MCID: BRN080
MIFTS: 50

Brain Ischemia malady

Neuronal diseases category

Summaries for Brain Ischemia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Brain ischemia (aka ischemic stroke, cerebral ischemia, cerebrovascular ischemia) is a condition in... more...

MalaCards: Brain Ischemia is related to ischemia and alzheimer's disease. An important gene associated with Brain Ischemia is NES (nestin), and among its related pathways are Nucleotide-like (purinergic) receptors and Arginine and proline metabolism. The drugs papaverine and papaverine hydrochloride and the compounds cp608,039 and peneca have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and monocytes, and related mouse phenotypes are no phenotypic analysis and renal/urinary system.

Aliases & Classifications for Brain Ischemia

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Sources:
11DISEASES, 46Novoseek, 32LifeMap Discoveryā„¢, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain ischemia 11 46 32 63


Related Diseases for Brain Ischemia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Brain Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia31.6ADORA1, ADORA3, NES, GDNF, MAP2, CAMK2G
2alzheimer's disease30.2GDNF, ADORA1, MAP2, CAMK2G, CKB, NOS1
3schizophrenia29.8GDNF, ADCY10, MAP2, NOS1
4neuronitis10.8
5cerebritis10.6
6hypoxia10.4
7brain injury10.3
8cerebral artery occlusion10.3
9hyperglycemia10.2
10endotheliitis10.2
11angioedema10.1
12hypertension10.1
13hirschsprung's disease10.1GDNF
14ganglioglioma10.1MAP2
15pyloric stenosis10.1NOS1
16stroke, ischemic10.0NES, GDNF
17ependymoma10.0MAP2, NES
18glaucoma10.0ADORA1, ADORA3, GDNF
19congenital heart disease10.0ADCY10, CKB
20multiple system atrophy10.0MAP2, GDNF
21tuberous sclerosis10.0MAP2, NES
22temporal lobe epilepsy10.0GDNF, ADORA1, CAMK2G
23pituitary adenoma10.0GDNF, NES, ADCY10
24transient cerebral ischemia10.0CAMK2G, MAP2, ADORA1
25brain cancer10.0MAP2, NES, GDNF
26cystic fibrosis10.0ADORA1, ADCY10, CAMK2G
27toxic encephalopathy10.0GDNF, MAP2
28duchenne muscular dystrophy10.0NOS1, GDNF
29vascular dementia10.0
30hyperhomocysteinemia10.0
31hypoglycemia10.0
32brain edema10.0
33artery disease10.0
34atherosclerosis10.0
35carotid artery disease10.0
36dementia10.0
37ehlers-danlos syndrome10.0
38hepatitis10.0
39herpes simplex10.0
40protein-energy malnutrition10.0
41mitochondrial cardiomyopathy10.0
42aneurysm10.0
43anoxia10.0
44myoclonus10.0
45traumatic brain injury10.0
46memory impairment10.0
47pheochromocytoma10.0MAP2, ADCY10, GDNF
48factor v leiden thrombophilia10.0NES, ADCY10, NOS1
49vascular disease10.0ADORA1, MAP2, NOS1
50bipolar disorder9.9NOS1, MAP2, GDNF

Graphical network of the top 20 diseases related to Brain Ischemia:



Diseases related to brain ischemia

Symptoms for Brain Ischemia

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Drugs & Therapeutics for Brain Ischemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Brain Ischemia

Drug clinical trials:

Search ClinicalTrials for Brain Ischemia

Search NIH Clinical Center for Brain Ischemia

Search CenterWatch for Brain Ischemia

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Brain Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Ischemia:
Mesenchymal stem cell-derived neuronal progenitor cells for the treatment of ischemic brain damage
Embryonic/Adult Cultured Cells Related to Brain Ischemia:
Neural progenitor cells, PMID: 21300404

Genetic Tests for Brain Ischemia

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Anatomical Context for Brain Ischemia

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Sources:
34MalaCards
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MalaCards organs/tissues related to Brain Ischemia:

34
Brain, Cortex, Monocytes, Endothelial, Pituitary, Liver, Heart, Bone marrow, Bone, Prefrontal cortex

Animal Models for Brain Ischemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Brain Ischemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4NOS1, EIF2AK3, CAMK2G, ADORA3
2MP:00053678.2GDNF, ADORA3, ADORA1, NOS1
3MP:00053857.9GDNF, ADORA3, ADORA1, ADCY10, NOS1
4MP:00053897.6GDNF, ADCY10, MAP2, CAMK2G, NOS1
5MP:00053787.6GDNF, NES, MAP2, CKB, EIF2AK3, NOS1
6MP:00053767.5ADORA3, ADORA1, ADCY10, CAMK2G, EIF2AK3, NOS1
7MP:00036317.3GDNF, NES, ADORA1, MAP2, CKB, EIF2AK3
8MP:00053867.0NOS1, GDNF, NES, ADORA3, ADORA1, MAP2

Publications for Brain Ischemia

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Sources:
53PubMed
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Articles related to Brain Ischemia:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Onset of Orolingual Angioedema After Treatment of Acute Brain Ischemia with Alteplase Depends on the Site of Brain Ischemia: A Meta-analysis. (24350070)
2013
2
Effects of vinpocetine and ozagrel on behavioral recovery of rats after global brain ischemia. (24291485)
2013
3
Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neurons. (23355003)
2013
4
Protein misfolding, aggregation, and autophagy after brain ischemia. (24323413)
2013
5
DCX-expressing neurons decrease in the retrosplenial cortex after global brain ischemia. (22879023)
2013
6
Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction. (22158864)
2012
7
Eag1, Eag2, and SK3 potassium channel expression in the rat hippocampus after global transient brain ischemia. (22006722)
2012
8
Texture analysis of poly-adenylated mRNA staining following global brain ischemia and reperfusion. (21477879)
2012
9
Phenolic alkaloids from Menispermum dauricum rhizome protect against brain ischemia injury via regulation of GLT-1, EAAC1 and ROS generation. (22395403)
2012
10
E-selectin deficiency attenuates brain ischemia in mice. (22978829)
2012
11
Brain ischemia, neurogenesis, and neurotrophic receptor expression in primates. (21701994)
2011
12
'Functional histology' in brain ischemia studies. (21448216)
2011
13
Zinc: new clues to diverse roles in brain ischemia. (21621864)
2011
14
The protective effect of avocado soybean unsaponifilables on brain ischemia/reperfusion injury in rat prefrontal cortex. (20874457)
2011
15
Brain ischemia and hypometabolism treated by ozone therapy. (22105041)
2011
16
The effects of voluntary, involuntary, and forced exercises on brain-derived neurotrophic factor and motor function recovery: a rat brain ischemia model. (21347437)
2011
17
Transient middle cerebral artery occlusion in rats as an experimental model of brain ischemia. (20877953)
2010
18
Antioxidant CR-6 protects against reperfusion injury after a transient episode of focal brain ischemia in rats. (19904289)
2010
19
Study of the origin of short- and long-latency SSEP during recovery from brain ischemia in a rat model. (20816917)
2010
20
Fate and manipulations of endogenous neural stem cells following brain ischemia. (19653861)
2009
21
Reduction of brain infarction induced by a transient brain ischemia in mdr1a knockout mice. (19277863)
2009
22
PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia. (19384589)
2009
23
Association of protein kinase C delta and phospholipid scramblase 3 in hippocampal mitochondria correlates with neuronal vulnerability to brain ischemia. (19428821)
2009
24
Topiramate reduces non-convulsive seizures after focal brain ischemia in the rat. (18063309)
2008
25
Temporal changes in free iron levels after brain ischemia Relevance to the timing of iron chelation therapy in stroke. (18485533)
2008
26
Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions. (17157267)
2007
27
Differential changes in phosphorylation of tau at PHF-1 and 12E8 epitopes during brain ischemia and reperfusion in gerbils. (17191139)
2007
28
Rasagiline is neuroprotective in an experimental model of brain ischemia in the rat. (17177075)
2007
29
Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemia. (16498189)
2006
30
Magnesium sulphate reduces cell volume in physiological conditions but not in the cytotoxic oedema during global brain ischemia. (17060142)
2006
31
Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. (15686962)
2005
32
Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia. (15684564)
2005
33
Pathophysiology of brain ischemia: penumbra, gene expression, and future therapeutic options. (16352903)
2005
34
C1-inhibitor protects against brain ischemia-reperfusion injury via inhibition of cell recruitment and inflammation. (15837556)
2005
35
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study. (15716852)
2005
36
Manganese-enhanced magnetic resonance imaging (MEMRI) of brain activity and applications to early detection of brain ischemia. (15617055)
2004
37
An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia. (15489015)
2004
38
Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. (15161641)
2004
39
Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm. (14969736)
2004
40
Two types of calcium channels regulating activation of proline-rich tyrosine kinase 2 induced by transient brain ischemia in rat hippocampus. (12932810)
2003
41
Cooling and rewarming for brain ischemia or injury: theoretical analysis. (12680732)
2003
42
Modulation of IkappaB kinase autophosphorylation and activity following brain ischemia. (12676069)
2003
43
Resolved: Heparin may be useful in selected patients with brain ischemia. (12511779)
2003
44
Subcellular localization of a promoter and an inhibitor of apoptosis (Smac/DIABLO and XIAP) during brain ischemia/reperfusion. (12395105)
2002
45
Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin. (11166685)
2001
46
Effect of carnosine on rats under experimental brain ischemia. (10946918)
2000
47
Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis. (11105983)
2000
48
Brain metabolic and ionic responses to global brain ischemia in the newborn dog in vivo: 1. Methodological aspects. (10935225)
2000
49
Metabolic and ionic responses to global brain ischemia in the newborn dog in vivo: II. Post-natal age aspects. (11045028)
2000
50
Potential role of calcineurin for brain ischemia and traumatic injury. (10321795)
1999

Variations for Brain Ischemia

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Expression for genes affiliated with Brain Ischemia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Ischemia

Search GEO for disease gene expression data for Brain Ischemia.

Pathways for genes affiliated with Brain Ischemia

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 5Cell Signaling Technology
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Pathways related to Brain Ischemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8ADORA3, ADORA1
2
Show member pathways
citrulline-nitric oxide cycle39
arginine degradation I (arginase pathway)39
proline degradation39
glutamine degradation I39
proline biosynthesis I39
superpathway of citrulline metabolism39
proline biosynthesis II (from arginine)39
citrulline biosynthesis39
arginine degradation VI (arginase 2 pathway)39
Urea cycle and metabolism of amino groups39
asparagine biosynthesis I39
4-hydroxyproline degradation I39
citrulline degradation39
9.3NOS1, CKB
38.5NOS1, CAMK2G, MAP2
4
Show member pathways
8.3NOS1, CAMK2G, ADCY10, ADORA1

Compounds for genes affiliated with Brain Ischemia

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Sources:
30IUPHAR, 46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 3BitterDB, 25HMDB
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Compounds related to Brain Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1cp608,0393010.1ADORA3, ADORA1
2peneca3010.1ADORA3, ADORA1
3apadenoson3010.1ADORA1, ADORA3
4psb-113010.1ADORA1, ADORA3
5psb-103010.1ADORA3, ADORA1
6mrs51513010.1ADORA1, ADORA3
7psb11153010.1ADORA3, ADORA1
8(r,s)-phpneca3010.1ADORA1, ADORA3
92-hexynyl-neca3010.0ADORA1, ADORA3
10gs96673010.0ADORA1, ADORA3
11bay60-65833010.0ADORA1, ADORA3
12regadenoson46 30 1211.9ADORA1, ADORA3
13neca309.9ADORA3, ADORA1
14binodenoson46 3010.8ADORA3, ADORA1
15las38096309.8ADORA1, ADORA3
16atl802309.7ADORA1, ADORA3
17(r)-(phenylisopropyl)adenosine469.7ADCY10, ADORA3, ADORA1
185-n-ethylcarboxamidoadenosine469.7ADORA3, ADORA1, ADCY10
19cyclopentyladenosine309.5ADORA1, ADORA3
20ganglioside469.0GDNF, NES, MAP2, CAMK2G
21kainate46 309.7GDNF, ADORA1, NES, MAP2, CAMK2G
22carbachol46 30 1210.7NOS1, ADORA1, ADCY10, CAMK2G
235-hydroxytryptamine468.6ADORA1, ADCY10, NOS1, CAMK2G
24forskolin46 52 1210.6GDNF, CKB, CAMK2G, ADCY10, ADORA3
25isoproterenol46 129.6ADORA1, ADCY10, CAMK2G, NOS1
26aspartate468.4GDNF, ADORA1, CKB, EIF2AK3, NOS1
27genistein46 30 62 3 25 1213.4GDNF, ADCY10, ADORA3, NOS1, ADORA1
28histamine46 30 2510.3CAMK2G, NOS1, ADCY10, ADORA1, ADORA3
29potassium46 25 1210.3CAMK2G, GDNF, MAP2, ADORA1, ADORA3, CKB
30choline46 25 1210.2GDNF, MAP2, NES, NOS1, CAMK2G
31cocaine46 129.1NOS1, CAMK2G, MAP2, ADORA1, GDNF
32nmda46 309.1CAMK2G, NOS1, ADORA1, GDNF, MAP2
33phosphoinositide468.1ADCY10, MAP2, CAMK2G, ADORA1, ADORA3, GDNF
34dexamethasone46 52 30 1211.1NOS1, ADCY10, ADORA1, GDNF, CAMK2G
35superoxide46 259.1ADORA3, MAP2, CAMK2G, NOS1, GDNF
36vegf468.0NOS1, GDNF, NES, CAMK2G, MAP2
37acetylcholine46 52 30 25 1212.0ADCY10, ADORA1, NES, GDNF, CAMK2G, NOS1
38alanine467.9NOS1, EIF2AK3, CKB, ADORA1, GDNF, CAMK2G
39nitric oxide46 25 129.9MAP2, ADORA3, NES, EIF2AK3, NOS1, GDNF
40glucose467.9EIF2AK3, CAMK2G, ADORA3, NES, GDNF, CKB
41atp46 308.8ADORA3, ADORA1, CAMK2G, MAP2, GDNF, CKB
42cyclic amp46 258.8ADCY10, GDNF, ADORA3, ADORA1, MAP2, CKB
43norepinephrine46 25 129.6NOS1, MAP2, GDNF, ADORA1, ADCY10, CAMK2G
44gaba467.5ADORA1, GDNF, MAP2, CAMK2G, NOS1, NES
45dopamine46 30 25 1210.4ADCY10, NES, GDNF, MAP2, CAMK2G, NOS1
46adenylate467.3ADORA3, MAP2, CAMK2G, NOS1, ADCY10, ADORA1
47estrogen467.3CKB, EIF2AK3, MAP2, ADORA1, ADORA3, NES
48oxygen46 258.1GDNF, CKB, CAMK2G, MAP2, ADORA3, EIF2AK3
49glutamate467.0ADORA1, GDNF, ADCY10, MAP2, CAMK2G, NES
50calcium46 52 25 129.5CAMK2G, ADORA3, GDNF, MAP2, ADCY10, ADORA1

GO Terms for genes affiliated with Brain Ischemia

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Sources:
17Gene Ontology
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Cellular components related to Brain Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.0MAP2, ADCY10, ADORA1

Biological processes related to Brain Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin secretionGO:0300739.2EIF2AK3, CAMK2G
2negative regulation of blood pressureGO:0457769.2NOS1, ADORA1
3nervous system developmentGO:0073999.2CAMK2G, ADORA1, GDNF

Molecular functions related to Brain Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled adenosine receptor activityGO:0016099.5ADORA1, ADORA3
2calmodulin bindingGO:0055168.5NOS1, CAMK2G, MAP2

Products for genes affiliated with Brain Ischemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brain Ischemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet