MCID: BRS051
MIFTS: 56

Breast Disease malady

Summaries for Breast Disease

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32MalaCards
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MalaCards: Breast Disease, also known as breast diseases, is related to breast cancer and prostatitis. An important gene associated with Breast Disease is CTSD (cathepsin D), and among its related pathways are Estrogen biosynthesis and Prolactin receptor signaling. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and lymph node, and related mouse phenotypes are homeostasis/metabolism and tumorigenesis.

Aliases & Classifications for Breast Disease

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
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Aliases & Descriptions:

breast disease 8
breast diseases 60


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Disease Ontology8 DOID:3463
NCIt39 C26709
MeSH34 D001941

Related Diseases for Breast Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Breast Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.2CTSD, TFF1, PIP, PRL, PRLR, CYP1A1
2prostatitis30.4KLK3
3breast cyst30.4KLK3, AZGP1, APOD, CTSD, PIP
4li-fraumeni syndrome30.3ESR1, ERBB2, PIP, PGR
5ductal carcinoma in situ30.2PGR, ERBB2, ESR1
6obesity29.9CTSD, COMT
7polycystic ovary syndrome29.9IGF2, PRL
8prostate cancer29.9ERBB2, IGF2, PIP, CTSD, KLK3
9inflammatory breast carcinoma29.7RHOC, PGR, ERBB2, ESR1
10melanoma29.7COMT, AZGP1, PSG2, RHOC, CYP1A1, CYP1B1
11breast carcinoma in situ10.3
12prostate disease10.3
13in situ carcinoma10.2
14chromosomal disease10.2
15mastitis10.0
16vascular disease10.0
17gallbladder cancer10.0PSG2
18bilateral breast cancer10.0ESR1, PGR
19leiomyoma10.0PGR, ESR1, IGF2, COMT
20breast cancer, invasive ductal10.0CTSD, TFF1, PGR, ERBB2, ESR1
21breast fibroadenoma10.0CTSD, TFF1, PGR, ERBB2, ESR1
22thyroid cancer10.0KRT19
23prostatic hypertrophy10.0KLK3
24myeloma10.0PSG2
25syringoma10.0KRT19
26neuroendocrine tumor10.0PRL
27male breast cancer10.0ESR1, ERBB2, PGR, APOD
28tubular adenocarcinoma10.0ESR1, ERBB2, PGR, CTSD
29leukoplakia10.0CYP1A1
30gynecomastia10.0KLK3, APOD, PRL, PGR, ESR1
31hepatitis10.0NAT2, COMT
32parkinson's disease10.0COMT
33lymphangioleiomyomatosis10.0PGR, ESR1
34coronary heart disease10.0COMT
35hidrocystoma10.0PIP
36cervical cancer10.0PSG2, CTSD, CYP1A1, KRT19
37mammary paget's disease10.0PGR, ERBB2, ESR1
38cerebral meningioma10.0PRLR, PGR
39endometrial carcinoma10.0KLK3, PGR, ERBB2, ESR1
40liver cirrhosis10.0NAT2
41factor vii deficiency10.0KLK3, COMT, PSG2, ERBB2, ESR1
42laryngeal benign neoplasm10.0CTSD, NAT2
43cystic fibrosis10.0NAT2
44hidradenoma10.0PIP
45infertility10.0PIP, PRL, PRLR, CYP1A1, ESR1
46hyperprolactinemia10.0PRLR, PRL
47atherosclerosis10.0CYP1A1, COMT
48oral cancer10.0KRT19, CYP1B1, CYP1A1
49pancreatic cancer10.0PSG2, TFF1, NAT2, KRT19, ERBB2
50pheochromocytoma10.0TFF1, COMT

Graphical network of the top 20 diseases related to Breast Disease:



Diseases related to breast disease

Clinical Features for Breast Disease

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Drugs & Therapeutics for Breast Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Breast Disease

Drug clinical trials:

Search ClinicalTrials for Breast Disease

Search NIH Clinical Center for Breast Disease

Search CenterWatch for Breast Disease

Genetic Tests for Breast Disease

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Anatomical Context for Breast Disease

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32MalaCards
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MalaCards organs/tissues related to Breast Disease:

32
Breast, Prostate, Lymph node, Heart, Testes, Bone, Lung, Ovary, Thyroid, Liver, Endothelial, Bone marrow, T cells, Skin, Colon, Myeloid, Brain, Nk cells

Animal Models for Breast Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Breast Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.6ESR1, COMT, AZGP1, APOD, CTSD, PRL
2MP:000200610.5TFF1, RHOC, PRL, PRLR, CYP1B1, PGR
3MP:000537910.5CTSD, PRLR, KRT19, SULT1E1
4MP:000538910.5PRL, PRLR, NAT2, KRT19, SULT1E1, ERBB2
5MP:000538010.4COMT, PRL, PRLR, IGF2, PGR, KRT19
6MP:000538610.4COMT, APOD, CTSD, PRL, PRLR, IGF2
7MP:000363110.4APOD, CTSD, PRL, PRLR, IGF2, KRT19
8MP:000538710.3COMT, AZGP1, CTSD, RHOC, PRL, IGF2
9MP:001077110.1PRLR, IGF2, KRT19

Publications for Breast Disease

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50PubMed
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Articles related to Breast Disease:

(show top 50)    (show all 1014)
idTitleAuthorsYear
1
Angiosarcoma after breast-conserving therapy: Long-term disease control and late effects with hyperfractionated accelerated re-irradiation (HART). (24345278)
2014
2
Caution for interstitial lung disease as a cause of CA 15-3 rise in advanced breast cancer patients treated with everolimus. (24415627)
2014
3
Dairy intakes in older girls and risk of benign breast disease in young women. (23542805)
2013
4
The hormonal profile of benign breast disease. (23169293)
2013
5
Residual lymph node disease after neoadjuvant chemotherapy predicts an increased risk of lymphedema in node-positive breast cancer patients. (23689935)
2013
6
Ischemic heart disease after breast cancer radiotherapy. (23802527)
2013
7
Serum microRNA-155 as a potential biomarker to track disease in breast cancer. (23071695)
2012
8
Methylated APC and GSTP1 genes in serum DNA correlate with the presence of circulating blood tumor cells and are associated with a more aggressive and advanced breast cancer disease. (20696638)
2010
9
Imaging characteristics of male breast disease. (20560973)
2010
10
Benign breast disease. (20733462)
2010
11
Extremely low excretion of daptomycin into breast milk of a nursing mother with methicillin-resistant Staphylococcus aureus pelvic inflammatory disease. (19249952)
2009
12
Molecular subtypes of breast cancer emerging in young women in Taiwan: evidence for more than just westernization as a reason for the disease in Asia. (19505913)
2009
13
Potential role of tissue microarrays for the study of biomarker expression in benign breast disease and normal breast tissue. (19363445)
2009
14
Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast. (18469796)
2008
15
Prostate-specific antigen in the serum of women with benign breast disease. (17850950)
2008
16
Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease. (19383306)
2007
17
Downregulation of the cyclin-dependent kinase inhibitor p27kip1 might correlate with poor disease-free and overall survival in inflammatory breast cancer. (17092400)
2006
18
Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. (16899602)
2006
19
Male breast disease. (15664102)
2005
20
High gamma-glutamyltransferase (GGT) activity in human breast milk confounds interpretation of high serum GGT activity in a nursing infant with liver disease. (16120961)
2005
21
Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. (16109840)
2005
22
Benign breast disease and the risk of breast cancer. (16034008)
2005
23
Premalignant and in situ breast disease: biology and clinical implications. (16172443)
2005
24
Serum levels of soluble E-selectin are associated with the clinical course of metastatic disease in patients with liver metastases from breast cancer. (15667001)
2004
25
Claudins 2, 3, 4, and 5 in Paget's disease and breast carcinoma. (15619213)
2004
26
Cat-scratch disease presenting as a solitary tumour in the breast: report of three cases. (12551788)
2003
27
Effects of tamoxifen on benign breast disease in women at high risk for breast cancer. (12591986)
2003
28
Synchronous bilateral breast cancer with Paget's disease and invasive ductal carcinoma: report of a case. (12924421)
2003
29
Use of the American College of Radiology BI-RADS to report on the mammographic evaluation of women with signs and symptoms of breast disease. (11818625)
2002
30
Changes in tenascin-C isoform expression in invasive and preinvasive breast disease. (12036947)
2002
31
Selective estrogen receptor modulation and reduction in risk of breast cancer, osteoporosis, and coronary heart disease. (11584060)
2001
32
Possible value of positive PSA levels in malignant and nonmalignant breast diseases]. (11441307)
2001
33
Commentary on Eccles et al.: familial breast cancer: an investigation into the outcome of treatment for early stage disease. (14574000)
2001
34
Benign breast disease. (11594256)
2001
35
Paget's disease of the vulva associated with local adenocarcinoma and previous breast adenocarcinoma: report of two cases. (10417532)
1999
36
Benign breast disease. (10614358)
1999
37
Cowden disease: a cutaneous marker for increased risk of breast cancer. (9930780)
1999
38
Cyclin D1 gene amplification and protein expression in benign breast disease and breast carcinoma. (9831206)
1998
39
Spectrum of breast disease in young females: a retrospective study of 1315 patients. (9866898)
1998
40
Direct action of estrogen on sequence of progression of human preneoplastic breast disease. (9588879)
1998
41
1994 plenary session: imaging symposium. Critical pathways in the management of breast disease: introduction. (7569135)
1995
42
Quantitative parameters measured by a new sonographic method for differentiation of benign and malignant breast disease. (7591649)
1995
43
Sclerodermalike esophageal disease in children of mothers with silicone breast implants. (8078136)
1994
44
Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease and of normal controls. (8261461)
1994
45
Proliferative and nonproliferative breast disease in atomic bomb survivors. Results of a histopathologic review of autopsy breast tissue. (8348497)
1993
46
A clinical and immunologic evaluation of women with silicone breast implants and symptoms of rheumatic disease. (8489106)
1993
47
Prognostic significance of benign proliferative breast disease. (8389654)
1993
48
Current management of primary breast cancer. Part II: Adjuvant therapy and management of stage III disease and in-situ carcinoma. (2175383)
1990
49
A study of a possible association between breast cancer and gallbladder disease. (3946399)
1986
50
Hodgkin's disease simulating inflammatory breast carcinoma on mammography. A case report. (5765939)
1969

Genetic Variations for Breast Disease

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Expression for genes affiliated with Breast Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Disease

Search GEO for disease gene expression data for Breast Disease.

Pathways for genes affiliated with Breast Disease

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53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN
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Pathways related to Breast Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5ESR1, SULT1E1
2
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10.5PGR, PRLR
310.5KLK3, TFF1, ESR1
4
Acetaminophen metabolism
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10.4CYP1A1, NAT2, SULT1E1
5
Estrone metabolism
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10.4COMT, CYP1A1, SULT1E1
610.4PRL, ERBB2, PRLR
7
Development Prolactin receptor signaling
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10.4ERBB2, ESR1, PRLR, PRL, CTSD
8
Hide members
10.4PRL, PRLR, PGR, ERBB2, ESR1
9
Hide members
10.4CYP1B1, COMT, CYP1A1, SULT1E1
10
Hide members
10.4PRL, PRLR, IGF2, ERBB2
11
Hide members
10.4CYP1A1, CYP1B1, NAT2, COMT
12
Hide members
10.4CYP1B1, CYP1A1, COMT, NAT2, SULT1E1
13
Hide members
10.4CYP1B1, SULT1E1, NAT2, CYP1A1, COMT

Compounds for genes affiliated with Breast Disease

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Breast Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 182)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9KLK3
2cycloheximide4410.9KLK3, TFF1
3estrone sulfate44 2411.9PRL, SULT1E1, ESR1, CTSD, IGF2, CYP1B1
4progestins4410.8IGF2, ESR1, SULT1E1, PGR, PRLR, PIP
5progestin4410.8ESR1, ERBB2, SULT1E1, PGR, IGF2, PRLR
64-hydroxytamoxifen4410.8TFF1, CTSD, IGF2, CYP1A1, ERBB2, PGR
7toremifene44 1111.8PRL, ESR1, ERBB2, PGR, CYP1A1, TFF1
8fulvestrant44 49 28 1113.8TFF1, PGR, CYP1A1, COMT, ERBB2, ESR1
9flutamide44 59 1112.8ESR1, PRL, KLK3, CYP1A1, CYP1B1, PGR
10dihydrotestosterone44 28 11 2413.8PGR, KLK3, APOD, PIP, PRL, ESR1
11megestrol acetate4410.8KLK3, IGF2, PGR, ERBB2, ESR1
12resveratrol44 59 11 2413.8TFF1, PGR, SULT1E1, ERBB2
13diethylstilbestrol44 28 1112.8ESR1, PGR, SULT1E1, KLK3, COMT, TFF1
14estrone44 28 11 2413.8SULT1E1, PGR, CYP1A1, IGF2, COMT, CYP1B1
15paclitaxel44 49 1112.8ESR1, ERBB2, KRT19, CYP1B1, CTSD, IGF2
16genistein44 28 59 2 11 2415.8ERBB2, ESR1, TFF1, PRLR, CTSD, SULT1E1
17exemestane49 44 59 1113.8IGF2, CYP1B1, PGR, ERBB2, ESR1
18paraffin4410.8KLK3, APOD, ESR1, ERBB2, KRT19, PGR
1917beta-hydroxysteroid4410.8ESR1, PGR, CYP1B1, KRT19, COMT, SULT1E1
20letrozole44 49 59 1113.8CYP1B1, PGR, ERBB2, ESR1, TFF1
21steroid4410.8ESR1, ERBB2, SULT1E1, KRT19, PGR, CYP1B1
22p0024410.8TFF1, ERBB2, KRT19, CYP1B1, IGF2, CTSD
23androstenedione44 2411.8PIP, CYP1B1, CYP1A1, COMT, TFF1, IGF2
24estradiol44 11 2412.8IGF2, PRLR, PRL, PIP, TFF1, CTSD
252-hydroxyestradiol44 2411.8ESR1, CYP1A1, COMT, CYP1B1
26tamoxifen44 49 28 1113.8PGR, ERBB2, COMT, APOD, CYP1B1, CYP1A1
275fluorouracil4410.8PGR, CYP1B1, CTSD, PSG2, ERBB2
28dexamethasone44 49 28 1113.8CYP1A1, NAT2, CYP1B1, KLK3, TFF1, PRLR
29vegf4410.8KLK3, ESR1, ERBB2, PSG2, IGF2, CYP1A1
30formaldehyde44 2411.7PSG2, CTSD, CYP1A1, CYP1B1, KRT19, ERBB2
31testosterone44 59 11 2413.7ESR1, ERBB2, SULT1E1, KRT19, PGR, CYP1B1
32progesterone44 59 28 11 2414.7ESR1, ERBB2, KRT19, PGR, NAT2, CYP1B1
33gnrh4410.7KLK3, PRL, IGF2, PGR, ERBB2, PRLR
34anastrozole44 1111.7ERBB2, IGF2, ESR1, PGR
35docetaxel44 49 59 1113.7PGR, ERBB2, KLK3, CYP1B1, NAT2, ESR1
36leuprolide acetate4410.7KLK3, PRL, ESR1, PGR
37cyclophosphamide44 49 1112.7ESR1, ERBB2, PGR, CYP1B1, CYP1A1, CTSD
384-methoxyestradiol4410.7COMT, CYP1A1, CYP1B1
39retinoic acid44 2411.7CTSD, KRT19, PGR, CYP1B1, APOD, CYP1A1
40doxorubicin44 49 1112.7ESR1, ERBB2, PGR, CYP1B1, CTSD, PSG2
41taxane4410.6KLK3, PGR, ERBB2, ESR1
42valine4410.6ERBB2, CYP1B1, CYP1A1, IGF2, CTSD, COMT
43gefitinib44 49 1112.6ESR1, ERBB2, CYP1A1, IGF2, KLK3
44levonorgestrel44 59 28 1113.6ESR1, PGR, IGF2, PRL
45clozapine44 28 49 1113.5APOD, CYP1B1, CYP1A1, COMT, PRL
462-hydroxyestrone4410.5COMT, ESR1, CYP1B1
47phenol44 2411.5TFF1, CTSD, NAT2, SULT1E1
48lactate4410.4KRT19, CYP1A1, IGF2, ERBB2, KLK3, CTSD
49steroidal4410.4CTSD, ESR1, TFF1, PGR
50adriamycin4410.2PGR, PSG2, CTSD

GO Terms for genes affiliated with Breast Disease

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Sources:
16Gene Ontology
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Cellular components related to Breast Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.4IGF2, PRLR, PRL, PIP, CTSD, PSG2

Biological processes related to Breast Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:00680510.6SULT1E1, NAT2, CYP1B1, CYP1A1, COMT
2female pregnancyGO:00756510.5COMT, PSG2, PRL, SULT1E1
3response to estradiol stimulusGO:03235510.5TFF1, PRL, ESR1
4omega-hydroxylase P450 pathwayGO:09726710.5CYP1B1, CYP1A1
5response to drugGO:04249310.4CYP1A1, PRL, APOD, COMT
6epoxygenase P450 pathwayGO:01937310.4CYP1A1, CYP1B1
7estrogen metabolic processGO:00821010.2COMT, SULT1E1

Molecular functions related to Breast Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00549610.5ESR1, SULT1E1, PGR

Products for genes affiliated with Breast Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Breast Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet