MCID: BRS044
MIFTS: 46

Breast Adenocarcinoma malady

Summaries for Breast Adenocarcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An adenocarcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast.

MalaCards: Breast Adenocarcinoma, also known as mammary adenocarcinoma, is related to adenocarcinoma and breast cancer. An important gene associated with Breast Adenocarcinoma is CST9 (cystatin 9 (testatin)), and among its related pathways is PAK Pathway. The compounds estrogen and 8-bromo cgmp have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and colon, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Classifications for Breast Adenocarcinoma

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Sources:
8Disease Ontology, 60UMLS, 39NCIt
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Aliases & Descriptions:

breast adenocarcinoma 8 60
mammary adenocarcinoma 8


External Ids:

Disease Ontology8 DOID:3458
NCIt39 C5214

Related Diseases for Breast Adenocarcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Breast Adenocarcinoma family:

Rare Adenocarcinoma of the Breast

Diseases related to Breast Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.7ALDH3A1, CCNA2, CA9, NPR1, NPPC, MDK
2breast cancer30.4MDK, CTSK, WISP2, CA9, CCNA2, AREGB
3colon adenocarcinoma30.2CCNA2, NPR1, NPPC, AREG
4sarcoma30.2CA9, CCNA2
5colorectal cancer29.9CA9, AREGB, AREG, PTPN6
6prostate cancer29.9CCNA2, CA9, CTSK, AREG, CXCL10, PTPN6
7cervical cancer29.9AREG, CA9, CCNA2
8breast disease10.2
9breast sarcoma10.2
10mucinous adenocarcinoma10.1
11breast squamous cell carcinoma10.1
12cervical adenocarcinoma10.1
13cervicitis10.1
14leukemia10.1
15prostate adenocarcinoma10.1
16prostatitis10.1
17squamous cell carcinoma10.1
18vulva adenocarcinoma10.1
19adenocarcinoma in situ10.0
20adenoma10.0
21pituitary adenoma10.0
22colon cancer10.0AREG, CCNA2
23cutaneous t cell lymphoma10.0PTPN6, CXCL10, CXCR3
24ovarian cancer10.0CCNA2, CA9, AREG, PTPN6
25bladder carcinoma10.0CA9, AREG, CXCL10, SPAM1
26acromesomelic dysplasia10.0NPPC
27hepatocellular carcinoma10.0CCNA2, MDK, AREG, ALDH3A1
28rheumatoid arthritis10.0KCNN4, CTSK, AREG, CXCR3, CXCL10
29pancreatic cancer10.0AREG, CA9, CCNA2
30myeloma10.0AREG, CTSK, CCNA2
31asthma10.0CCNA2, NPPC, AREG, CXCR3, CXCL10
32allergic contact dermatitis10.0CXCL10, CXCR3
33pulmonary disease, chronic obstructive10.0AREG, CXCR3, CXCL10
34pulmonary fibrosis10.0CXCR3, CTSK
35periapical granuloma10.0CXCR3
36kidney cancer10.0CA9, NPR1, NPPC, CXCR3
37burkitt's lymphoma10.0PTPN6, CXCR3, CCNA2
38lung cancer10.0CCNA2, CA9, CTSK, AREG, CXCR3
39male breast cancer9.9
40bone carcinoma9.9
41breast fibrosarcoma9.9
42hereditary multiple exostoses9.9
43malignant breast melanoma9.9
44signet ring cell adenocarcinoma9.9
45breast signet ring cell adenocarcinoma9.9
46cauda equina syndrome9.9
47breast lymphoma9.9
48apocrine adenocarcinoma9.9
49breast papillomatosis9.9
50cervical squamous cell carcinoma9.9

Graphical network of the top 20 diseases related to Breast Adenocarcinoma:



Diseases related to breast adenocarcinoma

Clinical Features for Breast Adenocarcinoma

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Drugs & Therapeutics for Breast Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Breast Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Breast Adenocarcinoma

Search NIH Clinical Center for Breast Adenocarcinoma

Search CenterWatch for Breast Adenocarcinoma

Genetic Tests for Breast Adenocarcinoma

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Anatomical Context for Breast Adenocarcinoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Breast Adenocarcinoma:

32
Breast, Lung, Colon, Prostate, Brain, T cells, Liver, Testes, B cells, Bone, Endothelial, Lymph node, Whole blood, Monocytes, Cervix, Spinal cord, Pancreas, Placenta, Ovary, Skin, Thyroid, Salivary gland

Animal Models for Breast Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Breast Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.4CA9, NPR1, NPPC, CTSK, AREG, PTPN6
2MP:000538710.1PTPN6, KCNN4, CCNA2, NPR1, CTSK, MDK

Publications for Breast Adenocarcinoma

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Sources:
50PubMed
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Articles related to Breast Adenocarcinoma:

(show top 50)    (show all 302)
idTitleAuthorsYear
1
XIAP inhibitor and antiestrogen embelin abrogates metastasis and augments apoptosis in estrogen receptor positive human breast adenocarcinoma cell line MCF-7. (24390234)
2014
2
Bilateral breast metastasis from mucinous adenocarcinoma of the rectum: a case report and review of the literature. (24022315)
2013
3
Extracellular matrix heterogeneity regulates three-dimensional morphologies of breast adenocarcinoma cell invasion. (23184641)
2013
4
Part I. Molecular and cellular characterization of high nitric oxide-adapted human breast adenocarcinoma cell lines. (23238815)
2013
5
Administration of the optimized I^-Lapachone-poloxamer-cyclodextrin ternary system induces apoptosis, DNA damage and reduces tumor growth in a human breast adenocarcinoma xenograft mouse model. (23333901)
2013
6
Primary breast adenocarcinoma in ectopic breast tissue in the vulva. (24066246)
2013
7
Brain tumor imaging: imaging brain metastasis using a brain-metastasizing breast adenocarcinoma. (23457349)
2013
8
Procyanidin b2 cytotoxicity to mcf-7 human breast adenocarcinoma cells. (23626391)
2012
9
Cutaneous metastasis of signet-ring gastric adenocarcinoma to the breast with unusual clinicopathological features. (21737667)
2011
10
Volatile oil composition and antiproliferative activity of Laurus nobilis, Origanum syriacum, Origanum vulgare, and Salvia triloba against human breast adenocarcinoma cells. (20534330)
2010
11
Anticancer effect of a novel 2-arylidene-4,7-dimethyl indan-1-one against human breast adenocarcinoma cell line by G2/M cell cycle arrest. (20681405)
2010
12
alpha-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells. (20492173)
2010
13
Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells. (18695915)
2008
14
Novel synthetic triterpenoid methyl 25-hydroxy-3-oxoolean-12-en-28-oate induces apoptosis through JNK and p38 MAPK pathways in human breast adenocarcinoma MCF-7 cells. (18058803)
2008
15
CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells. (18794149)
2008
16
Plasminogen activator inhibitor type 1 is the most significant of the usual tissue prognostic factors in node-negative breast ductal adenocarcinoma independent of urokinase-type plasminogen activator. (18621614)
2008
17
Mucosal vaccination with phage-displayed tumour antigens identified through proteomics-based strategy inhibits the growth and metastasis of 4T1 breast adenocarcinoma. (18097564)
2008
18
Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets. (17363502)
2007
19
Differential effects of quercetin and silymarin on arsenite-induced cytotoxicity in two human breast adenocarcinoma cell lines. (17931660)
2007
20
Antitumor activity of capecitabine and bevacizumab combination in a human estrogen receptor-negative breast adenocarcinoma xenograft model. (17695515)
2007
21
Breast adenocarcinoma metastatic to epidural cervical spine meningioma: case report and review of the literature. (16132512)
2005
22
Casuarinin from the bark of Terminalia arjuna induces apoptosis and cell cycle arrest in human breast adenocarcinoma MCF-7 cells. (15770544)
2005
23
Inhibition of breast adenocarcinoma growth by intratumoral injection of lipophilic long-acting lathyrogens. (15655419)
2005
24
Calcified metastatic mediastinal lymph nodes from mucinous breast adenocarcinoma. (14566424)
2004
25
Vulvar Paget's disease with underlying adenocarcinoma simulating breast carcinoma: case report and review of the literature. (15361217)
2004
26
Effect of pH on uptake and photodynamic action of chlorin p6 on human colon and breast adenocarcinoma cell lines. (14872242)
2004
27
Breast adenocarcinoma cell adhesion to the vascular subendothelium in whole blood and under flow conditions: effects of alphavbeta3 and alphaIIbbeta3 antagonists. (15679053)
2004
28
Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. (15158999)
2004
29
Metastatic breast adenocarcinoma masquerading as colonic primary. Report of two cases. (15655598)
2004
30
Mucinous adenocarcinoma of ectopic breast tissue of the vulva. (12296762)
2002
31
Rb localization and phosphorylation kinetics correlate with the cellular phenotype of cultured breast adenocarcinoma cells. (12197776)
2002
32
Tissue lipid peroxidation and antioxidant status in patients with adenocarcinoma of the breast. (12367782)
2002
33
Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5'-upstream regions of these genes. (11306049)
2001
34
Genetic instability promotes the acquisition of chromosomal imbalances in T1b and T1c breast adenocarcinomas. (11455031)
2001
35
Isolation and characterization of human breast adenocarcinoma cells made resistant to alpha-difluoromethylornithine. (10705873)
2000
36
Paget's disease of the vulva associated with local adenocarcinoma and previous breast adenocarcinoma: report of two cases. (10417532)
1999
37
Involvement of p21 in mitotic exit after paclitaxel treatment in MCF-7 breast adenocarcinoma cell line. (9419978)
1997
38
Intense uptake of technetium-99m-MDP in primary breast adenocarcinoma with sarcomatoid metaplasia. (9098196)
1997
39
Generalized cutaneous metastases from breast adenocarcinoma. (9216540)
1997
40
Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells. (8754775)
1996
41
Early gene responses associated with transforming growth factor-beta 1 growth inhibition and autoinduction in MCF-7 breast adenocarcinoma cells. (7766715)
1995
42
Analysis of the complete sequence of the novel metastasis-associated candidate gene, mta1, differentially expressed in mammary adenocarcinoma and breast cancer cell lines. (7607577)
1995
43
Identification of the class-3 aldehyde dehydrogenases present in human MCF-7/0 breast adenocarcinoma cells and normal human breast tissue. (8068047)
1994
44
Serum transferrin receptor level is not altered in invasive adenocarcinoma of the breast. (8447283)
1993
45
Adenocarcinoma in the lung in patients with breast cancer. A prospective analysis of the discriminatory value of immunohistology. (8346734)
1993
46
Amplification of the c-erb B-2 oncogene and prognosis of breast adenocarcinoma. (1967929)
1990
47
Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. (3413110)
1988
48
Effects of three new folate antagonists on human breast adenocarcinoma cells in vitro and on immune responses in vivo. (6692721)
1984
49
Seborrheic keratosis and papillomatosis: markers of breast adenocarcinoma. (6225626)
1983
50
CO-EXISTENT CYSTOSARCOMA PHYLLODES AND SCIRRHOUS ADENOCARCINOMA OF THE BREAST. (14080403)
1963

Genetic Variations for Breast Adenocarcinoma

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Expression for genes affiliated with Breast Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Adenocarcinoma

Search GEO for disease gene expression data for Breast Adenocarcinoma.

Pathways for genes affiliated with Breast Adenocarcinoma

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51QIAGEN
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Pathways related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4PTPN6, CXCL10, CXCR3, AREG, MDK

Compounds for genes affiliated with Breast Adenocarcinoma

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8WISP2
28-bromo cgmp4410.8CCNA2, NPR1, NPPC
3thymidine44 2411.8PTPN6, KCNN4, CCNA2, NPPC, AREG, CXCR3
4forskolin44 49 1112.8CCNA2, NPR1, NPPC, AREG, CXCL10
5retinoic acid44 2411.8CCNA2, NPPC, CTSK, MDK, AREG, CXCL10
6heparan sulfate44 2411.8MDK, AREG, CXCR3, CXCL10
7tetraethylammonium44 28 1112.8KCNN4, KCNA3, NPPC
8cl-4as-15910.8AREG, AREGB
9progesterone44 59 28 11 2414.8CCNA2, CA9, WISP2, AREG, CXCR3, CXCL10
10serine4410.8C1RL, CCNA2, NPR1, NPPC, CTSK, AREG
11nitric oxide44 11 2412.8CCNA2, NPR1, NPPC, CXCR3, CXCL10, PTPN6
12calcium44 49 11 2413.8KCNN4, CCNA2, CA9, NPPC, CTSK, AREG
13vegf4410.8CCNA2, CA9, AREG, CXCR3, CXCL10, PTPN6
14chloride4410.8KCNN4, CA9, NPPC, CTSK
15urodilatin4410.7NPPC, NPR1
16iudr4410.7CA9, CCNA2
17tyrosine4410.7CCNA2, CA9, NPPC, CTSK, AREG, CXCR3
18lipid4410.7CCNA2, NPPC, MDK, CXCL10, PTPN6, SPAM1
19heparin44 28 11 2413.7WISP2, AREG, CXCR3
20iberiotoxin44 59 2812.7NPPC, KCNN4
21nilutamide44 59 28 1113.7AREG, AREGB
22mitomycin c4410.6CA9, AREG, ALDH3A1
23histamine44 28 2412.6CXCL10, CXCR3, NPPC, KCNN4
24charybdotoxin44 2811.6KCNA3, KCNN4
25glycosaminoglycan4410.5AREG, CXCL10, SPAM1
26sodium nitroprusside4410.5CXCR3, NPPC, NPR1
27genistein44 28 59 2 11 2415.5PTPN6, CXCL10, NPPC, CCNA2
28phorbol4410.4PTPN6, NPPC, CCNA2
29dexamethasone44 49 28 1113.2CCNA2, NPPC, AREG

GO Terms for genes affiliated with Breast Adenocarcinoma

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16Gene Ontology
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Cellular components related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4CXCL10, AREGB, CTSK, NPPC, WISP2, C1RL

Biological processes related to Breast Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cGMP biosynthetic processGO:03082810.5NPPC, NPR1
2regulation of blood vessel sizeGO:05088010.5NPPC, NPR1
3cGMP biosynthetic processGO:00618210.4NPPC, NPR1
4receptor guanylyl cyclase signaling pathwayGO:00716810.2NPPC, NPR1

Products for genes affiliated with Breast Adenocarcinoma

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Sources for Breast Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet