Breast Adenocarcinoma malady

Disease Ontology: An adenocarcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast.⁶

MalaCards: Breast Adenocarcinoma, also known as mammary adenocarcinoma, is related to squamous cell carcinoma and colorectal cancer. An important gene associated with Breast Adenocarcinoma is CHMP2A (charged multivesicular body protein 2A), and among its related pathways are Colorectal cancer and Glioma Invasiveness. The compounds egcg and phosphatidylserine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and breast, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

breast adenocarcinoma 6 43 mammary adenocarcinoma 6

Diseases related to breast adenocarcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 819)

id	Related Disease	Score	Top Affiliating Genes
1	squamous cell carcinoma	28.3	MKI67, GSTP1, CCNA2, TP73, ODC1, EGF
2	colorectal cancer	27.3	CHEK2, GSTP1, TP53, TNF, CYP1A1, NQO1
3	breast cancer	25.9	VEGFA, BCL2, CHEK2, MMP1, MMP2, MMP9
4	adenocarcinoma	21.2	PCNA, RB1, SERPINE1, NANOGP8, NACA, VEGFA
5	hypoxia	14.3	PCNA, RB1, SERPINE1, NACA, VEGFA, BMP6
6	thoracic aortic aneurysm	13.7	MMP1, MMP2, TGFBR2
7	osteogenesis imperfecta type 4	13.7	CD36, DSPP, GGT1
8	reticulosarcoma	13.6	PARP1, BCL2, CDKN1B, CTSD, CXCR3
9	transient cerebral ischemia	13.6	BCL2, FOS, TUBA1B, ODC1, CTSD
10	spinal-bulbar muscular atrophy	13.6	AREGB, AREG, TGFB1, TGFBR2
11	cutaneous t cell lymphoma	13.6	BAX, FAS, PTPN6, CXCL10, CXCR3
12	monoclonal gammopathy of undetermined significance	13.6	CDKN1B, CA9, TP73, TNFSF11, NEU1
13	alcoholism	13.6	ALDH1A1, ALDH9A1, HMGCR, CYCS, SP1, NEU1
14	congestive heart failure	13.6	FN1, HMGCR, NPPA, NPPB, NPPC, NPR1
15	pulmonary hypertension	13.6	CAV1, RHOD, TGFBR2, NPPA, NPPB
16	inverted papilloma	13.5	PCNA, CDKN1B, MKI67
17	anaplastic plasmacytoma	13.5	PCNA, MKI67, HSPB1, PLAU
18	inclusion body myositis	13.5	BCL2, BAX, CD36, CAV1, THBS1, CXCR3
19	aneurysm disease	13.4	MMP1, MMP14, MMP2, MMP9, CTSD, TGFBR2
20	ulceration of vulva	13.4	MMP1, FOS, FN1, AREG, HSPB1, EGF
21	hepatocellular carcinoma (fibrolamellar variant)	13.4	MMP2, MMP9, PLAU, PLAUR
22	root resorption	13.4	MMP9, TNFSF11, CTSK, DSPP
23	colonic disease	13.4	CTSD, PLAU, EGFR, ADAMTSL1
24	ovarian cancer	13.4	RB1, CHEK2, CDKN1A, CDKN1B, CCNA2
25	porphyria cutanea tarda	13.4	BMP6, CD36, HMGCR, CYP1A1, AHR, GGT1
26	giant cell tumor	13.4	MMP9, TNFSF11, CTSK, PLAUR, CSF1
27	secondary syphilis	13.4	CD36, FOS, TNFSF11, CTSK, CSF1
28	cluttering	13.4	MMP2, TGFB1, CXCL10
29	paranasal sinus disease	13.4	SERPINE1, PLAU, PLAUR
30	breast malignant phyllodes tumor	13.4	MKI67, CCNA2, PGR
31	alexia	13.4	PARP1, FAS, AKT1, TP73, CTSD
32	variegate porphyria	13.4	BMP6, CD36, HMGCR, CYP1A1, AHR, GGT1
33	refractive error	13.4	MMP1, MMP14, MMP2, MMP9, TIMP1
34	adenoameloblastoma	13.4	PCNA, CDKN1B, MMP2, TNFSF11, DSPP
35	odontogenic myxoma	13.4	CD36, MMP1, MMP2, MMP9
36	osteopenia/osteoporosis	13.3	LEP, CD36, TNFSF11, CTSK
37	conjunctivochalasis	13.3	MMP1, MMP2, MMP9, PLAU, TIMP1
38	alport syndrome	13.3	BMP6, LAMB1, HMGCR, TGFB1, GGT1
39	fibromatosis, gingival	13.3	CD36, MMP1, MMP2, TGFB1
40	anaplastic meningioma	13.3	PCNA, PLAUR, PGR
41	periapical granuloma	13.3	MDK, TNF, TNFSF11, CXCR3
42	ischemic heart disease	13.3	SERPINE1, HMGCR, NPPA, NPPB, NPPC, NPR1
43	pediatric cns embryonal cell carcinoma	13.3	LAMB1, FOS, CCNA2, TUBA1B, TUBB, SP1
44	hypertensive heart disease	13.3	CD36, MMP1, MMP9, NPPA, NPPB, NPR1
45	prostate disease	13.3	BMP6, CTSD, PLAUR, THBS1, TGFB1
46	abdominal aortic aneurysm	13.3	MMP1, MMP14, MMP2, MMP9, PLAU, TIMP1
47	peripheral primitive neuroectodermal tumor	13.3	RB1, PARP1, IGF1R, CASP7, CASP8, SP1
48	acute lymphoblastic leukemia, childhood	13.3	PARP1, BAX, CDKN1B, GSTP1, CCNA2, CYP1A1
49	sebaceous adenoma	13.2	MKI67, ESR1, EGF
50	duchenne muscular dystrophy	13.2	LAMB1, CDKN1A, MMP2, TIMP1, NPPA, NPPB

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to breast adenocarcinoma:

²²

MGI Mouse Phenotypes related to breast adenocarcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.7	LDHA, PTPN6, SULF2, NPR1
2	endocrine/exocrine gland phenotype	MP:0005379	10.3	GGT1, NPR1, CTSK, PTPN6, KCNN4, CDKN1B
3	craniofacial phenotype	MP:0005382	9.9	MAPK8, IGF1R, ALDH1A1, TP73, SULF2, SP1
4	hematopoietic system phenotype	MP:0005397	9.4	PCNA, BCL2, KCNN4, CHEK2, LDHA, CDKN1A
5	other phenotype	MP:0005395	9.1	CSF1, CXCR3, ABCG2, ABCB1, CTSK, TP73
6	embryogenesis phenotype	MP:0005380	8.8	H19, PGR, EGFR, SP1, ODC1, CYCS
7	normal phenotype	MP:0002873	8.5	HMGCR, CYP1A1, SST, NFKBIA, TGFBR2, PGR
8	renal/urinary system phenotype	MP:0005367	8.5	SULF2, EGFR, AHR, THBS1, NPPA, H19
9	pigmentation phenotype	MP:0001186	8.2	EGFR, PTPN6, TP53, FAS, CDKN1B, LEP
10	liver/biliary system phenotype	MP:0005370	8.0	H19, AHR, ABCB1, EGFR, VEGFA, CD36
11	hearing/vestibular/ear phenotype	MP:0005377	7.6	IGF1R, TP73, PLAU, EGFR, ABCB1, CSF1
12	reproductive system phenotype	MP:0005389	7.5	VEGFA, LEP, CDKN1B, MMP14, MMP9, FOS
13	limbs/digits/tail phenotype	MP:0005371	7.4	MMP14, MMP9, FN1, FAS, IGF1R, ESR1
14	immune system phenotype	MP:0005387	7.4	KCNN4, CHEK2, LDHA, CDKN1B, MMP14, FOS
15	behavior/neurological phenotype	MP:0005386	7.2	AKT1, TP73, CYCS, SST, CTSD, PLAUR
16	nervous system phenotype	MP:0003631	6.9	CD36, ABCG2, TGFB1, CXCL10, CSF1, NEU1
17	no phenotypic analysis	MP:0003012	6.8	SST, PKM, EGFR, ABCG2, AHR, NEU1
18	integument phenotype	MP:0010771	6.6	RB1, PARP1, BCL2, CDKN1A, CDKN1B, FOS
19	digestive/alimentary phenotype	MP:0005381	6.4	CDKN1A, CD36, MMP14, MMP9, AREG, MAPK8
20	adipose tissue phenotype	MP:0005375	5.8	ESR1, TP53, TNF, NQO1, PLAU, EGFR
21	skeleton phenotype	MP:0005390	5.2	CDKN1A, MMP14, MMP2, MMP9, FOS, FN1
22	vision/eye phenotype	MP:0005391	5.1	RB1, VEGFA, BCL2, LEP, BAX, CDKN1A
23	growth/size phenotype	MP:0005378	4.9	RB1, SERPINE1, NACA, BMP6, PARP1, BCL2
24	mortality/aging	MP:0010768	4.7	RB1, TP53, TP73, TNFSF11, PTPN6, SULF2
25	tumorigenesis	MP:0002006	4.5	ESR1, TP53, TP73, TNF, NQO1, PLAU
26	muscle phenotype	MP:0005369	4.2	MMP2, CSF1, NPPA, NPPB, NPR1, PGR
27	cardiovascular system phenotype	MP:0005385	2.6	SERPINE1, NACA, VEGFA, BCL2, KCNN4, LEP
28	cellular phenotype	MP:0005384	2.3	CYCS, H19, NEU1, ODC1, CTSD, NQO1
29	homeostasis/metabolism phenotype	MP:0005376	1.7	TP73, TGFBR2, CXCL10, CXCR3, CSF1, NPPA

Articles related to breast adenocarcinoma:

(show top 50)    (show all 71)

id	Title	Authors	Year	Affiliating Genes
1	Intermediate conductance Ca2+ activated K+ channels a re expressed and functional in breast adenocarcinomas: correlation with tumour grade and metastasis status. (20712009)	Haren N.... Ouadid-Ahidouch H.	2010	KCNN4
2	alpha-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells. (20492173)	Lee Y.B.... Shih Y.W.	2010	MAPK3, MMP2, MAPK1
3	Transcriptional modulation of BCRP gene to reverse mu ltidrug resistance by toremifene in breast adenocarcinoma cells. (19967559)	Zhang Y.... Zhou G.	2010	ABCG2
4	Temporal proteomic analysis of IGF-1R signalling in M CF-7 breast adenocarcinoma cells. (20213678)	Murphy J.P.... Pinto D.M.	2010	IGF1R, LDHA, NACA
5	DNA methylation of K(v)1.3 potassium channel gene pro moter is associated with poorly differentiated breast adenocarcinoma. (19590190)	Brevet M.... Ouadid-Ahidouch H.	2009	KCNA3
6	Breast adenocarcinoma MCF-7 cell line induces spontaneous osteoclastogenesis via a RANK-ligand-dependent pathway. (18406448)	Nicolin V.... Narducci P.	2008	TNFSF11
7	Mucosal vaccination with phage-displayed tumour antigens identified through proteomics-based strategy inhibits the growth and metastasis of 4T1 breast adenocarcinoma. (18097564)	Shadidi M.... Sioud M.	2008	ALDOA, PDHX
8	Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets. (17363502)	Chekhun V.F.... Pogribny I.P.	2007	LEP, TP73, TUBA1B
9	Differential effects of quercetin and silymarin on arsenite-induced cytotoxicity in two human breast adenocarcinoma cell lines. (17931660)	Soria E.A.... Bongiovanni G.A.	2007	GGT1
10	Wild-type class I beta-tubulin sensitizes Taxol-resistant breast adenocarcinoma cells harboring a beta-tubulin mutation. (17869412)	Wiesen K.M.... Horwitz S.B.	2007	TUBB
11	Silencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4T1 breast adenocarcinoma cell. (16340246)	Bausero M.A.... Asea A.	2006	HSPB1
12	Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells. (16356834)	Chekhun V.F.... Pogribny I.P.	2006	PLAU, ABCB1, MGMT
13	Four peptide hormones decrease the number of human breast adenocarcinoma cells. (15638821)	Vesely B.A.... Vesely D.L.	2005	NPR1, NPPB, NPPA
14	Modulation of monocyte matrix metalloproteinase-2 by breast adenocarcinoma cells. (16168111)	Szabo K.A.... Singh G.	2005	MMP2, MMP1
15	Improved grading of breast adenocarcinomas based on genomic instability. (14871819)	Kronenwett U.... Auer G.	2004	CCNA2
16	The expression of the chemokine receptor CXCR3 and its ligand, CXCL10, in human breast adenocarcinoma cell lines. (15081542)	Goldberg-Bittman L.... Ben-Baruch A.	2004	CXCR3, CXCL10
17	Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia. (15054467)	Stessels F.... Vermeulen P.B.	2004	CA9
18	Overexpression of caveolin-1 induces alteration of multidrug resistance in Hs578T breast adenocarcinoma cells. (15239129)	Cai C.... Chen J.	2004	CAV1
19	HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells. (12761490)	Knuefermann C.... Fan Z.	2003	AKT1
20	Rb localization and phosphorylation kinetics correlate with the cellular phenotype of cultured breast adenocarcinoma cells. (12197776)	Botos J.... Kochevar D.T.	2002	RB1
21	Human breast adenocarcinoma cell lines promote angiogenesis by providing cells with uPA-PAI-1 and by enhancing their expression. (12124797)	Bajou K.... Foidart J.M.	2002	SERPINE1, PLAUR
22	N-terminal acylation of somatostatin analog with long chain fatty acids enhances its stability and anti-proliferative activity in human breast adenocarcinoma cells. (11824552)	Dasgupta P.... Mukherjee R.	2002	SST
23	Ras and Rho protein induction of motility and invasion in T47D breast adenocarcinoma cells. (11400341)	Keely P.J.	2001	RHOD
24	P1, a high mobility group-like protein is depressed in human breast adenocarcinoma. (11544097)	Photopoulou A.... Aleporou-Marinou V.	2001	NUCKS1
25	Genetic instability promotes the acquisition of chromosomal imbalances in T1b and T1c breast adenocarcinomas. (11455031)	Blegen H.... Ried T.	2001	CCNA2, CDKN1B
26	Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5'-upstream regions of these genes. (11306049)	Sreerama L.... Sladek N.E.	2001	CYP1A1, NQO1, ALDH3A1
27	Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells. (11313718)	Cuvillier O.... Spiegel S.	2001	FAS, CASP7, CYCS
28	Isolation and characterization of human breast adenocarcinoma cells made resistant to alpha-difluoromethylornithine. (10705873)	Das B.... Madhubala R.	2000	ODC1
29	Association of hyaluronidase and breast adenocarcinoma invasiveness. (10203600)	Madan A.K.... Beech D.J.	1999	SPAM1
30	Expression of transforming growth factor-beta receptor type II and tumorigenicity in human breast adenocarcinoma MCF-7 cells. (9648930)	Ko Y.... Brattain M.G.	1998	TGFBR2
31	H19 overexpression in breast adenocarcinoma stromal cells is associated with tumor values and steroid receptor status but independent of p53 and Ki-67 expression. (9811352)	Adriaenssens E.... Curgy J.J.	1998	PGR, MKI67, H19
32	Analysis of human breast adenocarcinoma MCF7 resistance to tumor necrosis factor-induced cell death. Lack of correlation between JNK activation and ceramide pathway. (9786905)	Ameyar M.... ChouaA^b S.	1998	MAPK8, TNF
33	Characterization of human breast adenocarcinoma SK-BR-3 cells resistant to doxorubicin. (9372856)	Osmak M.... Skrk J.	1997	CTSD
34	Induction of membrane-type matrix metalloproteinase 1 (MT1-MMP) expression in human fibroblasts by breast adenocarcinoma cells. (9062392)	Polette M.... Birembaut P.	1997	MMP14
35	Involvement of p21 in mitotic exit after paclitaxel treatment in MCF-7 breast adenocarcinoma cell line. (9419978)	Barboule N.... Valette A.	1997	CDKN1A
36	Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells. (8754775)	Srikant C.B.... Shen S.H.	1996	PTPN6, PTP4A2
37	Calcitriol and lexicalcitol (KH1060) inhibit the grow th of human breast adenocarcinoma cells by enhancing transforming growth factor -beta production. (8687506)	Mercier T.... Heberden C.	1996	TGFB1
38	Human breast adenocarcinoma MCF-7/0 cells electroporated with cytosolic class 3 aldehyde dehydrogenases obtained from tumor cells and a normal tissue exhibit differential sensitivity to mafosfamide. (8654195)	Sreerama L.... Sladek N.E.	1995	ALDH1A1, ALDH3A1
39	Thrombospondin modulates human breast adenocarcinoma cell adhesion to human vascular endothelial cells. (7805029)	Incardona F.... Legrand C.	1995	THBS1, ADAMTSL1
40	Co-culture of human breast adenocarcinoma MCF-7 cells and human dermal fibroblasts enhances the production of matrix metalloproteinases 1, 2 and 3 in fibroblasts. (7734296)	Ito A.... Mori Y.	1995	TIMP1
41	Identification of the class-3 aldehyde dehydrogenases present in human MCF-7/0 breast adenocarcinoma cells and normal human breast tissue. (8068047)	Sreerama L.... Sladek N.E.	1994	ALDH3A1
42	Analysis of epidermal growth factor receptor mRNA expression by polymerase chain reaction assay in 94 human breast adenocarcinoma tumors. (7981445)	Falette N.S.... Saez S.	1994	EGFR
43	Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis. (8271294)	Scholl S.M.... Lidereau R.	1994	CSF1
44	Coordinate enhancement of gelatinase A mRNA and activity levels in human fibroblasts in response to breast-adenocarcinoma cells. (8314319)	NoAl A.C.... Foidart J.M.	1994	MMP2
45	Hyperviscosity syndrome in disseminated breast adenocarcinoma. (8165031)	Grigg A.P.... Parkin D.	1994	NEU1
46	Involvement of thrombospondin in the adherence of human breast-adenocarcinoma cells: a possible role in the metastatic process. (8375932)	Incardona F.... Legrand C.	1993	FN1, THBS1, ADAMTSL1
47	Regulation by protein kinase C of TGF-beta 1 express ion in cultured cells of breast adenocarcinoma (1421693)	Guerrin M.... Valette A.	1992	TGFB1
48	Effect of epidermal growth factor in HLA class I and class II transcription and protein expression in human breast adenocarcinoma cell lines. (1637682)	Bernard D.J.... Plagne R.	1992	EGF
49	Antiproliferative effect of phorbol esters on MCF-7 h uman breast adenocarcinoma cells: relationship with enhanced expression of tran sforming growth-factor-beta 1. (1390899)	Guerrin M.... Valette A.	1992	TGFB1
50	Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7. (1883381)	Shoyab M.... Plowman G.D.	1991	MDK

Genes related to breast adenocarcinoma according to GeneCards:

(show top 50)    (show all 101)

id	Symbol	Description	Score	GeneCards Section Context
1	CHMP2A	charged multivesicular body protein 2A	11.1	Aliases & Descriptions, Orthologs
2	NANOGP8	Nanog homeobox pseudogene 8	10.9	Expressions
3	AREGB	amphiregulin B	10.9	Publications
4	CST9	cystatin 9 (testatin)	10.9	Expressions
5	ALDH3A1	aldehyde dehydrogenase 3 family, member A1	10.9	Publications
6	C1RL	complement component 1, r subcomponent-like	10.9	Expressions
7	MDK	midkine (neurite growth-promoting factor 2)	10.9	Publications
8	NACA	nascent polypeptide-associated complex alpha subunit	10.9	Publications
9	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	10.9	Publications
10	WISP2	WNT1 inducible signaling pathway protein 2	10.9	Publications
11	KCNN4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	10.9	Publications
12	PTP4A2	protein tyrosine phosphatase type IVA, member 2	10.9	Publications
13	NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1	10.9	Publications
14	SPAM1	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	10.9	Publications
15	H19	H19, imprinted maternally expressed transcript (non-protein coding)	10.9	Publications
16	NPPC	natriuretic peptide C	10.9	Publications
17	LDHA	lactate dehydrogenase A	10.9	Publications
18	NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	10.9	Publications
19	ALDOA	aldolase A, fructose-bisphosphate	10.9	Publications
20	TUBA1B	tubulin, alpha 1b	10.9	Publications
21	CTSK	cathepsin K	10.9	Publications
22	PDHX	pyruvate dehydrogenase complex, component X	10.9	Publications
23	LIN28B	lin-28 homolog B (C. elegans)	10.9	Functions
24	LAMB1	laminin, beta 1	10.9	Publications
25	AREG	amphiregulin	10.9	Publications
26	CA9	carbonic anhydrase IX	10.9	Publications
27	ALDH1A1	aldehyde dehydrogenase 1 family, member A1	10.9	Publications
28	THBS1	thrombospondin 1	10.9	Publications
29	NQO1	NAD(P)H dehydrogenase, quinone 1	10.9	Publications
30	ALDH9A1	aldehyde dehydrogenase 9 family, member A1	10.9	Publications
31	CCNA2	cyclin A2	10.9	Publications
32	NEU1	sialidase 1 (lysosomal sialidase)	10.9	Publications
33	PTPN6	protein tyrosine phosphatase, non-receptor type 6	10.9	Publications
34	CXCR3	chemokine (C-X-C motif) receptor 3	10.9	Publications
35	SULF2	sulfatase 2	10.9	Publications
36	CTSD	cathepsin D	10.9	Publications
37	RHOD	ras homolog family member D	10.9	Publications
38	CASP7	caspase 7, apoptosis-related cysteine peptidase	10.9	Publications
39	AHR	aryl hydrocarbon receptor	10.9	Publications
40	TUBB	tubulin, beta class I	10.9	Publications
41	MMP14	matrix metallopeptidase 14 (membrane-inserted)	10.9	Publications
42	CHEK2	checkpoint kinase 2	10.9	Publications
43	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	10.9	Publications
44	ODC1	ornithine decarboxylase 1	10.9	Publications
45	CXCL10	chemokine (C-X-C motif) ligand 10	10.9	Publications
46	NPPA	natriuretic peptide A	10.9	Publications
47	NPPB	natriuretic peptide B	10.9	Publications
48	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	10.9	Publications
49	SST	somatostatin	10.9	Publications
50	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	10.9	Publications

Pathways related to breast adenocarcinoma according to GeneDecks:

(show top 50)    (show all 289)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer20	10.3	MAPK8, FOS, TGFBR2, TGFB1
2	Glioma Invasiveness36	10.3	BMP6, PLAUR, TIMP1, MDK, PLAU, AREG
3	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	9.7	CYCS, AKT1, MAPK3
4	Apoptosis and survival FAS signaling cascades10	9.7	BCL2, PARP1, CASP8, BAX, FAS, CYCS
5	Apoptosis and survival_FAS signaling cascades41	9.6	CASP7, PARP1, BCL2, BAX, FAS, MAPK8
6	Akt Signaling36	9.3	TNF, AKT1, IGF1R, MDK, TNFSF11, CXCL10
7	TNF-Induced Apoptosis Implicating Sphingolipids36	9.3	BAX, CTSD, MAPK8, MAPK1, CASP7, MAPK3
8	p53 signaling pathway20	9.2	THBS1, CYCS, SERPINE1, CHEK2, BAX, CDKN1A
9	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	9.2	BCL2, MAPK3, FOS, MAPK8, MAPK1, ESR1
10	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	9.2	BCL2, BAX, FOS, MAPK8, MAPK3, CYCS
11	p53 Signaling36	9.1	MAPK8, FOS, CDKN1A, BAX, CHEK2, CASP8
12	Apoptosis and survival_Caspase cascade41	9.1	IGF1R, FAS, BAX, PARP1, CASP7, CASP8
13	Apoptosis and survival Caspase cascade10	9.1	CYCS, CASP8, AKT1, CASP7, IGF1R, FAS
14	Ceramide Pathway36	9.0	FOS, MAPK8, MAPK3, CASP7, AKT1, TNF
15	UPA-UPAR Pathway36	8.9	MMP9, SERPINE1, LAMB1, MMP1, MMP2, FOS
16	Endothelin-1 Signaling Pathway36	8.8	BMP6, CASP7, MAPK3, MAPK1, IGF1R, TNFSF11
17	Chronic myeloid leukemia20	8.8	TGFB1, MAPK3, CDKN1A, MAPK1, CDKN1B, AKT1
18	Cell adhesion ECM remodeling10	8.8	IGF1R, PLAU, TIMP1, EGFR, PLAUR, SERPINE1
19	Cell adhesion_ECM remodeling41	8.8	MMP9, MMP2, MMP14, MMP1, LAMB1, SERPINE1
20	Selected targets of p5310	8.7	BCL2, THBS1, ABCB1, CTSD, BAX, CASP7
21	14-3-3 Induced Apoptosis36	8.7	MAPK8, CASP8, CASP7, MAPK1, MAPK3, CYCS
22	14-3-3 Induced Intracellular Signaling36	8.7	TIMP1, AREG, MDK, TGFB1, TNF, TP73
23	Rho Family GTPases36	8.7	MAPK1, BCL2, BAX, LAMB1, FOS, FN1
24	Development_ERBB-family signaling41	8.7	MAPK1, MAPK3, AREGB, FOS, AREG, EGFR
25	Apoptosis Signaling Pathways37	8.6	BAX, CYCS, FAS, TNF, TP53, CASP8
26	Osteoclast differentiation20	8.6	FOS, MAPK8, MAPK3, MAPK1, CTSK, TNF
27	Chagas disease (American trypanosomiasis)20	8.4	FOS, SERPINE1, TGFBR2, TGFB1, NFKBIA, TNF
28	PEDF Induced Signaling36	8.4	NFKBIA, MAPK1, CASP7, CASP8, AKT1, TNF
29	Development_EGFR signaling pathway41	8.4	MMP2, EGF, MAPK3, EGFR, MAPK8, AREG
30	MIF Regulation of Innate Immune Cells36	8.2	TNFSF11, NFKBIA, CSF1, FOS, CXCL10, TNF
31	DHA Signaling36	8.1	CYCS, AKT1, CASP8, CASP7, MDK, EGF
32	Glioblastoma Multiforme36	8.0	EGFR, AKT1, IGF1R, MAPK1, MAPK3, MGMT
33	ILK Signaling36	7.8	TIMP1, NACA, LAMB1, FOS, FN1, EGFR
34	TGF-Beta Pathway36	7.8	FOS, BAX, MDK, BCL2, BMP6, MAPK1
35	ERK Signaling36	7.7	TGFB1, MDK, MAPK3, BMP6, MAPK1, TIMP1
36	Bladder cancer20	7.7	THBS1, EGFR, EGF, TP53, CDKN1A, MMP9
37	PAK Pathway36	7.6	CXCL10, EGFR, MDK, MAPK8, IGF1R, CASP7
38	p53 Mediated Apoptosis36	7.6	CHEK2, TGFB1, AKT1, IGF1R, CASP8, TIMP1
39	Prostate cancer20	7.6	MAPK1, IGF1R, AKT1, TP53, NFKBIA, EGF
40	Mitochondrial Apoptosis36	7.6	CHEK2, BAX, AREG, MDK, IGF1R, CASP8
41	MAPK Family Pathway36	7.2	EGF, MDK, BCL2, MAPK8, MAPK3, HSPB1
42	Estrogen Pathway36	7.1	TGFB1, TIMP1, EGFR, EGF, SP1, AKT1
43	Apoptotic Pathways in Synovial Fibroblasts36	7.0	IGF1R, EGF, EGFR, MDK, AREG, CASP8
44	Antioxidant Action of Vitamin-C36	6.9	MAPK3, CSF1, CXCR3, CXCL10, TGFB1, TIMP1
45	Colorectal Cancer Metastasis36	6.9	TNF, MAPK1, MAPK3, MMP2, MMP9, MMP14
46	Cellular Apoptosis Pathway36	6.9	TP53, TNF, CYCS, NFKBIA, EGF, EGFR
47	p38 Signaling36	6.8	CXCL10, TGFB1, TIMP1, EGFR, HSPB1, SP1
48	Pancreatic Adenocarcinoma36	6.6	BMP6, MMP1, CDKN1B, CDKN1A, BCL2, MMP2
49	Molecular Mechanisms of Cancer36	6.2	MDK, AREG, FN1, FOS, CDKN1B, CDKN1A
50	Pathways in cancer20	5.7	CDKN1A, EGF, EGFR, TGFB1, TGFBR2, NFKBIA

Compounds related to breast adenocarcinoma according to GeneDecks:

(show top 50)    (show all 544)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.1	MAPK8, MAPK3, CYCS, ODC1, SP1, NFKBIA
2	phosphatidylserine32 9 9	11.9	PARP1, BCL2, CASP7, CASP8, CAV1, CYCS
3	h2o232	9.6	LEP, MAPK8, IGF1R, ALDH9A1, HMGCR, TUBA1B
4	gnrh32	9.5	SERPINE1, LEP, MKI67, AKT1, ODC1, SP1
5	phenethyl isothiocyanate32	9.2	PARP1, BCL2, BAX, GSTP1, MAPK8, MAPK1
6	heparin32 9 18 9	12.1	SERPINE1, CD36, FN1, AREG, MDK, MAPK3
7	4-hydroxynonenal32 18	10.0	PARP1, BAX, MMP1, FOS, GSTP1, FAS
8	ascorbic acid32 18	9.8	PCNA, CD36, MMP2, GSTP1, FAS, MAPK3
9	vinblastine32 9 9	10.8	BCL2, BAX, FN1, GSTP1, MAPK8, CCNA2
10	procollagen32	8.7	PCNA, BMP6, CD36, MMP1, MMP14, MMP2
11	vitamin e succinate32	8.7	BMP6, PARP1, BCL2, BAX, CDKN1A, FAS
12	arginine32	8.6	LEP, FN1, MAPK3, CCNA2, HSPB1, CASP8
13	aspirin32 34 18	10.5	PCNA, SERPINE1, BMP6, MMP1, MMP2, FN1
14	pge232	8.5	MMP1, FN1, IGF1R, CASP7, TNFSF11, SST
15	epinephrine32 9 18 9	11.3	BMP6, LEP, MMP1, MMP2, MMP9, AREG
16	ribonucleic acid32	8.3	BMP6, MMP1, MMP14, MMP2, MMP9, FOS
17	tetracycline32 9 9	10.1	RB1, MMP1, MMP14, MMP2, MMP9, FAS
18	forskolin32 42 9 9	11.1	BMP6, CDKN1B, MMP14, FOS, AREG, MAPK3
19	indole-3-carbinol32	8.1	PARP1, BCL2, BAX, CDKN1A, CDKN1B, CASP8
20	cyclosporin a32 42	9.1	LEP, MMP1, MMP9, FN1, CCNA2, HSPB1
21	cytarabine32 34 9 9	11.0	PCNA, RB1, BCL2, BAX, CDKN1A, CD36
22	topotecan32 9 9	10.0	PARP1, BCL2, MGMT, GSTP1, CCNA2, CASP7
23	thapsigargin32 42	8.8	PCNA, SERPINE1, BCL2, CD36, MAPK8, MAPK3
24	flavopiridol32 9 9	9.7	RB1, VEGFA, PARP1, BCL2, BAX, CDKN1A
25	glutamate32	7.6	PCNA, BMP6, LEP, CDKN1B, MMP2, MMP9
26	suramin32 9 9	9.6	PCNA, VEGFA, BMP6, FOS, MAPK3, MAPK1
27	rapamycin32 42	8.6	RB1, VEGFA, CHEK2, FN1, MAPK8, CCNA2
28	5-aza-2deoxycytidine32	7.6	PCNA, BMP6, CDKN1A, MGMT, GSTP1, FAS
29	oxaliplatin32 34 9 9	10.5	VEGFA, CDKN1A, MGMT, GSTP1, FAS, CCNA2
30	bortezomib32 9 9	9.5	VEGFA, PARP1, BCL2, BAX, CDKN1A, CDKN1B
31	oxygen32 18	8.4	RB1, PARP1, BCL2, CHEK2, LDHA, BAX
32	ag 147832	7.4	SERPINE1, CDKN1B, MMP14, MMP2, MMP9, FOS
33	tgf beta132	7.3	SERPINE1, BMP6, CDKN1A, CD36, CDKN1B, MMP1
34	alanine32	7.3	PCNA, BMP6, CHEK2, CDKN1B, MMP14, MMP2
35	tacrolimus32 34 9 9	10.1	PCNA, SERPINE1, BMP6, CD36, FN1, IGF1R
36	ly29400232	7.1	VEGFA, LEP, CDKN1B, MMP14, MMP2, MMP9
37	gefitinib32 34 9 9	9.7	VEGFA, CDKN1A, CDKN1B, MMP2, MMP9, AREG
38	cysteine32	6.7	PCNA, PARP1, MMP1, MMP2, MMP9, FN1
39	sb 20358032 42	7.6	RB1, VEGFA, BMP6, PARP1, BCL2, CDKN1A
40	etoposide32 42 9 9	9.3	PCNA, RB1, PARP1, BCL2, CHEK2, BAX
41	resveratrol32 9 18 9	9.2	PCNA, RB1, VEGFA, PARP1, BCL2, BAX
42	herbimycin a32 42	6.9	BMP6, CD36, MMP1, MMP14, MMP2, MMP9
43	testosterone32 9 18 9	8.8	PCNA, RB1, CDKN1B, MMP1, MMP2, MMP9
44	phosphatidylinositol32	5.3	RB1, BMP6, BCL2, LEP, CHEK2, BAX
45	doxorubicin32 34 9 9	7.9	BMP6, PARP1, CHEK2, CDKN1B, MMP1, FN1
46	5fluorouracil32	4.6	PCNA, RB1, VEGFA, BCL2, BAX, CDKN1A
47	tyrosine32	4.2	RB1, VEGFA, BMP6, CHEK2, LDHA, CDKN1A
48	cisplatin32 34 9 9	6.4	PCNA, RB1, VEGFA, BMP6, PARP1, BCL2
49	dexamethasone32 42 34 9 9	6.9	PCNA, RB1, SERPINE1, VEGFA, BMP6, PARP1
50	paclitaxel32 34 9 9	5.8	PCNA, RB1, VEGFA, BMP6, PARP1, BCL2

Cellular components related to breast adenocarcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.4	TGFB1, THBS1, TIMP1, EGF, ALDOA, FN1
2	proteinaceous extracellular matrix	GO:005578	9.2	ADAMTSL1, TGFB1, DSPP, FN1, MMP9, MMP2
3	external side of plasma membrane	GO:009897	8.9	CXCR3, CXCL10, TGFBR2, THBS1, TNF, FAS
4	cell surface	GO:009986	8.3	PLAU, PLAUR, ABCB1, TGFB1, WISP2, SULF2
5	extracellular region	GO:005576	7.8	TIMP1, EGF, C1RL, PLAUR, PLAU, THBS1
6	nucleoplasm	GO:005654	7.2	MAPK1, CCNA2, CASP7, AKT1, ESR1, TP53
7	cytosol	GO:005829	7.0	TUBB, AKT1, CAV1, CASP8, CASP7, TP53
8	extracellular space	GO:005615	6.6	WISP2, CTSK, PLAU, EGF, EGFR, THBS1
9	plasma membrane	GO:005886	5.1	EGFR, EGF, RHOD, NFKBIA, PKM, PLAUR
10	nucleus	GO:005634	4.1	CYCS, PTPN6, TP73, TP53, ESR1, AKT1

Biological processes related to breast adenocarcinoma according to GeneDecks:

(show top 50)    (show all 66)

id	Name	GO ID	Score	Top Affiliating Genes
1	cGMP biosynthetic process	GO:006182	10.7	NPR1, NPPC, NPPB, NPPA
2	regulation of blood vessel size	GO:050880	10.7	NPR1, NPPC, NPPB, NPPA
3	receptor guanylyl cyclase signaling pathway	GO:007168	10.7	NPR1, NPPC, NPPB, NPPA
4	caveolin-mediated endocytosis	GO:072584	10.2	CAV1, MAPK1, MAPK3
5	kidney development	GO:001822	10.2	ODC1, SULF2, TP73, ALDH9A1, BAX, BMP6
6	extracellular matrix disassembly	GO:022617	10.2	TIMP1, MMP9, MMP2, MMP14, MMP1
7	positive regulation of cellular protein metabolic process	GO:032270	10.2	CSF1, TGFB1, NFKBIA, AKT1
8	response to toxin	GO:009636	10.0	NQO1, FAS, MGMT, CDKN1A, BAX, BCL2
9	macrophage differentiation	GO:030225	10.0	CSF1, CASP8, MMP9, VEGFA
10	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	10.0	MAPK1, MAPK3, MAPK8, FOS
11	aging	GO:007568	10.0	TGFB1, TIMP1, HMGCR, CASP7, ALDH3A1, FAS
12	release of cytochrome c from mitochondria	GO:001836	9.9	BCL2, BAX, CASP7, TP53, TP73
13	positive regulation of blood vessel endothelial cell migration	GO:043536	9.9	TGFB1, THBS1, AKT1, VEGFA
14	response to gamma radiation	GO:010332	9.9	CXCL10, TP53, CAV1, BAX, CHEK2, BCL2
15	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.8	TGFBR2, THBS1, TP53, CD36, CDKN1A
16	activation of pro-apoptotic gene products	GO:008633	9.8	AKT1, CASP8, MAPK8, FAS, BAX, BCL2
17	regulation of blood pressure	GO:008217	9.8	NPR1, NPPC, NPPB, NPPA, LEP
18	neuron apoptotic process	GO:051402	9.8	TP53, FAS, BAX, BCL2, RB1
19	transformed cell apoptotic process	GO:006927	9.7	BAX, FAS, TNF
20	Ras protein signal transduction	GO:007265	9.6	TP53, CCNA2, MAPK1, MAPK3, CDKN1A, RB1
21	cell cycle arrest	GO:007050	9.6	TGFB1, THBS1, TP73, TP53, CDKN1B, CDKN1A
22	negative regulation of cell growth	GO:030308	9.5	NPR1, NPPB, NPPA, TGFB1, TP53, CDKN1B
23	transforming growth factor beta receptor signaling pathway	GO:007179	9.5	TGFBR2, TGFB1, SP1, TP53, FOS, PARP1
24	innate immune response	GO:045087	9.5	CSF1, C1RL, NFKBIA, CTSK, CASP8, MAPK1
25	response to DNA damage stimulus	GO:006974	9.4	TP73, TP53, MAPK3, CDKN1A, BAX, CHEK2
26	platelet degranulation	GO:002576	9.4	TGFB1, THBS1, TIMP1, EGF, ALDOA, FN1
27	angiogenesis	GO:001525	9.3	CXCR3, EGF, CASP8, HSPB1, FN1, MMP2
28	response to estrogen stimulus	GO:043627	9.3	ESR1, CAV1, FAS, BCL2, SERPINE1
29	induction of apoptosis by intracellular signals	GO:008629	9.2	CYCS, TP53, AKT1, CASP8, CASP7, MAPK8
30	ossification	GO:001503	9.2	NPPC, CSF1, DSPP, EGFR, SP1, TNFSF11
31	protein import into nucleus, translocation	GO:000060	9.2	TGFB1, NFKBIA, TNF, TP53, AKT1
32	virus-host interaction	GO:019048	9.1	TGFB1, NFKBIA, SP1, TP53, CAV1, CASP8
33	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.1	TGFB1, TNF, AKT1, CAV1, BCL2, VEGFA
34	positive regulation of cell migration	GO:030335	9.0	CSF1, TGFB1, THBS1, EGFR, IGF1R, MMP14
35	anti-apoptosis	GO:006916	8.9	THBS1, NFKBIA, TNF, AKT1, HSPB1, IGF1R
36	inflammatory response	GO:006954	8.8	NPPB, CSF1, CXCL10, TGFB1, TNF, TP73
37	epidermal growth factor receptor signaling pathway	GO:007173	8.8	TGFB1, EGFR, EGF, AKT1, MAPK1, MAPK3
38	platelet activation	GO:030168	8.7	AKT1, EGF, TIMP1, THBS1, TGFB1, ALDOA
39	response to hypoxia	GO:001666	8.7	TNF, THBS1, TGFB1, NPPB, NPPC, CAV1
40	MAPK cascade	GO:000165	8.7	TGFB1, EGFR, TNF, CAV1, MAPK1, MAPK3
41	positive regulation of protein kinase B signaling cascade	GO:051897	8.6	TNF, TNFSF11, EGFR, THBS1, TGFB1
42	positive regulation of MAP kinase activity	GO:043406	8.4	TGFB1, EGFR, EGF, TNFSF11, TNF, VEGFA
43	small molecule metabolic process	GO:044281	8.4	CYCS, ODC1, NQO1, PKM, PDHX, ABCB1
44	response to drug	GO:042493	8.3	ABCB1, ABCG2, THBS1, TGFB1, TGFBR2, NPPB
45	positive regulation of transcription, DNA-dependent	GO:045893	8.3	EGF, SP1, TNF, TP73, TP53, CCNA2
46	positive regulation of cell proliferation	GO:008284	8.2	EGFR, TIMP1, TGFB1, TGFBR2, CXCL10, CSF1
47	apoptotic process	GO:006915	7.9	TP53, TNF, PTPN6, CYCS, NFKBIA, AHR
48	blood coagulation	GO:007596	7.7	TP53, PTPN6, PLAU, PLAUR, EGF, TIMP1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.3	TGFB1, NFKBIA, SP1, TNFSF11, TNF, TP73
50	negative regulation of apoptotic process	GO:043066	6.6	SERPINE1, THBS1, TIMP1, EGFR, PLAUR, TNF

Molecular functions related to breast adenocarcinoma according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	peptide hormone receptor binding	GO:051428	10.1	NPPC, NPPB, NPPA, LEP
2	transcription factor binding	GO:008134	9.3	RB1, PARP1, BCL2, TP53, TP73, SP1
3	growth factor activity	GO:008083	8.9	CSF1, TGFB1, EGF, MDK, AREGB, LEP
4	nitric-oxide synthase regulator activity	GO:030235	8.6	EGFR, ESR1, AKT1
5	enzyme binding	GO:019899	7.7	PGR, TGFB1, EGFR, NFKBIA, PLAUR, TP53
6	identical protein binding	GO:042802	6.5	TP53, TP73, TNF, NFKBIA, EGFR, THBS1
7	protein binding	GO:005515	1.1	GGT1, NQO1, SP1, CYCS, PTPN6, TNF