Aliases & Classifications for Brain Ischemia

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Brain Ischemia, Aliases & Descriptions:

Name: Brain Ischemia 30 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Summaries for Brain Ischemia

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Wikipedia:63 Brain ischemia (aka cerebral ischemia, cerebrovascular ischemia) is a condition in which there is... more...

MalaCards based summary: Brain Ischemia is related to ischemia and schizophrenia. An important gene associated with Brain Ischemia is NES (nestin), and among its related pathways are Nucleotide-like (purinergic) receptors and Arginine and proline metabolism. The drugs etomidate and papaverine and the compounds cp608,039 and (r,s)-phpneca have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and monocytes, and related mouse phenotypes are no phenotypic analysis and renal/urinary system.

Related Diseases for Brain Ischemia

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Diseases related to Brain Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.3NOS1, EIF2AK3, CKB, MAP2, ADORA1, ADORA3
2schizophrenia29.3ADCY10, NOS1, MAP2, GDNF
3neuronitis10.9
4cerebritis10.7
5hypoxia10.5
6brain injury10.4
7ganglioglioma10.3MAP2
8cerebral artery occlusion10.3
9pyloric stenosis10.2NOS1
10hyperglycemia10.2
11endotheliitis10.2
12spinocerebellar ataxia10.2MAP2, CKB
13atrial fibrillation10.2CAMK2G, ADORA1
14traumatic brain injury10.1
15vascular dementia10.1
16angioedema10.1
17dementia10.1
18protein-energy malnutrition10.1
19ependymoma10.1NES, MAP2
20stroke, ischemic10.1GDNF, NES
21congenital heart disease10.1ADCY10, CKB
22multiple system atrophy10.1MAP2, GDNF
23tuberous sclerosis10.1NES, MAP2
24pituitary adenoma10.1GDNF, ADCY10, NES
25temporal lobe epilepsy10.0GDNF, ADORA1, CAMK2G
26hirschsprung disease 110.0NOS1, GDNF
27transient cerebral ischemia10.0ADORA1, MAP2, CAMK2G
28atherosclerosis10.0
29hepatitis10.0
30hyperhomocysteinemia10.0
31hypoglycemia10.0
32brain edema10.0
33artery disease10.0
34carotid artery disease10.0
35ehlers-danlos syndrome10.0
36herpes simplex10.0
37mitochondrial cardiomyopathy10.0
38aneurysm10.0
39anoxia10.0
40myoclonus10.0
41brain cancer10.0GDNF, MAP2, NES
42cystic fibrosis10.0ADORA1, CAMK2G, ADCY10
43toxic encephalopathy9.9GDNF, MAP2
44duchenne muscular dystrophy9.9GDNF, NOS1
45pheochromocytoma9.9GDNF, MAP2, ADCY10
46factor v leiden thrombophilia9.9ADCY10, NOS1, NES
47vascular disease9.8ADORA1, NOS1, MAP2
48bipolar disorder9.8GDNF, MAP2, NOS1
49small cell cancer of the lung, somatic9.8CKB, MAP2, GDNF, ADCY10
50amyotrophic lateral sclerosis 19.7MAP2, NOS1, NES, GDNF

Graphical network of the top 20 diseases related to Brain Ischemia:



Diseases related to brain ischemia

Symptoms for Brain Ischemia

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Drugs & Therapeutics for Brain Ischemia

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Drug clinical trials:

Search ClinicalTrials for Brain Ischemia

Search NIH Clinical Center for Brain Ischemia

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Ischemia:
Mesenchymal stem cell-derived neuronal progenitor cells for the treatment of ischemic brain damage
Embryonic/Adult Cultured Cells Related to Brain Ischemia:
Neural progenitor cells, PMID: 21300404

Genetic Tests for Brain Ischemia

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Anatomical Context for Brain Ischemia

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MalaCards organs/tissues related to Brain Ischemia:

31
Brain, Cortex, Monocytes, Endothelial, Bone marrow, Bone, Neutrophil, Heart, Liver, Prefrontal cortex, Pituitary

Animal Models for Brain Ischemia or affiliated genes

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MGI Mouse Phenotypes related to Brain Ischemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4NOS1, EIF2AK3, CAMK2G, ADORA3
2MP:00053678.2GDNF, ADORA3, ADORA1, NOS1
3MP:00053857.9GDNF, ADORA3, ADORA1, ADCY10, NOS1
4MP:00053897.6GDNF, ADCY10, MAP2, CAMK2G, NOS1
5MP:00053787.6GDNF, NES, MAP2, CKB, EIF2AK3, NOS1
6MP:00053767.5ADORA3, ADORA1, ADCY10, CAMK2G, EIF2AK3, NOS1
7MP:00036317.3GDNF, NES, ADORA1, MAP2, CKB, EIF2AK3
8MP:00053867.0NOS1, GDNF, NES, ADORA3, ADORA1, MAP2

Publications for Brain Ischemia

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Articles related to Brain Ischemia:

(show top 50)    (show all 551)
idTitleAuthorsYear
1
Unfolding the Unfolded Protein Response: Unique Insights into Brain Ischemia. (25830481)
2015
2
Real-time trafficking of PEGylated liposomes in the rodent focal brain ischemia analyzed by positron emission tomography. (25295359)
2014
3
Neuroprotective effects of histone deacetylase inhibitors in brain ischemia. (25576969)
2014
4
Neuroprotective effects of crocin on the histopathological alterations following brain ischemia-reperfusion injury in rat. (25691932)
2014
5
Onset of Orolingual Angioedema After Treatment of Acute Brain Ischemia with Alteplase Depends on the Site of Brain Ischemia: A Meta-analysis. (24350070)
2013
6
Effects of vinpocetine and ozagrel on behavioral recovery of rats after global brain ischemia. (24291485)
2013
7
Phosphorylation of tau protein over time in rats subjected to transient brain ischemia. (25206638)
2013
8
Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neurons. (23355003)
2013
9
Protein misfolding, aggregation, and autophagy after brain ischemia. (24323413)
2013
10
DCX-expressing neurons decrease in the retrosplenial cortex after global brain ischemia. (22879023)
2013
11
Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction. (22158864)
2012
12
Eag1, Eag2, and SK3 potassium channel expression in the rat hippocampus after global transient brain ischemia. (22006722)
2012
13
Texture analysis of poly-adenylated mRNA staining following global brain ischemia and reperfusion. (21477879)
2012
14
Phenolic alkaloids from Menispermum dauricum rhizome protect against brain ischemia injury via regulation of GLT-1, EAAC1 and ROS generation. (22395403)
2012
15
Brain ischemia, neurogenesis, and neurotrophic receptor expression in primates. (21701994)
2011
16
'Functional histology' in brain ischemia studies. (21448216)
2011
17
Zinc: new clues to diverse roles in brain ischemia. (21621864)
2011
18
The protective effect of avocado soybean unsaponifilables on brain ischemia/reperfusion injury in rat prefrontal cortex. (20874457)
2011
19
Brain ischemia and hypometabolism treated by ozone therapy. (22105041)
2011
20
The effects of voluntary, involuntary, and forced exercises on brain-derived neurotrophic factor and motor function recovery: a rat brain ischemia model. (21347437)
2011
21
Transient middle cerebral artery occlusion in rats as an experimental model of brain ischemia. (20877953)
2010
22
Antioxidant CR-6 protects against reperfusion injury after a transient episode of focal brain ischemia in rats. (19904289)
2010
23
Fate and manipulations of endogenous neural stem cells following brain ischemia. (19653861)
2009
24
Reduction of brain infarction induced by a transient brain ischemia in mdr1a knockout mice. (19277863)
2009
25
PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia. (19384589)
2009
26
Association of protein kinase C delta and phospholipid scramblase 3 in hippocampal mitochondria correlates with neuronal vulnerability to brain ischemia. (19428821)
2009
27
Topiramate reduces non-convulsive seizures after focal brain ischemia in the rat. (18063309)
2008
28
Temporal changes in free iron levels after brain ischemia Relevance to the timing of iron chelation therapy in stroke. (18485533)
2008
29
Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions. (17157267)
2007
30
Differential changes in phosphorylation of tau at PHF-1 and 12E8 epitopes during brain ischemia and reperfusion in gerbils. (17191139)
2007
31
Rasagiline is neuroprotective in an experimental model of brain ischemia in the rat. (17177075)
2007
32
Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemia. (16498189)
2006
33
Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. (15686962)
2005
34
Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia. (15684564)
2005
35
Pathophysiology of brain ischemia: penumbra, gene expression, and future therapeutic options. (16352903)
2005
36
C1-inhibitor protects against brain ischemia-reperfusion injury via inhibition of cell recruitment and inflammation. (15837556)
2005
37
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study. (15716852)
2005
38
Manganese-enhanced magnetic resonance imaging (MEMRI) of brain activity and applications to early detection of brain ischemia. (15617055)
2004
39
An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia. (15489015)
2004
40
Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. (15161641)
2004
41
Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm. (14969736)
2004
42
Two types of calcium channels regulating activation of proline-rich tyrosine kinase 2 induced by transient brain ischemia in rat hippocampus. (12932810)
2003
43
Cooling and rewarming for brain ischemia or injury: theoretical analysis. (12680732)
2003
44
Subcellular localization of a promoter and an inhibitor of apoptosis (Smac/DIABLO and XIAP) during brain ischemia/reperfusion. (12395105)
2002
45
Perfusion mapping using computed tomography allows accurate prediction of cerebral infarction in experimental brain ischemia. (11136934)
2001
46
Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin. (11166685)
2001
47
Effect of carnosine on rats under experimental brain ischemia. (10946918)
2000
48
Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis. (11105983)
2000
49
Brain metabolic and ionic responses to global brain ischemia in the newborn dog in vivo: 1. Methodological aspects. (10935225)
2000
50
Potential role of calcineurin for brain ischemia and traumatic injury. (10321795)
1999

Variations for Brain Ischemia

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Expression for genes affiliated with Brain Ischemia

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Search GEO for disease gene expression data for Brain Ischemia.

Pathways for genes affiliated with Brain Ischemia

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Pathways related to Brain Ischemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8ADORA3, ADORA1
2
Show member pathways
citrulline-nitric oxide cycle36
arginine degradation I (arginase pathway)36
proline degradation36
glutamine degradation I36
proline biosynthesis I36
superpathway of citrulline metabolism36
proline biosynthesis II (from arginine)36
citrulline biosynthesis36
arginine degradation VI (arginase 2 pathway)36
Urea cycle and metabolism of amino groups36
asparagine biosynthesis I36
4-hydroxyproline degradation I36
citrulline degradation36
9.3NOS1, CKB
38.5NOS1, CAMK2G, MAP2
4
Show member pathways
8.3NOS1, CAMK2G, ADCY10, ADORA1

Compounds for genes affiliated with Brain Ischemia

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Compounds related to Brain Ischemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1cp608,0392810.1ADORA1, ADORA3
2(r,s)-phpneca2810.1ADORA1, ADORA3
3psb11152810.1ADORA3, ADORA1
4peneca2810.1ADORA1, ADORA3
5psb-112810.1ADORA3, ADORA1
6psb-102810.1ADORA1, ADORA3
7mrs51512810.1ADORA1, ADORA3
8apadenoson2810.1ADORA3, ADORA1
9mrs35582810.0ADORA1, ADORA3
10sch 5826159 2811.0ADORA3, ADORA1
11fk-4532810.0ADORA3, ADORA1
12hemado289.9ADORA3, ADORA1
138-(p-sulfophenyl)theophylline439.9ADORA3, ADORA1
14st-1535289.8ADORA1, ADORA3
15mre 3008f20289.8ADORA1, ADORA3
16cgs 21680289.7ADORA1, ADORA3
17(r)-(phenylisopropyl)adenosine439.7ADCY10, ADORA3, ADORA1
185-n-ethylcarboxamidoadenosine439.7ADORA3, ADORA1, ADCY10
19rolofylline289.5ADORA1, ADORA3
20ganglioside439.0GDNF, NES, MAP2, CAMK2G
21kainate43 289.7GDNF, ADORA1, NES, MAP2, CAMK2G
22carbachol43 28 1210.7ADORA1, ADCY10, CAMK2G, NOS1
235-hydroxytryptamine438.6CAMK2G, ADORA1, ADCY10, NOS1
24forskolin43 49 1210.6ADCY10, CAMK2G, CKB, ADORA3, GDNF
25isoproterenol43 129.6NOS1, CAMK2G, ADORA1, ADCY10
26aspartate438.4ADORA1, EIF2AK3, NOS1, CKB, GDNF
27genistein43 28 59 2 24 1213.4ADORA3, ADORA1, ADCY10, NOS1, GDNF
28histamine43 28 2410.3ADCY10, CAMK2G, ADORA1, ADORA3, NOS1
29potassium43 24 1210.3CAMK2G, GDNF, MAP2, ADORA1, ADORA3, CKB
30choline43 24 1210.2GDNF, MAP2, NES, NOS1, CAMK2G
31cocaine43 129.1NOS1, CAMK2G, MAP2, ADORA1, GDNF
32nmda43 289.1CAMK2G, NOS1, ADORA1, GDNF, MAP2
33phosphoinositide438.1ADCY10, MAP2, CAMK2G, ADORA1, ADORA3, GDNF
34dexamethasone43 49 28 1211.1CAMK2G, GDNF, ADORA1, ADCY10, NOS1
35superoxide43 249.1ADORA3, MAP2, CAMK2G, NOS1, GDNF
36vegf438.0CAMK2G, MAP2, NOS1, GDNF, NES
37acetylcholine43 49 28 24 1212.0ADCY10, ADORA1, NES, GDNF, CAMK2G, NOS1
38alanine437.9CKB, GDNF, NOS1, EIF2AK3, CAMK2G, ADORA1
39nitric oxide43 24 129.9EIF2AK3, MAP2, ADORA3, NOS1, NES, GDNF
40glucose437.9EIF2AK3, CAMK2G, ADORA3, NES, GDNF, CKB
41atp43 288.8ADORA3, ADORA1, CAMK2G, MAP2, GDNF, CKB
42cyclic amp43 248.8ADCY10, GDNF, ADORA3, ADORA1, MAP2, CKB
43norepinephrine43 24 129.6NOS1, MAP2, GDNF, ADORA1, ADCY10, CAMK2G
44gaba437.5ADORA1, GDNF, MAP2, CAMK2G, NOS1, NES
45dopamine43 28 24 1210.4ADCY10, NES, GDNF, MAP2, CAMK2G, NOS1
46adenylate437.3ADORA3, MAP2, CAMK2G, NOS1, ADCY10, ADORA1
47estrogen437.3CKB, EIF2AK3, MAP2, ADORA1, ADORA3, NES
48oxygen43 248.1GDNF, CKB, CAMK2G, MAP2, ADORA3, EIF2AK3
49glutamate437.0ADORA1, GDNF, ADCY10, MAP2, CAMK2G, NES
50calcium43 49 24 129.5CAMK2G, ADORA3, GDNF, MAP2, ADCY10, ADORA1

GO Terms for genes affiliated with Brain Ischemia

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Cellular components related to Brain Ischemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430259.0MAP2, ADCY10, ADORA1

Biological processes related to Brain Ischemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin secretionGO:00300739.2EIF2AK3, CAMK2G
2negative regulation of blood pressureGO:00457769.2NOS1, ADORA1
3nervous system developmentGO:00073999.2CAMK2G, ADORA1, GDNF

Molecular functions related to Brain Ischemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1G-protein coupled adenosine receptor activityGO:00016099.5ADORA1, ADORA3
2calmodulin bindingGO:00055168.5NOS1, CAMK2G, MAP2

Products for genes affiliated with Brain Ischemia

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Sources for Brain Ischemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet