MCID: BRS046
MIFTS: 26

Breast Benign Neoplasm

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Genetic diseases

Aliases & Classifications for Breast Benign Neoplasm

MalaCards integrated aliases for Breast Benign Neoplasm:

Name: Breast Benign Neoplasm 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0060082
ICD10 32 D24

Summaries for Breast Benign Neoplasm

MalaCards based summary : Breast Benign Neoplasm is related to breast fibroadenoma and vulvar syringoma. An important gene associated with Breast Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Thyroid hormone signaling pathway and Signaling by ERBB4. Affiliated tissues include breast, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Breast Benign Neoplasm

Diseases in the Breast Cancer family:

Breast Benign Neoplasm Inflammatory Breast Carcinoma
Sporadic Breast Cancer Breast Carcinoma in Situ

Diseases related to Breast Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 breast fibroadenoma 30.3 ERBB2 ESR1 KRT14 KRT15 MED12 MME
2 vulvar syringoma 10.6 ESR1 PGR
3 lung leiomyoma 10.6 ESR1 PGR
4 scirrhous adenocarcinoma 10.6 ERBB2 PGR
5 breast apocrine carcinoma 10.6 ERBB2 PGR
6 vulvar benign neoplasm 10.6 ESR1 PGR
7 vulvar leiomyoma 10.6 ESR1 PGR
8 intracystic papillary adenoma 10.5 ERBB2 PGR
9 progesterone-receptor negative breast cancer 10.5 ERBB2 PGR
10 progesterone resistance 10.5 ESR1 PGR
11 endometrium carcinoma in situ 10.5 PGR TP53
12 cribriform carcinoma 10.5 ESR1 PGR
13 comedo carcinoma 10.5 ERBB2 ESR1
14 bizarre leiomyoma 10.5 MED12 PGR
15 endometrial squamous cell carcinoma 10.5 ESR1 PGR
16 endometrial mucinous adenocarcinoma 10.5 ESR1 PGR
17 adenoid basal cell carcinoma 10.5 ESR1 PGR
18 endometrial clear cell adenocarcinoma 10.5 ESR1 TP53
19 gender identity disorder 10.5 ESR1 PGR
20 female reproductive endometrioid cancer 10.5 PGR TP53
21 olfactory groove meningioma 10.5 PGR TP53
22 uterine corpus serous adenocarcinoma 10.4 ERBB2 TP53
23 glioma susceptibility 1 10.4 ERBB2 TP53
24 estrogen excess 10.4 ESR1 PGR
25 chordoid glioma 10.4 PGR TP53
26 mammographic density 10.4 ESR1 PGR
27 retinitis pigmentosa 47 10.4 ESR1 PGR
28 non-proliferative fibrocystic change of the breast 10.4 ERBB2 TP53
29 papillary serous adenocarcinoma 10.4 PGR TP53
30 glassy cell carcinoma of the cervix 10.4 ERBB2 ESR1 PGR
31 breast medullary carcinoma 10.4 ERBB2 ESR1 PGR
32 breast scirrhous carcinoma 10.4 ERBB2 ESR1 PGR
33 progesterone-receptor positive breast cancer 10.4 ERBB2 ESR1 PGR
34 apocrine adenocarcinoma 10.4 ERBB2 ESR1 PGR
35 breast adenoid cystic carcinoma 10.4 ERBB2 ESR1 PGR
36 luminal breast carcinoma 10.4 ERBB2 ESR1 PGR
37 inflammatory breast carcinoma 10.4 ERBB2 ESR1 PGR
38 anterior cranial fossa meningioma 10.4 PGR TP53
39 bilateral breast cancer 10.4 ERBB2 ESR1 PGR
40 tubular adenocarcinoma 10.4 ERBB2 ESR1 PGR
41 triple-receptor negative breast cancer 10.4 ERBB2 ESR1 PGR
42 estrogen-receptor negative breast cancer 10.4 ERBB2 ESR1 PGR
43 reproductive organ benign neoplasm 10.4 ESR1 MED12 PGR
44 uterine benign neoplasm 10.4 ESR1 MED12 PGR
45 breast malignant phyllodes tumor 10.4 PGR PTS TP53
46 vestibular gland benign neoplasm 10.4 ESR1 PGR TP53
47 bartholin's gland adenoma 10.4 ESR1 PGR TP53
48 pleomorphic adenoma carcinoma 10.4 ERBB2 TP53
49 adenomyosis 10.4 ESR1 PGR
50 leiomyomatosis 10.4 ESR1 MED12 PGR

Graphical network of the top 20 diseases related to Breast Benign Neoplasm:



Diseases related to Breast Benign Neoplasm

Symptoms & Phenotypes for Breast Benign Neoplasm

MGI Mouse Phenotypes related to Breast Benign Neoplasm:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 PTS ESR1 TP53 MED12 PGR PIP
2 endocrine/exocrine gland MP:0005379 9.92 PTS TP53 KRT14 PGR PIP ERBB2
3 digestive/alimentary MP:0005381 9.91 TP53 KRT14 PIP ERBB2 PLVAP ESR1
4 integument MP:0010771 9.91 TP53 KRT14 MME PGR CD34 ERBB2
5 limbs/digits/tail MP:0005371 9.63 ESR1 TP53 MED12 PGR ERBB2 PLVAP
6 neoplasm MP:0002006 9.43 ESR1 TP53 KRT14 PGR CD34 ERBB2
7 reproductive system MP:0005389 9.17 PTS ESR1 KRT14 TP53 PGR PIP

Drugs & Therapeutics for Breast Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Breast Benign Neoplasm

Genetic Tests for Breast Benign Neoplasm

Anatomical Context for Breast Benign Neoplasm

MalaCards organs/tissues related to Breast Benign Neoplasm:

38
Breast

Publications for Breast Benign Neoplasm

Variations for Breast Benign Neoplasm

Expression for Breast Benign Neoplasm

Search GEO for disease gene expression data for Breast Benign Neoplasm.

Pathways for Breast Benign Neoplasm

Pathways related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.2 ESR1 MED12 TP53
2
Show member pathways
10.83 ERBB2 ESR1 PGR

GO Terms for Breast Benign Neoplasm

Biological processes related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular steroid hormone receptor signaling pathway GO:0030518 9.26 ESR1 MED12
2 replicative senescence GO:0090399 9.16 MME TP53
3 positive regulation of gene expression GO:0010628 9.02 CD34 ERBB2 PIP RHOXF2 TP53
4 paracrine signaling GO:0038001 8.96 CD34 PGR

Molecular functions related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 ERBB2 ESR1 KRT14 KRT15 MED12 MME
2 transcription factor binding GO:0008134 8.92 CD34 ESR1 MED12 TP53

Sources for Breast Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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