF2AK3
49glutamate447.0ADORA1, GDNF, ADCY10, MAP2, CAMK2G, NES
50calcium44 50 24 119.5CAMK2G, ADORA3, GDNF, MAP2, ADCY10, ADORA1

GO Terms for genes affiliated with Brain Ischemia

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Cellular components related to Brain Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.0MAP2, ADCY10, ADORA1

Biological processes related to Brain Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin secretionGO:0300739.2EIF2AK3, CAMK2G
2negative regulation of blood pressureGO:0457769.2NOS1, ADORA1
3nervous system developmentGO:0073999.2CAMK2G, ADORA1, GDNF

Molecular functions related to Brain Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled adenosine receptor activityGO:0016099.5ADORA1, ADORA3
2calmodulin bindingGO:0055168.5NOS1, CAMK2G, MAP2

Products for genes affiliated with Brain Ischemia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Brain Ischemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet