MCID: BRC055
MIFTS: 30

Brca2 Hereditary Breast and Ovarian Cancer malady

Genetic diseases (common), Cancer diseases categories

Summaries for Brca2 Hereditary Breast and Ovarian Cancer

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MalaCards: Brca2 Hereditary Breast and Ovarian Cancer, also known as malignant neoplasms, is related to brca1 and brca2 hereditary breast and ovarian cancer and ovarian cancer. An important gene associated with Brca2 Hereditary Breast and Ovarian Cancer is BRCA2 (breast cancer 2, early onset), and among its related pathways are Meiosis and Chks in Checkpoint Regulation. The compounds 8-oxoguanine and daidzein have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Aliases & Classifications for Brca2 Hereditary Breast and Ovarian Cancer

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21GeneTests, 63UMLS
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Classifications:

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Global: Genetic diseases (common), Cancer diseases


Aliases & Descriptions:

brca2 hereditary breast and ovarian cancer 21
malignant neoplasms 63


Related Diseases for Brca2 Hereditary Breast and Ovarian Cancer

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Brca2 Hereditary Breast and Ovarian Cancer:



Diseases related to brca2 hereditary breast and ovarian cancer

Symptoms for Brca2 Hereditary Breast and Ovarian Cancer

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Drugs & Therapeutics for Brca2 Hereditary Breast and Ovarian Cancer

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Genetic Tests for Brca2 Hereditary Breast and Ovarian Cancer

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21GeneTests
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Genetic tests related to Brca2 Hereditary Breast and Ovarian Cancer:

id Genetic test Affiliating Genes
1 Brca2 Hereditary Breast and Ovarian Cancer21 BRCA2

Anatomical Context for Brca2 Hereditary Breast and Ovarian Cancer

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34MalaCards
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MalaCards organs/tissues related to Brca2 Hereditary Breast and Ovarian Cancer:

34
Breast

Animal Models for Brca2 Hereditary Breast and Ovarian Cancer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Brca2 Hereditary Breast and Ovarian Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0BRCA2, BRCA1, PALB2
2MP:00020068.5NQO2, BRCA2, BRCA1, PALB2
3MP:00107718.5NQO2, BRCA2, BRCA1, PALB2
4MP:00053978.1RAD54L, BRCA1, BRCA2, NQO2
5MP:00053768.1RAD54L, BRCA1, NQO2, BRCA2
6MP:00053878.0RAD54L, BRCA1, BRCA2, NQO2
7MP:00053847.9PALB2, BRCA1, BRCA2, RAD54L

Publications for Brca2 Hereditary Breast and Ovarian Cancer

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53PubMed
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Articles related to Brca2 Hereditary Breast and Ovarian Cancer:

idTitleAuthorsYear
1
BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer (20301425)
1993

Variations for Brca2 Hereditary Breast and Ovarian Cancer

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Expression for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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Pathways for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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51PathCards, 13EMD Millipore, 56Reactome, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters
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Pathways related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5BRCA2, BRCA1
2
Show member pathways
9.5BRCA1, BRCA2
3
Show member pathways
Signaling Pathways in Glioblastoma39
9.5BRCA1, BRCA2
49.5BRCA1, BRCA2
5
Show member pathways
9.5BRCA2, BRCA1
69.5BRCA1, BRCA2
7
Show member pathways
9.5BRCA2, BRCA1
8
Show member pathways
Homologous recombination39
9.2BRCA2, RAD54L
99.1RAD54L, BRCA1
109.0BRCA1, PALB2, BRCA2
11
Show member pathways
9.0BRCA1, BRCA2, PALB2
12
Show member pathways
9.0BRCA2, PALB2, BRCA1
138.7BRCA1, BRCA2, RAD54L

Compounds for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 3BitterDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
18-oxoguanine469.9BRCA2, BRCA1
2daidzein469.8BRCA2, BRCA1
3lycopene46 2510.8BRCA1, BRCA2
4indole-3-carbinol469.8BRCA1, BRCA2
5methylmethanesulfonate469.8BRCA2, BRCA1
64-hydroxytamoxifen469.8BRCA1, BRCA2
7bleomycin46 1210.8BRCA2, BRCA1
8adpribose469.8BRCA1, BRCA2
9hydroxyurea46 52 1211.8BRCA2, BRCA1
10mitomycin c469.8BRCA1, BRCA2
11p003469.7BRCA1, BRCA2
12vincristine46 52 1211.7BRCA2, BRCA1
13p002469.7BRCA1, BRCA2
14adriamycin469.7BRCA1, BRCA2
15benzo(a)pyrene469.7BRCA1, NQO2
16gold469.6BRCA2, BRCA1
17chloroquine46 3 52 30 1213.6BRCA1, NQO2
18camptothecin46 62 1211.6BRCA1, BRCA2
19docetaxel46 52 62 1212.6BRCA1, BRCA2
20polyacrylamide469.5BRCA1, BRCA2
21folate469.4BRCA1, BRCA2
22cyclophosphamide46 52 1211.3NQO2, BRCA1
23resveratrol46 62 25 1212.2BRCA1, BRCA2, NQO2
24methotrexate52 46 1211.2BRCA1, BRCA2

GO Terms for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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17Gene Ontology
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Cellular components related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.0PALB2, BRCA2, BRCA1
2nucleolusGO:0057308.0NQO2, BRCA2, PALB2, RAD54L
3nucleusGO:0056347.2RAD54L, NQO2, BRCA2, BRCA1, PALB2

Biological processes related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-strand break repairGO:0063029.5BRCA1, BRCA2
2inner cell mass cell proliferationGO:0018339.5BRCA2, PALB2
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4BRCA1, BRCA2
4response to ionizing radiationGO:0102128.8RAD54L, BRCA1
5double-strand break repair via homologous recombinationGO:0007248.3RAD54L, PALB2, BRCA1, BRCA2
6DNA repairGO:0062818.2BRCA2, BRCA1, PALB2, RAD54L

Products for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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Sources for Brca2 Hereditary Breast and Ovarian Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet