HBOC
MCID: BRC016
MIFTS: 24

Brca1 and Brca2 Hereditary Breast and Ovarian Cancer (HBOC) malady

Categories: Genetic diseases, Cancer diseases

Aliases & Classifications for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Aliases & Descriptions for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

Name: Brca1 and Brca2 Hereditary Breast and Ovarian Cancer 24
Hboc 24

Classifications:



Summaries for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

MalaCards based summary : Brca1 and Brca2 Hereditary Breast and Ovarian Cancer, also known as hboc, is related to brca2 hereditary breast and ovarian cancer syndrome and hereditary breast ovarian cancer. An important gene associated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer is BRCA2 (BRCA2, DNA Repair Associated), and among its related pathways/superpathways are Integrated Breast Cancer Pathway and DNA Damage. The drugs Letrozole and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include breast, and related phenotypes are Decreased viability with paclitaxel and homeostasis/metabolism

Related Diseases for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Graphical network of the top 20 diseases related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:



Diseases related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Symptoms & Phenotypes for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

GenomeRNAi Phenotypes related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 PHB PPM1D
2 Decreased viability with paclitaxel GR00179-A-2 8.92 PPM1D
3 Decreased viability with paclitaxel GR00179-A-3 8.92 PPM1D

MGI Mouse Phenotypes related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 NQO2 PHB PIK3CA PPM1D BRCA2
2 endocrine/exocrine gland MP:0005379 9.62 PHB PIK3CA PPM1D BRCA2
3 integument MP:0010771 9.55 PHB PIK3CA PPM1D BRCA2 NQO2
4 neoplasm MP:0002006 9.26 PIK3CA PPM1D BRCA2 NQO2
5 reproductive system MP:0005389 8.92 PHB PIK3CA PPM1D BRCA2

Drugs & Therapeutics for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Drugs for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
2 Hormone Antagonists Phase 3,Phase 2
3 Hormones Phase 3,Phase 2
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
5 Estrogen Antagonists Phase 3,Phase 2
6 Estrogens Phase 3,Phase 2
7 Steroid Synthesis Inhibitors Phase 3
8 Aromatase Inhibitors Phase 3
9
Zoledronic acid Approved Phase 2 118072-93-8 68740
10
Tamoxifen Approved Phase 2 10540-29-1 2733526
11
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
12
Olaparib Approved Phase 1, Phase 2 763113-22-0 23725625
13
Docetaxel Approved May 1996, Investigational Phase 2 114977-28-5 148124 9877265
14 Diphosphonates Phase 2
15 Bone Density Conservation Agents Phase 2
16 Selective Estrogen Receptor Modulators Phase 2
17 Estrogen Receptor Modulators Phase 2
18 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
19 Antimitotic Agents Phase 2,Phase 1
20 Antineoplastic Agents, Hormonal Phase 2
21
tremelimumab Phase 1, Phase 2
22 Immunoglobulins Phase 1, Phase 2
23 Antibodies, Monoclonal Phase 1, Phase 2
24 Antibodies Phase 1, Phase 2
25 Citrate Nutraceutical Phase 2
26
Citric Acid Nutraceutical, Vet_approved Phase 2 77-92-9 311
27
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
28
Vinblastine Approved Phase 1 865-21-4 13342 241903
29
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
30
Vinorelbine Approved, Investigational Phase 1 71486-22-1 60780 44424639
31
Veliparib Investigational Phase 1 912444-00-9 11960529
32 Albumin-Bound Paclitaxel Phase 1
33 Antineoplastic Agents, Phytogenic Phase 1
34
Pancrelipase Approved 53608-75-6
35 pancreatin

Interventional clinical trials:

(show all 34)
id Name Status NCT ID Phase
1 Standard Genetic Counseling With or Without a Decision Guide in Improving Communication Between Mothers Undergoing BRCA1/2 Testing and Their Minor-Age Children Completed NCT00685256 Phase 3
2 Methods in Education for Breast Cancer Genetics Active, not recruiting NCT00001806 Phase 3
3 Letrozole in Preventing Breast Cancer in Postmenopausal Women With a BRCA1 or BRCA2 Mutation Active, not recruiting NCT00673335 Phase 3
4 Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers Not yet recruiting NCT03162276 Phase 3
5 Zoledronate or Observation in Maintaining Bone Mineral Density in Patients Who Are Undergoing Surgery to Remove Both Ovaries Unknown status NCT00305695 Phase 2
6 Search Allelic Imbalance of Expression of BRCA Genes in Hereditary Risk of Breast and/or Ovarian Cancer Completed NCT01333748 Phase 2
7 Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers Completed NCT01367639 Phase 2
8 Arzoxifene or Tamoxifen in Preventing Breast Cancer in Premenopausal Women at High Risk for Breast Cancer Completed NCT00253539 Phase 2
9 Carboplatin or Docetaxel in Treating Women With Metastatic Genetic Breast Cancer Completed NCT00321633 Phase 2
10 PARP-inhibition and CTLA-4 Blockade in BRCA-deficient Ovarian Cancer Recruiting NCT02571725 Phase 1, Phase 2
11 Veliparib, Carboplatin, and Paclitaxel in Treating Patients With Advanced Solid Cancer Completed NCT00535119 Phase 1
12 Veliparib in Treating Patients With Malignant Solid Tumors That Do Not Respond to Previous Therapy Active, not recruiting NCT00892736 Phase 1
13 Veliparib, Cisplatin, and Vinorelbine Ditartrate in Treating Patients With Recurrent and/or Metastatic Breast Cancer Active, not recruiting NCT01104259 Phase 1
14 Thymidine Kinase 1 in Risk Assessment for Hereditary Breast /Ovarian Cancer Unknown status NCT00855998
15 Outcomes After Perforator Flap Reconstruction for Breast Reconstruction and/or Lymphedema Treatment Unknown status NCT01273909
16 Short Non-coding RNA Biomarkers of Predisposition to Ovarian Cancer Unknown status NCT01187602
17 Cancer Genetics Hereditary Cancer Panel Testing Completed NCT02324062
18 Risk Education and Assessment for Cancer Heredity Completed NCT01346761
19 Lessons Learned From the Family Gene Toolkit Completed NCT02154633
20 Outcomes of Education and Counseling for BRCA1 Testing Completed NCT00001468
21 A Qualitative Exploration of the Impact of Positive BRCA1/2 Mutation Status on the Lives of Young Women Completed NCT00858078
22 Adaptation to Living With a BRCA1/2 Mutation Completed NCT01866865
23 Removal of the Ovaries/Fallopian Tubes and CA-125 Screening to Reduce the Risk of Ovarian Cancer in Women at Increased Genetic Risk Completed NCT00043472
24 Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier Registry Recruiting NCT02302742
25 Pancreatic Cancer Genetics Recruiting NCT01102569
26 Specimen and Data Study for Ovarian Cancer Early Detection and Prevention Recruiting NCT00005095
27 C-PATROL - Non-interventional Study (NIS) to Collect Clinical and Patient Reported Outcome Data in an Olaparib Treated BRCAm+ PSR Ovarian Cancer Population Recruiting NCT02503436
28 Analysis of Tumors From Patients With Inherited Cancers Having Had Two Surgeries (Primary + Recurrent, or 2 Separate Types of Cancer) Recruiting NCT01167842
29 Targeted Next-generation Sequencing Panel for Identification of Germline Mutations in Early Onset Cancers With Sporadic or Hereditary Presentation Recruiting NCT02664389
30 Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer Active, not recruiting NCT00040222
31 Culturally-Informed Counseling in Latinas at High Risk for Hereditary Breast or Ovarian Cancer Active, not recruiting NCT01230346
32 Genetic Counseling for Breast Cancer Survivors (GC for BC) Active, not recruiting NCT02451735
33 Decision Support Following Genetic Testing for Breast-Ovarian Cancer Susceptibility Enrolling by invitation NCT02133703
34 Family Communication of Hereditary Breast and Ovarian Cancer Risk Among African Americans Terminated NCT01374685

Search NIH Clinical Center for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Genetic Tests for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Genetic tests related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

id Genetic test Affiliating Genes
1 Brca1 and Brca2 Hereditary Breast and Ovarian Cancer 24 BRCA2

Anatomical Context for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

MalaCards organs/tissues related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

39
Breast

Publications for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Articles related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

id Title Authors Year
1
BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer ( 20301425 )
1993

Variations for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Expression for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Search GEO for disease gene expression data for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer.

Pathways for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Pathways related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.34 BRCA2 PHB
2 11.26 BRCA2 PHB PPM1D
3
Show member pathways
11.1 BRCA2 PIK3CA

GO Terms for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Biological processes related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 8.62 NQO2 PHB

Molecular functions related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein C-terminus binding GO:0008022 8.62 BRCA2 PHB

Sources for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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