MCID: BRN035
MIFTS: 34

Brain Stem Glioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Brain Stem Glioma

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Wikipedia:63 A brainstem glioma is a cancerous glioma tumor in the brainstem. more...

MalaCards based summary: Brain Stem Glioma, also known as brainstem neuroglial tumor, is related to childhood brain stem glioma and adult brain stem glioma. An important gene associated with Brain Stem Glioma is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are AHR Pathway and Gefitinib Pathway, Pharmacokinetics. The compounds scopoletin and morphine 6-glucuronide have been mentioned in the context of this disorder. Affiliated tissues include brain and spinal cord.

Aliases & Classifications for Brain Stem Glioma

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Brain Stem Glioma, Aliases & Descriptions:

Name: Brain Stem Glioma 9 11
Brainstem Neuroglial Tumor 9
 
Glioma of Brainstem 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:4202
NCIt38 C8501

Related Diseases for Brain Stem Glioma

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Diseases in the Brain Stem Glioma family:

Adult Brain Stem Glioma

Diseases related to Brain Stem Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1childhood brain stem glioma10.5
2adult brain stem glioma10.5
3gilbert syndrome10.4UGT1A1
4crigler-najjar syndrome, type ii10.3UGT1A, UGT1A1
5crigler-najjar syndrome, type i10.3UGT1A1, UGT1A
6bilirubin metabolic disorder10.3UGT1A, UGT1A1
7moyamoya disease10.2
8neurofibromatosis, type 110.2
9hydrocephalus10.2
10neurofibromatosis10.2
11meningoencephalitis10.2
12demyelinating disease10.2
13encephalitis10.2
14panniculitis10.2
15factor vii deficiency10.2UGT1A1, EGFR
16diarrhea10.1EGFR, UGT1A1
17neutropenia10.1UGT1A1, EGFR
18grade iii astrocytoma10.0EGFR, BSG
19endometrial cancer10.0EGFR, UGT1A1, UGT1A
20laryngeal carcinoma10.0EGFR, BIRC5
21bladder cancer, somatic10.0EGFR, BIRC5
22oral cancer9.9BIRC5, EGFR
23squamous cell carcinoma, head and neck9.9EGFR, BIRC5
24ipex syndrome9.8BSG, UGT1A1, UGT1A
25laryngeal squamous cell carcinoma9.8EGFR, BIRC5, BSG
26transitional cell carcinoma9.8EGFR, BIRC5, BSG
27colorectal cancer9.8EGFR, BIRC5, EPHA2
28cervical cancer, somatic9.8BSG, BIRC5, EGFR
29malignant glioma9.8EGFR, BIRC5, BSG
30pancreatic cancer9.7EGFR, BIRC5
31glioblastoma9.7EPHA2, BIRC5, EGFR
32stomach cancer9.7EGFR, BIRC5, BSG
33lung cancer9.7BSG, BIRC5, EGFR
34breast cancer9.7EGFR, BIRC5, BSG
35hepatocellular carcinoma9.6UGT1A, UGT1A1, BSG, BIRC5
36prostate cancer9.6UGT1A, EPHA2, BIRC5, EGFR
37glioblastoma multiforme9.6BSG, EPHA2, BIRC5, EGFR
38kidney cancer9.6BSG, EPHA2, BIRC5, EGFR
39ovarian cancer, somatic9.5BSG, EPHA2, BIRC5, EGFR
40tongue squamous cell carcinoma9.5EGFR, BIRC5, EPHA2, BSG
41adenocarcinoma9.4UGT1A1, BSG, EPHA2, BIRC5, EGFR

Graphical network of the top 20 diseases related to Brain Stem Glioma:



Diseases related to brain stem glioma

Symptoms for Brain Stem Glioma

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Drugs & Therapeutics for Brain Stem Glioma

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Drug clinical trials:

Search ClinicalTrials for Brain Stem Glioma

Search NIH Clinical Center for Brain Stem Glioma

Genetic Tests for Brain Stem Glioma

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Anatomical Context for Brain Stem Glioma

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MalaCards organs/tissues related to Brain Stem Glioma:

31
Brain, Spinal cord

Animal Models for Brain Stem Glioma or affiliated genes

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Publications for Brain Stem Glioma

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Articles related to Brain Stem Glioma:

(show all 50)
idTitleAuthorsYear
1
Brain stem glioma with spinal cord involvement in a young with neurofibromatosis type 1. (24614250)
2014
2
Intracranial syphilitic gumma mimicking a brain stem glioma. (22723064)
2012
3
Treatment of progressive brain stem glioma with bevacizumab: radiological, metabolic and histopathological aspects. (22048887)
2012
4
Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. (21233173)
2011
5
Shall we treat hydrocephalus associated to brain stem glioma in children? (21928037)
2011
6
DTI fiber tracking to differentiate demyelinating diseases from diffuse brain stem glioma. (20363335)
2010
7
Diffuse brain stem glioma. (20212241)
2010
8
Brain stem glioma, a rare cause of hearing loss and dysequilibrium. (21063295)
2008
9
Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas. (18324354)
2008
10
Commentary on diffuse brain stem glioma in children. (19016114)
2008
11
Treatment of children with diffuse intrinsic brain stem glioma with radiotherapy, vincristine and oral VP-16: a Children's Oncology Group phase II study. (17278121)
2008
12
Somatostatin-receptor positive brain stem glioma visualized by octreoscan. (17627256)
2007
13
HSV encephalitis in a child with brain stem glioma: a rare complication of therapy. Case report and review of the neurosurgical literature. (17593375)
2007
14
Irinotecan therapy in a 12-year-old girl with recurrent brain stem glioma and without functional polymorphisms in UGT1A1 activity: case report. (16187025)
2005
15
Biopsy of brain stem glioma using motor-evoked potential mapping by direct peduncular stimulation and individual adjuvant therapy. Case report. (15699622)
2005
16
Brain stem glioma: two case studies. (15695354)
2005
17
ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma. (14506149)
2003
18
Brain stem glioma in a child: false diagnosis of radiation necrosis with FDG PET. (12555260)
2003
19
Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic brain stem glioma: a preliminary report. (12718563)
2003
20
Recurrent haemorrhage from a malignant brain stem glioma: a review of the mechanisms of tumoural haemorrhage. (12948477)
2003
21
Moyamoya disease associated with a brain stem glioma. (10855525)
2000
22
Brain stem glioma--a study of 111 patients. (10921213)
1999
23
Clinical management of brain stem glioma. (10332008)
1999
24
Diffuse brain stem glioma. A review of stereotactic biopsies. (10392494)
1999
25
Neuroimaging of pediatric brain stem diseases other than brain stem glioma. (9075252)
1996
26
Leptomyxid amebic meningoencephalitis mimicking brain stem glioma. (7611076)
1995
27
Bilateral jawline nodules in a child with a brain-stem glioma. Poststeroid panniculitis. (7492138)
1995
28
Quality of survival among children treated for brain stem glioma. (8043460)
1994
29
Intra-arterial chemotherapy for brain stem glioma: report of four cases. (8108006)
1994
30
Brain-stem glioma growth patterns. (8433142)
1993
31
Radiotherapy for pediatric brain stem glioma: radiation dose, response, and survival. (1407449)
1992
32
Pathological laughter and brain stem glioma. (1640246)
1992
33
Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma. (1902547)
1991
34
Brain stem glioma: the role of a biopsy. (1892569)
1991
35
Prolonged response to carboplatin in an infant with brain stem glioma. (1985722)
1991
36
A case of dyschondroplasia associated with brain stem glioma: diagnosis by stereotactic biopsy. (2234348)
1990
37
Nursing care of the child with a brain stem glioma. (2254841)
1990
38
Hyperfractionated radiation therapy for brain-stem glioma: a phase I-II trial. (2709109)
1989
39
Transient late magnetic resonance imaging changes suggesting progression of brain stem glioma: implications for entry criteria for phase II trials. (3054620)
1988
40
Brain stem glioma mimicking progressive basilar artery thrombosis. (2834522)
1988
41
Brain stem glioma presenting as gastro-oesophageal reflux. (3632023)
1987
42
Orthostatic hypotension with lower brain stem glioma. (7161610)
1982
43
Brain stem glioma in childhood: acute hemiplegic onset. (6269714)
1981
44
Brain stem glioma complicated by Strongyloides stercoralis. (7325594)
1981
45
Hysterical symptoms masking brain stem glioma. (204623)
1978
46
Myokymia and facial contraction in brain stem glioma. An electromyographic study. (4827058)
1974
47
An unusual case of brain stem glioma with prolonged spontaneous remission and downbeat nystagmus. (4745685)
1973
48
Brain stem glioma causing failure to thrive. (5542786)
1971
49
Clinicopathologic conference. Baptist Memorial Hospital. Brain stem glioma in children. (4313782)
1970
50
Paroxysmal skew deviation in association with a brain stem glioma. Report of an unusual case. (13860590)
1962

Variations for Brain Stem Glioma

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Expression for genes affiliated with Brain Stem Glioma

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Search GEO for disease gene expression data for Brain Stem Glioma.

Pathways for genes affiliated with Brain Stem Glioma

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Pathways related to Brain Stem Glioma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
AhR pathway36
9.5EGFR, UGT1A1
2
Show member pathways
9.5EGFR, UGT1A1
39.4EPHA2, EGFR
4
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion58
Pathogenic Escherichia coli infection36
Cytoskeleton remodeling Slit Robo signaling
9.4EGFR, EPHA2
59.4EGFR, EPHA2
6
Show member pathways
Signal transduction PTEN pathway58
9.3EGFR, BIRC5
7
Show member pathways
8.9EGFR, BIRC5, EPHA2

Compounds for genes affiliated with Brain Stem Glioma

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Compounds related to Brain Stem Glioma according to GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1scopoletin439.7UGT1A, UGT1A1
2morphine 6-glucuronide439.7UGT1A1, UGT1A
3chrysin439.7UGT1A, UGT1A1
4sn38 glucuronide439.7UGT1A, UGT1A1
5morphine-3-glucuronide439.7UGT1A, UGT1A1
61-naphthol439.7UGT1A, UGT1A1
74-methylumbelliferone439.7UGT1A1, UGT1A
8atazanavir43 49 1211.6UGT1A, UGT1A1
9n-hydroxy phip439.6UGT1A1, UGT1A
10su5416439.6BIRC5, EGFR
11udp glucuronic acid439.6UGT1A, UGT1A1
12bexarotene43 28 1211.6EGFR, BIRC5
13lamotrigine43 49 1211.6UGT1A, UGT1A1
14mithramycin439.6EGFR, BIRC5
15glucuronide439.5UGT1A1, UGT1A
16benzidine439.5UGT1A, UGT1A1
17regorafenib49 1210.5EGFR, EPHA2, UGT1A1
18flunitrazepam28 43 1211.5UGT1A1, UGT1A
19luteolin439.5BIRC5, UGT1A
20pd153035439.4EGFR, BIRC5
21erlotinib43 49 1211.4EGFR, UGT1A1, BIRC5
22silymarin439.4EGFR, BIRC5, UGT1A1
23oxaliplatin43 49 1211.4UGT1A1, EGFR, BIRC5
24flavopiridol43 1210.4UGT1A1, BIRC5, EGFR
25thymidylate439.4BIRC5, UGT1A1, EGFR
26naproxen43 24 1211.3UGT1A, UGT1A1
27lapatinib43 49 1211.3BIRC5, EGFR
28phip439.3UGT1A1, UGT1A
29mycophenolic acid43 49 1211.2BIRC5, UGT1A, UGT1A1
30apigenin43 2810.2UGT1A1, UGT1A
31troglitazone43 28 59 1212.1UGT1A, BIRC5, UGT1A1
325fluorouracil439.1EGFR, UGT1A1, BIRC5
33quercetin43 59 24 1212.1BIRC5, UGT1A1, UGT1A
34sn 3843 5910.1UGT1A, UGT1A1, EGFR
35irinotecan43 49 1211.1EGFR, UGT1A1, UGT1A
36agar439.1EPHA2, BIRC5, EGFR
37nicotine43 28 49 1212.1UGT1A, UGT1A1, BIRC5
38resveratrol43 59 24 1212.1BIRC5, UGT1A, BSG
39phosphoinositide438.9BSG, BIRC5, EPHA2, EGFR
40progesterone43 28 59 24 1212.9BSG, UGT1A1, BIRC5, EGFR
41daidzein438.8BIRC5, UGT1A
42vegf438.7BSG, EPHA2, EGFR, BIRC5
43egcg438.6UGT1A1, EGFR, UGT1A, BIRC5
44curcumin438.6BIRC5, EGFR, UGT1A1, UGT1A
45tamoxifen43 49 28 1211.6UGT1A, UGT1A1, BIRC5, EGFR
46genistein43 28 59 2 24 1213.6UGT1A1, EGFR, BIRC5, UGT1A
47testosterone43 59 24 1211.5EGFR, UGT1A, UGT1A1, BIRC5
48tyrosine438.4EPHA2, EGFR, UGT1A1, BSG, BIRC5
49serine437.9UGT1A, BSG, BIRC5, EGFR, TMPRSS11D
50estrogen437.7EPHA2, BSG, UGT1A, EGFR, UGT1A1, BIRC5

GO Terms for genes affiliated with Brain Stem Glioma

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Cellular components related to Brain Stem Glioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.7EPHA2, TMPRSS11D, BSG, UGT1A1

Biological processes related to Brain Stem Glioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine phosphorylationGO:00181089.4EGFR, EPHA2
2liver developmentGO:00018899.2EGFR, UGT1A1

Molecular functions related to Brain Stem Glioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:00047149.1EGFR, EPHA2
2protein heterodimerization activityGO:00469829.0EGFR, BIRC5, UGT1A1
3enzyme bindingGO:00198998.9EGFR, BIRC5, UGT1A1

Products for genes affiliated with Brain Stem Glioma

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Sources for Brain Stem Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet