MCID: BRN080
MIFTS: 40

Brain Ischemia

Categories: Neuronal diseases

Aliases & Classifications for Brain Ischemia

MalaCards integrated aliases for Brain Ischemia:

Name: Brain Ischemia 38 52 69

Classifications:



Summaries for Brain Ischemia

MalaCards based summary : Brain Ischemia is related to ischemia and sella turcica neoplasm. An important gene associated with Brain Ischemia is KCNB1 (Potassium Voltage-Gated Channel Subfamily B Member 1), and among its related pathways/superpathways are Melatonin metabolism and effects and Photodynamic therapy-induced HIF-1 survival signaling. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include Brain and Brain.

Wikipedia : 72 Brain ischemia (a.k.a. cerebral ischemia, cerebrovascular ischemia) is a condition in which there is... more...

Related Diseases for Brain Ischemia

Diseases related to Brain Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
id Related Disease Score Top Affiliating Genes
1 ischemia 10.9
2 sella turcica neoplasm 10.6 GFAP NES
3 anaplastic plasmacytoma 10.6 GFAP NES
4 macular retinal edema 10.6 GFAP NES
5 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.6 GFAP NES
6 brain glioma 10.6 GFAP NES
7 aggressive systemic mastocytosis 10.5 GFAP NES
8 axonal neuropathy 10.5 GFAP NES
9 space motion sickness 10.5 GFAP NES
10 sudden sensorineural hearing loss 10.5 GFAP NES
11 brain stem ependymoma 10.5 GFAP NES
12 pediatric ependymoma 10.5 GFAP NES
13 lymphopenia 10.5 GFAP NES
14 mixed epithelial stromal tumour 10.5 GFAP NES
15 cold-induced sweating syndrome 3 10.4 GFAP NES
16 chilaiditi syndrome 10.4 GFAP MAP2
17 hemoglobinemia 10.4 GFAP MAP2
18 neuronitis 10.4
19 epidermolysa bullosa simplex with muscular dystrophy 10.4 GFAP NES
20 gliofibroma 10.4 GFAP MAP2
21 skin hemangioma 10.3 GFAP NES
22 microcephaly, amish type 10.3 MAP2 NES
23 large intestine lipoma 10.3 GFAP MAP2
24 vestibular disease 10.3 MAP2 NES
25 overuse syndrome 10.3 MAP2 NES
26 toxic pneumonitis 10.3 GFAP MAP2
27 intracranial arteriosclerosis 10.2 NES NOS2
28 levator syndrome 10.2 NES NOS2
29 cerebritis 10.2
30 hypoglossal nerve neoplasm 10.2 GFAP NES
31 adenofibroma 10.1 GFAP MAP2 NES
32 calcific tendinitis 10.1 GFAP MAP2 NES
33 eyelid degenerative disease 10.1 HSPA8 NOS2
34 cervical benign neoplasm 10.1 GFAP MAP2 NES
35 cervical adenomyoma 10.1 GFAP MAP2 NES
36 sternum cancer 10.1 GFAP MAP2 NES
37 esophageal leukoplakia 10.0 EDN1 NOS2
38 spinal stenosis 10.0 GFAP NOS2
39 hypoxia 10.0
40 papillary hidradenoma 9.9 GFAP MAP2
41 brain injury 9.9
42 cerebral artery occlusion 9.8
43 silver-russell syndrome due to 11p15 microduplication 9.8 ADCY10 EDN1
44 cardiac arrest 9.8
45 glioblastoma 3 9.7 GFAP MAP2 NES
46 hyperglycemia 9.7
47 endotheliitis 9.7
48 vascular dementia 9.6
49 protein-energy malnutrition 9.6
50 carotid stenosis 9.6

Graphical network of the top 20 diseases related to Brain Ischemia:



Diseases related to Brain Ischemia

Symptoms & Phenotypes for Brain Ischemia

Drugs & Therapeutics for Brain Ischemia

Drugs for Brain Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 526)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 4,Phase 3 59-92-7 6047
3
Ephedrine Approved Phase 4,Phase 2 299-42-3 9294
4
Oxymetazoline Approved Phase 4,Phase 2 1491-59-4 4636
5
Phenylephrine Approved Phase 4,Phase 2 59-42-7 6041
6
Pseudoephedrine Approved Phase 4,Phase 2 90-82-4 7028
7
Atenolol Approved Phase 4 29122-68-7 2249
8
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
9
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
10
Nimodipine Approved Phase 4 66085-59-4 4497
11
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 772 46507594
12 Nadroparin Approved Phase 4 9041-08-1
13
Zinc Approved Phase 4,Phase 2,Phase 3,Phase 1 7440-66-6 32051 23994
14
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-78-2 2244
15
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55142-85-3 5472
16
Menthol Approved Phase 4,Phase 2,Phase 1 2216-51-5 16666
17
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 7487-88-9 24083
18
Cilostazol Approved Phase 4,Phase 3 73963-72-1 2754
19
Dalteparin Approved Phase 4,Phase 2 9005-49-6
20
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
21
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2 437-38-7 3345
22
Apixaban Approved Phase 4,Phase 3,Phase 2 503612-47-3 10182969
23 Edoxaban Approved Phase 4,Phase 2,Phase 3 480449-70-5
24
Rivaroxaban Approved Phase 4,Phase 3,Phase 2 366789-02-8
25
Warfarin Approved Phase 4,Phase 2,Phase 3 81-81-2 6691 54678486
26
Allopurinol Approved Phase 4,Phase 3 315-30-0 2094
27
Acenocoumarol Approved Phase 4 152-72-7 9052 54676537
28
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
29
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
30
Midazolam Approved, Illicit Phase 4,Phase 2 59467-70-8 4192
31 Piracetam Approved Phase 4,Phase 2 7491-74-9
32
Dipyridamole Approved Phase 4,Phase 3,Phase 2 58-32-2 3108
33
Antipyrine Approved Phase 4,Phase 3,Phase 2 60-80-0 2206
34
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
35
Amlodipine Approved Phase 4,Phase 2 88150-42-9 2162
36
Losartan Approved Phase 4,Phase 3 114798-26-4 3961
37
Triflusal Approved Phase 4 322-79-2
38
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3 51-43-4 5816
39 Racepinephrine Approved Phase 4,Phase 2,Phase 3
40
Probucol Approved Phase 4 23288-49-5 4912
41
Argatroban Approved, Investigational Phase 4,Phase 2 74863-84-6 152951
42
Thrombin Approved Phase 4
43
Desflurane Approved Phase 4 57041-67-5 42113
44
Isoflurane Approved, Vet_approved Phase 4,Phase 2,Phase 3 26675-46-7 3763
45
Remifentanil Approved Phase 4 132875-61-7 60815
46
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
47
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
48
Levobupivacaine Approved Phase 4 27262-47-1 92253
49
Pravastatin Approved Phase 4,Phase 3 81093-37-0 54687
50
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878

Interventional clinical trials:

(show top 50) (show all 1180)

id Name Status NCT ID Phase Drugs
1 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
2 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
3 Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery Unknown status NCT01794273 Phase 4 ephedrine and phenylephrine
4 Comprehensive Reparative Therapy in Ischemic Stroke COMplex Repair in Ischemic Stroke-Arm Unknown status NCT02581371 Phase 4 Cerebrolysin infusion
5 Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol Unknown status NCT02403349 Phase 4 Fimasartan;Valsartan;Atenolol
6 Nimodipine for Treating Acute Massive Cerebral Infarction Unknown status NCT02248233 Phase 4 Nimodipine;Saline + citicoline
7 Safety and Efficacy of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke Unknown status NCT01862978 Phase 4 Heparin;Nadroparin;Placebo
8 Valsartan Efficacy on Modest Blood Pressure Reduction in Acute Ischemic Stroke Unknown status NCT00874601 Phase 4 Diovan® (valsartan)
9 Efficacy Study of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke Unknown status NCT01758536 Phase 4 Huatuo Zaizao Pills
10 Comparison of Two Strategies for Glycemic Control in Acute Ischemic Stroke Unknown status NCT00747279 Phase 4 Intensive insulin therapy
11 Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy Unknown status NCT01097967 Phase 4
12 The Effect of Erigeron Injection on Acute Cerebral Infarction Serum VEGF, MMP-9 and EPC Levels Unknown status NCT01926834 Phase 4 Erigeron Injection;placebo
13 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4 Butylphthalide Soft Capsules;Aspirin
14 The Dynamic Effect of Non-cytochrome P450 Isoenzyme 3A4(CYP3A4)-Metabolized and Cytochrome P450 Isoenzyme 3A4(CYP3A4)-Metabolized Statins on Clopidogrel Resistance in Patients With Cerebral Infarction Unknown status NCT02411903 Phase 4 atorvastatin and clopidogrel;rosuvastatin and clopidogrel
15 Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia Unknown status NCT00247533 Phase 4
16 Efficacy and Safety Study of Nimodipine to Prevent Mild Cognitive Impairment After Acute Ischemic Strokes Unknown status NCT01220622 Phase 4 Nimodipine;Placebo
17 The Role of Statins in Preventing Cerebral Vasospasm Secondary to Subarachnoid Hemorrhage Unknown status NCT01346748 Phase 4 statin
18 Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
19 A Clinical Trial of Danhong Injection in Treating Acute Ischemic Stroke Unknown status NCT02152280 Phase 4 Danhong Injection;Normal Saline
20 Multi-"Omics" Research of Danhong Injection to Treat Acute Ischemic Stroke Unknown status NCT02176395 Phase 4 Danhong injection;placebo
21 Resuvastatin Treatment for Symptomatic Middle Cerebral Artery Stenosis Based on High-resolution Magnetic Resonance Imaging Unknown status NCT02041117 Phase 4 Rosuvastatin
22 Single High Dose Vitamin C, E in Severe Birth Asphyxia Completed NCT01743742 Phase 4 Vitamin E, Vitamin C
23 ESPRIT: European/Australasian Stroke Prevention in Reversible Ischaemia Trial Completed NCT00161070 Phase 4 anticoagulation;aspirin and dipyridamole;aspirin alone
24 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4 magnesium
25 Post-marketing Clinical Study of Alteplase for Acute Ischemic Stroke (Japan Alteplase Clinical Trial Ⅱ:J-ACT Ⅱ) Completed NCT00412867 Phase 4 Alteplase
26 The Effect of Cilostazol Compared to Aspirin on Endothelial Function in Acute Cerebral Ischemia Patients Completed NCT03116269 Phase 4 Cilostazol 100mg;Aspirin
27 The Effect of Ventilation on Cerebral Oxygenation in the Sitting Position Completed NCT01546636 Phase 4
28 Cilostazol in Acute Ischemic Stroke Treatment (CAIST) Completed NCT00272454 Phase 4 Cilostazol;Aspirin
29 AISTCM-Outcome Measurement of Acute Ischemic Stroke With Traditional Chinese Medicine Completed NCT00351806 Phase 4 Erigeron breviscapus injection;hua tuo zai zao wan (a herbal medicine pill);Compound stroke herbal medicine (8 herbal)
30 Merci Registry - Real World Use of the Merci Retrieval System in Acute Ischemic Stroke Completed NCT00478478 Phase 4
31 Edaravone-Sodium Ozagrel Comparative Post-Marketing Study on Acute Ischemic Stroke Completed NCT00200356 Phase 4 Edaravone;Sodium Ozagrel
32 The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED) Completed NCT00754429 Phase 4 losartan;amlodipine
33 Atorvastatin in Acute Stroke Treatment Completed NCT02225834 Phase 4 Atorvastatin
34 Safety and Efficacy of Clopidogrel for Cerebral Infarction Treatment Completed NCT00386191 Phase 4 clopidogrel (SR25990C)
35 Comparison of Triflusal and Clopidogrel in Secondary Prevention of Stroke Based on the Genotyping Completed NCT01174693 Phase 4 Triflusal;Clopidogrel
36 Overcome Biochemical Aspirin Resistance Through Cilostazol Combination Completed NCT00446641 Phase 4 Cilostazol;placebo
37 The Study on Profile and Genetic Factors of Aspirin Resistance (ProGEAR Study) Completed NCT00250380 Phase 4
38 Thrombectomy REvascularization of Large Vessel Occlusions in Acute Ischemic Stroke (TREVO) Completed NCT01088672 Phase 4
39 Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) Completed NCT00234065 Phase 4 Cilostazol;Aspirin
40 Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke Completed NCT01762163 Phase 4 Qizhitongluo Capsule;Naoxintong Capsule;Aspirin Enteric-coated Tablets;placebo
41 Establishment and Evaluation to the Effects of a Clinical Pathway for Acute Ischemic Stroke Completed NCT00966316 Phase 4 aspirin,chinese herbs;
42 A Safety Study of Ginkgolides Meglumine Injection in the Treatment of Ischemic Stroke. Completed NCT01958957 Phase 4 Ginkgolides Meglumine Injection
43 Tongxinluo Capsule in Ischemic Stroke Patients(TISS) Completed NCT01919671 Phase 4 Tongxinluo capsule;placebo capsule
44 The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke Completed NCT00868283 Phase 4 Cerebrolysin;0.9% Saline Solution
45 Quality Improvement in Stroke Prevention (QUISP) Completed NCT00328640 Phase 4 Optimal treatment
46 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
47 PREVAIL: PREvention of VTE After Acute Ischemic Stroke With LMWH Enoxaparin ( - VTE: Venous Thromboembolism - LMWH: Low Molecular Weight Heparin) Completed NCT00077805 Phase 4 Enoxaparin sodium
48 Platelet Hyperreactivity to Aspirin and Stroke Completed NCT00766896 Phase 4 Aspirin (platelet sensitive versus platelet hyperreactivity)
49 Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis II Completed NCT00130039 Phase 4 clopidogrel;Cilostazol
50 Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke Completed NCT01109836 Phase 4

Search NIH Clinical Center for Brain Ischemia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Ischemia:
Mesenchymal stem cell-derived neuronal progenitor cells for the treatment of ischemic brain damage
Embryonic/Adult Cultured Cells Related to Brain Ischemia:
Neural progenitor cells PMIDs: 21300404

Genetic Tests for Brain Ischemia

Anatomical Context for Brain Ischemia

MalaCards organs/tissues related to Brain Ischemia:

39
Brain, Heart, Bone, Liver, Endothelial, Bone Marrow, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Brain Ischemia:
id Tissue Anatomical CompartmentCell Relevance
1 Brain Forebrain White Matter Fibrous Astrocyte Cells Potential therapeutic candidate
2 Brain Neocortex Protoplasmic Astrocyte Cells Potential therapeutic candidate

Publications for Brain Ischemia

Articles related to Brain Ischemia:

(show top 50) (show all 639)
id Title Authors Year
1
Shifting Perceptions of Risk and Reward: Use of Anticoagulation in Patients With Acute Brain Ischemia and Atrial Fibrillation: Nine-Year Data From a National Acute Stroke Registry (National Acute Stroke Israeli Survey [NASIS]). ( 28258255 )
2017
2
Semi-synthetic sapogenin exerts neuroprotective effects by skewing the brain ischemia reperfusion transcriptome towards inflammatory resolution. ( 28390980 )
2017
3
Reverse electron transfer results in a loss of flavin from mitochondrial complex I: Potential mechanism for brain ischemia reperfusion injury. ( 28914132 )
2017
4
Combined l-citrulline and glutathione administration prevents neuronal cell death following transient brain ischemia. ( 28315310 )
2017
5
Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia. ( 28053883 )
2017
6
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. ( 28642575 )
2017
7
Longitudinal Assessments of Normal and Perilesional Tissues in Focal Brain Ischemia and Partial Optic Nerve Injury with Manganese-enhanced MRI. ( 28230106 )
2017
8
LOTUS overexpression accelerates neuronal plasticity after focal brain ischemia in mice. ( 28880879 )
2017
9
The effects of Y-27632 on pial microvessels during global brain ischemia and reperfusion in rabbits. ( 28270098 )
2017
10
A new threshold of apparent diffusion coefficient values in white matter after successful tissue plasminogen activator treatment for acute brain ischemia. ( 28187865 )
2017
11
Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. ( 28431607 )
2017
12
Brain Ischemia Suppresses Immunity in the Periphery and Brain via Different Neurogenic Innervations. ( 28314594 )
2017
13
Nontraditional Lipid Variables Predict Recurrent Brain Ischemia in Embolic Stroke of Undetermined Source. ( 28412318 )
2017
14
Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia. ( 28843543 )
2017
15
Early Reperfusion After Brain Ischemia Has Beneficial Effects Beyond Rescuing Neurons. ( 28626056 )
2017
16
Quinolinyl Nitrone RP19 Induces Neuroprotection after Transient Brain Ischemia. ( 28731692 )
2017
17
Glutamate dehydrogenase as a neuroprotective target against brain ischemia and reperfusion. ( 27845178 )
2017
18
Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation. ( 28360842 )
2017
19
G6PD plays a neuroprotective role in brain ischemia through promoting pentose phosphate pathway. ( 28823591 )
2017
20
Microglia-mediated BAFF-BAFFR ligation promotes neuronal survival in brain ischemia injury. ( 28918255 )
2017
21
Profiling and identification of new proteins involved in brain ischemia using MALDI-imaging-mass-spectrometry. ( 27888142 )
2017
22
The T-type calcium channel enhancer SAK3 inhibits neuronal death following transient brain ischemia via nicotinic acetylcholine receptor stimulation. ( 28457878 )
2017
23
Stress Granule Induction after Brain Ischemia Is Independent of Eukaryotic Translation Initiation Factor (eIF) 2I+ Phosphorylation and Is Correlated with a Decrease in eIF4B and eIF4E Proteins. ( 27836976 )
2016
24
Hyperbaric oxygen modalities are differentially effective in distinct brain ischemia models. ( 27826422 )
2016
25
Early Glycogen Synthase Kinase-3I^ (GSK-3I^) and Protein Phosphatase 2A (PP2A) independent tau dephosphorylation during global brain ischemia and reperfusion following cardiac arrest and the role of the Adenosine Monophosphate Kinase (AMPK) pathway. ( 27177932 )
2016
26
History of the Letzte Wiese/Last Meadow Concept of Brain Ischemia. ( 26757752 )
2016
27
Estrogen replacement therapy-induced neuroprotection against brain ischemia-reperfusion injury involves the activation of astrocytes via estrogen receptor I^. ( 26891996 )
2016
28
Discrepancy in Expression of I^-Secretase and Amyloid-I^ Protein Precursor in Alzheimer-Related Genes in the Rat Medial Temporal Lobe Cortex Following Transient Global Brain Ischemia. ( 26890784 )
2016
29
Butylphthalide Suppresses Neuronal Cells Apoptosis and Inhibits JNK-Caspase3 Signaling Pathway After Brain Ischemia /Reperfusion in Rats. ( 27015680 )
2016
30
Stress-responsive heme oxygenase-1 isoenzyme participates in Toll-like receptor 4-induced inflammation during brain ischemia. ( 26966782 )
2016
31
An integrated neuroprotective intervention for brain ischemia validated by ECoG-fPAM. ( 28269164 )
2016
32
Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia. ( 27656217 )
2016
33
Apoptosis and Acute Brain Ischemia in Ischemic Stroke. ( 27823556 )
2016
34
Interaction of ARC and Daxx: A Novel Endogenous Target to Preserve Motor Function and Cell Loss after Focal Brain Ischemia in Mice. ( 27488634 )
2016
35
The phosphodiesterase type 2 inhibitor BAY 60-7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity. ( 27813297 )
2016
36
OS 18-02 ANTIHYPERTENSIVE TREATMENT AND RISK OF BRAIN ISCHEMIA DUE TO CAROTID STENOSIS IN A SURVEY OF HOSPITALISED PATIENTS AGED 90 YEARS AND OLDER. ( 27642991 )
2016
37
SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion. ( 27882949 )
2016
38
OS 18-02 ANTIHYPERTENSIVE TREATMENT AND RISK OF BRAIN ISCHEMIA DUE TO CAROTID STENOSIS IN A SURVEY OF HOSPITALISED PATIENTS AGED 90 YEARS AND OLDER. ( 27754070 )
2016
39
Downregulation of GABAA Receptor Recycling Mediated by HAP1 Contributes to Neuronal Death in In Vitro Brain Ischemia. ( 26732589 )
2016
40
Lectin Complement Pathway and Its Bloody Interactions in Brain Ischemia. ( 27811336 )
2016
41
N-Acetylcysteine and Ceftriaxone as Preconditioning Strategies in Focal Brain Ischemia: Influence on Glutamate Transporters Expression. ( 26861954 )
2016
42
The antioxidative property of melatonin against brain ischemia. ( 27108742 )
2016
43
Polarizing the immune system towards neuroprotection in brain ischemia. ( 26981089 )
2016
44
Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway. ( 27596278 )
2016
45
Partial loss of VE-cadherin improves long-term outcome and cerebral blood flow after transient brain ischemia in mice. ( 27538712 )
2016
46
A Novel GSK-3I^ inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway. ( 27108601 )
2016
47
Hyperbaric oxygen increases tissue-plasminogen activator-induced thrombolysis in vitro, and reduces ischemic brain damage and edema in rats subjected to thromboembolic brain ischemia. ( 27867469 )
2016
48
Induction of Perivascular Neural Stem Cells and Possible Contribution to Neurogenesis Following Transient Brain Ischemia/Reperfusion Injury. ( 27352866 )
2016
49
The Role of I_ Opioid Receptor in Brain Ischemia. ( 27495821 )
2016
50
Alzheimer-associated presenilin 2 gene is dysregulated in rat medial temporal lobe cortex after complete brain ischemia due to cardiac arrest. ( 26721367 )
2016

Variations for Brain Ischemia

Expression for Brain Ischemia

Search GEO for disease gene expression data for Brain Ischemia.

Pathways for Brain Ischemia

Pathways related to Brain Ischemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.82 EDN1 MAP2
2 10.72 EDN1 NOS2
3 10.7 GFAP MAP2 NES
4 10.49 ADCY10 EDN1

GO Terms for Brain Ischemia

Cellular components related to Brain Ischemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 9.26 GFAP NES
2 dendrite GO:0030425 9.26 ADCY10 ADORA1 KCNB1 MAP2
3 basal part of cell GO:0045178 9.16 ADCY10 EDN1
4 cell body GO:0044297 8.32 ADORA1

Biological processes related to Brain Ischemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.43 ADORA1 EDN1 NOS2
2 negative regulation of blood pressure GO:0045776 9.37 ADORA1 NOS2
3 regulation of sensory perception of pain GO:0051930 9.32 ADORA1 EDN1
4 positive regulation of cardiac muscle hypertrophy GO:0010613 9.16 EDN1 PARP1
5 regulation of protein complex assembly GO:0043254 8.96 GFAP HSPA8
6 negative regulation of hormone secretion GO:0046888 8.62 ADORA1 EDN1

Molecular functions related to Brain Ischemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.62 MAP2 NES

Sources for Brain Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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