Breast Cancer, Somatic disease: drugs, articles, genes, clinical trials

Summaries for Breast Cancer, Somatic

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³³OMIM, ²²MalaCards
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MalaCards: Breast Cancer, Somatic, also known as breast carcinoma, is related to breast carcinoma and carcinoma. An important gene associated with Breast Cancer, Somatic is RB1CC1 (RB1-inducible coiled-coil 1), and among its related pathways are Immune response IFN gamma signaling pathway and EGFR Inhibitor Pathway, Pharmacodynamics. The compounds estrogen and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are muscle and cardiovascular system.

OMIM: 114480

Aliases & Descriptions for Breast Cancer, Somatic

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Sources:
⁴³UMLS, ³³OMIM
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breast cancer, somatic ³³

breast carcinoma ⁴³

Related Diseases for Breast Cancer, Somatic

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Sources:
¹³GeneCards, ¹⁴GeneDecks
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Diseases related to breast cancer, somatic by text searches and GeneDecks gene sharing:

(show top 50) (show all 187)

id	Related Disease	Score	Top Affiliating Genes
1	breast carcinoma	39.4	KRAS, AKT1, ATM, BRCA1, RB1CC1, PIK3CA
2	carcinoma	38.6	PIK3CA, RB1CC1, BRCA1, ATM, AKT1, KRAS
3	hypoxia	30.6	KRAS, AKT1, ATM, BRCA1, PIK3CA
4	ductal carcinoma in situ	29.9	PIK3CA, BRCA1, AKT1
5	retinoblastoma	29.7	KRAS, AKT1, BRCA1, RB1CC1, PIK3CA
6	breast cancer	29.6	KRAS, AKT1, ATM, BRCA1, RB1CC1, PIK3CA
7	ovarian carcinoma	28.0	PIK3CA, BRCA1, AKT1, KRAS
8	melanoma	27.7	KRAS, AKT1, ATM, BRCA1, PIK3CA
9	bilateral breast cancer	27.6	PIK3CA, BRCA1, ATM
10	breast-ovarian cancer	27.5	ATM, BRCA1, PIK3CA
11	ataxia	27.1	PIK3CA, BRCA1, ATM, AKT1
12	ataxia telangiectasia	26.9	AKT1, ATM, BRCA1, PIK3CA
13	adenocarcinoma	26.9	KRAS, AKT1, ATM, BRCA1, RB1CC1, PIK3CA
14	cowden disease	26.8	AKT1, BRCA1, PIK3CA
15	sporadic breast cancer	26.4	BRCA1, ATM, AKT1
16	gastric cancer	26.0	KRAS, AKT1, ATM, BRCA1, PIK3CA
17	pancreatitis	25.7	KRAS, AKT1, ATM, BRCA1, PIK3CA
18	medulloblastoma	25.7	PIK3CA, ATM, AKT1
19	prostate carcinoma	25.7	KRAS, AKT1, ATM, BRCA1, PIK3CA
20	cervical carcinoma	25.5	KRAS, AKT1, ATM, PIK3CA
21	multiple myeloma	25.4	PIK3CA, ATM, AKT1, KRAS
22	lung carcinoma	25.4	KRAS, AKT1, ATM, PIK3CA
23	myeloma	25.3	KRAS, AKT1, ATM, PIK3CA
24	fibrosis	24.8	AKT1, ATM, BRCA1, PIK3CA
25	sarcoma	24.7	PIK3CA, BRCA1, ATM, AKT1, KRAS
26	cervicitis	24.7	KRAS, AKT1, ATM, BRCA1, PIK3CA
27	ovarian cancer	24.7	KRAS, AKT1, ATM, BRCA1, PIK3CA
28	osteosarcoma	24.2	KRAS, AKT1, ATM, BRCA1, RB1CC1, PIK3CA
29	neuronitis	23.9	KRAS, AKT1, ATM, BRCA1, RB1CC1, PIK3CA
30	ovarian cancer, somatic	12.9	PIK3CA, AKT1
31	colorectal cancer, somatic	12.9	AKT1, PIK3CA
32	serous cystadenoma	12.9	BRCA1, KRAS
33	familial pancreatic cancer	12.9	BRCA1, KRAS
34	penile cancer	12.8	PIK3CA, KRAS
35	leopard syndrome	12.8	AKT1, PIK3CA
36	focal cortical dysplasia	12.8	PIK3CA, AKT1
37	lynch syndrome	12.7	KRAS, BRCA1
38	li-fraumeni syndrome	12.6	ATM, BRCA1
39	clear cell adenocarcinoma	12.5	PIK3CA, BRCA1
40	ampulla of vater carcinoma	12.5	PIK3CA, ATM
41	hereditary pancreatitis	12.4	BRCA1, ATM
42	neurofibromatosis	12.4	BRCA1, AKT1, KRAS
43	nijmegen breakage syndrome	12.4	BRCA1, ATM
44	endometrial adenocarcinoma	12.3	KRAS, AKT1, PIK3CA
45	skin cancer	12.3	AKT1, BRCA1, PIK3CA
46	noma	12.2	KRAS, AKT1, PIK3CA
47	oculomotor apraxia cogan type	12.2	PIK3CA, BRCA1, KRAS
48	gastric adenocarcinoma	12.2	KRAS, AKT1, PIK3CA
49	hypertrophy of breast	12.2	PIK3CA, BRCA1, AKT1
50	familial colorectal cancer	12.2	PIK3CA, KRAS

Graphical network of the top 20 diseases related to breast cancer, somatic:

Graphical network of diseases related to breast cancer, somatic

Clinical Features for Breast Cancer, Somatic

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Sources:
³³OMIM
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Clinical features from OMIM: 114480

Drugs & Therapeutics for Breast Cancer, Somatic

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Sources:
⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials
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Approved drugs:

Search CenterWatch for breast cancer, somatic

Drug clinical trials:

Search ClinicalTrials for breast cancer, somatic

Search NIH Clinical Center for breast cancer, somatic

Search CenterWatch for breast cancer, somatic

Genetic Tests for Breast Cancer, Somatic

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Anatomical Context for Breast Cancer, Somatic

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Sources:
²²MalaCards
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MalaCards organs/tissues related to breast cancer, somatic:

²²

Breast

Phenotypes for genes affiliated with Breast Cancer, Somatic

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²⁵MGI
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MGI Mouse Phenotypes related to breast cancer, somatic:

²⁵ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle phenotype	MP:0005369	8.2	AKT1, KRAS, BRCA1, RB1CC1, PIK3CA
2	cardiovascular system phenotype	MP:0005385	7.9	BRCA1, RB1CC1, PIK3CA, KRAS, AKT1
3	tumorigenesis	MP:0002006	7.8	AKT1, ATM, PIK3CA, KRAS, BRCA1
4	endocrine/exocrine gland phenotype	MP:0005379	7.7	PIK3CA, ATM, AKT1, KRAS, BRCA1
5	embryogenesis phenotype	MP:0005380	7.7	PIK3CA, KRAS, BRCA1, ATM, AKT1
6	hematopoietic system phenotype	MP:0005397	7.6	BRCA1, ATM, RB1CC1, KRAS, AKT1
7	reproductive system phenotype	MP:0005389	7.6	AKT1, ATM, PIK3CA, KRAS, BRCA1
8	nervous system phenotype	MP:0003631	7.5	PIK3CA, KRAS, BRCA1, ATM, AKT1
9	immune system phenotype	MP:0005387	7.4	ATM, KRAS, BRCA1, RB1CC1, PIK3CA, AKT1
10	cellular phenotype	MP:0005384	7.3	ATM, KRAS, RB1CC1, PIK3CA, BRCA1, AKT1
11	behavior/neurological phenotype	MP:0005386	7.2	PIK3CA, AKT1, ATM, BRCA1, KRAS
12	mortality/aging	MP:0010768	7.2	AKT1, KRAS, PIK3CA, RB1CC1, BRCA1, ATM

Publications for genes affiliated with Breast Cancer, Somatic

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³⁵PubMed
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Articles related to breast cancer, somatic:

id	Title	Authors	Year	Affiliating Genes
1	Two identical triplet sisters carrying a germline BRCA1 gene mutation acquire very similar breast cancer somatic mutations at multiple other sites throughout the genome. (10862044)	Wistuba I.I.... Gazdar A.F.	2000	BRCA1
2	Loss of heterozygosity at 11q23.1 and survival in breast cancer: results of a large European study. Breast Cancer Somatic Genetics Consortium. (10379867)	Laake K.... rresen-Dale A.L.	1999	ATM

Genes related to Breast Cancer, Somatic

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¹³GeneCards
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Genes related to breast cancer, somatic according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	RB1CC1	RB1-inducible coiled-coil 1	11.0
2	AKT1	v-akt murine thymoma viral oncogene homolog 1	11.0
3	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11.0
4	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	11.0
5	ATM	ataxia telangiectasia mutated	11.0	Publications
6	BRCA1	breast cancer 1, early onset	11.0	Publications

Expression for genes affiliated with Breast Cancer, Somatic

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¹BioGPS
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Expression patterns in normal tissues for genes affiliated with Breast Cancer, Somatic

Pathways for genes affiliated with Breast Cancer, Somatic

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Sources:
¹⁰EMD Millipore, ³⁴PharmGKB, ²⁰KEGG, ⁴¹Thomson Reuters, ³⁷R&D Systems, ³⁶QIAGEN
See all sources

Pathways related to breast cancer, somatic according to GeneDecks:

(show top 50) (show all 107)

id	Pathway	Score	Top Affiliating Genes
1	Immune response IFN gamma signaling pathway¹⁰	10.5	AKT1
2	EGFR Inhibitor Pathway, Pharmacodynamics³⁴	10.4	KRAS
3	Progesterone-mediated oocyte maturation²⁰	10.3	PIK3CA
4	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics³⁴	10.3	AKT1
5	Pathway_PA165959425³⁴	9.9	AKT1, KRAS
6	G-protein signaling Cross-talk between Ras-family GTPases¹⁰	9.7	PIK3CA, AKT1
7	G-protein signaling_Cross-talk between Ras-family GTPases⁴¹	9.7	AKT1, PIK3CA
8	Apoptosis and survival NGF signaling pathway¹⁰	9.7	AKT1, PIK3CA
9	IL-2 Signaling Pathways³⁷	9.7	AKT1, KRAS
10	Apoptosis and survival_NGF signaling pathway⁴¹	9.7	AKT1, PIK3CA
11	Insulin signaling pathway²⁰	9.7	PIK3CA, KRAS
12	Development EGFR signaling via PIP3¹⁰	9.7	PIK3CA, AKT1
13	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways³⁷	9.6	KRAS, AKT1
14	G-protein signaling_K-RAS regulation pathway⁴¹	9.6	KRAS, PIK3CA
15	Immune response_IL-10 signaling pathway⁴¹	9.6	AKT1, PIK3CA
16	G-protein signaling K-RAS regulation pathway¹⁰	9.6	PIK3CA, KRAS
17	DNA damage DNA-damage-induced responses¹⁰	9.5	BRCA1, ATM
18	Immune response IL-10 signaling pathway¹⁰	9.5	AKT1, PIK3CA
19	DNA damage_DNA-damage-induced responses⁴¹	9.5	ATM, BRCA1
20	Fanconis Anaemia Pathway³⁶	9.5	ATM, BRCA1
21	Cell cycle_Role of 14-3-3 proteins in cell cycle regulation⁴¹	9.5	AKT1, ATM
22	DNA Damage Induced 14-3-3Sigma Signaling³⁶	9.5	BRCA1, ATM
23	Cell cycle Role of 14-3-3 proteins in cell cycle regulation¹⁰	9.5	ATM, AKT1
24	Immune response IL-23 signaling pathway¹⁰	9.5	AKT1, PIK3CA
25	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1¹⁰	9.4	PIK3CA, AKT1
26	Sorafenib Pharmacodynamics³⁴	9.3	PIK3CA, AKT1, KRAS
27	Endometrial cancer²⁰	9.3	PIK3CA, AKT1, KRAS
28	Development VEGF signaling and activation¹⁰	9.3	BRCA1, AKT1, PIK3CA
29	Development_VEGF signaling and activation⁴¹	9.3	BRCA1, PIK3CA, AKT1
30	Non-small cell lung cancer²⁰	9.3	KRAS, AKT1, PIK3CA
31	Acute myeloid leukemia²⁰	9.3	PIK3CA, KRAS, AKT1
32	Immune response_IFN gamma signaling pathway⁴¹	9.3	AKT1, PIK3CA, BRCA1
33	Glioma²⁰	9.3	PIK3CA, AKT1, KRAS
34	Melanoma²⁰	9.3	KRAS, AKT1, PIK3CA
35	Chronic myeloid leukemia²⁰	9.3	PIK3CA, KRAS, AKT1
36	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR1⁴¹	9.3	AKT1, PIK3CA
37	B cell receptor signaling pathway²⁰	9.3	PIK3CA, AKT1, KRAS
38	VEGF signaling pathway²⁰	9.3	PIK3CA, AKT1, KRAS
39	Fc epsilon RI signaling pathway²⁰	9.3	KRAS, AKT1, PIK3CA
40	ErbB signaling pathway²⁰	9.3	PIK3CA, KRAS, AKT1
41	Prostate cancer²⁰	9.3	PIK3CA, AKT1, KRAS
42	T cell receptor signaling pathway²⁰	9.3	PIK3CA, AKT1, KRAS
43	Cholinergic synapse²⁰	9.3	PIK3CA, AKT1, KRAS
44	Neurotrophin signaling pathway²⁰	9.2	PIK3CA, AKT1, KRAS
45	Hepatitis C²⁰	9.2	PIK3CA, AKT1, KRAS
46	Chemokine signaling pathway²⁰	9.2	PIK3CA, KRAS, AKT1
47	IL-7 Signaling Pathways³⁷	9.2	AKT1, KRAS
48	GADD45 Pathway³⁶	9.1	BRCA1, ATM
49	p53 Signaling³⁶	9.1	AKT1, ATM, BRCA1
50	Apoptosis²⁰	9.0	AKT1, ATM, PIK3CA

Compounds for genes affiliated with Breast Cancer, Somatic

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Sources:
³²Novoseek , ⁴²Tocris Bioscience, ⁹DrugBank, ³⁴PharmGKB, ¹⁸HMDB
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Compounds related to breast cancer, somatic according to GeneDecks:

(show all 34)

id	Compound	Score	Top Affiliating Genes
1	estrogen³²	10.3	BRCA1
2	rapamycin³² ⁴²	10.9	KRAS, AKT1
3	farnesyl diphosphate³² ⁹ ⁹	11.7	AKT1, KRAS
4	ptdins(3)p³²	9.7	AKT1, PIK3CA
5	indole-3-carbinol³²	9.6	BRCA1, AKT1
6	crcs³²	9.4	KRAS, PIK3CA
7	bpde³²	9.4	BRCA1, ATM
8	erlotinib³² ³⁴ ⁹ ⁹	12.3	PIK3CA, KRAS
9	aphidicolin³²	9.3	ATM, BRCA1
10	gefitinib³² ³⁴ ⁹ ⁹	12.2	KRAS, PIK3CA, AKT1
11	oxaliplatin³² ³⁴ ⁹ ⁹	12.1	BRCA1, KRAS
12	agar³²	9.1	AKT1, PIK3CA, BRCA1
13	5fluorouracil³²	9.1	BRCA1, PIK3CA, KRAS
14	tamoxifen³² ³⁴ ⁹ ⁹	12.1	AKT1, PIK3CA, BRCA1
15	topotecan³² ⁹ ⁹	11.0	BRCA1, ATM
16	etoposide³² ⁴² ⁹ ⁹	12.0	AKT1, ATM, PIK3CA
17	ceramide³²	8.9	PIK3CA, ATM, AKT1
18	gtp³²	8.9	KRAS, PIK3CA, AKT1
19	polyacrylamide³²	8.9	KRAS, ATM, BRCA1
20	paclitaxel³² ³⁴ ⁹ ⁹	11.7	PIK3CA, BRCA1, AKT1, KRAS
21	h2o2³²	8.7	PIK3CA, KRAS, AKT1, BRCA1
22	vegf³²	8.6	KRAS, BRCA1, AKT1, PIK3CA
23	paraffin³²	8.5	BRCA1, AKT1, KRAS, ATM
24	retinoic acid³² ⁴² ¹⁸	10.5	KRAS, PIK3CA, BRCA1, AKT1
25	doxorubicin³² ³⁴ ⁹ ⁹	11.4	PIK3CA, AKT1, BRCA1, ATM
26	ly294002³²	8.4	AKT1, PIK3CA, ATM, KRAS
27	wortmannin³² ⁴²	9.4	PIK3CA, ATM, AKT1, KRAS
28	phosphoinositide³²	8.4	KRAS, PIK3CA, AKT1, ATM
29	genistein³² ⁹ ¹⁸ ⁹	11.4	BRCA1, ATM, AKT1, PIK3CA
30	cisplatin³² ³⁴ ⁹ ⁹	10.9	PIK3CA, BRCA1, ATM, AKT1, KRAS
31	phosphatidylinositol³²	7.9	KRAS, AKT1, PIK3CA, ATM, BRCA1
32	lipid³²	7.9	BRCA1, ATM, KRAS, AKT1, PIK3CA
33	serine³²	7.9	KRAS, PIK3CA, BRCA1, ATM, AKT1
34	tyrosine³²	7.8	ATM, KRAS, AKT1, BRCA1, PIK3CA

GO Terms for genes affiliated with Breast Cancer, Somatic

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¹²Gene Ontology
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Biological processes related to breast cancer, somatic according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	striated muscle cell differentiation	GO:051146	9.8	KRAS, AKT1
2	positive regulation of nitric-oxide synthase activity	GO:051000	9.7	AKT1, KRAS
3	protein kinase B signaling cascade	GO:043491	9.5	AKT1, PIK3CA
4	positive regulation of protein phosphorylation	GO:001934	9.4	RB1CC1, AKT1, KRAS
5	DNA damage response, signal transduction resulting in induction of apoptosis	GO:008630	9.3	ATM, BRCA1
6	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.3	AKT1, PIK3CA
7	G2/M transition DNA damage checkpoint	GO:031572	9.3	BRCA1, ATM
8	fibroblast growth factor receptor signaling pathway	GO:008543	9.2	AKT1, KRAS, PIK3CA
9	response to ionizing radiation	GO:010212	9.1	ATM, BRCA1
10	double-strand break repair	GO:006302	9.1	ATM, BRCA1
11	epidermal growth factor receptor signaling pathway	GO:007173	9.1	PIK3CA, AKT1, KRAS
12	insulin receptor signaling pathway	GO:008286	9.1	KRAS, AKT1, PIK3CA
13	nerve growth factor receptor signaling pathway	GO:048011	9.1	PIK3CA, AKT1, KRAS
14	negative regulation of apoptotic process	GO:043066	8.9	RB1CC1, ATM, AKT1
15	double-strand break repair via homologous recombination	GO:000724	8.8	ATM, BRCA1

Molecular functions related to breast cancer, somatic according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	kinase activity	GO:016301	9.3	AKT1, PIK3CA
2	1-phosphatidylinositol-3-kinase activity	GO:016303	9.0	ATM, PIK3CA
3	protein serine/threonine kinase activity	GO:004674	8.3	PIK3CA, AKT1, ATM
4	protein binding	GO:005515	7.1	BRCA1, RB1CC1, AKT1, KRAS, PIK3CA, ATM

Sources for Breast Cancer, Somatic

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¹BioGPS

²CDC

³Cell Signaling Technology

⁴CenterWatch

⁵ClinicalTrials

⁶Disease Ontology

⁷diseasecard

⁸DISEASES

⁹DrugBank

¹⁰EMD Millipore

¹¹FMA

¹²Gene Ontology

¹³GeneCards

¹⁴GeneDecks

¹⁵GeneReviews

¹⁶GeneTests

¹⁷Genetics Home Reference

¹⁸HMDB

¹⁹ICD9CM

²⁰KEGG

²¹LifeMap Discovery™

²²MalaCards

²³MedlinePlus

²⁴MeSH

²⁵MGI

²⁶NCBI Bookshelf

²⁷NCIt

²⁸NDF-RT

²⁹NIH Clinical Center

³⁰NIH Rare Diseases

³¹NINDS

³²Novoseek

³³OMIM

³⁴PharmGKB

³⁵PubMed

³⁶QIAGEN

³⁷R&D Systems

³⁸Reactome

³⁹SABiosciences

⁴⁰SNOMED-CT

⁴¹Thomson Reuters

⁴²Tocris Bioscience

⁴³UMLS

⁴⁴Wikipedia

MCID: BRS069	Breast Cancer, Somatic malady MalaCards information score (MIFTS): 43.0
6 genes, 1 tissue, 190 related diseases, 12 phenotypes, 2 articles, clinical trials.

Breast Cancer, Somatic malady

Summaries for Breast Cancer, Somatic

Aliases & Descriptions for Breast Cancer, Somatic

Related Diseases for Breast Cancer, Somatic

Diseases related to breast cancer, somatic by text searches and GeneDecks gene sharing:

Graphical network of the top 20 diseases related to breast cancer, somatic:

Clinical Features for Breast Cancer, Somatic

Drugs & Therapeutics for Breast Cancer, Somatic

Approved drugs:

Drug clinical trials:

Genetic Tests for Breast Cancer, Somatic

Anatomical Context for Breast Cancer, Somatic

MalaCards organs/tissues related to breast cancer, somatic:

Phenotypes for genes affiliated with Breast Cancer, Somatic

MGI Mouse Phenotypes related to breast cancer, somatic:

Publications for genes affiliated with Breast Cancer, Somatic

Articles related to breast cancer, somatic:

Genes related to Breast Cancer, Somatic

Genes related to breast cancer, somatic according to GeneCards:

Expression for genes affiliated with Breast Cancer, Somatic

Pathways for genes affiliated with Breast Cancer, Somatic

Pathways related to breast cancer, somatic according to GeneDecks:

Compounds for genes affiliated with Breast Cancer, Somatic

Compounds related to breast cancer, somatic according to GeneDecks:

GO Terms for genes affiliated with Breast Cancer, Somatic

Biological processes related to breast cancer, somatic according to GeneDecks:

Molecular functions related to breast cancer, somatic according to GeneDecks:

Sources for Breast Cancer, Somatic