MCID: BRC055
MIFTS: 37

Brca2 Hereditary Breast and Ovarian Cancer malady

Cancer diseases category

Summaries for Brca2 Hereditary Breast and Ovarian Cancer

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MalaCards: Brca2 Hereditary Breast and Ovarian Cancer, also known as malignant neoplasms, is related to brca1 and brca2 hereditary breast and ovarian cancer and pancreatic cancer. An important gene associated with Brca2 Hereditary Breast and Ovarian Cancer is BRCA2 (breast cancer 2, early onset), and among its related pathways are DNA damage DNA-damage-induced responses and Assembly of the RAD51-ssDNA nucleoprotein complex. The compounds estrogen and resveratrol have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are embryogenesis and normal.

Aliases & Classifications for Brca2 Hereditary Breast and Ovarian Cancer

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Classifications:

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Global: Cancer diseases


Aliases & Descriptions:

brca2 hereditary breast and ovarian cancer 20
malignant neoplasms 60


Related Diseases for Brca2 Hereditary Breast and Ovarian Cancer

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17GeneCards, 18GeneDecks
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Diseases related to Brca2 Hereditary Breast and Ovarian Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 647)
idRelated DiseaseScoreTop Affiliating Genes
1brca1 and brca2 hereditary breast and ovarian cancer31.1BRCA2, BRCA1
2pancreatic cancer30.7BRCA2, AKT1, KRAS
3stomach cancer30.6KRAS, CHEK2, AKT1, PIK3CA, CASP8
4hepatocellular carcinoma30.6BRCA2, CASP8, PIK3CA, AKT1, KRAS, TSG101
5leukemia30.5BRCA1, BRCA2, CASP8, PIK3CA, AKT1, CHEK2
6breast cancer30.5BRCA1, BRCA2, PIK3CA, AKT1, KRAS
7ovarian cancer30.5TSG101, KRAS, PIK3CA, CASP8, BRCA2, BRCA1
8retinoblastoma30.4BRCA1, BRCA2, CASP8, PHB, PIK3CA, RB1CC1
9breast-ovarian cancer, familial, 230.3BRCA2
10fallopian tube cancer30.3BRCA1, BRCA2
11osteosarcoma30.3CHEK2, CASP8
12thyroid cancer30.3PIK3CA, AKT1
13brain cancer30.3RAD51, AKT1, PIK3CA, CASP8
14neuroblastoma30.2AKT1
15hepatocellular carcinoma, somatic30.2CASP8, PIK3CA
16cervical cancer30.2CASP8, PIK3CA, KRAS, TSG101
17prostate cancer30.2XRCC3, CASP8, BRCA2, BRCA1, PHB, PIK3CA
18myeloid leukemia30.1CASP8
19hepatoblastoma30.1NQO2, SLC22A18
20endometrial carcinoma30.1BRCA1, BRCA2, PIK3CA, AKT1, KRAS
21multiple myeloma30.0AKT1
22b-cell chronic lymphocytic leukemia30.0RAD51, CASP8, BRCA2
23bladder carcinoma30.0KRAS, PIK3CA, XRCC3, CASP8, BRCA1
24lung cancer30.0KRAS, CHEK2, PIK3CA, CASP8
25colon cancer30.0CASP8, PIK3CA, AKT1, CHEK2, KRAS
26burkitt's lymphoma30.0BRCA2, CASP8, PIK3CA, AKT1, CHEK2, KRAS
27ductal carcinoma in situ29.8BRCA1, BRCA2
28neurofibromatosis29.8KRAS
29male breast cancer29.8BRCA1, BRCA2
30sarcoma29.7BRCA2, CHEK2, KRAS
31familial colorectal cancer29.7BRCA2, BRCA1
32ovarian cancer, somatic29.7AKT1, PIK3CA
33glioblastoma multiforme29.7CHEK2, AKT1, PIK3CA, CASP8
34medulloblastoma29.7BRCA2, CASP8, PPM1D, PIK3CA, AKT1
35squamous cell carcinoma29.7CASP8, XRCC3, PIK3CA, AKT1, CHEK2, KRAS
36adenocarcinoma29.7BRCA1, BRCA2, CASP8, XRCC3, PIK3CA, AKT1
37tongue cancer10.6
38nasopharynx carcinoma10.6
39lip cancer10.6
40esophageal cancer10.6
41hypopharynx cancer10.5
42oropharynx cancer10.5
43oral cavity cancer10.5
44kaposi's sarcoma10.4
45salivary gland cancer10.4
46hereditary breast ovarian cancer10.4
47male germ cell tumor, somatic10.4
48parathyroid carcinoma10.3
49epiglottis neoplasm10.3
50splenic flexure cancer10.3

Graphical network of the top 20 diseases related to Brca2 Hereditary Breast and Ovarian Cancer:



Diseases related to brca2 hereditary breast and ovarian cancer

Clinical Features for Brca2 Hereditary Breast and Ovarian Cancer

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Drugs & Therapeutics for Brca2 Hereditary Breast and Ovarian Cancer

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Genetic Tests for Brca2 Hereditary Breast and Ovarian Cancer

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20GeneTests
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Genetic tests related to Brca2 Hereditary Breast and Ovarian Cancer:

id Genetic test Affiliating Genes
1 Brca2 Hereditary Breast and Ovarian Cancer20 BRCA2

Anatomical Context for Brca2 Hereditary Breast and Ovarian Cancer

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32MalaCards
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MalaCards organs/tissues related to Brca2 Hereditary Breast and Ovarian Cancer:

32
Breast

Animal Models for Brca2 Hereditary Breast and Ovarian Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Brca2 Hereditary Breast and Ovarian Cancer:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.8BARD1, PALB2, TSG101
2MP:00028738.6BRCA2, RB1CC1, AKT1, BARD1, KRAS, TSG101
3MP:00053798.3BRCA1, BRCA2, CASP8, PPM1D, PIK3CA, AKT1
4MP:00053978.1BRCA1, BRCA2, CASP8, PPM1D, RB1CC1, AKT1
5MP:00053898.1BRCA1, BRCA2, PPM1D, PHB, PIK3CA, AKT1
6MP:00053877.9BRCA1, BRCA2, CASP8, PPM1D, PIK3CA, RB1CC1
7MP:00020067.9TSG101, PPM1D, PIK3CA, AKT1, CHEK2, BARD1
8MP:00053767.7PHB, PPM1D, CASP8, BRCA2, BRCA1, PIK3CA
9MP:00107717.7BRCA1, BRCA2, CASP8, PPM1D, PHB, PIK3CA
10MP:00053787.5BRCA1, BRCA2, CASP8, PPM1D, PHB, PIK3CA
11MP:00053847.0RB1CC1, PIK3CA, PPM1D, CASP8, BRCA2, BRCA1
12MP:00107686.9PIK3CA, PHB, PPM1D, CASP8, BRCA2, BRCA1

Publications for Brca2 Hereditary Breast and Ovarian Cancer

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Genetic Variations for Brca2 Hereditary Breast and Ovarian Cancer

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Expression for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

Search GEO for disease gene expression data for Brca2 Hereditary Breast and Ovarian Cancer.

Pathways for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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12EMD Millipore, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 59Tocris Bioscience, 49PharmGKB, 55SinoBiological, 4Cell Signaling Technology
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Pathways related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CHEK2, BRCA1
2
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10.1RAD51, BRCA2
3
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9.9RAD51, BRCA2, BRCA1
49.9RAD54L, RAD51, BRCA1
59.8RAD51, CHEK2, BRCA1
69.8BRCA1, CHEK2, BARD1
79.8AKT1, PIK3CA
8
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9.7BRCA1, BRCA2, RAD51, PALB2
9
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9.7RAD54L, RAD51, XRCC3, BRCA2
109.7BRCA1, CASP8, AKT1
119.7PPM1D, AKT1, CHEK2
12
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9.7RAD51, BARD1, BRCA2, BRCA1
13
Immune response IFN gamma signaling pathway
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9.6AKT1, PIK3CA, BRCA1
14
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9.5CASP8, PIK3CA, AKT1
15
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9.5CASP8, PIK3CA, AKT1
16
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9.5AKT1, PIK3CA, CASP8
179.5CASP8, PIK3CA, AKT1
18
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9.5PIK3CA, AKT1, KRAS
19
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9.5PIK3CA, AKT1, KRAS
209.5BRCA1, BRCA2, BRIP1, RAD51, PALB2
21
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9.5CHEK2, AKT1, CASP8, BRCA1
22
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9.4BRCA1, BRCA2, CHEK2, BARD1, RAD51
239.4RAD51, BARD1, CHEK2, BRCA2, BRCA1
24
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9.3BRCA1, PIK3CA, AKT1, KRAS
25
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9.3BRCA1, CASP8, PPM1D, CHEK2, RAD51
269.3KRAS, CHEK2, AKT1, PIK3CA
27
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9.2CASP8, PIK3CA, AKT1, KRAS
28
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9.2BRCA1, BRCA2, PIK3CA, AKT1, KRAS
29
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.2BRCA1, BRCA2, BRIP1, CHEK2, BARD1, RAD51
30
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9.1TSG101, AKT1, RB1CC1, BRCA2, BRCA1
31
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9.1BRCA2, PIK3CA, AKT1, RAD51, KRAS
32
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9.0CASP8, PIK3CA, AKT1, CHEK2, KRAS
33
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9.0BRCA1, BRCA2, BRIP1, PPM1D, PHB, CHEK2
34
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8.9BRCA1, CASP8, PIK3CA, AKT1, CHEK2, BARD1
358.8BRCA2, CASP8, PIK3CA, AKT1, RAD51, KRAS
368.2BRCA1, BRCA2, CASP8, PIK3CA, RB1CC1, AKT1
377.9KRAS, BRCA1, BRCA2, CASP8, XRCC3, PHB

Compounds for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7BARD1
2resveratrol44 59 11 2413.6NQO2, BRCA2
3methylmethanesulfonate4410.3BRCA1, BRCA2, RAD51
4aphidicolin4410.2BRCA1, CHEK2, RAD51
5o6-methylguanine4410.2KRAS, RAD51, BRCA2
64-hydroxytamoxifen4410.1AKT1, BRCA2, BRCA1
7hydroxyurea44 49 1112.1BRCA1, BRCA2, CHEK2, RAD51
8melphalan44 1111.1RAD51, XRCC3, CASP8
9oxaliplatin44 49 1112.1KRAS, CASP8, BRCA1
10mevastatin44 28 1112.0CASP8, AKT1
11caffeine44 49 28 2 11 2415.0BRCA1, XRCC3, CHEK2, RAD51
12tamoxifen44 49 28 1113.0AKT1, PIK3CA
1317-(allylamino)-17-demethoxygeldanamycin4410.0CHEK2, AKT1, CASP8
14adpribose4410.0PIK3CA, CASP8, BRCA2, BRCA1
15p0034410.0XRCC3, BRCA2, BRCA1
16indole-3-carbinol449.9BRCA1, BRCA2, CASP8, AKT1
17docetaxel44 49 59 1112.9PIK3CA, CASP8, BRCA2, BRCA1
18polyacrylamide449.9BRCA1, BRCA2, RAD51, KRAS
19nocodazole44 1110.9CHEK2, AKT1, BRCA1
20mitomycin c449.9BRCA1, BRCA2, CASP8, XRCC3, RAD51
21ag 1478449.8AKT1, PIK3CA, CASP8
22lactacystin449.8AKT1, CASP8, BRCA1
23vincristine44 49 1111.8BRCA1, BRCA2, AKT1, TSG101
245fluorouracil449.7BRCA1, CASP8, PIK3CA, KRAS
25quercetin44 59 11 2412.7CASP8, PIK3CA, AKT1, NQO2
26n acetylcysteine449.7CASP8, XRCC3, AKT1, CHEK2
27imatinib44 49 1111.7KRAS, RAD51, PIK3CA, CASP8
28gefitinib44 49 1111.7PIK3CA, AKT1, RAD51, KRAS
29gemcitabine44 49 1111.6BRCA1, CASP8, AKT1, CHEK2, RAD51
30genistein44 28 59 2 11 2414.6BRCA1, BRCA2, PIK3CA, AKT1, CHEK2
31adriamycin449.6CASP8, AKT1, CHEK2, TSG101
32pd-184352449.6KRAS, CASP8
33cycloheximide449.6BRCA1, BRCA2, CASP8, AKT1, RAD51
34doxorubicin44 49 1111.5BRCA1, CASP8, PIK3CA, AKT1, CHEK2
35camptothecin44 59 1111.4RAD51, BRCA1, BRCA2, CASP8, XRCC3, PHB
36atp44 2810.4BRCA1, PHB, PIK3CA, CHEK2, RAD51, RAD54L
37oxygen44 2410.4BRCA1, CASP8, PHB, CHEK2, NQO2, KRAS
38rapamycin449.3PIK3CA, AKT1, CHEK2, KRAS
39ly294002449.2KRAS, AKT1, PIK3CA, CASP8
40wortmannin449.2CASP8, PIK3CA, AKT1, CHEK2, RAD51, KRAS
41testosterone44 59 11 2412.2BRCA1, BRCA2, PIK3CA, AKT1, TSG101
42etoposide44 49 59 1112.2BRCA1, BRCA2, CASP8, PIK3CA, AKT1, CHEK2
43threonine449.2CASP8, PPM1D, PIK3CA, AKT1, CHEK2, RAD51
44paclitaxel44 49 1111.1BRCA1, BRCA2, CASP8, PIK3CA, AKT1, RAD51
45phosphatidylinositol449.1BRCA1, BRCA2, CASP8, PIK3CA, AKT1, CHEK2
46h2o2449.1BRCA1, BRCA2, CASP8, PIK3CA, AKT1, RAD51
47retinoic acid44 2410.0BRCA1, BRCA2, CASP8, PIK3CA, AKT1, CHEK2
48cisplatin44 49 59 1111.7BRCA1, BRCA2, CASP8, XRCC3, PIK3CA, AKT1
49serine448.5BRCA1, CASP8, PPM1D, PIK3CA, AKT1, CHEK2
50tyrosine448.2BRCA1, CASP8, PIK3CA, AKT1, CHEK2, RAD51

GO Terms for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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16Gene Ontology
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Cellular components related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BRCA1-BARD1 complexGO:03143610.1BARD1, BRCA1
2BRCA1-A complexGO:07053110.1BARD1, BRCA1
3nucleoplasmGO:0056548.6BRCA1, BRCA2, PHB, AKT1, CHEK2, RAD51
4nucleusGO:0056347.6BRCA1, BRCA2, BRIP1, CASP8, XRCC3, PPM1D
5cytoplasmGO:0057377.0PHB, XRCC3, CASP8, BRIP1, BRCA2, AKT1

Biological processes related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1protein K6-linked ubiquitinationGO:08502010.2BARD1, BRCA1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.1BRCA2, BRCA1
3inner cell mass cell proliferationGO:00183310.0PALB2, BRCA2
4DNA recombinationGO:00631010.0XRCC3, RAD51, RAD54L
5striated muscle cell differentiationGO:0511469.9KRAS, AKT1
6double-strand break repair via homologous recombinationGO:0007249.8PALB2, RAD54L, RAD51, BRCA2, BRCA1
7positive regulation of protein phosphorylationGO:0019349.6RB1CC1, AKT1, KRAS
8double-strand break repairGO:0063029.6BRCA1, BRCA2, BRIP1, CHEK2, RAD51
9response to DNA damage stimulusGO:0069749.6BRCA1, XRCC3, CHEK2, BARD1, RAD51
10positive regulation of nitric-oxide synthase activityGO:0510009.5KRAS, AKT1
11DNA repairGO:0062819.3BRCA1, BRCA2, XRCC3, BARD1, RAD51, RAD54L

Molecular functions related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:0316258.9BRCA1, CHEK2, SLC22A18, TSG101
2ATP bindingGO:0055248.7RAD54L, RAD51, CHEK2, AKT1, PIK3CA, XRCC3
3protein bindingGO:0055156.2TSG101, BRCA1, BRCA2, BRIP1, CASP8, XRCC3

Products for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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Sources for Brca2 Hereditary Breast and Ovarian Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet