MCID: BRS044
MIFTS: 45

Breast Adenocarcinoma malady

Summaries for Breast Adenocarcinoma

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 An adenocarcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast.

MalaCards: Breast Adenocarcinoma, also known as mammary adenocarcinoma, is related to adenocarcinoma and colorectal cancer. An important gene associated with Breast Adenocarcinoma is CST9 (cystatin 9 (testatin)), and among its related pathways is PAK Pathway. The compounds estrogen and 8-bromo cgmp have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and brain, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Classifications for Breast Adenocarcinoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt
See all sources

Aliases & Descriptions:

breast adenocarcinoma 8 61
mammary adenocarcinoma 8


External Ids:

Disease Ontology8 DOID:3458
NCIt40 C5214

Related Diseases for Breast Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Breast Adenocarcinoma family:

rare adenocarcinoma of the breast

Diseases related to Breast Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.7ALDH3A1, CCNA2, CA9, NPR1, NPPC, MDK
2colorectal cancer29.9CA9, AREGB, AREG, PTPN6
3squamous cell carcinoma10.1
4vulva adenocarcinoma10.1
5somatostatin analog10.1
6adenoma10.0
7colon cancer10.0AREG, CCNA2
8cutaneous t cell lymphoma10.0PTPN6, CXCL10, CXCR3
9colon adenocarcinoma10.0CCNA2, NPR1, NPPC, AREG
10sarcoma10.0CA9, CCNA2
11ovarian cancer10.0CCNA2, CA9, AREG, PTPN6
12prostate cancer10.0CCNA2, CA9, CTSK, AREG, CXCL10, PTPN6
13cervical cancer10.0AREG, CA9, CCNA2
14bladder carcinoma10.0CA9, AREG, CXCL10, SPAM1
15breast cancer10.0MDK, CTSK, WISP2, CA9, CCNA2, AREGB
16acromesomelic dysplasia10.0NPPC
17hepatocellular carcinoma10.0CCNA2, MDK, AREG, ALDH3A1
18rheumatoid arthritis10.0KCNN4, CTSK, AREG, CXCR3, CXCL10
19pancreatic cancer10.0AREG, CA9, CCNA2
20myeloma10.0AREG, CTSK, CCNA2
21asthma10.0CCNA2, NPPC, AREG, CXCR3, CXCL10
22allergic contact dermatitis10.0CXCL10, CXCR3
23pulmonary disease, chronic obstructive10.0AREG, CXCR3, CXCL10
24pulmonary fibrosis10.0CXCR3, CTSK
25periapical granuloma10.0CXCR3
26kidney cancer10.0CA9, NPR1, NPPC, CXCR3
27burkitt's lymphoma10.0PTPN6, CXCR3, CCNA2
28lung cancer10.0CCNA2, CA9, CTSK, AREG, CXCR3
29male breast cancer10.0
30bone carcinoma10.0
31breast fibrosarcoma10.0
32hereditary multiple exostoses10.0
33malignant breast melanoma10.0
34signet ring cell adenocarcinoma10.0
35breast signet ring cell adenocarcinoma10.0
36kallmann syndrome10.0
37mucinous adenocarcinoma10.0
38cauda equina syndrome10.0
39breast lymphoma10.0
40adenocarcinoma in situ10.0
41apocrine adenocarcinoma10.0
42t-cell leukemia10.0
43hereditary multiple osteochondromas10.0
44osteochondroma10.0
45hypoxia10.0
46leukemia/lymphoma, t-cell10.0
47erythrocytosis10.0

Graphical network of the top 20 diseases related to Breast Adenocarcinoma:



Diseases related to breast adenocarcinoma

Clinical Features for Breast Adenocarcinoma

Drugs & Therapeutics for Breast Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Breast Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Breast Adenocarcinoma

Search NIH Clinical Center for Breast Adenocarcinoma

Search CenterWatch for Breast Adenocarcinoma

Genetic Tests for Breast Adenocarcinoma

Anatomical Context for Breast Adenocarcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Breast Adenocarcinoma:

33
Whole blood, Lymph node, Brain, Spinal cord, Colon, Liver, Lung, Pancreas, Thyroid, Salivary gland, Breast, Skin, Ovary, Placenta, Prostate, Cervix, Monocytes, T cells, B cells, Endothelial

Animal Models for Breast Adenocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Breast Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.4CA9, NPR1, NPPC, CTSK, AREG, PTPN6
2MP:000538710.1PTPN6, KCNN4, CCNA2, NPR1, CTSK, MDK

Publications for Breast Adenocarcinoma

Sources:
51PubMed
See all sources

Articles related to Breast Adenocarcinoma:

(show top 50)    (show all 302)
idTitleAuthorsYear
1
The in vitro influences of epidermal growth factor and heregulin-I^1 on the efficacy of trastuzumab used in Her-2 positive breast adenocarcinoma. (24119761)
2013
2
Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma. (22864623)
2013
3
Adenocarcinoma of the right breast in a man with intellectual disability. (23956899)
2013
4
Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by I+-tomatine through activating PKCI+/ERK/NF-I_B-dependent MMP-2/MMP-9 expressions. (23114726)
2013
5
In vitro changes in mitochondrial potential, aggresome formation and caspase activity by a novel 17-I^-estradiol analogue in breast adenocarcinoma cells. (23307628)
2013
6
Treatment of breast adenocarcinoma metastasis to the neck: dedifferentiation of the tumor as suggested by hormone markers. (22038868)
2012
7
4-Shogaol, an active constituent of dietary ginger, inhibits metastasis of MDA-MB-231 human breast adenocarcinoma cells by decreasing the repression of NF-I_B/Snail on RKIP. (22224671)
2012
8
A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma. (22954488)
2012
9
The influence of phenothiazine derivatives on doxorubicin treatment in sensitive and resistant human breast adenocarcinoma cells. (22264721)
2011
10
Effect of Trans-resveratrol on Rotenone-induced Cytotoxicity in Human Breast Adenocarcinoma Cells. (21976814)
2011
11
Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway. (20626003)
2011
12
Modulation of DNA methylation levels sensitizes doxorubicin-resistant breast adenocarcinoma cells to radiation-induced apoptosis. (20034463)
2010
13
Metastatic prostatic adenocarcinoma mimicking inflammatory breast carcinoma: a case report. (20133250)
2010
14
Photo-activated pheophorbide-a, an active component of Scutellaria barbata, enhances apoptosis via the suppression of ERK-mediated autophagy in the estrogen receptor-negative human breast adenocarcinoma cells MDA-MB-231. (20558270)
2010
15
Interactions of doxycycline with chemotherapeutic agents in human breast adenocarcinoma MDA-MB-231 cells. (19209028)
2009
16
DNA methylation of K(v)1.3 potassium channel gene promoter is associated with poorly differentiated breast adenocarcinoma. (19590190)
2009
17
Selenocystine induces S-phase arrest and apoptosis in human breast adenocarcinoma MCF-7 cells by modulating ERK and Akt phosphorylation. (18959417)
2008
18
Human breast adenocarcinoma (MDA-231) and human lung squamous cell carcinoma (Hara) do not have the ability to cause bone resorption by themselves during the establishment of bone metastasis. (18301992)
2008
19
Design and QSAR study of analogs of alpha-tocopherol with enhanced antiproliferative activity against human breast adenocarcinoma cells. (17616411)
2008
20
Breast adenocarcinoma mimicking temporomandibular disorders: a case report. (18633475)
2008
21
Hyperthermia engages the intrinsic apoptotic pathway by enhancing upstream caspase activation to overcome apoptotic resistance in MCF-7 breast adenocarcinoma cells. (16440323)
2006
22
EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice. (16318410)
2006
23
The influence of polysomy 17 on HER2 gene and protein expression in adenocarcinoma of the breast: a fluorescent in situ hybridization, immunohistochemical, and isotopic mRNA in situ hybridization study. (16096413)
2005
24
Correlation of tissue lipid peroxidation and antioxidants with clinical stage and menopausal status in patients with adenocarcinoma of the breast. (15642278)
2005
25
Is detection of endocrine cells in breast adenocarcinoma of diagnostic and clinical significance? (11895485)
2002
26
Induction of apoptosis by iron depletion in the human breast cancer MCF-7 cell line and the 13762NF rat mammary adenocarcinoma in vivo. (12529982)
2002
27
17beta-estradiol inhibits forskolin-induced vascular endothelial growth factor promoter in MCF-7 breast adenocarcinoma cells. (11717004)
2001
28
Prostatic adenocarcinoma metastatic to the breasts: report of a case with diagnosis by fine needle aspiration biopsy. (10754179)
2000
29
Interaction of hyperthermia with Taxol in human MCF-7 breast adenocarcinoma cells. (10365690)
1999
30
Epidermal growth factor stimulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression via the ErbB-2 pathway in human breast adenocarcinoma cells. (10403829)
1999
31
Antitumoral effects of squamocin on parental and multidrug resistant MCF7 (human breast adenocarcinoma) cell lines. (10462079)
1999
32
Intracellular distribution of tamoxifen in resistant human breast adenocarcinoma cells using tamoxifen-eosin association. (9879935)
1998
33
Analysis of human breast adenocarcinoma MCF7 resistance to tumor necrosis factor-induced cell death. Lack of correlation between JNK activation and ceramide pathway. (9786905)
1998
34
Induction of membrane-type matrix metalloproteinase 1 (MT1-MMP) expression in human fibroblasts by breast adenocarcinoma cells. (9062392)
1997
35
Has radiation therapy any role in signet-ring cell breast adenocarcinoma? (9291826)
1997
36
Adenocarcinoma of the breast metastatic to benign ovarian fibroma. (8812542)
1996
37
Co-culture of human breast adenocarcinoma MCF-7 cells and human dermal fibroblasts enhances the production of matrix metalloproteinases 1, 2 and 3 in fibroblasts. (7734296)
1995
38
Fine-needle aspiration cytology in locally advanced breast adenocarcinoma: a case with complete response to preoperative chemotherapy in association with granulomatous inflammatory reaction. (7924810)
1994
39
Identification of a methylcholanthrene-induced aldehyde dehydrogenase in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance. (8174125)
1994
40
Effect of epidermal growth factor in HLA class I and class II transcription and protein expression in human breast adenocarcinoma cell lines. (1637682)
1992
41
Expression of c-erbB-2 in in situ and in adjacent invasive ductal adenocarcinomas of the female breast. (1352687)
1992
42
Basement membrane components (matrigel) promote the tumorigenicity of human breast adenocarcinoma MCF7 cells and provide an in vivo model to assess the responsiveness of cells to estrogen. (1562280)
1992
43
The use of immunohistochemistry in metastatic prostatic adenocarcinoma to the breast. (1706305)
1991
44
Erythrocytosis caused by an erythropoietin-producing breast adenocarcinoma. (2161586)
1990
45
Is DNA ploidy an independent prognostic indicator in infiltrative node-negative breast adenocarcinoma? (2311069)
1990
46
C-band polymorphisms in lymphocytes of patients with ovarian or breast adenocarcinoma. (3475166)
1987
47
Polymorphism of Ag-stained nucleolus organizer regions in lymphocytes of patients with ovarian or breast adenocarcinoma. (2580773)
1985
48
Metastatic breast adenocarcinoma of the mandibular condyle: report of case. (6246229)
1980
49
Increased survival in mice with C3H breast adenocarcinoma after tumor excision and vitamin A supplementation. (401125)
1978
50
Anti-heparin activity of a macroglobulin from a patient with breast adenocarcinoma. (808935)
1975

Genetic Variations for Breast Adenocarcinoma

Expression for genes affiliated with Breast Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Breast Adenocarcinoma

Search GEO for disease gene expression data for Breast Adenocarcinoma.

Pathways for genes affiliated with Breast Adenocarcinoma

Sources:
52QIAGEN
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Pathways related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4PTPN6, CXCL10, CXCR3, AREG, MDK

Compounds for genes affiliated with Breast Adenocarcinoma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8WISP2
28-bromo cgmp4510.8CCNA2, NPR1, NPPC
3thymidine45 2411.8PTPN6, KCNN4, CCNA2, NPPC, AREG, CXCR3
4forskolin45 50 1112.8CCNA2, NPR1, NPPC, AREG, CXCL10
5retinoic acid45 2411.8CCNA2, NPPC, CTSK, MDK, AREG, CXCL10
6heparan sulfate45 2411.8MDK, AREG, CXCR3, CXCL10
7tetraethylammonium45 29 1112.8KCNN4, KCNA3, NPPC
8cl-4as-16010.8AREG, AREGB
9progesterone45 60 29 11 2414.8CCNA2, CA9, WISP2, AREG, CXCR3, CXCL10
10serine4510.8C1RL, CCNA2, NPR1, NPPC, CTSK, AREG
11nitric oxide45 11 2412.8CCNA2, NPR1, NPPC, CXCR3, CXCL10, PTPN6
12calcium45 50 11 2413.8KCNN4, CCNA2, CA9, NPPC, CTSK, AREG
13vegf4510.8CCNA2, CA9, AREG, CXCR3, CXCL10, PTPN6
14chloride4510.8KCNN4, CA9, NPPC, CTSK
15urodilatin4510.7NPPC, NPR1
16iudr4510.7CA9, CCNA2
17tyrosine4510.7CCNA2, CA9, NPPC, CTSK, AREG, CXCR3
18lipid4510.7CCNA2, NPPC, MDK, CXCL10, PTPN6, SPAM1
19heparin45 29 11 2413.7WISP2, AREG, CXCR3
20iberiotoxin45 60 2912.7NPPC, KCNN4
21nilutamide45 60 29 1113.7AREG, AREGB
22mitomycin c4510.6CA9, AREG, ALDH3A1
23histamine45 29 2412.6CXCL10, CXCR3, NPPC, KCNN4
24charybdotoxin45 2911.6KCNA3, KCNN4
25glycosaminoglycan4510.5AREG, CXCL10, SPAM1
26sodium nitroprusside4510.5CXCR3, NPPC, NPR1
27genistein45 29 60 2 11 2415.5PTPN6, CXCL10, NPPC, CCNA2
28phorbol4510.4PTPN6, NPPC, CCNA2
29dexamethasone45 50 29 1113.2CCNA2, NPPC, AREG

GO Terms for genes affiliated with Breast Adenocarcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4CXCL10, AREGB, CTSK, NPPC, WISP2, C1RL

Biological processes related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cGMP biosynthetic processGO:03082810.5NPPC, NPR1
2regulation of blood vessel sizeGO:05088010.5NPPC, NPR1
3cGMP biosynthetic processGO:00618210.4NPPC, NPR1
4receptor guanylyl cyclase signaling pathwayGO:00716810.2NPPC, NPR1

Products for genes affiliated with Breast Adenocarcinoma

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  • Antibodies

Sources for Breast Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet