MCID: BRS069
MIFTS: 37

Breast Cancer, Somatic malady

Cancer diseases category

Summaries for Breast Cancer, Somatic

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46OMIM, 32MalaCards
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MalaCards: Breast Cancer, Somatic is related to breast cancer and glioblastoma multiforme. An important gene associated with Breast Cancer, Somatic is RB1CC1 (RB1-inducible coiled-coil 1), and among its related pathways are Tie2 Signaling and G-protein signaling K-RAS regulation pathway. The compounds crcs and erlotinib have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are embryogenesis and cardiovascular system.

Description from OMIM:46 114480

Aliases & Classifications for Breast Cancer, Somatic

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46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

breast cancer, somatic 46


Related Diseases for Breast Cancer, Somatic

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17GeneCards, 18GeneDecks
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Diseases related to Breast Cancer, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.8KRAS, AKT1, PIK3CA, BRCA1, TSG101
2glioblastoma multiforme30.1PIK3CA, AKT1
3sporadic breast cancer10.2
4male breast cancer10.1
5sarcoma10.0KRAS
6neurofibromatosis10.0KRAS
7hepatitis c10.0KRAS
8thymoma10.0AKT1
9alzheimer's disease10.0AKT1
10pancreatitis10.0KRAS
11hyperglycemia10.0AKT1
12ductal carcinoma in situ10.0BRCA1
13myelodysplastic syndromes10.0KRAS
14bilateral breast cancer10.0BRCA1
15ovarian cancer, somatic10.0PIK3CA, AKT1
16colorectal cancer, somatic10.0PIK3CA, AKT1
17cowden disease10.0PIK3CA, BRCA1
18ataxia telangiectasia10.0BRCA1, PIK3CA
19adenoma10.0KRAS, BRCA1
20cervical cancer10.0TSG101, KRAS, PIK3CA
21lynch syndrome10.0KRAS, BRCA1
22lung cancer10.0AKT1, PIK3CA, KRAS
23thyroid cancer10.0PIK3CA, AKT1
24autosomal dominant disease10.0BRCA1, AKT1
25stomach cancer10.0KRAS, AKT1, PIK3CA
26cystadenoma10.0BRCA1, KRAS
27bladder carcinoma10.0BRCA1, PIK3CA, KRAS
28non-small cell lung carcinoma10.0KRAS, PIK3CA, AKT1
29astrocytoma10.0PIK3CA, BRCA1, AKT1
30hypertrophy of breast10.0BRCA1, AKT1, PIK3CA
31ovarian cancer10.0BRCA1, PIK3CA, KRAS, TSG101
32endometrial carcinoma10.0KRAS, AKT1, BRCA1, PIK3CA
33pancreatic cancer10.0PIK3CA, KRAS, BRCA1, AKT1
34adenocarcinoma10.0PIK3CA, KRAS, AKT1, BRCA1
35retinoblastoma10.0BRCA1, RB1CC1, AKT1, PIK3CA, KRAS
36prostate cancer10.0PIK3CA, AKT1, KRAS, TSG101, BRCA1
37colon cancer10.0KRAS, PIK3CA, AKT1, BRCA1

Graphical network of the top 20 diseases related to Breast Cancer, Somatic:



Diseases related to breast cancer, somatic

Clinical Features for Breast Cancer, Somatic

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Sources:
46OMIM
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Clinical features from OMIM:

114480

Drugs & Therapeutics for Breast Cancer, Somatic

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Breast Cancer, Somatic

Drug clinical trials:

Search ClinicalTrials for Breast Cancer, Somatic

Search NIH Clinical Center for Breast Cancer, Somatic

Search CenterWatch for Breast Cancer, Somatic

Genetic Tests for Breast Cancer, Somatic

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Anatomical Context for Breast Cancer, Somatic

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32MalaCards
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MalaCards organs/tissues related to Breast Cancer, Somatic:

32
Breast

Animal Models for Breast Cancer, Somatic or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Breast Cancer, Somatic:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053809.8TSG101
2MP:00053857.8KRAS, AKT1, RB1CC1, PIK3CA, BRCA1
3MP:00020067.7BRCA1, PIK3CA, TSG101, KRAS, AKT1
4MP:00028737.7BRCA1, RB1CC1, AKT1, KRAS, TSG101
5MP:00053797.7PIK3CA, TSG101, KRAS, AKT1, BRCA1
6MP:00053877.6AKT1, KRAS, PIK3CA, RB1CC1, BRCA1
7MP:00053787.5TSG101, KRAS, BRCA1, AKT1, PIK3CA
8MP:00107717.3AKT1, TSG101, KRAS, BRCA1, PIK3CA, RB1CC1
9MP:00053847.3PIK3CA, RB1CC1, AKT1, KRAS, TSG101, BRCA1
10MP:00107687.1TSG101, KRAS, AKT1, RB1CC1, PIK3CA, BRCA1

Publications for Breast Cancer, Somatic

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Genetic Variations for Breast Cancer, Somatic

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Breast Cancer, Somatic:

62 (show all 70)
id Symbol AA change Variation ID SNP ID
1AKT1p.Glu17LysVAR_055422rs121434592
2BRCA1p.Leu22SerVAR_007756
3BRCA1p.Cys61GlyVAR_007757rs28897672
4BRCA1p.Cys64GlyVAR_007758
5BRCA1p.Val271MetVAR_007761rs80357244
6BRCA1p.Phe461LeuVAR_007765rs56046357
7BRCA1p.Tyr465AspVAR_007766
8BRCA1p.Gly552ValVAR_007768
9BRCA1p.Leu892SerVAR_007775
10BRCA1p.Gly960AspVAR_007776
11BRCA1p.Thr1025IleVAR_007778
12BRCA1p.Val1047AlaVAR_007781
13BRCA1p.Pro1150SerVAR_007782rs80357272
14BRCA1p.Ala1708GluVAR_007796rs28897696
15BRCA1p.Met1775ArgVAR_007799
16BRCA1p.Glu10LysVAR_020679
17BRCA1p.Glu23LysVAR_020680
18BRCA1p.Asp749TyrVAR_020683
19BRCA1p.Ser1187IleVAR_020690
20BRCA1p.Gln1200HisVAR_020691rs56214134
21BRCA1p.Arg1204IleVAR_020692
22BRCA1p.Lys1207AsnVAR_020693
23BRCA1p.Ser1217TyrVAR_020695
24BRCA1p.Arg1699TrpVAR_020703
25BRCA1p.Met1775LysVAR_063212
26BRCA2p.Phe32LeuVAR_005085
27BRCA2p.Lys53ArgVAR_005086
28BRCA2p.Phe81LeuVAR_005088
29BRCA2p.Pro201ArgVAR_005089
30BRCA2p.Val211AlaVAR_005090
31BRCA2p.Pro222SerVAR_005091
32BRCA2p.Cys554TrpVAR_005095
33BRCA2p.Asp728AlaVAR_005097
34BRCA2p.Gly2274ValVAR_005105
35BRCA2p.His2415AsnVAR_005106
36BRCA2p.Gln2421HisVAR_005107
37BRCA2p.Met3118ThrVAR_005110
38BRCA2p.Thr3357ArgVAR_005111
39BRCA2p.Glu2089AspVAR_008783
40BRCA2p.Thr2722ArgVAR_018661
41BRCA2p.Ser1179AsnVAR_020715
42BRCA2p.Cys1580TyrVAR_020719
43BRCA2p.Thr1679IleVAR_020720
44BRCA2p.Val1804AlaVAR_020721
45BRCA2p.Glu1901LysVAR_020722
46BRCA2p.Ser2072CysVAR_020725
47BRCA2p.Tyr2094CysVAR_020726
48BRCA2p.Pro2096LeuVAR_020727
49BRCA2p.Lys2128AsnVAR_020729
50BRCA2p.Val2728IleVAR_020736rs28897749
51BRCA2p.Lys2729AsnVAR_020737rs80359065
52BRCA2p.Asn3124IleVAR_020743
53BRCA2p.Lys3196GluVAR_020744rs80359228
54BRCA2p.Gly25ArgVAR_028167
55BRCA2p.Trp31CysVAR_028168
56BRCA2p.Trp31ArgVAR_028169
57BRCA2p.Thr64IleVAR_032712
58BRCA2p.Ser326ArgVAR_032717rs28897706
59BRCA2p.Ile505ThrVAR_032718rs28897708
60BRCA2p.Ile729MetVAR_032719
61BRCA2p.Lys1690AsnVAR_032722
62BRCA2p.Asn1730TyrVAR_032723
63BRCA2p.Thr1887MetVAR_032724
64BRCA2p.Asn2135HisVAR_032728
65BRCA2p.Tyr2222CysVAR_032729
66BRCA2p.Gln2456GluVAR_032731
67BRIP1p.Pro47AlaVAR_020896rs28903098
68BRIP1p.Met299IleVAR_020900
69NBNp.Leu150PheVAR_025795
70RAD51p.Arg150GlnVAR_010899rs121917739

Expression for genes affiliated with Breast Cancer, Somatic

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Cancer, Somatic

Search GEO for disease gene expression data for Breast Cancer, Somatic.

Pathways for genes affiliated with Breast Cancer, Somatic

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 59Tocris Bioscience, 51QIAGEN, 49PharmGKB, 52R&D Systems
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Pathways related to Breast Cancer, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5KRAS, PIK3CA
29.5KRAS, PIK3CA
39.3AKT1, PIK3CA
4
G-protein signaling Cross-talk between Ras-family GTPases
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9.3PIK3CA, AKT1
59.3AKT1, PIK3CA
69.3AKT1, PIK3CA
79.3AKT1, PIK3CA
89.3AKT1, PIK3CA
99.3PIK3CA, AKT1
109.3AKT1, PIK3CA
119.3PIK3CA, AKT1
129.3PIK3CA, AKT1
139.3PIK3CA, AKT1
149.3PIK3CA, AKT1
159.3AKT1, PIK3CA
169.3PIK3CA, AKT1
179.3PIK3CA, AKT1
189.3AKT1, BRCA1
199.1PIK3CA, TSG101
209.0KRAS, PIK3CA, BRCA1
21
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8.9KRAS, PIK3CA, AKT1
22
Hide members
8.9PIK3CA, KRAS, AKT1
23
Translation Insulin regulation of translation
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8.9PIK3CA, KRAS, AKT1
248.9KRAS, PIK3CA, AKT1
25
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8.9PIK3CA, KRAS, AKT1
268.9KRAS, PIK3CA, AKT1
27
Hide members
8.9PIK3CA, KRAS, AKT1
28
Hide members
8.9KRAS, PIK3CA, AKT1
29
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8.9PIK3CA, KRAS, AKT1
30
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8.9KRAS, AKT1, PIK3CA
31
Development Prolactin receptor signaling
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8.9KRAS, AKT1, PIK3CA
328.9KRAS, AKT1, PIK3CA
33
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8.9AKT1, PIK3CA, KRAS
34
Hide members
8.9AKT1, PIK3CA, KRAS
35
Hide members
8.9PIK3CA, AKT1, KRAS
36
Hide members
8.9AKT1, PIK3CA, KRAS
37
Hide members
8.9AKT1, PIK3CA, KRAS
38
Development Endothelin-1/EDNRA signaling
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8.9PIK3CA, AKT1, KRAS
39
Hide members
8.9KRAS, AKT1, PIK3CA
408.9AKT1, PIK3CA, KRAS
41
Hide members
8.9AKT1, PIK3CA, KRAS
428.9KRAS, AKT1, BRCA1
43
Immune response IFN gamma signaling pathway
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8.8BRCA1, PIK3CA, AKT1
44
Hide members
8.8AKT1, PIK3CA, BRCA1
45
Hide members
8.4BRCA1, PIK3CA, AKT1, KRAS
46
Hide members
8.4KRAS, BRCA1, PIK3CA, AKT1
478.4AKT1, BRCA1, PIK3CA, KRAS
48
Hide members
8.1TSG101, AKT1, BRCA1, RB1CC1
498.1AKT1, PIK3CA, KRAS, TSG101
507.9AKT1, RB1CC1, PIK3CA, BRCA1, KRAS

Compounds for genes affiliated with Breast Cancer, Somatic

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Breast Cancer, Somatic according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1crcs449.8PIK3CA, KRAS
2erlotinib44 49 1111.7KRAS, PIK3CA
3farnesyl diphosphate44 28 1111.7KRAS, AKT1
4ptdins(3)p449.7AKT1, PIK3CA
5indole-3-carbinol449.6BRCA1, AKT1
6oxaliplatin44 49 1111.4KRAS, BRCA1
7l-nmma449.3AKT1, PIK3CA
85fluorouracil449.3BRCA1, PIK3CA, KRAS
94-hydroxytamoxifen449.3BRCA1, AKT1
10gefitinib44 49 1111.3KRAS, AKT1, PIK3CA
11rapamycin449.2KRAS, PIK3CA, AKT1
12ly294002449.2AKT1, PIK3CA, KRAS
13agar449.2PIK3CA, BRCA1, AKT1
14etoposide44 49 59 1112.1BRCA1, PIK3CA, AKT1
15wortmannin449.1KRAS, PIK3CA, AKT1
16tamoxifen44 49 28 1112.1BRCA1, AKT1, PIK3CA
17phosphoinositide449.1KRAS, PIK3CA, AKT1
18doxorubicin44 49 1111.1BRCA1, PIK3CA, AKT1
19paraffin449.1BRCA1, KRAS, AKT1
20metformin44 49 1111.0AKT1, PIK3CA
21genistein44 28 59 2 11 2414.0PIK3CA, AKT1, BRCA1
22gtp44 289.9KRAS, AKT1, PIK3CA
23vincristine44 49 1110.9BRCA1, AKT1, TSG101
24adriamycin448.9BRCA1, AKT1, TSG101
25paclitaxel44 49 1110.8BRCA1, KRAS, AKT1, PIK3CA
26cisplatin44 49 59 1111.7PIK3CA, BRCA1, AKT1, KRAS
27h2o2448.7KRAS, PIK3CA, AKT1, BRCA1
28vegf448.7PIK3CA, KRAS, AKT1, BRCA1
29phosphatidylinositol448.7BRCA1, PIK3CA, AKT1, KRAS
30retinoic acid44 249.7KRAS, PIK3CA, AKT1, BRCA1
31lipid448.5BRCA1, AKT1, PIK3CA, KRAS
32testosterone44 59 11 2411.4BRCA1, PIK3CA, AKT1, TSG101
33estrogen447.9KRAS, TSG101, PIK3CA, AKT1, BRCA1
34tyrosine447.9BRCA1, TSG101, KRAS, AKT1, PIK3CA

GO Terms for genes affiliated with Breast Cancer, Somatic

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16Gene Ontology
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Biological processes related to Breast Cancer, Somatic according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1striated muscle cell differentiationGO:0511469.6KRAS, AKT1
2positive regulation of nitric-oxide synthase activityGO:0510009.6KRAS, AKT1
3protein kinase B signaling cascadeGO:0434919.4AKT1, PIK3CA
4T cell costimulationGO:0312959.3AKT1, PIK3CA
5positive regulation of protein phosphorylationGO:0019349.2KRAS, AKT1, RB1CC1
6positive regulation of peptidyl-serine phosphorylationGO:0331389.2AKT1, PIK3CA
7insulin receptor signaling pathwayGO:0082869.1PIK3CA, AKT1, KRAS
8fibroblast growth factor receptor signaling pathwayGO:0085439.1KRAS, AKT1, PIK3CA
9Fc-epsilon receptor signaling pathwayGO:0380959.0PIK3CA, AKT1, KRAS
10epidermal growth factor receptor signaling pathwayGO:0071739.0KRAS, AKT1, PIK3CA
11neurotrophin TRK receptor signaling pathwayGO:0480118.9PIK3CA, AKT1, KRAS
12blood coagulationGO:0075968.6KRAS, AKT1, PIK3CA

Molecular functions related to Breast Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:0163019.0AKT1, PIK3CA
2protein bindingGO:0055157.1TSG101, KRAS, AKT1, RB1CC1, PIK3CA, BRCA1

Products for genes affiliated with Breast Cancer, Somatic

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Breast Cancer, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet