MCID: BRS049
MIFTS: 55

Breast Carcinoma in Situ malady

Cancer diseases category

Summaries for Breast Carcinoma in Situ

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MalaCards: Breast Carcinoma in Situ, also known as non-infiltrating carcinoma of breast, is related to breast cancer and ductal carcinoma in situ. An important gene associated with Breast Carcinoma in Situ is LIF (leukemia inhibitory factor), and among its related pathways are CREB Pathway and Malaria. The compounds cycloheximide and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and testes, and related mouse phenotypes are limbs/digits/tail and adipose tissue.

Aliases & Classifications for Breast Carcinoma in Situ

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8Disease Ontology, 56SNOMED-CT, 60UMLS, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

breast carcinoma in situ 8
non-infiltrating carcinoma of breast 8
carcinoma in situ of breast 8


External Ids:

Disease Ontology8 DOID:8791
NCIt39 C3641
ICD9CM27 233.0
ICD1025 D05

Related Diseases for Breast Carcinoma in Situ

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Breast Cancer family:

Inflammatory Breast Carcinoma Breast Benign Neoplasm
breast carcinoma in situ Familial Breast Cancer
Chek2-Related Susceptibility to Breast Cancer Bard1-Related Susceptibility to Breast Cancer
Brip1-Related Breast Cancer Breast Cancer, Type 3
Breast Cancer, Early-Onset

Diseases related to Breast Carcinoma in Situ via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.7BRCA1, BRCA2
2ductal carcinoma in situ30.7BRCA1, BRCA2, CDH1, ERBB2, TP53
3ovarian cancer30.2BRCA1, BRCA2, MET, LIF, VEGFC, CDH1
4in situ carcinoma11.0
5breast apocrine carcinoma10.2
6poland syndrome10.2
7breast apocrine carcinoma in situ10.2
8female breast carcinoma10.1
9breast disease10.1
10pituitary adenoma10.0LIF
11malaria10.0LIF
12angiosarcoma10.0VEGFC
13dermatitis10.0LIF
14cervical intraepithelial neoplasia10.0VEGFC
15ischemia10.0VEGFC
16von hippel-lindau disease10.0MET
17chordoma10.0KRT19
18dilated cardiomyopathy10.0IL6ST
19nephritis10.0LIF
20breast-ovarian cancer, familial, 210.0BRCA2
21acute leukemia10.0IL6ST
22multiple endocrine neoplasia10.0BRCA2
23colon adenocarcinoma10.0CDH1
24gallbladder cancer10.0TP53
25neuroblastoma10.0TP53
26gastritis10.0TP53
27infertility10.0IL6ST, LIF
28prolactinoma10.0IL6ST, LIF
29proliferative diabetic retinopathy10.0MET
30ulcerative colitis10.0TP53
31teratoma10.0LIF
32pheochromocytoma10.0LIF, IL6ST
33uterine carcinosarcoma10.0ERBB2
34hepatoblastoma10.0LIF, MET
35leiomyosarcoma10.0TP53
36pemphigus vulgaris10.0CDH1
37werner syndrome10.0BRCA1
38gastrointestinal system disease10.0CDH1
39papilloma10.0TP53
40wilms tumor10.0VEGFC, BRCA2
41chondrosarcoma10.0KRT19, MET
42cystadenoma10.0BRCA1, VEGFC
43hereditary diffuse gastric cancer10.0CDH1
44malignant mesothelioma10.0CDH1, MET
45bilateral breast cancer10.0BRCA1, BRCA2
46neutropenia10.0ERBB2, LIF
47aplastic anemia10.0BRCA2, BRCA1
48laryngeal benign neoplasm10.0TP53, VEGFC
49liver cirrhosis10.0TGFB1
50biliary tract neoplasm10.0MET, ERBB2

Graphical network of the top 20 diseases related to Breast Carcinoma in Situ:



Diseases related to breast carcinoma in situ

Clinical Features for Breast Carcinoma in Situ

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Drugs & Therapeutics for Breast Carcinoma in Situ

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Breast Carcinoma in Situ

Drug clinical trials:

Search ClinicalTrials for Breast Carcinoma in Situ

Search NIH Clinical Center for Breast Carcinoma in Situ

Search CenterWatch for Breast Carcinoma in Situ

Genetic Tests for Breast Carcinoma in Situ

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Anatomical Context for Breast Carcinoma in Situ

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32MalaCards
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MalaCards organs/tissues related to Breast Carcinoma in Situ:

32
Breast, Lymph node, Testes, Smooth muscle, Cervix

Animal Models for Breast Carcinoma in Situ or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Breast Carcinoma in Situ:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.2BRCA2
2MP:000537510.1LIF
3MP:00053919.9LIF
4MP:00053809.6KRT19, ERBB2
5MP:00053699.5MET, TP53, TGFB1
6MP:00053769.4BRCA1, BRCA2, LIF, IL6ST
7MP:00036318.4LIF, IL6ST, KRT19, ERBB2, TGFB1
8MP:00053888.2BRCA1, MET, LIF, IL6, ERBB2, TP53
9MP:00053708.2MET, LIF, IL6, IL6ST, TP53, TGFB1
10MP:00053908.1BRCA1, BRCA2, LIF, IL6, IL6ST, KRT19
11MP:00053977.9BRCA2, LIF, IL6, IL6ST, TP53, TGFB1
12MP:00020067.8TGFB1, MET, CDH1, IL6, KRT19, ERBB2
13MP:00053897.6BRCA1, BRCA2, LIF, CDH1, KRT19, ERBB2
14MP:00053797.4BRCA1, BRCA2, LIF, IL6, IL6ST, KRT19
15MP:00028737.4BRCA1, BRCA2, MET, CDH1, IL6ST, KRT19
16MP:00053867.4BRCA1, BRCA2, OSM, MET, LIF, IL6
17MP:00053876.8BRCA1, BRCA2, MET, LIF, VEGFC, CDH1
18MP:00053856.5VEGFC, LIF, MET, BRCA1, CDH1, IL6
19MP:00053816.5LIF, MET, BRCA2, BRCA1, CDH1, IL6
20MP:00107716.5BRCA1, BRCA2, OSM, LIF, CDH1, IL6
21MP:00053786.4BRCA1, BRCA2, MET, LIF, CDH1, IL6
22MP:00053845.9CDH1, LIF, MET, BRCA2, BRCA1, IL6
23MP:00107685.7VEGFC, LIF, MET, BRCA2, BRCA1, CDH1

Publications for Breast Carcinoma in Situ

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50PubMed
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Articles related to Breast Carcinoma in Situ:

(show top 50)    (show all 608)
idTitleAuthorsYear
1
Ductal carcinoma in situ of the breast: can biomarkers improve current management? (24262106)
2014
2
Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer. (23208501)
2013
3
Role of HGF in epithelial-stromal cell interactions during progression from benign breast disease to ductal carcinoma in situ. (24025166)
2013
4
Implications on glycobiological aspects of tumor hypoxia in breast ductal carcinoma in situ. (23381603)
2013
5
Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: relationships with markers of tumor hypoxia and microvascularity. (23036368)
2013
6
Comparison of two breast carcinomas: ductal carcinoma in situ and lobular carcinoma in situ. (24147320)
2013
7
Ductal carcinoma inA situ arising in tubular adenoma of the breast. (22700460)
2012
8
The evaluation of the immunoexpression of Her2A^neu oncoprotein in ductal carcinoma in situ in association with invasive ductal carcinoma of the breast. (23188444)
2012
9
Differentially expressed genes regulating the progression of ductal carcinoma in situ to invasive breast cancer. (22751464)
2012
10
Hematogenous and lymphatic tumor cell dissemination may be detected in patients diagnosed with ductal carcinoma in situ of the breast. (21455667)
2012
11
Ductal carcinoma in situ at core-needle biopsy: meta-analysis of underestimation and predictors of invasive breast cancer. (21493791)
2011
12
Molecular differences between ductal carcinoma in situ and adjacent invasive breast carcinoma: a multiplex ligation-dependent probe amplification study. (21547576)
2011
13
Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer. (21710692)
2011
14
Grading ductal carcinoma in situ of the breast using an automated proliferation index. (21844569)
2011
15
Ipsilateral breast tumor recurrence after breast-conserving surgery for ductal carcinoma in situ. (21522008)
2011
16
A Comparative Analysis of Biomarker Expression and Molecular Subtypes of Pure Ductal Carcinoma In Situ and Invasive Breast Carcinoma by Image Analysis: Relationship of the Subtypes with Histologic Grade, Ki67, p53 Overexpression, and DNA Ploidy. (22295212)
2011
17
A rare case of male breast ductal carcinoma in-situ associated with prolactinoma. (22679041)
2011
18
Neuroendocrine ductal carcinoma in situ of the breast: cytological features in 32 cases. (20236292)
2011
19
Mammographycally occult high grade ductal carcinoma in situ (DCIS) as second primary breast cancer, detected with MRI: a case report. (22933920)
2010
20
Gene amplification in ductal carcinoma in situ of the breast. (20033484)
2010
21
Alcohol consumption and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women. (20647412)
2010
22
PIK3CA mutations in in situ and invasive breast carcinomas. (20551053)
2010
23
Immunohistochemical expression of E-cadherin in sclerosing adenosis, ductal carcinoma in situ and invasive ductal carcinoma of the breast. (19790246)
2010
24
Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer. (20105298)
2010
25
Costimulatory molecule OX40/OX40L expression in ductal carcinoma in situ and invasive ductal carcinoma of breast: an immunohistochemistry-based pilot study. (20634005)
2010
26
Ductal carcinoma in situ of the breast treated with accelerated partial breast irradiation using balloon-based brachytherapy. (20443148)
2010
27
Ductal carcinoma in situ of the breast. Long-term follow-up of health-related quality of life, emotional reactions and body image. (20598492)
2010
28
Comparison of chromogenic in situ hybridisation with fluorescence in situ hybridisation and immunohistochemistry for the assessment of her-2/neu oncogene in archival material of breast carcinoma. (18636112)
2008
29
Analysis of HER2 by chromogenic in situ hybridization and immunohistochemistry in lymph node-negative breast carcinoma: Prognostic relevance. (17056098)
2007
30
EGFR gene copy number heterogeneity in fine-needle aspiration cytology from breast carcinomas determined by chromogenic in situ hybridization. (16138375)
2005
31
Loss of heterozygosity at BRCA2 in a ductal carcinoma in situ and three invasive breast carcinomas in a family with a germline BRCA2 mutation. (15528970)
2004
32
Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. (15564794)
2004
33
Evaluation of MUC1 splice variants as prognostic markers in patients with ductal carcinoma in situ of the breast. (14534730)
2003
34
A comparison of five immunohistochemical biomarkers and HER-2/neu gene amplification by fluorescence in situ hybridization in white and Korean patients with early-onset breast carcinoma. (14534873)
2003
35
Lifetime recreational exercise activity and risk of breast carcinoma in situ. (14601085)
2003
36
Collagenous spherulosis of the breast in association with in situ carcinoma. (12540997)
2002
37
p63 Staining of myoepithelial cells in breast fine needle aspirates: a study of its role in differentiating in situ from invasive ductal carcinomas of the breast. (12461063)
2002
38
Effect of fixation period on HER2/neu gene amplification detected by fluorescence in situ hybridization in invasive breast carcinoma. (12486093)
2002
39
p53 missense mutations in microdissected high-grade ductal carcinoma in situ of the breast. (11333292)
2001
40
Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma. (11685554)
2001
41
Fine-needle aspiration cytology of the breast: Invasive vs. in situ carcinoma. (11466818)
2001
42
Microvessel density, proliferating activity, p53 and bcl-2 expression in in situ ductal carcinoma of the breast. (10652623)
1999
43
p53 protein expression, cell proliferation and steroid hormone receptors in ductal and lobular in situ carcinomas of the breast. (9071897)
1997
44
Prognostic significance of in situ carcinoma associated with invasive breast carcinoma: a natural experiment in cancer immunology? (9129007)
1997
45
c-erbB-3 protein expression in ductal carcinoma in situ of the breast. (9470844)
1997
46
Analysis of loss of heterozygosity on chromosome 11q13 in atypical ductal hyperplasia and in situ carcinoma of the breast. (9006344)
1997
47
High levels of allele loss at the FHIT and ATM genes in non-comedo ductal carcinoma in situ and grade I tubular invasive breast cancers. (8968105)
1996
48
TP53 alterations in atypical ductal hyperplasia and ductal carcinoma in situ of the breast. (8944328)
1996
49
Oestrogen receptor expression in ductal carcinoma in situ of the breast: relationship to flow cytometric analysis of DNA and expression of the c-erbB-2 oncoprotein. (8100443)
1993
50
An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part II: Epitheliosis and ductal carcinoma in situ. (1384227)
1992

Genetic Variations for Breast Carcinoma in Situ

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Expression for genes affiliated with Breast Carcinoma in Situ

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Carcinoma in Situ

Search GEO for disease gene expression data for Breast Carcinoma in Situ.

Pathways for genes affiliated with Breast Carcinoma in Situ

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 59Tocris Bioscience, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 55SinoBiological
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Pathways related to Breast Carcinoma in Situ according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2VEGFC
210.0SDC1
310.0SDC1
4
Hide members
10.0VEGFC, MET
5
Hide members
9.8MET, IL6
69.7TP53, BRCA1
79.7TGFB1, IL6
8
Hide members
9.7TP53, ERBB2
9
Hide members
9.6VEGFC, ERBB2, MET
10
Hide members
9.6SDC1, TGFB1
11
Hide members
9.6TGFB1, SDC1
129.6LIF, VEGFC, IL6
13
Hide members
9.6VEGFC, CDH1, ERBB2
149.5MET, CDH1, ERBB2
159.4TP53, BRCA2, BRCA1
16
Hide members
9.4BRCA2, BRCA1, TP53
17
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.4BRCA2, BRCA1, TP53
189.4ERBB2, MET, TP53
199.4TP53, ERBB2, CDH1
209.3TGFB1, IL6ST, LIF
219.3MET, TGFB1, SDC1
229.2TGFB1, TP53, IL6
239.2IL6, IL6ST, ERBB2
24
Hide members
9.2TGFB1, VEGFC, MET, IL6
25
Cytokine production by Th17 cells in CF (Mouse model)
9.2IL6, IL6ST, TGFB1
26
Hide members
9.2IL6, TGFB1, IL6ST
279.2TGFB1, IL6, IL6ST
289.2CDH1, TP53, VEGFC, BRCA1
299.1MET, BRCA1, TP53, ERBB2
309.1BRCA1, TP53, CDH1, BRCA2
319.1LIF, OSM, IL6ST
32
Hide members
9.1CDH1, ERBB2, TP53, MET
33
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9.0TGFB1, BRCA2, ERBB2, TP53
34
Translation Insulin regulation of translation
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9.0ERBB2, TGFB1, IL6ST, MET
35
Hide members
9.0IL6ST, ERBB2, LIF, IL6
36
Immune response Oncostatin M signaling via JAK-Stat in human cells
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8.9IL6ST, IL6, OSM
37
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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8.9TP53, IL6ST, OSM
38
Transcription Androgen Receptor nuclear signaling
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8.8IL6ST, ERBB2, TGFB1, IL6
398.7TP53, ERBB2, BRCA2, BRCA1, TGFB1
408.7TP53, IL6ST, IL6, TGFB1
418.5ERBB2, SDC1, MET, TP53, TGFB1
42
Hide members
8.4MET, LIF, VEGFC, ERBB2, TGFB1, OSM
438.3LIF, TGFB1, IL6ST, IL6, OSM
448.3TP53, ERBB2, IL6, CDH1, BRCA2, TGFB1
458.2MET, BRCA1, OSM, TP53, IL6, VEGFC
46
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8.1TP53, TGFB1, ERBB2, IL6, VEGFC, BRCA2
47
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7.6TGFB1, LIF, VEGFC, IL6, IL6ST, ERBB2
48
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7.5ERBB2, OSM, MET, LIF, VEGFC, IL6
49
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7.4OSM, IL6ST, ERBB2, LIF, IL6, VEGFC
50
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6.9TGFB1, BRCA1, OSM, MET, TP53, ERBB2

Compounds for genes affiliated with Breast Carcinoma in Situ

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Breast Carcinoma in Situ according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.3BRCA1, BRCA2
2tamoxifen44 49 28 1112.8TGFB1, ERBB2, CDH1
3pge2449.7CDH1, TGFB1, MET, VEGFC
4estradiol44 11 2411.6VEGFC, OSM, BRCA2
5il 11449.5IL6, LIF, OSM
6indole-3-carbinol449.5BRCA2, CDH1, BRCA1, TP53
7methylcellulose449.4IL6, LIF, TGFB1, CDH1
8heparin44 28 11 2412.3ERBB2, CDH1, LIF, BRCA1
94-hydroxytamoxifen449.3TGFB1, BRCA2, ERBB2, BRCA1
10vitamin d449.3IL6ST, IL6, ERBB2, MET
11depsipeptide449.1TP53, OSM, CDH1, LIF
12bleomycin44 1110.1BRCA1, BRCA2, TP53, TGFB1
13bortezomib44 1110.0BRCA1, TP53, ERBB2, IL6
145fluorouracil449.0TP53, ERBB2, CDH1, BRCA1, LIF
15matrigel449.0LIF, BRCA2, CDH1, KRT19, MET
16ifn-alpha448.9IL6, LIF, OSM, IL6ST
17pdtc448.9MET, TGFB1, TP53, IL6
18carboplatin44 49 1110.9TP53, ERBB2, LIF, BRCA1
19tgf beta1448.8OSM, TGFB1, IL6, CDH1, LIF
20herbimycin a44 599.8CDH1, ERBB2, MET, IL6, OSM
21methotrexate44 49 1110.8CDH1, BRCA2, BRCA1, TGFB1, IL6, ERBB2
22curcumin448.8CDH1, TGFB1, TP53, ERBB2, IL6
23docetaxel44 49 59 1111.8BRCA2, TGFB1, BRCA1, TP53, ERBB2, CDH1
24etoposide44 49 59 1111.8TGFB1, CDH1, BRCA2, BRCA1, TP53, ERBB2
25doxorubicin44 49 1110.8BRCA1, MET, CDH1, ERBB2, TGFB1, TP53
26p002448.5BRCA1, MET, CDH1, KRT19, BRCA2, ERBB2
27proline448.5TP53, CDH1, BRCA2, BRCA1, IL6ST, MET
28phosphotyrosine448.5OSM, MET, CDH1, IL6ST, ERBB2, BRCA1
29ly294002448.5CDH1, TP53, IL6, ERBB2, TGFB1, VEGFC
30pd 98,059448.4TGFB1, IL6, MET, OSM, CDH1, VEGFC
31ribonucleic acid448.4TGFB1, IL6ST, KRT19, VEGFC, MET, LIF
32agar448.3OSM, BRCA1, MET, LIF, CDH1, IL6ST
33hyaluronic acid44 249.2CDH1, OSM, IL6, KRT19, TGFB1
34oligonucleotide448.2BRCA1, MET, IL6ST, TGFB1, TP53, VEGFC
35steroid448.2OSM, LIF, BRCA1, BRCA2, KRT19, ERBB2
36lactate448.1IL6, LIF, CDH1, TGFB1, ERBB2, KRT19
37dexamethasone44 49 28 1111.1IL6ST, IL6, LIF, OSM, CDH1, TGFB1
38paclitaxel44 49 119.8TP53, LIF, BRCA1, BRCA2, ERBB2, TGFB1
39phosphatidylinositol447.7VEGFC, IL6ST, BRCA1, OSM, MET, ERBB2
40alanine447.7TGFB1, ERBB2, BRCA1, IL6ST, IL6, CDH1
41testosterone44 59 11 2410.7BRCA2, IL6, LIF, VEGFC, CDH1, ERBB2
42genistein44 28 59 2 11 2412.6ERBB2, IL6ST, IL6, CDH1, LIF, MET
43cisplatin44 49 59 1110.5BRCA1, BRCA2, MET, CDH1, KRT19, ERBB2
44serine447.3BRCA1, TGFB1, OSM, LIF, CDH1, IL6ST
45paraffin447.3KRT19, ERBB2, VEGFC, TGFB1, CDH1, TP53
46progesterone44 59 28 11 2411.1BRCA1, BRCA2, MET, LIF, ERBB2, IL6ST
47thymidine44 247.9BRCA1, TGFB1, TP53, KRT19, BRCA2, VEGFC
48tyrosine446.8OSM, MET, VEGFC, LIF, CDH1, IL6
49retinoic acid44 247.0KRT19, TGFB1, TP53, IL6ST, IL6, CDH1
50vegf446.0TGFB1, TP53, KRT19, IL6ST, IL6, CDH1

GO Terms for genes affiliated with Breast Carcinoma in Situ

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Sources:
16Gene Ontology
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Cellular components related to Breast Carcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor complexGO:0058969.7IL6ST, IL6
2oncostatin-M receptor complexGO:0059009.4IL6ST, OSM
3focal adhesionGO:0059259.1SDC1, CDH1, BRCA1
4protein complexGO:0432348.8BRCA1, BRCA2, TP53, SDC1
5extracellular regionGO:0055768.1VEGFC, IL6, IL6ST, SDC1, TGFB1, MET
6extracellular spaceGO:0056158.1OSM, LIF, VEGFC, IL6, IL6ST, TGFB1

Biological processes related to Breast Carcinoma in Situ according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1cellular response to indole-3-methanolGO:07168110.2CDH1, BRCA1
2leukemia inhibitory factor signaling pathwayGO:04886110.0LIF, IL6ST
3tyrosine phosphorylation of Stat3 proteinGO:0425039.9LIF, OSM
4positive regulation of astrocyte differentiationGO:0487119.9LIF, IL6ST
5positive regulation of tyrosine phosphorylation of Stat1 proteinGO:0425119.9LIF, IL6ST
6positive regulation of histone deacetylationGO:0310659.9TP53, TGFB1
7negative regulation of neuroblast proliferationGO:0074069.9TP53, TGFB1
8negative regulation of meiosisGO:0458359.9OSM, LIF
9negative regulation of cell-cell adhesionGO:0224089.8TGFB1, CDH1
10positive regulation of histone acetylationGO:0350669.8TGFB1, BRCA1
11interleukin-6-mediated signaling pathwayGO:0701029.8IL6, IL6ST
12DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.8TP53, BRCA2, BRCA1
13positive regulation of blood vessel endothelial cell migrationGO:0435369.7VEGFC, TGFB1
14double-strand break repairGO:0063029.7BRCA1, BRCA2, TP53
15positive regulation of cell cycle arrestGO:0711589.7BRCA1, TP53, TGFB1
16positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.7IL6ST, IL6, LIF
17negative regulation of hormone secretionGO:0468889.6IL6, LIF, OSM
18positive regulation vascular endothelial growth factor productionGO:0105759.6TGFB1, IL6ST
19positive regulation of cell divisionGO:0517819.6TGFB1, VEGFC, OSM
20positive regulation of MAPK cascadeGO:0434109.5IL6, LIF, OSM
21positive regulation of epithelial cell proliferationGO:0506799.5VEGFC, IL6, ERBB2, TGFB1
22response to X-rayGO:0101659.4TP53, BRCA2
23response to drugGO:0424939.4VEGFC, CDH1, IL6, TGFB1
24positive regulation of acute inflammatory responseGO:0026759.3OSM, IL6, IL6ST
25positive regulation of peptidyl-serine phosphorylationGO:0331389.2TGFB1, IL6, LIF, OSM
26positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1OSM, LIF, IL6, TP53
27cell proliferationGO:0082838.9OSM, MET, ERBB2, TP53
28negative regulation of cell proliferationGO:0082858.7OSM, LIF, IL6, TP53, TGFB1
29positive regulation of transcription, DNA-dependentGO:0458938.7BRCA1, BRCA2, CDH1, IL6, TP53, TGFB1
30modulation by virus of host morphology or physiologyGO:0190488.4TGFB1, TP53, KRT19, IL6ST
31positive regulation of cell proliferationGO:0082848.4OSM, LIF, VEGFC, IL6, IL6ST, TGFB1
32positive regulation of transcription from RNA polymerase II promoterGO:0459448.2BRCA1, OSM, MET, LIF, IL6, TP53

Molecular functions related to Breast Carcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor bindingGO:0051389.5IL6ST, IL6
2protein phosphatase bindingGO:0199039.2MET, CDH1, ERBB2
3growth factor activityGO:0080838.6TGFB1, IL6, VEGFC, LIF, OSM
4protein bindingGO:0055155.9VEGFC, MET, BRCA2, BRCA1, CDH1, IL6ST

Products for genes affiliated with Breast Carcinoma in Situ

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Breast Carcinoma in Situ

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet