MCID: BRN080
MIFTS: 52

Brain Ischemia malady

Neuronal category

Summaries for Brain Ischemia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Brain ischemia, also known as cerebral ischemia, is a condition in which there is insufficient blood... more...

MalaCards: Brain Ischemia is related to alzheimer's disease and transient cerebral ischemia. An important gene associated with Brain Ischemia is NES (nestin), and among its related pathways are Cytoskeleton remodeling Neurofilaments and Development A3 receptor signaling. The drugs papaverine and papaverine hydrochloride and the compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Brain Ischemia

Sources:
10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

brain ischemia 10 45 31 61


Related Diseases for Brain Ischemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Brain Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1alzheimer's disease30.4CAPN1, CAMK2G, TUBB3, CKB, DYT10, CTSB
2transient cerebral ischemia30.3ADORA1, MAP2, CAMK2G, HSPA4
3atherosclerosis29.9HSPA4, DYT10, EGR1, PLAT, NOS1, ADCY10
4hypoglycemia29.9ADORA1
5brain injury10.8
6hypoxia10.4
7cerebral artery occlusion10.3
8brain disease10.3
9brain edema10.3
10traumatic brain injury10.2
11brain compression10.1
12angioedema10.1
13memory impairment10.1
14pancreatic cancer10.0GDNF, NES
15pancreatitis10.0CTSB
16pick's disease10.0TUBB3
17pituitary adenoma10.0NES, GDNF, ADCY10
18polyneuropathy10.0GDNF
19colorectal cancer10.0CKB, CTSB, EGR1, ADCY10
20cervical cancer10.0MAP2, MAPK3, DYT10
21herpes simplex10.0EGR1, GDNF, EIF2S1
22oligodendroglioma10.0MAP2
23myocardial infarction10.0NOS1, HYOU1, PLAT, CKB
24arthritis10.0ADORA3, CTSB
25fibrosarcoma10.0CTSB, EGR1, NES
26ovarian cancer10.0MAPK3, CTSB, TUBB3, CKB
27diabetes mellitus10.0HSPA4, DYT10, PLAT
28teratocarcinoma10.0GDNF, EGR1
29mood disorder10.0MAP2, GDNF, NOS1, ADORA1, ADCY10
30cystic fibrosis10.0CAMK2G, DYT10, ADORA1, ADCY10
31toxic encephalopathy10.0HSPA4, MAP2, GDNF
32malignant glioma10.0DYT10, CTSB, EGR1, NES
33prion disease10.0CAMK2G, MAP2, GDNF, NOS1, ADORA1, ADCY10
34schizophrenia10.0HSPA4, MAP2, GDNF, NOS1, ADCY10
35pneumonia10.0NOS1, CTSB, HSPA4
36vascular disease10.0HSPA4, EGR1, MAPK3, MAP2, NOS1, ADORA1
37adenocarcinoma10.0CKB, CTSB, EGR1, NES, MAPK3, EIF2AK3
38sarcoma10.0ADCY10, NES, HSPA4
39stroke, ischemic10.0PLAT, HSPA4
40astrocytoma10.0ADCY10, ADORA3, GDNF, MAP2, NES, EGR1
41prostate cancer10.0TUBB3, CAMK2G, DYT10, CTSB, EGR1, NES
42epilepsy syndrome10.0HSPA4, CAMK2G, EGR1, NES, MAPK3, MAP2
43osteosarcoma10.0HSPA4, DYT10, CTSB, EGR1, MAPK3, EIF2S1
44lung small cell carcinoma10.0CKB, DYT10, MAPK3, MAP2, GDNF, ADCY10
45epiphyseal dysplasia multiple with early-onset diabetes mellitus10.0EIF2S1, EIF2AK3
46adenoma10.0CTSB, NES, MAPK3, GDNF, EIF2S1, NOS1
47non-small cell lung carcinoma10.0CKB, TUBB3, CTSB, EGR1, MAPK3, EIF2AK3
48cadasil10.0MAPK3, NES, CAPN1, CAMK2G, CKB, HSPA4
49glioblastoma multiforme10.0CKB, TUBB3, DYT10, CTSB, EGR1, NES
50meningitis10.0GDNF

Graphical network of the top 20 diseases related to Brain Ischemia:



Diseases related to brain ischemia

Clinical Features for Brain Ischemia

Drugs & Therapeutics for Brain Ischemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Brain Ischemia

Drug clinical trials:

Search ClinicalTrials for Brain Ischemia

Search NIH Clinical Center for Brain Ischemia

Search CenterWatch for Brain Ischemia

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Brain Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Ischemia:
Mesenchymal stem cell-derived neuronal progenitor cells for the treatment of ischemic brain damage
Embryonic/Adult Cultured Cells Related to Brain Ischemia:
Neural progenitor cells, PMID: 21300404

Genetic Tests for Brain Ischemia

Anatomical Context for Brain Ischemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Brain Ischemia:

33
Bone marrow, Whole blood, Brain, Cortex, Cerebellum, Spinal cord, Heart, Kidney, Liver, Skin, Monocytes, T cells, B cells, Endothelial, Fetal brain, Prefrontal cortex, Cardiac myocytes, Fetal liver, Pituitary

Animal Models for Brain Ischemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Brain Ischemia

Sources:
51PubMed
See all sources

Articles related to Brain Ischemia:

(show top 50)    (show all 796)
idTitleAuthorsYear
1
Autophagy in the brain of neonates following hypoxia-ischemia shows sex- and region-specific effects. (24184979)
2014
2
Cerebral microvascular damage occurs early after hypoxia-ischemia via nNOS activation in the neonatal brain. (24398931)
2014
3
HuR Function and Translational State Analysis Following Global Brain Ischemia and Reperfusion. (24323414)
2013
4
Brain targeted solid lipid nanoparticles for brain ischemia: preparation and in vitro characterization. (23477526)
2013
5
Neuroprotective action of acute estrogens: animal models of brain ischemia and clinical implications. (23385013)
2013
6
The relation between persistent coma and brain ischemia after severe brain injury. (23627555)
2013
7
Improvement in Memory and Brain Long-term Potentiation Deficits Due to Permanent Hypoperfusion/Ischemia by Grape Seed Extract in Rats. (24171080)
2013
8
Treadmill exercise ameliorates impairment of spatial learning ability through enhancing dopamine expression in hypoxic ischemia brain injury in neonatal rats. (24278893)
2013
9
Microglial P2Y12 deficiency/inhibition protects against brain ischemia. (23940669)
2013
10
Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction. (22158864)
2012
11
Characterization of neuroprotective effects of biphalin, an opioid receptor agonist, in a model of focal brain ischemia. (21856861)
2011
12
Heat shock proteins as biomarkers for the rapid detection of brain and spinal cord ischemia: a review and comparison to other methods of detection in thoracic aneurysm repair. (20803353)
2011
13
Relationship between inflammatory reaction and ischemic injury of caudate-putamen in rats: inflammatory reaction and brain ischemia. (20809266)
2011
14
Brain natriuretic peptide (BNP) as a biomarker of myocardial ischemia-reperfusion injury in cardiac transplantation. (20655247)
2010
15
Involvement of mitochondria on neuroprotective effect of sphingosine-1-phosphate in cell death in an in vitro model of brain ischemia. (20045720)
2010
16
Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia. (20029450)
2010
17
Ischemia induces endoplasmic reticulum stress and cell apoptosis in human brain. (20347937)
2010
18
Hypoxic tissues are associated with microvessel density following brain ischemia-reperfusion. (20957504)
2010
19
Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation. (19406109)
2009
20
Geldanamycin protects rat brain through overexpression of HSP70 and reducing brain edema after cerebral focal ischemia. (18534054)
2008
21
Cushing's triad in pneumococcal meningitis due to brainstem ischemia: early detection by diffusion-weighted MRI. (18358408)
2008
22
Neuroprotection of GST, an extract of traditional Chinese herb, against ischemic brain injury induced by transient brain ischemia and reperfusion in rat hippocampus. (18953737)
2008
23
Rasagiline is neuroprotective in an experimental model of brain ischemia in the rat. (17177075)
2007
24
Cytokine gene expression in kidney allograft biopsies after donor brain death and ischemia-reperfusion injury using in situ reverse-transcription polymerase chain reaction analysis. (17998866)
2007
25
Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction. (17272778)
2007
26
Protective effects of Guizhi-Fuling-Capsules on rat brain ischemia/reperfusion injury. (17895588)
2007
27
PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. (17556100)
2007
28
Erythropoietin prevents blood brain barrier damage induced by focal cerebral ischemia in mice. (17562165)
2007
29
Less neurogenesis and inflammation in the immature than in the juvenile brain after cerebral hypoxia-ischemia. (16926844)
2007
30
Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. (16166574)
2005
31
Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm. (14969736)
2004
32
Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2. (15380477)
2004
33
Time-dependent changes in CRH concentrations and release in discrete brain regions following global ischemia: effects of MK-801 pretreatment. (15234251)
2004
34
Hypoperfusion and Its Augmentation in Patients with Brain Ischemia. (12777197)
2003
35
Possible mechanisms underlying the protective effects of SY-21, an extract of a traditional Chinese herb, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampus. (14556939)
2003
36
Blood-brain barrier drug targeting enables neuroprotection in brain ischemia following delayed intravenous administration of neurotrophins. (12575830)
2002
37
Bilobalide, a component of the Ginkgo biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity. (12396077)
2002
38
Blockade of A(2A) adenosine receptors leads to c-fos inhibition in a rat model of brain ischemia. (11846624)
2002
39
Immediate anticoagulation in acute focal brain ischemia revisited: gathering the evidence. (11157200)
2001
40
Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system. (11387502)
2001
41
Age-related neuronal vulnerability to brain ischemia: A potential target of gene therapy. (23604873)
2001
42
Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures. (11311331)
2001
43
Maximum length sequence brainstem auditory evoked responses in term neonates who have perinatal hypoxia-ischemia. (11044485)
2000
44
Stress protein inductions after brain ischemia. (9876877)
1998
45
Effects of brain temperature on calmodulin and microtubule-associated protein 2 immunoreactivity in the gerbil hippocampus following transient forebrain ischemia. (9069442)
1997
46
Biphasic enhancement of nitric oxide synthase activity and cGMP level following brain ischemia in gerbils. (8787213)
1996
47
GLUT1 and GLUT3 gene expression in gerbil brain following brief ischemia: an in situ hybridization study. (7808230)
1994
48
Ischemia-induced changes in alpha-tubulin and beta-actin mRNA in the gerbil brain and effects of bifemelane hydrochloride. (8435749)
1993
49
Brain polyamines are controlled by N-methyl-D-aspartate receptors during ischemia and recirculation. (2146783)
1990
50
Tourniquet subclavian steal: brainstem ischemia and cortical blindness--clinical significance and testing. (7304302)
1981

Genetic Variations for Brain Ischemia

Expression for genes affiliated with Brain Ischemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Brain Ischemia

Search GEO for disease gene expression data for Brain Ischemia.

Pathways for genes affiliated with Brain Ischemia

Sources:
12EMD Millipore, 54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 4Cell Signaling Technology
See all sources

Pathways related to Brain Ischemia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5TUBB3, NES, MAP2
2
Development A3 receptor signaling
Hide members
10.5ADORA3, ADORA1, MAPK3
3
Hide members
10.5EIF2AK3, EIF2S1
4
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
10.4MAP2, MAPK3, EGR1
5
Hide members
10.4EIF2S1, EIF2AK3, HYOU1
6
Hide members
10.4ADCY10, ADORA1, NOS1, MAPK3, CAMK2G
7
Hide members
10.4CAPN1, EGR1, MAPK3, ADORA1
810.4EGR1, MAPK3, GDNF, NOS1
910.4CAPN1, EIF2S1, EIF2AK3, HYOU1
10
Translation Insulin regulation of translation
Hide members
10.4EGR1, MAPK3, EIF2S1, EIF2AK3, PLAT
11
Hide members
10.4NOS1, EIF2AK3, EIF2S1, MAPK3, CAPN1
1210.4NOS1, MAP2, EGR1, CAPN1, CAMK2G, TUBB3

Compounds for genes affiliated with Brain Ischemia

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Brain Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 200)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.9CKB, CAPN1, ADCY10
2estrogen4510.9ADORA1, MAP2
3glutamate4510.9CAMK2G, ADORA3, CAPN1, HYOU1, PLAT, GDNF
4kainate45 2911.8GDNF, ADORA1, HSPA4, CAMK2G, PLAT, CTSB
5serine4510.8TUBB3, CAMK2G, CTSB, GDNF, MAP2, EIF2S1
6dopamine45 29 11 2413.8GDNF, CAMK2G, ADORA1, EGR1, NES, MAPK3
7nmda45 2911.8MAPK3, MAP2, NOS1, ADORA1, EGR1, DYT10
8gaba4510.8CAMK2G, GDNF, NES, MAP2, CKB, NOS1
9oxygen45 2411.8NES, HSPA4, CAMK2G, CTSB, GDNF, EIF2S1
10glucose4510.8CKB, HYOU1, PLAT, EIF2S1, MAP2, EGR1
11carbachol45 29 1112.8ADCY10, CAMK2G, MAPK3, EGR1, ADORA1, NOS1
12thapsigargin45 6011.8CAMK2G, ADCY10, HSPA4, EIF2AK3, CAPN1, DYT10
13isoproterenol45 1111.8NOS1, PLAT, ADCY10, MAPK3, CTSB, CAMK2G
14nitric oxide45 11 2412.8EIF2S1, GDNF, MAP2, MAPK3, NES, EGR1
15adenylate4510.8ADORA3, DYT10, ADCY10, GDNF, PLAT, MAP2
16cyclic amp45 2411.8ADCY10, ADORA3, ADORA1, GDNF, MAP2, MAPK3
17phosphoinositide4510.8MAP2, MAPK3, EGR1, ADORA1, DYT10, GDNF
18aspartate4510.8HSPA4, CKB, CTSB, EIF2S1, ADORA1, NOS1
19tamoxifen45 50 29 1113.8CKB, MAPK3, DYT10, EIF2AK3
20atp45 2911.8EIF2AK3, HYOU1, ADORA1, ADORA3, EIF2S1, GDNF
21cocaine45 1111.8GDNF, HSPA4, CAMK2G, EGR1, MAP2, ADORA1
22ly2940024510.8CAMK2G, DYT10, CTSB, EGR1, MAPK3, GDNF
23atropine45 29 1112.8NOS1, ADORA1, ADCY10, CTSB, MAPK3, EGR1
24gf 109203x45 6011.8DYT10, CTSB, EGR1, MAPK3, ADCY10, CAMK2G
25superoxide45 2411.7CAMK2G, CAPN1, EGR1, MAP2, EIF2S1, ADORA3
26vegf4510.7HSPA4, DYT10, CTSB, EGR1, NES, MAPK3
27genistein45 29 60 2 11 2415.7MAPK3, DYT10, GDNF, ADCY10, EGR1, HSPA4
28retinoic acid45 2411.7TUBB3, HSPA4, GDNF, PLAT, NOS1, MAP2
29calcium45 50 11 2413.7CKB, TUBB3, CAMK2G, EGR1, MAPK3, MAP2
30norepinephrine45 11 2412.7ADORA1, CAMK2G, EGR1, ADCY10, MAPK3, NOS1
31acetylcholine45 50 29 11 2414.7HSPA4, CAMK2G, NOS1, ADORA1, ADCY10, GDNF
32h2o24510.7MAPK3, MAP2, GDNF, NOS1, CAMK2G, EGR1
33ionomycin4510.7MAP2, EIF2S1, MAPK3, EGR1, DYT10, CAPN1
34forskolin45 50 1112.7MAPK3, CKB, EGR1, GDNF, ADORA3
35bapta4510.7ADORA1, DYT10, EGR1, MAPK3, CAMK2G
36alanine4510.7HSPA4, CKB, CAMK2G, CTSB, MAPK3, GDNF
37tyrosine4510.7DYT10, NES, HYOU1, CAPN1, CAMK2G, TUBB3
38okadaic acid45 6011.7MAPK3, MAP2, DYT10, GDNF, CAMK2G, EIF2S1
39actinomycin d4510.7PLAT, GDNF, CAMK2G, EIF2S1, DYT10, CTSB
40dexamethasone45 50 29 1113.6GDNF, ADCY10, MAPK3, CAMK2G, EGR1, NOS1
41bromodeoxyuridine4510.6MAPK3, HSPA4, GDNF, MAP2, TUBB3, NES
42indomethacin45 60 29 1113.6HSPA4, CTSB, EGR1, NOS1, MAPK3, PLAT
43heparin45 29 11 2413.6CTSB, CAMK2G, EIF2S1, MAP2, GDNF
44creatinine4510.6NOS1, HYOU1, GDNF, CTSB, CAPN1, CKB
45histamine45 29 2412.5ADORA3, ADCY10, CAMK2G, DYT10, PLAT, NOS1
46pd 98,0594510.5EIF2AK3, HSPA4, CAMK2G, MAPK3, GDNF, EGR1
47phenylephrine45 29 11 2413.4DYT10, CAMK2G, MAPK3, NOS1, ADORA1
48gnrh4510.4CAMK2G, MAPK3, NES, EGR1, DYT10, PLAT
49dmso4510.3MAP2, CTSB, NES, TUBB3, HSPA4, NOS1
50potassium45 11 2412.1CKB, HSPA4, MAP2, GDNF, ADORA1, ADORA3

GO Terms for genes affiliated with Brain Ischemia

Sources:
16Gene Ontology
See all sources

Biological processes related to Brain Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of histone acetylationGO:03506610.5NOS1, MAPK3
2activation of signaling protein activity involved in unfolded protein responseGO:00698710.4HYOU1, EIF2AK3, EIF2S1
3endoplasmic reticulum unfolded protein responseGO:03096810.3EIF2S1, EIF2AK3, HYOU1
4interleukin-1-mediated signaling pathwayGO:07049810.1MAPK3, EGR1

Molecular functions related to Brain Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00552410.4ADCY10, HYOU1, EIF2AK3, MAPK3, CAMK2G, CKB
2G-protein coupled adenosine receptor activityGO:00160910.2ADORA3, ADORA1

Products for genes affiliated with Brain Ischemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brain Ischemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet