MCID: BRN080
MIFTS: 41

Brain Ischemia malady

Neuronal diseases category

Summaries for Brain Ischemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Brain ischemia (aka ischemic stroke, cerebral ischemia, cerebrovascular ischemia) is a condition in... more...

MalaCards: Brain Ischemia is related to ischemia and alzheimer's disease. An important gene associated with Brain Ischemia is NES (nestin), and among its related pathways are Cytoskeleton remodeling Neurofilaments and Development A3 receptor signaling. The drugs papaverine and papaverine hydrochloride and the compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Brain Ischemia

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10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain ischemia 10 44 30 60


Related Diseases for Brain Ischemia

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17GeneCards, 18GeneDecks
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Diseases related to Brain Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia31.9ADORA3, HSPA4, CKB, TUBB3, ADORA1, NOS1
2alzheimer's disease30.3CAPN1, CAMK2G, TUBB3, CKB, DYT10, CTSB
3transient cerebral ischemia30.2ADORA1, MAP2, CAMK2G, HSPA4
4hyperglycemia30.2DYT10
5hypertension30.1PLAT
6herpes simplex29.9EGR1, GDNF, EIF2S1
7schizophrenia29.9HSPA4, MAP2, GDNF, NOS1, ADCY10
8atherosclerosis29.9HSPA4, DYT10, EGR1, PLAT, NOS1, ADCY10
9dementia29.9HSPA4, MAPK3, MAP2, NOS1
10hypoglycemia29.9ADORA1
11neuronitis10.8
12cerebritis10.6
13cerebral artery occlusion10.4
14brain disease10.3
15brain edema10.2
16brain compression10.1
17angioedema10.1
18pancreatic cancer10.0GDNF, NES
19pancreatitis10.0CTSB
20pick's disease10.0TUBB3
21pituitary adenoma10.0NES, GDNF, ADCY10
22polyneuropathy10.0GDNF
23colorectal cancer10.0CKB, CTSB, EGR1, ADCY10
24cervical cancer10.0MAP2, MAPK3, DYT10
25oligodendroglioma10.0MAP2
26myocardial infarction10.0NOS1, HYOU1, PLAT, CKB
27arthritis10.0ADORA3, CTSB
28fibrosarcoma10.0CTSB, EGR1, NES
29ovarian cancer10.0MAPK3, CTSB, TUBB3, CKB
30diabetes mellitus10.0HSPA4, DYT10, PLAT
31teratocarcinoma10.0GDNF, EGR1
32mood disorder10.0MAP2, GDNF, NOS1, ADORA1, ADCY10
33cystic fibrosis10.0CAMK2G, DYT10, ADORA1, ADCY10
34toxic encephalopathy10.0HSPA4, MAP2, GDNF
35malignant glioma10.0DYT10, CTSB, EGR1, NES
36prion disease10.0CAMK2G, MAP2, GDNF, NOS1, ADORA1, ADCY10
37pneumonia10.0NOS1, CTSB, HSPA4
38vascular disease10.0HSPA4, EGR1, MAPK3, MAP2, NOS1, ADORA1
39adenocarcinoma10.0CKB, CTSB, EGR1, NES, MAPK3, EIF2AK3
40sarcoma10.0ADCY10, NES, HSPA4
41stroke, ischemic10.0PLAT, HSPA4
42astrocytoma10.0ADCY10, ADORA3, GDNF, MAP2, NES, EGR1
43prostate cancer10.0TUBB3, CAMK2G, DYT10, CTSB, EGR1, NES
44epilepsy syndrome10.0HSPA4, CAMK2G, EGR1, NES, MAPK3, MAP2
45osteosarcoma10.0HSPA4, DYT10, CTSB, EGR1, MAPK3, EIF2S1
46lung small cell carcinoma10.0CKB, DYT10, MAPK3, MAP2, GDNF, ADCY10
47epiphyseal dysplasia multiple with early-onset diabetes mellitus10.0EIF2S1, EIF2AK3
48adenoma10.0CTSB, NES, MAPK3, GDNF, EIF2S1, NOS1
49non-small cell lung carcinoma10.0CKB, TUBB3, CTSB, EGR1, MAPK3, EIF2AK3
50cadasil10.0MAPK3, NES, CAPN1, CAMK2G, CKB, HSPA4

Graphical network of the top 20 diseases related to Brain Ischemia:



Diseases related to brain ischemia

Clinical Features for Brain Ischemia

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Drugs & Therapeutics for Brain Ischemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Brain Ischemia

Drug clinical trials:

Search ClinicalTrials for Brain Ischemia

Search NIH Clinical Center for Brain Ischemia

Search CenterWatch for Brain Ischemia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Brain Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Ischemia:
Mesenchymal stem cell-derived neuronal progenitor cells for the treatment of ischemic brain damage
Embryonic/Adult Cultured Cells Related to Brain Ischemia:
Neural progenitor cells, PMID: 21300404

Genetic Tests for Brain Ischemia

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Anatomical Context for Brain Ischemia

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32MalaCards
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MalaCards organs/tissues related to Brain Ischemia:

32
Brain

Animal Models for Brain Ischemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Brain Ischemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.6PLAT, ADORA1, NOS1, TUBB3, GDNF, MAP2
2MP:000538610.5CKB, HSPA4, CTSB, MAPK3, EGR1, NES
3MP:000538410.5NOS1, HYOU1, PLAT, EIF2AK3, GDNF, EGR1
4MP:001076810.5EIF2S1, MAP2, HSPA4, NOS1, HYOU1, PLAT
5MP:000537610.4MAPK3, EGR1, CTSB, CAPN1, EIF2S1, EIF2AK3
6MP:000537810.4GDNF, CTSB, EGR1, NES, NOS1, MAP2
7MP:000537910.4HSPA4, EGR1, GDNF, EIF2S1, EIF2AK3
8MP:000538710.4MAPK3, ADORA3, NOS1, PLAT, CAMK2G, CAPN1
9MP:000538510.3PLAT, ADORA1, NOS1, GDNF, MAPK3, EGR1
10MP:000538810.1ADORA1, NOS1, ADORA3, MAPK3, EGR1, TUBB3

Publications for Brain Ischemia

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Genetic Variations for Brain Ischemia

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Expression for genes affiliated with Brain Ischemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Ischemia

Search GEO for disease gene expression data for Brain Ischemia.

Pathways for genes affiliated with Brain Ischemia

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Sources:
12EMD Millipore, 53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Brain Ischemia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.5MAP2, NES, TUBB3
2
Development A3 receptor signaling
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10.5MAPK3, ADORA3, ADORA1
3
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10.5EIF2AK3, EIF2S1
4
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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10.4MAPK3, EGR1, MAP2
5
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10.4EIF2S1, HYOU1, EIF2AK3
6
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10.4ADCY10, ADORA1, NOS1, MAPK3, CAMK2G
7
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10.4MAPK3, EGR1, CAPN1, ADORA1
810.4NOS1, GDNF, MAPK3, EGR1
910.4EIF2AK3, EIF2S1, HYOU1, CAPN1
10
Translation Insulin regulation of translation
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10.4MAPK3, EGR1, EIF2S1, PLAT, EIF2AK3
11
Hide members
10.4CAPN1, NOS1, EIF2AK3, EIF2S1, MAPK3
1210.4NOS1, MAP2, EGR1, CAPN1, CAMK2G, TUBB3

Compounds for genes affiliated with Brain Ischemia

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Brain Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 200)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.9ADCY10, CAPN1, CKB
2estrogen4410.9ADORA1, MAP2
3glutamate4410.9ADORA3, HYOU1, PLAT, GDNF, CAPN1, CAMK2G
4kainate44 2811.8HSPA4, CAMK2G, CTSB, NES, MAP2, GDNF
5serine4410.8TUBB3, CAMK2G, CTSB, MAP2, GDNF, EIF2S1
6dopamine44 28 11 2413.8CAMK2G, EGR1, NES, MAPK3, MAP2, GDNF
7nmda44 2811.8HSPA4, CAMK2G, DYT10, EGR1, MAPK3, MAP2
8gaba4410.8CKB, TUBB3, CAMK2G, NES, MAP2, GDNF
9oxygen44 2411.8HSPA4, CAMK2G, CTSB, NES, GDNF, EIF2S1
10glucose4410.8CKB, CAMK2G, CTSB, EGR1, MAP2, GDNF
11carbachol44 28 1112.8CAMK2G, DYT10, CTSB, EGR1, MAPK3, NOS1
12thapsigargin44 5911.8HSPA4, CAMK2G, CAPN1, DYT10, CTSB, EGR1
13isoproterenol44 1111.8HSPA4, CAMK2G, CTSB, MAPK3, PLAT, NOS1
14nitric oxide44 11 2412.8MAPK3, MAP2, GDNF, EIF2S1, EIF2AK3, NOS1
15adenylate4410.8HSPA4, CAMK2G, DYT10, EGR1, MAP2, GDNF
16cyclic amp44 2411.8CKB, CAMK2G, DYT10, EGR1, MAPK3, MAP2
17phosphoinositide4410.8CAMK2G, DYT10, EGR1, MAPK3, MAP2, GDNF
18aspartate4410.8HSPA4, CKB, CTSB, MAPK3, GDNF, EIF2S1
19tamoxifen44 49 28 1113.8CKB, DYT10, MAPK3, EIF2AK3
20atp44 2811.8EGR1, CAPN1, CAMK2G, CKB, HSPA4, MAPK3
21cocaine44 1111.8HSPA4, CAMK2G, EGR1, MAP2, GDNF, NOS1
22ly2940024410.8HSPA4, CAMK2G, DYT10, CTSB, EGR1, MAPK3
23atropine44 28 1112.8CTSB, EGR1, MAPK3, NOS1, ADORA1, ADCY10
24gf 109203x44 5911.8HSPA4, CAMK2G, DYT10, CTSB, EGR1, MAPK3
25superoxide44 2411.7CAMK2G, CAPN1, EGR1, MAP2, EIF2S1, NOS1
26vegf4410.7EGR1, CTSB, DYT10, CAMK2G, HSPA4, NES
27genistein44 28 59 2 11 2415.7HSPA4, DYT10, EGR1, MAPK3, GDNF, NOS1
28retinoic acid44 2411.7CTSB, DYT10, CAMK2G, TUBB3, HSPA4, EGR1
29calcium44 49 11 2413.7CKB, TUBB3, ADCY10, ADORA3, ADORA1, NOS1
30norepinephrine44 11 2412.7CAMK2G, EGR1, MAPK3, MAP2, GDNF, NOS1
31acetylcholine44 49 28 11 2414.7HSPA4, CAMK2G, EGR1, NES, GDNF, NOS1
32h2o24410.7HSPA4, CAMK2G, DYT10, CTSB, EGR1, MAPK3
33ionomycin4410.7CAMK2G, CAPN1, DYT10, EGR1, MAPK3, MAP2
34forskolin44 49 1112.7CKB, EGR1, MAPK3, GDNF, ADORA3
35bapta4410.7CAMK2G, DYT10, EGR1, MAPK3, ADORA1
36alanine4410.7HSPA4, CKB, CAMK2G, CTSB, MAPK3, GDNF
37tyrosine4410.7TUBB3, CAMK2G, CAPN1, DYT10, CTSB, EGR1
38okadaic acid44 5911.7CAMK2G, DYT10, EGR1, MAPK3, MAP2, GDNF
39actinomycin d4410.7HSPA4, CAMK2G, DYT10, CTSB, EGR1, GDNF
40dexamethasone44 49 28 1113.6HSPA4, CAMK2G, EGR1, MAPK3, GDNF, NOS1
41bromodeoxyuridine4410.6HSPA4, TUBB3, NES, MAPK3, MAP2, GDNF
42indomethacin44 59 28 1113.6HSPA4, CTSB, EGR1, MAPK3, PLAT, NOS1
43heparin44 28 11 2413.6CAMK2G, CTSB, MAP2, GDNF, EIF2S1
44creatinine4410.6HSPA4, CKB, CAPN1, CTSB, GDNF, HYOU1
45histamine44 28 2412.5CAMK2G, DYT10, PLAT, NOS1, ADORA1, ADORA3
46pd 98,0594410.5HSPA4, CAMK2G, DYT10, EGR1, MAPK3, GDNF
47phenylephrine44 28 11 2413.4CAMK2G, DYT10, MAPK3, NOS1, ADORA1
48gnrh4410.4PLAT, MAPK3, NES, EGR1, DYT10, CAMK2G
49dmso4410.3HSPA4, TUBB3, CTSB, NES, MAP2, NOS1
50potassium44 11 2412.1HSPA4, CKB, CAMK2G, MAP2, GDNF, ADORA1

GO Terms for genes affiliated with Brain Ischemia

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16Gene Ontology
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Biological processes related to Brain Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of histone acetylationGO:03506610.5NOS1, MAPK3
2activation of signaling protein activity involved in unfolded protein responseGO:00698710.4HYOU1, EIF2AK3, EIF2S1
3endoplasmic reticulum unfolded protein responseGO:03096810.3EIF2S1, EIF2AK3, HYOU1
4interleukin-1-mediated signaling pathwayGO:07049810.1MAPK3, EGR1

Molecular functions related to Brain Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00552410.4ADCY10, HYOU1, EIF2AK3, MAPK3, CAMK2G, CKB
2G-protein coupled adenosine receptor activityGO:00160910.2ADORA3, ADORA1

Products for genes affiliated with Brain Ischemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brain Ischemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet