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MCID: BRN080

Brain Ischemia malady
4 drugs, 95 genes, 4 tissues, 481 related diseases, 20 phenotypes, 56 articles, clinical trials.

Summaries for Brain Ischemia

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44Wikipedia, 22MalaCards
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Wikipedia: Brain ischemia, also known as cerebral ischemia, is a condition in which there is insufficient blood...44 more...

MalaCards: Brain Ischemia is related to memory impairment and myoclonus. An important gene associated with Brain Ischemia is CKB (creatine kinase, brain), and among its related pathways are Development Leptin signaling via JAK/STAT and MAPK cascades and Development_Leptin signaling via JAK/STAT and MAPK cascades. The drugs papaverine and pentoxifylline and the compounds carbachol and manumycin have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Aliases & Descriptions for Brain Ischemia

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8DISEASES, 32Novoseek , 43UMLS
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brain ischemia 8 32 43

Related Diseases for Brain Ischemia

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13GeneCards, 14GeneDecks
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Diseases related to brain ischemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 478)
idRelated DiseaseScoreTop Affiliating Genes
1memory impairment29.1BDNF, APP, MAPT, ADORA1, GAP43
2myoclonus28.9CDKN3, ALDOA, DUSP19, CTSB, ACP1, GFAP
3hyperglycemia23.7SELP, VEGFA, PARP1, BDNF, P4HB, XBP1
4ischemia20.9SELP, VIP, VEGFA, LPHN1, LPHN3, CLDN5
5cerebritis17.7SELP, VIP, VEGFA, CLDN5, PARP1, BDNF
6neuronitis16.9RBFOX3, SELP, VIP, VEGFA, LPHN1, LPHN3
7hypoxia16.9SELP, VIP, VEGFA, PARP1, BDNF, KCNB1
8basilar artery occlusion13.9CAMK2G, DYT10, PLAT
9binswanger's disease13.7APP, MAPT, GFAP
10creutzfeldt-jakob syndrome13.7APP, MAPT, RPS27A, NES
11glucagonoma13.7VIP, SCG5, DYT10, ADCY10
12heterotopia13.6VIP, MAP2, DCX, ADCYAP1
13olivopontocerebellar atrophy13.6MAPT, MAP2, DYT10, RPS27A
14trigonitis13.6CDKN3, MAPK10, DYT10, NOS2
15impotence13.6VIP, DYT10, NOS1, KNG1
16achalasia13.6VIP, NOS1, NOS2, NOS3, GDNF
17tauopathy13.6CDKN3, APP, MAPT, CAMK2G, RPS27A
18hirschsprung's disease13.6VIP, NOS1, ADCYAP1, GDNF
19cerebral amyloid angiopathy13.6AQP4, APP, MAPT, PLAT, RPS27A
20inclusion body myositis13.6APP, MAPT, RPS27A
21spinal cord ischemia13.6CASP3, NOS3, GDNF
22duchenne muscular dystrophy13.5CKB, AQP4, HLA-A, CTSB, NOS1, ADA
23amyloid tumor13.5APP, MAPT, CTSB, RPS27A
24familial medullary thyroid carcinoma13.5FOS, MAPK3, GDNF
25cerebral aneurysms13.5SELP, CTSB, PLAT, NOS2, NOS3
26pulmonary hypertension13.5VIP, NOS2, NOS3, ADCY10, ADCYAP1
27bipolar affective disorder13.5BDNF, DYT10, NOS1, ADCY10, ADORA1, ADCYAP1
28central nervous system disease13.5BDNF, CKB, APP, MAPT, GFAP
29multiple endocrine neoplasia13.5VIP, HSPA4, HSPA8, CAPN1, EGR1, GDNF
30neuroma13.4PARP1, AQP4, MAPK10, GFAP, GAP43, GDNF
31gliosarcoma13.4MSI1, CDKN3, GJA1, GFAP
32mood disorder13.4BDNF, XBP1, GRIN2A, MAP2, NOS1, NOS3
33temporal lobe epilepsy13.4BDNF, AQP4, CAMK2G, GJA1, GFAP, ADORA1
34normal pressure hydrocephalus13.4VIP, BDNF, MAPT, GFAP
35hemorrhagic shock and encephalopathy syndrome13.4XDH, NOS2, NOS3
36cluster headache13.4VIP, NOS1, NOS2, NOS3
37pediatric cns embryonal cell carcinoma13.3FOS, APP, CASP9, DUSP19, EGR1, NES
38central neurocytoma13.3RBFOX3, MAP2, GFAP, NES
39alpha 1-antitrypsin deficiency13.3CKB, MAP2, CYCS, RYR2
40aphasia13.3APP, MAPT, PLAT, RPS27A
41tourette syndrome13.3BDNF, ITGA1, HMGCR, ACP1, ADCY10, GDNF
42beriberi13.3VEGFA, APP, EIF2S1, GFAP
43central pontine myelinolysis13.3BDNF, AQP4, APP, HSPA8, NOS2, GFAP
44cerebral primitive neuroectodermal tumor13.2VIP, MAPK3, MAPK10, CASP3, GFAP, NES
45brain malformations13.2MAP2, TUBB3, DCX, SOD1
46periventricular leukomalacia13.2VEGFA, APP, NOS2, NES
47leukomalacia13.2VEGFA, APP, NOS2, NES
48cerebral hypoxia13.2FOS, APP, CASP3, CASP9, PLAT, NOS1
49neuroepithelioma13.2MAPK10, MAPK1, CASP3, DYT10, DUSP19, NOS1
50was-related disorders13.2BDNF, XDH, AQP4, APP, MAPT, PLAT

Graphical network of the top 20 diseases related to brain ischemia:



Graphical network of diseases related to brain ischemia

Clinical Features for Brain Ischemia

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Drugs & Therapeutics for Brain Ischemia

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for brain ischemia

Drug clinical trials:

Search ClinicalTrials for brain ischemia

Search NIH Clinical Center for brain ischemia

Search CenterWatch for brain ischemia

Inferred drug relations via UMLS/NDF-RT:

43 28 etomidate, papaverine, papaverine hydrochloride, pentoxifylline

Genetic Tests for Brain Ischemia

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Anatomical Context for Brain Ischemia

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22MalaCards
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MalaCards organs/tissues related to brain ischemia:

22
Brain, Cortex, Heart, Endothelial

Phenotypes for genes affiliated with Brain Ischemia

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25MGI
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MGI Mouse Phenotypes related to brain ischemia:

25 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:000537910.2SCG5, APAF1, GJA1, XDH
2hematopoietic system phenotypeMP:00053979.8CASP9, GDNF, ADA, TGM2, EIF2S1, XBP1
3respiratory system phenotypeMP:00053889.8SELP, ADORA1, NOS1, AQP4, SCG5, ADORA3
4other phenotypeMP:00053959.7NOS2, NOS1, CTSB, GJA1, MAPT, APP
5renal/urinary system phenotypeMP:00053679.5PRKCD, ADORA1, TGM2, NOS3, CTSB, CASP3
6liver/biliary system phenotypeMP:00053709.1ADCYAP1, SOD1, EGR1, NOS3, XBP1, SCG5
7taste/olfaction phenotypeMP:00053948.9CASP3, CASP9, MAPK1, MAPT, FYN, BDNF
8skeleton phenotypeMP:00053907.7PRKCD, CASP3, EIF2AK3, EGR1, NOS1, PLAT
9integument phenotypeMP:00107717.5CAMK2A, DLG4, SRC, CTSB, ADORA3, ADORA1
10reproductive system phenotypeMP:00053897.4SRC, VIP, VEGFA, FOS, APAF1, APP
11immune system phenotypeMP:00053877.0FOS, APAF1, MAPT, MAP3K11, CCL3, CAPN1
12muscle phenotypeMP:00053697.0PTK2B, GJA1, MAPK1, MAPT, APP, XBP1
13vision/eye phenotypeMP:00053916.4PLAT, SELP, VEGFA, BDNF, FYN, FOS
14cardiovascular system phenotypeMP:00053856.1CAPN1, MSI1, AQP4, ADORA3, GDNF, APAF1
15mortality/agingMP:00107686.1RYR2, NES, ADA, ADCYAP1, GAP43, GDNF
16nervous system phenotypeMP:00036315.6RYR2, APAF1, AQP4, GRIN2A, FOS, FYN
17behavior/neurological phenotypeMP:00053865.0SCG5, MAP2, MAPK3, MAPK10, MAPK1, CCL3
18growth/size phenotypeMP:00053785.0GDNF, GAP43, ADCYAP1, ADA, RYR2, CASP3
19cellular phenotypeMP:00053843.8SELP, VEGFA, PARP1, BDNF, MT-CO1, XDH
20homeostasis/metabolism phenotypeMP:00053763.4ADORA3, ADCYAP1, ADA, PTK2B, GJA1, CAMK2G

Publications for genes affiliated with Brain Ischemia

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35PubMed
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Articles related to brain ischemia:

(show top 50)    (show all 56)
idTitleAuthorsYearAffiliating Genes
1Optimal dose of plasmid vascular endothelial growth f actor for enhancement of angiogenesis in the rat brain ischemia model. (20587967)Katsumata A.... Date I.2010VEGFA
2Musashi1 as a marker of reactive astrocytes after tra nsient focal brain ischemia. (20036290)Oki K.... Okano H.2010MSI1, NES
3Association of protein kinase C delta and phospholipid scramblase 3 in hippocampal mitochondria correlates with neuronal vulnerability to brain ischemia. (19428821)Kowalczyk J.E.... ZabA8ocka B.2009PRKCD, PLSCR3
4Role of Akt and ERK signaling in the neurogenesis fol lowing brain ischemia. (19607982)Shioda N.... Fukunaga K.2009MAPK1
517beta-estradiol and enriched environment accelerate cognitive recovery after focal brain ischemia. (19302156)SAPderstrAPm I.... Olsson T.2009EGR1
6The neuroprotective effect of PACAP, VIP, and derivatives in brain ischemia (18806737)JA^A_wiak-Bebenista M.... Nowak J.Z.2008VIP, ADCYAP1
7Transient brain ischemia: NMDA receptor modulation and delayed neuronal death (18272081)Benquet P.... Gerber U.2008CDKN3
8Dynamic regulation of the Kv2.1 voltage-gated potassium channel during brain ischemia through neuroglial interaction. (18716211)Misonou H.... Cai X.2008KCNB1
9Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment. (17689202)Huang D.... Yu B.2008KCNK10
10Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions. (17157267)Hsiao G.... Sheu J.R.2007CASP3, NOS2
11Hippocampal cellular stress responses after global brain ischemia and reperfusion. (17715997)Roberts G.G.... DeGracia D.J.2007CA1, XBP1
12A transmissible cytotoxic activity isolated from a patient with brain ischemia causes microglial cell activation and dysfunction. (17380379)Beretti F.... Cermelli C.2007CCL3
13Differential changes in phosphorylation of tau at PHF-1 and 12E8 epitopes during brain ischemia and reperfusion in gerbils. (17191139)Gordon-Krajcer W.... Ksiezak-Reding H.2007MAPT
14Ca2+ signals and neuronal death in brain ischemia. (17261713)Bano D.... Nicotera P.2007SLC24A3
15Effects of maternal treatment with corticosteroids on tight junction protein expression in the cerebral cortex of the ovine fetus with and without exposure to in utero brain ischemia. (17583681)Malaeb S.N.... Stonestreet B.S.2007TJP1, CLDN5
16Characterization of the eIF2-associated protein p67 during brain ischemia and reperfusion. (17288737)Owen C.... Krause G.2006EIF2S1
17Vascular protection in brain ischemia. (16651811)RodrA-guez-YA!A+ez M.... Castillo J.2006HMGCR
18Cytochrome c binds to inositol (1,4,5) trisphosphate and ryanodine receptors in vivo after transient brain ischemia in gerbils. (16513219)Beresewicz M.... ZabA8ocka B.2006RYR2, CYCS
19Expression of amyloid beta protein and amyloid precursor protein after focal brain ischemia in human (16253167)Luan T.Z.... Chen Y.X.2005APP
20Poly(ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury. (15953818)Strosznajder R.P.... Zambrzycka A.2005PARP1
21Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: results of a phase II clinical trial. (15947262)Daffertshofer M.... Hennerici M.G.2005PLAT
22The superoxide dismutase1 (SOD1) G93A mutation does not promote neuronal injury after focal brain ischemia and optic nerve transection in mice. (15350647)Kilic E.... Bahr M.2004SOD1
23Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia. (15567345)Katsura K.... Bazan N.G.2004DYT10
24Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. (15161641)Nakase T.... Naus C.C.2004GJA1
25PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus. (15044063)Song B.... Zhang G.Y.2004CAMK2A, SYNGAP1
26Transglutaminase activity and transglutaminase mRNA transcripts in gerbil brain ischemia. (15172109)Ientile R.... Calapai G.2004TGM2, TGM3
27Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia. (12687390)Page A.B.... Krause G.S.2003EIF2S1, EIF2A
28Proliferation of neural and neuronal progenitors after global brain ischemia in young adult macaque monkeys. (12812760)Tonchev A.B.... Okano H.2003GFAP, DCX, MSI1
29N-methyl-D-aspartate receptor and L-type voltage-gated Ca(2+) channel antagonists suppress the release of cytochrome c and the expression of procaspase-3 in rat hippocampus after global brain ischemia. (12147322)Zhang C.... Zhang G.2002APAF1, CASP9, CYCS
30Why do Purkinje cells die so easily after global brain ischemia? Aldolase C, EAAT4, and the cerebellar contribution to posthypoxic myoclonus. (11968459)Welsh J.P.... Aicher S.A.2002ALDOA
31Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia. (12419528)Hou X.Y.... Liu Y.2002FYN, GRIN2A, DLG4
32Rapid loss of microvascular integrin expression during focal brain ischemia reflects neuron injury. (11435796)Tagaya M.... del Zoppo G.J.2001ITGA1
33Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. (11054482)White B.C.... Krause G.S.2000EIF2S1
34Changes and mechanisms of protein-tyrosine kinase and protein-tyrosine phosphatase activities after brain ischemia/reperfusion. (11501180)Pei L.... Zhu Z.M.2000SRC, PTK2B, ACP1
35Up-regulation of protein-disulfide isomerase in response to hypoxia/brain ischemia and its protective effect against apoptotic cell death. (10744727)Tanaka S.... Nomura Y.2000P4HB, PDIA2
36Potential role of calcineurin for brain ischemia and traumatic injury. (10321795)Morioka M.... Miyamoto E.1999DUSP19
37Oxidative stress in brain ischemia. (9989455)Love S.1999PARP1, NOS1
38Stress protein inductions after brain ischemia. (9876877)Abe K.... Itoyama Y.1998MT-CO1
39Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. (9861045)Yrjanheikki J.... Koistinaho J.1998NOS2, CARD16
40Amyloid beta peptide and precursor protein (APP) in mild and severe brain ischemia. (9329712)Jendroska K.... Patt S.1997APP
41An increase in cerebrospinal fluid ubiquitin in huma n global brain ischemia--a prognostic marker for anoxic-ischemic encephalopathy (9503964)Kurimura M.... Kato T.1997RPS27A
42The effects of 2-chloroadenosine and deoxycoformycin on the ATP level, Na-K ATPase activity in experimental brain ischemia of gerbil. (8875454)TA1rkAPzkan N.... Aykol S.1996ADA
43Biphasic enhancement of nitric oxide synthase activity and cGMP level following brain ischemia in gerbils. (8787213)Strosznajder J.... Chalimoniuk M.1996NOS2
44Increased F1/GAP-43 mRNA accumulation in gerbil hippocampus after brain ischemia. (7593346)Tagaya M.... Sugita M.1995GAP43
45Effect of cytochrome C and its derivatives on blood circulation and oxidative metabolism of the brain in ischemia (8834222)Pogorelyi V.E.... Gatsura V.V.1995CYCS
46Kininogen consumption in cerebral circulation of huma ns during brain ischemia and postischemic reperfusion. (7749387)Makevnina L.G.... Semenyutin V.B.1994KNG1
47Dopamine metabolism and free-radical related mitochon drial injury during transient brain ischemia in gerbils. (8255372)Ishii H.... Spatz M.1993SOD1
48Reduction in second-messenger ligand binding sites after brain ischemia--autoradiographic Bmax and Kd determinations using digital image analysis. (8319103)Tanaka K.... Nagata E.1993ADCY10, DYT10
49Preferential expression of HSC70 heat shock mRNA in gerbil heart after transient brain ischemia. (8263947)Abe K.... Isoyama S.1993HSPA8, HSPA4
50Phospholipid metabolism and second messenger system after brain ischemia. (1636489)Abe K.... Kogure K.1992HSPA4

Expression for genes affiliated with Brain Ischemia

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Brain Ischemia

Pathways for genes affiliated with Brain Ischemia

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10EMD Millipore, 41Thomson Reuters, 20KEGG, 36QIAGEN, 3Cell Signaling Technology
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Pathways related to brain ischemia according to GeneDecks:

(show top 50)    (show all 180)
idPathwayScoreTop Affiliating Genes
1Development Leptin signaling via JAK/STAT and MAPK cascades1010.8EGR1, MAPK3
2Development_Leptin signaling via JAK/STAT and MAPK cascades4110.6EGR1, CYCS
3Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR14110.5CYCS, MAPK3, NOS3
4Apoptosis and survival Role of CDK5 in neuronal death and survival1010.5APAF1, CASP9, CYCS
5Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)419.9HSPA8, NOS2, NOS3, NOS1, HSPA4, SOD1
6Immune response IFN gamma signaling pathway109.8CAMK2G, SRC, CAMK2A, PTK2B
7Development_Endothelin-1/EDNRA signaling419.8CAMK2G, MAPK10, CAMK2A, SRC, PTK2B, PRKCD
8Colorectal cancer209.8CASP9, FOS
9Signal transduction Erk Interactions- Inhibition of Erk109.7CAMK2G, CAMK2A, MAPK1, MAPK10, GRIN2A, MAPK3
10Apoptosis and survival_Role of CDK5 in neuronal death and survival419.6APAF1, PRKCD, CYCS, CASP9, CASP3, MAPK1
11Sertoli-Sertoli Cell Junction Dynamics369.6CLDN5, TJP1, NOS1, SRC, TUBB3, MAPK1
12TRKA Signaling369.6MAPK1, CASP3, PRKCD, MAPK10, MAPK3, CASP9
13Development Endothelin-1/EDNRA signaling109.4CAMK2G, PTK2B, SRC, MAPK10, MAPK3, MAPK1
14LT-BetaR Pathway369.4CASP3, MAPK3, CASP9, MAPK1, APAF1, CYCS
15TNF-Induced Apoptosis Implicating Sphingolipids369.4CYCS, CASP9, CASP3, MAPK1, MAPK3, MAPK10
16Neuroscience39.3GAP43, MSI1, GRIN2A, APP, MAPT, MAP2
17Alzheimers Disease Pathway369.3CAPN1, MAPT, MAPK1, SRC, PRKCD, APP
18GnRH signaling pathway209.3CAMK2G, CAMK2A, MAPK10, PTK2B, SRC, MAPK3
19VEGF Pathway369.3MAPK3, MAPK1, PTK2B, CASP9, SRC, NOS3
20Immune response_IFN gamma signaling pathway419.3CAMK2A, MAPK1, PRKCD, MAPK3, SRC, PTK2B
21Signal transduction_Erk Interactions- Inhibition of Erk419.3MAPK10, PRKCD, GRIN2A, CAMK2G, CAMK2A, MAPK3
22Translation Translation regulation by Alpha-1 adrenergic receptors109.2EIF4G1, SRC, PTK2B, CAMK2G, MAPK1, PRKCD
23Melatonin Signaling369.2CAMK2A, CAMK2G, MAPK10, MAPK3, FOS, KCNK10
24Endothelin-1 Signaling Pathway369.2CCL3, MAPK10, MAPK1, MAPK3, CASP3, PRKCD
25Calcium signaling pathway209.2SLC8A2, SLC8A3, NOS3, NOS2, CAMK2A, NOS1
26Amyotrophic lateral sclerosis (ALS)209.2APAF1, GRIN2A, CYCS, CASP3, CASP9, NOS1
27Translation_Translation regulation by Alpha-1 adrenergic receptors419.1MAPK1, PTK2B, PRKCD, EIF4G1, SRC, CAMK2G
28Alzheimers disease209.1APP, NOS1, MT-CO1, EIF2AK3, GRIN2A, CYCS
29Development_ACM2 and ACM4 activation of ERK419.0PRKCD, EGR1, PTK2B, FOS, CAMK2A, FYN
30Development ACM2 and ACM4 activation of ERK109.0FYN, EGR1, PTK2B, CAMK2G, CAMK2A, MAPK1
31UVA-Induced MAPK Signaling368.9FOS, MAPK1, CASP3, CYCS
32Tuberculosis208.8CYCS, CAMK2A, CASP3, MAPK1, APAF1, MAPK10
33Ceramide Pathway368.8CASP3, CYCS, PRKCD, MAPK10, MAPK3, FOS
34UVC-Induced MAPK Signaling368.8FOS, PRKCD, SRC, MAPK1, MAPK10, MAPK3
35TNF Signaling368.8CYCS, MAPK1, CASP9, FOS, APAF1, MAPK3
36Development_G-Proteins mediated regulation MARK-ERK signaling418.7CAMK2A, MAPK1, SYNGAP1, SRC, PTK2B, MAPK3
37Development G-Proteins mediated regulation MARK-ERK signaling108.7CAMK2G, CAMK2A, MAPK1, MAPK3, FOS, SRC
38Development Endothelin-1/EDNRA transactivation of EGFR108.7SRC, PTK2B, CAMK2G, CAMK2A, MAPK1, PRKCD
39Development_Endothelin-1/EDNRA transactivation of EGFR418.6FOS, PRKCD, SRC, PTK2B, MAPK3, CAMK2G
40Development Angiotensin activation of ERK108.6PRKCD, SRC, MAPK1, MAPK3, CAMK2A, CAMK2G
41Development_Angiotensin activation of ERK418.6MAPK1, CAMK2A, CAMK2G, PTK2B, SRC, PRKCD
42Development Angiotensin signaling via PYK2108.6FOS, MAPK3, PTK2B, PRKCD, SRC, CAMK2G
43Development_Angiotensin signaling via PYK2418.6FOS, PRKCD, MAPK3, MAPK10, MAPK1, CAMK2A
44Development VEGF signaling via VEGFR2 - generic cascades108.6FOS, MAPK3, MAPK1, SRC, NOS3, PRKCD
45CCKBR-Gastrin Stimulated Signaling368.6FOS, MAPK3, MAPK10, PTK2B, MAPK1, SRC
46Development_Activation of ERK by Alpha-1 adrenergic receptors418.6FOS, MAPK3, MAPK1, CAMK2G, PTK2B, TGM2
47Development Activation of ERK by Alpha-1 adrenergic receptors108.6MAPK1, FOS, CAMK2G, PRKCD, TGM2, SRC
48Development_VEGF signaling via VEGFR2 - generic cascades418.3PRKCD, NOS3, NOS2, MAPK3, SRC, MAPK1
49Neuropathic Pain-Signaling in Dorsal Horn Neurons368.1MAPK3, CAMK2A, PRKCD, NOS1, SRC, KCNK4
50Molecular Mechanisms of Cancer368.0CASP3, MAPK1, CAMK2A, CAMK2G, CYCS, SYNGAP1

Compounds for genes affiliated with Brain Ischemia

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32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
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Compounds related to brain ischemia according to GeneDecks:

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idCompoundScoreTop Affiliating Genes
1carbachol32 9 9 12.5MAPK10, CTSB, KNG1, ADORA1
2manumycin32 10.2DYT10, SRC, GDNF
3glucose32 9.8CKB, MT-CO1, XBP1, HYOU1, ALDOA, GJA1
4egcg32 9.5APP, MAPK3, MAPK10, CASP9, PTK2B, CYCS
5c2ceramide32 9.5PARP1, HSPA4, CASP3, DYT10, DUSP19, CYCS
6pge232 9.3VIP, MAPK10, CCL3, HSPA8, GJA1, DUSP19
7phosphatidylserine32 9 9 11.1PARP1, SCG5, APAF1, MAPT, CAPN1, CASP9
8aspartate32 8.7SELP, VIP, BDNF, CKB, APP, CCL3
9potassium32 9 18 9 11.5VIP, BDNF, KCNB1, KCNK4, KCNK10, CKB
105-hydroxytryptamine32 8.4VIP, FYN, CDKN3, APP, CAMK2G, DLG4
11alanine32 8.4VIP, SCG5, P4HB, FYN, MAPK3, MAPK10
12nitric oxide32 9 18 9 11.4SELP, P4HB, APAF1, MAP2, MAPK3, CCL3
13kainate32 8.3BDNF, CDKN3, FOS, GRIN2A, MAPT, MAP2
14okadaic acid32 42 9.3CDKN3, FOS, MAPT, MAP2, MAPK3, MAPK10
15norepinephrine32 9 18 9 11.2SELP, VIP, BDNF, APP, MAP2, MAPK3
16cyclic amp32 18 9.2BDNF, CKB, XBP1, FYN, FOS, MAP2
17rapamycin32 42 9.2VEGFA, BDNF, MAPK10, CAMK2G, CASP9, HMGCR
18histamine32 18 9.1SELP, VIP, BDNF, SCG5, AQP4, MAPK10
19cyclosporin a32 42 9.1SELP, VIP, FYN, CDKN3, APP, MAPT
20gaba32 42 9.0VIP, BDNF, CKB, CDKN3, GRIN2A, APP
21h2o232 8.0VIP, BDNF, XDH, FYN, CDKN3, APAF1
22n acetylcysteine32 7.9SELP, BDNF, FOS, MAPT, MAPK10, HMGCR
23sb 20358032 42 8.7VEGFA, PARP1, FOS, MAPK10, HSPA4, CASP3
24forskolin32 42 9 9 10.6VIP, BDNF, CKB, FOS, MAPK3, MAPK10
25herbimycin a32 42 8.6FYN, CDKN3, FOS, MAPK3, MAPK10, MAPK1
26doxorubicin32 34 9 9 10.6VEGFA, PARP1, BDNF, APAF1, MAPT, HSPA4
27acetylcholine32 9 18 9 10.5VIP, BDNF, CDKN3, APP, MAPT, MAPK10
28resveratrol32 9 18 9 10.5VEGFA, PARP1, XDH, APAF1, MAPK3, MAPK10
29ly29400232 7.4VEGFA, CDKN3, FOS, MAPK1, CCL3, CASP3
30cysteine32 7.4SELP, PARP1, SCG5, P4HB, XDH, FYN
31paclitaxel32 34 9 9 10.3VEGFA, PARP1, BDNF, APAF1, APP, MAPT
32pdtc32 7.3PARP1, XDH, FOS, MAPK10, MAPK1, CCL3
33oxygen32 18 8.2PARP1, BDNF, CKB, MT-CO1, P4HB, FYN
344-hydroxynonenal32 18 8.1PARP1, XDH, FOS, APP, MAPT, MAPK1
35phosphoinositide32 7.1BDNF, XBP1, FYN, CDKN3, FOS, MAP2
36thapsigargin32 42 8.1VIP, BDNF, XBP1, CDKN3, APP, MAPK3
37diphenyleneiodonium32 6.8VEGFA, XDH, CDKN3, MAPK3, MAPK10, MAPK1
38indomethacin32 9 9 8.7VIP, BDNF, CDKN3, MAPK3, CCL3, HSPA4
39pd 98,05932 6.7PARP1, BDNF, FOS, MAPK3, MAPK10, MAPK1
40curcumin32 6.7VEGFA, PARP1, FOS, APP, MAPK3, MAPK10
41cisplatin32 34 9 9 9.6VEGFA, PARP1, BDNF, XDH, CDKN3, APAF1
42arsenite32 18 7.4VEGFA, PARP1, CDKN3, FOS, MAPK3, MAPK10
43phosphatidylinositol32 6.3BDNF, FYN, CDKN3, FOS, APAF1, MAP2
44atp32 6.0PARP1, BDNF, SCG5, CKB, MT-CO1, P4HB
45genistein32 9 18 9 8.9SELP, VEGFA, PARP1, FYN, CDKN3, FOS
46retinoic acid32 42 18 7.7SELP, PARP1, BDNF, P4HB, FYN, CDKN3
47dexamethasone32 42 34 9 9 9.6SELP, VIP, VEGFA, PARP1, SCG5, ITGA1
48calcium32 9 18 9 8.5VIP, LPHN1, BDNF, KCNB1, SCG5, P4HB
49glutamate32 5.4VIP, SCG5, P4HB, FYN, CDKN3, FOS
50tyrosine32 4.9SELP, VIP, VEGFA, BDNF, SCG5, P4HB

GO Terms for genes affiliated with Brain Ischemia

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Sources:
12Gene Ontology
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Cellular components related to brain ischemia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle membraneGO:03066610.0CAMK2A, DLG4, NOS3, RPS27A, CAMK2G
2caveolaGO:0059019.5NOS3, CTSB, SRC, MAPK3, MAPK1
3neuronal cell bodyGO:0430259.2MAP2, HSPA8, SLC8A3, SLC8A2, ADCY10, ADA
4cytoplasmGO:0057376.4RBFOX3, TJP1, TUBB3, AIF1, CA1, CASP3
5cytosolGO:0058295.7NOS3, SRC, NOS1, NOS2, RPS27A, EIF4G1
6plasma membraneGO:0058865.1ITGA1, MAPT, MAPK10, HSPA8, CAPN1, CASP3

Biological processes related to brain ischemia according to GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1arginine catabolic processGO:00652710.5NOS3, NOS2, NOS1
2negative regulation of potassium ion transportGO:04326710.4PTK2B, NOS1, NOS3
3cellular response to interferon-gammaGO:07134610.3NOS2, AIF1, AQP4, CCL3
4regulation of synaptic plasticityGO:04816710.3SYNGAP1, PLAT, BDNF, ADORA1
5protein autophosphorylationGO:04677710.2EIF2S1, PTK2B, TRPM7, EIF2AK3, CAMK2G, CAMK2A
6activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:00863510.1CYCS, APAF1, CASP3, CASP9
7visual learningGO:00854210.1APP, GRIN2A, HMGCR, SYNGAP1
8positive regulation of neuron apoptotic processGO:04352510.1MAP3K11, ITGA1, CASP9, CASP3, CCL3
9response to woundingGO:00961110.0GAP43, ADORA3, GFAP, CTSB, CASP3, GRIN2A
10negative regulation of gene expressionGO:01062910.0FYN, CCL3, NOS2, AIF1, XDH, GJA1
11cytokine-mediated signaling pathwayGO:01922110.0MAPK3, CAMK2A, CAMK2G, HLA-A, RPS27A, EGR1
12protein phosphorylationGO:0064689.9CAMK2G, FYN, APP, PTK2B, EIF2A, EIF2AK3
13calcium ion transportGO:0068169.9RYR2, CAMK2G, CAMK2A, CCL3, FYN, SLC24A1
14nervous system developmentGO:0073999.7BDNF, AQP4, APAF1, GDNF, DLG4, ADORA1
15synaptic transmissionGO:0072689.7ACP1, KCNB1, DLG4, CAMK2G, CAMK2A, HSPA8
16regulation of sequence-specific DNA binding transcription factor activityGO:0510909.6MAPK1, MAPK10, MAPK3, FOS
17activation of MAPK activityGO:0001879.5ITGA1, RPS27A, SOD1, MAP3K11, MAPK1, MAPK10
18calcium ion transport into cytosolGO:0604029.5RYR2, SLC8A2, SLC8A3
19response to hypoxiaGO:0016669.5NOS3, ADA, ADORA1, VEGFA, HYOU1, CAMK2G
20platelet degranulationGO:0025769.4SOD1, KNG1, APP, VEGFA, SELP, ALDOA
21response to ethanolGO:0454719.4FYN, GRIN2A, CTSB, NOS3, SOD1
22stress-activated MAPK cascadeGO:0514039.3FOS, MAPK10, MAPK1, RPS27A, MAPK3
23MyD88-independent toll-like receptor signaling pathwayGO:0027569.3MAPK3, FOS, MAPK10, RPS27A, MAPK1
24fibroblast growth factor receptor signaling pathwayGO:0085439.3PRKCD, RPS27A, MAPK3, MAPK1, CASP9, SRC
25TRIF-dependent toll-like receptor signaling pathwayGO:0356669.3MAPK3, MAPK10, MAPK1, RPS27A, FOS
26toll-like receptor 1 signaling pathwayGO:0341309.2MAPK10, RPS27A, MAPK3, FOS, MAPK1
27toll-like receptor 3 signaling pathwayGO:0341389.2FOS, MAPK10, MAPK1, MAPK3, RPS27A
28toll-like receptor 2 signaling pathwayGO:0341349.1RPS27A, MAPK1, MAPK10, MAPK3, FOS
29toll-like receptor signaling pathwayGO:0022249.1MAPK10, MAPK1, MAPK3, RPS27A, FOS
30axon guidanceGO:0074119.1SRC, DCX, GDNF, DLG4, TUBB3, MAPK1
31MyD88-dependent toll-like receptor signaling pathwayGO:0027559.0RPS27A, FOS, MAPK1, MAPK10, MAPK3
32nerve growth factor receptor signaling pathwayGO:0480119.0CASP3, PRKCD, MAPK3, MAPK1, CASP9, ADCYAP1
33epidermal growth factor receptor signaling pathwayGO:0071739.0SRC, PRKCD, CASP9, MAPK1, RPS27A, MAPK3
34apoptotic processGO:0069158.7APAF1, GJA1, PRKCD, PDIA2, RPS27A, CYCS
35platelet activationGO:0301688.3PRKCD, SOD1, KNG1, ALDOA, SELP, FYN
36blood coagulationGO:0075967.8MAPK3, KNG1, SRC, PLAT, NOS1, VEGFA

Molecular functions related to brain ischemia according to GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:00451710.2NOS2, NOS1, NOS3
2tetrahydrobiopterin bindingGO:03461710.2NOS1, NOS2, NOS3
3arginine bindingGO:03461810.1NOS3, NOS1, NOS2
4calmodulin bindingGO:0055169.3MAP2, CAMK2A, CAMK2G, TJP1, NOS1, NOS2
5receptor bindingGO:0051028.7HLA-A, APP, HSPA8, GJA1, GDNF, SRC
6ATP bindingGO:0055248.6PTK2B, SRC, EIF2AK3, PRKCD, ADCY10, TRPM7
7protein bindingGO:0055152.6GAP43, NOS1, PLSCR3, PLAT, CTSB, SRC

Sources for Brain Ischemia

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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