HBOC
MCID: BRC016
MIFTS: 36

Brca1 and Brca2 Hereditary Breast and Ovarian Cancer (HBOC) malady

Genetic diseases (common), Cancer diseases categories
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Summaries for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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MalaCards based summary: Brca1 and Brca2 Hereditary Breast and Ovarian Cancer, also known as HBOC, is related to ovarian cancer and lynch syndrome. An important gene associated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer is BRCA2 (breast cancer 2, early onset), and among its related pathways are BRCA1 Pathway and Homologous Recombination Repair. The compounds 8-oxoguanine and daidzein have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are tumorigenesis and integument.

GeneReviews summary for brca1

Aliases & Classifications for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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Brca1 and Brca2 Hereditary Breast and Ovarian Cancer, Aliases & Descriptions:

Name: Brca1 and Brca2 Hereditary Breast and Ovarian Cancer 19 20 22
 
Hboc 19


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases


Related Diseases for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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Graphical network of the top 20 diseases related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:



Diseases related to brca1 and brca2 hereditary breast and ovarian cancer

Symptoms for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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Drugs & Therapeutics for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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Drug clinical trials:

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Genetic Tests for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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Genetic tests related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

id Genetic test Affiliating Genes
1 Brca1 and Brca2 Hereditary Breast and Ovarian Cancer20 22 BRCA2

Anatomical Context for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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MalaCards organs/tissues related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

32
Breast

Animal Models for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer or affiliated genes

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MGI Mouse Phenotypes related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5NQO2, BRCA2, BRCA1, PALB2
2MP:00107718.1PHB, PALB2, BRCA1, BRCA2, NQO2
3MP:00107688.0PHB, RAD54L, PALB2, BRCA1, BRCA2
4MP:00053767.9NQO2, BRCA2, BRCA1, RAD54L, PHB

Publications for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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Articles related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

idTitleAuthorsYear
1
BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer (20301425)
1993

Variations for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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Clinvar genetic disease variations for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer:

6 (show all 99)
id Gene Name Type Significance SNP ID Assembly Location
1BRCA2NM_000059.3: c.1-?_67+?deldeletionPathogenicGRCh37Chr 13, 32890470: 32890470
2BRCA2NM_000059.3(BRCA2): c.3777delT (p.Leu1260Tyrfs)deletionPathogenicGRCh37Chr 13, 32912269: 32912269
3BRCA2NM_000059.3(BRCA2): c.484delG (p.Ser163Valfs)deletionPathogenicGRCh37Chr 13, 32900387: 32900387
4BRCA2NM_000059.3(BRCA2): c.6562dupA (p.Asn2189Lysfs)duplicationPathogenicGRCh38Chr 13, 32340916: 32340917
5BRCA1NM_007294.3(BRCA1): c.2506delG (p.Glu836Lysfs)deletionPathogenicGRCh37Chr 17, 41245042: 41245042
6BRCA1NM_007294.3(BRCA1): c.3874delT (p.Ser1292Leufs)deletionPathogenicGRCh37Chr 17, 41243674: 41243674
7BRCA1NM_007294.3(BRCA1): c.81-2A> Csingle nucleotide variantPathogenicGRCh37Chr 17, 41267798: 41267798
8BRCA1NM_007294.3(BRCA1): c.181T> G (p.Cys61Gly)single nucleotide variantPathogenicrs28897672GRCh37Chr 17, 41258504: 41258504
9BRCA1NM_007294.3(BRCA1): c.68_69delAG (p.Glu23Valfs)deletionPathogenicrs80357713GRCh37Chr 17, 41276047: 41276048
10BRCA1NM_007294.3(BRCA1): c.1175_1214del40 (p.Leu392Glnfs)deletionLikely pathogenicrs80359874GRCh37Chr 17, 41246334: 41246373
11BRCA1NM_007294.3(BRCA1): c.2681_2682delAA (p.Lys894Thrfs)deletionPathogenicrs80357971GRCh37Chr 17, 41244866: 41244867
12BRCA1NM_007294.3(BRCA1): c.3005delA (p.Asn1002Thrfs)deletionPathogenicrs80357601GRCh38Chr 17, 43092526: 43092526
13BRCA1NM_007294.3(BRCA1): c.3607C> T (p.Arg1203Ter)single nucleotide variantPathogenicrs62625308GRCh37Chr 17, 41243941: 41243941
14BRCA1NM_007294.3(BRCA1): c.3748G> T (p.Glu1250Ter)single nucleotide variantPathogenicrs28897686GRCh37Chr 17, 41243800: 41243800
15BRCA1NM_007294.3(BRCA1): c.4327C> T (p.Arg1443Ter)single nucleotide variantPathogenicrs41293455GRCh37Chr 17, 41234451: 41234451
16BRCA1NM_007294.3(BRCA1): c.5266dupC (p.Gln1756Profs)duplicationPathogenicrs80357906GRCh37Chr 17, 41209083: 41209083
17BRCA1NM_007294.3(BRCA1): c.1687C> T (p.Gln563Ter)single nucleotide variantPathogenicrs80356898GRCh37Chr 17, 41245861: 41245861
18BRCA1NM_007294.3(BRCA1): c.213-11T> Gsingle nucleotide variantPathogenicrs80358061GRCh37Chr 17, 41256984: 41256984
19BRCA1NM_007294.3(BRCA1): c.2411_2412delAG (p.Gln804Leufs)deletionPathogenicrs80357664GRCh37Chr 17, 41245136: 41245137
20BRCA1NM_007294.3(BRCA1): c.3485delA (p.Asp1162Valfs)deletionPathogenicrs80357509GRCh37Chr 17, 41244063: 41244063
21BRCA1NM_007294.3(BRCA1): c.3700_3704delGTAAA (p.Val1234Glnfs)deletionPathogenicrs80357609GRCh37Chr 17, 41243844: 41243848
22BRCA1NM_007294.3(BRCA1): c.4035delA (p.Glu1346Lysfs)deletionPathogenicrs80357711GRCh37Chr 17, 41243513: 41243513
23BRCA1NM_007294.3(BRCA1): c.427G> T (p.Glu143Ter)single nucleotide variantPathogenicrs80356991GRCh37Chr 17, 41256153: 41256153
24BRCA1NM_007294.3(BRCA1): c.4484G> T (p.Arg1495Met)single nucleotide variantPathogenicrs80357389GRCh37Chr 17, 41228505: 41228505
25BRCA1NM_007294.3(BRCA1): c.4689C> G (p.Tyr1563Ter)single nucleotide variantPathogenicrs80357433GRCh37Chr 17, 41223242: 41223242
26BRCA1NM_007294.3(BRCA1): c.4964_4982del19 (p.Ser1655Tyrfs)deletionPathogenicrs80359876GRCh37Chr 17, 41222949: 41222967
27BRCA1NM_007294.3(BRCA1): c.4986+6T> Csingle nucleotide variantLikely pathogenicrs80358086GRCh37Chr 17, 41222939: 41222939
28BRCA1NM_007294.3(BRCA1): c.5259delA (p.Glu1754Asnfs)deletionPathogenicrs80357925GRCh37Chr 17, 41209087: 41209087
29BRCA1NM_007294.3(BRCA1): c.5335delC (p.Gln1779Asnfs)deletionPathogenicrs80357590GRCh37Chr 17, 41201209: 41201209
30BRCA1NM_007294.3(BRCA1): c.547+2T> Asingle nucleotide variantPathogenicrs80358047GRCh37Chr 17, 41251790: 41251790
31BRCA1NM_007294.3(BRCA1): c.594-2A> Csingle nucleotide variantPathogenicrs80358033GRCh37Chr 17, 41247941: 41247941
32BRCA1NM_007294.3(BRCA1): c.676delT (p.Cys226Valfs)deletionPathogenicrs80357941GRCh37Chr 17, 41246872: 41246872
33BRCA1NM_007294.3(BRCA1): c.962G> A (p.Trp321Ter)single nucleotide variantPathogenicrs80357292GRCh37Chr 17, 41246586: 41246586
34BRCA2NM_000059.3(BRCA2): c.1813dupA (p.Ile605Asnfs)duplicationPathogenicrs80359308GRCh37Chr 13, 32907428: 32907428
35BRCA2NM_000059.3(BRCA2): c.2808_2811delACAA (p.Ala938Profs)deletionPathogenicrs80359352GRCh37Chr 13, 32911300: 32911303
36BRCA2NM_000059.3(BRCA2): c.3109C> T (p.Gln1037Ter)single nucleotide variantPathogenicrs80358557GRCh37Chr 13, 32911601: 32911601
37BRCA2NM_000059.3(BRCA2): c.3717delA (p.Lys1239Asnfs)deletionPathogenicrs80359401GRCh37Chr 13, 32912209: 32912209
38BRCA2NM_000059.3(BRCA2): c.3847_3848delGT (p.Val1283Lysfs)deletionPathogenicrs80359405GRCh37Chr 13, 32912339: 32912340
39BRCA2NM_000059.3(BRCA2): c.4284dupT (p.Gln1429Serfs)duplicationPathogenicrs80359440GRCh37Chr 13, 32912776: 32912776
40BRCA2NM_000059.3(BRCA2): c.4415_4418delAGAA (p.Lys1472Thrfs)deletionPathogenicrs397507333GRCh37Chr 13, 32912907: 32912910
41BRCA2NM_000059.3(BRCA2): c.4472_4475delTGAA (p.Leu1491Glnfs)deletionPathogenicrs80359452GRCh37Chr 13, 32912964: 32912967
42BRCA2NM_000059.3(BRCA2): c.4631delA (p.Asn1544Thrfs)deletionPathogenicrs80359461GRCh37Chr 13, 32913123: 32913123
43BRCA2NM_000059.3(BRCA2): c.4638delT (p.Phe1546Leufs)deletionPathogenicrs80359462GRCh37Chr 13, 32913130: 32913130
44BRCA2NM_000059.3(BRCA2): c.4876_4877delAA (p.Asn1626Serfs)deletionPathogenicrs80359470GRCh37Chr 13, 32913368: 32913369
45BRCA2NM_000059.3(BRCA2): c.5073dupA (p.Trp1692Metfs)duplicationPathogenicrs80359480GRCh37Chr 13, 32913565: 32913565
46BRCA2NM_000059.3(BRCA2): c.5576_5579delTTAA (p.Ile1859Lysfs)deletionPathogenicrs80359521GRCh37Chr 13, 32914068: 32914071
47BRCA2NM_000059.3(BRCA2): c.5655C> A (p.Cys1885Ter)single nucleotide variantPathogenicrs80358789GRCh37Chr 13, 32914147: 32914147
48BRCA2NM_000059.3(BRCA2): c.5682C> G (p.Tyr1894Ter)single nucleotide variantPathogenicrs41293497GRCh37Chr 13, 32914174: 32914174
49BRCA2NM_000059.3(BRCA2): c.5782G> T (p.Glu1928Ter)single nucleotide variantPathogenicrs56253082GRCh37Chr 13, 32914274: 32914274
50BRCA2NM_000059.3(BRCA2): c.5799_5802delCCAA (p.Asn1933Lysfs)deletionPathogenicrs80359538GRCh37Chr 13, 32914291: 32914294
51BRCA2NM_000059.3(BRCA2): c.6405_6409delCTTAA (p.Asn2135Lysfs)deletionPathogenicrs80359585GRCh37Chr 13, 32914897: 32914901
52BRCA2NM_000059.3(BRCA2): c.6468_6469delTC (p.Gln2157Ilefs)deletionPathogenicrs80359597GRCh37Chr 13, 32914960: 32914961
53BRCA2NM_000059.3(BRCA2): c.7007G> A (p.Arg2336His)single nucleotide variantLikely pathogenicrs28897743GRCh37Chr 13, 32921033: 32921033
54BRCA2NM_000059.3(BRCA2): c.7977-1G> Csingle nucleotide variantPathogenicrs81002874GRCh37Chr 13, 32937315: 32937315
55BRCA2NM_000059.3(BRCA2): c.8297delC (p.Thr2766Asnfs)deletionPathogenicrs80359705GRCh37Chr 13, 32937636: 32937636
56BRCA2NM_000059.3(BRCA2): c.9117G> A (p.Pro3039=)single nucleotide variantLikely pathogenicrs28897756GRCh37Chr 13, 32954050: 32954050
57BRCA2NM_000059.3(BRCA2): c.5482_5486delAAATT (p.Lys1828Valfs)deletionPathogenicrs80359516GRCh37Chr 13, 32913974: 32913978
58BRCA2NM_000059.3(BRCA2): c.1189_1190insTTAG (p.Gln397Leufs)insertionPathogenicrs397515635GRCh37Chr 13, 32906804: 32906805
59BRCA2NM_000059.3(BRCA2): c.1389_1390delAG (p.Val464Glyfs)deletionPathogenicrs80359283GRCh37Chr 13, 32907004: 32907005
60BRCA2NM_000059.3(BRCA2): c.1773_1776delTTAT (p.Ile591Metfs)deletionPathogenicrs80359305GRCh37Chr 13, 32907388: 32907391
61BRCA2NM_000059.3(BRCA2): c.2812_2815delGCAA (p.Ala938Profs)deletionPathogenicrs80359354GRCh37Chr 13, 32911304: 32911307
62BRCA2NM_000059.3(BRCA2): c.2957dupA (p.Asn986Lysfs)duplicationPathogenicrs80359365GRCh37Chr 13, 32911449: 32911450
63BRCA2NM_000059.3(BRCA2): c.316+5G> Asingle nucleotide variantPathogenicrs81002840GRCh37Chr 13, 32893467: 32893467
64BRCA2NM_000059.3(BRCA2): c.4398_4402delACATT (p.Leu1466Phefs)deletionPathogenicrs80359444GRCh37Chr 13, 32912890: 32912894
65BRCA2NM_000059.3(BRCA2): c.4965delC (p.Tyr1655Terfs)deletionPathogenicrs80359475GRCh37Chr 13, 32913457: 32913457
66BRCA2NM_000059.3(BRCA2): c.6446_6450delTTAAA (p.Ile2149Serfs)deletionPathogenicrs80359593GRCh37Chr 13, 32914938: 32914942
67BRCA2NM_000059.3(BRCA2): c.7251_7252delCA (p.His2417Glnfs)deletionPathogenicrs397507907GRCh37Chr 13, 32929241: 32929242
68BRCA2NM_000059.3(BRCA2): c.7617+1G> Asingle nucleotide variantPathogenicrs397507922GRCh37Chr 13, 32930747: 32930747
69BRCA2NM_000059.3(BRCA2): c.772C> T (p.Gln258Ter)single nucleotide variantPathogenicrs80358998GRCh37Chr 13, 32905146: 32905146
70BRCA2NM_000059.3(BRCA2): c.7762delA (p.Ile2588Tyrfs)deletionPathogenicrs80359679GRCh37Chr 13, 32932023: 32932023
71BRCA2NM_000059.3(BRCA2): c.8167G> C (p.Asp2723His)single nucleotide variantPathogenicrs41293511GRCh37Chr 13, 32937506: 32937506
72BRCA2NM_000059.3(BRCA2): c.8770G> T (p.Glu2924Ter)single nucleotide variantPathogenicrs80359133GRCh37Chr 13, 32953469: 32953469
73BRCA2NM_000059.3(BRCA2): c.9154C> T (p.Arg3052Trp)single nucleotide variantPathogenicrs45580035GRCh37Chr 13, 32954180: 32954180
74BRCA2NM_000059.3(BRCA2): c.9275_9278delATTT (p.Tyr3092Cysfs)deletionPathogenicrs80359754GRCh37Chr 13, 32968844: 32968847
75BRCA2NM_000059.3(BRCA2): c.9382C> T (p.Arg3128Ter)single nucleotide variantPathogenicrs80359212GRCh37Chr 13, 32968951: 32968951
76BRCA2NM_000059.3(BRCA2): c.9924C> G (p.Tyr3308Ter)single nucleotide variantPathogenicrs4987049GRCh37Chr 13, 32972574: 32972574
77BRCA1NM_007294.3(BRCA1): c.1439dupA (p.Asn480Lysfs)duplicationPathogenicrs80357505GRCh37Chr 17, 41246108: 41246109
78BRCA1NM_007294.3(BRCA1): c.1881_1884delCAGT (p.Ser628Glufs)deletionPathogenicrs80357567GRCh37Chr 17, 41245664: 41245667
79BRCA1NM_007294.3(BRCA1): c.2443delA (p.Ile815Phefs)deletionPathogenicrs80357598GRCh37Chr 17, 41245105: 41245105
80BRCA1NM_007294.3(BRCA1): c.2836_2837delAT (p.Ile946Glnfs)deletionPathogenicrs397509016GRCh37Chr 17, 41244711: 41244712
81BRCA1NM_007294.3(BRCA1): c.2999delA (p.Glu1000Glyfs)deletionPathogenicrs80357991GRCh37Chr 17, 41244549: 41244549
82BRCA1NM_007294.3(BRCA1): c.302-2delAdeletionPathogenicrs273899695GRCh37Chr 17, 41256280: 41256280
83BRCA1NM_007294.3(BRCA1): c.3598C> T (p.Gln1200Ter)single nucleotide variantPathogenicrs62625307GRCh37Chr 17, 41243950: 41243950
84BRCA1NM_007294.3(BRCA1): c.3668_3671dupTTCC (p.Cys1225Serfs)duplicationPathogenicrs80357797GRCh37Chr 17, 41243877: 41243880
85BRCA1NM_007294.3(BRCA1): c.390C> A (p.Tyr130Ter)single nucleotide variantPathogenicrs80356888GRCh37Chr 17, 41256190: 41256190
86BRCA1NM_007294.3(BRCA1): c.4986+3G> Csingle nucleotide variantPathogenicrs80358023GRCh37Chr 17, 41222942: 41222942
87BRCA1NM_007294.3(BRCA1): c.5095C> T (p.Arg1699Trp)single nucleotide variantPathogenicrs55770810GRCh37Chr 17, 41215948: 41215948
88BRCA1NM_007294.3(BRCA1): c.5137delG (p.Val1713Terfs)deletionPathogenicrs80357997GRCh37Chr 17, 41215906: 41215906
89BRCA1NM_007294.3(BRCA1): c.5152+1G> Tsingle nucleotide variantPathogenicrs80358094GRCh37Chr 17, 41215890: 41215890
90BRCA1NM_007294.3(BRCA1): c.5319dupC (p.Asn1774Glnfs)duplicationPathogenicrs80357823GRCh37Chr 17, 41203092: 41203093
91BRCA1NM_007294.3(BRCA1): c.5558dupA (p.Tyr1853Terfs)duplicationPathogenicrs80357629GRCh37Chr 17, 41197728: 41197729
92BRCA1NM_007294.3(BRCA1): c.3761_3762insTT (p.Lys1254Asnfs)insertionPathogenicrs80357928GRCh37Chr 17, 41243786: 41243787
93BRCA2NM_000059.3(BRCA2): c.6275_6276delTT (p.Leu2092Profs)deletionPathogenicrs11571658GRCh37Chr 13, 32914767: 32914768
94BRCA2NM_000059.3(BRCA2): c.6591_6592delTG (p.Glu2198Asnfs)deletionPathogenicrs80359605GRCh37Chr 13, 32915083: 32915084
95BRCA2NM_000059.3(BRCA2): c.5722_5723delCT (p.Leu1908Argfs)deletionPathogenicrs80359531GRCh37Chr 13, 32914214: 32914215
96BRCA2NM_000059.3(BRCA2): c.5946delT (p.Ser1982Argfs)deletionPathogenicrs80359550GRCh37Chr 13, 32914438: 32914438
97BRCA2NM_000059.3(BRCA2): c.8537_8538delAG (p.Glu2846Glyfs)deletionPathogenicrs80359716GRCh37Chr 13, 32945142: 32945143
98BRCA2NM_000059.3(BRCA2): c.658_659delGT (p.Val220Ilefs)deletionPathogenicrs80359604GRCh37Chr 13, 32903606: 32903607
99BRCA2NM_000059.3(BRCA2): c.4976_4977insG (p.Tyr1661Leufs)insertionPathogenicrs431825325GRCh37Chr 13, 32913468: 32913469

Expression for genes affiliated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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Expression patterns in normal tissues for genes affiliated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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Pathways for genes affiliated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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Pathways related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7BRCA1, BRCA2
2
Show member pathways
9.7BRCA1, BRCA2
3
Show member pathways
9.7BRCA1, BRCA2
49.7BRCA2, BRCA1
59.5RAD54L, BRCA1
6
Show member pathways
9.2PHB, BRCA1, BRCA2
79.1PALB2, BRCA1, BRCA2
8
Show member pathways
9.1BRCA2, BRCA1, PALB2
9
Show member pathways
9.1BRCA2, BRCA1, PALB2
10
Show member pathways
Homologous recombination37
8.8RAD54L, XRCC3, BRCA2
117.8PHB, RAD54L, XRCC3, BRCA1, BRCA2

Compounds for genes affiliated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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Compounds related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
18-oxoguanine4410.0BRCA2, BRCA1
2daidzein4410.0BRCA2, BRCA1
3lycopene44 2411.0BRCA1, BRCA2
4indole-3-carbinol4410.0BRCA1, BRCA2
5methylmethanesulfonate4410.0BRCA2, BRCA1
64-hydroxytamoxifen449.9BRCA1, BRCA2
7bleomycin44 1110.9BRCA1, BRCA2
8benzo(a)pyrene449.9BRCA1, NQO2
9adpribose449.8BRCA1, BRCA2
10leptomycin b44 6110.8PHB, BRCA1
11hydroxyurea44 50 1111.8BRCA1, BRCA2
12chloroquine44 2 50 28 1113.8NQO2, BRCA1
13adriamycin449.7BRCA1, BRCA2
14vincristine44 50 1111.6BRCA1, BRCA2
15resveratrol44 61 24 1112.6BRCA1, BRCA2, NQO2
16p002449.4BRCA1, BRCA2
17mitomycin c449.2XRCC3, BRCA1, BRCA2
18p003449.2BRCA2, BRCA1, XRCC3
19docetaxel44 50 61 1112.2BRCA2, BRCA1, XRCC3
20folate449.2XRCC3, BRCA1, BRCA2
21steroid449.2BRCA2, BRCA1, PHB
22cisplatin44 50 61 1112.1BRCA2, BRCA1, XRCC3
23camptothecin44 61 1110.7PHB, XRCC3, BRCA1, BRCA2

GO Terms for genes affiliated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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Cellular components related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.4BRCA2, BRCA1, PALB2, PHB
2nucleolusGO:0057308.2NQO2, BRCA2, PALB2, RAD54L
3cytoplasmGO:0057377.9PHB, XRCC3, BRCA1, BRCA2, NQO2
4nucleusGO:0056346.7PHB, RAD54L, XRCC3, PALB2, BRCA1, BRCA2

Biological processes related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.8BRCA1, BRCA2
2inner cell mass cell proliferationGO:0018339.6BRCA2, PALB2
3double-strand break repairGO:0063029.6BRCA2, BRCA1
4response to ionizing radiationGO:0102129.5RAD54L, BRCA1
5DNA recombinationGO:0063109.1RAD54L, XRCC3
6positive regulation of transcription, DNA-templatedGO:0458938.9PHB, BRCA1, BRCA2
7double-strand break repair via homologous recombinationGO:0007247.9RAD54L, XRCC3, PALB2, BRCA1, BRCA2
8DNA repairGO:0062817.9BRCA2, BRCA1, PALB2, XRCC3, RAD54L

Molecular functions related to Brca1 and Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.2PHB, RAD54L, XRCC3, PALB2, BRCA1, BRCA2

Products for genes affiliated with Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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  • Antibodies
  • Proteins
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Sources for Brca1 and Brca2 Hereditary Breast and Ovarian Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet