MCID: BRS069
MIFTS: 33

Breast Cancer, Somatic malady

Cancer category

Summaries for Breast Cancer, Somatic

Sources:
47OMIM, 33MalaCards
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MalaCards: Breast Cancer, Somatic is related to sporadic breast cancer and male breast cancer. An important gene associated with Breast Cancer, Somatic is RB1CC1 (RB1-inducible coiled-coil 1), and among its related pathways are Tie2 Signaling and G-protein signaling K-RAS regulation pathway. The compounds fpa 124 and 10-debc hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include breast and prostate, and related mouse phenotypes are embryogenesis and reproductive system.

Description from OMIM:47 114480

Aliases & Classifications for Breast Cancer, Somatic

Sources:
47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

breast cancer, somatic 47


Related Diseases for Breast Cancer, Somatic

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Breast Cancer, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1sporadic breast cancer10.4
2male breast cancer10.1
3sarcoma10.0KRAS
4myelodysplastic syndromes10.0KRAS
5hepatitis c10.0KRAS
6neurofibromatosis10.0KRAS
7pancreatitis10.0KRAS
8thymoma10.0AKT1
9skin cancer10.0AKT1
10multiple myeloma10.0AKT1
11herpes simplex10.0ATM
12ductal carcinoma in situ10.0BRCA1
13myeloma10.0AKT1, IGH
14schizophrenia10.0AKT1, IGH
15cowden disease10.0PIK3CA, BRCA1
16cervical cancer10.0PIK3CA, KRAS, TSG101
17ovarian cancer10.0KRAS, BRCA1
18ovarian cancer, somatic10.0IGH, AKT1, PIK3CA
19colorectal cancer, somatic10.0IGH, AKT1, PIK3CA
20bilateral breast cancer10.0ATM, BRCA1
21mental retardation10.0AKT1, ATM
22stomach cancer10.0PIK3CA, AKT1, KRAS
23pancreatic cancer10.0AKT1, ATM, KRAS
24acute lymphoblastic leukemia, childhood10.0ATM, IGH, KRAS
25glioblastoma multiforme10.0ATM, AKT1, PIK3CA
26li-fraumeni syndrome10.0ATM, BRCA1
27breast cancer, invasive ductal10.0ATM, BRCA1
28lung cancer10.0KRAS, ATM, PIK3CA
29astrocytoma10.0AKT1, PIK3CA, BRCA1
30bladder carcinoma10.0KRAS, PIK3CA, BRCA1
31ataxia telangiectasia10.0BRCA1, PIK3CA, ATM
32adenoma10.0KRAS, ATM, BRCA1
33nijmegen breakage syndrome10.0ATM, BRCA1
34acute leukemia10.0KRAS, IGH, ATM, PIK3CA
35hypertrophy of breast10.0BRCA1, PIK3CA, AKT1
36autosomal dominant disease10.0AKT1, BRCA1
37hodgkin's lymphoma10.0BRCA1, ATM, IGH
38endometrial carcinoma10.0KRAS, AKT1, PIK3CA, BRCA1
39t-cell leukemia10.0TSG101, IGH, ATM, AKT1
40adenocarcinoma10.0KRAS, AKT1, PIK3CA, BRCA1
41burkitt's lymphoma10.0PIK3CA, AKT1, ATM, IGH, KRAS
42retinoblastoma10.0KRAS, AKT1, RB1CC1, PIK3CA, BRCA1
43colon cancer10.0BRCA1, PIK3CA, AKT1, ATM, KRAS
44colorectal cancer9.9BRCA1, PIK3CA, AKT1, ATM, KRAS
45breast cancer9.9BRCA1, PIK3CA, AKT1, ATM, KRAS, TSG101
46prostate cancer9.9BRCA1, PIK3CA, AKT1, ATM, KRAS, TSG101
47leukemia9.9BRCA1, PIK3CA, AKT1, ATM, IGH, KRAS

Graphical network of the top 20 diseases related to Breast Cancer, Somatic:



Diseases related to breast cancer, somatic

Clinical Features for Breast Cancer, Somatic

Sources:
47OMIM
See all sources

Clinical features from OMIM:

114480

Drugs & Therapeutics for Breast Cancer, Somatic

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Breast Cancer, Somatic

Drug clinical trials:

Search ClinicalTrials for Breast Cancer, Somatic

Search NIH Clinical Center for Breast Cancer, Somatic

Search CenterWatch for Breast Cancer, Somatic

Genetic Tests for Breast Cancer, Somatic

Anatomical Context for Breast Cancer, Somatic

Sources:
33MalaCards
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MalaCards organs/tissues related to Breast Cancer, Somatic:

33
Breast, Prostate

Animal Models for Breast Cancer, Somatic or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Breast Cancer, Somatic

Sources:
51PubMed
See all sources

Articles related to Breast Cancer, Somatic:

(show all 43)
idTitleAuthorsYear
1
Correlation of telomere length shortening with TP53 somatic mutations, polymorphisms and allelic loss in breast tumors and esophageal cancer. (23124483)
2013
2
Somatic mutation profiling and associations with prognosis and trastuzumab benefit in early breast cancer. (23739063)
2013
3
Activating somatic FGFR2 mutations in breast cancer. (23527311)
2013
4
Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers. (22302350)
2012
5
Somatic mutations in the BRCA1 gene in Chinese women with sporadic breast cancer. (22116506)
2012
6
Somatic mutation of a tumor suppressor gene BAP1 is rare in breast, prostate, gastric and colorectal cancers. (22958294)
2012
7
Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer. (22976806)
2012
8
Somatic mutations of the mixed-lineage leukemia 3 (MLL3) gene in primary breast cancers. (21116761)
2011
9
Number of somatic mutations in the mitochondrial D-loop region indicates poor prognosis in breast cancer, independent of TP53 mutation. (20682393)
2010
10
A controlled study of mental distress and somatic complaints after risk-reducing salpingo-oophorectomy in women at risk for hereditary breast ovarian cancer. (19178933)
2009
11
Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer. (19188684)
2009
12
PIK3CA somatic mutations in breast cancer: Mechanistic insights from Langevin dynamics simulations. (18951408)
2009
13
Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer. (18541649)
2008
14
Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD). (18186519)
2008
15
ATBF1 and NQO1 as candidate targets for allelic loss at chromosome arm 16q in breast cancer: absence of somatic ATBF1 mutations and no role for the C609T NQO1 polymorphism. (18416817)
2008
16
Somatic mutation analysis of MYH11 in breast and prostate cancer. (18796164)
2008
17
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. (17626182)
2007
18
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. (17687336)
2007
19
Somatic mutations of mitochondrial genome in early stage breast cancer. (17514652)
2007
20
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer. (16489069)
2006
21
Somatic mutation and gain of copy number of PIK3CA in human breast cancer. (16168105)
2005
22
Two somatic biallelic lesions within and near SMAD4 in a human breast cancer cell line. (15645498)
2005
23
High frequency of somatic missense mutation of BRCA2 in female breast cancer from Taiwan. (15766593)
2005
24
A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation. (15709182)
2005
25
Two novel somatic mutations in the human interleukin 6 promoter region in a patient with sporadic breast cancer. (14675392)
2003
26
Somatic mutations in the BRCA2 gene and high frequency of allelic loss of BRCA2 in sporadic male breast cancer. (11948477)
2002
27
Somatic gene alteration of AIB1 gene in patients with breast cancer. (11456268)
2001
28
A somatic mutation in the 5'UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency. (11494157)
2001
29
Resistance to CD95-mediated apoptosis in breast cancer is not due to somatic mutation of the CD95 gene. (11291062)
2001
30
Two identical triplet sisters carrying a germline BRCA1 gene mutation acquire very similar breast cancer somatic mutations at multiple other sites throughout the genome. (10862044)
2000
31
Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus. (10944226)
2000
32
Somatic mutations of the APC gene in primary breast cancers. (10854222)
2000
33
Loss of heterozygosity at 11q23.1 and survival in breast cancer: results of a large European study. Breast Cancer Somatic Genetics Consortium. (10379867)
1999
34
Somatic genetic alterations in BRCA2-associated and sporadic male breast cancer. (9892109)
1999
35
Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis. (10471047)
1999
36
Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer. (10467410)
1999
37
Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability. (10503872)
1999
38
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. (9537235)
1998
39
Identification of a possible somatic BRCA1 mutation affecting translation efficiency in an early-onset sporadic breast cancer patient. (9665150)
1998
40
Human breast cancer progression can be regulated by dominant trans-acting factors in somatic cell hybridization studies. (8758927)
1996
41
Somatic genetic changes in human breast cancer. (7819270)
1994
42
A somatic cell hybrid map of the long arm of human chromosome 17, containing the familial breast cancer locus (BRCA1). (8460635)
1993
43
A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers. (8252040)
1993

Genetic Variations for Breast Cancer, Somatic

Expression for genes affiliated with Breast Cancer, Somatic

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Breast Cancer, Somatic

Search GEO for disease gene expression data for Breast Cancer, Somatic.

Pathways for genes affiliated with Breast Cancer, Somatic

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 53R&D Systems, 60Tocris Bioscience, 50PharmGKB, 52QIAGEN, 56SinoBiological
See all sources

Pathways related to Breast Cancer, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PIK3CA, KRAS
29.7PIK3CA, KRAS
39.6PIK3CA, AKT1
49.6AKT1, PIK3CA
59.6PIK3CA, AKT1
69.6AKT1, PIK3CA
79.6AKT1, PIK3CA
89.6AKT1, PIK3CA
99.6PIK3CA, AKT1
109.6PIK3CA, AKT1
119.6PIK3CA, AKT1
12
G-protein signaling Cross-talk between Ras-family GTPases
Hide members
9.6AKT1, PIK3CA
139.6PIK3CA, AKT1
14
Hide members
9.2PIK3CA, KRAS, AKT1
15
Development Prolactin receptor signaling
Hide members
9.2AKT1, PIK3CA, KRAS
16
Hide members
9.2PIK3CA, AKT1, KRAS
179.2AKT1, PIK3CA, KRAS
189.2AKT1, KRAS, PIK3CA
19
Hide members
9.2AKT1, KRAS, PIK3CA
20
Hide members
9.2AKT1, KRAS, PIK3CA
21
Hide members
9.2PIK3CA, KRAS, AKT1
22
Hide members
9.2PIK3CA, AKT1, KRAS
23
Hide members
9.2PIK3CA, AKT1, KRAS
24
Hide members
9.2PIK3CA, KRAS, AKT1
259.2KRAS, PIK3CA, AKT1
26
Hide members
9.2KRAS, PIK3CA, AKT1
27
Development Endothelin-1/EDNRA signaling
Hide members
9.2KRAS, PIK3CA, AKT1
28
Hide members
9.2KRAS, AKT1, PIK3CA
29
Hide members
9.2KRAS, AKT1, PIK3CA
30
Immune response NFAT in immune response
Hide members
9.1AKT1, PIK3CA, IGH
31
Signal transduction IP3 signaling
Hide members
9.1AKT1, IGH, PIK3CA
329.0BRCA1, ATM
33
Hide members
9.0BRCA1, ATM
34
Hide members
9.0ATM, BRCA1
359.0BRCA1, ATM
36
Hide members
9.0AKT1, ATM, PIK3CA
37
Immune response IFN gamma signaling pathway
Hide members
8.8AKT1, PIK3CA, BRCA1
388.7KRAS, AKT1, TSG101, PIK3CA
39
Hide members
8.7AKT1, KRAS, PIK3CA, IGH
408.6KRAS, ATM, PIK3CA, AKT1
41
Hide members
8.6ATM, AKT1, KRAS, PIK3CA
42
Hide members
8.6BRCA1, AKT1, ATM
43
Hide members
8.4BRCA1, AKT1, KRAS, PIK3CA
448.4PIK3CA, AKT1, BRCA1, KRAS
45
Hide members
8.3AKT1, RB1CC1, BRCA1, TSG101
468.2KRAS, BRCA1, ATM, PIK3CA
478.2AKT1, BRCA1, ATM, KRAS
48
Hide members
8.2BRCA1, PIK3CA, AKT1, ATM
49
Hide members
7.8AKT1, KRAS, ATM, PIK3CA, BRCA1
507.4KRAS, ATM, AKT1, RB1CC1, PIK3CA, BRCA1

Compounds for genes affiliated with Breast Cancer, Somatic

Sources:
60Tocris Bioscience, 45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Breast Cancer, Somatic according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1fpa 124609.9AKT1, IGH
210-debc hydrochloride609.9AKT1, IGH
3api-1609.9AKT1, IGH
4api-2609.9AKT1, IGH
5sc 79609.9AKT1, IGH
6ptdins(3)p459.9AKT1, PIK3CA
7farnesyl diphosphate45 29 1111.8AKT1, KRAS
8crcs459.8KRAS, PIK3CA
9gefitinib45 50 1111.6PIK3CA, AKT1, KRAS
10erlotinib45 50 1111.6KRAS, PIK3CA
11bpde459.3ATM, BRCA1
12ceramide459.3ATM, AKT1, PIK3CA
13indole-3-carbinol459.2BRCA1, AKT1
14aphidicolin459.2BRCA1, ATM
155fluorouracil459.1BRCA1, PIK3CA, KRAS
16topotecan45 1110.0ATM, BRCA1
17agar459.0AKT1, PIK3CA, BRCA1
18vincristine45 50 1111.0BRCA1, AKT1, TSG101
19adriamycin459.0TSG101, AKT1, BRCA1
20rapamycin459.0KRAS, ATM, AKT1, PIK3CA
21ly294002459.0PIK3CA, AKT1, ATM, KRAS
22wortmannin459.0KRAS, ATM, AKT1, PIK3CA
23phosphoinositide459.0KRAS, ATM, AKT1, PIK3CA
24tamoxifen45 50 29 1111.9AKT1, PIK3CA, BRCA1
25paclitaxel45 50 1110.8BRCA1, PIK3CA, AKT1, KRAS
26h2o2458.7BRCA1, PIK3CA, AKT1, KRAS
27vegf458.6KRAS, AKT1, PIK3CA, BRCA1
28etoposide45 50 60 1111.6BRCA1, PIK3CA, AKT1, ATM
29testosterone45 60 11 2411.6BRCA1, PIK3CA, AKT1, TSG101
30polyacrylamide458.6KRAS, IGH, ATM, BRCA1
31paraffin458.6BRCA1, AKT1, ATM, KRAS
32doxorubicin45 50 1110.5ATM, AKT1, PIK3CA, BRCA1
33genistein45 29 60 2 11 2413.5ATM, AKT1, PIK3CA, BRCA1
34cisplatin45 50 60 1111.2BRCA1, PIK3CA, AKT1, ATM, KRAS
35phosphatidylinositol458.2BRCA1, PIK3CA, AKT1, ATM, KRAS
36retinoic acid45 249.1KRAS, AKT1, PIK3CA, BRCA1
37lipid458.1BRCA1, PIK3CA, AKT1, ATM, KRAS
38serine458.0BRCA1, PIK3CA, AKT1, ATM, KRAS
39estrogen457.7TSG101, KRAS, ATM, AKT1, PIK3CA, BRCA1
40tyrosine457.6BRCA1, PIK3CA, AKT1, ATM, KRAS, TSG101

GO Terms for genes affiliated with Breast Cancer, Somatic

Sources:
16Gene Ontology
See all sources

Biological processes related to Breast Cancer, Somatic according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1striated muscle cell differentiationGO:0511469.9KRAS, AKT1
2positive regulation of nitric-oxide synthase activityGO:0510009.9KRAS, AKT1
3protein kinase B signaling cascadeGO:0434919.7AKT1, PIK3CA
4positive regulation of peptidyl-serine phosphorylationGO:0331389.6AKT1, PIK3CA
5positive regulation of protein phosphorylationGO:0019349.6KRAS, AKT1, RB1CC1
6insulin receptor signaling pathwayGO:0082869.5PIK3CA, AKT1, KRAS
7fibroblast growth factor receptor signaling pathwayGO:0085439.5KRAS, AKT1, PIK3CA
8Fc-epsilon receptor signaling pathwayGO:0380959.4KRAS, AKT1, PIK3CA
9epidermal growth factor receptor signaling pathwayGO:0071739.4PIK3CA, AKT1, KRAS
10neurotrophin TRK receptor signaling pathwayGO:0480119.2PIK3CA, AKT1, KRAS
11intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.2ATM, BRCA1
12G2 DNA damage checkpointGO:0315729.1ATM, BRCA1
13response to ionizing radiationGO:0102128.9ATM, BRCA1
14double-strand break repair via homologous recombinationGO:0007248.7ATM, BRCA1

Molecular functions related to Breast Cancer, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:0163019.5AKT1, PIK3CA
21-phosphatidylinositol-3-kinase activityGO:0163039.4ATM, PIK3CA
3protein serine/threonine kinase activityGO:0046749.0ATM, AKT1, PIK3CA
4protein bindingGO:0055156.6BRCA1, PIK3CA, RB1CC1, AKT1, ATM, KRAS

Products for genes affiliated with Breast Cancer, Somatic

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Breast Cancer, Somatic

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet