MCID: BRN035
MIFTS: 39

Brain Stem Glioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Brain Stem Glioma

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66Wikipedia, 34MalaCards
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Wikipedia:66 A brainstem glioma is a cancerous glioma tumor in the brainstem. more...

MalaCards: Brain Stem Glioma, also known as brainstem neuroglial tumor, is related to childhood brain stem glioma and adult brain stem glioma. An important gene associated with Brain Stem Glioma is UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1), and among its related pathways are AHR Pathway and Gefitinib Pathway, Pharmacokinetics. The compounds scopoletin and chrysin have been mentioned in the context of this disorder. Affiliated tissues include brain.

Aliases & Classifications for Brain Stem Glioma

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9Disease Ontology, 11DISEASES, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

brain stem glioma 9 11
brainstem neuroglial tumor 9
glioma of brainstem 63


External Ids:

Disease Ontology9 DOID:4202
NCIt41 C8501

Related Diseases for Brain Stem Glioma

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18GeneCards, 19GeneDecks
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Diseases in the Brain Stem Glioma family:

Adult Brain Stem Glioma

Diseases related to Brain Stem Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1childhood brain stem glioma10.5
2adult brain stem glioma10.4
3meningoencephalitis10.2
4moyamoya disease10.2
5encephalitis10.2
6hydrocephalus10.2
7panniculitis10.2
8dysphagia10.2
9myokymia10.2
10gilbert syndrome10.1UGT1A1
11crigler najjar syndrome, type 210.1UGT1A, UGT1A1
12crigler-najjar syndrome10.1UGT1A, UGT1A1
13bilirubin metabolic disorder10.1UGT1A, UGT1A1
14factor vii deficiency10.0EGFR, UGT1A1
15diarrhea10.0EGFR, UGT1A1
16neutropenia10.0UGT1A1, EGFR
17endometrial carcinoma10.0EGFR, UGT1A1, UGT1A
18anaplastic astrocytoma10.0EGFR, BSG
19laryngeal benign neoplasm10.0EGFR, BIRC5
20bladder carcinoma in situ10.0EGFR, BIRC5
21pancreatic cancer10.0EGFR, BIRC5
22oral cancer10.0BIRC5, EGFR
23laryngeal squamous cell carcinoma9.9BSG, BIRC5, EGFR
24transitional cell carcinoma9.9EGFR, BIRC5, BSG
25colorectal cancer9.9BIRC5, EPHA2, EGFR
26cervical cancer9.9BSG, BIRC5, EGFR
27malignant glioma9.9EGFR, BIRC5, BSG
28stomach cancer9.9BIRC5, BSG, EGFR
29glioblastoma multiforme9.9EPHA2, BIRC5, EGFR
30lung cancer9.9EGFR, BIRC5, BSG
31ipex syndrome9.9UGT1A, UGT1A1, BSG
32colon cancer9.9UGT1A, EPHA2, BIRC5, EGFR
33hepatocellular carcinoma9.9UGT1A, BIRC5, BSG, UGT1A1
34non-small cell lung carcinoma9.9EGFR, UGT1A1, EPHA2, BIRC5
35breast cancer9.9EGFR, BIRC5, BSG
36bladder carcinoma9.9UGT1A, BSG, BIRC5, EGFR
37prostate cancer9.9EGFR, EPHA2, UGT1A, BIRC5
38kidney cancer9.9BIRC5, EGFR, EPHA2, BSG
39ovarian cancer9.9BIRC5, EGFR, EPHA2, BSG
40tongue squamous cell carcinoma9.9EGFR, BIRC5, BSG, EPHA2
41adenocarcinoma9.9EPHA2, BSG, EGFR, UGT1A1, BIRC5

Graphical network of the top 20 diseases related to Brain Stem Glioma:



Diseases related to brain stem glioma

Symptoms for Brain Stem Glioma

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Drugs & Therapeutics for Brain Stem Glioma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Brain Stem Glioma

Drug clinical trials:

Search ClinicalTrials for Brain Stem Glioma

Search NIH Clinical Center for Brain Stem Glioma

Search CenterWatch for Brain Stem Glioma

Genetic Tests for Brain Stem Glioma

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Anatomical Context for Brain Stem Glioma

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34MalaCards
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MalaCards organs/tissues related to Brain Stem Glioma:

34
Brain

Animal Models for Brain Stem Glioma or affiliated genes

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Publications for Brain Stem Glioma

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53PubMed
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Articles related to Brain Stem Glioma:

(show all 50)
idTitleAuthorsYear
1
Intracranial syphilitic gumma mimicking a brain stem glioma. (22723064)
2012
2
Treatment of progressive brain stem glioma with bevacizumab: radiological, metabolic and histopathological aspects. (22048887)
2012
3
Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. (21233173)
2011
4
Shall we treat hydrocephalus associated to brain stem glioma in children? (21928037)
2011
5
DTI fiber tracking to differentiate demyelinating diseases from diffuse brain stem glioma. (20363335)
2010
6
Diffuse brain stem glioma. (20212241)
2010
7
Brain stem glioma, a rare cause of hearing loss and dysequilibrium. (21063295)
2008
8
Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas. (18324354)
2008
9
Commentary on diffuse brain stem glioma in children. (19016114)
2008
10
Treatment of children with diffuse intrinsic brain stem glioma with radiotherapy, vincristine and oral VP-16: a Children's Oncology Group phase II study. (17278121)
2008
11
Somatostatin-receptor positive brain stem glioma visualized by octreoscan. (17627256)
2007
12
HSV encephalitis in a child with brain stem glioma: a rare complication of therapy. Case report and review of the neurosurgical literature. (17593375)
2007
13
Irinotecan therapy in a 12-year-old girl with recurrent brain stem glioma and without functional polymorphisms in UGT1A1 activity: case report. (16187025)
2005
14
Biopsy of brain stem glioma using motor-evoked potential mapping by direct peduncular stimulation and individual adjuvant therapy. Case report. (15699622)
2005
15
Brain stem glioma: two case studies. (15695354)
2005
16
ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma. (14506149)
2003
17
Brain stem glioma in a child: false diagnosis of radiation necrosis with FDG PET. (12555260)
2003
18
Phase II study of antineoplaston A10 and AS2-1 in patients with recurrent diffuse intrinsic brain stem glioma: a preliminary report. (12718563)
2003
19
Recurrent haemorrhage from a malignant brain stem glioma: a review of the mechanisms of tumoural haemorrhage. (12948477)
2003
20
Moyamoya disease associated with a brain stem glioma. (10855525)
2000
21
Brain stem glioma--a study of 111 patients. (10921213)
1999
22
Clinical management of brain stem glioma. (10332008)
1999
23
Diffuse brain stem glioma. A review of stereotactic biopsies. (10392494)
1999
24
Neuroimaging of pediatric brain stem diseases other than brain stem glioma. (9075252)
1996
25
Leptomyxid amebic meningoencephalitis mimicking brain stem glioma. (7611076)
1995
26
Bilateral jawline nodules in a child with a brain-stem glioma. Poststeroid panniculitis. (7492138)
1995
27
Quality of survival among children treated for brain stem glioma. (8043460)
1994
28
Intra-arterial chemotherapy for brain stem glioma: report of four cases. (8108006)
1994
29
Brain-stem glioma growth patterns. (8433142)
1993
30
Radiotherapy for pediatric brain stem glioma: radiation dose, response, and survival. (1407449)
1992
31
Pathological laughter and brain stem glioma. (1640246)
1992
32
Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma. (1902547)
1991
33
Brain stem glioma: the role of a biopsy. (1892569)
1991
34
Prolonged response to carboplatin in an infant with brain stem glioma. (1985722)
1991
35
A case of dyschondroplasia associated with brain stem glioma: diagnosis by stereotactic biopsy. (2234348)
1990
36
Nursing care of the child with a brain stem glioma. (2254841)
1990
37
Chronic dysphagia, vomiting and gastroesophageal reflux as manifestations of a brain stem glioma: a case report. (2488955)
1989
38
Hyperfractionated radiation therapy for brain-stem glioma: a phase I-II trial. (2709109)
1989
39
Transient late magnetic resonance imaging changes suggesting progression of brain stem glioma: implications for entry criteria for phase II trials. (3054620)
1988
40
Brain stem glioma mimicking progressive basilar artery thrombosis. (2834522)
1988
41
Brain stem glioma presenting as gastro-oesophageal reflux. (3632023)
1987
42
Orthostatic hypotension with lower brain stem glioma. (7161610)
1982
43
Brain stem glioma in childhood: acute hemiplegic onset. (6269714)
1981
44
Brain stem glioma complicated by Strongyloides stercoralis. (7325594)
1981
45
Hysterical symptoms masking brain stem glioma. (204623)
1978
46
Myokymia and facial contraction in brain stem glioma. An electromyographic study. (4827058)
1974
47
An unusual case of brain stem glioma with prolonged spontaneous remission and downbeat nystagmus. (4745685)
1973
48
Brain stem glioma causing failure to thrive. (5542786)
1971
49
Clinicopathologic conference. Baptist Memorial Hospital. Brain stem glioma in children. (4313782)
1970
50
Paroxysmal skew deviation in association with a brain stem glioma. Report of an unusual case. (13860590)
1962

Variations for Brain Stem Glioma

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Expression for genes affiliated with Brain Stem Glioma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brain Stem Glioma

Search GEO for disease gene expression data for Brain Stem Glioma.

Pathways for genes affiliated with Brain Stem Glioma

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 52PharmGKB, 61Thomson Reuters, 13EMD Millipore, 31KEGG
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Compounds for genes affiliated with Brain Stem Glioma

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Brain Stem Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1scopoletin469.7UGT1A, UGT1A1
2chrysin469.7UGT1A, UGT1A1
3morphine 6-glucuronide469.7UGT1A1, UGT1A
4morphine-3-glucuronide469.7UGT1A1, UGT1A
5sn38 glucuronide469.7UGT1A1, UGT1A
64-methylumbelliferone469.7UGT1A1, UGT1A
71-naphthol469.7UGT1A, UGT1A1
8n-hydroxy phip469.6UGT1A, UGT1A1
9atazanavir46 52 1211.6UGT1A1, UGT1A
10su5416469.6EGFR, BIRC5
11udp glucuronic acid469.6UGT1A, UGT1A1
12lamotrigine46 52 1211.6UGT1A, UGT1A1
13bexarotene46 30 1211.6BIRC5, EGFR
14mithramycin469.6EGFR, BIRC5
15glucuronide469.5UGT1A, UGT1A1
16benzidine469.5UGT1A, UGT1A1
17regorafenib52 1210.5UGT1A1, EGFR, EPHA2
18flunitrazepam30 46 1211.5UGT1A, UGT1A1
19luteolin469.5BIRC5, UGT1A
20pd153035469.4EGFR, BIRC5
21erlotinib46 52 1211.4EGFR, UGT1A1, BIRC5
22silymarin469.4BIRC5, EGFR, UGT1A1
23oxaliplatin46 52 1211.4UGT1A1, EGFR, BIRC5
24flavopiridol46 1210.4EGFR, UGT1A1, BIRC5
25thymidylate469.4BIRC5, EGFR, UGT1A1
26naproxen46 25 1211.3UGT1A1, UGT1A
27apigenin46 3010.3UGT1A1, UGT1A
28flurbiprofen46 30 52 1212.3UGT1A1, UGT1A
29lapatinib46 52 1211.2EGFR, BIRC5
30mycophenolic acid46 52 1211.2BIRC5, UGT1A1, UGT1A
315fluorouracil469.1BIRC5, UGT1A1, EGFR
32troglitazone46 30 62 1212.1BIRC5, UGT1A1, UGT1A
33quercetin46 62 25 1212.1UGT1A1, BIRC5, UGT1A
34sn 3846 6210.1EGFR, UGT1A, UGT1A1
35agar469.1EGFR, BIRC5, EPHA2
36irinotecan46 52 1211.1UGT1A, UGT1A1, EGFR
37nicotine46 30 52 1212.1UGT1A, UGT1A1, BIRC5
38resveratrol46 62 25 1212.1UGT1A, BIRC5, BSG
39phosphoinositide468.9BIRC5, EPHA2, BSG, EGFR
40progesterone46 30 62 25 1212.9EGFR, UGT1A1, BSG, BIRC5
41daidzein468.8UGT1A, BIRC5
42vegf468.7BIRC5, EPHA2, BSG, EGFR
43egcg468.6BIRC5, UGT1A, EGFR, UGT1A1
44curcumin468.6BIRC5, UGT1A1, UGT1A, EGFR
45tamoxifen46 52 30 1211.6UGT1A1, EGFR, UGT1A, BIRC5
46genistein46 30 62 3 25 1213.6EGFR, UGT1A1, BIRC5, UGT1A
47testosterone46 62 25 1211.5EGFR, BIRC5, UGT1A, UGT1A1
48tyrosine468.4UGT1A1, BSG, EPHA2, EGFR, BIRC5
49serine467.9UGT1A, BSG, EGFR, BIRC5, TMPRSS11D
50estrogen467.7EPHA2, UGT1A, UGT1A1, BSG, EGFR, BIRC5

GO Terms for genes affiliated with Brain Stem Glioma

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17Gene Ontology
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Cellular components related to Brain Stem Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7EPHA2, TMPRSS11D, BSG, UGT1A1

Biological processes related to Brain Stem Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidyl-tyrosine phosphorylationGO:0181089.4EGFR, EPHA2
2liver developmentGO:0018899.2EGFR, UGT1A1

Molecular functions related to Brain Stem Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.1EGFR, EPHA2
2protein heterodimerization activityGO:0469829.0EGFR, BIRC5, UGT1A1
3enzyme bindingGO:0198998.9EGFR, BIRC5, UGT1A1

Products for genes affiliated with Brain Stem Glioma

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  • Antibodies
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Sources for Brain Stem Glioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet