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MCID: BRS044
MIFTS: 46

Breast Adenocarcinoma malady
102 genes, 22 tissues, 65 related diseases, clinical trials.

Summaries for Breast Adenocarcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An adenocarcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast.

MalaCards: Breast Adenocarcinoma, also known as mammary adenocarcinoma, is related to adenocarcinoma and breast cancer. An important gene associated with Breast Adenocarcinoma is CST9 (cystatin 9 (testatin)), and among its related pathways is PAK Pathway. The compounds estrogen and 8-bromo cgmp have been mentioned in the context of this disorder. Affiliated tissues include breast, colon and lung, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Classifications for Breast Adenocarcinoma

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8Disease Ontology, 60UMLS, 39NCIt
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Aliases & Descriptions:

breast adenocarcinoma 8 60
mammary adenocarcinoma 8


External Ids:

Disease Ontology8 DOID:3458
NCIt39 C5214

Related Diseases for Breast Adenocarcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Breast Adenocarcinoma family:

Rare Adenocarcinoma of the Breast

Diseases related to Breast Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.7ALDH3A1, CCNA2, CA9, NPR1, NPPC, MDK
2breast cancer30.4MDK, CTSK, WISP2, CA9, CCNA2, AREGB
3colon adenocarcinoma30.2CCNA2, NPR1, NPPC, AREG
4sarcoma30.2CA9, CCNA2
5colorectal cancer29.9CA9, AREGB, AREG, PTPN6
6prostate cancer29.9CCNA2, CA9, CTSK, AREG, CXCL10, PTPN6
7cervical cancer29.9AREG, CA9, CCNA2
8breast disease10.2
9breast sarcoma10.2
10mucinous adenocarcinoma10.1
11breast squamous cell carcinoma10.1
12cervical adenocarcinoma10.1
13cervicitis10.1
14leukemia10.1
15prostate adenocarcinoma10.1
16prostatitis10.1
17squamous cell carcinoma10.1
18vulva adenocarcinoma10.1
19adenocarcinoma in situ10.0
20adenoma10.0
21pituitary adenoma10.0
22colon cancer10.0AREG, CCNA2
23cutaneous t cell lymphoma10.0PTPN6, CXCL10, CXCR3
24ovarian cancer10.0CCNA2, CA9, AREG, PTPN6
25bladder carcinoma10.0CA9, AREG, CXCL10, SPAM1
26acromesomelic dysplasia10.0NPPC
27hepatocellular carcinoma10.0CCNA2, MDK, AREG, ALDH3A1
28rheumatoid arthritis10.0KCNN4, CTSK, AREG, CXCR3, CXCL10
29pancreatic cancer10.0AREG, CA9, CCNA2
30myeloma10.0AREG, CTSK, CCNA2
31asthma10.0CCNA2, NPPC, AREG, CXCR3, CXCL10
32allergic contact dermatitis10.0CXCL10, CXCR3
33pulmonary disease, chronic obstructive10.0AREG, CXCR3, CXCL10
34pulmonary fibrosis10.0CXCR3, CTSK
35periapical granuloma10.0CXCR3
36kidney cancer10.0CA9, NPR1, NPPC, CXCR3
37burkitt's lymphoma10.0PTPN6, CXCR3, CCNA2
38lung cancer10.0CCNA2, CA9, CTSK, AREG, CXCR3
39male breast cancer9.9
40bone carcinoma9.9
41breast fibrosarcoma9.9
42hereditary multiple exostoses9.9
43malignant breast melanoma9.9
44signet ring cell adenocarcinoma9.9
45breast signet ring cell adenocarcinoma9.9
46cauda equina syndrome9.9
47breast lymphoma9.9
48apocrine adenocarcinoma9.9
49breast papillomatosis9.9
50cervical squamous cell carcinoma9.9

Graphical network of the top 20 diseases related to Breast Adenocarcinoma:



Diseases related to breast adenocarcinoma

Clinical Features for Breast Adenocarcinoma

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Drugs & Therapeutics for Breast Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Breast Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Breast Adenocarcinoma

Search NIH Clinical Center for Breast Adenocarcinoma

Search CenterWatch for Breast Adenocarcinoma

Genetic Tests for Breast Adenocarcinoma

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Anatomical Context for Breast Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Breast Adenocarcinoma:

32
Breast, Colon, Lung, Prostate, Liver, T cells, Brain, B cells, Endothelial, Testes, Lymph node, Bone, Thyroid, Skin, Placenta, Salivary gland, Pancreas, Ovary, Spinal cord, Monocytes, Whole blood, Cervix

Animal Models for Breast Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Breast Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
endocrine/exocrine gland phenotype
MP:000537910.4CA9, NPR1, NPPC, CTSK, AREG, PTPN6
2
immune system phenotype
MP:000538710.1PTPN6, KCNN4, CCNA2, NPR1, CTSK, MDK

Publications for Breast Adenocarcinoma

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Sources:
50PubMed
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Articles related to Breast Adenocarcinoma:

(show top 50)    (show all 302)
idTitleAuthorsYear
1
Gemifloxacin inhibits migration and invasion and induces mesenchymal-epithelial transition in human breast adenocarcinoma cells. (24005829)
2014
2
Human breast adenocarcinoma cytotoxicity and modulation of 7,12-dimethylbenz[a]anthracene-induced mammary carcinoma in Balb/c mice by Acacia catechu (L.f.) Wild heartwood. (23142797)
2013
3
In vitro cytotoxic activity of Aesculus indica against breast adenocarcinoma cell line (MCF-7) and phytochemical analysis. (22186328)
2012
4
ERK-modulated intrinsic signaling and G(2)/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells. (23008020)
2012
5
Neohesperidin induces cellular apoptosis in human breast adenocarcinoma MDA-MB-231 cells via activating the Bcl-2/Bax-mediated signaling pathway. (23285810)
2012
6
Synthesis and anticancer effects of some novel pyrazolo[3,4-d]pyrimidine derivatives by generating reactive oxygen species in human breast adenocarcinoma cells. (21315495)
2011
7
Fangchinoline inhibits breast adenocarcinoma proliferation by inducing apoptosis. (22130369)
2011
8
Synthesis and in vitro cytotoxic activity of novel pyrazolo[3,4-d]pyrimidines and related pyrazole hydrazones toward breast adenocarcinoma MCF-7 cell line. (22000322)
2011
9
Metastatic seeding of colon adenocarcinoma manifesting as synchronous breast and chest wall localization: report of a case. (21264761)
2011
10
Transcriptional analysis of novel hormone receptors PGRMC1 and PGRMC2 as potential biomarkers of breast adenocarcinoma staging. (20655063)
2011
11
Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate. (20924379)
2010
12
Mucinous adenocarcinoma of the breast metastatic to the placenta. (21080884)
2010
13
PET study on mice bearing human colon adenocarcinoma cells using [11C]GF120918, a dual radioligand for P-glycoprotein and breast cancer resistance protein. (20859232)
2010
14
The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells. (19631373)
2009
15
Tricetin, a dietary flavonoid, inhibits proliferation of human breast adenocarcinoma mcf-7 cells by blocking cell cycle progression and inducing apoptosis. (19705844)
2009
16
Gene expression of 17beta-estradiol-metabolizing isozymes: comparison of normal human mammary gland to normal human liver and to cultured human breast adenocarcinoma cells. (18497089)
2008
17
Serous papillary adenocarcinoma of the female genital organs and invasive micropapillary carcinoma of the breast. Are WT1, CA125, and GCDFP-15 useful in differential diagnosis? (18339419)
2008
18
Breast adenocarcinoma MCF-7 cell line induces spontaneous osteoclastogenesis via a RANK-ligand-dependent pathway. (18406448)
2008
19
Mucinous adenocarcinoma of the rectum with breast and ocular metastases. (16644510)
2006
20
Multiple cutaneous acral metastases in a woman with breast adenocarcinoma treated with pegylated liposomal doxorubicin: incidental or aetiological association? (15952972)
2005
21
Utility of immunohistochemistry in distinguishing primary adenocarcinomas from metastatic breast carcinomas in the gastrointestinal tract. (15737028)
2005
22
The role of ICP0-Null HSV-1 and interferon signaling defects in the effective treatment of breast adenocarcinoma. (16140040)
2005
23
Four peptide hormones decrease the number of human breast adenocarcinoma cells. (15638821)
2005
24
Improved grading of breast adenocarcinomas based on genomic instability. (14871819)
2004
25
Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia. (15054467)
2004
26
The multidrug resistance modulator SDZ-PSC 833 potentiates the photodynamic activity of chlorin e6 independently of P-glycoprotein in multidrug resistant human breast adenocarcinoma cells. (12632062)
2003
27
Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. (12193750)
2002
28
Retinoblastoma function is a better indicator of cellular phenotype in cultured breast adenocarcinoma cells than retinoblastoma expression. (11976406)
2002
29
Ras and Rho protein induction of motility and invasion in T47D breast adenocarcinoma cells. (11400341)
2001
30
Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells. (11313718)
2001
31
Lobular carcinoma of the breast metastatic to the oral cavity mimicking polymorphous low-grade adenocarcinoma of the minor salivary glands. (10629151)
2000
32
The S387Y mutations of the transforming growth factor-beta receptor type I gene is uncommon in metastases of breast cancer and other common types of adenocarcinoma. (10416594)
1999
33
Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells. (10023317)
1998
34
Inhibition of apoptosis is the cause of resistance to doxorubicin in human breast adenocarcinoma cells. (9890665)
1998
35
Radioimmunoscintigraphy in patients with breast adenocarcinoma using technetium-99m labelled monoclonal antibody 170H.82: report of a phase II study. (9096088)
1997
36
Expression of ALDH3 and NMO1 in human corneal epithelial and breast adenocarcinoma cells. (9059607)
1997
37
Pre-operative assessment of axillary lymph node status in patients with breast adenocarcinoma using intravenous 99mtechnetium mAb-170H.82 (Tru-Scint AD). (9285114)
1997
38
Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF7) cell line. (9194421)
1997
39
Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. (7671262)
1995
40
Effects of TGF-beta 1 (transforming growth factor-beta 1) on the cell cycle regulation of human breast adenocarcinoma (MCF-7) cells. (7729516)
1995
41
Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance. (8328987)
1993
42
Expression of mRNA for cytokines in tumor-infiltrating mononuclear cells in ovarian adenocarcinoma and invasive breast cancer. (1601521)
1992
43
Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells. (1709586)
1991
44
Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7. (1883381)
1991
45
Expression of laminin by human fibroblasts, HT1080 fibrosarcoma cells and MCF-7 breast adenocarcinoma cells. Lack of regulation by the cell density and extracellular matrix. (1742797)
1991
46
Primary adenocarcinoma of the breast arising in the vulva. (2199874)
1990
47
Histological and ultrastructural changes in breast adenocarcinoma after treatment with plasma perfused over immobilized protein A. (6713411)
1984
48
A retrovirus-producing transformed mouse cell line derived from a human breast adenocarcinoma transplanted in a nude mouse. (6309650)
1983
49
Phase II trial of spirogermanium in breast adenocarcinoma: a Cancer and Leukemia Group B Study. (7105058)
1982
50
Delayed-type skin hypersensitivity reaction (DTH) to Thomsen-Friedenreich (T) antigen as diagnostic test for human breast adenocarcinoma. (228112)
1979

Genetic Variations for Breast Adenocarcinoma

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Expression for genes affiliated with Breast Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Adenocarcinoma

Search GEO for disease gene expression data for Breast Adenocarcinoma.

Pathways for genes affiliated with Breast Adenocarcinoma

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51QIAGEN
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Pathways related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
PAK Pathway51
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10.4PTPN6, CXCL10, CXCR3, AREG, MDK

Compounds for genes affiliated with Breast Adenocarcinoma

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8WISP2
28-bromo cgmp4410.8CCNA2, NPR1, NPPC
3thymidine44 2411.8PTPN6, KCNN4, CCNA2, NPPC, AREG, CXCR3
4forskolin44 49 1112.8CCNA2, NPR1, NPPC, AREG, CXCL10
5retinoic acid44 2411.8CCNA2, NPPC, CTSK, MDK, AREG, CXCL10
6heparan sulfate44 2411.8MDK, AREG, CXCR3, CXCL10
7tetraethylammonium44 28 1112.8KCNN4, KCNA3, NPPC
8cl-4as-15910.8AREG, AREGB
9progesterone44 59 28 11 2414.8CCNA2, CA9, WISP2, AREG, CXCR3, CXCL10
10serine4410.8C1RL, CCNA2, NPR1, NPPC, CTSK, AREG
11nitric oxide44 11 2412.8CCNA2, NPR1, NPPC, CXCR3, CXCL10, PTPN6
12calcium44 49 11 2413.8KCNN4, CCNA2, CA9, NPPC, CTSK, AREG
13vegf4410.8CCNA2, CA9, AREG, CXCR3, CXCL10, PTPN6
14chloride4410.8KCNN4, CA9, NPPC, CTSK
15urodilatin4410.7NPPC, NPR1
16iudr4410.7CA9, CCNA2
17tyrosine4410.7CCNA2, CA9, NPPC, CTSK, AREG, CXCR3
18lipid4410.7CCNA2, NPPC, MDK, CXCL10, PTPN6, SPAM1
19heparin44 28 11 2413.7WISP2, AREG, CXCR3
20iberiotoxin44 59 2812.7NPPC, KCNN4
21nilutamide44 59 28 1113.7AREG, AREGB
22mitomycin c4410.6CA9, AREG, ALDH3A1
23histamine44 28 2412.6CXCL10, CXCR3, NPPC, KCNN4
24charybdotoxin44 2811.6KCNA3, KCNN4
25glycosaminoglycan4410.5AREG, CXCL10, SPAM1
26sodium nitroprusside4410.5CXCR3, NPPC, NPR1
27genistein44 28 59 2 11 2415.5PTPN6, CXCL10, NPPC, CCNA2
28phorbol4410.4PTPN6, NPPC, CCNA2
29dexamethasone44 49 28 1113.2CCNA2, NPPC, AREG

GO Terms for genes affiliated with Breast Adenocarcinoma

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16Gene Ontology
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Cellular components related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4CXCL10, AREGB, CTSK, NPPC, WISP2, C1RL

Biological processes related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cGMP biosynthetic processGO:03082810.5NPPC, NPR1
2regulation of blood vessel sizeGO:05088010.5NPPC, NPR1
3cGMP biosynthetic processGO:00618210.4NPPC, NPR1
4receptor guanylyl cyclase signaling pathwayGO:00716810.2NPPC, NPR1

Products for genes affiliated with Breast Adenocarcinoma

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  • Antibodies
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Sources for Breast Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet
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