MCID: BRN035
MIFTS: 39

Brain Stem Glioma malady

Neuronal diseases, Cancer diseases categories
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Summaries for Brain Stem Glioma

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65Wikipedia, 33MalaCards
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Wikipedia:65 A brainstem glioma is a cancerous glioma tumor in the brainstem. more...

MalaCards: Brain Stem Glioma, also known as brainstem neuroglial tumor, is related to childhood brain stem glioma and adult brain stem glioma. An important gene associated with Brain Stem Glioma is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are AHR Pathway and Gefitinib Pathway, Pharmacokinetics. The compounds scopoletin and chrysin have been mentioned in the context of this disorder. Affiliated tissues include brain.

Aliases & Classifications for Brain Stem Glioma

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8Disease Ontology, 10DISEASES, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain stem glioma 8 10
brainstem neuroglial tumor 8
glioma of brainstem 62


External Ids:

Disease Ontology8 DOID:4202
NCIt40 C8501

Related Diseases for Brain Stem Glioma

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17GeneCards, 18GeneDecks
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Diseases in the Brain Stem Glioma family:

Adult Brain Stem Glioma

Diseases related to Brain Stem Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1childhood brain stem glioma10.5
2adult brain stem glioma10.4
3meningoencephalitis10.2
4moyamoya disease10.2
5encephalitis10.2
6hydrocephalus10.2
7panniculitis10.2
8dysphagia10.2
9myokymia10.2
10gilbert syndrome10.1UGT1A1
11crigler najjar syndrome, type 210.1UGT1A, UGT1A1
12crigler-najjar syndrome10.1UGT1A, UGT1A1
13bilirubin metabolic disorder10.1UGT1A, UGT1A1
14factor vii deficiency10.0EGFR, UGT1A1
15diarrhea10.0EGFR, UGT1A1
16neutropenia10.0UGT1A1, EGFR
17endometrial carcinoma10.0EGFR, UGT1A1, UGT1A
18anaplastic astrocytoma10.0EGFR, BSG
19laryngeal benign neoplasm10.0EGFR, BIRC5
20bladder carcinoma in situ10.0EGFR, BIRC5
21pancreatic cancer10.0EGFR, BIRC5
22oral cancer10.0BIRC5, EGFR
23laryngeal squamous cell carcinoma9.9BSG, BIRC5, EGFR
24transitional cell carcinoma9.9EGFR, BIRC5, BSG
25colorectal cancer9.9BIRC5, EPHA2, EGFR
26cervical cancer9.9BSG, BIRC5, EGFR
27malignant glioma9.9EGFR, BIRC5, BSG
28stomach cancer9.9BIRC5, BSG, EGFR
29glioblastoma multiforme9.9EPHA2, BIRC5, EGFR
30lung cancer9.9EGFR, BIRC5, BSG
31ipex syndrome9.9UGT1A, UGT1A1, BSG
32colon cancer9.9UGT1A, EPHA2, BIRC5, EGFR
33hepatocellular carcinoma9.9UGT1A, BIRC5, BSG, UGT1A1
34non-small cell lung carcinoma9.9EGFR, UGT1A1, EPHA2, BIRC5
35breast cancer9.9EGFR, BIRC5, BSG
36bladder carcinoma9.9UGT1A, BSG, BIRC5, EGFR
37prostate cancer9.9EGFR, EPHA2, UGT1A, BIRC5
38kidney cancer9.9BIRC5, EGFR, EPHA2, BSG
39ovarian cancer9.9BIRC5, EGFR, EPHA2, BSG
40tongue squamous cell carcinoma9.9EGFR, BIRC5, BSG, EPHA2
41adenocarcinoma9.9EPHA2, BSG, EGFR, UGT1A1, BIRC5

Graphical network of the top 20 diseases related to Brain Stem Glioma:



Diseases related to brain stem glioma

Symptoms for Brain Stem Glioma

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Drugs & Therapeutics for Brain Stem Glioma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Brain Stem Glioma

Search NIH Clinical Center for Brain Stem Glioma

Genetic Tests for Brain Stem Glioma

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Anatomical Context for Brain Stem Glioma

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33MalaCards
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MalaCards organs/tissues related to Brain Stem Glioma:

33
Brain

Animal Models for Brain Stem Glioma or affiliated genes

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Publications for Brain Stem Glioma

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52PubMed
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Articles related to Brain Stem Glioma:

(show all 50)
idTitleAuthorsYear
1
Intracranial syphilitic gumma mimicking a brain stem glioma. (22723064)
2012
2
Treatment of progressive brain stem glioma with bevacizumab: radiological, metabolic and histopathological aspects. (22048887)
2012
3
Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. (21233173)
2011
4
Shall we treat hydrocephalus associated to brain stem glioma in children? (21928037)
2011
5
DTI fiber tracking to differentiate demyelinating diseases from diffuse brain stem glioma. (20363335)
2010
6
Diffuse brain stem glioma. (20212241)
2010
7
Brain stem glioma, a rare cause of hearing loss and dysequilibrium. (21063295)
2008
8
Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas. (18324354)
2008
9
Commentary on diffuse brain stem glioma in children. (19016114)
2008
10
Treatment of children with diffuse intrinsic brain stem glioma with radiotherapy, vincristine and oral VP-16: a Children's Oncology Group phase II study. (17278121)
2008
11
Somatostatin-receptor positive brain stem glioma visualized by octreoscan. (17627256)
2007
12
HSV encephalitis in a child with brain stem glioma: a rare complication of therapy. Case report and review of the neurosurgical literature. (17593375)
2007
13
Irinotecan therapy in a 12-year-old girl with recurrent brain stem glioma and without functional polymorphisms in UGT1A1 activity: case report. (16187025)
2005
14
Biopsy of brain stem glioma using motor-evoked potential mapping by direct peduncular stimulation and individual adjuvant therapy. Case report. (15699622)
2005
15
Brain stem glioma: two case studies. (15695354)
2005
16
ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma. (14506149)
2003
17
Brain stem glioma in a child: false diagnosis of radiation necrosis with FDG PET. (12555260)
2003
18
Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic brain stem glioma: a preliminary report. (12718563)
2003
19
Recurrent haemorrhage from a malignant brain stem glioma: a review of the mechanisms of tumoural haemorrhage. (12948477)
2003
20
Moyamoya disease associated with a brain stem glioma. (10855525)
2000
21
Brain stem glioma--a study of 111 patients. (10921213)
1999
22
Clinical management of brain stem glioma. (10332008)
1999
23
Diffuse brain stem glioma. A review of stereotactic biopsies. (10392494)
1999
24
Neuroimaging of pediatric brain stem diseases other than brain stem glioma. (9075252)
1996
25
Leptomyxid amebic meningoencephalitis mimicking brain stem glioma. (7611076)
1995
26
Bilateral jawline nodules in a child with a brain-stem glioma. Poststeroid panniculitis. (7492138)
1995
27
Quality of survival among children treated for brain stem glioma. (8043460)
1994
28
Intra-arterial chemotherapy for brain stem glioma: report of four cases. (8108006)
1994
29
Brain-stem glioma growth patterns. (8433142)
1993
30
Radiotherapy for pediatric brain stem glioma: radiation dose, response, and survival. (1407449)
1992
31
Pathological laughter and brain stem glioma. (1640246)
1992
32
Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma. (1902547)
1991
33
Brain stem glioma: the role of a biopsy. (1892569)
1991
34
Prolonged response to carboplatin in an infant with brain stem glioma. (1985722)
1991
35
A case of dyschondroplasia associated with brain stem glioma: diagnosis by stereotactic biopsy. (2234348)
1990
36
Nursing care of the child with a brain stem glioma. (2254841)
1990
37
Chronic dysphagia, vomiting and gastroesophageal reflux as manifestations of a brain stem glioma: a case report. (2488955)
1989
38
Hyperfractionated radiation therapy for brain-stem glioma: a phase I-II trial. (2709109)
1989
39
Transient late magnetic resonance imaging changes suggesting progression of brain stem glioma: implications for entry criteria for phase II trials. (3054620)
1988
40
Brain stem glioma mimicking progressive basilar artery thrombosis. (2834522)
1988
41
Brain stem glioma presenting as gastro-oesophageal reflux. (3632023)
1987
42
Orthostatic hypotension with lower brain stem glioma. (7161610)
1982
43
Brain stem glioma in childhood: acute hemiplegic onset. (6269714)
1981
44
Brain stem glioma complicated by Strongyloides stercoralis. (7325594)
1981
45
Hysterical symptoms masking brain stem glioma. (204623)
1978
46
Myokymia and facial contraction in brain stem glioma. An electromyographic study. (4827058)
1974
47
An unusual case of brain stem glioma with prolonged spontaneous remission and downbeat nystagmus. (4745685)
1973
48
Brain stem glioma causing failure to thrive. (5542786)
1971
49
Clinicopathologic conference. Baptist Memorial Hospital. Brain stem glioma in children. (4313782)
1970
50
Paroxysmal skew deviation in association with a brain stem glioma. Report of an unusual case. (13860590)
1962

Variations for Brain Stem Glioma

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Expression for genes affiliated with Brain Stem Glioma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Stem Glioma

Search GEO for disease gene expression data for Brain Stem Glioma.

Pathways for genes affiliated with Brain Stem Glioma

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50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 51PharmGKB, 60Thomson Reuters, 12EMD Millipore, 30KEGG
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Compounds for genes affiliated with Brain Stem Glioma

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Brain Stem Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1scopoletin459.7UGT1A, UGT1A1
2chrysin459.7UGT1A, UGT1A1
3morphine 6-glucuronide459.7UGT1A1, UGT1A
4morphine-3-glucuronide459.7UGT1A1, UGT1A
5sn38 glucuronide459.7UGT1A1, UGT1A
64-methylumbelliferone459.7UGT1A1, UGT1A
71-naphthol459.7UGT1A, UGT1A1
8n-hydroxy phip459.6UGT1A, UGT1A1
9atazanavir45 51 1111.6UGT1A1, UGT1A
10su5416459.6EGFR, BIRC5
11udp glucuronic acid459.6UGT1A, UGT1A1
12lamotrigine45 51 1111.6UGT1A, UGT1A1
13bexarotene45 29 1111.6BIRC5, EGFR
14mithramycin459.6EGFR, BIRC5
15glucuronide459.5UGT1A, UGT1A1
16benzidine459.5UGT1A, UGT1A1
17regorafenib51 1110.5UGT1A1, EGFR, EPHA2
18flunitrazepam29 45 1111.5UGT1A, UGT1A1
19luteolin459.5BIRC5, UGT1A
20pd153035459.4EGFR, BIRC5
21erlotinib45 51 1111.4EGFR, UGT1A1, BIRC5
22silymarin459.4BIRC5, EGFR, UGT1A1
23oxaliplatin45 51 1111.4UGT1A1, EGFR, BIRC5
24flavopiridol45 1110.4EGFR, UGT1A1, BIRC5
25thymidylate459.4BIRC5, EGFR, UGT1A1
26naproxen45 24 1111.3UGT1A1, UGT1A
27apigenin45 2910.3UGT1A1, UGT1A
28flurbiprofen45 29 51 1112.3UGT1A1, UGT1A
29lapatinib45 51 1111.2EGFR, BIRC5
30mycophenolic acid45 51 1111.2BIRC5, UGT1A1, UGT1A
315fluorouracil459.1BIRC5, UGT1A1, EGFR
32troglitazone45 29 61 1112.1BIRC5, UGT1A1, UGT1A
33quercetin45 61 24 1112.1UGT1A1, BIRC5, UGT1A
34sn 3845 6110.1EGFR, UGT1A, UGT1A1
35agar459.1EGFR, BIRC5, EPHA2
36irinotecan45 51 1111.1UGT1A, UGT1A1, EGFR
37nicotine45 29 51 1112.1UGT1A, UGT1A1, BIRC5
38resveratrol45 61 24 1112.1UGT1A, BIRC5, BSG
39phosphoinositide458.9BIRC5, EPHA2, BSG, EGFR
40progesterone45 29 61 24 1112.9EGFR, UGT1A1, BSG, BIRC5
41daidzein458.8UGT1A, BIRC5
42vegf458.7BIRC5, EPHA2, BSG, EGFR
43egcg458.6BIRC5, UGT1A, EGFR, UGT1A1
44curcumin458.6BIRC5, UGT1A1, UGT1A, EGFR
45tamoxifen45 51 29 1111.6UGT1A1, EGFR, UGT1A, BIRC5
46genistein45 29 61 3 24 1113.6EGFR, UGT1A1, BIRC5, UGT1A
47testosterone45 61 24 1111.5EGFR, BIRC5, UGT1A, UGT1A1
48tyrosine458.4UGT1A1, BSG, EPHA2, EGFR, BIRC5
49serine457.9UGT1A, BSG, EGFR, BIRC5, TMPRSS11D
50estrogen457.7EPHA2, UGT1A, UGT1A1, BSG, EGFR, BIRC5

GO Terms for genes affiliated with Brain Stem Glioma

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16Gene Ontology
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Cellular components related to Brain Stem Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7EPHA2, TMPRSS11D, BSG, UGT1A1

Biological processes related to Brain Stem Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine phosphorylationGO:0181089.4EGFR, EPHA2
2liver developmentGO:0018899.2EGFR, UGT1A1

Molecular functions related to Brain Stem Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.1EGFR, EPHA2
2protein heterodimerization activityGO:0469829.0EGFR, BIRC5, UGT1A1
3enzyme bindingGO:0198998.9EGFR, BIRC5, UGT1A1

Products for genes affiliated with Brain Stem Glioma

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  • Antibodies
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Sources for Brain Stem Glioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet