HBOC
MCID: BRC016
MIFTS: 35

Brca1 and Brca2 Hereditary Breast and Ovarian Cancer (HBOC) malady

Genetic diseases (common), Cancer diseases categories

Summaries for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
Sources:
20GeneReviews, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MalaCards: Brca1 and Brca2 Hereditary Breast and Ovarian Cancer, also known as HBOC, is related to ovarian cancer and lynch syndrome. An important gene associated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer is BRCA2 (breast cancer 2, early onset), and among its related pathways are Meiosis and Chks in Checkpoint Regulation. The compounds 8-oxoguanine and daidzein have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

GeneReviews summary for brca1

Aliases & Classifications for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
Sources:
20GeneReviews, 21GeneTests, 23GTR
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases


Aliases & Descriptions:

brca1 and brca2 hereditary breast and ovarian cancer 20 21 23
hboc 20


Related Diseases for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:



Diseases related to brca1 and brca2 hereditary breast and ovarian cancer

Symptoms for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section

Drugs & Therapeutics for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Drug clinical trials:

Search ClinicalTrials for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Search NIH Clinical Center for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Search CenterWatch for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Genetic Tests for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
Sources:
21GeneTests, 23GTR
See all sources

Genetic tests related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

id Genetic test Affiliating Genes
1 Brca1 and Brca2 Hereditary Breast and Ovarian Cancer21 23 BRCA2

Anatomical Context for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

34
Breast

Animal Models for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0BRCA2, BRCA1, PALB2
2MP:00020068.5PALB2, BRCA1, BRCA2, NQO2
3MP:00107718.5NQO2, BRCA2, BRCA1, PALB2
4MP:00053978.1RAD54L, BRCA1, BRCA2, NQO2
5MP:00053768.1RAD54L, BRCA1, BRCA2, NQO2
6MP:00053878.0RAD54L, BRCA1, BRCA2, NQO2
7MP:00053847.9BRCA2, BRCA1, PALB2, RAD54L

Publications for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
Sources:
53PubMed
See all sources

Articles related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

idTitleAuthorsYear
1
BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer (20301425)
1993

Variations for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
Sources:
1 National Center for Biotechnology Information (Clinvar)
See all sources

Clinvar genetic disease variations for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

1 (show all 93)
id Gene Name Type Significance SNP ID Assembly Location
1BRCA1NM_007294.3(BRCA1): c.181T> G (p.Cys61Gly)single nucleotide variantPathogenicrs28897672GRCh37Chr 17, 41258504: 41258504
2BRCA1NM_007294.3(BRCA1): c.68_69delAG (p.Glu23Valfs)deletionPathogenic, risk factorrs80357713GRCh37Chr 17, 41276047: 41276048
3BRCA1NM_007294.3(BRCA1): c.1175_1214del40 (p.Leu392Glnfs)deletionLikely pathogenic, Pathogenicrs80359874GRCh37Chr 17, 41246334: 41246373
4BRCA1NM_007294.3(BRCA1): c.2681_2682delAA (p.Lys894Thrfs)deletionPathogenicrs80357971GRCh37Chr 17, 41244866: 41244867
5BRCA1NM_007294.3(BRCA1): c.3005delA (p.Asn1002Thrfs)deletionPathogenicrs80357601GRCh38Chr 17, 43092526: 43092526
6BRCA1NM_007294.3(BRCA1): c.3119G> A (p.Ser1040Asn)single nucleotide variantBenign, Likely benign, Pathogenic, Uncertain significancers4986852GRCh37Chr 17, 41244429: 41244429
7BRCA1NM_007294.3(BRCA1): c.3607C> T (p.Arg1203Ter)single nucleotide variantPathogenicrs62625308GRCh37Chr 17, 41243941: 41243941
8BRCA1NM_007294.3(BRCA1): c.3748G> T (p.Glu1250Ter)single nucleotide variantPathogenicrs28897686GRCh37Chr 17, 41243800: 41243800
9BRCA1NM_007294.3(BRCA1): c.4327C> T (p.Arg1443Ter)single nucleotide variantPathogenicrs41293455GRCh37Chr 17, 41234451: 41234451
10BRCA1NM_007294.3(BRCA1): c.5266dupC (p.Gln1756Profs)duplicationPathogenic, risk factorrs80357906GRCh37Chr 17, 41209083: 41209083
11BRCA1NM_007294.3(BRCA1): c.2521C> T (p.Arg841Trp)single nucleotide variantBenign, Likely benign, Pathogenic, Uncertain significancers1800709GRCh37Chr 17, 41245027: 41245027
12BRCA1NM_007294.3(BRCA1): c.1687C> T (p.Gln563Ter)single nucleotide variantPathogenicrs80356898GRCh37Chr 17, 41245861: 41245861
13BRCA1NM_007294.3(BRCA1): c.213-11T> Gsingle nucleotide variantPathogenicrs80358061GRCh37Chr 17, 41256984: 41256984
14BRCA1NM_007294.3(BRCA1): c.2411_2412delAG (p.Gln804Leufs)deletionPathogenicrs80357664GRCh37Chr 17, 41245136: 41245137
15BRCA1NM_007294.3(BRCA1): c.3485delA (p.Asp1162Valfs)deletionPathogenicrs80357509GRCh37Chr 17, 41244063: 41244063
16BRCA1NM_007294.3(BRCA1): c.3700_3704delGTAAA (p.Val1234Glnfs)deletionPathogenicrs80357609GRCh37Chr 17, 41243844: 41243848
17BRCA1NM_007294.3(BRCA1): c.4035delA (p.Glu1346Lysfs)deletionPathogenicrs80357711GRCh37Chr 17, 41243513: 41243513
18BRCA1NM_007294.3(BRCA1): c.427G> A (p.Glu143Lys)single nucleotide variantLikely benign, Pathogenic, Uncertain significancers80356991GRCh37Chr 17, 41256153: 41256153
19BRCA1NM_007294.3(BRCA1): c.427G> T (p.Glu143Ter)single nucleotide variantPathogenicrs80356991GRCh37Chr 17, 41256153: 41256153
20BRCA1NM_007294.3(BRCA1): c.4484G> T (p.Arg1495Met)single nucleotide variantPathogenicrs80357389GRCh37Chr 17, 41228505: 41228505
21BRCA1NM_007294.3(BRCA1): c.4689C> G (p.Tyr1563Ter)single nucleotide variantPathogenicrs80357433GRCh37Chr 17, 41223242: 41223242
22BRCA1NM_007294.3(BRCA1): c.4964_4982del19 (p.Ser1655Tyrfs)deletionPathogenicrs80359876GRCh37Chr 17, 41222949: 41222967
23BRCA1NM_007294.3(BRCA1): c.4986+6T> Csingle nucleotide variantLikely pathogenic, Pathogenicrs80358086GRCh37Chr 17, 41222939: 41222939
24BRCA1NM_007294.3(BRCA1): c.5259delA (p.Glu1754Asnfs)deletionPathogenicrs80357925GRCh37Chr 17, 41209087: 41209087
25BRCA1NM_007294.3(BRCA1): c.5335delC (p.Gln1779Asnfs)deletionPathogenicrs80357590GRCh37Chr 17, 41201209: 41201209
26BRCA1NM_007294.3(BRCA1): c.547+2T> Asingle nucleotide variantPathogenicrs80358047GRCh37Chr 17, 41251790: 41251790
27BRCA1NM_007294.3(BRCA1): c.594-2A> Csingle nucleotide variantPathogenic, Uncertain significancers80358033GRCh37Chr 17, 41247941: 41247941
28BRCA1NM_007294.3(BRCA1): c.676delT (p.Cys226Valfs)deletionPathogenicrs80357941GRCh37Chr 17, 41246872: 41246872
29BRCA1NM_007294.3(BRCA1): c.962G> A (p.Trp321Ter)single nucleotide variantPathogenicrs80357292GRCh37Chr 17, 41246586: 41246586
30BRCA2NM_000059.3(BRCA2): c.1813dupA (p.Ile605Asnfs)duplicationPathogenicrs80359308GRCh37Chr 13, 32907428: 32907428
31BRCA2NM_000059.3(BRCA2): c.2808_2811delACAA (p.Ala938Profs)deletionPathogenicrs80359352GRCh37Chr 13, 32911300: 32911303
32BRCA2NM_000059.3(BRCA2): c.3109C> T (p.Gln1037Ter)single nucleotide variantPathogenicrs80358557GRCh37Chr 13, 32911601: 32911601
33BRCA2NM_000059.3(BRCA2): c.3717delA (p.Lys1239Asnfs)deletionPathogenicrs80359401GRCh37Chr 13, 32912209: 32912209
34BRCA2NM_000059.3(BRCA2): c.3847_3848delGT (p.Val1283Lysfs)deletionPathogenicrs80359405GRCh37Chr 13, 32912339: 32912340
35BRCA2NM_000059.3(BRCA2): c.4284dupT (p.Gln1429Serfs)duplicationPathogenicrs80359440GRCh37Chr 13, 32912776: 32912776
36BRCA2NM_000059.3(BRCA2): c.4415_4418delAGAA (p.Lys1472Thrfs)deletionPathogenicrs397507333GRCh37Chr 13, 32912907: 32912910
37BRCA2NM_000059.3(BRCA2): c.4472_4475delTGAA (p.Leu1491Glnfs)deletionPathogenicrs80359452GRCh37Chr 13, 32912964: 32912967
38BRCA2NM_000059.3(BRCA2): c.4631delA (p.Asn1544Thrfs)deletionPathogenicrs80359461GRCh37Chr 13, 32913123: 32913123
39BRCA2NM_000059.3(BRCA2): c.4638delT (p.Phe1546Leufs)deletionPathogenicrs80359462GRCh37Chr 13, 32913130: 32913130
40BRCA2NM_000059.3(BRCA2): c.4876_4877delAA (p.Asn1626Serfs)deletionPathogenicrs80359470GRCh37Chr 13, 32913368: 32913369
41BRCA2NM_000059.3(BRCA2): c.5073dupA (p.Trp1692Metfs)duplicationPathogenicrs80359480GRCh37Chr 13, 32913565: 32913565
42BRCA2NM_000059.3(BRCA2): c.5576_5579delTTAA (p.Ile1859Lysfs)deletionPathogenicrs80359521GRCh37Chr 13, 32914068: 32914071
43BRCA2NM_000059.3(BRCA2): c.5655C> A (p.Cys1885Ter)single nucleotide variantPathogenicrs80358789GRCh37Chr 13, 32914147: 32914147
44BRCA2NM_000059.3(BRCA2): c.5682C> G (p.Tyr1894Ter)single nucleotide variantPathogenicrs41293497GRCh37Chr 13, 32914174: 32914174
45BRCA2NM_000059.3(BRCA2): c.5782G> T (p.Glu1928Ter)single nucleotide variantPathogenicrs56253082GRCh37Chr 13, 32914274: 32914274
46BRCA2NM_000059.3(BRCA2): c.5799_5802delCCAA (p.Asn1933Lysfs)deletionPathogenicrs80359538GRCh37Chr 13, 32914291: 32914294
47BRCA2NM_000059.3(BRCA2): c.6405_6409delCTTAA (p.Asn2135Lysfs)deletionPathogenicrs80359585GRCh37Chr 13, 32914897: 32914901
48BRCA2NM_000059.3(BRCA2): c.6468_6469delTC (p.Gln2157Ilefs)deletionPathogenicrs80359597GRCh37Chr 13, 32914960: 32914961
49BRCA2NM_000059.3(BRCA2): c.7007G> A (p.Arg2336His)single nucleotide variantLikely pathogenic, Pathogenicrs28897743GRCh37Chr 13, 32921033: 32921033
50BRCA2NM_000059.3(BRCA2): c.7977-1G> Csingle nucleotide variantPathogenicrs81002874GRCh37Chr 13, 32937315: 32937315
51BRCA2NM_000059.3(BRCA2): c.8297delC (p.Thr2766Asnfs)deletionPathogenicrs80359705GRCh37Chr 13, 32937636: 32937636
52BRCA2NM_000059.3(BRCA2): c.9117G> A (p.Pro3039=)single nucleotide variantLikely pathogenic, Pathogenicrs28897756GRCh37Chr 13, 32954050: 32954050
53BRCA2NM_000059.3(BRCA2): c.5482_5486delAAATT (p.Lys1828Valfs)deletionPathogenicrs80359516GRCh37Chr 13, 32913974: 32913978
54BRCA2NM_000059.3(BRCA2): c.1389_1390delAG (p.Val464Glyfs)deletionPathogenicrs80359283GRCh37Chr 13, 32907004: 32907005
55BRCA2NM_000059.3(BRCA2): c.1773_1776delTTAT (p.Ile591Metfs)deletionPathogenicrs80359305GRCh37Chr 13, 32907388: 32907391
56BRCA2NM_000059.3(BRCA2): c.2812_2815delGCAA (p.Ala938Profs)deletionPathogenicrs80359354GRCh37Chr 13, 32911304: 32911307
57BRCA2NM_000059.3(BRCA2): c.2957dupA (p.Asn986Lysfs)duplicationPathogenicrs80359365GRCh37Chr 13, 32911449: 32911450
58BRCA2NM_000059.3(BRCA2): c.316+5G> Asingle nucleotide variantPathogenic, Uncertain significancers81002840GRCh37Chr 13, 32893467: 32893467
59BRCA2NM_000059.3(BRCA2): c.4398_4402delACATT (p.Leu1466Phefs)deletionPathogenicrs80359444GRCh37Chr 13, 32912890: 32912894
60BRCA2NM_000059.3(BRCA2): c.4965delC (p.Tyr1655Terfs)deletionPathogenicrs80359475GRCh37Chr 13, 32913457: 32913457
61BRCA2NM_000059.3(BRCA2): c.6446_6450delTTAAA (p.Ile2149Serfs)deletionPathogenicrs80359593GRCh37Chr 13, 32914938: 32914942
62BRCA2NM_000059.3(BRCA2): c.7251_7252delCA (p.His2417Glnfs)deletionPathogenicrs397507907GRCh37Chr 13, 32929241: 32929242
63BRCA2NM_000059.3(BRCA2): c.7617+1G> Asingle nucleotide variantPathogenicrs397507922GRCh37Chr 13, 32930747: 32930747
64BRCA2NM_000059.3(BRCA2): c.772C> T (p.Gln258Ter)single nucleotide variantPathogenicrs80358998GRCh37Chr 13, 32905146: 32905146
65BRCA2NM_000059.3(BRCA2): c.7762delA (p.Ile2588Tyrfs)deletionPathogenicrs80359679GRCh37Chr 13, 32932023: 32932023
66BRCA2NM_000059.3(BRCA2): c.8167G> C (p.Asp2723His)single nucleotide variantPathogenic, Uncertain significancers41293511GRCh37Chr 13, 32937506: 32937506
67BRCA2NM_000059.3(BRCA2): c.8770G> T (p.Glu2924Ter)single nucleotide variantPathogenicrs80359133GRCh37Chr 13, 32953469: 32953469
68BRCA2NM_000059.3(BRCA2): c.9154C> T (p.Arg3052Trp)single nucleotide variantPathogenic, Uncertain significancers45580035GRCh37Chr 13, 32954180: 32954180
69BRCA2NM_000059.3(BRCA2): c.9275_9278delATTT (p.Tyr3092Cysfs)deletionPathogenicrs80359754GRCh37Chr 13, 32968844: 32968847
70BRCA2NM_000059.3(BRCA2): c.9382C> T (p.Arg3128Ter)single nucleotide variantPathogenicrs80359212GRCh37Chr 13, 32968951: 32968951
71BRCA2NM_000059.3(BRCA2): c.9924C> G (p.Tyr3308Ter)single nucleotide variantPathogenicrs4987049GRCh37Chr 13, 32972574: 32972574
72BRCA1NM_007294.3(BRCA1): c.1439dupA (p.Asn480Lysfs)duplicationPathogenicrs80357505GRCh37Chr 17, 41246108: 41246109
73BRCA1NM_007294.3(BRCA1): c.1881_1884delCAGT (p.Ser628Glufs)deletionPathogenicrs80357567GRCh37Chr 17, 41245664: 41245667
74BRCA1NM_007294.3(BRCA1): c.2443delA (p.Ile815Phefs)deletionPathogenicrs80357598GRCh37Chr 17, 41245105: 41245105
75BRCA1NM_007294.3(BRCA1): c.2999delA (p.Glu1000Glyfs)deletionPathogenicrs80357991GRCh37Chr 17, 41244549: 41244549
76BRCA1NM_007294.3(BRCA1): c.302-2delAdeletionPathogenicrs273899695GRCh37Chr 17, 41256280: 41256280
77BRCA1NM_007294.3(BRCA1): c.3598C> T (p.Gln1200Ter)single nucleotide variantPathogenicrs62625307GRCh37Chr 17, 41243950: 41243950
78BRCA1NM_007294.3(BRCA1): c.3668_3671dupTTCC (p.Cys1225Serfs)duplicationPathogenicrs80357797GRCh37Chr 17, 41243877: 41243880
79BRCA1NM_007294.3(BRCA1): c.390C> A (p.Tyr130Ter)single nucleotide variantPathogenicrs80356888GRCh37Chr 17, 41256190: 41256190
80BRCA1NM_007294.3(BRCA1): c.4986+3G> Csingle nucleotide variantPathogenic, Uncertain significancers80358023GRCh37Chr 17, 41222942: 41222942
81BRCA1NM_007294.3(BRCA1): c.5095C> T (p.Arg1699Trp)single nucleotide variantPathogenicrs55770810GRCh37Chr 17, 41215948: 41215948
82BRCA1NM_007294.3(BRCA1): c.5137delG (p.Val1713Terfs)deletionPathogenicrs80357997GRCh37Chr 17, 41215906: 41215906
83BRCA1NM_007294.3(BRCA1): c.5152+1G> Tsingle nucleotide variantPathogenicrs80358094GRCh37Chr 17, 41215890: 41215890
84BRCA1NM_007294.3(BRCA1): c.5319dupC (p.Asn1774Glnfs)duplicationPathogenicrs80357823GRCh37Chr 17, 41203092: 41203093
85BRCA1NM_007294.3(BRCA1): c.5558dupA (p.Tyr1853Terfs)duplicationPathogenicrs80357629GRCh37Chr 17, 41197728: 41197729
86BRCA1NM_007294.3(BRCA1): c.3761_3762insTT (p.Lys1254Asnfs)insertionPathogenicrs80357928GRCh37Chr 17, 41243786: 41243787
87BRCA2NM_000059.3(BRCA2): c.6275_6276delTT (p.Leu2092Profs)deletionPathogenicrs11571658GRCh37Chr 13, 32914767: 32914768
88BRCA2NM_000059.3(BRCA2): c.6591_6592delTG (p.Glu2198Asnfs)deletionPathogenicrs80359605GRCh37Chr 13, 32915083: 32915084
89BRCA2NM_000059.3(BRCA2): c.5722_5723delCT (p.Leu1908Argfs)deletionPathogenicrs80359531GRCh37Chr 13, 32914214: 32914215
90BRCA2NM_000059.3(BRCA2): c.5946delT (p.Ser1982Argfs)deletionPathogenic, risk factorrs80359550GRCh37Chr 13, 32914438: 32914438
91BRCA2NM_000059.3(BRCA2): c.8537_8538delAG (p.Glu2846Glyfs)deletionPathogenicrs80359716GRCh37Chr 13, 32945142: 32945143
92BRCA2NM_000059.3(BRCA2): c.658_659delGT (p.Val220Ilefs)deletionPathogenic, risk factorrs80359604GRCh37Chr 13, 32903606: 32903607
93BRCA2NM_000059.3(BRCA2): c.4976_4977insG (p.Tyr1661Leufs)insertionPathogenicrs431825325GRCh37Chr 13, 32913468: 32913469

Expression for genes affiliated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

Search GEO for disease gene expression data for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer.

Pathways for genes affiliated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
Sources:
51PathCards, 13EMD Millipore, 56Reactome, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters
See all sources

Pathways related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5BRCA2, BRCA1
2
Show member pathways
9.5BRCA1, BRCA2
3
Show member pathways
Signaling Pathways in Glioblastoma39
9.5BRCA1, BRCA2
49.5BRCA1, BRCA2
5
Show member pathways
9.5BRCA2, BRCA1
69.5BRCA1, BRCA2
7
Show member pathways
9.5BRCA2, BRCA1
8
Show member pathways
Homologous recombination39
9.2BRCA2, RAD54L
99.1RAD54L, BRCA1
109.0BRCA1, PALB2, BRCA2
11
Show member pathways
9.0BRCA1, BRCA2, PALB2
12
Show member pathways
9.0BRCA2, PALB2, BRCA1
138.7BRCA1, BRCA2, RAD54L

Compounds for genes affiliated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
Sources:
46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 3BitterDB, 30IUPHAR, 62Tocris Bioscience
See all sources

Compounds related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
18-oxoguanine469.9BRCA2, BRCA1
2daidzein469.8BRCA2, BRCA1
3lycopene46 2510.8BRCA1, BRCA2
4indole-3-carbinol469.8BRCA1, BRCA2
5methylmethanesulfonate469.8BRCA2, BRCA1
64-hydroxytamoxifen469.8BRCA1, BRCA2
7bleomycin46 1210.8BRCA2, BRCA1
8adpribose469.8BRCA1, BRCA2
9hydroxyurea46 52 1211.8BRCA2, BRCA1
10mitomycin c469.8BRCA1, BRCA2
11p003469.7BRCA1, BRCA2
12vincristine46 52 1211.7BRCA2, BRCA1
13p002469.7BRCA1, BRCA2
14adriamycin469.7BRCA1, BRCA2
15benzo(a)pyrene469.7BRCA1, NQO2
16gold469.6BRCA2, BRCA1
17chloroquine46 3 52 30 1213.6BRCA1, NQO2
18camptothecin46 62 1211.6BRCA1, BRCA2
19docetaxel46 52 62 1212.6BRCA1, BRCA2
20polyacrylamide469.5BRCA1, BRCA2
21folate469.4BRCA1, BRCA2
22cyclophosphamide46 52 1211.3NQO2, BRCA1
23resveratrol46 62 25 1212.2BRCA1, BRCA2, NQO2
24methotrexate52 46 1211.2BRCA1, BRCA2

GO Terms for genes affiliated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.0PALB2, BRCA2, BRCA1
2nucleolusGO:0057308.0NQO2, BRCA2, PALB2, RAD54L
3nucleusGO:0056347.2RAD54L, NQO2, BRCA2, BRCA1, PALB2

Biological processes related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-strand break repairGO:0063029.5BRCA1, BRCA2
2inner cell mass cell proliferationGO:0018339.5BRCA2, PALB2
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4BRCA1, BRCA2
4response to ionizing radiationGO:0102128.8RAD54L, BRCA1
5double-strand break repair via homologous recombinationGO:0007248.3RAD54L, PALB2, BRCA1, BRCA2
6DNA repairGO:0062818.2BRCA2, BRCA1, PALB2, RAD54L

Products for genes affiliated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet