MCID: BRN035
MIFTS: 38

Brain Stem Glioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Brain Stem Glioma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A brainstem glioma is a cancerous glioma tumor in the brainstem. more...

MalaCards: Brain Stem Glioma, also known as brainstem neuroglial tumor, is related to malignant glioma and brain glioma. An important gene associated with Brain Stem Glioma is EPHA2 (EPH receptor A2), and among its related pathways are Stabilization and expansion of the E-cadherin adherens junction and Arf6 signaling events. The compounds resveratrol and Regorafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and pons.

Aliases & Classifications for Brain Stem Glioma

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain stem glioma 8 10
brainstem neuroglial tumor 8
glioma of brainstem 60


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Disease Ontology8 DOID:4202
NCIt39 C8501

Related Diseases for Brain Stem Glioma

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17GeneCards, 18GeneDecks
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Diseases in the Brain Stem Glioma family:

Adult Brain Stem Glioma

Diseases related to Brain Stem Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1malignant glioma30.1BIRC5, EPHA2, EGFR, BSG
2brain glioma11.0
3childhood brain stem glioma10.5
4adult brain stem glioma10.4
5brain disease10.4
6moyamoya disease10.1
7meningoencephalitis10.1
8encephalitis10.1
9hydrocephalus10.1
10panniculitis10.1
11hepatitis10.0UGT1A1
12sarcoma10.0EPHA2
13adenoma10.0BIRC5
14familial adenomatous polyposis10.0BIRC5
15crigler najjar syndrome, type 210.0UGT1A1, UGT1A
16crigler-najjar syndrome10.0UGT1A1, UGT1A
17bilirubin metabolic disorder10.0UGT1A1, UGT1A
18gilbert syndrome10.0UGT1A1
19ependymoma10.0EGFR
20bladder carcinoma10.0BSG
21neutropenia10.0EGFR, UGT1A1
22factor vii deficiency10.0EGFR, UGT1A1
23diarrhea10.0EGFR, UGT1A1
24laryngeal benign neoplasm10.0EGFR, BIRC5
25endometrial carcinoma10.0EGFR, UGT1A1, UGT1A
26bladder carcinoma in situ10.0EGFR, BIRC5
27astrocytoma10.0BSG, EGFR
28squamous cell carcinoma of the head and neck10.0FANCL, EGFR, BIRC5
29hepatocellular carcinoma10.0BSG, UGT1A, UGT1A1, BIRC5
30laryngeal squamous cell carcinoma10.0BSG, EGFR, BIRC5
31pancreatic cancer10.0BSG, EGFR, BIRC5
32transitional cell carcinoma10.0BSG, EGFR, BIRC5
33non-small cell lung carcinoma10.0UGT1A1, EGFR, EPHA2, BIRC5
34cervical cancer10.0BIRC5, EGFR, BSG
35colon cancer10.0UGT1A, EGFR, EPHA2, BIRC5
36stomach cancer10.0BSG, EGFR, BIRC5
37glioblastoma multiforme10.0BSG, EGFR, EPHA2, BIRC5
38kidney cancer10.0BSG, EGFR, EPHA2, BIRC5
39ovarian cancer10.0BIRC5, EPHA2, EGFR, BSG
40prostate cancer10.0BIRC5, EPHA2, EGFR
41lung cancer10.0BIRC5, EGFR, BSG
42squamous cell carcinoma10.0BSG, EGFR, EPHA2, BIRC5
43adenocarcinoma10.0BSG, UGT1A1, EGFR, EPHA2, BIRC5
44colorectal cancer10.0BIRC5, EPHA2, EGFR, UGT1A1, UGT1A, BSG
45breast cancer9.9FANCL, BSG, UGT1A, UGT1A1, EGFR, EPHA2

Graphical network of the top 20 diseases related to Brain Stem Glioma:



Diseases related to brain stem glioma

Clinical Features for Brain Stem Glioma

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Drugs & Therapeutics for Brain Stem Glioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Brain Stem Glioma

Drug clinical trials:

Search ClinicalTrials for Brain Stem Glioma

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Genetic Tests for Brain Stem Glioma

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Anatomical Context for Brain Stem Glioma

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32MalaCards
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MalaCards organs/tissues related to Brain Stem Glioma:

32
Brain, Endothelial, Pons

Animal Models for Brain Stem Glioma or affiliated genes

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Publications for Brain Stem Glioma

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50PubMed
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Articles related to Brain Stem Glioma:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Human brain glioma stem cells are more invasive than their differentiated progeny cells in vitro. (22153826)
2012
2
A simplified and modified procedure to culture brain glioma stem cells from clinical specimens. (22740855)
2012
3
Intracranial syphilitic gumma mimicking a brain stem glioma. (22723064)
2012
4
Treatment of progressive brain stem glioma with bevacizumab: radiological, metabolic and histopathological aspects. (22048887)
2012
5
Expression levels of Fas/Fas-L mRNA in human brain glioma stem cells. (22344564)
2012
6
Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. (21233173)
2011
7
Shall we treat hydrocephalus associated to brain stem glioma in children? (21928037)
2011
8
microRNA-34a is tumor suppressive in brain tumors and glioma stem cells. (20190569)
2010
9
Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype. (21321379)
2010
10
Diffuse brain stem glioma. (20212241)
2010
11
Commentary on diffuse brain stem glioma in children. (19016114)
2008
12
Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma. (18230189)
2008
13
Treatment of children with diffuse intrinsic brain stem glioma with radiotherapy, vincristine and oral VP-16: a Children's Oncology Group phase II study. (17278121)
2008
14
Somatostatin-receptor positive brain stem glioma visualized by octreoscan. (17627256)
2007
15
HSV encephalitis in a child with brain stem glioma: a rare complication of therapy. Case report and review of the neurosurgical literature. (17593375)
2007
16
Chemoresistance of CD133(+) tumor stem cells from human brain glioma]. (17767043)
2007
17
Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma. (17999604)
2007
18
Isolation and culture of tumor stem cells from human brain glioma tissues]. (17044993)
2006
19
Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. (16616334)
2006
20
Irinotecan therapy in a 12-year-old girl with recurrent brain stem glioma and without functional polymorphisms in UGT1A1 activity: case report. (16187025)
2005
21
Biopsy of brain stem glioma using motor-evoked potential mapping by direct peduncular stimulation and individual adjuvant therapy. Case report. (15699622)
2005
22
Brain stem glioma: two case studies. (15695354)
2005
23
ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma. (14506149)
2003
24
Brain stem glioma in a child: false diagnosis of radiation necrosis with FDG PET. (12555260)
2003
25
Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic brain stem glioma: a preliminary report. (12718563)
2003
26
Recurrent haemorrhage from a malignant brain stem glioma: a review of the mechanisms of tumoural haemorrhage. (12948477)
2003
27
Clinical management of brain stem glioma. (10332008)
1999
28
Diffuse brain stem glioma. A review of stereotactic biopsies. (10392494)
1999
29
Neuroimaging of pediatric brain stem diseases other than brain stem glioma. (9075252)
1996
30
Leptomyxid amebic meningoencephalitis mimicking brain stem glioma. (7611076)
1995
31
Bilateral jawline nodules in a child with a brain-stem glioma. Poststeroid panniculitis. (7492138)
1995
32
Quality of survival among children treated for brain stem glioma. (8043460)
1994
33
Intra-arterial chemotherapy for brain stem glioma: report of four cases. (8108006)
1994
34
Radiotherapy for pediatric brain stem glioma: radiation dose, response, and survival. (1407449)
1992
35
Pathological laughter and brain stem glioma. (1640246)
1992
36
Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma. (1902547)
1991
37
Brain stem glioma: the role of a biopsy. (1892569)
1991
38
Prolonged response to carboplatin in an infant with brain stem glioma. (1985722)
1991
39
Hyperfractionated radiation therapy for brain-stem glioma: a phase I-II trial. (2709109)
1989
40
Transient late magnetic resonance imaging changes suggesting progression of brain stem glioma: implications for entry criteria for phase II trials. (3054620)
1988
41
Brain stem glioma mimicking progressive basilar artery thrombosis. (2834522)
1988
42
Brain stem glioma presenting as gastro-oesophageal reflux. (3632023)
1987
43
Orthostatic hypotension with lower brain stem glioma. (7161610)
1982
44
Brain stem glioma in childhood: acute hemiplegic onset. (6269714)
1981
45
Hysterical symptoms masking brain stem glioma. (204623)
1978
46
An unusual case of brain stem glioma with prolonged spontaneous remission and downbeat nystagmus. (4745685)
1973
47
Brain stem glioma causing failure to thrive. (5542786)
1971
48
Clinicopathologic conference. Baptist Memorial Hospital. Brain stem glioma in children. (4313782)
1970
49
Paroxysmal skew deviation in association with a brain stem glioma. Report of an unusual case. (13860590)
1962
50
Gliomas of the brain stem. I. Study of a gangliocytoma of the pons penetrating into the hypothalamic region]. (13079693)
1953

Genetic Variations for Brain Stem Glioma

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Expression for genes affiliated with Brain Stem Glioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Stem Glioma

Search GEO for disease gene expression data for Brain Stem Glioma.

Pathways for genes affiliated with Brain Stem Glioma

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37NCBI BioSystems Database, 49PharmGKB
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Pathways related to Brain Stem Glioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7EPHA2, EGFR
29.7EPHA2, EGFR
39.6EGFR, UGT1A1
4
Hide members
9.6EGFR, UGT1A1

Compounds for genes affiliated with Brain Stem Glioma

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Brain Stem Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1resveratrol44 59 11 2413.2UGT1A
2Regorafenib1110.0EPHA2, UGT1A1
3scopoletin4410.0UGT1A1, UGT1A
4chrysin4410.0UGT1A1, UGT1A
5morphine 6-glucuronide4410.0UGT1A, UGT1A1
6sn38 glucuronide4410.0UGT1A, UGT1A1
7morphine-3-glucuronide4410.0UGT1A1, UGT1A
81-naphthol449.9UGT1A, UGT1A1
94-methylumbelliferone449.9UGT1A1, UGT1A
10n-hydroxy phip449.9UGT1A1, UGT1A
11atazanavir44 49 1111.9UGT1A1, UGT1A
12udp glucuronic acid449.9UGT1A, UGT1A1
13su5416449.9BIRC5, EGFR
14lamotrigine44 1110.9UGT1A, UGT1A1
15glucuronide449.9UGT1A, UGT1A1
16bexarotene44 28 1111.9EGFR, BIRC5
17benzidine449.9UGT1A, UGT1A1
18mithramycin449.9EGFR, BIRC5
19flunitrazepam44 28 1111.9UGT1A1, UGT1A
20pd153035449.8EGFR, BIRC5
21naproxen44 11 2411.8UGT1A, UGT1A1
22luteolin449.8BIRC5, UGT1A
23apigenin44 2810.8UGT1A1, UGT1A
24lapatinib44 49 1111.8BIRC5, EGFR
25phip449.7UGT1A1, UGT1A
26flurbiprofen44 28 49 1112.7UGT1A, UGT1A1
27erlotinib44 49 1111.7EGFR, BIRC5, UGT1A1
28daidzein449.7UGT1A, BIRC5
29silymarin449.7EGFR, UGT1A1, BIRC5
30oxaliplatin44 49 1111.7EGFR, BIRC5, UGT1A1
31flavopiridol44 1110.7BIRC5, EGFR, UGT1A1
32dasatinib44 49 1111.7EGFR, EPHA2
33cotinine44 2410.6UGT1A1, UGT1A
34thymidylate449.6BIRC5, UGT1A1, EGFR
35buprenorphine44 28 1111.6UGT1A, UGT1A1
36mycophenolic acid44 49 1111.6BIRC5, UGT1A, UGT1A1
37troglitazone44 28 59 1112.5BIRC5, UGT1A1, UGT1A
38quercetin44 59 11 2412.5BIRC5, UGT1A1, UGT1A
39sn 3844 5910.5EGFR, UGT1A1, UGT1A
40epothilone b59 44 1111.4BIRC5, EGFR
41irinotecan44 49 1111.4UGT1A1, EGFR, UGT1A
42nicotine44 49 28 1112.4BIRC5, UGT1A, UGT1A1
43flavonoid449.2UGT1A, UGT1A1
44phosphoinositide449.2BSG, EPHA2, EGFR, BIRC5
45curcumin449.0EGFR, UGT1A, UGT1A1, BIRC5
46tamoxifen44 49 28 1112.0EGFR, BIRC5, UGT1A, UGT1A1
47progesterone44 59 28 11 2413.0UGT1A1, EGFR, BIRC5, BSG
48genistein44 28 59 2 11 2414.0UGT1A, EGFR, UGT1A1, BIRC5
49testosterone44 59 11 2411.6EGFR, UGT1A, UGT1A1, BIRC5
50tyrosine448.3BSG, EPHA2, PTPRN2, BIRC5, EGFR, UGT1A1

GO Terms for genes affiliated with Brain Stem Glioma

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16Gene Ontology
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Molecular functions related to Brain Stem Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.4EPHA2, EGFR
2enzyme bindingGO:0198999.2BIRC5, EGFR, UGT1A1

Products for genes affiliated with Brain Stem Glioma

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  • Antibodies
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Sources for Brain Stem Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet