MCID: BRN035
MIFTS: 41

Brain Stem Glioma malady

Cancer diseases, Neuronal diseases categories

Summaries for Brain Stem Glioma

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Wikipedia:64 A brainstem glioma is a cancerous glioma tumor in the brainstem. more...

MalaCards based summary: Brain Stem Glioma, also known as brain stem neuroglial tumor, is related to childhood brain stem glioma and gilbert syndrome. An important gene associated with Brain Stem Glioma is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are AHR Pathway and Gefitinib Pathway, Pharmacokinetics. The compounds scopoletin and chrysin have been mentioned in the context of this disorder. Affiliated tissues include brain and spinal cord.

Aliases & Classifications for Brain Stem Glioma

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Brain Stem Glioma, Aliases & Descriptions:

Name: Brain Stem Glioma 9 11
Brain Stem Neuroglial Tumor 61
 
Brainstem Neuroglial Tumor 9
Glioma of Brainstem 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:4202
NCIt39 C8501

Related Diseases for Brain Stem Glioma

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Diseases in the Brain Stem Glioma family:

Adult Brain Stem Glioma

Diseases related to Brain Stem Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1childhood brain stem glioma10.5
2gilbert syndrome10.4UGT1A1
3adult brain stem glioma10.4
4crigler najjar syndrome, type 210.3UGT1A, UGT1A1
5crigler-najjar syndrome10.3UGT1A1, UGT1A
6bilirubin metabolic disorder10.3UGT1A, UGT1A1
7hydrocephalus10.2
8moyamoya disease10.2
9neurofibromatosis10.2
10meningoencephalitis10.2
11demyelinating disease10.2
12encephalitis10.2
13panniculitis10.2
14dysphagia10.2
15myokymia10.2
16factor vii deficiency10.2UGT1A1, EGFR
17diarrhea10.1EGFR, UGT1A1
18neutropenia10.1UGT1A1, EGFR
19grade iii astrocytoma10.1EGFR, BSG
20endometrial carcinoma10.1EGFR, UGT1A1, UGT1A
21laryngeal benign neoplasm10.0EGFR, BIRC5
22bladder carcinoma in situ10.0EGFR, BIRC5
23oral cancer9.9BIRC5, EGFR
24squamous cell carcinoma of the head and neck9.9EGFR, BIRC5
25ipex syndrome9.8BSG, UGT1A1, UGT1A
26laryngeal squamous cell carcinoma9.8EGFR, BIRC5, BSG
27transitional cell carcinoma9.8EGFR, BIRC5, BSG
28colorectal cancer9.8EGFR, BIRC5, EPHA2
29cervical cancer9.8BSG, BIRC5, EGFR
30malignant glioma9.8EGFR, BIRC5, BSG
31pancreatic cancer9.8EGFR, BIRC5
32glioblastoma9.8EPHA2, BIRC5, EGFR
33stomach cancer9.8EGFR, BIRC5, BSG
34lung cancer9.7BSG, BIRC5, EGFR
35colonic benign neoplasm9.7UGT1A, EPHA2, BIRC5, EGFR
36breast cancer9.7EGFR, BIRC5, BSG
37liver cancer9.7UGT1A, UGT1A1, BSG, BIRC5
38non-small cell lung carcinoma9.6UGT1A1, EPHA2, BIRC5, EGFR
39bladder carcinoma9.6EGFR, BIRC5, BSG, UGT1A
40prostate cancer9.6UGT1A, EPHA2, BIRC5, EGFR
41glioblastoma multiforme9.6BSG, EPHA2, BIRC5, EGFR
42kidney cancer9.6BSG, EPHA2, BIRC5, EGFR
43ovarian cancer9.5BSG, EPHA2, BIRC5, EGFR
44tongue squamous cell carcinoma9.5EGFR, BIRC5, EPHA2, BSG
45adenocarcinoma9.4UGT1A1, BSG, EPHA2, BIRC5, EGFR

Graphical network of the top 20 diseases related to Brain Stem Glioma:



Diseases related to brain stem glioma

Symptoms for Brain Stem Glioma

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Drugs & Therapeutics for Brain Stem Glioma

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Drug clinical trials:

Search ClinicalTrials for Brain Stem Glioma

Search NIH Clinical Center for Brain Stem Glioma

Genetic Tests for Brain Stem Glioma

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Anatomical Context for Brain Stem Glioma

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MalaCards organs/tissues related to Brain Stem Glioma:

32
Brain, Spinal cord

Animal Models for Brain Stem Glioma or affiliated genes

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Publications for Brain Stem Glioma

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Articles related to Brain Stem Glioma:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
Brain stem glioma with spinal cord involvement in a young with neurofibromatosis type 1. (24614250)
2014
2
Intracranial syphilitic gumma mimicking a brain stem glioma. (22723064)
2012
3
Treatment of progressive brain stem glioma with bevacizumab: radiological, metabolic and histopathological aspects. (22048887)
2012
4
Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. (21233173)
2011
5
Shall we treat hydrocephalus associated to brain stem glioma in children? (21928037)
2011
6
DTI fiber tracking to differentiate demyelinating diseases from diffuse brain stem glioma. (20363335)
2010
7
Diffuse brain stem glioma. (20212241)
2010
8
Brain stem glioma, a rare cause of hearing loss and dysequilibrium. (21063295)
2008
9
Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas. (18324354)
2008
10
Commentary on diffuse brain stem glioma in children. (19016114)
2008
11
Treatment of children with diffuse intrinsic brain stem glioma with radiotherapy, vincristine and oral VP-16: a Children's Oncology Group phase II study. (17278121)
2008
12
Somatostatin-receptor positive brain stem glioma visualized by octreoscan. (17627256)
2007
13
HSV encephalitis in a child with brain stem glioma: a rare complication of therapy. Case report and review of the neurosurgical literature. (17593375)
2007
14
Irinotecan therapy in a 12-year-old girl with recurrent brain stem glioma and without functional polymorphisms in UGT1A1 activity: case report. (16187025)
2005
15
Biopsy of brain stem glioma using motor-evoked potential mapping by direct peduncular stimulation and individual adjuvant therapy. Case report. (15699622)
2005
16
Brain stem glioma: two case studies. (15695354)
2005
17
ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma. (14506149)
2003
18
Brain stem glioma in a child: false diagnosis of radiation necrosis with FDG PET. (12555260)
2003
19
Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic brain stem glioma: a preliminary report. (12718563)
2003
20
Recurrent haemorrhage from a malignant brain stem glioma: a review of the mechanisms of tumoural haemorrhage. (12948477)
2003
21
Moyamoya disease associated with a brain stem glioma. (10855525)
2000
22
Brain stem glioma--a study of 111 patients. (10921213)
1999
23
Clinical management of brain stem glioma. (10332008)
1999
24
Diffuse brain stem glioma. A review of stereotactic biopsies. (10392494)
1999
25
Neuroimaging of pediatric brain stem diseases other than brain stem glioma. (9075252)
1996
26
Leptomyxid amebic meningoencephalitis mimicking brain stem glioma. (7611076)
1995
27
Bilateral jawline nodules in a child with a brain-stem glioma. Poststeroid panniculitis. (7492138)
1995
28
Quality of survival among children treated for brain stem glioma. (8043460)
1994
29
Intra-arterial chemotherapy for brain stem glioma: report of four cases. (8108006)
1994
30
Brain-stem glioma growth patterns. (8433142)
1993
31
Radiotherapy for pediatric brain stem glioma: radiation dose, response, and survival. (1407449)
1992
32
Pathological laughter and brain stem glioma. (1640246)
1992
33
Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma. (1902547)
1991
34
Brain stem glioma: the role of a biopsy. (1892569)
1991
35
Prolonged response to carboplatin in an infant with brain stem glioma. (1985722)
1991
36
A case of dyschondroplasia associated with brain stem glioma: diagnosis by stereotactic biopsy. (2234348)
1990
37
Nursing care of the child with a brain stem glioma. (2254841)
1990
38
Chronic dysphagia, vomiting and gastroesophageal reflux as manifestations of a brain stem glioma: a case report. (2488955)
1989
39
Hyperfractionated radiation therapy for brain-stem glioma: a phase I-II trial. (2709109)
1989
40
Transient late magnetic resonance imaging changes suggesting progression of brain stem glioma: implications for entry criteria for phase II trials. (3054620)
1988
41
Brain stem glioma mimicking progressive basilar artery thrombosis. (2834522)
1988
42
Brain stem glioma presenting as gastro-oesophageal reflux. (3632023)
1987
43
Orthostatic hypotension with lower brain stem glioma. (7161610)
1982
44
Brain stem glioma in childhood: acute hemiplegic onset. (6269714)
1981
45
Brain stem glioma complicated by Strongyloides stercoralis. (7325594)
1981
46
Myokymia and facial contraction in brain stem glioma. An electromyographic study. (4827058)
1974
47
An unusual case of brain stem glioma with prolonged spontaneous remission and downbeat nystagmus. (4745685)
1973
48
Brain stem glioma causing failure to thrive. (5542786)
1971
49
Clinicopathologic conference. Baptist Memorial Hospital. Brain stem glioma in children. (4313782)
1970
50
Paroxysmal skew deviation in association with a brain stem glioma. Report of an unusual case. (13860590)
1962

Variations for Brain Stem Glioma

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Expression for genes affiliated with Brain Stem Glioma

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Expression patterns in normal tissues for genes affiliated with Brain Stem Glioma

Search GEO for disease gene expression data for Brain Stem Glioma.

Pathways for genes affiliated with Brain Stem Glioma

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Compounds for genes affiliated with Brain Stem Glioma

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Compounds related to Brain Stem Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1scopoletin449.7UGT1A, UGT1A1
2chrysin449.7UGT1A, UGT1A1
3morphine 6-glucuronide449.7UGT1A1, UGT1A
4morphine-3-glucuronide449.7UGT1A1, UGT1A
5sn38 glucuronide449.7UGT1A1, UGT1A
64-methylumbelliferone449.7UGT1A1, UGT1A
71-naphthol449.7UGT1A, UGT1A1
8n-hydroxy phip449.6UGT1A, UGT1A1
9atazanavir44 50 1211.6UGT1A1, UGT1A
10su5416449.6EGFR, BIRC5
11udp glucuronic acid449.6UGT1A, UGT1A1
12lamotrigine44 50 1211.6UGT1A, UGT1A1
13bexarotene44 29 1211.6BIRC5, EGFR
14mithramycin449.6EGFR, BIRC5
15glucuronide449.5UGT1A, UGT1A1
16benzidine449.5UGT1A, UGT1A1
17regorafenib50 1210.5UGT1A1, EGFR, EPHA2
18flunitrazepam29 44 1211.5UGT1A, UGT1A1
19luteolin449.5BIRC5, UGT1A
20pd153035449.4EGFR, BIRC5
21erlotinib44 50 1211.4EGFR, UGT1A1, BIRC5
22silymarin449.4BIRC5, EGFR, UGT1A1
23oxaliplatin44 50 1211.4UGT1A1, EGFR, BIRC5
24flavopiridol44 1210.4EGFR, UGT1A1, BIRC5
25thymidylate449.4BIRC5, EGFR, UGT1A1
26naproxen44 25 1211.3UGT1A1, UGT1A
27apigenin44 2910.3UGT1A1, UGT1A
28flurbiprofen44 29 50 1212.3UGT1A1, UGT1A
29lapatinib44 50 1211.2EGFR, BIRC5
30mycophenolic acid44 50 1211.2BIRC5, UGT1A1, UGT1A
315fluorouracil449.1BIRC5, UGT1A1, EGFR
32troglitazone44 29 60 1212.1BIRC5, UGT1A1, UGT1A
33quercetin44 60 25 1212.1UGT1A1, BIRC5, UGT1A
34sn 3844 6010.1EGFR, UGT1A, UGT1A1
35agar449.1EGFR, BIRC5, EPHA2
36irinotecan44 50 1211.1UGT1A, UGT1A1, EGFR
37nicotine44 29 50 1212.1UGT1A, UGT1A1, BIRC5
38resveratrol44 60 25 1212.1UGT1A, BIRC5, BSG
39phosphoinositide448.9BIRC5, EPHA2, BSG, EGFR
40progesterone44 29 60 25 1212.9EGFR, UGT1A1, BSG, BIRC5
41daidzein448.8UGT1A, BIRC5
42vegf448.7BIRC5, EPHA2, BSG, EGFR
43egcg448.6BIRC5, UGT1A, EGFR, UGT1A1
44curcumin448.6BIRC5, UGT1A1, UGT1A, EGFR
45tamoxifen44 50 29 1211.6UGT1A1, EGFR, UGT1A, BIRC5
46genistein44 29 60 3 25 1213.6EGFR, UGT1A1, BIRC5, UGT1A
47testosterone44 60 25 1211.5EGFR, BIRC5, UGT1A, UGT1A1
48tyrosine448.4UGT1A1, BSG, EPHA2, EGFR, BIRC5
49serine447.9UGT1A, BSG, EGFR, BIRC5, TMPRSS11D
50estrogen447.7EPHA2, UGT1A, UGT1A1, BSG, EGFR, BIRC5

GO Terms for genes affiliated with Brain Stem Glioma

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Cellular components related to Brain Stem Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7EPHA2, TMPRSS11D, BSG, UGT1A1

Biological processes related to Brain Stem Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine phosphorylationGO:0181089.4EGFR, EPHA2
2liver developmentGO:0018899.2EGFR, UGT1A1

Molecular functions related to Brain Stem Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.1EGFR, EPHA2
2protein heterodimerization activityGO:0469829.0EGFR, BIRC5, UGT1A1
3enzyme bindingGO:0198998.9EGFR, BIRC5, UGT1A1

Products for genes affiliated with Brain Stem Glioma

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Sources for Brain Stem Glioma

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4CDC
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26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
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40NDF-RT
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47OMIM via Orphanet
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57SNOMED-CT via Orphanet
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62UMLS via Orphanet