MCID: BRS051
MIFTS: 48

Breast Disease malady

Summaries for Breast Disease

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33MalaCards
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MalaCards: Breast Disease, also known as breast diseases, is related to ductal carcinoma in situ and li-fraumeni syndrome. An important gene associated with Breast Disease is CTSD (cathepsin D), and among its related pathways are Estrogen biosynthesis and Prolactin receptor signaling. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and tumorigenesis.

Aliases & Classifications for Breast Disease

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH
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Aliases & Descriptions:

breast disease 8
breast diseases 61


External Ids:

Disease Ontology8 DOID:3463
NCIt40 C26709
MeSH35 D001941

Related Diseases for Breast Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Breast Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1ductal carcinoma in situ30.2ESR1, ERBB2, PGR
2li-fraumeni syndrome30.2ESR1, ERBB2, SULT1E1, KRT19, PGR, NAT2
3polycystic ovary syndrome30.0PRL, IGF2
4inflammatory breast carcinoma29.7ERBB2, PGR, RHOC, ESR1
5adenoma29.7PSG2, CTSD, TFF1, PRL, PRLR, IGF2
6vascular disease10.1
7lip disease10.1
8breast reconstruction10.0
9uterine disease10.0
10familial breast cancer10.0
11radiation induced cancer10.0
12nutrition disease10.0
13prostatitis10.0KLK3
14gallbladder cancer10.0PSG2
15bilateral breast cancer10.0ESR1, PGR
16leiomyoma10.0ESR1, PGR, IGF2, COMT
17obesity10.0CTSD, COMT
18breast cyst10.0PIP, APOD, AZGP1, KLK3, CTSD
19breast cancer, invasive ductal10.0TFF1, PGR, ERBB2, ESR1, CTSD
20breast fibroadenoma10.0TFF1, PGR, ERBB2, ESR1, CTSD
21thyroid cancer10.0KRT19
22prostatic hypertrophy10.0KLK3
23myeloma10.0PSG2
24syringoma10.0KRT19
25neuroendocrine tumor10.0PRL
26male breast cancer10.0APOD, PGR, ERBB2, ESR1
27tubular adenocarcinoma10.0PGR, ESR1, ERBB2, CTSD
28leukoplakia10.0CYP1A1
29gynecomastia10.0KLK3, APOD, PRL, PGR, ESR1
30hepatitis10.0NAT2, COMT
31parkinson's disease10.0COMT
32lymphangioleiomyomatosis10.0ESR1, PGR
33coronary heart disease10.0COMT
34hidrocystoma10.0PIP
35cervical cancer10.0CYP1A1, PSG2, KRT19, CTSD
36mammary paget's disease10.0PGR, ERBB2, ESR1
37cerebral meningioma10.0PGR, PRLR
38endometrial carcinoma10.0ESR1, KLK3, ERBB2, PGR
39liver cirrhosis10.0NAT2
40factor vii deficiency10.0KLK3, COMT, PSG2, ERBB2, ESR1
41laryngeal carcinoma10.0NAT2, CTSD
42cystic fibrosis10.0NAT2
43hidradenoma10.0PIP
44infertility10.0CYP1A1, ESR1, PRLR, PRL, PIP
45hyperprolactinemia10.0PRL, PRLR
46atherosclerosis10.0COMT, CYP1A1
47oral cancer10.0CYP1A1, CYP1B1, KRT19
48pancreatic cancer10.0KRT19, PSG2, NAT2, ERBB2, TFF1
49pheochromocytoma10.0TFF1, COMT
50colon adenocarcinoma10.0IGF2

Graphical network of the top 20 diseases related to Breast Disease:



Diseases related to breast disease

Clinical Features for Breast Disease

Drugs & Therapeutics for Breast Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Breast Disease

Drug clinical trials:

Search ClinicalTrials for Breast Disease

Search NIH Clinical Center for Breast Disease

Search CenterWatch for Breast Disease

Genetic Tests for Breast Disease

Anatomical Context for Breast Disease

Animal Models for Breast Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Breast Disease

Sources:
51PubMed
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Articles related to Breast Disease:

(show top 50)    (show all 1023)
idTitleAuthorsYear
1
Ischemic heart disease and breast cancer radiotherapy: the way forward. (24166032)
2014
2
Benign breast disease. (23464687)
2013
3
Isolated post-transplantation lymphoproliferative disease involving the breast and axilla as peripheral T-cell lymphoma. (24043963)
2013
4
Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease. (24375250)
2013
5
Predictors of disease progression in ductal carcinoma in situ of the breast and vascular patterns. (21925705)
2012
6
Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease. (19551864)
2010
7
Intake of fiber and nuts during adolescence and incidence of proliferative benign breast disease. (20229245)
2010
8
Prenatal exposure to cigarette smoke and benign breast disease. (20631621)
2010
9
Image DNA cytometry in FNABs of Libyan breast disease. (20150633)
2010
10
Mammography and ultrasound in the evaluation of male breast disease. (20571799)
2010
11
Endoscopic thyroidectomy via breast approach for patients with Graves' disease. (20556611)
2010
12
Therapeutic breast cancer vaccines: a new strategy for early-stage disease. (19754218)
2009
13
Childbearing, breastfeeding, other reproductive factors and the subsequent risk of hospitalization for gallbladder disease. (18775873)
2009
14
Everything for patients with breast disease--in one place. (19785357)
2009
15
A randomized controlled trial of calcium plus vitamin D supplementation and risk of benign proliferative breast disease. (18853250)
2009
16
History of benign breast disease and risk of breast cancer among women in China: a case-control study. (18347922)
2008
17
Incidence of mondor disease in breast augmentation: a retrospective study of 2052 breasts using inframammary incision. (18626336)
2008
18
Breast disease: benign and malignant. (18721655)
2008
19
Family physicians expedite diagnosis of breast disease in urban minority women. (17204735)
2007
20
Introduction to breast disease review issue on metastasis. (17473361)
2006-2007
21
Determinants of early distant metastatic disease in elderly patients with breast cancer. (16920425)
2006
22
CASE 4. Fibrocystic breast disease in a 16-year-old female with PTEN hamartoma tumor syndrome. (16421431)
2006
23
Serum CYFRA 21-1 (cytokeratin-19 fragments) is a useful tumour marker for detecting disease relapse and assessing treatment efficacy in breast cancer. (15280913)
2004
24
Mammaglobin A, a novel marker of minimal residual disease in early stages breast cancer. (15254674)
2004
25
Different proliferative activity of the glandular and myoepithelial lineages in benign proliferative and early malignant breast diseases. (15254552)
2004
26
Patient notes: fibrocystic breast disease. (14587208)
2003
27
Ultrasound in the management of breast disease. (12628086)
2003
28
von Willebrand factor antigen levels in plasma of patients with malignant breast disease. (11514835)
2001
29
HER-2/neu amplification in benign breast disease and the risk of subsequent breast cancer. (10637239)
2000
30
Autologous graft-versus-host disease induction in advanced breast cancer: role of peripheral blood progenitor cells. (11076645)
2000
31
Breast disease. Introduction. (15687588)
2000
32
Urokinase plasminogen activator: a prognostic marker in breast cancer including patients with axillary node-negative disease. (9625040)
1998
33
Retinoic acid receptors alpha, beta and gamma, and cellular retinol binding protein-I expression in breast fibrocystic disease and cancer. (9368510)
1997
34
Computed model of gadolinium enhanced MRI of breast disease. (9097052)
1997
35
Insulin-like growth factor binding protein-3 and insulin receptor substrate-1 in breast cancer: correlation with clinical parameters and disease-free survival. (9815544)
1997
36
Mammographic features after conservation therapy for malignant breast disease: serial findings standardized by regression analysis. (8659366)
1996
37
The Revlon/UCLA Breast Center Practice Guidelines for the Treatment of Breast Disease. (9166491)
1996
38
Impact of fine-needle aspiration cytology, ultrasonography and mammography on open biopsy rate in patients with benign breast disease. (8665216)
1996
39
The additive effect of peripheral blood stem cells, harvested with low-dose cyclophosphamide, to autologous bone marrow reinfusion on hematopoietic reconstitution after ablative chemotherapy in breast cancer patients with localized disease. (8669878)
1995
40
Mitogenic effect of the 15-kDa gross cystic disease fluid protein (GCDFP-15) on breast-cancer cell lines and on immortal mammary cells. (7829219)
1995
41
Diabetic fibrous breast disease: a clinical entity that mimics cancer. (7720901)
1995
42
Proliferating cell nuclear antigen (PCNA) expression in patients with breast carcinoma in comparison to patients with benign breast diseases. (7772736)
1994
43
P53 gene mutations in women with breast cancer and a previous history of benign breast disease. (7917542)
1994
44
Benign breast disease. (8286685)
1993
45
Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival. (1395002)
1992
46
Serum prolactin levels in women with gross cystic breast disease. (1491178)
1992
47
Type 1 IGF receptor in human breast diseases. (1421425)
1992
48
Paget's disease of the breast with underlying carcinoma arising in systemic scleroderma. (2836488)
1988
49
Anovulation and increased androgenic activity as breast cancer risk in women with fibrocystic disease of the breast. (679211)
1978
50
Mondor's disease. A superficial phlebitis of the breast. (14481707)
1962

Genetic Variations for Breast Disease

Expression for genes affiliated with Breast Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Breast Disease

Search GEO for disease gene expression data for Breast Disease.

Pathways for genes affiliated with Breast Disease

Sources:
54Reactome, 50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 52QIAGEN
See all sources

Pathways related to Breast Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5ESR1, SULT1E1
2
Hide members
10.5PGR, PRLR
310.5KLK3, TFF1, ESR1
4
Acetaminophen metabolism
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10.4CYP1A1, NAT2, SULT1E1
5
Estrone metabolism
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10.4COMT, CYP1A1, SULT1E1
610.4PRL, ERBB2, PRLR
7
Development Prolactin receptor signaling
Hide members
10.4ERBB2, ESR1, PRLR, PRL, CTSD
8
Hide members
10.4PRL, PRLR, PGR, ERBB2, ESR1
9
Hide members
10.4CYP1B1, COMT, CYP1A1, SULT1E1
10
Hide members
10.4PRL, PRLR, IGF2, ERBB2
11
Hide members
10.4CYP1A1, CYP1B1, NAT2, COMT
12
Hide members
10.4CYP1B1, CYP1A1, COMT, NAT2, SULT1E1
13
Hide members
10.4CYP1B1, SULT1E1, NAT2, CYP1A1, COMT

Compounds for genes affiliated with Breast Disease

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Breast Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 182)
idCompoundScoreTop Affiliating Genes
1estrogen4510.9KLK3
2cycloheximide4510.9KLK3, TFF1
3estrone sulfate45 2411.9PRL, SULT1E1, ESR1, CTSD, IGF2, CYP1B1
4progestins4510.8IGF2, ESR1, SULT1E1, PGR, PRLR, PIP
5progestin4510.8ESR1, ERBB2, SULT1E1, PGR, IGF2, PRLR
64-hydroxytamoxifen4510.8TFF1, CTSD, IGF2, CYP1A1, ERBB2, PGR
7toremifene45 1111.8PRL, ESR1, ERBB2, PGR, CYP1A1, TFF1
8fulvestrant45 50 29 1113.8TFF1, PGR, CYP1A1, COMT, ERBB2, ESR1
9flutamide45 60 1112.8ESR1, PRL, KLK3, CYP1A1, CYP1B1, PGR
10dihydrotestosterone45 29 11 2413.8PGR, KLK3, APOD, PIP, PRL, ESR1
11megestrol acetate4510.8KLK3, IGF2, PGR, ERBB2, ESR1
12resveratrol45 60 11 2413.8TFF1, PGR, SULT1E1, ERBB2
13diethylstilbestrol45 29 1112.8ESR1, PGR, SULT1E1, KLK3, COMT, TFF1
14estrone45 29 11 2413.8SULT1E1, PGR, CYP1A1, IGF2, COMT, CYP1B1
15paclitaxel45 50 1112.8ESR1, ERBB2, KRT19, CYP1B1, CTSD, IGF2
16genistein45 29 60 2 11 2415.8ERBB2, ESR1, TFF1, PRLR, CTSD, SULT1E1
17exemestane50 45 60 1113.8IGF2, CYP1B1, PGR, ERBB2, ESR1
18paraffin4510.8KLK3, APOD, ESR1, ERBB2, KRT19, PGR
1917beta-hydroxysteroid4510.8ESR1, PGR, CYP1B1, KRT19, COMT, SULT1E1
20letrozole45 50 60 1113.8CYP1B1, PGR, ERBB2, ESR1, TFF1
21steroid4510.8ESR1, ERBB2, SULT1E1, KRT19, PGR, CYP1B1
22p0024510.8TFF1, ERBB2, KRT19, CYP1B1, IGF2, CTSD
23androstenedione45 2411.8PIP, CYP1B1, CYP1A1, COMT, TFF1, IGF2
24estradiol45 11 2412.8IGF2, PRLR, PRL, PIP, TFF1, CTSD
252-hydroxyestradiol45 2411.8ESR1, CYP1A1, COMT, CYP1B1
26tamoxifen45 50 29 1113.8PGR, ERBB2, COMT, APOD, CYP1B1, CYP1A1
275fluorouracil4510.8PGR, CYP1B1, CTSD, PSG2, ERBB2
28dexamethasone45 50 29 1113.8CYP1A1, NAT2, CYP1B1, KLK3, TFF1, PRLR
29vegf4510.8KLK3, ESR1, ERBB2, PSG2, IGF2, CYP1A1
30formaldehyde45 2411.7PSG2, CTSD, CYP1A1, CYP1B1, KRT19, ERBB2
31testosterone45 60 11 2413.7ESR1, ERBB2, SULT1E1, KRT19, PGR, CYP1B1
32progesterone45 60 29 11 2414.7ESR1, ERBB2, KRT19, PGR, NAT2, CYP1B1
33gnrh4510.7KLK3, PRL, IGF2, PGR, ERBB2, PRLR
34anastrozole45 1111.7IGF2, ESR1, ERBB2, PGR
35docetaxel45 50 60 1113.7ESR1, PGR, NAT2, KLK3, CYP1B1, ERBB2
36leuprolide acetate4510.7ESR1, KLK3, PRL, PGR
37cyclophosphamide45 50 1112.7CTSD, CYP1A1, PGR, ERBB2, ESR1, CYP1B1
384-methoxyestradiol4510.7COMT, CYP1A1, CYP1B1
39retinoic acid45 2411.7CTSD, KRT19, PGR, CYP1B1, APOD, CYP1A1
40doxorubicin45 50 1112.7KLK3, ESR1, ERBB2, PGR, CYP1B1, CTSD
41taxane4510.6KLK3, PGR, ERBB2, ESR1
42valine4510.6ERBB2, CYP1B1, CYP1A1, IGF2, CTSD, COMT
43gefitinib45 50 1112.6ESR1, ERBB2, CYP1A1, IGF2, KLK3
44levonorgestrel45 60 29 1113.6PGR, ESR1, IGF2, PRL
45clozapine45 29 50 1113.5APOD, PRL, CYP1A1, CYP1B1, COMT
462-hydroxyestrone4510.5ESR1, CYP1B1, COMT
47indole-3-carbinol4510.4ESR1, CYP1B1, KLK3, CYP1A1
48lactate4510.4CTSD, PSG2, IGF2, CYP1A1, KRT19, ERBB2
49steroidal4510.4TFF1, CTSD, PGR, ESR1
50adriamycin4510.2PSG2, CTSD, PGR

GO Terms for genes affiliated with Breast Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Breast Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.4IGF2, PRLR, PRL, PIP, CTSD, PSG2

Biological processes related to Breast Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:00680510.6SULT1E1, NAT2, CYP1B1, CYP1A1, COMT
2female pregnancyGO:00756510.5COMT, PSG2, PRL, SULT1E1
3response to estradiol stimulusGO:03235510.5TFF1, PRL, ESR1
4omega-hydroxylase P450 pathwayGO:09726710.5CYP1B1, CYP1A1
5response to drugGO:04249310.4CYP1A1, PRL, APOD, COMT
6epoxygenase P450 pathwayGO:01937310.4CYP1A1, CYP1B1
7estrogen metabolic processGO:00821010.2COMT, SULT1E1

Molecular functions related to Breast Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00549610.5ESR1, SULT1E1, PGR

Products for genes affiliated with Breast Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Breast Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet