MCID: BRN080
MIFTS: 45

Brain Ischemia

Categories: Neuronal diseases

Aliases & Classifications for Brain Ischemia

MalaCards integrated aliases for Brain Ischemia:

Name: Brain Ischemia 37 51 69

Classifications:



External Ids:

UMLS 69 C0007786

Summaries for Brain Ischemia

MalaCards based summary : Brain Ischemia is related to ischemia and neuronitis. An important gene associated with Brain Ischemia is KCNB1 (Potassium Voltage-Gated Channel Subfamily B Member 1), and among its related pathways/superpathways are Melatonin metabolism and effects and Photodynamic therapy-induced HIF-1 survival signaling. The drugs Aspirin and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include Brain and Brain.

Wikipedia : 72 Brain ischemia (a.k.a. cerebral ischemia, cerebrovascular ischemia) is a condition in which there is... more...

Related Diseases for Brain Ischemia

Diseases related to Brain Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 ischemia 29.8 ADORA1 EDN1 GFAP KCNB1 MAP2 NOS2
2 neuronitis 10.5
3 central nervous system teratoma 10.4 GFAP NES
4 anaplastic ganglioglioma 10.4 GFAP NES
5 central nervous system germ cell tumor 10.4 GFAP NES
6 central nervous system primitive neuroectodermal neoplasm 10.4 GFAP NES
7 ependymoblastoma 10.4 GFAP NES
8 astroblastoma 10.4 GFAP NES
9 subependymoma 10.3 GFAP NES
10 medulloepithelioma 10.3 GFAP NES
11 tanycytic ependymoma 10.3 GFAP NES
12 papillary ependymoma 10.3 GFAP NES
13 gliomatosis cerebri 10.3 GFAP NES
14 subependymal giant cell astrocytoma 10.3 GFAP NES
15 retinitis pigmentosa 42 10.3 GFAP NES
16 cerebritis 10.3
17 brain glioma 10.3 GFAP NES
18 chiari malformation 10.3 GFAP MAP2
19 hemimegalencephaly 10.2 GFAP MAP2
20 periventricular leukomalacia 10.2 NES NOS2
21 ependymoma 10.2 GFAP NES
22 leukomalacia 10.2 NES NOS2
23 infratentorial cancer 10.2 GFAP NES
24 cerebellar liponeurocytoma 10.2 GFAP MAP2
25 mucopolysaccharidosis, type iiia 10.2 MAP2 NES
26 optic nerve neoplasm 10.2 MAP2 NES
27 neuronal migration disorders 10.1 MAP2 NES
28 clear cell ependymoma 10.1 GFAP MAP2
29 neurilemmoma 10.1 GFAP NES
30 aging 10.0
31 hypoxia 10.0
32 sleeping sickness 10.0 HSPA8 NOS2
33 hepatopulmonary syndrome 10.0 EDN1 NOS2
34 dysembryoplastic neuroepithelial tumor 10.0 GFAP MAP2 NES
35 central neurocytoma 10.0 GFAP MAP2 NES
36 optic nerve glioma 10.0 GFAP MAP2 NES
37 ganglioglioma 10.0 GFAP MAP2 NES
38 lutheran suppressor, x-linked 10.0 ADORA1 EDN1
39 hydrops, lactic acidosis, and sideroblastic anemia 9.9
40 brain injury 9.9
41 alzheimer disease 9.9
42 blood group, i system 9.9
43 cardiac arrest 9.9
44 cerebral artery occlusion 9.9
45 scrapie 9.9 GFAP MAP2
46 spinal cord injury 9.8 GFAP NOS2
47 multiple mitochondrial dysfunctions syndrome 5 9.8
48 hyperglycemia 9.8
49 endotheliitis 9.8
50 medulloblastoma 9.8 GFAP MAP2 NES

Graphical network of the top 20 diseases related to Brain Ischemia:



Diseases related to Brain Ischemia

Symptoms & Phenotypes for Brain Ischemia

Drugs & Therapeutics for Brain Ischemia

Drugs for Brain Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 446)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-78-2 2244
2
Cilostazol Approved, Investigational Phase 4,Phase 3 73963-72-1 2754
3
Probucol Approved, Investigational Phase 4 23288-49-5 4912
4
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
5
Levodopa Approved Phase 4 59-92-7 6047
6
Ephedrine Approved Phase 4,Phase 2 299-42-3 9294
7
Oxymetazoline Approved, Investigational Phase 4,Phase 2 1491-59-4 4636
8
Phenylephrine Approved Phase 4,Phase 2 59-42-7 6041
9
Pseudoephedrine Approved Phase 4,Phase 2 90-82-4 7028
10
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 120202-66-6, 113665-84-2 60606
11
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55142-85-3 5472
12
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
13
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
14
Angiotensin II Approved, Investigational Phase 4,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
15
Atenolol Approved Phase 4 29122-68-7 2249
16
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
17
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
18 Nadroparin Approved, Investigational Phase 4 9041-08-1
19
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 7440-66-6 32051 23994
20
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 7487-88-9 24083
21
Dalteparin Approved Phase 4,Phase 2 9005-49-6
22
Warfarin Approved Phase 4,Phase 2,Phase 3 81-81-2 54678486 6691
23
Apixaban Approved Phase 4,Phase 3 503612-47-3 10182969
24 Edoxaban Approved Phase 4,Phase 2,Phase 3 480449-70-5
25
Rivaroxaban Approved Phase 4,Phase 2 366789-02-8
26 Piracetam Approved, Investigational Phase 4,Phase 2 7491-74-9
27
Dipyridamole Approved Phase 4 58-32-2 3108
28
Triflusal Approved, Investigational Phase 4 322-79-2
29
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3 51-43-4 5816
30 Racepinephrine Approved Phase 4,Phase 2,Phase 3 329-65-7
31
Amlodipine Approved Phase 4,Phase 2 88150-42-9 2162
32
Losartan Approved Phase 4 114798-26-4 3961
33
Antipyrine Approved, Investigational Phase 4,Phase 3,Phase 2 60-80-0 2206
34
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
35
Pravastatin Approved Phase 4,Phase 3 81093-37-0 54687
36
Simvastatin Approved Phase 4,Phase 3,Phase 2 79902-63-9 54454
37
Allopurinol Approved Phase 4,Phase 3 315-30-0 2094
38
Fluvastatin Approved Phase 4 93957-54-1 1548972
39
Tranexamic Acid Approved Phase 4 1197-18-8 5526
40
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
41
Abciximab Approved Phase 4,Phase 3 143653-53-6
42
Choline Approved, Nutraceutical Phase 4,Phase 3 62-49-7 305
43 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
44 Tocopherol Approved, Investigational, Nutraceutical Phase 4,Phase 2,Phase 1
45
Vitamin C Approved, Nutraceutical Phase 4,Phase 2 50-81-7 54670067 5785
46
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 59-02-9 14985
47 Ozagrel Investigational Phase 4 82571-53-7
48 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 842)

# Name Status NCT ID Phase Drugs
1 PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study Unknown status NCT02483169 Phase 4 cilostazol;Probucol;Aspirin;placebo of cilostazol;Placebo of aspirin
2 PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage Unknown status NCT01013532 Phase 4 Cilostazol;Probucol;Aspirin;placebo of cilostazol;placebo of aspirin
3 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
4 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
5 Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery Unknown status NCT01794273 Phase 4 ephedrine and phenylephrine
6 The Dynamic Effect of Non-cytochrome P450 Isoenzyme 3A4(CYP3A4)-Metabolized and Cytochrome P450 Isoenzyme 3A4(CYP3A4)-Metabolized Statins on Clopidogrel Resistance in Patients With Cerebral Infarction Unknown status NCT02411903 Phase 4 atorvastatin and clopidogrel;rosuvastatin and clopidogrel
7 Nimodipine for Treating Acute Massive Cerebral Infarction Unknown status NCT02248233 Phase 4 Nimodipine;Saline + citicoline
8 The Effect of Erigeron Injection on Acute Cerebral Infarction Serum VEGF, MMP-9 and EPC Levels Unknown status NCT01926834 Phase 4 Erigeron Injection;placebo
9 Comprehensive Reparative Therapy in Ischemic Stroke COMplex Repair in Ischemic Stroke-Arm Unknown status NCT02581371 Phase 4 Cerebrolysin infusion
10 Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol Unknown status NCT02403349 Phase 4 Fimasartan;Valsartan;Atenolol
11 Safety and Efficacy of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke Unknown status NCT01862978 Phase 4 Heparin;Nadroparin;Placebo
12 Efficacy Study of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke Unknown status NCT01758536 Phase 4 Huatuo Zaizao Pills
13 Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy Unknown status NCT01097967 Phase 4
14 Valsartan Efficacy on Modest Blood Pressure Reduction in Acute Ischemic Stroke Unknown status NCT00874601 Phase 4 Diovan® (valsartan)
15 Comparison of Two Strategies for Glycemic Control in Acute Ischemic Stroke Unknown status NCT00747279 Phase 4 Intensive insulin therapy
16 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4 Butylphthalide Soft Capsules;Aspirin
17 Single High Dose Vitamin C, E in Severe Birth Asphyxia Completed NCT01743742 Phase 4 Vitamin E, Vitamin C
18 ESPRIT: European/Australasian Stroke Prevention in Reversible Ischaemia Trial Completed NCT00161070 Phase 4 anticoagulation;aspirin and dipyridamole;aspirin alone
19 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4 magnesium
20 Post-marketing Clinical Study of Alteplase for Acute Ischemic Stroke (Japan Alteplase Clinical Trial Ⅱ:J-ACT Ⅱ) Completed NCT00412867 Phase 4 Alteplase
21 The Effect of Cilostazol Compared to Aspirin on Endothelial Function in Acute Cerebral Ischemia Patients Completed NCT03116269 Phase 4 Cilostazol 100mg;Aspirin
22 The Effect of Ventilation on Cerebral Oxygenation in the Sitting Position Completed NCT01546636 Phase 4
23 Clopidogrel Response and CYP2C19 Genotype in Ischemic Stroke Patients Completed NCT03385538 Phase 4 Clopidogrel
24 AdminiStration of Statin On Acute Ischemic stRoke patienT Trial Completed NCT02549846 Phase 4 Statin
25 Atorvastatin in Acute Stroke Treatment Completed NCT02225834 Phase 4 Atorvastatin
26 A Safety Study of Ginkgolides Meglumine Injection in the Treatment of Ischemic Stroke. Completed NCT01958957 Phase 4 Ginkgolides Meglumine Injection
27 Tongxinluo Capsule in Ischemic Stroke Patients(TISS) Completed NCT01919671 Phase 4 Tongxinluo capsule;placebo capsule
28 Comparison of Triflusal and Clopidogrel in Secondary Prevention of Stroke Based on the Genotyping Completed NCT01174693 Phase 4 Triflusal;Clopidogrel
29 Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke Completed NCT01762163 Phase 4 Qizhitongluo Capsule;Naoxintong Capsule;Aspirin Enteric-coated Tablets;placebo
30 Effect of Cilostazol in the Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler Completed NCT00741286 Phase 4 Aspirin;cilostazol
31 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
32 Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke Completed NCT01109836 Phase 4
33 Thrombectomy REvascularization of Large Vessel Occlusions in Acute Ischemic Stroke (TREVO) Completed NCT01088672 Phase 4
34 Overcome Biochemical Aspirin Resistance Through Cilostazol Combination Completed NCT00446641 Phase 4 Cilostazol;placebo
35 Establishment and Evaluation to the Effects of a Clinical Pathway for Acute Ischemic Stroke Completed NCT00966316 Phase 4 aspirin,chinese herbs;
36 Preventing Recurrent Vascular Events in Patients With Stroke or Transient Ischemic Attack Completed NCT00931788 Phase 4 Antihypertensive agents and lipid lowering therapy
37 Study of Continuous Cardiac Monitoring to Assess Atrial Fibrillation After Cryptogenic Stroke Completed NCT00924638 Phase 4
38 Safety and Efficacy of Clopidogrel for Cerebral Infarction Treatment Completed NCT00386191 Phase 4 clopidogrel (SR25990C)
39 The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke Completed NCT00868283 Phase 4 Cerebrolysin;0.9% Saline Solution
40 AISTCM-Outcome Measurement of Acute Ischemic Stroke With Traditional Chinese Medicine Completed NCT00351806 Phase 4 Erigeron breviscapus injection;hua tuo zai zao wan (a herbal medicine pill);Compound stroke herbal medicine (8 herbal)
41 Study of Cilostazol and Probucol Alone and in Combination on Atherosclerosis Related Biomarker---atherosclerosis Cerebral Infarction Patient as Study Subject Completed NCT00823875 Phase 4 Cilostazol group;Probucol group;Cilostazol + Probucol group;control group
42 Platelet Hyperreactivity to Aspirin and Stroke Completed NCT00766896 Phase 4 Aspirin (platelet sensitive versus platelet hyperreactivity)
43 The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED) Completed NCT00754429 Phase 4 losartan;amlodipine
44 Cilostazol in Acute Ischemic Stroke Treatment (CAIST) Completed NCT00272454 Phase 4 Cilostazol;Aspirin
45 Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) Completed NCT00234065 Phase 4 Cilostazol;Aspirin
46 Efficacy and Safety of Cilostazol for the Indication of CSPS Completed NCT00216749 Phase 4
47 Edaravone-Sodium Ozagrel Comparative Post-Marketing Study on Acute Ischemic Stroke Completed NCT00200356 Phase 4 Edaravone;Sodium Ozagrel
48 Merci Registry - Real World Use of the Merci Retrieval System in Acute Ischemic Stroke Completed NCT00478478 Phase 4
49 Quality Improvement in Stroke Prevention (QUISP) Completed NCT00328640 Phase 4 Optimal treatment
50 The Study on Profile and Genetic Factors of Aspirin Resistance (ProGEAR Study) Completed NCT00250380 Phase 4

Search NIH Clinical Center for Brain Ischemia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Ischemia:
Mesenchymal stem cell-derived neuronal progenitor cells for the treatment of ischemic brain damage
Embryonic/Adult Cultured Cells Related to Brain Ischemia:
Neural progenitor cells PMIDs: 21300404

Genetic Tests for Brain Ischemia

Anatomical Context for Brain Ischemia

MalaCards organs/tissues related to Brain Ischemia:

38
Brain, Bone, Bone Marrow, Endothelial, Heart, Testes, Cortex
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Brain Ischemia:
# Tissue Anatomical CompartmentCell Relevance
1 Brain Forebrain White Matter Fibrous Astrocyte Cells Potential therapeutic candidate
2 Brain Neocortex Protoplasmic Astrocyte Cells Potential therapeutic candidate

Publications for Brain Ischemia

Articles related to Brain Ischemia:

(show top 50) (show all 658)
# Title Authors Year
1
Neuroprotective effects of valproic acid on brain ischemia are related to its HDAC and GSK3 inhibitions. ( 29452136 )
2018
2
A de novo Ser111Thr variant in aquaporin-4 in a patient with intellectual disability, transient signs of brain ischemia, transient cardiac hypertrophy, and progressive gait disturbance. ( 29437797 )
2018
3
Activation of JAK/STAT3 restores NK-cell function and improves immune defense after brain ischemia. ( 29401578 )
2018
4
Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia. ( 29315561 )
2018
5
SUMOylation in brain ischemia: Patterns, targets, and translational implications. ( 29148315 )
2018
6
The protective effect of alpha-lipoic acid against brain ischemia and reperfusion injury via mTOR signaling pathway in rats. ( 29432779 )
2018
7
Reactive Oxygen Species Play a Biphasic Role in Brain Ischemia. ( 29420085 )
2018
8
Glutamate dehydrogenase as a neuroprotective target against brain ischemia and reperfusion. ( 27845178 )
2017
9
The effects of Y-27632 on pial microvessels during global brain ischemia and reperfusion in rabbits. ( 28270098 )
2017
10
LOTUS overexpression accelerates neuronal plasticity after focal brain ischemia in mice. ( 28880879 )
2017
11
Profiling and identification of new proteins involved in brain ischemia using MALDI-imaging-mass-spectrometry. ( 27888142 )
2017
12
Quinolinyl Nitrone RP19 Induces Neuroprotection after Transient Brain Ischemia. ( 28731692 )
2017
13
Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage. ( 29248829 )
2017
14
Author Correction: Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. ( 29138397 )
2017
15
Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia. ( 29110329 )
2017
16
G5G2.5 core-shell tecto-dendrimer specifically targets reactive glia in brain ischemia. ( 29280499 )
2017
17
Longitudinal Assessments of Normal and Perilesional Tissues in Focal Brain Ischemia and Partial Optic Nerve Injury with Manganese-enhanced MRI. ( 28230106 )
2017
18
The Protein Modification and Degradation Pathways after Brain Ischemia. ( 28967038 )
2017
19
Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial. ( 29058596 )
2017
20
Shifting Perceptions of Risk and Reward: Use of Anticoagulation in Patients With Acute Brain Ischemia and Atrial Fibrillation: Nine-Year Data From a National Acute Stroke Registry (National Acute Stroke Israeli Survey [NASIS]). ( 28258255 )
2017
21
Brain Ischemia Suppresses Immunity in the Periphery and Brain via Different Neurogenic Innervations. ( 28314594 )
2017
22
Aromatase and neuroinflammation in rat focal brain ischemia. ( 28964927 )
2017
23
Semi-synthetic sapogenin exerts neuroprotective effects by skewing the brain ischemia reperfusion transcriptome towards inflammatory resolution. ( 28390980 )
2017
24
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. ( 28642575 )
2017
25
Early Reperfusion After Brain Ischemia Has Beneficial Effects Beyond Rescuing Neurons. ( 28626056 )
2017
26
Reverse electron transfer results in a loss of flavin from mitochondrial complex I: Potential mechanism for brain ischemia reperfusion injury. ( 28914132 )
2017
27
Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia. ( 28843543 )
2017
28
Nontraditional Lipid Variables Predict Recurrent Brain Ischemia in Embolic Stroke of Undetermined Source. ( 28412318 )
2017
29
Condition-specific transcriptional regulation of neuronal ion channel genes in brain ischemia. ( 29348796 )
2017
30
The T-type calcium channel enhancer SAK3 inhibits neuronal death following transient brain ischemia via nicotinic acetylcholine receptor stimulation. ( 28457878 )
2017
31
Radiographic and symptomatic brain ischemia in CEA and CAS: A systematic review and meta-analysis. ( 29021357 )
2017
32
Brain ischemia: CT and MRI techniques in acute ischemic stroke. ( 29054448 )
2017
33
Combined l-citrulline and glutathione administration prevents neuronal cell death following transient brain ischemia. ( 28315310 )
2017
34
Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation. ( 28360842 )
2017
35
Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia. ( 28053883 )
2017
36
Serum Levels of S100b and NSE Proteins in Patients with Non-Transfusion-Dependent Thalassemia as Biomarkers of Brain Ischemia and Cerebral Vasculopathy. ( 29244749 )
2017
37
Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. ( 28431607 )
2017
38
G6PD plays a neuroprotective role in brain ischemia through promoting pentose phosphate pathway. ( 28823591 )
2017
39
A new threshold of apparent diffusion coefficient values in white matter after successful tissue plasminogen activator treatment for acute brain ischemia. ( 28187865 )
2017
40
Microglia-mediated BAFF-BAFFR ligation promotes neuronal survival in brain ischemia injury. ( 28918255 )
2017
41
Partial loss of VE-cadherin improves long-term outcome and cerebral blood flow after transient brain ischemia in mice. ( 27538712 )
2016
42
The Role of I_ Opioid Receptor in Brain Ischemia. ( 27495821 )
2016
43
Concurrent Glycogen and Lactate Imaging with FTIR Spectroscopy To Spatially Localize Metabolic Parameters of the Glial Response Following Brain Ischemia. ( 27690391 )
2016
44
SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion. ( 27882949 )
2016
45
PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia. ( 27423516 )
2016
46
Neuroprotective effect of resveratrol against brain ischemia reperfusion injury in rats entails reduction of DJ-1 protein expression and activation of PI3K/Akt/GSK3b survival pathway. ( 27109835 )
2016
47
Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia. ( 27889412 )
2016
48
Butylphthalide Suppresses Neuronal Cells Apoptosis and Inhibits JNK-Caspase3 Signaling Pathway After Brain Ischemia /Reperfusion in Rats. ( 27015680 )
2016
49
Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia. ( 27656217 )
2016
50
Brain ischemia with Alzheimer phenotype dysregulates Alzheimer's disease-related proteins. ( 26940197 )
2016

Variations for Brain Ischemia

Expression for Brain Ischemia

Search GEO for disease gene expression data for Brain Ischemia.

Pathways for Brain Ischemia

Pathways related to Brain Ischemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 EDN1 MAP2
2 10.72 EDN1 NOS2
3 10.7 GFAP MAP2 NES
4 10.49 ADCY10 EDN1

GO Terms for Brain Ischemia

Cellular components related to Brain Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 9.26 GFAP NES
2 dendrite GO:0030425 9.26 ADCY10 ADORA1 KCNB1 MAP2
3 basal part of cell GO:0045178 9.16 ADCY10 EDN1
4 cell body GO:0044297 8.8 ADORA1 GFAP MAP2

Biological processes related to Brain Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.43 ADORA1 EDN1 NOS2
2 negative regulation of blood pressure GO:0045776 9.37 ADORA1 NOS2
3 regulation of sensory perception of pain GO:0051930 9.32 ADORA1 EDN1
4 positive regulation of cardiac muscle hypertrophy GO:0010613 9.16 EDN1 PARP1
5 regulation of protein complex assembly GO:0043254 8.96 GFAP HSPA8
6 negative regulation of hormone secretion GO:0046888 8.62 ADORA1 EDN1

Molecular functions related to Brain Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heat shock protein binding GO:0031072 8.96 ADORA1 HSPA8
2 structural molecule activity GO:0005198 8.8 GFAP MAP2 NES

Sources for Brain Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....