MCID: BRS047
MIFTS: 85

Breast Cancer malady

Cancer category

Summaries for Breast Cancer

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 21Genetics Home Reference, 46Novus Biologicals, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Breast cancer affects one in eight women during their lives. breast cancer kills more women in the united states than any cancer except lung cancer. no one knows why some women get breast cancer, but there are a number of risk factors. risks that you cannot change include age - the chance of getting breast cancer rises as a woman gets older genes - there are two genes, brca1 and brca2, that greatly increase the risk. women who have family members with breast or ovarian cancer may wish to be tested. personal factors - beginning periods before age 12 or going through menopause after age 55 other risks include being overweight, using hormone replacement therapy (also called menopausal hormone therapy), taking birth control pills, drinking alcohol, not having children or having your first child after age 35 or having dense breasts. symptoms of breast cancer may include a lump in the breast, a change in size or shape of the breast or discharge from a nipple. breast self-exam and mammography can help find breast cancer early when it is most treatable. treatment may consist of radiation, lumpectomy, mastectomy, chemotherapy and hormone therapy. men can have breast cancer, too, but the number of cases is small. nih: national cancer institute

MalaCards: Breast Cancer, also known as breast carcinoma, is related to male breast cancer and bilateral breast cancer. An important gene associated with Breast Cancer is CHEK2 (checkpoint kinase 2), and among its related pathways are Integrated Breast Cancer Pathway and Integrated Pancreatic Cancer Pathway. The drugs aminoglutethimide and chlorambucil and the compounds camptothecin and doxorubicin have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and cellular.

Disease Ontology:8 A thoracic cancer that originates in the mammary gland.

CDC:3 Breast cancer is the most common cancer among American women. Having regular mammograms can lower the risk of dying from breast cancer. If you are 50 to 74 years old, be sure to have a screening mammogram every two years. If you are 40 to 49 years old, talk to your doctor about when to start and how often to get a screening mammogram.

Genetics Home Reference:21 Breast cancer is a disease in which certain cells in the breast become abnormal and multiply without control or order to form a tumor. The most common form of breast cancer begins in cells lining the ducts that carry milk to the nipple (ductal cancer). Other forms of breast cancer begin in the glands that produce milk (lobular cancer) or in other parts of the breast.

Novus Biologicals:46 Breast cancer is a malignant tumor that originates from breast tissue cells. Although most breast cancers initiate in the cells that line the breast ducts, some begin in the breast lobules and other tissues. As with all cancers, there is a genetic and environmental component of developing breast cancer. Women with defects in the BRCA1 and BRCA2 genes have up to an 80% chance of getting breast cancer. Research has also found that defects in the ErbB-2 gene lead to increased levels of the protein cyclin D1. Cyclin D1 then activates CDK4, which causes proliferation of cellular division. Blocking CDK4 activity may lead to effective breast cancer treatments.

Wikipedia:64 Breast cancer is a type of cancer originating from breast tissue, most commonly from the inner lining of... more...

Description from OMIM:47 114480

Aliases & Classifications for Breast Cancer

Sources:
64Wikipedia, 8Disease Ontology, 9diseasecard, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 22GTR, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

breast cancer 8 9 64 21 47 10 45 34
breast carcinoma 8 21 10 45 61
malignant neoplasm of breast 8 64 21
cancer of breast 64 22 21
mammary cancer 8 64 21
malignant tumor of breast 64 21
mammary tumor 8 45
malignant tumor of the breast 8
carcinoma of male breast 61
animal mammary neoplasms 61
carcinoma of breast nos 8
breast cancer, familial 21
primary breast cancer 8
carcinoma of breast 8
malignant neoplasms 61
male breast cancer 64
mammary carcinoma 8
mammary neoplasms 61
ca breast - nos 8
breast tumor 8


Related Diseases for Breast Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Breast Cancer family:

bilateral breast cancer familial breast cancer
breast cancer, type 3 breast cancer, early-onset

Diseases related to Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 810)
idRelated DiseaseScoreTop Affiliating Genes
1male breast cancer31.9ESR1, BRCA1
2bilateral breast cancer31.6BRCA1, ATM, CHEK2, ESR1
3breast cancer, invasive ductal31.4BRCA1, TFF1, ATM, ESR1, TP53
4colorectal cancer31.1TP53, NCOA3, ATM, TFF1
5ductal carcinoma in situ31.1BRCA1, ESR1, TP53
6thyroid cancer31.0TP53
7ataxia telangiectasia30.9BRCA1, XRCC3, ATM, CHEK2, TP53
8adenocarcinoma30.7BRCA1, XRCC3, TFF1, NCOA3, CHEK2, ABCG2
9adenoma30.7BRCA1, XRCC3, TFF1, ATM, NCOA3, TP53
10stomach cancer30.5TFF1, CHEK2, ABCG2, TP53
11nijmegen breakage syndrome30.3CHEK2, ATM, BRCA1
12xeroderma pigmentosum30.3BRCA1, XRCC3, TP53
13squamous cell carcinoma30.2XRCC3, TFF1, NCOA3, CHEK2, ABCG2, TP53
14li-fraumeni syndrome30.2ESR1, TFF1, BRCA1
15bloom syndrome30.1BRCA1, ATM
16werner syndrome30.1BRCA1, ATM
17astrocytoma29.8TP53, BRCA1
18cystadenoma29.8BRCA1
19ulcerative colitis29.8TP53
20breast cancer susceptibility11.3
21familial breast cancer11.3
22estrogen-receptor positive breast cancer11.2
23sporadic breast cancer11.1
24estrogen-receptor negative breast cancer11.1
25vascular cancer11.1
26breast cancer, early-onset11.0
27hypoxia10.9
28bone marrow cancer10.9
29brain cancer10.9
30estrogen resistance10.8
31oral cancer10.8
32breast lymphoma10.7
33triple-receptor negative breast cancer10.7
34breast cancer, somatic10.7
35radiation induced cancer10.7
36breast cancer, lobular10.7
37progesterone-receptor positive breast cancer10.7
38amenorrhea10.7
39acute leukemia10.7
40colon cancer, advanced10.6
41breast reconstruction10.6
42her2-receptor positive breast cancer10.6
43ataxia10.6
44progesterone-receptor negative breast cancer10.6
45n syndrome10.6
46cancer progression/metastasis10.6
47insulin resistance10.6
48tongue cancer10.6
49fanconi's anemia10.5
50nasopharynx carcinoma10.5

Graphical network of the top 20 diseases related to Breast Cancer:



Diseases related to breast cancer

Clinical Features for Breast Cancer

Sources:
47OMIM
See all sources

Clinical features from OMIM:

114480

Drugs & Therapeutics for Breast Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Breast Cancer

Search NIH Clinical Center for Breast Cancer

Search CenterWatch for Breast Cancer

Inferred drug relations via UMLS61/NDF-RT41:

Show with subtypes

Genetic Tests for Breast Cancer

Sources:
22GTR
See all sources

Genetic tests related to Breast Cancer:

id Genetic test Affiliating Genes
1 Breast Cancer, Susceptibility To22

Anatomical Context for Breast Cancer

Animal Models for Breast Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Breast Cancer

Sources:
51PubMed
See all sources

Articles related to Breast Cancer:

(show top 50)    (show all 23536)
idTitleAuthorsYear
1
Association between polymorphisms within the susceptibility region 8q24 and breast cancer in a Chinese population. (24414391)
2014
2
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. (23535731)
2013
3
Trends in risk reduction practices for the prevention of lymphedema in the first 12 months after breast cancer surgery. (23266421)
2013
4
Survivorship education for Latina breast cancer survivors: Empowering Survivors through education. (24416043)
2013
5
Chemotherapeutic Potential of 2-[Piperidinoethoxyphenyl]-3-Phenyl-2H-Benzo(b)pyran in Estrogen Receptor- Negative Breast Cancer Cells: Action via Prevention of EGFR Activation and Combined Inhibition of PI-3-K/Akt/FOXO and MEK/Erk/AP-1 Pathways. (23840429)
2013
6
Complementary or Alternative Medicine as Possible Determinant of Decreased Persistence to Aromatase Inhibitor Therapy among Older Women with Non-Metastatic Breast Cancer. (24367488)
2013
7
The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714 predict adverse outcome for breast cancer patients. (23270421)
2012
8
Anti-beta2-glycoprotein I antibody and cerebellar ataxia in breast cancer. (22427365)
2012
9
HER-2 positive and p53 negative breast cancers are associated with poor prognosis. (21599513)
2011
10
Vascular endothelial growth factor secreted by activated stroma enhances angiogenesis and hormone-independent growth of estrogen receptor-positive breast cancer. (20332242)
2010
11
Amenorrhea from breast cancer therapy--not a matter of dose. (21121855)
2010
12
Prospective multicenter comparison of proliferation and other prognostic factors in lymph node negative lobular invasive breast cancer. (19568929)
2010
13
Deleterious CHEK2 1100delC and L303X mutants identified among 38 human breast cancer cell lines. (18297428)
2009
14
Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers--results of a large scale microarray analysis. (19054665)
2009
15
Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk. (19846565)
2009
16
Estrogen alpha and progesterone receptor expression in the normal mammary epithelium in relation to breast cancer risk. (18798271)
2009
17
The subcellular localization of IGFBP5 affects its cell growth and migration functions in breast cancer. (19341485)
2009
18
Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment. (19365520)
2009
19
Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling. (18446232)
2008
20
Expression of the cell to cell adhesion molecule, ALCAM, in breast cancer patients and the potential link with skeletal metastasis. (18202807)
2008
21
Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells. (17297458)
2007
22
Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells. (17690249)
2007
23
ABCB1 and GST polymorphisms associated with TP53 status in breast cancer. (17301692)
2007
24
Fulvestrant: pharmacologic profile versus existing endocrine agents for the treatment of breast cancer. (16912252)
2006
25
Interrelationships between serum leptin, IGF-1, IGFBP3, C-peptide and prolactin and breast cancer risk in young women. (16502016)
2006
26
B cell translocation gene 1 contributes to antisense Bcl-2-mediated apoptosis in breast cancer cells. (16818519)
2006
27
The role of the epidermal growth factor receptor in breast cancer. (16947082)
2006
28
UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 as a new immunohistochemical breast cancer marker. (16260590)
2006
29
Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer. (15755728)
2005
30
Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells. (15691880)
2005
31
Increased levels of SPARC (osteonectin) in human breast cancer tissues and its association with clinical outcomes. (15763438)
2005
32
Genetic susceptibility to prostate, breast, and colorectal cancer among Nordic twins. (15737078)
2005
33
Increased risk of breast cancer among female relatives of patients with ataxia-telangiectasia: a causal relationship? (16222317)
2005
34
Expression and activation of MAPK pathway signaling molecules in human breast cancer cell lines]. (15193230)
2004
35
Cytokine gene polymorphisms and breast cancer susceptibility and prognosis. (15265021)
2004
36
N-acetyltransferase 2 (NAT2) genotypes, cigarette smoking, and the risk of breast cancer. (15225898)
2004
37
MAPK inhibition by 1alpha,25(OH)2-Vitamin D3 in breast cancer cells. Evidence on the participation of the VDR and Src. (15225787)
2004
38
Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung. (15131050)
2004
39
A pituitary gene encodes a protein that produces differentiation of breast and prostate cancer cells. (14745005)
2004
40
Effect of raloxifene on insulin-like growth factor-I, insulin-like growth factor binding protein-3, and leptin in premenopausal women at high risk for developing breast cancer. (14693739)
2003
41
Cadherins as predictive markers of nodal metastasis in breast cancer. (11353052)
2001
42
Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression. (10966001)
2000
43
Distribution and prognostic value of the fibroblast growth factor-2 low-affinity binding sites in human breast cancer. (11268476)
2000
44
Transcriptional activation of thymidylate synthase by 17beta-estradiol in MCF-7 human breast cancer cells. (10875244)
2000
45
Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer. (10505111)
1999
46
Distinct molecular pathogeneses of early-onset breast cancers in BRCA1 and BRCA2 mutation carriers: a population-based study. (10213514)
1999
47
Maspin gene expression in tumor suppression induced by overexpressing manganese-containing superoxide dismutase cDNA in human breast cancer cells. (9635871)
1998
48
A comparison outcome of male breast cancer with female breast cancer. (9124623)
1997
49
Low incidence of familial breast cancer among Hispanic women. (1617126)
1992
50
CASE REPORTS FROM THE COMMITTEE ON CANCER; SIMULTANEOUS BILATERAL BREAST CANCER. (14302876)
1965

Genetic Variations for Breast Cancer

Expression for genes affiliated with Breast Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Breast Cancer

Search GEO for disease gene expression data for Breast Cancer.

Pathways for genes affiliated with Breast Cancer

Sources:
38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology, 52QIAGEN, 12EMD Millipore, 56SinoBiological, 54Reactome, 50PharmGKB
See all sources

Pathways related to Breast Cancer according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
112.8TP53, BRCA1, XRCC3, PHB, ATM, NCOA3
212.0BRCA1, TFF1, ATM, CHEK2, ESR1, TP53
3
Hide members
11.8BRCA1, PPM1D, ATM, CHEK2, TP53
4
Hide members
11.8BRCA1, PPM1D, PHB, ATM, CHEK2
5
Hide members
11.8BRCA1, ATM, CHEK2, BARD1, TP53
611.8BRCA1, ATM, CHEK2, BARD1, TP53
7
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
11.8TP53, BARD1, CHEK2, ATM, BRCA1
811.8BRCA1, ATM, CHEK2, BARD1, TP53
9
Hide members
11.8ATM, NCOA3, CHEK2, HMMR, TP53
10
Hide members
11.8BRCA1, ATM, CHEK2, BARD1, ESR1
1111.5PPM1D, ATM, CHEK2, TP53
1211.5TP53, CHEK2, ATM, BRCA1
1311.5BRCA1, ATM, CHEK2, TP53
14
Cell cycle Cell cycle (generic schema)
Hide members
11.5ESR1, CHEK2, NCOA3, BRCA1
1511.5BRCA1, TFF1, NCOA3, ESR1
16
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
Hide members
11.3TP53, CHEK2, ATM
17
Hide members
11.3CHEK2, ATM, BRCA1
18
Hide members
11.3PALB2, ATM, BRCA1
1911.3TP53, ATM, BRCA1
2011.3BRCA1, ATM, TP53
21
Hide members
11.3BARD1, ATM, BRCA1
22
Hide members
11.3XRCC3, ABCG2, TP53
2311.3TP53, ESR1, ABCG2
24
Hide members
11.0CHEK2, ATM
2511.0CHEK2, TP53
2611.0TP53, PALB2
2711.0XRCC3, TP53
28
Hide members
11.0ATM, BRCA1

Compounds for genes affiliated with Breast Cancer

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 29IUPHAR, 2BitterDB, 24HMDB
See all sources

Compounds related to Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1camptothecin45 60 1114.8TP53, ABCG2, CHEK2, ATM, PHB, XRCC3
2doxorubicin45 50 1114.5BRCA1, ATM, CHEK2, ABCG2, ESR1, TP53
3genistein45 29 60 2 11 2417.5BRCA1, TFF1, ATM, CHEK2, ABCG2, ESR1
4cisplatin45 50 60 1115.5BRCA1, XRCC3, ATM, CHEK2, ABCG2, TP53
5progesterone45 60 29 11 2416.4BRCA1, TFF1, NCOA3, ABCG2, ESR1, TP53
6steroid4512.4BRCA1, TFF1, PHB, NCOA3, ABCG2, ESR1
7phosphatidylinositol4512.4BRCA1, ATM, NCOA3, CHEK2, CDS1, ABCG2
8hydroxyurea45 50 1114.2BRCA1, ATM, CHEK2, ABCG2, TP53
9mitomycin c4512.2TP53, ABCG2, ATM, XRCC3, BRCA1
10caffeine45 50 29 2 11 2417.2BRCA1, XRCC3, ATM, CHEK2, TP53
11etoposide45 50 60 1115.2BRCA1, ATM, CHEK2, ABCG2, TP53
12retinoic acid45 2413.2BRCA1, TFF1, NCOA3, CHEK2, ESR1, TP53
13paraffin4512.1BRCA1, TFF1, ATM, ESR1, TP53
14cycloheximide4512.0TP53, ESR1, NCOA3, TFF1, BRCA1
15bpde4512.0BRCA1, ATM, CHEK2, TP53
16aphidicolin4512.0BRCA1, ATM, CHEK2, TP53
17topotecan45 1113.0BRCA1, ATM, ABCG2, TP53
184-hydroxytamoxifen4511.9BRCA1, TFF1, NCOA3, ESR1
19gemcitabine45 50 1113.9BRCA1, CHEK2, ABCG2, TP53
20docetaxel45 50 60 1114.9TP53, ESR1, ABCG2, BRCA1
21cyclophosphamide45 50 1113.9TP53, ESR1, ABCG2, BRCA1
225fluorouracil4511.8BRCA1, ABCG2, ESR1, TP53
23retinoid4511.8TP53, ESR1, NCOA3, TFF1
24n acetylcysteine4511.7XRCC3, ATM, CHEK2, TP53
25testosterone45 60 11 2414.7BRCA1, TFF1, NCOA3, ABCG2, ESR1
26daidzein4511.7BRCA1, TFF1, ESR1
27naringenin45 1112.7TFF1, ABCG2, ESR1
28taxane4511.7TP53, ESR1, ABCG2
29sn 3845 6012.7CHEK2, ABCG2, TP53
30indole-3-carbinol4511.6BRCA1, ESR1, TP53
31diethylstilbestrol45 29 1113.6TFF1, ABCG2, ESR1
32paclitaxel45 50 1113.6BRCA1, ABCG2, ESR1, TP53
33benzo(a)pyrene4511.6BRCA1, ABCG2, TP53
34oxaliplatin45 50 1113.6TP53, ABCG2, BRCA1
35leptomycin b45 6012.5TP53, PHB, BRCA1
36carboplatin45 50 1113.4TP53, ABCG2, BRCA1
37tamoxifen45 50 29 1114.4NCOA3, TFF1
38bleomycin45 1112.4BRCA1, ATM, TP53
39adriamycin4511.4ABCG2, CHEK2
40arzoxifene4511.4TFF1, ESR1
41neocarzinostatin4511.4CHEK2, ATM
42equol4511.3ESR1, TFF1
43biochanin a4511.3ABCG2, TFF1
44nocodazole45 1112.3TP53, CHEK2, BRCA1
45cytarabine45 50 1113.3TP53, ABCG2, ATM
46nonylphenol4511.2TFF1, ESR1
47rapamycin4511.2ABCG2, CHEK2, NCOA3, ATM
48estrogen4511.2BARD1
49resveratrol45 60 11 2414.1TFF1
50estradiol45 11 2413.1NCOA3

GO Terms for genes affiliated with Breast Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565412.0BRCA1, PHB, ATM, CHEK2, PALB2, ESR1
2BRCA1-A complexGO:07053111.0BARD1, BRCA1
3BRCA1-BARD1 complexGO:03143610.9BARD1, BRCA1

Biological processes related to Breast Cancer according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1response to DNA damage stimulusGO:00697412.3TP53, BRCA1, XRCC3, ATM, CHEK2, BARD1
2DNA repairGO:00628112.0BRCA1, XRCC3, ATM, BARD1, PALB2
3positive regulation of transcription, DNA-dependentGO:04589311.8TP53, CHEK2, NCOA3, PHB, BRCA1
4double-strand break repairGO:00630211.8BRCA1, ATM, CHEK2, TP53
5regulation of apoptotic processGO:04298111.7TP53, ESR1, PHB, BRCA1
6replicative senescenceGO:09039911.5TP53, CHEK2, ATM
7intrinsic apoptotic signaling pathway in response to DNA damageGO:00863011.5CHEK2, ATM, BRCA1
8somitogenesisGO:00175611.5ATM, PALB2, TP53
9double-strand break repair via homologous recombinationGO:00072411.4BRCA1, ATM, PALB2
10DNA damage induced protein phosphorylationGO:00697511.1CHEK2, ATM
11protein K6-linked ubiquitinationGO:08502011.1BRCA1, BARD1
12positive regulation of cell cycle arrestGO:07115811.0TP53, BRCA1
13vagina developmentGO:06006810.9NCOA3, ESR1
14DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.7TP53, BRCA1

Molecular functions related to Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.8TP53, BRCA1, XRCC3, PPM1D, TFF1, PHB
2protein N-terminus bindingGO:04748511.3TP53, NCOA3, ATM

Products for genes affiliated with Breast Cancer

  • Antibodies
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  • Lysates
  • Antibodies

Sources for Breast Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet