MCID: BRC055
MIFTS: 30

Brca2 Hereditary Breast and Ovarian Cancer malady

Genetic diseases (common), Cancer diseases categories
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Summaries for Brca2 Hereditary Breast and Ovarian Cancer

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MalaCards: Brca2 Hereditary Breast and Ovarian Cancer, also known as malignant neoplasms, is related to brca1 and brca2 hereditary breast and ovarian cancer and ovarian cancer. An important gene associated with Brca2 Hereditary Breast and Ovarian Cancer is BRCA2 (breast cancer 2, early onset), and among its related pathways are Meiosis and Chks in Checkpoint Regulation. The compounds 8-oxoguanine and daidzein have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Aliases & Classifications for Brca2 Hereditary Breast and Ovarian Cancer

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20GeneTests, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases


Aliases & Descriptions:

brca2 hereditary breast and ovarian cancer 20
malignant neoplasms 62


Related Diseases for Brca2 Hereditary Breast and Ovarian Cancer

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Brca2 Hereditary Breast and Ovarian Cancer:



Diseases related to brca2 hereditary breast and ovarian cancer

Symptoms for Brca2 Hereditary Breast and Ovarian Cancer

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Drugs & Therapeutics for Brca2 Hereditary Breast and Ovarian Cancer

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Brca2 Hereditary Breast and Ovarian Cancer

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20GeneTests
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Genetic tests related to Brca2 Hereditary Breast and Ovarian Cancer:

id Genetic test Affiliating Genes
1 Brca2 Hereditary Breast and Ovarian Cancer20 BRCA2

Anatomical Context for Brca2 Hereditary Breast and Ovarian Cancer

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33MalaCards
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MalaCards organs/tissues related to Brca2 Hereditary Breast and Ovarian Cancer:

33
Breast

Animal Models for Brca2 Hereditary Breast and Ovarian Cancer or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Brca2 Hereditary Breast and Ovarian Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.0BRCA2, BRCA1, PALB2
2MP:00020068.5NQO2, BRCA2, BRCA1, PALB2
3MP:00107718.5NQO2, BRCA2, BRCA1, PALB2
4MP:00053978.1RAD54L, BRCA1, BRCA2, NQO2
5MP:00053768.1RAD54L, BRCA1, NQO2, BRCA2
6MP:00053878.0RAD54L, BRCA1, BRCA2, NQO2
7MP:00053847.9PALB2, BRCA1, BRCA2, RAD54L

Publications for Brca2 Hereditary Breast and Ovarian Cancer

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52PubMed
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Articles related to Brca2 Hereditary Breast and Ovarian Cancer:

idTitleAuthorsYear
1
BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer (20301425)
1993

Variations for Brca2 Hereditary Breast and Ovarian Cancer

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Expression for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

Search GEO for disease gene expression data for Brca2 Hereditary Breast and Ovarian Cancer.

Pathways for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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50PathCards, 12EMD Millipore, 55Reactome, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters
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Pathways related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5BRCA2, BRCA1
2
Show member pathways
9.5BRCA1, BRCA2
3
Show member pathways
Signaling Pathways in Glioblastoma38
9.5BRCA1, BRCA2
49.5BRCA1, BRCA2
5
Show member pathways
9.5BRCA2, BRCA1
69.5BRCA1, BRCA2
7
Show member pathways
9.5BRCA2, BRCA1
8
Show member pathways
Homologous recombination38
9.2BRCA2, RAD54L
99.1RAD54L, BRCA1
109.0BRCA1, PALB2, BRCA2
11
Show member pathways
9.0BRCA1, BRCA2, PALB2
12
Show member pathways
9.0BRCA2, PALB2, BRCA1
138.7BRCA1, BRCA2, RAD54L

Compounds for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 3BitterDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
18-oxoguanine459.9BRCA2, BRCA1
2daidzein459.8BRCA2, BRCA1
3lycopene45 2410.8BRCA1, BRCA2
4indole-3-carbinol459.8BRCA1, BRCA2
5methylmethanesulfonate459.8BRCA2, BRCA1
64-hydroxytamoxifen459.8BRCA1, BRCA2
7bleomycin45 1110.8BRCA2, BRCA1
8adpribose459.8BRCA1, BRCA2
9hydroxyurea45 51 1111.8BRCA2, BRCA1
10mitomycin c459.8BRCA1, BRCA2
11p003459.7BRCA1, BRCA2
12vincristine45 51 1111.7BRCA2, BRCA1
13p002459.7BRCA1, BRCA2
14adriamycin459.7BRCA1, BRCA2
15benzo(a)pyrene459.7BRCA1, NQO2
16gold459.6BRCA2, BRCA1
17chloroquine45 3 51 29 1113.6BRCA1, NQO2
18camptothecin45 61 1111.6BRCA1, BRCA2
19docetaxel45 51 61 1112.6BRCA1, BRCA2
20polyacrylamide459.5BRCA1, BRCA2
21folate459.4BRCA1, BRCA2
22cyclophosphamide45 51 1111.3NQO2, BRCA1
23resveratrol45 61 24 1112.2BRCA1, BRCA2, NQO2
24methotrexate51 45 1111.2BRCA1, BRCA2

GO Terms for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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16Gene Ontology
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Cellular components related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.0PALB2, BRCA2, BRCA1
2nucleolusGO:0057308.0NQO2, BRCA2, PALB2, RAD54L
3nucleusGO:0056347.2RAD54L, NQO2, BRCA2, BRCA1, PALB2

Biological processes related to Brca2 Hereditary Breast and Ovarian Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-strand break repairGO:0063029.5BRCA1, BRCA2
2inner cell mass cell proliferationGO:0018339.5BRCA2, PALB2
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4BRCA1, BRCA2
4response to ionizing radiationGO:0102128.8RAD54L, BRCA1
5double-strand break repair via homologous recombinationGO:0007248.3RAD54L, PALB2, BRCA1, BRCA2
6DNA repairGO:0062818.2BRCA2, BRCA1, PALB2, RAD54L

Products for genes affiliated with Brca2 Hereditary Breast and Ovarian Cancer

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Sources for Brca2 Hereditary Breast and Ovarian Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet