MCID: BRS051
MIFTS: 56

Breast Disease malady

Summaries for Breast Disease

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32MalaCards
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MalaCards: Breast Disease, also known as breast diseases, is related to breast cancer and prostatitis. An important gene associated with Breast Disease is CTSD (cathepsin D), and among its related pathways are Estrogen biosynthesis and Prolactin receptor signaling. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and lymph node, and related mouse phenotypes are homeostasis/metabolism and tumorigenesis.

Aliases & Classifications for Breast Disease

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
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Aliases & Descriptions:

breast disease 8
breast diseases 60


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Disease Ontology8 DOID:3463
NCIt39 C26709
MeSH34 D001941

Related Diseases for Breast Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Breast Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.2CTSD, TFF1, PIP, PRL, PRLR, CYP1A1
2prostatitis30.4KLK3
3breast cyst30.4KLK3, AZGP1, APOD, CTSD, PIP
4li-fraumeni syndrome30.3ESR1, ERBB2, PIP, PGR
5ductal carcinoma in situ30.2PGR, ERBB2, ESR1
6obesity29.9CTSD, COMT
7polycystic ovary syndrome29.9IGF2, PRL
8prostate cancer29.9ERBB2, IGF2, PIP, CTSD, KLK3
9inflammatory breast carcinoma29.7RHOC, PGR, ERBB2, ESR1
10melanoma29.7COMT, AZGP1, PSG2, RHOC, CYP1A1, CYP1B1
11breast carcinoma in situ10.3
12prostate disease10.3
13in situ carcinoma10.2
14chromosomal disease10.2
15mastitis10.0
16vascular disease10.0
17gallbladder cancer10.0PSG2
18bilateral breast cancer10.0ESR1, PGR
19leiomyoma10.0PGR, ESR1, IGF2, COMT
20breast cancer, invasive ductal10.0CTSD, TFF1, PGR, ERBB2, ESR1
21breast fibroadenoma10.0CTSD, TFF1, PGR, ERBB2, ESR1
22thyroid cancer10.0KRT19
23prostatic hypertrophy10.0KLK3
24myeloma10.0PSG2
25syringoma10.0KRT19
26neuroendocrine tumor10.0PRL
27male breast cancer10.0ESR1, ERBB2, PGR, APOD
28tubular adenocarcinoma10.0ESR1, ERBB2, PGR, CTSD
29leukoplakia10.0CYP1A1
30gynecomastia10.0KLK3, APOD, PRL, PGR, ESR1
31hepatitis10.0NAT2, COMT
32parkinson's disease10.0COMT
33lymphangioleiomyomatosis10.0PGR, ESR1
34coronary heart disease10.0COMT
35hidrocystoma10.0PIP
36cervical cancer10.0PSG2, CTSD, CYP1A1, KRT19
37mammary paget's disease10.0PGR, ERBB2, ESR1
38cerebral meningioma10.0PRLR, PGR
39endometrial carcinoma10.0KLK3, PGR, ERBB2, ESR1
40liver cirrhosis10.0NAT2
41factor vii deficiency10.0KLK3, COMT, PSG2, ERBB2, ESR1
42laryngeal benign neoplasm10.0CTSD, NAT2
43cystic fibrosis10.0NAT2
44hidradenoma10.0PIP
45infertility10.0PIP, PRL, PRLR, CYP1A1, ESR1
46hyperprolactinemia10.0PRLR, PRL
47atherosclerosis10.0CYP1A1, COMT
48oral cancer10.0KRT19, CYP1B1, CYP1A1
49pancreatic cancer10.0PSG2, TFF1, NAT2, KRT19, ERBB2
50pheochromocytoma10.0TFF1, COMT

Graphical network of the top 20 diseases related to Breast Disease:



Diseases related to breast disease

Clinical Features for Breast Disease

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Drugs & Therapeutics for Breast Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Breast Disease

Drug clinical trials:

Search ClinicalTrials for Breast Disease

Search NIH Clinical Center for Breast Disease

Search CenterWatch for Breast Disease

Genetic Tests for Breast Disease

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Anatomical Context for Breast Disease

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32MalaCards
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MalaCards organs/tissues related to Breast Disease:

32
Breast, Prostate, Lymph node, Heart, Testes, Bone, Lung, Liver, Thyroid, Ovary, Endothelial, T cells, Bone marrow, Skin, Colon, Brain, Myeloid, Nk cells

Animal Models for Breast Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Breast Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.6ESR1, COMT, AZGP1, APOD, CTSD, PRL
2MP:000200610.5TFF1, RHOC, PRL, PRLR, CYP1B1, PGR
3MP:000537910.5CTSD, PRLR, KRT19, SULT1E1
4MP:000538910.5PRL, PRLR, NAT2, KRT19, SULT1E1, ERBB2
5MP:000538010.4COMT, PRL, PRLR, IGF2, PGR, KRT19
6MP:000538610.4COMT, APOD, CTSD, PRL, PRLR, IGF2
7MP:000363110.4APOD, CTSD, PRL, PRLR, IGF2, KRT19
8MP:000538710.3COMT, AZGP1, CTSD, RHOC, PRL, IGF2
9MP:001077110.1PRLR, IGF2, KRT19

Publications for Breast Disease

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50PubMed
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Articles related to Breast Disease:

(show top 50)    (show all 1014)
idTitleAuthorsYear
1
Ischemic heart disease after breast cancer radiotherapy. (23802526)
2013
2
Role of HGF in epithelial-stromal cell interactions during progression from benign breast disease to ductal carcinoma in situ. (24025166)
2013
3
Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma. (22864623)
2013
4
Newcastle disease virus Malaysian strain AF2240 induces apoptosis in MCF-7 human breast carcinoma cells at an early stage of the virus life cycle. (23337979)
2013
5
Predicting the likelihood of nonsentinel lymph node metastases in triple negative breast cancer patients with a positive sentinel lymph node: Turkish Federation of Breast Disease Associations protocol MF09-01. (22130034)
2012
6
Electrically active immune-mediated rippling muscle disease preceding breast cancer. (22549359)
2012
7
Clinical Pearls in breast disease. (22980163)
2012
8
Early-onset breast disease: case of a Grave condition with a favorable prognosis. (22837803)
2012
9
Birth outcome in women with breast cancer, cutaneous malignant melanoma, or Hodgkin's disease: a review. (21326655)
2011
10
Unilateral breastfeeding: an unusual practice that might be the reason for future development of contralateral breast disease. (21457081)
2011
11
Measurement of pessimism: hopelessness scale in healthy study subjects, and in patients with benign breast disease and breast cancer: a prospective case-control study in Finland. (22110236)
2011
12
Assessment of 'cancer-prone personality' characteristics in healthy study subjects and in patients with breast disease and breast cancer using the commitment questionnaire: a prospective case-control study in Finland. (22110235)
2011
13
Mammaglobin and maspin transcripts in blood may reflect disease progression and the effect of therapy in breast cancer. (20092039)
2010
14
Image presentation. Sonographic appearances of benign and malignant male breast disease with mammographic and pathologic correlation. (20498468)
2010
15
CXCL12/SDF1 expression by breast cancers is an independent prognostic marker of disease-free and overall survival. (19646861)
2009
16
Nipple aspirate fluid collection, related factors and relationship between carcinoembryonic antigen in nipple aspirate fluid and breast diseases in women in Harbin, PRC. (19273481)
2009
17
Metastatic eyelid disease associated with primary breast carcinoma: case report. (19668974)
2009
18
Nuclear morphometry in FNABs of breast disease in Libyans. (19192660)
2008
19
Immunohistochemical expression of GCIP in breast carcinoma: relationship with tumour grade, disease-free survival, mucinous differentiation and response to chemotherapy. (18983464)
2008
20
Rosai-Dorfman disease presenting as a male breast mass. (17375792)
2007
21
Positive and negative prognostic variables for patients undergoing spine surgery for metastatic breast disease. (17486376)
2007
22
Family physicians expedite diagnosis of breast disease in urban minority women. (17204735)
2007
23
Introduction to breast disease review issue on metastasis. (17473361)
2006-2007
24
Analysis of the mononuclear inflammatory cell infiltrate in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas: preliminary observations. (16935972)
2006
25
Benign breast disease and breast cancer. (16251545)
2005
26
Comparison of HER-2 overexpression in primary breast cancer and metastatic sites and its effect on biological targeting therapy of metastatic disease. (16106267)
2005
27
Ablative techniques in the treatment of benign and malignant breast disease. (12892821)
2003
28
Radiotherapy in early breast disease: current status and perspectives. (12569345)
2003
29
Oxidative DNA damage and repair in a cell lineage model of human proliferative breast disease (PBD). (12805649)
2003
30
The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ. (12927036)
2003
31
Medical radiation, family history of cancer, and benign breast disease in relation to breast cancer risk in young women, USA. (12420949)
2002
32
Evaluation of leukocyte arylsulfatase-A activity in patients with breast cancer and benign breast disease. (11295292)
2001
33
Effects of mammographic density and benign breast disease on breast cancer risk (United States). (11246838)
2001
34
Connective tissue disease and other rheumatic conditions following cosmetic breast implantation in Denmark. (11295960)
2001
35
Intracystic epidermal growth factor level is predictive of breast-cancer risk in women with gross cystic disease of the breast. (11400120)
2001
36
Differential display, subtractive hybridization, and application of methodology to search for point mutations to identify genetic defects responsible for progression in MCF10AT model of human breast disease. (10197431)
1999
37
Transforming growth factor-beta in breast milk: a potential regulator of atopic disease at an early age. (10589009)
1999
38
Case 19. Presentation. Degenerative disc disease at L 4-5, L5-S1 and metastatic breast cancer at L 3. (9492743)
1998
39
Down-regulation of T1A12/mac25, a novel insulin-like growth factor binding protein related gene, is associated with disease progression in breast carcinomas. (9627112)
1998
40
ACOG committee opinion. Role of the obstetrician-gynecologist in the diagnosis and treatment of breast disease. Number 186, September 1997 (replaces no. 140, June 1994). Committee on Gynecologic Practice. American College of Obstetricians and Gynecologists. (9431885)
1997
41
In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. (8574967)
1996
42
Anxiety in patients with symptomatic breast disease: effects of immediate versus delayed communication of results. (8881734)
1996
43
The Revlon/UCLA Breast Center Practice Guidelines for the Treatment of Breast Disease. (9166491)
1996
44
Impact of fine-needle aspiration cytology, ultrasonography and mammography on open biopsy rate in patients with benign breast disease. (8665216)
1996
45
Benign breast disease in Nigerian women: a study of 657 patients. (7861334)
1994
46
Intracystic lipidic profile in fibrocystic breast disease. (7709769)
1994
47
Expression and localization of elements of the plasminogen activation system in benign breast disease and breast cancers. (8227186)
1993
48
Breast cancer risk associated with proliferative breast disease and atypical hyperplasia. (8435803)
1993
49
Immunocytochemical identification of cell types in benign and malignant breast diseases: variations in cell markers accompany the malignant state. (8450194)
1993
50
Surgically confirmed gallbladder disease, venous thromboembolism, and breast tumors in relation to postmenopausal estrogen therapy. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. (4357161)
1974

Genetic Variations for Breast Disease

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Expression for genes affiliated with Breast Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Disease

Search GEO for disease gene expression data for Breast Disease.

Pathways for genes affiliated with Breast Disease

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53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN
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Pathways related to Breast Disease according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5ESR1, SULT1E1
2
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10.5PGR, PRLR
310.5KLK3, TFF1, ESR1
4
Acetaminophen metabolism
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10.4SULT1E1, NAT2, CYP1A1
5
Estrone metabolism
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10.4COMT, CYP1A1, SULT1E1
610.4ERBB2, PRLR, PRL
7
Development Prolactin receptor signaling
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10.4CTSD, PRL, PRLR, ERBB2, ESR1
8
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10.4PRL, PRLR, PGR, ERBB2, ESR1
9
Hide members
10.4COMT, CYP1A1, CYP1B1, SULT1E1
10
Hide members
10.4ERBB2, IGF2, PRLR, PRL
11
Hide members
10.4COMT, CYP1A1, CYP1B1, NAT2
12
Hide members
10.4SULT1E1, NAT2, CYP1B1, CYP1A1, COMT
13
Hide members
10.4SULT1E1, NAT2, CYP1B1, CYP1A1, COMT

Compounds for genes affiliated with Breast Disease

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Breast Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 182)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9KLK3
2cycloheximide4410.9KLK3, TFF1
3estrone sulfate44 2411.9PRL, SULT1E1, ESR1, CTSD, IGF2, CYP1B1
4progestins4410.8IGF2, ESR1, SULT1E1, PGR, PRLR, PIP
5progestin4410.8ESR1, ERBB2, SULT1E1, PGR, IGF2, PRLR
64-hydroxytamoxifen4410.8TFF1, CTSD, IGF2, CYP1A1, ERBB2, PGR
7toremifene44 1111.8PRL, ESR1, ERBB2, PGR, CYP1A1, TFF1
8fulvestrant44 49 28 1113.8TFF1, PGR, CYP1A1, COMT, ERBB2, ESR1
9flutamide44 59 1112.8ESR1, PRL, KLK3, CYP1A1, CYP1B1, PGR
10dihydrotestosterone44 28 11 2413.8PGR, KLK3, APOD, PIP, PRL, ESR1
11megestrol acetate4410.8KLK3, IGF2, PGR, ERBB2, ESR1
12resveratrol44 59 11 2413.8TFF1, PGR, SULT1E1, ERBB2
13diethylstilbestrol44 28 1112.8ESR1, PGR, SULT1E1, KLK3, COMT, TFF1
14estrone44 28 11 2413.8SULT1E1, PGR, CYP1A1, IGF2, COMT, CYP1B1
15paclitaxel44 49 1112.8ESR1, ERBB2, KRT19, CYP1B1, CTSD, IGF2
16genistein44 28 59 2 11 2415.8ERBB2, ESR1, TFF1, PRLR, CTSD, SULT1E1
17exemestane49 44 59 1113.8IGF2, CYP1B1, PGR, ERBB2, ESR1
18paraffin4410.8KLK3, APOD, ESR1, ERBB2, KRT19, PGR
1917beta-hydroxysteroid4410.8ESR1, PGR, CYP1B1, KRT19, COMT, SULT1E1
20letrozole44 49 59 1113.8CYP1B1, PGR, ERBB2, ESR1, TFF1
21steroid4410.8ESR1, ERBB2, SULT1E1, KRT19, PGR, CYP1B1
22p0024410.8TFF1, ERBB2, KRT19, CYP1B1, IGF2, CTSD
23androstenedione44 2411.8PIP, CYP1B1, CYP1A1, COMT, TFF1, IGF2
24estradiol44 11 2412.8IGF2, PRLR, PRL, PIP, TFF1, CTSD
252-hydroxyestradiol44 2411.8ESR1, CYP1A1, COMT, CYP1B1
26tamoxifen44 49 28 1113.8PGR, ERBB2, COMT, APOD, CYP1B1, CYP1A1
275fluorouracil4410.8PGR, CYP1B1, CTSD, PSG2, ERBB2
28dexamethasone44 49 28 1113.8CYP1A1, NAT2, CYP1B1, KLK3, TFF1, PRLR
29vegf4410.8KLK3, ESR1, ERBB2, PSG2, IGF2, CYP1A1
30formaldehyde44 2411.7PSG2, CTSD, CYP1A1, CYP1B1, KRT19, ERBB2
31testosterone44 59 11 2413.7ESR1, ERBB2, SULT1E1, KRT19, PGR, CYP1B1
32progesterone44 59 28 11 2414.7ESR1, ERBB2, KRT19, PGR, NAT2, CYP1B1
33gnrh4410.7KLK3, PRL, IGF2, PGR, ERBB2, PRLR
34anastrozole44 1111.7ERBB2, IGF2, ESR1, PGR
35docetaxel44 49 59 1113.7PGR, ERBB2, KLK3, CYP1B1, NAT2, ESR1
36leuprolide acetate4410.7KLK3, PRL, ESR1, PGR
37cyclophosphamide44 49 1112.7ESR1, ERBB2, PGR, CYP1B1, CYP1A1, CTSD
384-methoxyestradiol4410.7COMT, CYP1A1, CYP1B1
39retinoic acid44 2411.7CTSD, KRT19, PGR, CYP1B1, APOD, CYP1A1
40doxorubicin44 49 1112.7ESR1, ERBB2, PGR, CYP1B1, CTSD, PSG2
41taxane4410.6KLK3, PGR, ERBB2, ESR1
42valine4410.6ERBB2, CYP1B1, CYP1A1, IGF2, CTSD, COMT
43gefitinib44 49 1112.6ESR1, ERBB2, CYP1A1, IGF2, KLK3
44levonorgestrel44 59 28 1113.6ESR1, PGR, IGF2, PRL
45clozapine44 28 49 1113.5APOD, CYP1B1, CYP1A1, COMT, PRL
462-hydroxyestrone4410.5COMT, ESR1, CYP1B1
47phenol44 2411.5TFF1, CTSD, NAT2, SULT1E1
48lactate4410.4KRT19, CYP1A1, IGF2, ERBB2, KLK3, CTSD
49steroidal4410.4CTSD, ESR1, TFF1, PGR
50adriamycin4410.2PGR, PSG2, CTSD

GO Terms for genes affiliated with Breast Disease

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16Gene Ontology
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Cellular components related to Breast Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.4IGF2, PRLR, PRL, PIP, CTSD, PSG2

Biological processes related to Breast Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:00680510.6SULT1E1, NAT2, CYP1B1, CYP1A1, COMT
2female pregnancyGO:00756510.5COMT, PSG2, PRL, SULT1E1
3response to estradiol stimulusGO:03235510.5TFF1, PRL, ESR1
4omega-hydroxylase P450 pathwayGO:09726710.5CYP1B1, CYP1A1
5response to drugGO:04249310.4CYP1A1, PRL, APOD, COMT
6epoxygenase P450 pathwayGO:01937310.4CYP1A1, CYP1B1
7estrogen metabolic processGO:00821010.2COMT, SULT1E1

Molecular functions related to Breast Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00549610.5ESR1, SULT1E1, PGR

Products for genes affiliated with Breast Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Breast Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet