Breast Adenocarcinoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Breast Adenocarcinoma

Sources:
⁹Disease Ontology, ³²MalaCards
See all sources

Disease Ontology:⁹ A breast carcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast.

MalaCards based summary: Breast Adenocarcinoma, also known as mammary adenocarcinoma, is related to adenocarcinoma and breast cancer. An important gene associated with Breast Adenocarcinoma is AKT1 (v-akt murine thymoma viral oncogene homolog 1), and among its related pathways are a6b1 and a6b4 Integrin signaling and G protein signaling Cross talk between Ras family GTPases. The compounds ptdins(3)p and everolimus have been mentioned in the context of this disorder. Affiliated tissues include breast, colon and brain, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Breast Adenocarcinoma

Sources:
⁹Disease Ontology, ⁶¹UMLS, ³⁹NCIt
See all sources

Breast Adenocarcinoma, Aliases & Descriptions:

Name: Breast Adenocarcinoma ⁹ ⁶¹

Mammary Adenocarcinoma ⁹ ⁶¹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Reproductive diseases

External Ids:

Disease Ontology⁹ DOID:3458

NCIt³⁹ C5214

UMLS⁶¹ C0858252

Related Diseases for Breast Adenocarcinoma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases in the Breast Adenocarcinoma family:

Rare Adenocarcinoma of the Breast

Diseases related to Breast Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)

id	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma	30.6	NPPC, NPR1, ALDH3A1, AKT1, NQO1, PIK3CA
2	breast cancer	29.9	PIK3CA, NQO1, AKT1
3	prostate cancer	29.3	CTSK, AKT1, NQO1, PIK3CA
4	colorectal cancer	29.2	PIK3CA, NQO1, AKT1, AREGB
5	sarcoma	10.2
6	skeletal dysplasia multi-gene panels	10.2	CTSK, NPPC
7	leukemia	10.1
8	cervicitis	10.1
9	prostatitis	10.1
10	somatostatin analog	10.1
11	endotheliitis	10.1
12	adenoma	10.1
13	pituitary adenoma	10.1
14	estrogen resistance	10.1
15	ovarian cancer, somatic	10.0	PIK3CA, AKT1
16	colorectal cancer, somatic	10.0	AKT1, PIK3CA
17	b-cell lymphomas	10.0
18	cervical squamous cell carcinoma	10.0
19	hepatocellular carcinoma	10.0
20	cauda equina syndrome	10.0
21	apocrine adenocarcinoma	10.0
22	fibrosarcoma	10.0
23	keratosis	10.0
24	lung squamous cell carcinoma	10.0
25	mediastinitis	10.0
26	melanoma	10.0
27	meningioma	10.0
28	neuroblastoma	10.0
29	prostate adenocarcinoma	10.0
30	retinoblastoma	10.0
31	seborrheic keratosis	10.0
32	t-cell leukemia	10.0
33	osteochondroma	10.0
34	hypoxia	10.0
35	erythrocytosis	10.0
36	colon adenocarcinoma	9.9	NQO1, NPR1, NPPC
37	lung adenocarcinoma	9.8	PIK3CA, NQO1, CTSK
38	congenital heart disease	9.7	AKT1, NPR1, NPPC
39	kidney cancer	9.6	PIK3CA, AKT1, NPR1, NPPC
40	atherosclerosis	9.5	NQO1, AKT1, NPPC, CTSK
41	liver cancer	9.5	PIK3CA, NQO1, AKT1, ALDH3A1
42	stomach cancer	9.5	PIK3CA, NQO1, AKT1
43	lung cancer	9.4	PIK3CA, NQO1, AKT1, CTSK

Graphical network of the top 20 diseases related to Breast Adenocarcinoma:

Symptoms for Breast Adenocarcinoma

Drugs & Therapeutics for Breast Adenocarcinoma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Breast Adenocarcinoma

Search NIH Clinical Center for Breast Adenocarcinoma

Genetic Tests for Breast Adenocarcinoma

Anatomical Context for Breast Adenocarcinoma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Breast Adenocarcinoma:

³²

Breast, Colon, Brain, Liver, Bone, Lymph node, Prostate, T cells, Endothelial, Whole blood, Spinal cord, Lung, Pancreas, Skin, Testes, Monocytes, B cells

Animal Models for Breast Adenocarcinoma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Breast Adenocarcinoma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	8.4	CTSK, NPPC, NPR1, AKT1, KCNA3, NQO1

Publications for Breast Adenocarcinoma

Sources:
⁵¹PubMed
See all sources

Articles related to Breast Adenocarcinoma:

(show top 50) (show all 246)

id	Title	Authors	Year
1	Lipid Peroxidation and Altered Anti-oxidant Status in Breast Adenocarcinoma Patients. (25050522)	Wang C.... Wu N.	2014
2	XIAP inhibitor and antiestrogen embelin abrogates metastasis and augments apoptosis in estrogen receptor positive human breast adenocarcinoma cell line MCF-7. (24390234)	Sumalatha K.R.... Sreepriya M.	2014
3	Gemifloxacin inhibits migration and invasion and induces mesenchymal-epithelial transition in human breast adenocarcinoma cells. (24005829)	Chen T.C.... Chen Y.H.	2014
4	The in vitro influences of epidermal growth factor and heregulin-I^1 on the efficacy of trastuzumab used in Her-2 positive breast adenocarcinoma. (24119761)	Hurrell T.... Outhoff K.	2013
5	Induction of apoptosis in human breast adenocarcinoma cells MCF-7 by monapurpyridine A, a new azaphilone derivative from Monascus purpureus NTU 568. (22237681)	Hsu L.C.... Pan T.M.	2012
6	Treatment of breast adenocarcinoma metastasis to the neck: dedifferentiation of the tumor as suggested by hormone markers. (22038868)	Sproson E.L.... Puxeddu R.	2012
7	4-Shogaol, an active constituent of dietary ginger, inhibits metastasis of MDA-MB-231 human breast adenocarcinoma cells by decreasing the repression of NF-I_B/Snail on RKIP. (22224671)	Hsu Y.L.... Hou M.F.	2012
8	Regulation of CD1, Ki-67, PCNA mRNA expression, and Akt activation in estrogen-responsive human breast adenocarcinoma cell line, MCF-7 cells, by griffonianone C, an isoflavone derived from Millettia griffoniana. (21284537)	Magloire Ketcha Wanda G.J.... Vollmer G.	2011
9	The influence of phenothiazine derivatives on doxorubicin treatment in sensitive and resistant human breast adenocarcinoma cells. (22264721)	Kuzma-Richeret A.... Kulbacka J.	2011
10	Synthesis and anticancer effects of some novel pyrazolo[3,4-d]pyrimidine derivatives by generating reactive oxygen species in human breast adenocarcinoma cells. (21315495)	Rashad A.E.... Ali M.M.	2011
11	A proposed anatomical explanation for perineural spread of breast adenocarcinoma to the brachial plexus. (21154646)	HAcbert-Blouin M.N.... Spinner R.J.	2011
12	In vitro effects of 2-methoxyestradiol-bis-sulphamate on reactive oxygen species and possible apoptosis induction in a breast adenocarcinoma cell line. (22152028)	Visagie M.H.... Joubert A.M.	2011
13	Modulation of DNA methylation levels sensitizes doxorubicin-resistant breast adenocarcinoma cells to radiation-induced apoptosis. (20034463)	Luzhna L.... Kovalchuk O.	2010
14	Primary human breast adenocarcinoma: imaging and histologic correlates of intrinsic susceptibility-weighted MR imaging before and during chemotherapy. (20858850)	Li S.P.... Padhani A.R.	2010
15	Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate. (20924379)	Witney T.H.... Brindle K.M.	2010
16	Effects of Leuzea carthamoides on human breast adenocarcinoma MCF-7 cells determined by gene expression profiling and functional assays. (18975255)	Gaube F.... HAMBURGER M.	2008
17	Selenocystine induces S-phase arrest and apoptosis in human breast adenocarcinoma MCF-7 cells by modulating ERK and Akt phosphorylation. (18959417)	Chen T.... Wong Y.S.	2008
18	Human breast adenocarcinoma (MDA-231) and human lung squamous cell carcinoma (Hara) do not have the ability to cause bone resorption by themselves during the establishment of bone metastasis. (18301992)	Tomita A.... Nakajima M.	2008
19	Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells. (18695915)	Ravizza R.... Monti E.	2008
20	Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets. (17363502)	Chekhun V.F.... Pogribny I.P.	2007
21	Silencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4T1 breast adenocarcinoma cell. (16340246)	Bausero M.A.... Asea A.	2006
22	Spinal cord compression in a patient with multiple hereditary exostoses caused by breast adenocarcinoma metastatic to osteochondromas of the spine: case report. (17108823)	Pandya N.K.... Chin K.R.	2006
23	Bilateral metastatic breast adenocarcinoma within the temporomandibular joint: a case report. (16546656)	Miles B.A.... Kessler H.P.	2006
24	Hyperthermia engages the intrinsic apoptotic pathway by enhancing upstream caspase activation to overcome apoptotic resistance in MCF-7 breast adenocarcinoma cells. (16440323)	Klostergaard J.... Donato N.J.	2006
25	Distant metastasis from subcutaneously grown E0771 medullary breast adenocarcinoma. (16312045)	Ewens A.... Ehrke M.J.	2005
26	Calcified metastatic mediastinal lymph nodes from mucinous breast adenocarcinoma. (14566424)	Preda L.... Bellomi M.	2004
27	Effect of pH on uptake and photodynamic action of chlorin p6 on human colon and breast adenocarcinoma cell lines. (14872242)	Sharma M.... Kumar Gupta P.	2004
28	Neuroendocrine differentiation and prognosis in breast adenocarcinoma. (11895486)	Miremadi A.... Ellis I.O.	2002
29	Ras and Rho protein induction of motility and invasion in T47D breast adenocarcinoma cells. (11400341)	Keely P.J.	2001
30	P1, a high mobility group-like protein is depressed in human breast adenocarcinoma. (11544097)	Photopoulou A.... Aleporou-Marinou V.	2001
31	17beta-estradiol inhibits forskolin-induced vascular endothelial growth factor promoter in MCF-7 breast adenocarcinoma cells. (11717004)	Bermont L.... Adessi G.L.	2001
32	Metastatic breast adenocarcinoma diagnosed by aspiration of a pulmonary artery embolism. (10740622)	Chan T.Y.... Ali S.Z.	2000
33	Expression of transforming growth factor-beta receptor type II and tumorigenicity in human breast adenocarcinoma MCF-7 cells. (9648930)	Ko Y.... Brattain M.G.	1998
34	Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells. (10023317)	Constantinou A.I.... Murley J.S.	1998
35	Characterization of human breast adenocarcinoma SK-BR-3 cells resistant to doxorubicin. (9372856)	Osmak M.... Skrk J.	1997
36	Involvement of p21 in mitotic exit after paclitaxel treatment in MCF-7 breast adenocarcinoma cell line. (9419978)	Barboule N.... Valette A.	1997
37	Radioimmunoscintigraphy in patients with breast adenocarcinoma using technetium-99m labelled monoclonal antibody 170H.82: report of a phase II study. (9096088)	McQuarrie S.A.... McEwan A.J.	1997
38	Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. (7671262)	Krajewski S.... Reed J.C.	1995
39	Early gene responses associated with transforming growth factor-beta 1 growth inhibition and autoinduction in MCF-7 breast adenocarcinoma cells. (7766715)	Lafon C.... Valette A.	1995
40	Fine-needle aspiration cytology in locally advanced breast adenocarcinoma: a case with complete response to preoperative chemotherapy in association with granulomatous inflammatory reaction. (7924810)	Costa M.J.... Goodnight J.E.	1994
41	Identification of the class-3 aldehyde dehydrogenases present in human MCF-7/0 breast adenocarcinoma cells and normal human breast tissue. (8068047)	Sreerama L.... Sladek N.E.	1994
42	Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts. (8217606)	NoAl A.... Foidart J.M.	1993
43	Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells. (1709586)	Jerome K.R.... Finn O.J.	1991
44	Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7. (1883381)	Shoyab M.... Plowman G.D.	1991
45	Erythrocytosis caused by an erythropoietin-producing breast adenocarcinoma. (2161586)	Bohnen R.F.... Zanjani E.D.	1990
46	Growth modulation effects of synthetic steroids on rat prostatic adenocarcinoma and human breast adenocarcinoma cells in vitro. (2357267)	Mickey D.D.... Petrow V.	1990
47	Effects of three new folate antagonists on human breast adenocarcinoma cells in vitro and on immune responses in vivo. (6692721)	Tsang K.Y.... Pan J.F.	1984
48	A retrovirus-producing transformed mouse cell line derived from a human breast adenocarcinoma transplanted in a nude mouse. (6309650)	Bowen J.M.... Siciliano M.J.	1983
49	Seborrheic keratosis and papillomatosis: markers of breast adenocarcinoma. (6225626)	Friedman-Birnbaum R.... Haim S.	1983
50	Metastatic breast adenocarcinoma to Brenner tumors. (7372198)	Smale L.E.	1980

Genes related to Breast Adenocarcinoma

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals, ⁷Clinvar
See all sources

Genes related to Breast Adenocarcinoma:

(show all 15)

- Elite gene

id	Symbol	Description	Score	Implication
1	AKT1	v-akt murine thymoma viral oncogene homolog 1	20.57	Pathogenic ⁷ GeneCards inferred via : Publications (show sections)
2	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	18.67	Pathogenic ⁷
3	CST9	cystatin 9 (testatin)	17.90	GeneCards inferred via : Expressions (show sections)
4	IGHA1	immunoglobulin heavy constant alpha 1	16.57	GeneCards inferred via : Publications (show sections)
5	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	15.24	GeneCards inferred via : Publications (show sections)
6	NPPC	natriuretic peptide C	13.90	GeneCards inferred via : Publications (show sections)
7	CTSK	cathepsin K	12.57	GeneCards inferred via : Publications (show sections)
8	NPR1	natriuretic peptide receptor 1	11.24	GeneCards inferred via : Publications (show sections)
9	NQO1	NAD(P)H dehydrogenase, quinone 1	9.90	GeneCards inferred via : Publications (show sections)
10	CHMP2A	charged multivesicular body protein 2A	8.85	GeneCards inferred via : Gene name (show sections)
11	NANOGP8	Nanog homeobox pseudogene 8	7.24	GeneCards inferred via : Expressions (show sections)
12	AREGB	amphiregulin B	5.90	GeneCards inferred via : Publications (show sections)
13	ALDH3A1	aldehyde dehydrogenase 3 family, member A1	4.57	GeneCards inferred via : Publications (show sections)
14	C1RL	complement component 1, r subcomponent-like	3.24	GeneCards inferred via : Expressions (show sections)
15	WISP2	WNT1 inducible signaling pathway protein 2	1.90	GeneCards inferred via : Publications (show sections)

Products for genes related to Breast Adenocarcinoma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	15	-	15	15
2	Novus Biologicals	13	13	14	-

Variations for Breast Adenocarcinoma

Sources:
⁷Clinvar
See all sources

Clinvar genetic disease variations for Breast Adenocarcinoma:

⁷

id	Gene	Name	Type	Significance	SNP ID	Assembly	Location
1	PIK3CA	NM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)	single nucleotide variant	Pathogenic	rs121913279	GRCh37	Chr 3, 178952085: 178952085
2	PIK3CA	NM_006218.2(PIK3CA): c.3140A> T (p.His1047Leu)	single nucleotide variant	Pathogenic	rs121913279	GRCh37	Chr 3, 178952085: 178952085
3	PIK3CA	NM_006218.2(PIK3CA): c.1633G> A (p.Glu545Lys)	single nucleotide variant	Pathogenic	rs104886003	GRCh37	Chr 3, 178936091: 178936091
4	AKT1	NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)	single nucleotide variant	Pathogenic	rs121434592	GRCh37	Chr 14, 105246551: 105246551

Expression for genes affiliated with Breast Adenocarcinoma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Breast Adenocarcinoma

Search GEO for disease gene expression data for Breast Adenocarcinoma.

Pathways for genes affiliated with Breast Adenocarcinoma

Sources:
⁴⁹PathCards, ³⁷NCBI BioSystems Database, ⁵⁹Thomson Reuters, ⁶⁰Tocris Bioscience, ⁵⁴Reactome, ⁵Cell Signaling Technology, ³⁰KEGG, ⁵⁰PharmGKB, ⁵²QIAGEN
See all sources

Pathways related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

(show all 25)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	a6b1 and a6b4 Integrin signaling³⁷	10.0	PIK3CA, AKT1
2	G protein signaling Cross talk between Ras family GTPases⁵⁹	10.0	PIK3CA, AKT1
3	CXCR3-mediated signaling events³⁷	10.0	PIK3CA, AKT1
4	IL6-mediated signaling events³⁷	10.0	PIK3CA, AKT1
5	Insulin Pathway⁶⁰ Show member pathways Insulin Pathway³⁷	10.0	PIK3CA, AKT1
6	Signaling events mediated by the Hedgehog family³⁷	10.0	PIK3CA, AKT1
7	IGF1 pathway³⁷	10.0	PIK3CA, AKT1
8	E-cadherin signaling in keratinocytes³⁷	10.0	AKT1, PIK3CA
9	Regulation of Microtubule Cytoskeleton³⁷	10.0	AKT1, PIK3CA
10	Trk receptor signaling mediated by PI3K and PLC-gamma³⁷	10.0	AKT1, PIK3CA
11	E-cadherin signaling in the nascent adherens junction³⁷	10.0	AKT1, PIK3CA
12	TSLP Signaling Pathway³⁷	10.0	AKT1, PIK3CA
13	Nongenotropic Androgen signaling³⁷	10.0	AKT1, PIK3CA
14	Reelin signaling pathway³⁷	10.0	AKT1, PIK3CA
15	VEGFR3 signaling in lymphatic endothelium³⁷ Show member pathways Fibronectin matrix formation⁵⁴	10.0	AKT1, PIK3CA
16	Angiogenesis⁵ Show member pathways Angiogenesis³⁷	10.0	AKT1, PIK3CA
17	Plasma membrane estrogen receptor signaling³⁷	10.0	AKT1, PIK3CA
18	Estrogen signaling pathway³⁷	10.0	AKT1, PIK3CA
19	Nephrin/Neph1 signaling in the kidney podocyte³⁷	10.0	AKT1, PIK3CA
20	Keap1-Nrf2 Pathway³⁷	9.9	NQO1, PIK3CA
21	FSH signaling pathway³⁷	9.7	AKT1, AREGB
22	Osteoclast differentiation³⁰	9.7	PIK3CA, AKT1, CTSK
23	Toll-like receptor signaling pathway³⁰ Show member pathways Chagas disease (American trypanosomiasis)³⁰ Toll-like receptor signaling pathway³⁷ Regulation of toll-like receptor signaling pathway³⁷ Hepatitis B³⁰	9.7	CTSK, AKT1, PIK3CA
24	ErbB signaling pathway³⁰ Show member pathways ErbB receptor signaling network³⁷ ErbB signaling pathway³⁷ EGFR Inhibitor Pathway, Pharmacodynamics⁵⁰	9.5	AREGB, AKT1, PIK3CA
25	AHR Pathway⁵² Show member pathways AhR pathway³⁷	9.5	ALDH3A1, NQO1

Compounds for genes affiliated with Breast Adenocarcinoma

Sources:
⁴⁴Novoseek, ⁵⁰PharmGKB, ¹²DrugBank, ⁶⁰Tocris Bioscience, ²⁵HMDB, ²⁹IUPHAR
See all sources

Compounds related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

(show all 20)

id	Compound	Score	Top Affiliating Genes
1	ptdins(3)p⁴⁴	10.2	AKT1, PIK3CA
2	everolimus⁴⁴ ⁵⁰ ¹²	12.2	AKT1, PIK3CA
3	urodilatin⁴⁴	10.1	NPPC, NPR1
4	8-bromo cgmp⁴⁴	10.1	NPPC, NPR1
5	l-nmma⁴⁴	10.0	PIK3CA, AKT1, NPPC
6	bcnu⁴⁴	10.0	AKT1, NQO1
7	quercetin⁴⁴ ⁶⁰ ²⁵ ¹²	12.9	PIK3CA, NQO1, AKT1
8	arsenite⁴⁴ ²⁵	10.8	PIK3CA, NQO1, AKT1
9	mafosfamide⁴⁴	9.8	NQO1, ALDH3A1
10	17-(allylamino)-17-demethoxygeldanamycin⁴⁴	9.8	AKT1, NQO1
11	agar⁴⁴	9.7	AKT1, NQO1, PIK3CA
12	indole-3-carbinol⁴⁴	9.6	AKT1, NQO1
13	tcdd⁴⁴	9.5	ALDH3A1, NQO1
14	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	12.3	PIK3CA, NQO1, AKT1, NPPC
15	nadph⁴⁴ ²⁵	10.3	ALDH3A1, AKT1, NQO1, PIK3CA
16	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	12.1	AREGB, NPPC, AKT1, NQO1, PIK3CA
17	estrogen⁴⁴	9.0	PIK3CA, NQO1, WISP2, AKT1, NPR1
18	retinoic acid⁴⁴ ²⁵	10.0	CTSK, NPPC, ALDH3A1, AKT1, PIK3CA
19	cysteine⁴⁴	8.7	NQO1, WISP2, AKT1, NPR1, NPPC, CTSK
20	serine⁴⁴	8.2	CTSK, PIK3CA, C1RL, NQO1, AKT1, NPR1

GO Terms for genes affiliated with Breast Adenocarcinoma

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	7.1	AREGB, CTSK, NPPC, ALDH3A1, WISP2, IGHA1

Biological processes related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	cGMP biosynthetic process	GO:006182	10.1	NPPC, NPR1
2	positive regulation of cGMP biosynthetic process	GO:030828	10.0	NPPC, NPR1
3	receptor guanylyl cyclase signaling pathway	GO:007168	10.0	NPPC, NPR1
4	nitric oxide biosynthetic process	GO:006809	10.0	AKT1, NQO1
5	regulation of blood vessel size	GO:050880	9.9	NPR1, NPPC
6	regulation of multicellular organism growth	GO:040014	9.8	NPPC, PIK3CA
7	protein kinase B signaling	GO:043491	9.7	PIK3CA, AKT1
8	epidermal growth factor receptor signaling pathway	GO:007173	9.5	AREGB, AKT1, PIK3CA
9	aging	GO:007568	9.4	NQO1, AKT1, ALDH3A1
10	innate immune response	GO:045087	8.9	CTSK, AKT1, C1RL, PIK3CA