MCID: BRS047
MIFTS: 105

Breast Cancer malady

Cancer diseases, Genetic diseases categories

Summaries for Breast Cancer

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 21Genetics Home Reference, 45Novus Biologicals, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Breast cancer affects one in eight women during their lives. breast cancer kills more women in the united states than any cancer except lung cancer. no one knows why some women get breast cancer, but there are a number of risk factors. risks that you cannot change include age - the chance of getting breast cancer rises as a woman gets older genes - there are two genes, brca1 and brca2, that greatly increase the risk. women who have family members with breast or ovarian cancer may wish to be tested. personal factors - beginning periods before age 12 or going through menopause after age 55 other risks include being overweight, using hormone replacement therapy (also called menopausal hormone therapy), taking birth control pills, drinking alcohol, not having children or having your first child after age 35 or having dense breasts. symptoms of breast cancer may include a lump in the breast, a change in size or shape of the breast or discharge from a nipple. breast self-exam and mammography can help find breast cancer early when it is most treatable. treatment may consist of radiation, lumpectomy, mastectomy, chemotherapy and hormone therapy. men can have breast cancer, too, but the number of cases is small. nih: national cancer institute

MalaCards: Breast Cancer, also known as breast carcinoma, is related to male breast cancer and bilateral breast cancer. An important gene associated with Breast Cancer is CHEK2 (checkpoint kinase 2), and among its related pathways are Integrated Breast Cancer Pathway and DNA Damage. The drugs aminoglutethimide and chlorambucil and the compounds camptothecin and etoposide have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and lymph node, and related mouse phenotypes are mortality/aging and cellular.

Disease Ontology:8 A thoracic cancer that originates in the mammary gland.

CDC:3 Breast cancer is the most common cancer among American women. Having regular mammograms can lower the risk of dying from breast cancer. If you are 50 to 74 years old, be sure to have a screening mammogram every two years. If you are 40 to 49 years old, talk to your doctor about when to start and how often to get a screening mammogram.

Genetics Home Reference:21 Breast cancer is a disease in which certain cells in the breast become abnormal and multiply without control or order to form a tumor. The most common form of breast cancer begins in cells lining the ducts that carry milk to the nipple (ductal cancer). Other forms of breast cancer begin in the glands that produce milk (lobular cancer) or in other parts of the breast.

Novus Biologicals:45 Breast cancer is a malignant tumor that originates from breast tissue cells. Although most breast cancers initiate in the cells that line the breast ducts, some begin in the breast lobules and other tissues. As with all cancers, there is a genetic and environmental component of developing breast cancer. Women with defects in the BRCA1 and BRCA2 genes have up to an 80% chance of getting breast cancer. Research has also found that defects in the ErbB-2 gene lead to increased levels of the protein cyclin D1. Cyclin D1 then activates CDK4, which causes proliferation of cellular division. Blocking CDK4 activity may lead to effective breast cancer treatments.

Wikipedia:63 Breast cancer is a type of cancer originating from breast tissue, most commonly from the inner lining of... more...

Description from OMIM:46 114480

Aliases & Classifications for Breast Cancer

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Sources:
8Disease Ontology, 9diseasecard, 63Wikipedia, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases


Aliases & Descriptions:

breast cancer 8 9 63 21 46 10 44 33
breast carcinoma 8 21 10 44 60
malignant neoplasm of breast 8 63 21
cancer of breast 63 22 21
mammary cancer 8 63 21
malignant tumor of breast 63 21
mammary tumor 8 44
malignant tumor of the breast 8
animal mammary neoplasms 60
carcinoma of male breast 60
carcinoma of breast nos 8
breast cancer, familial 21
primary breast cancer 8
carcinoma of breast 8
malignant neoplasms 60
male breast cancer 63
mammary carcinoma 8
mammary neoplasms 60
ca breast - nos 8
breast tumor 8


Related Diseases for Breast Cancer

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Breast Cancer family:

Inflammatory Breast Carcinoma Breast Benign Neoplasm
Breast Carcinoma in Situ Familial Breast Cancer
Chek2-Related Susceptibility to Breast Cancer Bard1-Related Susceptibility to Breast Cancer
Brip1-Related Breast Cancer Breast Cancer, Type 3
Breast Cancer, Early-Onset

Diseases related to Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1184)
idRelated DiseaseScoreTop Affiliating Genes
1male breast cancer31.9BRCA1, BRCA2, ESR1
2bilateral breast cancer31.6ESR1, RAD51, CHEK2, ATM, BRCA1, BRCA2
3ovarian cancer31.4TP53, ESR1, ABCG2, TFF1, BRCA2, BRCA1
4prostate cancer31.4PHB, TFF1, XRCC3, BRCA2, BRCA1, AKT1
5lung cancer31.4TFF1, ATM, CHEK2, ABCG2, TP53
6brain cancer31.2AKT1, ABCG2, RAD51, TP53
7ductal carcinoma in situ31.2BRCA1, BRCA2, ESR1, TP53
8leukemia31.2BRCA1, BRCA2, AKT1, ATM, CHEK2, ABCG2
9colorectal cancer31.1TP53, NBN, ATM, TFF1
10colon cancer31.0BRCA1, BRCA2, TFF1, AKT1, ATM, CHEK2
11retinoblastoma30.9BRCA1, BRCA2, PHB, AKT1, CHEK2, ABCG2
12melanoma30.9BRCA2, XRCC3, AKT1, ATM, CHEK2, ABCG2
13thyroid cancer30.9TP53, AKT1
14ataxia telangiectasia30.9BRCA1, BRCA2, XRCC3, ATM, CHEK2, RAD51
15sarcoma30.8TP53, CHEK2, BRCA2
16pancreatic cancer30.7ABCG2, ATM, AKT1, TFF1, BRCA2
17pancreatitis30.7BRCA2
18adenocarcinoma30.7BRCA1, BRCA2, XRCC3, TFF1, AKT1, CHEK2
19gynecomastia30.6BRCA1, BRCA2, ESR1
20cervical cancer30.6TP53
21li-fraumeni syndrome30.5ESR1
22stomach cancer30.5TFF1, AKT1, CHEK2, ABCG2, NBN, TP53
23osteosarcoma30.4CHEK2, ABCG2, ESR1, TP53
24meningioma30.4TFF1, ESR1
25lynch syndrome30.4BRCA2, BRCA1
26adenoma30.4BRCA1, XRCC3, TFF1, ATM, RAD51, TP53
27cowden disease30.3BRCA2, BRCA1
28nijmegen breakage syndrome30.3BRCA1, ATM, CHEK2, NBN
29xeroderma pigmentosum30.2BRCA1, XRCC3, TP53
30myeloma30.2HMMR, ABCG2, AKT1
31multiple myeloma30.2AKT1, TP53
32endometriosis30.2ESR1
33squamous cell carcinoma30.2XRCC3, TFF1, AKT1, CHEK2, ABCG2, NBN
34breast cancer, invasive ductal30.2BRCA1, TFF1, ATM, ESR1, TP53
35endometrial carcinoma30.2BRCA1, BRCA2, AKT1, ESR1, TP53
36neuroblastoma30.2TP53, AKT1
37kidney cancer30.1TP53
38glioblastoma multiforme30.0AKT1, ATM, CHEK2, ABCG2, TP53
39werner syndrome30.0NBN, ATM, BRCA1
40breast-ovarian cancer, familial, 230.0BRCA2
41fallopian tube cancer30.0BRCA1, BRCA2
42b-cell chronic lymphocytic leukemia30.0BRCA2, ATM, RAD51, TP53
43burkitt's lymphoma29.8BRCA2, AKT1, ATM, CHEK2, ABCG2, NBN
44cervical adenocarcinoma29.8ESR1
45bloom syndrome29.8BRCA1, BRCA2, ATM, RAD51
46medulloblastoma29.8TP53, AKT1, PPM1D, BRCA2
47fibrosarcoma29.8AKT1, ABCG2, RAD51, HMMR
48astrocytoma29.8TP53, AKT1, BRCA1
49fanconi's anemia29.8BRCA2, BRIP1, PALB2
50rhabdomyosarcoma29.8TP53, AKT1

Graphical network of the top 20 diseases related to Breast Cancer:



Diseases related to breast cancer

Clinical Features for Breast Cancer

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

114480

Drugs & Therapeutics for Breast Cancer

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Breast Cancer

Search NIH Clinical Center for Breast Cancer

Search CenterWatch for Breast Cancer

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Genetic Tests for Breast Cancer

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Sources:
22GTR
See all sources

Genetic tests related to Breast Cancer:

id Genetic test Affiliating Genes
1 Breast Cancer, Susceptibility to22
2 Neoplasm of Breast22

Anatomical Context for Breast Cancer

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Sources:
32MalaCards
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MalaCards organs/tissues related to Breast Cancer:

32
Breast, Bone, Lymph node, Prostate, Endothelial, Lung, Testes, Bone marrow, Brain, Colon, T cells, Liver, Thyroid, Skin, Myeloid, Monocytes, Ovary, Heart, Testis, Placenta, Pituitary, B cells, Cervix, Pancreas, Kidney, Uterus, Spleen, Smooth muscle, Adipocyte, Salivary gland, Pineal, Whole blood, Nk cells, Small intestine, Dentritic cells, Thymus, Eye, Hypothalamus, Trachea, Cortex, B lymphoblasts, Spinal cord

Animal Models for Breast Cancer or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Breast Cancer:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076814.0AKT1, PHB, PPM1D, BRCA2, BRCA1, ATM
2MP:000538413.8ATM, AKT1, PPM1D, BRCA2, BRCA1, CHEK2
3MP:000537813.8AKT1, PHB, PPM1D, BRCA2, BRCA1, ATM
4MP:000539713.1BRCA1, BRCA2, PPM1D, AKT1, ATM, CHEK2
5MP:001077112.9BRCA1, BRCA2, PPM1D, PHB, AKT1, ABCG2
6MP:000538712.8BRCA2, PPM1D, AKT1, ATM, CHEK2, ESR1
7MP:000537612.8BRCA1, BRCA2, PPM1D, TFF1, PHB, AKT1
8MP:000538912.8BRCA1, BRCA2, PPM1D, PHB, AKT1, HMMR
9MP:000200612.6PALB2, PPM1D, TFF1, AKT1, CHEK2, BARD1
10MP:000537912.4BRCA1, BRCA2, PPM1D, AKT1, ATM, NBN
11MP:000538011.2PALB2, BARD1
12MP:000363110.9BARD1, PALB2

Publications for Breast Cancer

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Sources:
50PubMed
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Articles related to Breast Cancer:

(show top 50)    (show all 23527)
idTitleAuthorsYear
1
Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. (23505378)
2013
2
Inhibition of human MCF-7 breast cancer cells and HT-29 colon cancer cells by rice-produced recombinant human insulin-like growth binding protein-3 (rhIGFBP-3). (24143239)
2013
3
The prevalence of BRCA mutations among familial breast cancer patients in Korea: results of the Korean Hereditary Breast Cancer study. (23131904)
2013
4
RGD binding to integrin alphavbeta3 affects cell motility and adhesion in primary human breast cancer cultures. (23181508)
2012
5
Time-course of arm lymphedema and potential risk factors for progression of lymphedema after breast conservation treatment for early stage breast cancer. (22487094)
2012
6
A role for XRCC2 gene polymorphisms in breast cancer risk and survival. (21632523)
2011
7
Estimating changes in overall survival using progression-free survival in metastatic breast and colorectal cancer. (21756410)
2011
8
Expression of deleted in liver cancer 1 and phosphorelated focal adhesion kinase in breast cancer]. (21868344)
2011
9
Cytoplasmic compartmentalization of SOX9 abrogates the growth arrest response of breast cancer cells that can be rescued by trichostatin A treatment. (21084857)
2011
10
Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells. (21542805)
2011
11
A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer. (20946665)
2010
12
Role for ezrin in breast cancer cell chemotaxis to CCL5. (20811677)
2010
13
Breast cancer brain metastases express the sodium iodide symporter. (19618116)
2010
14
Balance between SIRT1 and DBC1 expression is lost in breast cancer. (20412117)
2010
15
Inhibition of histone deacetylase suppresses EGF signaling pathways by destabilizing EGFR mRNA in ER-negative human breast cancer cells. (18683042)
2009
16
Production and characterisation of monoclonal antibodies against RAI3 and its expression in human breast cancer. (19552806)
2009
17
Genistein protects against polycyclic aromatic hydrocarbon-induced oxidative DNA damage in non-cancerous breast cells MCF-10A. (18570695)
2009
18
A positive feedback between activated extracellularly regulated kinase and cyclooxygenase/lipoxygenase maintains proliferation and migration of breast cancer cells. (19008312)
2009
19
Clinicopathological relevance of UbcH10 in breast cancer. (19038004)
2009
20
The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms. (18097747)
2008
21
Body mass index and HER-2 overexpression in breast cancer patients over 50 years of age. (17211534)
2007
22
Breast cancer risk and polymorphisms in genes involved in metabolism of estrogens (CYP17, HSD17beta1, COMT and MnSOD): possible protective role of MnSOD gene polymorphism Val/Ala and Ala/Ala in women that never breast fed. (16969494)
2006
23
On the proposed association of the ATM variants 5557G>A and IVS38-8T>C and bilateral breast cancer. (16496408)
2006
24
Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells. (16740734)
2006
25
Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells. (16679312)
2006
26
Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer. (15837987)
2005
27
Bone marrow stromal cell-derived growth inhibitor inhibits growth and migration of breast cancer cells via induction of cell cycle arrest and apoptosis. (15569677)
2005
28
Differential regulation of somatostatin receptors 1 and 2 mRNA and protein expression by tamoxifen and estradiol in breast cancer cells. (16018813)
2005
29
High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer. (15534085)
2004
30
The significance of Fas/FasL molecular system in breast cancer]. (15688829)
2004
31
Expression of survivin in different stages of carcinogenesis and progression of breast cancer]. (15191674)
2004
32
The favorable prognostic impact of tissue inhibitor of matrix metalloproteinases-1 protein overexpression in breast cancer cells. (14629269)
2003
33
Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression. (12618881)
2003
34
Phase II study of concurrent administration of doxorubicin and docetaxel as first-line chemotherapy for metastatic breast cancer. (12566909)
2003
35
A low frequency of non-founder BRCA1 mutations in Ashkenazi Jewish breast-ovarian cancer families. (12402332)
2002
36
Normal breast epithelial cells induce apoptosis of breast cancer cells via Fas signaling. (11925103)
2002
37
The antiproliferative activity of resveratrol results in apoptosis in MCF-7 but not in MDA-MB-231 human breast cancer cells: cell-specific alteration of the cell cycle. (12392819)
2002
38
Re: Randomized trial of a specialist genetic assessment service for familial breast cancer. (11208894)
2001
39
Quantitative RT-PCR luminometric hybridization assay with an RNA internal standard for cytokeratin-19 mRNA in peripheral blood of patients with breast cancer. (11849626)
2001
40
HER-2/neu amplification in benign breast disease and the risk of subsequent breast cancer. (10637239)
2000
41
Transcriptional suppression of synuclein gamma (SNCG) expression in human breast cancer cells by the growth inhibitory cytokine oncostatin M. (11016747)
2000
42
Modulating effect of vitamin D3 in vitro on EGFR mRNA expression of human breast cancer cell lines]. (11778232)
2000
43
The risk of premature menopause induced by chemotherapy for early breast cancer. (10534297)
1999
44
Alcohol dehydrogenase 3 genotype modification of the association of alcohol consumption with breast cancer risk. (10530606)
1999
45
The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer. (10070957)
1999
46
bcl-2 protein expression is associated with a prognostically favourable phenotype in breast cancer irrespective of p53 immunostaining. (10231398)
1999
47
Efficacy of epirubicin/paclitaxel combination in mobilizing large amounts of hematopoietic progenitor cells in patients with metastatic breast cancer showing optimal response to the same chemotherapy regimen. (10509041)
1999
48
A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families. (8554067)
1996
49
Clinical and endocrine effects of the oral aromatase inhibitor vorozole in postmenopausal patients with advanced breast cancer. (7954417)
1994
50
Cathepsin D as a prognostic indicator for node-negative breast cancer patients using both immunoassays and enzymatic assays. (1394123)
1992

Genetic Variations for Breast Cancer

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Sources:
62UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Breast Cancer:

62 (show all 70)
id Symbol AA change Variation ID SNP ID
1AKT1p.Glu17LysVAR_055422rs121434592
2BRCA1p.Leu22SerVAR_007756
3BRCA1p.Cys61GlyVAR_007757rs28897672
4BRCA1p.Cys64GlyVAR_007758
5BRCA1p.Val271MetVAR_007761rs80357244
6BRCA1p.Phe461LeuVAR_007765rs56046357
7BRCA1p.Tyr465AspVAR_007766
8BRCA1p.Gly552ValVAR_007768
9BRCA1p.Leu892SerVAR_007775
10BRCA1p.Gly960AspVAR_007776
11BRCA1p.Thr1025IleVAR_007778
12BRCA1p.Val1047AlaVAR_007781
13BRCA1p.Pro1150SerVAR_007782rs80357272
14BRCA1p.Ala1708GluVAR_007796rs28897696
15BRCA1p.Met1775ArgVAR_007799
16BRCA1p.Glu10LysVAR_020679
17BRCA1p.Glu23LysVAR_020680
18BRCA1p.Asp749TyrVAR_020683
19BRCA1p.Ser1187IleVAR_020690
20BRCA1p.Gln1200HisVAR_020691rs56214134
21BRCA1p.Arg1204IleVAR_020692
22BRCA1p.Lys1207AsnVAR_020693
23BRCA1p.Ser1217TyrVAR_020695
24BRCA1p.Arg1699TrpVAR_020703
25BRCA1p.Met1775LysVAR_063212
26BRCA2p.Phe32LeuVAR_005085
27BRCA2p.Lys53ArgVAR_005086
28BRCA2p.Phe81LeuVAR_005088
29BRCA2p.Pro201ArgVAR_005089
30BRCA2p.Val211AlaVAR_005090
31BRCA2p.Pro222SerVAR_005091
32BRCA2p.Cys554TrpVAR_005095
33BRCA2p.Asp728AlaVAR_005097
34BRCA2p.Gly2274ValVAR_005105
35BRCA2p.His2415AsnVAR_005106
36BRCA2p.Gln2421HisVAR_005107
37BRCA2p.Met3118ThrVAR_005110
38BRCA2p.Thr3357ArgVAR_005111
39BRCA2p.Glu2089AspVAR_008783
40BRCA2p.Thr2722ArgVAR_018661
41BRCA2p.Ser1179AsnVAR_020715
42BRCA2p.Cys1580TyrVAR_020719
43BRCA2p.Thr1679IleVAR_020720
44BRCA2p.Val1804AlaVAR_020721
45BRCA2p.Glu1901LysVAR_020722
46BRCA2p.Ser2072CysVAR_020725
47BRCA2p.Tyr2094CysVAR_020726
48BRCA2p.Pro2096LeuVAR_020727
49BRCA2p.Lys2128AsnVAR_020729
50BRCA2p.Val2728IleVAR_020736rs28897749
51BRCA2p.Lys2729AsnVAR_020737rs80359065
52BRCA2p.Asn3124IleVAR_020743
53BRCA2p.Lys3196GluVAR_020744rs80359228
54BRCA2p.Gly25ArgVAR_028167
55BRCA2p.Trp31CysVAR_028168
56BRCA2p.Trp31ArgVAR_028169
57BRCA2p.Thr64IleVAR_032712
58BRCA2p.Ser326ArgVAR_032717rs28897706
59BRCA2p.Ile505ThrVAR_032718rs28897708
60BRCA2p.Ile729MetVAR_032719
61BRCA2p.Lys1690AsnVAR_032722
62BRCA2p.Asn1730TyrVAR_032723
63BRCA2p.Thr1887MetVAR_032724
64BRCA2p.Asn2135HisVAR_032728
65BRCA2p.Tyr2222CysVAR_032729
66BRCA2p.Gln2456GluVAR_032731
67BRIP1p.Pro47AlaVAR_020896rs28903098
68BRIP1p.Met299IleVAR_020900
69NBNp.Leu150PheVAR_025795
70RAD51p.Arg150GlnVAR_010899rs121917739

Expression for genes affiliated with Breast Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Breast Cancer

Search GEO for disease gene expression data for Breast Cancer.

Pathways for genes affiliated with Breast Cancer

About this section
Sources:
37NCBI BioSystems Database, 4Cell Signaling Technology, 12EMD Millipore, 29KEGG, 51QIAGEN, 53Reactome, 59Tocris Bioscience, 55SinoBiological, 49PharmGKB
See all sources

Pathways related to Breast Cancer according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
113.4TP53, BRCA1, BRCA2, ESR1, RAD51, BARD1
2
Hide members
12.8BRCA1, BRCA2, BRIP1, PPM1D, PHB, ATM
3
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
12.8NBN, RAD51, BARD1, CHEK2, ATM, BRIP1
412.8BRCA1, BRCA2, TFF1, AKT1, ATM, CHEK2
5
Hide members
12.3BRCA1, PPM1D, ATM, CHEK2, RAD51, NBN
612.3BRCA1, BRCA2, ATM, CHEK2, BARD1, RAD51
7
Hide members
12.3BRCA1, BRCA2, ATM, CHEK2, BARD1, RAD51
8
Hide members
12.3BRCA1, AKT1, ATM, CHEK2, RAD51, ESR1
9
Hide members
12.0BRCA1, AKT1, ATM, CHEK2, BARD1, TP53
1012.0BRCA1, ATM, CHEK2, BARD1, NBN, TP53
11
Hide members
12.0BRCA1, BRCA2, ATM, RAD51, PALB2, NBN
1211.8PPM1D, AKT1, ATM, CHEK2, TP53
13
Hide members
11.8AKT1, ATM, CHEK2, HMMR, TP53
1411.8BRCA1, ATM, CHEK2, RAD51, TP53
15
Hide members
11.8BRCA1, BRCA2, ATM, BARD1, RAD51
16
Hide members
11.8BRCA1, BRCA2, AKT1, ATM, TP53
1711.8BRCA1, BRCA2, BRIP1, RAD51, PALB2
18
Hide members
11.8BRCA2, XRCC3, ATM, RAD51, NBN
19
Hide members
11.8BRCA1, BRCA2, ATM, RAD51, NBN
20
Hide members
11.8BRCA1, BRCA2, ATM, RAD51, NBN
21
Hide members
11.8TP53, ESR1, AKT1, BRCA2, BRCA1
2211.5BRCA1, ATM, CHEK2, TP53
23
Hide members
11.5AKT1, ATM, CHEK2, TP53
2411.5AKT1, ATM, CHEK2, TP53
25
Cell cycle Role of 14-3-3 proteins in cell cycle regulation
Hide members
11.5AKT1, ATM, CHEK2, TP53
26
Hide members
11.5CHEK2, ATM, AKT1, BRCA1
27
Cell cycle Cell cycle (generic schema)
Hide members
11.5BRCA1, AKT1, CHEK2, ESR1
28
Hide members
11.5BRCA2, AKT1, RAD51, TP53
2911.5AKT1, ATM, ESR1, NBN
3011.3TP53, ATM, BRCA1
3111.3BRCA1, ATM, TP53
3211.3TP53, CHEK2, AKT1
33
Hide members
11.3TP53, NBN, PALB2
34
Hide members
11.3AKT1, ATM, TP53
3511.3BRCA2, CHEK2, ESR1
3611.3BRCA1, AKT1, TP53
37
Hide members
11.3NBN, ATM, BRCA1
38
Hide members
11.3TP53, ABCG2, XRCC3
3911.3TP53, ESR1, ABCG2
4011.3ESR1, TFF1, BRCA1
41
Hide members
11.0CHEK2, ATM
4211.0CHEK2, TP53
4311.0TP53, XRCC3
44
Hide members
11.0RAD51, BRCA2

Compounds for genes affiliated with Breast Cancer

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR, 2BitterDB, 24HMDB
See all sources

Compounds related to Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1camptothecin44 59 1115.5BRCA1, BRCA2, XRCC3, PHB, ATM, CHEK2
2etoposide44 49 59 1116.3BRCA1, ATM, RAD51, NBN, TP53, ABCG2
3cisplatin44 49 59 1116.3ATM, BRCA1, BRCA2, ABCG2, CHEK2, RAD51
4hydroxyurea44 49 1115.0RAD51, BRCA1, BRCA2, ATM, TP53, NBN
5mitomycin c4413.0NBN, BRCA2, XRCC3, ATM, ABCG2, TP53
6doxorubicin44 49 1115.0NBN, AKT1, ATM, BRCA1, CHEK2, TP53
7genistein44 28 59 2 11 2418.0TFF1, BRCA2, BRCA1, ABCG2, ATM, CHEK2
8phosphatidylinositol4413.0BRCA1, CHEK2, NBN, ABCG2, CDS1, ATM
9paclitaxel44 49 1114.7RAD51, TP53, ESR1, BRCA2, BRCA1, ABCG2
10paraffin4412.7TFF1, ESR1, TP53, ATM, AKT1, BRCA2
11cycloheximide4412.7BRCA2, AKT1, RAD51, TFF1, ESR1, TP53
12threonine4412.6AKT1, NBN, ATM, RAD51, ABCG2, PPM1D
13retinoic acid44 2413.5AKT1, BRCA1, TP53, BRCA2, TFF1, CHEK2
14gemcitabine44 49 1114.5RAD51, BRCA1, AKT1, CHEK2, ABCG2, TP53
15caffeine44 49 28 2 11 2417.5CHEK2, ATM, XRCC3, BRCA1, RAD51, TP53
16n acetylcysteine4412.4NBN, CHEK2, AKT1, TP53, XRCC3, ATM
17progesterone44 59 28 11 2416.3TP53, ESR1, ABCG2, TFF1, BRCA1, BRCA2
18aphidicolin4412.2BRCA1, CHEK2, TP53, RAD51, ATM
19indole-3-carbinol4412.2AKT1, ESR1, TP53, BRCA2, BRCA1
20methylmethanesulfonate4412.2BRCA1, BRCA2, RAD51, NBN, TP53
21testosterone44 59 11 2415.2ESR1, ABCG2, TFF1, AKT1, BRCA2, BRCA1
224-hydroxytamoxifen4412.2ESR1, AKT1, BRCA1, BRCA2, TFF1
23vincristine44 49 1114.2TP53, BRCA2, AKT1, ABCG2, BRCA1
24docetaxel44 49 59 1115.2TP53, ABCG2, BRCA1, BRCA2, ESR1
25polyacrylamide4412.1BRCA2, TFF1, RAD51, ATM, BRCA1
26rapamycin4412.1CHEK2, NBN, ABCG2, ATM, AKT1
27steroid4412.0PHB, ESR1, ABCG2, TFF1, BRCA2, BRCA1
28oligonucleotide4412.0ABCG2, TP53, RAD51, CHEK2, BRCA1, BRCA2
29ly2940024412.0ABCG2, TP53, ESR1, ATM, AKT1
30wortmannin4412.0AKT1, RAD51, ABCG2, CHEK2, ATM
31bpde4411.9CHEK2, TP53, ATM, BRCA1
32daidzein4411.9BRCA1, BRCA2, TFF1, ESR1
33topotecan44 1112.9ABCG2, ATM, BRCA1, TP53
34gefitinib44 49 1113.9AKT1, ESR1, RAD51, ABCG2
35bleomycin44 1112.9BRCA2, TP53, ATM, BRCA1
36nocodazole44 1112.8TP53, BRCA1, AKT1, CHEK2
37adriamycin4411.7ABCG2, CHEK2, AKT1
38mg 13244 5912.6ESR1, AKT1, BRCA1, TP53
39naringenin44 1112.6TFF1, ABCG2, ESR1
40cyclophosphamide44 49 1113.6ABCG2, ESR1, TP53, BRCA1
41taxane4411.6ABCG2, ESR1, TP53
42sn 3844 5912.6CHEK2, ABCG2, TP53
43o6-methylguanine4411.6RAD51, TP53, BRCA2
44h2o24411.5RAD51, AKT1, TFF1
45tamoxifen44 49 28 1114.4AKT1, TFF1
46resveratrol44 59 11 2414.4BRCA2, TFF1
47arzoxifene4411.2ESR1, TFF1
48estrogen4411.2BARD1
49neocarzinostatin4410.9ATM, CHEK2
50estradiol44 11 2412.4BRCA2

GO Terms for genes affiliated with Breast Cancer

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Sources:
16Gene Ontology
See all sources

Cellular components related to Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565413.5TP53, BRCA1, BRCA2, PHB, AKT1, ATM
2nucleusGO:00563413.3BRCA1, BRCA2, BRIP1, XRCC3, PPM1D, PHB
3PML bodyGO:01660511.6CHEK2, RAD51, NBN, TP53
4BRCA1-BARD1 complexGO:03143611.0BRCA1, BARD1
5replication forkGO:00565711.0TP53, NBN
6BRCA1-A complexGO:07053110.9BARD1, BRCA1

Biological processes related to Breast Cancer according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1double-strand break repairGO:00630212.9TP53, BRCA1, BRCA2, BRIP1, ATM, CHEK2
2DNA repairGO:00628112.9BRCA1, BRCA2, XRCC3, ATM, BARD1, RAD51
3response to DNA damage stimulusGO:00697412.6BRCA1, XRCC3, ATM, CHEK2, BARD1, RAD51
4double-strand break repair via homologous recombinationGO:00072412.4BRCA1, BRCA2, ATM, RAD51, PALB2, NBN
5positive regulation of transcription, DNA-dependentGO:04589311.9BRCA1, BRCA2, PHB, CHEK2, TP53
6negative regulation of apoptotic processGO:04306611.9TP53, PALB2, BARD1, ATM, AKT1
7cell cycle arrestGO:00705011.8TP53, NBN, BARD1, ATM
8regulation of apoptotic processGO:04298111.7TP53, ESR1, PHB, BRCA1
9replicative senescenceGO:09039911.6TP53, CHEK2, ATM
10DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697811.6BRCA1, BRCA2, TP53
11intrinsic apoptotic signaling pathway in response to DNA damageGO:00863011.5CHEK2, ATM, BRCA1
12response to gamma radiationGO:01033211.5BRCA2, CHEK2, TP53
13positive regulation of apoptotic processGO:04306511.5AKT1, ATM, BARD1, TP53
14DNA damage checkpointGO:00007711.5NBN, CHEK2, BRIP1
15somitogenesisGO:00175611.5ATM, PALB2, TP53
16DNA damage induced protein phosphorylationGO:00697511.2ATM, CHEK2
17protein K6-linked ubiquitinationGO:08502011.1BARD1, BRCA1
18positive regulation of nitric-oxide synthase activityGO:05100011.0ESR1, AKT1
19inner cell mass cell proliferationGO:00183310.9PALB2, BRCA2
20DNA damage response, signal transduction by p53 class mediatorGO:03033010.7TP53, NBN

Molecular functions related to Breast Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551515.1TP53, BRCA1, BRCA2, BRIP1, XRCC3, PPM1D
2ATP bindingGO:00552412.7BRIP1, XRCC3, AKT1, ATM, CHEK2, ABCG2
3identical protein bindingGO:04280211.7AKT1, CHEK2, RAD51, ESR1, TP53
4damaged DNA bindingGO:00368411.3RAD51, NBN, TP53
5protein N-terminus bindingGO:04748511.3TP53, NBN, ATM
6enzyme bindingGO:01989911.2TP53, ESR1, AKT1, BRCA1
7nitric-oxide synthase regulator activityGO:03023511.0ESR1, AKT1

Products for genes affiliated with Breast Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Breast Cancer

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet