Aliases & Classifications for Breast Adenoid Cystic Carcinoma

MalaCards integrated aliases for Breast Adenoid Cystic Carcinoma:

Name: Breast Adenoid Cystic Carcinoma 12 14
Adenoid Cystic Carcinoma of Breast 12
Adenoid Cystic Breast Carcinoma 69
Mammary Adenocystic Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4877
NCIt 46 C5130
UMLS 69 C1332167

Summaries for Breast Adenoid Cystic Carcinoma

MalaCards based summary : Breast Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of breast, is related to adenoiditis and malignant mixed mullerian tumor, and has symptoms including pain An important gene associated with Breast Adenoid Cystic Carcinoma is NFIB (Nuclear Factor I B), and among its related pathways/superpathways are Gene Expression and Pathways in cancer. Affiliated tissues include breast, and related phenotypes are Decreased viability in esophageal squamous lineage and Decreased viability with paclitaxel

Related Diseases for Breast Adenoid Cystic Carcinoma

Diseases related to Breast Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 adenoiditis 10.4
2 malignant mixed mullerian tumor 10.3 KIT PGR
3 benign breast phyllodes tumor 10.3 KIT PGR
4 vulvar syringoma 10.3 ESR1 PGR
5 vestibular gland benign neoplasm 10.3 ESR1 PGR
6 lung leiomyoma 10.3 ESR1 PGR
7 bartholin's gland adenoma 10.3 ESR1 PGR
8 vulvar benign neoplasm 10.3 ESR1 PGR
9 breast angiosarcoma 10.3 KIT PGR
10 trigonitis 10.3 ESR1 PGR
11 vulvar leiomyoma 10.3 ESR1 PGR
12 cystic nephroma 10.3 KIT PGR
13 predominantly cortical thymoma 10.3 ESR1 PGR
14 progesterone resistance 10.3 ESR1 PGR
15 bartholin's gland benign neoplasm 10.3 ESR1 PGR
16 gastric signet ring cell adenocarcinoma 10.3 ESR1 PGR
17 endometrial mucinous adenocarcinoma 10.3 ESR1 PGR
18 perivascular epithelioid cell tumor 10.3 KIT PGR
19 deep angioma 10.3 ESR1 PGR
20 scirrhous adenocarcinoma 10.3 ERBB2 PGR
21 breast apocrine carcinoma 10.3 ERBB2 PGR
22 cervical carcinosarcoma 10.3 ESR1 PGR
23 synchronous bilateral breast carcinoma 10.3 ESR1 PGR
24 intramuscular hemangioma 10.3 ESR1 PGR
25 estrogen excess 10.3 ESR1 PGR
26 glycogen-rich clear cell breast carcinoma 10.3 ESR1 PGR
27 mammographic density 10.3 ESR1 PGR
28 retinitis pigmentosa 47 10.3 ESR1 PGR
29 adenomyosis 10.2 ESR1 PGR
30 retinitis pigmentosa 20 10.2 ESR1 PGR
31 dermoid cyst 10.2 KIT PGR
32 cervical clear cell adenocarcinoma 10.2 ESR1 PGR
33 endometriosis of ovary 10.2 ESR1 PGR
34 polymorphous low-grade adenocarcinoma 10.2 KIT NFIB
35 comedo carcinoma 10.2 ERBB2 ESR1
36 reproductive organ benign neoplasm 10.2 ESR1 PGR
37 dysgerminoma of ovary 10.2 KIT PGR
38 uterine benign neoplasm 10.2 ESR1 PGR
39 corneal abscess 10.1 AR PGR
40 pancreatic mucinous cystadenoma 10.1 ESR1 PGR
41 prostatic acinar adenocarcinoma 10.1 AR KIT
42 ewing's family of tumors 10.1 ERBB2 KIT
43 postmenopausal atrophic vaginitis 10.1 AR ESR1
44 breast secretory carcinoma 10.1 ERBB2 PGR
45 lobular neoplasia 10.1 ERBB2 ESR1
46 endometritis 10.1 ESR1 PGR
47 cribriform carcinoma 10.0 ESR1 KIT PGR
48 adenoid basal cell carcinoma 10.0 ESR1 KIT PGR
49 adenosarcoma 10.0 ESR1 KIT PGR
50 smooth muscle tumor 10.0 ESR1 KIT PGR

Graphical network of the top 20 diseases related to Breast Adenoid Cystic Carcinoma:



Diseases related to Breast Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Breast Adenoid Cystic Carcinoma

UMLS symptoms related to Breast Adenoid Cystic Carcinoma:


pain

GenomeRNAi Phenotypes related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.7 ACTN1 ERBB2 ESR1 KIT MYBL1 NFIB
2 Decreased viability with paclitaxel GR00179-A-1 9.13 EGFR ERBB2
3 Decreased viability with paclitaxel GR00179-A-3 9.13 EGFR
4 Increased cell viability after pRB stimulation GR00230-A-1 8.8 EGFR ERBB2 KIT

MGI Mouse Phenotypes related to Breast Adenoid Cystic Carcinoma:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.08 KIT ERBB2 AR ESR1 EGFR MYBL1
2 homeostasis/metabolism MP:0005376 10.06 EGFR ERBB2 AR ESR1 PGR KIT
3 digestive/alimentary MP:0005381 9.99 ERBB2 AR ESR1 EGFR KIT NFIB
4 integument MP:0010771 9.98 KIT ERBB2 AR ESR1 EGFR MYBL1
5 embryo MP:0005380 9.97 EGFR ERBB2 AR ESR1 PGR KIT
6 craniofacial MP:0005382 9.92 EGFR ERBB2 AR KIT NFIB
7 limbs/digits/tail MP:0005371 9.88 KIT ERBB2 AR ESR1 EGFR PGR
8 muscle MP:0005369 9.85 ERBB2 AR ESR1 EGFR PGR KIT
9 neoplasm MP:0002006 9.8 KIT ERBB2 AR ESR1 EGFR PGR
10 normal MP:0002873 9.7 KIT ERBB2 AR ESR1 EGFR MYBL1
11 no phenotypic analysis MP:0003012 9.65 EGFR ACTN1 ESR1 PGR KIT
12 reproductive system MP:0005389 9.5 KIT ERBB2 AR ESR1 EGFR MYBL1
13 skeleton MP:0005390 9.1 EGFR ERBB2 AR ESR1 PGR KIT

Drugs & Therapeutics for Breast Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Adenoid Cystic Carcinoma

Genetic Tests for Breast Adenoid Cystic Carcinoma

Anatomical Context for Breast Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Breast Adenoid Cystic Carcinoma:

38
Breast

Publications for Breast Adenoid Cystic Carcinoma

Articles related to Breast Adenoid Cystic Carcinoma:

# Title Authors Year
1
Discordant correlation of breast adenoid cystic carcinoma on imaging and pathology: A case report and literature review on surgical management. ( 29268125 )
2018
2
Breast adenoid cystic carcinoma: report of a case with emphasis on routine sonographic findings and shear wave elastography. ( 28382475 )
2017
3
Breast Adenoid Cystic Carcinoma: A Rare Case Report and Review of the Literature. ( 28798006 )
2017
4
MYB Labeling by Immunohistochemistry Is More Sensitive and Specific for Breast Adenoid Cystic Carcinoma than MYB Labeling by FISH. ( 28498281 )
2017
5
Cutaneous Metastasis of Breast Adenoid Cystic Carcinoma to the Scalp. ( 26968987 )
2016
6
18F-FDG PET/CT Imaging of Bilateral Renal Metastasis of Breast Adenoid Cystic Carcinoma. ( 26562575 )
2015
7
Breast adenoid cystic carcinoma in a 19-year-old man: a case report and review of the literature. ( 25885366 )
2015
8
Male breast adenoid cystic carcinoma. ( 24403896 )
2013
9
Clinical review--breast adenoid cystic carcinoma. ( 22154460 )
2012

Variations for Breast Adenoid Cystic Carcinoma

Cosmic variations for Breast Adenoid Cystic Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM25159 PTEN breast,NS,carcinoma,adenoid cystic carcinoma c.254-3C>T p.? 12
2 COSM27376 PIK3CA breast,NS,carcinoma,adenoid cystic carcinoma c.93A>G p.I31M 12
3 COSM476 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1799T>A p.V600E 12
4 COSM467 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1781A>G p.D594G 12
5 COSM449 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1391G>A p.G464E 12

Expression for Breast Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Breast Adenoid Cystic Carcinoma.

Pathways for Breast Adenoid Cystic Carcinoma

Pathways related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.36 AR EGFR ERBB2 ESR1 KIT MYBL1
2 12.49 AR EGFR ERBB2 ESR1 KIT
3
Show member pathways
12.22 EGFR ERBB2 ESR1 KIT PGR
4
Show member pathways
12.07 EGFR ERBB2 ESR1
5 12.03 EGFR ERBB2 ESR1
6 11.89 AR EGFR ESR1
7
Show member pathways
11.85 AR EGFR ERBB2
8 11.84 EGFR ERBB2 KIT
9
Show member pathways
11.61 AR ESR1 PGR
10 11.49 ACTN1 EGFR ERBB2
11 11.43 ERBB2 MYBL1 NFIB
12 11.39 EGFR ERBB2 KIT
13
Show member pathways
11.29 EGFR ERBB2 ESR1 PGR
14
Show member pathways
11.1 AR ESR1 NFIB
15 11.09 EGFR TOP2A
16 11.05 EGFR ERBB2
17 11.01 EGFR ERBB2
18
Show member pathways
10.89 EGFR ERBB2 ESR1 KIT

GO Terms for Breast Adenoid Cystic Carcinoma

Cellular components related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 8.92 AR EGFR ESR1 TOP2A

Biological processes related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.92 AR EGFR ESR1 MYBL1
2 protein autophosphorylation GO:0046777 9.76 EGFR ERBB2 KIT
3 transcription initiation from RNA polymerase II promoter GO:0006367 9.75 AR ESR1 PGR
4 peptidyl-tyrosine phosphorylation GO:0018108 9.74 EGFR ERBB2 KIT
5 positive regulation of protein kinase B signaling GO:0051897 9.73 EGFR ERBB2 KIT
6 regulation of transcription by RNA polymerase II GO:0006357 9.72 AR EGFR ERBB2 ESR1 KIT
7 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.7 EGFR ERBB2 KIT
8 male gonad development GO:0008584 9.67 AR ESR1 KIT
9 cellular response to estradiol stimulus GO:0071392 9.63 EGFR ESR1
10 phosphatidylinositol phosphorylation GO:0046854 9.63 EGFR ERBB2 KIT
11 stem cell differentiation GO:0048863 9.62 ESR1 KIT
12 positive regulation of phosphorylation GO:0042327 9.61 AR EGFR
13 regulation of cell motility GO:2000145 9.61 EGFR ERBB2
14 regulation of ERK1 and ERK2 cascade GO:0070372 9.6 EGFR ERBB2
15 positive regulation of MAP kinase activity GO:0043406 9.58 EGFR ERBB2 KIT
16 mammary gland alveolus development GO:0060749 9.55 AR ESR1
17 negative regulation of ERBB signaling pathway GO:1901185 9.54 EGFR ERBB2
18 steroid hormone mediated signaling pathway GO:0043401 9.54 AR ESR1 PGR
19 tongue development GO:0043586 9.51 EGFR KIT
20 positive regulation of transcription by RNA polymerase III GO:0045945 9.48 AR ERBB2
21 positive regulation of phospholipase C activity GO:0010863 9.43 ESR1 KIT
22 signal transduction by protein phosphorylation GO:0023014 9.33 EGFR ERBB2 KIT
23 morphogenesis of an epithelial fold GO:0060571 9.26 AR EGFR
24 positive regulation of transcription by RNA polymerase II GO:0045944 9.17 AR EGFR ESR1 MYBL1 NFIB PGR
25 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.96 AR PGR
26 signal transduction GO:0007165 10.07 AR EGFR ERBB2 ESR1 KIT PGR

Molecular functions related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.83 AR EGFR ESR1 TOP2A
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.72 AR ESR1 MYBL1 NFIB PGR
3 protein tyrosine kinase activity GO:0004713 9.71 EGFR ERBB2 KIT
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.69 EGFR ERBB2 KIT
5 ATPase binding GO:0051117 9.67 AR ESR1 PGR
6 enzyme binding GO:0019899 9.65 AR EGFR ESR1 PGR TOP2A
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.63 EGFR ERBB2 KIT
8 steroid hormone receptor activity GO:0003707 9.61 AR ESR1 PGR
9 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.58 EGFR ERBB2 KIT
10 nuclear receptor activity GO:0004879 9.54 AR ESR1 PGR
11 nitric-oxide synthase regulator activity GO:0030235 9.48 EGFR ESR1
12 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.35 AR ESR1 MYBL1 NFIB PGR
13 steroid binding GO:0005496 9.33 AR ESR1 PGR
14 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.8 EGFR ERBB2 KIT
15 DNA binding GO:0003677 10.02 AR ESR1 MYBL1 NFIB PGR TOP2A

Sources for Breast Adenoid Cystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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