MCID: BRS046
MIFTS: 33

Breast Benign Neoplasm

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Breast Benign Neoplasm

MalaCards integrated aliases for Breast Benign Neoplasm:

Name: Breast Benign Neoplasm 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0060082
ICD10 33 D24

Summaries for Breast Benign Neoplasm

MalaCards based summary : Breast Benign Neoplasm is related to breast fibroadenoma and bartholin's gland benign neoplasm. An important gene associated with Breast Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Thyroid hormone signaling pathway and Signaling by ERBB4. The drugs Benzocaine and Isoflurane have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and prostate, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Breast Benign Neoplasm

Diseases in the Breast Cancer family:

Breast Benign Neoplasm Inflammatory Breast Carcinoma
Sporadic Breast Cancer Breast Carcinoma in Situ
Brip1-Related Breast Cancer

Diseases related to Breast Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
id Related Disease Score Top Affiliating Genes
1 breast fibroadenoma 10.9
2 bartholin's gland benign neoplasm 10.9 ESR1 PGR
3 gallbladder leiomyoma 10.8 ESR1 PGR
4 gastritis 10.8 ERBB2 PGR
5 fallopian tube benign neoplasm 10.8 ESR1 PGR
6 dartoic leiomyoma 10.8 ESR1 PGR
7 skin sarcoma 10.8 ERBB2 PGR
8 deafness, autosomal dominant 8/12 10.8 ESR1 PGR
9 her2-receptor negative breast cancer 10.8 ERBB2 PGR
10 blastema predominant kidney wilms' tumor 10.8 PGR TP53
11 superficial basal cell carcinoma 10.8 ESR1 PGR
12 sarcomatoid squamous cell skin carcinoma 10.8 ESR1 PGR
13 nerve fibre bundle defect 10.8 ERBB2 ESR1
14 bladder colloid adenocarcinoma 10.7 ESR1 PGR
15 osteogenesis imperfecta 10.7 ESR1 PGR
16 fallopian tube clear cell adenocarcinoma 10.7 ESR1 TP53
17 breast myoepithelial neoplasm 10.7 PGR TP53
18 intraductal breast myoepitheliosis 10.7 PGR TP53
19 congenital disorder of glycosylation, type if 10.7 ERBB2 TP53
20 endocervicitis 10.7 ERBB2 TP53
21 kallmann syndrome 10.7 ERBB2 PGR
22 holoprosencephaly 6 10.7 ESR1 PGR
23 acute thyroiditis 10.6 ESR1 PGR
24 breast myoepitheliosis 10.6 ESR1 TP53
25 breast pericanalicular fibroadenoma 10.6 PGR TP53
26 animal phobia 10.6 ERBB2 TP53
27 glaucoma, hereditary 10.6 ERBB2 ESR1 PGR
28 spinal cancer 10.6 ERBB2 ESR1 PGR
29 subglottis verrucous carcinoma 10.6 ERBB2 ESR1 PGR
30 retinitis pigmentosa 20 10.6 ESR1 PGR
31 her2-receptor positive breast cancer 10.6 ERBB2 ESR1 PGR
32 kidney clear cell sarcoma 10.6 ERBB2 ESR1 PGR
33 dmd-related dilated cardiomyopathy 10.6 ERBB2 ESR1 PGR
34 malignant thyroid stimulating hormone producing neoplasm of pituitary gland 10.6 ERBB2 ESR1 PGR
35 chronic salpingitis 10.6 ESR1 MME
36 testis seminoma 10.6 ERBB2 MME
37 cell type benign neoplasm 10.6 ERBB2 ESR1 PGR
38 panophthalmitis 10.6 MME PGR
39 ureter adenocarcinoma 10.6 ERBB2 ESR1 PGR
40 progesterone-receptor negative breast cancer 10.6 ERBB2 ESR1 PGR
41 prostatic acinar adenocarcinoma 10.6 PGR PTS TP53
42 central nervous system organ benign neoplasm 10.6 ESR1 PGR TP53
43 lung adenoma 10.6 ESR1 PGR TP53
44 central nervous system germ cell tumor 10.6 PGR TP53
45 cystic kidney disease 10.6 ERBB2 TP53
46 pseudounicornuate uterus 10.6 MME PGR
47 thoracic benign neoplasm 10.5 ESR1 MED12 PGR
48 intestinal perforation 10.5 ESR1 PGR TP53
49 gastrointestinal system benign neoplasm 10.5 ESR1 MED12 PGR
50 small intestine leiomyoma 10.5 KRT15 TP53

Graphical network of the top 20 diseases related to Breast Benign Neoplasm:



Diseases related to Breast Benign Neoplasm

Symptoms & Phenotypes for Breast Benign Neoplasm

MGI Mouse Phenotypes related to Breast Benign Neoplasm:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 ERBB2 ESR1 MED12 PGR PIP PLVAP
2 endocrine/exocrine gland MP:0005379 9.92 ESR1 KRT14 PGR PIP PLVAP PTS
3 digestive/alimentary MP:0005381 9.91 ERBB2 ESR1 KRT14 PIP PLVAP PTS
4 integument MP:0010771 9.91 CD34 ERBB2 ESR1 KRT14 MME PGR
5 limbs/digits/tail MP:0005371 9.63 ERBB2 ESR1 MED12 PGR PLVAP TP53
6 neoplasm MP:0002006 9.43 CD34 ERBB2 ESR1 KRT14 PGR TP53
7 reproductive system MP:0005389 9.17 KRT14 PGR PIP PTS TP53 ERBB2

Drugs & Therapeutics for Breast Benign Neoplasm

Drugs for Breast Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
2
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
3
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
4
Tamoxifen Approved Phase 4 10540-29-1 2733526
5
Butorphanol Approved, Illicit, Vet_approved Phase 4 58786-99-5, 42408-82-2 5361092
6
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
7
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
8
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
9 tannic acid Approved, Nutraceutical Phase 4
10 Alovudine Phase 4
11 Anti-Infective Agents Phase 4,Phase 2
12 Antiviral Agents Phase 4
13 Anesthetics Phase 4
14 Anesthetics, General Phase 4
15 Anesthetics, Inhalation Phase 4
16 Central Nervous System Depressants Phase 4
17 Platelet Aggregation Inhibitors Phase 4
18 Analgesics Phase 4
19 Analgesics, Non-Narcotic Phase 4
20 Anti-Inflammatory Agents Phase 4
21 Anti-Inflammatory Agents, Non-Steroidal Phase 4
22 Antimetabolites Phase 4
23 Antineoplastic Agents, Hormonal Phase 4
24 Antirheumatic Agents Phase 4
25 Bone Density Conservation Agents Phase 4,Phase 2
26 Dermatologic Agents Phase 4
27 Efamol Phase 4
28 Estrogen Antagonists Phase 4,Phase 2
29 Estrogen Receptor Modulators Phase 4,Phase 2
30 Estrogens Phase 4,Phase 2
31 Hormone Antagonists Phase 4,Phase 2,Phase 1
32 Hormones Phase 4,Phase 2,Phase 1
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1
34 Hypolipidemic Agents Phase 4
35 Lipid Regulating Agents Phase 4
36 Peripheral Nervous System Agents Phase 4
37 Selective Estrogen Receptor Modulators Phase 4,Phase 2
38 Analgesics, Opioid Phase 4
39 Antitussive Agents Phase 4
40 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
41 Cyclooxygenase Inhibitors Phase 4
42 Flurbiprofen axetil Phase 4
43 Narcotic Antagonists Phase 4
44 Narcotics Phase 4
45 Pharmaceutical Solutions Phase 4
46 Respiratory System Agents Phase 4
47 Evening Primrose Nutraceutical Phase 4
48
3,3'-diindolylmethane Investigational Phase 3 1968-05-4
49
Everolimus Approved Phase 2 159351-69-6 6442177
50
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189

Interventional clinical trials:

(show top 50) (show all 107)

id Name Status NCT ID Phase Drugs
1 18F-FLT Positron Emission Tomography and Magnetic Resonance Imaging of the Breast Unknown status NCT01956890 Phase 4 PET
2 Comparison of Sevoflurane and Isoflurane Anesthesia for Benign Breast Tumor Excision Completed NCT00575354 Phase 4 Sevoflurane;Isoflurane
3 Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer Completed NCT00999921 Phase 4 Tamoxifen;Evening Primrose Oil
4 Comparison of Pain Therapeutic Effects After Benign Mastectomy Completed NCT00519246 Phase 4 Saline;Opioid;Opioid;NSAID;NSAID;Opioid;Opioid
5 Quantitative Subharmonic Breast Imaging Active, not recruiting NCT01490892 Phase 4 3D HI and SHI of UCA
6 Safety and Aesthetic Outcomes of Breast Conserving Surgery With Peri-areolar Incision Approach Unknown status NCT01412788 Phase 3
7 Diet and Breast Cancer Prevention Trial Completed NCT00148057 Phase 3
8 Effectiveness of DIM Supplements to Increase 2-OHE1/16 Ratio Completed NCT02525159 Phase 3
9 Collection of FUJIFILM's 3Dimensional Mammograms Completed NCT01542814 Phase 3
10 The Detection of Circulating Tumor Cells (CTCs) in Breast Cancer With a Novel in Vivo Device Recruiting NCT03006055 Phase 3
11 Ultrasound Guided Percutaneous Microwave Ablation for Breast Lesions Recruiting NCT02860104 Phase 2, Phase 3
12 Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer Recruiting NCT03233191 Phase 3
13 Clinical Application of Near-infrared Fluorescence Guided Localization on Breast Surgery in Breast Cancer Unknown status NCT02473159 Phase 2 indocyanine green
14 Duct Endoscopy in Assessing Cellular Atypia in the Breast Duct Fluid of Women With a Genetic Risk for Breast Cancer Unknown status NCT00082979 Phase 2
15 Clinical Application of Near-infrared Fluorescence Guided Localization on Breast Surgery in Benign Breast Neoplasm. Completed NCT02172989 Phase 1, Phase 2
16 Sirolimus to Treat Cowden Syndrome and Other PTEN Hamartomatous Tumor Syndromes Completed NCT00971789 Phase 2 sirolimus
17 ICG Distribution Using NIF Imaging After IV Injection of ICG in Benign and Malignant Breast Cancer Tissue. Completed NCT01993576 Phase 1, Phase 2 Indocyanine Green
18 Analyzing the Composition of Tears to Identify Cancer Completed NCT00574678 Phase 1, Phase 2
19 Effect of Aromatase Inhibitors on Breast Magnetic Resonance Imaging (MRI) Completed NCT01129622 Phase 2 letrozole
20 Pilot Study of the Effect of Duavee® on Benign Breast Tissue Proliferation Recruiting NCT02729701 Phase 2 Duavee
21 A Prospective Clinical Study for Evaluation of Safe Resection Margin in Breast Conserving Surgery in Breast Cancer Recruiting NCT02817334 Phase 2 indocyanine green
22 Alternative Dosing of Exemestane Before Surgery in Treating Postmenopausal Patients With Stage 0-II Estrogen Positive Breast Cancer Recruiting NCT02598557 Phase 2 Exemestane
23 Docosahexaenoic Acid in Preventing Recurrence in Breast Cancer Survivors Active, not recruiting NCT01849250 Phase 2 Docosahexaenoic Acid
24 Prevention Strategy for Pre-Menopausal Women at High Risk for Development of Breast Cancer Active, not recruiting NCT01276704 Phase 2 Placebo;secoisolariciresinol
25 Spectroscopy of Breast Tissue Completed NCT00918216 Phase 1
26 Defined Green Tea Catechin Extract in Treating Women With Hormone Receptor Negative Stage I-III Breast Cancer Completed NCT00516243 Phase 1 defined green tea catechin extract
27 Clinical Research of 18F-Alfatide Ⅱ PET/CT in Breast Cancer Recruiting NCT02582801 Phase 1 18F-Alfatide Ⅱ PET/CT
28 FBnTP Imaging of Breast Cancer Recruiting NCT02204462 Phase 1 FBnTP
29 Detection of Benign and Malignant Thyroid and Breast Tumors by Fourier Transform Infrared Spectrometry Unknown status NCT01668238
30 China CellSearch Study Unknown status NCT01116869
31 Using Test of SCM for Detection Breast Cancer Unknown status NCT00407706
32 Survey of Optical Values of the Breast Using Radiation-Free Pressure-Free Optical Scanning Unknown status NCT00671385
33 Tumor Bank for Tissue Samples Unknown status NCT01789229
34 Biomarker Breast Pap Test Unknown status NCT01683305
35 Tumor Bank for Blood Samples Unknown status NCT01763125
36 Clinical Trial of Quantitative Detection Kit for Hsp90α in Breast Cancer Unknown status NCT02324101
37 OctavaPink for Women With Dense Breast After Negative Mammography Unknown status NCT02209389
38 Women At Risk: The High Risk Breast Cancer Program Unknown status NCT01034891
39 Hypodontia and Ovarian Cancer Unknown status NCT01470235
40 Evaluate the Use of the Magnetic Resonance Spectroscopy in Determining if the Breast Tumor is Benign or Malignant Completed NCT00639171
41 CRRS-4 Pivotal Somo•v™ ABUS ROC Reader Observer Study Completed NCT01424956
42 Role of Cytochrome P450 2D6 (CYP2D6) *4 Polymorphism,in Malignant Breast Diseases Completed NCT00539422
43 The Ghana Breast Health Study Completed NCT01661023
44 Epigenetic Testing for Breast Cancer Risk Stratification Completed NCT01501656
45 Prolactin Receptor and Breast Diseases Completed NCT00842465
46 Biomarkers for Breast Cancer Risk in African American Women Completed NCT01736306
47 Markers for Breast Cancer Completed NCT00339248
48 Detection of Aggressive Breast Tumors Using Tc-99m-NC100692 Completed NCT00888589
49 VEGF Early Imaging for Breast Cancer Completed NCT00991978 Early Phase 1
50 Improved Breast MRI With SWIFT Completed NCT01156987

Search NIH Clinical Center for Breast Benign Neoplasm

Genetic Tests for Breast Benign Neoplasm

Anatomical Context for Breast Benign Neoplasm

MalaCards organs/tissues related to Breast Benign Neoplasm:

39
Breast, Testes, Prostate, Liver, Bone, Endothelial, Thyroid

Publications for Breast Benign Neoplasm

Variations for Breast Benign Neoplasm

Expression for Breast Benign Neoplasm

Search GEO for disease gene expression data for Breast Benign Neoplasm.

Pathways for Breast Benign Neoplasm

Pathways related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.2 ESR1 MED12 TP53
2
Show member pathways
10.83 ERBB2 ESR1 PGR

GO Terms for Breast Benign Neoplasm

Biological processes related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intracellular steroid hormone receptor signaling pathway GO:0030518 9.26 ESR1 MED12
2 replicative senescence GO:0090399 9.16 MME TP53
3 positive regulation of gene expression GO:0010628 9.02 CD34 ERBB2 PIP RHOXF2 TP53
4 paracrine signaling GO:0038001 8.96 CD34 PGR

Molecular functions related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 8.92 CD34 ESR1 MED12 TP53

Sources for Breast Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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