MCID: BRS051
MIFTS: 47

Breast Disease malady

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Summaries for Breast Disease

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MalaCards based summary: Breast Disease, also known as breast diseases, is related to breast cancer and breast cyst. An important gene associated with Breast Disease is CTSD (cathepsin D), and among its related pathways are Selected targets of ESR1 and LKB1 signaling events. The compounds chlormadinone acetate and mibolerone have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and testes, and related mouse phenotypes are tumorigenesis and integument.

Aliases & Classifications for Breast Disease

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Breast Disease, Aliases & Descriptions:

Name: Breast Disease 8
 
Breast Diseases 62


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Disease Ontology8 DOID:3463
NCIt39 C26709
MeSH34 D001941

Related Diseases for Breast Disease

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Diseases related to Breast Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.8ANGPT2, CTSD, ESR1, PGR
2breast cyst30.7CTSD, KLK3
3li-fraumeni syndrome30.6CTSD, ESR1, PGR
4ductal carcinoma in situ30.4PGR, ESR1
5cerebral meningioma10.5PGR
6ovarian disease10.4ESR1
7penile disease10.4KLK3, PRL
8sexual disorder10.4KLK3, PRL
9impotence10.3PRL, KLK3
10cribriform carcinoma10.3ESR1, PGR
11progesterone resistance10.3ESR1, PGR
12mammary paget's disease10.3ESR1, PGR
13malignant mixed mullerian tumor10.3ESR1, PGR
14bilateral breast cancer10.3ESR1, PGR
15male breast cancer10.3PGR, ESR1
16bone cancer10.3KLK3, CTSD
17leiomyomatosis10.3PGR, ESR1
18adenosarcoma10.3ESR1, PGR
19myoma10.3PGR, ESR1
20endometrial stromal sarcoma10.3ESR1, PGR
21adenosquamous carcinoma10.3PGR, CTSD
22inflammatory breast carcinoma10.3ESR1, PGR
23lymphangioleiomyomatosis10.3ESR1, PGR
24angiomyolipoma10.3ESR1, PGR
25cervical adenocarcinoma10.2PGR, ESR1
26smooth muscle tumor10.2PGR, ESR1
27factor vii deficiency10.2KLK3, ESR1
28prostatitis10.2
29breast cancer, invasive ductal10.2CTSD, PGR, ESR1
30tubular adenocarcinoma10.2PGR, ESR1, CTSD
31breast ductal carcinoma10.2CTSD, ESR1, PGR
32uterine fibroid10.2PGR, ESR1
33breast fibroadenoma10.2CTSD, ESR1, PGR
34lysosomal storage disease10.2CTSD, ARSA
35prolactinoma10.2PRL, ESR1
36meningioma10.2CTSD, PGR, ESR1
37leiomyoma10.1PGR, ESR1
38hypogonadism10.0PRL, KLK3
39psychotic disorder10.0PRL, ARSA
40gynecomastia10.0ESR1, KLK3, PRL, PGR
41mastitis10.0
42ovarian cancer10.0CTSD, PGR, ESR1
43factor v leiden thrombophilia10.0ANGPT2, CTSD, KLK3
44endometriosis9.9PGR, ANGPT2, ESR1
45breast reconstruction9.9
46obesity9.9
47polycystic ovary syndrome9.9
48cervicitis9.9
49thyroiditis9.9
50endometrial carcinoma9.8ESR1, ANGPT2, PGR, CTSD

Graphical network of the top 20 diseases related to Breast Disease:



Diseases related to breast disease

Symptoms for Breast Disease

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Drugs & Therapeutics for Breast Disease

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Drug clinical trials:

Search ClinicalTrials for Breast Disease

Search NIH Clinical Center for Breast Disease

Genetic Tests for Breast Disease

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Anatomical Context for Breast Disease

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MalaCards organs/tissues related to Breast Disease:

32
Breast, Prostate, Testes, Lymph node, Ovary, Thyroid, Skin, Endothelial

Animal Models for Breast Disease or affiliated genes

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MGI Mouse Phenotypes related to Breast Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7XRCC2, PRL, ESR1, PGR
2MP:00107717.6PGR, ESR1, PRL, ANGPT2, XRCC2
3MP:00053877.2CTSD, ARSA, MT-ND2, ANGPT2, PRL, ESR1
4MP:00053767.0PGR, ESR1, PRL, ANGPT2, XRCC2, CTSD

Publications for Breast Disease

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Articles related to Breast Disease:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
Surgical resident experience in breast disease: a national study. (24449411)
2014
2
Contribution of emotional distance and reserve in patient-physician communication in healthy study patients, and in patients with benign breast disease and breast cancer: a prospective case-control study in Finland. (24596371)
2014
3
Goitre is associated with benign breast disease: a meta-analysis. (23600902)
2013
4
Predicting the likelihood of nonsentinel lymph node metastases in triple negative breast cancer patients with a positive sentinel lymph node: Turkish Federation of Breast Disease Associations protocol MF09-01. (22130034)
2012
5
Angiopoietins 1 and 2 and Tie-2 receptor expression in human ductal breast disease. (21884204)
2011
6
Unilateral breastfeeding: an unusual practice that might be the reason for future development of contralateral breast disease. (21457081)
2011
7
Prospective study of adolescent alcohol consumption and risk of benign breast disease in young women. (20385629)
2010
8
Technology as a force for improved diagnosis and treatment of breast disease. (20646402)
2010
9
Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease. (19551864)
2010
10
Immunolocalization of estrogen-producing and metabolizing enzymes in benign breast disease: comparison with normal breast and breast carcinoma. (20682005)
2010
11
The Diagnostic Accuracy of Mammography and Ultrasound in the Evaluation of Male Breast Disease: A New Algorithm. (20877664)
2009
12
Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease. (19623180)
2009
13
Benign breast disease heterogeneity: association with histopathology, age, and ethnicity. (17917807)
2008
14
Breast cancer incidence in a cohort of women with benign breast disease from a multiethnic, primary health care population. (17319851)
2007
15
Personality predicts quality of life six months after the diagnosis and treatment of breast disease. (17146739)
2007
16
Male breast disease. (15664102)
2005
17
Adolescent diet and incidence of proliferative benign breast disease. (14652275)
2003
18
The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions. (14580249)
2003
19
A clinicopathological review of 34 cases of inflammatory breast disease showing an association between corynebacteria infection and granulomatous mastitis. (12745457)
2003
20
The diagnosis and management of pre-invasive breast disease: radiological diagnosis. (12927034)
2003
21
Diagnostic accuracy of stereotactic large-core needle biopsy for nonpalpable breast disease: results of a multicenter prospective study with 95% surgical confirmation. (12115488)
2002
22
Differential distribution of soluble and complexed forms of prostate-specific antigen in cyst fluids of women with gross cystic breast disease. (11291110)
2001
23
von Willebrand factor antigen levels in plasma of patients with malignant breast disease. (11514835)
2001
24
Presentation and diagnosis of adolescent breast disease. (14965614)
2001
25
Association between polycystic ovary and fibrocystic breast disease. (11223709)
2001
26
Breast Disease-Related Educational Outcomes at the University of Florida. (11348357)
2000
27
A cohort study of oral contraceptive use and risk of benign breast disease. (10389751)
1999
28
Differential display, subtractive hybridization, and application of methodology to search for point mutations to identify genetic defects responsible for progression in MCF10AT model of human breast disease. (10197431)
1999
29
Temporal sampling requirements for the tracer kinetics modeling of breast disease. (9839990)
1998
30
Cyclin D1 gene amplification and protein expression in benign breast disease and breast carcinoma. (9831206)
1998
31
Three-dimensional shaded-surface rendering of MR images of the breast: technique, applications, and impact on surgical management of breast disease. (9536491)
1998
32
Erosive adenomatosis of the nipple: a benign imitator of malignant breast disease. (9040979)
1997
33
Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue. (8879683)
1996
34
Mammographic features after conservation therapy for malignant breast disease: serial findings standardized by regression analysis. (8659366)
1996
35
In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. (8574967)
1996
36
Image-guided core biopsy in patients with breast disease. (8944459)
1996
37
Guidelines for surgeons in the management of symptomatic breast disease in the United Kingdom. (8608845)
1996
38
beta-Endorphin expression in gross cystic breast disease. (7889528)
1995
39
Cytokeratin intermediate filament expression in benign and malignant breast disease. (7535804)
1995
40
GnRH analogs in benign breast disease and breast cancer chemoprevention. A challenge for the year 2000. (8005138)
1994
41
Proliferating cell nuclear antigen (PCNA) expression in patients with breast carcinoma in comparison to patients with benign breast diseases. (7772736)
1994
42
Breast disease in elderly women. (8108765)
1994
43
Imaging techniques for breast disease. (7842561)
1994
44
Xenograft model of progressive human proliferative breast disease. (8411256)
1993
45
Breast disease and the general surgeon. II. Effect of audit on the referral of patients with breast problems. (8476191)
1993
46
Proliferative and nonproliferative breast disease in atomic bomb survivors. Results of a histopathologic review of autopsy breast tissue. (8348497)
1993
47
Immunocytochemical detection of carcinoembryonic antigen in fine-needle aspirates from patients with diverse breast diseases. (8261842)
1993
48
Identification of the major protein components in breast secretions from women with benign and malignant breast diseases. (1727390)
1992
49
Immunohistochemical evidence of vimentin in fibrocystic breast disease and mammary carcinoma]. (1329942)
1992
50
Progestin treatment depresses estrogen receptor but not cathepsin D levels in needle aspirates of benign breast disease. (1756273)
1991

Variations for Breast Disease

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Expression for genes affiliated with Breast Disease

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Expression patterns in normal tissues for genes affiliated with Breast Disease

Search GEO for disease gene expression data for Breast Disease.

Pathways for genes affiliated with Breast Disease

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Pathways related to Breast Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CTSD, ESR1
29.8ESR1, CTSD
3
Show member pathways
FOXA transcription factor networks37
9.7KLK3, ESR1
4
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.7ESR1, PGR
5
Show member pathways
Nuclear Receptors37
9.7ESR1, PGR
6
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.4ESR1, PRL, CTSD
7
Show member pathways
9.3PRL, ESR1, PGR
8
Show member pathways
9.3PRL, ESR1, PGR

Compounds for genes affiliated with Breast Disease

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Compounds related to Breast Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1chlormadinone acetate4410.1PGR, KLK3
2mibolerone44 2811.1KLK3, PGR
3ici 1643844410.1ESR1, PGR
4norgestrel4410.1KLK3, PGR
5idoxifene4410.1PGR, ESR1
6megestrol44 1111.1KLK3, PGR
7triphenylethylene4410.0ESR1, PGR
8ment4410.0KLK3, ESR1
9r18814410.0KLK3, PGR
10norgestimate44 1110.9ESR1, PGR
11buserelin44 28 1111.9PRL, KLK3, PGR
12medroxyprogesterone44 50 28 24 1113.8ESR1, PGR
13cyproteroneacetate449.8PRL, KLK3, PGR
14goserelin44 28 1111.8PGR, ESR1, KLK3
15trilostane44 1110.8PGR, ESR1
16megestrol acetate449.8ESR1, KLK3, PGR
17estradiol benzoate449.8ESR1, PRL, PGR
18steroidal449.8ESR1, CTSD, PGR
19taxane449.8KLK3, ESR1, PGR
20toremifene44 1110.8PRL, ESR1, PGR
21clomiphene citrate449.8PGR, ESR1, PRL
22droloxifene449.8PGR, ESR1
23danazol44 24 1111.8PGR, PRL, ESR1
24diethylstilbestrol44 28 1111.7KLK3, PGR, ESR1
25levonorgestrel44 61 28 1112.7PRL, ESR1, PGR
26progestins449.7PGR, KLK3, ESR1
27leuprolide44 61 28 1112.7PRL, KLK3
28nandrolone44 2410.7PGR, ESR1
29onapristone44 2810.7PGR, ESR1
304-hydroxytamoxifen449.6PGR, ESR1, CTSD
31dhea449.6ARSA, KLK3, PRL
32mifepristone44 28 61 1112.5PRL, PGR, ESR1
33estrone sulfate44 2410.5PRL, ESR1, PGR, CTSD
34leuprolide acetate449.5KLK3, PRL, ESR1, PGR
35flutamide44 61 1111.5KLK3, PRL, ESR1, PGR
36dihydrotestosterone44 28 24 1112.4PRL, KLK3, ESR1, PGR
37gnrh449.4KLK3, PGR, ESR1, PRL
38paclitaxel44 50 1111.4ESR1, CTSD, KLK3, PGR
39tamoxifen44 50 28 1112.4CTSD, PRL, ESR1, PGR
40doxorubicin44 50 1111.3PGR, CTSD, ESR1, KLK3
41estrone44 28 24 1112.3PRL, ESR1, PGR, ARSA
42estradiol44 24 1111.1CTSD, PGR, KLK3, PRL, ESR1
43testosterone44 61 24 1112.1PGR, CTSD, PRL, ESR1, KLK3
44docetaxel44 50 61 1112.1ESR1, KLK3, PGR
45trastuzumab44 50 1111.0ESR1, ANGPT2, CTSD, PGR
46progestin448.7CTSD, ANGPT2, PRL, PGR, ESR1
47paraffin448.7ESR1, ANGPT2, KLK3, CTSD, PGR
48vegf448.6PGR, ESR1, ANGPT2, KLK3, CTSD
49estrogen448.3CTSD, PGR, ANGPT2, KLK3, PRL, ESR1
50steroid447.8ANGPT2, PGR, ESR1, ARSA, CTSD, KLK3

GO Terms for genes affiliated with Breast Disease

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Biological processes related to Breast Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to estrogenGO:0436279.5ARSA, ESR1
2negative regulation of angiogenesisGO:0165259.0KLK3, ANGPT2

Molecular functions related to Breast Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.6ESR1, PGR
2steroid hormone receptor activityGO:0037079.4ESR1, PGR
3protein bindingGO:0055157.3ESR1, PRL, ANGPT2, XRCC2, KLK3, CTSD

Products for genes affiliated with Breast Disease

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Sources for Breast Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet