MCID: BRS047
MIFTS: 85

Breast Cancer malady

Cancer category

Summaries for Breast Cancer

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 21Genetics Home Reference, 46Novus Biologicals, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Breast cancer affects one in eight women during their lives. breast cancer kills more women in the united states than any cancer except lung cancer. no one knows why some women get breast cancer, but there are a number of risk factors. risks that you cannot change include age - the chance of getting breast cancer rises as a woman gets older genes - there are two genes, brca1 and brca2, that greatly increase the risk. women who have family members with breast or ovarian cancer may wish to be tested. personal factors - beginning periods before age 12 or going through menopause after age 55 other risks include being overweight, using hormone replacement therapy (also called menopausal hormone therapy), taking birth control pills, drinking alcohol, not having children or having your first child after age 35 or having dense breasts. symptoms of breast cancer may include a lump in the breast, a change in size or shape of the breast or discharge from a nipple. breast self-exam and mammography can help find breast cancer early when it is most treatable. treatment may consist of radiation, lumpectomy, mastectomy, chemotherapy and hormone therapy. men can have breast cancer, too, but the number of cases is small. nih: national cancer institute

MalaCards: Breast Cancer, also known as breast carcinoma, is related to male breast cancer and bilateral breast cancer. An important gene associated with Breast Cancer is CHEK2 (checkpoint kinase 2), and among its related pathways are Integrated Breast Cancer Pathway and Integrated Pancreatic Cancer Pathway. The drugs aminoglutethimide and chlorambucil and the compounds camptothecin and doxorubicin have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and cellular.

Disease Ontology:8 A thoracic cancer that originates in the mammary gland.

CDC:3 Breast cancer is the most common cancer among American women. Having regular mammograms can lower the risk of dying from breast cancer. If you are 50 to 74 years old, be sure to have a screening mammogram every two years. If you are 40 to 49 years old, talk to your doctor about when to start and how often to get a screening mammogram.

Genetics Home Reference:21 Breast cancer is a disease in which certain cells in the breast become abnormal and multiply without control or order to form a tumor. The most common form of breast cancer begins in cells lining the ducts that carry milk to the nipple (ductal cancer). Other forms of breast cancer begin in the glands that produce milk (lobular cancer) or in other parts of the breast.

Novus Biologicals:46 Breast cancer is a malignant tumor that originates from breast tissue cells. Although most breast cancers initiate in the cells that line the breast ducts, some begin in the breast lobules and other tissues. As with all cancers, there is a genetic and environmental component of developing breast cancer. Women with defects in the BRCA1 and BRCA2 genes have up to an 80% chance of getting breast cancer. Research has also found that defects in the ErbB-2 gene lead to increased levels of the protein cyclin D1. Cyclin D1 then activates CDK4, which causes proliferation of cellular division. Blocking CDK4 activity may lead to effective breast cancer treatments.

Wikipedia:64 Breast cancer is a type of cancer originating from breast tissue, most commonly from the inner lining of... more...

Description from OMIM:47 114480

Aliases & Classifications for Breast Cancer

Sources:
8Disease Ontology, 9diseasecard, 64Wikipedia, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

breast cancer 8 9 64 21 47 10 45 34
breast carcinoma 8 21 10 45 61
malignant neoplasm of breast 8 64 21
cancer of breast 64 22 21
mammary cancer 8 64 21
malignant tumor of breast 64 21
mammary tumor 8 45
malignant tumor of the breast 8
animal mammary neoplasms 61
carcinoma of male breast 61
carcinoma of breast nos 8
breast cancer, familial 21
primary breast cancer 8
carcinoma of breast 8
malignant neoplasms 61
male breast cancer 64
mammary carcinoma 8
mammary neoplasms 61
ca breast - nos 8
breast tumor 8


Related Diseases for Breast Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Breast Cancer family:

bilateral breast cancer familial breast cancer
breast cancer, type 3 breast cancer, early-onset

Diseases related to Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 810)
idRelated DiseaseScoreTop Affiliating Genes
1male breast cancer31.9ESR1, BRCA1
2bilateral breast cancer31.6BRCA1, ATM, CHEK2, ESR1
3breast cancer, invasive ductal31.4BRCA1, TFF1, ATM, ESR1, TP53
4colorectal cancer31.1TP53, NCOA3, ATM, TFF1
5ductal carcinoma in situ31.1BRCA1, ESR1, TP53
6thyroid cancer31.0TP53
7ataxia telangiectasia30.9BRCA1, XRCC3, ATM, CHEK2, TP53
8adenocarcinoma30.7BRCA1, XRCC3, TFF1, NCOA3, CHEK2, ABCG2
9adenoma30.7BRCA1, XRCC3, TFF1, ATM, NCOA3, TP53
10stomach cancer30.5TFF1, CHEK2, ABCG2, TP53
11nijmegen breakage syndrome30.3CHEK2, ATM, BRCA1
12xeroderma pigmentosum30.3BRCA1, XRCC3, TP53
13squamous cell carcinoma30.2XRCC3, TFF1, NCOA3, CHEK2, ABCG2, TP53
14li-fraumeni syndrome30.2ESR1, TFF1, BRCA1
15bloom syndrome30.1BRCA1, ATM
16werner syndrome30.1BRCA1, ATM
17astrocytoma29.8TP53, BRCA1
18cystadenoma29.8BRCA1
19ulcerative colitis29.8TP53
20breast cancer susceptibility11.3
21familial breast cancer11.3
22estrogen-receptor positive breast cancer11.2
23sporadic breast cancer11.1
24estrogen-receptor negative breast cancer11.1
25vascular cancer11.1
26breast cancer, early-onset11.0
27hypoxia10.9
28bone marrow cancer10.9
29brain cancer10.9
30estrogen resistance10.8
31oral cancer10.8
32breast lymphoma10.7
33triple-receptor negative breast cancer10.7
34breast cancer, somatic10.7
35radiation induced cancer10.7
36breast cancer, lobular10.7
37progesterone-receptor positive breast cancer10.7
38amenorrhea10.7
39acute leukemia10.7
40colon cancer, advanced10.6
41breast reconstruction10.6
42her2-receptor positive breast cancer10.6
43ataxia10.6
44progesterone-receptor negative breast cancer10.6
45n syndrome10.6
46cancer progression/metastasis10.6
47insulin resistance10.6
48tongue cancer10.6
49fanconi's anemia10.5
50nasopharynx carcinoma10.5

Graphical network of the top 20 diseases related to Breast Cancer:



Diseases related to breast cancer

Clinical Features for Breast Cancer

Sources:
47OMIM
See all sources

Clinical features from OMIM:

114480

Drugs & Therapeutics for Breast Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Breast Cancer

Search NIH Clinical Center for Breast Cancer

Search CenterWatch for Breast Cancer

Inferred drug relations via UMLS61/NDF-RT41:

Show with subtypes

Genetic Tests for Breast Cancer

Sources:
22GTR
See all sources

Genetic tests related to Breast Cancer:

id Genetic test Affiliating Genes
1 Breast Cancer, Susceptibility To22

Anatomical Context for Breast Cancer

Animal Models for Breast Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Breast Cancer

Sources:
51PubMed
See all sources

Articles related to Breast Cancer:

(show top 50)    (show all 23536)
idTitleAuthorsYear
1
Vitamin D receptor genotype rs731236 (Taq1) and breast cancer prognosis. (23300018)
2013
2
Adjuvant therapy with tamoxifen compared to aromatase inhibitors for 257 male breast cancer patients. (23224235)
2013
3
Clinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers. (22520950)
2012
4
Radiation resistance due to high expression of miR-21 and G2/M checkpoint arrest in breast cancer cells. (23216894)
2012
5
FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer. (21860419)
2012
6
Survival from synchronous bilateral breast cancer: the experience of surgeons participating in the breast audit of the Society of Breast Surgeons of Australia and New Zealand. (22799341)
2012
7
Endometrial mullerian adenosarcoma after toremifene treatment in breast cancer patients: a case report. (21278890)
2010
8
Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells. (20687930)
2010
9
Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients. (19228750)
2009
10
Dual FGF-2 and intergrin alpha5beta1 signaling mediate GRAF-induced RhoA inactivation in a model of breast cancer dormancy. (19308677)
2009
11
Nerve growth factor/nuclear factor-kappaB pathway as a therapeutic target in breast cancer. (18716795)
2009
12
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. (18058224)
2008
13
Androgen receptor expression in breast cancer: relationship with clinicopathological factors and biomarkers. (18946753)
2008
14
Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease. (18728668)
2008
15
The extracellular matrix protein ITIH5 is a novel prognostic marker in invasive node-negative breast cancer and its aberrant expression is caused by promoter hypermethylation. (17653090)
2008
16
ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions. (17537873)
2007
17
Association of p53 gene alterations with the expression of antiapoptotic survivin splice variants in breast cancer. (16847456)
2007
18
RT-PCR determination of maspin and mammaglobin B in peripheral blood of healthy donors and breast cancer patients. (16357022)
2006
19
Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. (16648044)
2006
20
Occult breast cancer presenting as axillary metastases. (15996865)
2006
21
p53 protein accumulation predicts resistance to endocrine therapy and decreased post-relapse survival in metastatic breast cancer. (16869955)
2006
22
E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. (16495925)
2006
23
Hereditary Breast-Ovarian Cancer Team of the University Medical Centre Groningen (UMCG) - a Report. (20223045)
2005
24
Resveratrol regulates insulin-like growth factor-II in breast cancer cells. (16037384)
2005
25
Geraniol and beta-ionone inhibit proliferation, cell cycle progression, and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity. (15450939)
2004
26
Impairment of the antiproliferative effect of glucocorticosteroids by 11beta-hydroxysteroid dehydrogenase type 2 overexpression in MCF-7 breast-cancer cells. (15305225)
2004
27
Functional and molecular characteristics of system L in human breast cancer cells. (12659948)
2003
28
Interleukin-6 -174G-->C polymorphism is associated with improved outcome in high-risk breast cancer. (14633738)
2003
29
Nipple aspirate fluid expression of urokinase-type plasminogen activator, plasminogen activator inhibitor-1, and urokinase-type plasminogen activator receptor predicts breast cancer diagnosis and advanced disease. (14527916)
2003
30
Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer. (12220518)
2002
31
Cyclin E and survival in patients with breast cancer. (12432043)
2002
32
Novel therapeutic approach: ligands for PPARgamma and retinoid receptors induce apoptosis in bcl-2-positive human breast cancer cells. (12186376)
2002
33
Clinical and pathological characteristics and clinical course of patients with breast cancer and BRCA1/BRCA2 mutations]. (11481082)
2001
34
HER2 overexpression in various tumor types, focussing on its relationship to the development of invasive breast cancer. (11521715)
2001
35
BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. (10943845)
2000
36
Effect of transforming growth factor beta 2 on oestrogen metabolism in the MCF-7 breast cancer cell line. (10823131)
2000
37
Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase pathways. (10399957)
1999
38
The regulation of oestrone sulphate formation in breast cancer cells. (10369410)
1999
39
Impact of steroid receptors, pS2 and cathepsin D on the outcome of N+ postmenopausal breast cancer patients treated with tamoxifen. (9681297)
1998
40
Regulation of tumor suppressor proteins, p53 and retinoblastoma, by estrogen and antiestrogens in breast cancer cells. (9285694)
1997
41
Relation of serum levels of testosterone and dehydroepiandrosterone sulfate to risk of breast cancer in postmenopausal women. (9169912)
1997
42
Prospective study of the prognostic significance of epidermal growth factor receptor in primary breast cancer. (8600054)
1996
43
Protein tyrosine phosphatase activity as a diagnostic parameter in breast cancer. (7749152)
1995
44
A one minute pulse of estradiol to MCF-7 breast cancer cells changes estrogen receptor binding properties and commits cells to induce estrogenic responses. (7632613)
1995
45
Effects of the microtubule-disturbing agents docetaxel (Taxotere), vinblastine and vincristine on epidermal growth factor-receptor binding of human breast cancer cell lines in vitro. (7833145)
1994
46
Effects of a new synthetic vitamin D analogue, EB1089, on the oestrogen-responsive growth of human breast cancer cells. (8071654)
1994
47
Dose intensification of chemotherapy in advanced breast cancer: a feasibility phase II study. (7526508)
1994
48
72 KD and 92 KD type IV collagenase, type IV collagen, and laminin mRNAs in breast cancer: a study by in situ hybridization. (8014478)
1994
49
Determination of c-erbB-2 protein in primary breast cancer tissue extract using an enzyme immunoassay. (7904987)
1993
50
Age at first primary as a determinant of the incidence of bilateral breast cancer. Cumulative and relative risks in a population-based case-control study. (3965112)
1985

Genetic Variations for Breast Cancer

Expression for genes affiliated with Breast Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Breast Cancer

Search GEO for disease gene expression data for Breast Cancer.

Pathways for genes affiliated with Breast Cancer

Sources:
38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology, 52QIAGEN, 12EMD Millipore, 56SinoBiological, 54Reactome, 50PharmGKB
See all sources

Pathways related to Breast Cancer according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
112.8TP53, BRCA1, XRCC3, PHB, ATM, NCOA3
212.0BRCA1, TFF1, ATM, CHEK2, ESR1, TP53
3
Hide members
11.8BRCA1, PPM1D, ATM, CHEK2, TP53
4
Hide members
11.8BRCA1, PPM1D, PHB, ATM, CHEK2
5
Hide members
11.8BRCA1, ATM, CHEK2, BARD1, TP53
611.8BRCA1, ATM, CHEK2, BARD1, TP53
7
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
11.8TP53, BARD1, CHEK2, ATM, BRCA1
811.8BRCA1, ATM, CHEK2, BARD1, TP53
9
Hide members
11.8ATM, NCOA3, CHEK2, HMMR, TP53
10
Hide members
11.8BRCA1, ATM, CHEK2, BARD1, ESR1
1111.5PPM1D, ATM, CHEK2, TP53
1211.5TP53, CHEK2, ATM, BRCA1
1311.5BRCA1, ATM, CHEK2, TP53
14
Cell cycle Cell cycle (generic schema)
Hide members
11.5ESR1, CHEK2, NCOA3, BRCA1
1511.5BRCA1, TFF1, NCOA3, ESR1
16
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
Hide members
11.3TP53, CHEK2, ATM
17
Hide members
11.3CHEK2, ATM, BRCA1
18
Hide members
11.3PALB2, ATM, BRCA1
1911.3TP53, ATM, BRCA1
2011.3BRCA1, ATM, TP53
21
Hide members
11.3BARD1, ATM, BRCA1
22
Hide members
11.3XRCC3, ABCG2, TP53
2311.3TP53, ESR1, ABCG2
24
Hide members
11.0CHEK2, ATM
2511.0CHEK2, TP53
2611.0TP53, PALB2
2711.0XRCC3, TP53
28
Hide members
11.0ATM, BRCA1

Compounds for genes affiliated with Breast Cancer

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 29IUPHAR, 2BitterDB, 24HMDB
See all sources

Compounds related to Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1camptothecin45 60 1114.8TP53, BRCA1, XRCC3, PHB, ATM, CHEK2
2doxorubicin45 50 1114.5ESR1, TP53, ABCG2, CHEK2, ATM, BRCA1
3genistein45 29 60 2 11 2417.5TFF1, BRCA1, ATM, CHEK2, ABCG2, ESR1
4cisplatin45 50 60 1115.5BRCA1, XRCC3, ATM, ABCG2, TP53, CHEK2
5progesterone45 60 29 11 2416.4BRCA1, NCOA3, ABCG2, TP53, TFF1, ESR1
6steroid4512.4ABCG2, PHB, ESR1, NCOA3, BRCA1, TFF1
7phosphatidylinositol4512.4CDS1, CHEK2, NCOA3, ATM, ABCG2, BRCA1
8hydroxyurea45 50 1114.2ATM, CHEK2, TP53, ABCG2, BRCA1
9mitomycin c4512.2BRCA1, XRCC3, ATM, ABCG2, TP53
10caffeine45 50 29 2 11 2417.2ATM, XRCC3, TP53, CHEK2, BRCA1
11etoposide45 50 60 1115.2ATM, BRCA1, CHEK2, ABCG2, TP53
12retinoic acid45 2413.2CHEK2, ESR1, NCOA3, TFF1, TP53, BRCA1
13paraffin4512.1TP53, ESR1, ATM, TFF1, BRCA1
14cycloheximide4512.0ESR1, BRCA1, NCOA3, TP53, TFF1
15bpde4512.0CHEK2, BRCA1, ATM, TP53
16aphidicolin4512.0BRCA1, ATM, TP53, CHEK2
17topotecan45 1113.0ATM, BRCA1, TP53, ABCG2
184-hydroxytamoxifen4511.9NCOA3, ESR1, BRCA1, TFF1
19gemcitabine45 50 1113.9TP53, ABCG2, CHEK2, BRCA1
20docetaxel45 50 60 1114.9ESR1, ABCG2, BRCA1, TP53
21cyclophosphamide45 50 1113.9TP53, ESR1, BRCA1, ABCG2
225fluorouracil4511.8BRCA1, ABCG2, ESR1, TP53
23retinoid4511.8TP53, ESR1, NCOA3, TFF1
24n acetylcysteine4511.7ATM, XRCC3, TP53, CHEK2
25testosterone45 60 11 2414.7NCOA3, ESR1, BRCA1, ABCG2, TFF1
26daidzein4511.7ESR1, TFF1, BRCA1
27naringenin45 1112.7ABCG2, ESR1, TFF1
28taxane4511.7TP53, ESR1, ABCG2
29sn 3845 6012.7ABCG2, TP53, CHEK2
30indole-3-carbinol4511.6ESR1, TP53, BRCA1
31diethylstilbestrol45 29 1113.6ABCG2, ESR1, TFF1
32paclitaxel45 50 1113.6ABCG2, ESR1, BRCA1, TP53
33benzo(a)pyrene4511.6TP53, ABCG2, BRCA1
34oxaliplatin45 50 1113.6TP53, ABCG2, BRCA1
35leptomycin b45 6012.5BRCA1, TP53, PHB
36carboplatin45 50 1113.4TP53, ABCG2, BRCA1
37tamoxifen45 50 29 1114.4NCOA3, TFF1
38bleomycin45 1112.4BRCA1, ATM, TP53
39adriamycin4511.4ABCG2, CHEK2
40arzoxifene4511.4TFF1, ESR1
41neocarzinostatin4511.4ATM, CHEK2
42equol4511.3TFF1, ESR1
43biochanin a4511.3ABCG2, TFF1
44nocodazole45 1112.3CHEK2, BRCA1, TP53
45cytarabine45 50 1113.3TP53, ABCG2, ATM
46nonylphenol4511.2TFF1, ESR1
47rapamycin4511.2ABCG2, CHEK2, NCOA3, ATM
48estrogen4511.2BARD1
49resveratrol45 60 11 2414.1TFF1
50estradiol45 11 2413.1NCOA3

GO Terms for genes affiliated with Breast Cancer

Products for genes affiliated with Breast Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Breast Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet