MCID: BRS051
MIFTS: 47

Breast Disease malady

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Summaries for Breast Disease

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33MalaCards
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MalaCards: Breast Disease, also known as breast diseases, is related to breast cancer and breast cyst. An important gene associated with Breast Disease is CTSD (cathepsin D), and among its related pathways are Selected targets of ESR1 and LKB1 signaling events. The compounds chlormadinone acetate and mibolerone have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and testes, and related mouse phenotypes are tumorigenesis and integument.

Aliases & Classifications for Breast Disease

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8Disease Ontology, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM, 40NCIt
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Aliases & Descriptions:

breast disease 8
breast diseases 62


External Ids:

Disease Ontology8 DOID:3463
MeSH35 D001941
NCIt40 C26709

Related Diseases for Breast Disease

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17GeneCards, 18GeneDecks
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Diseases related to Breast Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.0ANGPT2, CTSD, ESR1, PGR
2breast cyst30.3CTSD, KLK3
3li-fraumeni syndrome30.3CTSD, ESR1, PGR
4ductal carcinoma in situ30.1PGR, ESR1
5prostatitis10.2
6cerebral meningioma10.1PGR
7ovarian disease10.1ESR1
8penile disease10.1KLK3, PRL
9sexual disorder10.1KLK3, PRL
10impotence10.1PRL, KLK3
11cribriform carcinoma10.1ESR1, PGR
12progesterone resistance10.1ESR1, PGR
13mammary paget's disease10.1ESR1, PGR
14malignant mixed mullerian tumor10.1ESR1, PGR
15bilateral breast cancer10.1ESR1, PGR
16male breast cancer10.1PGR, ESR1
17bone carcinoma10.1KLK3, CTSD
18leiomyomatosis10.1PGR, ESR1
19adenosarcoma10.1ESR1, PGR
20myoma10.1PGR, ESR1
21endometrial stromal sarcoma10.1ESR1, PGR
22adenosquamous carcinoma10.1PGR, CTSD
23inflammatory breast carcinoma10.1ESR1, PGR
24lymphangioleiomyomatosis10.1ESR1, PGR
25angiomyolipoma10.1ESR1, PGR
26cervical adenocarcinoma10.1PGR, ESR1
27smooth muscle tumor10.1PGR, ESR1
28factor vii deficiency10.1KLK3, ESR1
29breast cancer, invasive ductal10.0CTSD, PGR, ESR1
30tubular adenocarcinoma10.0PGR, ESR1, CTSD
31uterine fibroid10.0PGR, ESR1
32breast fibroadenoma10.0CTSD, ESR1, PGR
33lysosomal storage disease10.0CTSD, ARSA
34prolactinoma10.0PRL, ESR1
35meningioma10.0CTSD, PGR, ESR1
36leiomyoma10.0PGR, ESR1
37hypogonadism10.0PRL, KLK3
38psychotic disorder10.0PRL, ARSA
39mastitis10.0
40gynecomastia10.0ESR1, KLK3, PRL, PGR
41ovarian cancer10.0CTSD, PGR, ESR1
42factor v leiden thrombophilia10.0ANGPT2, CTSD, KLK3
43endometriosis10.0PGR, ANGPT2, ESR1
44endometrial carcinoma10.0ESR1, ANGPT2, PGR, CTSD
45prostate cancer9.9ESR1, CTSD, ANGPT2, KLK3
46adenocarcinoma9.9KLK3, ANGPT2, ESR1, PGR, CTSD
47breast reconstruction9.9
48polycystic ovary syndrome9.9
49cervicitis9.9
50obesity9.9

Graphical network of the top 20 diseases related to Breast Disease:



Diseases related to breast disease

Symptoms for Breast Disease

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Drugs & Therapeutics for Breast Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Breast Disease

Search NIH Clinical Center for Breast Disease

Genetic Tests for Breast Disease

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Anatomical Context for Breast Disease

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33MalaCards
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MalaCards organs/tissues related to Breast Disease:

33
Breast, Prostate, Testes, Lymph node, Ovary, Thyroid, Skin, Endothelial

Animal Models for Breast Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Breast Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7XRCC2, PRL, ESR1, PGR
2MP:00107717.6PGR, ESR1, PRL, ANGPT2, XRCC2
3MP:00053877.2CTSD, ARSA, MT-ND2, ANGPT2, PRL, ESR1
4MP:00053767.0PGR, ESR1, PRL, ANGPT2, XRCC2, CTSD

Publications for Breast Disease

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Sources:
52PubMed
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Articles related to Breast Disease:

(show top 50)    (show all 515)
idTitleAuthorsYear
1
Goitre is associated with benign breast disease: a meta-analysis. (23600902)
2013
2
A Multiantigen Vaccine Targeting Neu, IGFBP-2, and IGF-IR Prevents Tumor Progression in Mice with Preinvasive Breast Disease. (24154719)
2013
3
Predicting the likelihood of nonsentinel lymph node metastases in triple negative breast cancer patients with a positive sentinel lymph node: Turkish Federation of Breast Disease Associations protocol MF09-01. (22130034)
2012
4
Angiopoietins 1 and 2 and Tie-2 receptor expression in human ductal breast disease. (21884204)
2011
5
Unilateral breastfeeding: an unusual practice that might be the reason for future development of contralateral breast disease. (21457081)
2011
6
Prospective study of adolescent alcohol consumption and risk of benign breast disease in young women. (20385629)
2010
7
Technology as a force for improved diagnosis and treatment of breast disease. (20646402)
2010
8
Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease. (19551864)
2010
9
Immunolocalization of estrogen-producing and metabolizing enzymes in benign breast disease: comparison with normal breast and breast carcinoma. (20682005)
2010
10
The Diagnostic Accuracy of Mammography and Ultrasound in the Evaluation of Male Breast Disease: A New Algorithm. (20877664)
2009
11
Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease. (19623180)
2009
12
Benign breast disease heterogeneity: association with histopathology, age, and ethnicity. (17917807)
2008
13
Breast cancer incidence in a cohort of women with benign breast disease from a multiethnic, primary health care population. (17319851)
2007
14
Personality predicts quality of life six months after the diagnosis and treatment of breast disease. (17146739)
2007
15
Male breast disease. (15664102)
2005
16
Adolescent diet and incidence of proliferative benign breast disease. (14652275)
2003
17
The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions. (14580249)
2003
18
A clinicopathological review of 34 cases of inflammatory breast disease showing an association between corynebacteria infection and granulomatous mastitis. (12745457)
2003
19
The diagnosis and management of pre-invasive breast disease: radiological diagnosis. (12927034)
2003
20
Diagnostic accuracy of stereotactic large-core needle biopsy for nonpalpable breast disease: results of a multicenter prospective study with 95% surgical confirmation. (12115488)
2002
21
Differential distribution of soluble and complexed forms of prostate-specific antigen in cyst fluids of women with gross cystic breast disease. (11291110)
2001
22
von Willebrand factor antigen levels in plasma of patients with malignant breast disease. (11514835)
2001
23
Presentation and diagnosis of adolescent breast disease. (14965614)
2001
24
Association between polycystic ovary and fibrocystic breast disease. (11223709)
2001
25
Breast Disease-Related Educational Outcomes at the University of Florida. (11348357)
2000
26
A cohort study of oral contraceptive use and risk of benign breast disease. (10389751)
1999
27
Differential display, subtractive hybridization, and application of methodology to search for point mutations to identify genetic defects responsible for progression in MCF10AT model of human breast disease. (10197431)
1999
28
Differentiation of benign versus malignant breast disease. (10207498)
1999
29
Temporal sampling requirements for the tracer kinetics modeling of breast disease. (9839990)
1998
30
Cyclin D1 gene amplification and protein expression in benign breast disease and breast carcinoma. (9831206)
1998
31
Three-dimensional shaded-surface rendering of MR images of the breast: technique, applications, and impact on surgical management of breast disease. (9536491)
1998
32
Erosive adenomatosis of the nipple: a benign imitator of malignant breast disease. (9040979)
1997
33
Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue. (8879683)
1996
34
Mammographic features after conservation therapy for malignant breast disease: serial findings standardized by regression analysis. (8659366)
1996
35
In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. (8574967)
1996
36
Image-guided core biopsy in patients with breast disease. (8944459)
1996
37
Guidelines for surgeons in the management of symptomatic breast disease in the United Kingdom. (8608845)
1996
38
beta-Endorphin expression in gross cystic breast disease. (7889528)
1995
39
Cytokeratin intermediate filament expression in benign and malignant breast disease. (7535804)
1995
40
GnRH analogs in benign breast disease and breast cancer chemoprevention. A challenge for the year 2000. (8005138)
1994
41
Proliferating cell nuclear antigen (PCNA) expression in patients with breast carcinoma in comparison to patients with benign breast diseases. (7772736)
1994
42
Breast disease in elderly women. (8108765)
1994
43
Imaging techniques for breast disease. (7842561)
1994
44
Xenograft model of progressive human proliferative breast disease. (8411256)
1993
45
Breast disease and the general surgeon. II. Effect of audit on the referral of patients with breast problems. (8476191)
1993
46
Proliferative and nonproliferative breast disease in atomic bomb survivors. Results of a histopathologic review of autopsy breast tissue. (8348497)
1993
47
Immunocytochemical detection of carcinoembryonic antigen in fine-needle aspirates from patients with diverse breast diseases. (8261842)
1993
48
Identification of the major protein components in breast secretions from women with benign and malignant breast diseases. (1727390)
1992
49
Immunohistochemical evidence of vimentin in fibrocystic breast disease and mammary carcinoma]. (1329942)
1992
50
Progestin treatment depresses estrogen receptor but not cathepsin D levels in needle aspirates of benign breast disease. (1756273)
1991

Variations for Breast Disease

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Expression for genes affiliated with Breast Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Disease

Search GEO for disease gene expression data for Breast Disease.

Pathways for genes affiliated with Breast Disease

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Sources:
50PathCards, 12EMD Millipore, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 30KEGG
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Pathways related to Breast Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CTSD, ESR1
29.8ESR1, CTSD
3
Show member pathways
FOXA transcription factor networks38
9.7KLK3, ESR1
4
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.7ESR1, PGR
5
Show member pathways
Nuclear Receptors38
9.7ESR1, PGR
6
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.4ESR1, PRL, CTSD
7
Show member pathways
9.3PRL, ESR1, PGR
8
Show member pathways
9.3PRL, ESR1, PGR

Compounds for genes affiliated with Breast Disease

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience
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Compounds related to Breast Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1chlormadinone acetate4510.1PGR, KLK3
2mibolerone45 2911.1KLK3, PGR
3ici 1643844510.1ESR1, PGR
4norgestrel4510.1KLK3, PGR
5idoxifene4510.1PGR, ESR1
6megestrol45 1111.1KLK3, PGR
7triphenylethylene4510.0ESR1, PGR
8ment4510.0KLK3, ESR1
9r18814510.0KLK3, PGR
10norgestimate45 1110.9ESR1, PGR
11buserelin45 29 1111.9PRL, KLK3, PGR
12medroxyprogesterone45 51 29 24 1113.8ESR1, PGR
13cyproteroneacetate459.8PRL, KLK3, PGR
14goserelin45 29 1111.8PGR, ESR1, KLK3
15trilostane45 1110.8PGR, ESR1
16megestrol acetate459.8ESR1, KLK3, PGR
17estradiol benzoate459.8ESR1, PRL, PGR
18steroidal459.8ESR1, CTSD, PGR
19taxane459.8KLK3, ESR1, PGR
20toremifene45 1110.8PRL, ESR1, PGR
21clomiphene citrate459.8PGR, ESR1, PRL
22droloxifene459.8PGR, ESR1
23danazol45 24 1111.8PGR, PRL, ESR1
24diethylstilbestrol45 29 1111.7KLK3, PGR, ESR1
25levonorgestrel45 61 29 1112.7PRL, ESR1, PGR
26progestins459.7PGR, KLK3, ESR1
27leuprolide45 61 29 1112.7PRL, KLK3
28nandrolone45 2410.7PGR, ESR1
29onapristone45 2910.7PGR, ESR1
304-hydroxytamoxifen459.6PGR, ESR1, CTSD
31dhea459.6ARSA, KLK3, PRL
32mifepristone45 29 61 1112.5PRL, PGR, ESR1
33estrone sulfate45 2410.5PRL, ESR1, PGR, CTSD
34leuprolide acetate459.5KLK3, PRL, ESR1, PGR
35flutamide45 61 1111.5KLK3, PRL, ESR1, PGR
36dihydrotestosterone45 29 24 1112.4PRL, KLK3, ESR1, PGR
37gnrh459.4KLK3, PGR, ESR1, PRL
38paclitaxel45 51 1111.4ESR1, CTSD, KLK3, PGR
39tamoxifen45 51 29 1112.4CTSD, PRL, ESR1, PGR
40doxorubicin45 51 1111.3PGR, CTSD, ESR1, KLK3
41estrone45 29 24 1112.3PRL, ESR1, PGR, ARSA
42estradiol45 24 1111.1CTSD, PGR, KLK3, PRL, ESR1
43testosterone45 61 24 1112.1PGR, CTSD, PRL, ESR1, KLK3
44docetaxel45 51 61 1112.1ESR1, KLK3, PGR
45trastuzumab45 51 1111.0ESR1, ANGPT2, CTSD, PGR
46progestin458.7CTSD, ANGPT2, PRL, PGR, ESR1
47paraffin458.7ESR1, ANGPT2, KLK3, CTSD, PGR
48vegf458.6PGR, ESR1, ANGPT2, KLK3, CTSD
49estrogen458.3CTSD, PGR, ANGPT2, KLK3, PRL, ESR1
50steroid457.8ANGPT2, PGR, ESR1, ARSA, CTSD, KLK3

GO Terms for genes affiliated with Breast Disease

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16Gene Ontology
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Biological processes related to Breast Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to estrogenGO:0436279.5ARSA, ESR1
2negative regulation of angiogenesisGO:0165259.0KLK3, ANGPT2

Molecular functions related to Breast Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.6ESR1, PGR
2steroid hormone receptor activityGO:0037079.4ESR1, PGR
3protein bindingGO:0055157.3ESR1, PRL, ANGPT2, XRCC2, KLK3, CTSD

Products for genes affiliated with Breast Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Breast Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet