MCID: BRN035
MIFTS: 34

Brain Stem Glioma malady

Neuronal, Cancer categories

Summaries for Brain Stem Glioma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A brainstem glioma is a cancerous glioma tumor in the brainstem. more...

MalaCards: Brain Stem Glioma, also known as brainstem neuroglial tumor, is related to brain glioma and adult brain stem glioma. An important gene associated with Brain Stem Glioma is EPHA2 (EPH receptor A2), and among its related pathways are Stabilization and expansion of the E-cadherin adherens junction and Arf6 signaling events. The compounds resveratrol and Regorafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and pons.

Aliases & Classifications for Brain Stem Glioma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

brain stem glioma 8 10
brainstem neuroglial tumor 8
glioma of brainstem 61


External Ids:

Disease Ontology8 DOID:4202
NCIt40 C8501

Related Diseases for Brain Stem Glioma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Brain Stem Glioma family:

adult brain stem glioma

Diseases related to Brain Stem Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1brain glioma11.0
2adult brain stem glioma10.4
3brain disease10.4
4moyamoya disease10.2
5meningoencephalitis10.2
6dysphagia10.2
7myokymia10.2
8hepatitis10.0UGT1A1
9sarcoma10.0EPHA2
10adenoma10.0BIRC5
11familial adenomatous polyposis10.0BIRC5
12crigler najjar syndrome, type 210.0UGT1A, UGT1A1
13crigler-najjar syndrome10.0UGT1A1, UGT1A
14bilirubin metabolic disorder10.0UGT1A1, UGT1A
15gilbert syndrome10.0UGT1A1
16ependymoma10.0EGFR
17bladder carcinoma10.0BSG
18neutropenia10.0EGFR, UGT1A1
19factor vii deficiency10.0UGT1A1, EGFR
20diarrhea10.0UGT1A1, EGFR
21laryngeal carcinoma10.0BIRC5, EGFR
22endometrial carcinoma10.0UGT1A, EGFR, UGT1A1
23astrocytoma10.0BSG, EGFR
24bladder carcinoma in situ10.0EGFR, BIRC5
25squamous cell carcinoma of the head and neck10.0BIRC5, EGFR, FANCL
26hepatocellular carcinoma10.0BSG, UGT1A, UGT1A1, BIRC5
27laryngeal squamous cell carcinoma10.0BIRC5, EGFR, BSG
28pancreatic cancer10.0BIRC5, BSG, EGFR
29transitional cell carcinoma10.0EGFR, BIRC5, BSG
30non-small cell lung carcinoma10.0BIRC5, UGT1A1, EPHA2, EGFR
31cervical cancer10.0BIRC5, EGFR, BSG
32colon cancer10.0BIRC5, UGT1A, EGFR, EPHA2
33stomach cancer10.0BIRC5, BSG, EGFR
34glioblastoma multiforme10.0BIRC5, EPHA2, EGFR, BSG
35kidney cancer10.0BSG, BIRC5, EPHA2, EGFR
36ovarian cancer10.0EGFR, BIRC5, EPHA2, BSG
37prostate cancer10.0BIRC5, EPHA2, EGFR
38lung cancer10.0BSG, EGFR, BIRC5
39malignant glioma10.0BSG, EGFR, EPHA2, BIRC5
40squamous cell carcinoma10.0BIRC5, EPHA2, EGFR, BSG
41adenocarcinoma10.0BSG, BIRC5, EGFR, EPHA2, UGT1A1
42colorectal cancer10.0BIRC5, UGT1A1, EGFR, EPHA2, UGT1A, BSG
43breast cancer9.9EGFR, UGT1A1, FANCL, BSG, UGT1A, BIRC5

Graphical network of the top 20 diseases related to Brain Stem Glioma:



Diseases related to brain stem glioma

Clinical Features for Brain Stem Glioma

Drugs & Therapeutics for Brain Stem Glioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Brain Stem Glioma

Drug clinical trials:

Search ClinicalTrials for Brain Stem Glioma

Search NIH Clinical Center for Brain Stem Glioma

Search CenterWatch for Brain Stem Glioma

Genetic Tests for Brain Stem Glioma

Anatomical Context for Brain Stem Glioma

Sources:
33MalaCards
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MalaCards organs/tissues related to Brain Stem Glioma:

33
Brain, Endothelial, Pons

Animal Models for Brain Stem Glioma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Brain Stem Glioma

Sources:
51PubMed
See all sources

Articles related to Brain Stem Glioma:

(show top 50)    (show all 65)
idTitleAuthorsYear
1
Human brain glioma stem cells are more invasive than their differentiated progeny cells in vitro. (22153826)
2012
2
A simplified and modified procedure to culture brain glioma stem cells from clinical specimens. (22740855)
2012
3
Treatment of progressive brain stem glioma with bevacizumab: radiological, metabolic and histopathological aspects. (22048887)
2012
4
Expression levels of Fas/Fas-L mRNA in human brain glioma stem cells. (22344564)
2012
5
Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma. (20663133)
2010
6
microRNA-34a is tumor suppressive in brain tumors and glioma stem cells. (20190569)
2010
7
DTI fiber tracking to differentiate demyelinating diseases from diffuse brain stem glioma. (20363335)
2010
8
Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype. (21321379)
2010
9
Dual-targeted antitumor effects against brainstem glioma by intravenous delivery of tumor necrosis factor-related, apoptosis-inducing, ligand-engineered human mesenchymal stem cells. (19687708)
2009
10
Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells. (19638465)
2009
11
Commentary on diffuse brain stem glioma in children. (19016114)
2008
12
Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma. (18230189)
2008
13
Treatment of children with diffuse intrinsic brain stem glioma with radiotherapy, vincristine and oral VP-16: a Children's Oncology Group phase II study. (17278121)
2008
14
Somatostatin-receptor positive brain stem glioma visualized by octreoscan. (17627256)
2007
15
HSV encephalitis in a child with brain stem glioma: a rare complication of therapy. Case report and review of the neurosurgical literature. (17593375)
2007
16
Chemoresistance of CD133(+) tumor stem cells from human brain glioma]. (17767043)
2007
17
Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma. (17999604)
2007
18
Isolation and culture of tumor stem cells from human brain glioma tissues]. (17044993)
2006
19
Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. (16616334)
2006
20
Irinotecan therapy in a 12-year-old girl with recurrent brain stem glioma and without functional polymorphisms in UGT1A1 activity: case report. (16187025)
2005
21
Biopsy of brain stem glioma using motor-evoked potential mapping by direct peduncular stimulation and individual adjuvant therapy. Case report. (15699622)
2005
22
Brain stem glioma: two case studies. (15695354)
2005
23
ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma. (14506149)
2003
24
Brain stem glioma in a child: false diagnosis of radiation necrosis with FDG PET. (12555260)
2003
25
Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic brain stem glioma: a preliminary report. (12718563)
2003
26
Moyamoya disease associated with a brain stem glioma. (10855525)
2000
27
Brain stem glioma--a study of 111 patients. (10921213)
1999
28
Diffuse brain stem glioma. A review of stereotactic biopsies. (10392494)
1999
29
Neuroimaging of pediatric brain stem diseases other than brain stem glioma. (9075252)
1996
30
Leptomyxid amebic meningoencephalitis mimicking brain stem glioma. (7611076)
1995
31
Quality of survival among children treated for brain stem glioma. (8043460)
1994
32
Intra-arterial chemotherapy for brain stem glioma: report of four cases. (8108006)
1994
33
Brain-stem glioma growth patterns. (8433142)
1993
34
Radiotherapy for pediatric brain stem glioma: radiation dose, response, and survival. (1407449)
1992
35
Pathological laughter and brain stem glioma. (1640246)
1992
36
Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma. (1902547)
1991
37
Prolonged response to carboplatin in an infant with brain stem glioma. (1985722)
1991
38
Nursing care of the child with a brain stem glioma. (2254841)
1990
39
Chronic dysphagia, vomiting and gastroesophageal reflux as manifestations of a brain stem glioma: a case report. (2488955)
1989
40
Hyperfractionated radiation therapy for brain-stem glioma: a phase I-II trial. (2709109)
1989
41
Transient late magnetic resonance imaging changes suggesting progression of brain stem glioma: implications for entry criteria for phase II trials. (3054620)
1988
42
Brain stem glioma mimicking progressive basilar artery thrombosis. (2834522)
1988
43
Brain stem glioma presenting as gastro-oesophageal reflux. (3632023)
1987
44
Orthostatic hypotension with lower brain stem glioma. (7161610)
1982
45
Brain stem glioma in childhood: acute hemiplegic onset. (6269714)
1981
46
Myokymia and facial contraction in brain stem glioma. An electromyographic study. (4827058)
1974
47
An unusual case of brain stem glioma with prolonged spontaneous remission and downbeat nystagmus. (4745685)
1973
48
Brain stem glioma causing failure to thrive. (5542786)
1971
49
Clinicopathologic conference. Baptist Memorial Hospital. Brain stem glioma in children. (4313782)
1970
50
Gliomas of the brain stem. I. Study of a gangliocytoma of the pons penetrating into the hypothalamic region]. (13079693)
1953

Genetic Variations for Brain Stem Glioma

Expression for genes affiliated with Brain Stem Glioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Brain Stem Glioma

Search GEO for disease gene expression data for Brain Stem Glioma.

Pathways for genes affiliated with Brain Stem Glioma

Sources:
38NCBI BioSystems Database, 50PharmGKB
See all sources

Pathways related to Brain Stem Glioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7EPHA2, EGFR
29.7EPHA2, EGFR
39.6EGFR, UGT1A1
4
Hide members
9.6EGFR, UGT1A1

Compounds for genes affiliated with Brain Stem Glioma

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Brain Stem Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1resveratrol45 60 11 2413.2UGT1A
2Regorafenib1110.0UGT1A1, EPHA2
3scopoletin4510.0UGT1A1, UGT1A
4morphine 6-glucuronide4510.0UGT1A, UGT1A1
5chrysin4510.0UGT1A, UGT1A1
6morphine-3-glucuronide4510.0UGT1A, UGT1A1
7sn38 glucuronide4510.0UGT1A, UGT1A1
81-naphthol459.9UGT1A1, UGT1A
94-methylumbelliferone459.9UGT1A1, UGT1A
10n-hydroxy phip459.9UGT1A, UGT1A1
11atazanavir45 50 1111.9UGT1A, UGT1A1
12udp glucuronic acid459.9UGT1A1, UGT1A
13su5416459.9BIRC5, EGFR
14lamotrigine45 1110.9UGT1A1, UGT1A
15glucuronide459.9UGT1A, UGT1A1
16bexarotene45 29 1111.9EGFR, BIRC5
17benzidine459.9UGT1A, UGT1A1
18mithramycin459.9EGFR, BIRC5
19flunitrazepam45 29 1111.9UGT1A, UGT1A1
20pd153035459.8BIRC5, EGFR
21naproxen45 11 2411.8UGT1A1, UGT1A
22luteolin459.8BIRC5, UGT1A
23apigenin45 2910.8UGT1A1, UGT1A
24lapatinib45 50 1111.8BIRC5, EGFR
25phip459.7UGT1A1, UGT1A
26flurbiprofen45 29 50 1112.7UGT1A1, UGT1A
27erlotinib45 50 1111.7BIRC5, EGFR, UGT1A1
28daidzein459.7UGT1A, BIRC5
29silymarin459.7UGT1A1, EGFR, BIRC5
30oxaliplatin45 50 1111.7BIRC5, EGFR, UGT1A1
31flavopiridol45 1110.7UGT1A1, EGFR, BIRC5
32dasatinib45 50 1111.7EPHA2, EGFR
33buprenorphine45 29 1111.6UGT1A, UGT1A1
34thymidylate459.6BIRC5, EGFR, UGT1A1
35cotinine45 2410.6UGT1A, UGT1A1
36mycophenolic acid45 50 1111.6BIRC5, UGT1A1, UGT1A
37troglitazone45 29 60 1112.5UGT1A, UGT1A1, BIRC5
38quercetin45 60 11 2412.5BIRC5, UGT1A1, UGT1A
39sn 3845 6010.5EGFR, UGT1A1, UGT1A
40epothilone b60 45 1111.4BIRC5, EGFR
41irinotecan45 50 1111.4EGFR, UGT1A1, UGT1A
42nicotine45 50 29 1112.4UGT1A, UGT1A1, BIRC5
43flavonoid459.2UGT1A1, UGT1A
44phosphoinositide459.2BSG, EGFR, EPHA2, BIRC5
45curcumin459.0UGT1A, UGT1A1, EGFR, BIRC5
46tamoxifen45 50 29 1112.0BIRC5, EGFR, UGT1A1, UGT1A
47progesterone45 60 29 11 2413.0BSG, UGT1A1, EGFR, BIRC5
48genistein45 29 60 2 11 2414.0BIRC5, EGFR, UGT1A1, UGT1A
49testosterone45 60 11 2411.6UGT1A, UGT1A1, EGFR, BIRC5
50tyrosine458.3BSG, UGT1A1, EGFR, EPHA2, BIRC5, PTPRN2

GO Terms for genes affiliated with Brain Stem Glioma

Sources:
16Gene Ontology
See all sources

Molecular functions related to Brain Stem Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.4EPHA2, EGFR
2enzyme bindingGO:0198999.2BIRC5, EGFR, UGT1A1

Products for genes affiliated with Brain Stem Glioma

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Sources for Brain Stem Glioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet