MCID: BRS044
MIFTS: 45

Breast Adenocarcinoma malady

Reproductive diseases, Cancer diseases, Rare diseases categories

Summaries for Breast Adenocarcinoma

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Disease Ontology:10 A breast carcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast.

MalaCards based summary: Breast Adenocarcinoma, also known as mammary adenocarcinoma, is related to adenocarcinoma and breast cancer. An important gene associated with Breast Adenocarcinoma is AKT1 (v-akt murine thymoma viral oncogene homolog 1), and among its related pathways are a6b1 and a6b4 Integrin signaling and G protein signaling Cross talk between Ras family GTPases. The compounds ptdins(3)p and everolimus have been mentioned in the context of this disorder. Affiliated tissues include breast, colon and brain, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Breast Adenocarcinoma

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Breast Adenocarcinoma, Aliases & Descriptions:

Name: Breast Adenocarcinoma 10 62
 
Mammary Adenocarcinoma 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Reproductive diseases


External Ids:

Disease Ontology10 DOID:3458
NCIt40 C5214

Related Diseases for Breast Adenocarcinoma

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Graphical network of the top 20 diseases related to Breast Adenocarcinoma:



Diseases related to breast adenocarcinoma

Symptoms for Breast Adenocarcinoma

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Drugs & Therapeutics for Breast Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Breast Adenocarcinoma

Search NIH Clinical Center for Breast Adenocarcinoma

Genetic Tests for Breast Adenocarcinoma

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Anatomical Context for Breast Adenocarcinoma

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MalaCards organs/tissues related to Breast Adenocarcinoma:

33
Breast, Colon, Brain, Liver, Bone, Lymph node, Prostate, T cells, Endothelial, Whole blood, Spinal cord, Lung, Pancreas, Skin, Testes, Monocytes, B cells

Animal Models for Breast Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Breast Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.4CTSK, NPPC, NPR1, AKT1, KCNA3, NQO1

Publications for Breast Adenocarcinoma

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Articles related to Breast Adenocarcinoma:

(show top 50)    (show all 258)
idTitleAuthorsYear
1
In vitro evaluation of curcumin effects on breast adenocarcinoma 2D and 3D cell cultures. (25826489)
2015
2
Epithelial cell adhesion molecule aptamer conjugated PEG-PLGA nanopolymersomes for targeted delivery of doxorubicin to human breast adenocarcinoma cell line in vitro. (25529433)
2015
3
Inhibition of the transient receptor potential melastatin-2 channel causes increased DNA damage and decreased proliferation in breast adenocarcinoma cells. (25760245)
2015
4
Multiple molecular forms of adaptor protein Ruk/CIN85 specifically associate with different subcellular compartments in human breast adenocarcinoma MCF-7 cells. (25816594)
2014
5
Lipid Peroxidation and Altered Anti-oxidant Status in Breast Adenocarcinoma Patients. (25050522)
2014
6
D-Glucose-Induced Cytotoxic, Genotoxic, and Apoptotic Effects on Human Breast Adenocarcinoma (MCF-7) Cells. (25506409)
2014
7
XIAP inhibitor and antiestrogen embelin abrogates metastasis and augments apoptosis in estrogen receptor positive human breast adenocarcinoma cell line MCF-7. (24390234)
2014
8
Anticancer Activity of Cobra Venom Polypeptide, Cytotoxin-II, against Human Breast Adenocarcinoma Cell Line (MCF-7) via the Induction of Apoptosis. (25548578)
2014
9
Gemifloxacin inhibits migration and invasion and induces mesenchymal-epithelial transition in human breast adenocarcinoma cells. (24005829)
2014
10
The in vitro influences of epidermal growth factor and heregulin-I^1 on the efficacy of trastuzumab used in Her-2 positive breast adenocarcinoma. (24119761)
2013
11
Induction of apoptosis in human breast adenocarcinoma cells MCF-7 by monapurpyridine A, a new azaphilone derivative from Monascus purpureus NTU 568. (22237681)
2012
12
Treatment of breast adenocarcinoma metastasis to the neck: dedifferentiation of the tumor as suggested by hormone markers. (22038868)
2012
13
4-Shogaol, an active constituent of dietary ginger, inhibits metastasis of MDA-MB-231 human breast adenocarcinoma cells by decreasing the repression of NF-I_B/Snail on RKIP. (22224671)
2012
14
Regulation of CD1, Ki-67, PCNA mRNA expression, and Akt activation in estrogen-responsive human breast adenocarcinoma cell line, MCF-7 cells, by griffonianone C, an isoflavone derived from Millettia griffoniana. (21284537)
2011
15
The influence of phenothiazine derivatives on doxorubicin treatment in sensitive and resistant human breast adenocarcinoma cells. (22264721)
2011
16
Synthesis and anticancer effects of some novel pyrazolo[3,4-d]pyrimidine derivatives by generating reactive oxygen species in human breast adenocarcinoma cells. (21315495)
2011
17
A proposed anatomical explanation for perineural spread of breast adenocarcinoma to the brachial plexus. (21154646)
2011
18
Modulation of DNA methylation levels sensitizes doxorubicin-resistant breast adenocarcinoma cells to radiation-induced apoptosis. (20034463)
2010
19
Primary human breast adenocarcinoma: imaging and histologic correlates of intrinsic susceptibility-weighted MR imaging before and during chemotherapy. (20858850)
2010
20
Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate. (20924379)
2010
21
Effects of Leuzea carthamoides on human breast adenocarcinoma MCF-7 cells determined by gene expression profiling and functional assays. (18975255)
2008
22
Selenocystine induces S-phase arrest and apoptosis in human breast adenocarcinoma MCF-7 cells by modulating ERK and Akt phosphorylation. (18959417)
2008
23
Human breast adenocarcinoma (MDA-231) and human lung squamous cell carcinoma (Hara) do not have the ability to cause bone resorption by themselves during the establishment of bone metastasis. (18301992)
2008
24
Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets. (17363502)
2007
25
Silencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4T1 breast adenocarcinoma cell. (16340246)
2006
26
Spinal cord compression in a patient with multiple hereditary exostoses caused by breast adenocarcinoma metastatic to osteochondromas of the spine: case report. (17108823)
2006
27
Distant metastasis from subcutaneously grown E0771 medullary breast adenocarcinoma. (16312045)
2005
28
Calcified metastatic mediastinal lymph nodes from mucinous breast adenocarcinoma. (14566424)
2004
29
Effect of pH on uptake and photodynamic action of chlorin p6 on human colon and breast adenocarcinoma cell lines. (14872242)
2004
30
Neuroendocrine differentiation and prognosis in breast adenocarcinoma. (11895486)
2002
31
Ras and Rho protein induction of motility and invasion in T47D breast adenocarcinoma cells. (11400341)
2001
32
P1, a high mobility group-like protein is depressed in human breast adenocarcinoma. (11544097)
2001
33
17beta-estradiol inhibits forskolin-induced vascular endothelial growth factor promoter in MCF-7 breast adenocarcinoma cells. (11717004)
2001
34
Metastatic breast adenocarcinoma diagnosed by aspiration of a pulmonary artery embolism. (10740622)
2000
35
Expression of transforming growth factor-beta receptor type II and tumorigenicity in human breast adenocarcinoma MCF-7 cells. (9648930)
1998
36
Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells. (10023317)
1998
37
Characterization of human breast adenocarcinoma SK-BR-3 cells resistant to doxorubicin. (9372856)
1997
38
Involvement of p21 in mitotic exit after paclitaxel treatment in MCF-7 breast adenocarcinoma cell line. (9419978)
1997
39
Radioimmunoscintigraphy in patients with breast adenocarcinoma using technetium-99m labelled monoclonal antibody 170H.82: report of a phase II study. (9096088)
1997
40
Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. (7671262)
1995
41
Fine-needle aspiration cytology in locally advanced breast adenocarcinoma: a case with complete response to preoperative chemotherapy in association with granulomatous inflammatory reaction. (7924810)
1994
42
Identification of the class-3 aldehyde dehydrogenases present in human MCF-7/0 breast adenocarcinoma cells and normal human breast tissue. (8068047)
1994
43
Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts. (8217606)
1993
44
Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells. (1709586)
1991
45
Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7. (1883381)
1991
46
Erythrocytosis caused by an erythropoietin-producing breast adenocarcinoma. (2161586)
1990
47
Growth modulation effects of synthetic steroids on rat prostatic adenocarcinoma and human breast adenocarcinoma cells in vitro. (2357267)
1990
48
Effects of three new folate antagonists on human breast adenocarcinoma cells in vitro and on immune responses in vivo. (6692721)
1984
49
A retrovirus-producing transformed mouse cell line derived from a human breast adenocarcinoma transplanted in a nude mouse. (6309650)
1983
50
Metastatic breast adenocarcinoma to Brenner tumors. (7372198)
1980

Variations for Breast Adenocarcinoma

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Clinvar genetic disease variations for Breast Adenocarcinoma:

7
id Gene Variation Type Significance SNP ID Assembly Location
1PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
2PIK3CANM_006218.2(PIK3CA): c.3140A> T (p.His1047Leu)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
3PIK3CANM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)single nucleotide variantPathogenicrs104886003GRCh37Chr 3, 178936091: 178936091
4AKT1NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)single nucleotide variantPathogenicrs121434592GRCh37Chr 14, 105246551: 105246551

Expression for genes affiliated with Breast Adenocarcinoma

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Search GEO for disease gene expression data for Breast Adenocarcinoma.

Pathways for genes affiliated with Breast Adenocarcinoma

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Pathways related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0PIK3CA, AKT1
210.0PIK3CA, AKT1
310.0PIK3CA, AKT1
410.0PIK3CA, AKT1
5
Show member pathways
Insulin Pathway38
10.0PIK3CA, AKT1
610.0PIK3CA, AKT1
710.0PIK3CA, AKT1
810.0AKT1, PIK3CA
910.0AKT1, PIK3CA
1010.0AKT1, PIK3CA
1110.0AKT1, PIK3CA
1210.0AKT1, PIK3CA
1310.0AKT1, PIK3CA
1410.0AKT1, PIK3CA
15
Show member pathways
10.0AKT1, PIK3CA
16
Show member pathways
Angiogenesis38
10.0AKT1, PIK3CA
1710.0AKT1, PIK3CA
1810.0AKT1, PIK3CA
1910.0AKT1, PIK3CA
209.9NQO1, PIK3CA
219.7AKT1, AREGB
229.7PIK3CA, AKT1, CTSK
23
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.7CTSK, AKT1, PIK3CA
24
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.5AREGB, AKT1, PIK3CA
25
Show member pathways
AhR pathway38
9.5ALDH3A1, NQO1

Compounds for genes affiliated with Breast Adenocarcinoma

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Compounds related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1ptdins(3)p4510.2AKT1, PIK3CA
2everolimus45 51 1312.2AKT1, PIK3CA
3urodilatin4510.1NPPC, NPR1
48-bromo cgmp4510.1NPPC, NPR1
5l-nmma4510.0PIK3CA, AKT1, NPPC
6bcnu4510.0AKT1, NQO1
7quercetin45 61 26 1312.9PIK3CA, NQO1, AKT1
8arsenite45 2610.8PIK3CA, NQO1, AKT1
9mafosfamide459.8NQO1, ALDH3A1
1017-(allylamino)-17-demethoxygeldanamycin459.8AKT1, NQO1
11agar459.7AKT1, NQO1, PIK3CA
12indole-3-carbinol459.6AKT1, NQO1
13tcdd459.5ALDH3A1, NQO1
14dexamethasone45 51 30 1312.3PIK3CA, NQO1, AKT1, NPPC
15nadph45 2610.3ALDH3A1, AKT1, NQO1, PIK3CA
16testosterone45 61 26 1312.1AREGB, NPPC, AKT1, NQO1, PIK3CA
17estrogen459.0PIK3CA, NQO1, WISP2, AKT1, NPR1
18retinoic acid45 2610.0CTSK, NPPC, ALDH3A1, AKT1, PIK3CA
19cysteine458.7NQO1, WISP2, AKT1, NPR1, NPPC, CTSK
20serine458.2CTSK, PIK3CA, C1RL, NQO1, AKT1, NPR1

GO Terms for genes affiliated with Breast Adenocarcinoma

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Cellular components related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.1AREGB, CTSK, NPPC, ALDH3A1, WISP2, IGHA1

Biological processes related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:000618210.1NPPC, NPR1
2positive regulation of cGMP biosynthetic processGO:003082810.0NPPC, NPR1
3receptor guanylyl cyclase signaling pathwayGO:000716810.0NPPC, NPR1
4nitric oxide biosynthetic processGO:000680910.0AKT1, NQO1
5regulation of blood vessel sizeGO:00508809.9NPR1, NPPC
6regulation of multicellular organism growthGO:00400149.8NPPC, PIK3CA
7protein kinase B signalingGO:00434919.7PIK3CA, AKT1
8epidermal growth factor receptor signaling pathwayGO:00071739.5AREGB, AKT1, PIK3CA
9agingGO:00075689.4NQO1, AKT1, ALDH3A1
10innate immune responseGO:00450878.9CTSK, AKT1, C1RL, PIK3CA

Molecular functions related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:001630110.0AKT1, PIK3CA

Products for genes affiliated with Breast Adenocarcinoma

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Sources for Breast Adenocarcinoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet