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MCID: BRS053

Breast Fibroadenoma malady
13 genes, 1 tissue, 117 related diseases, clinical trials.

Summaries for Breast Fibroadenoma

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59Wikipedia, 29MalaCards
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Wikipedia:59 Fibroadenomas of the breast are lumps composed of fibrous and glandular tissue. Because breast cancer... more...

MalaCards: Breast Fibroadenoma, also known as fibroadenoma, is related to breast cancer and gynecomastia. An important gene associated with Breast Fibroadenoma is HIF1A (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)), and among its related pathways are Angiogenesis and JAK2 phosphorylation. The compounds flutamide and trastuzumab have been mentioned in the context of this disorder. Affiliated tissues include breast and breast, and related mouse phenotypes are nervous system and reproductive system.

Aliases & Classifications for Breast Fibroadenoma

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8Disease Ontology, 10DISEASES, 41Novoseek, 56UMLS, 52SNOMED-CT, 36NCIt
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Aliases & Descriptions:

breast fibroadenoma 8 10 41
fibroadenoma 8 41 56
juvenile fibroadenoma of breast 8 56
fibroadenoma of breast 8 56
complex fibroadenoma of the breast 8
complex fibroadenoma of breast 8
fibroadenoma, no icd-o subtype 8
juvenile fibroadenoma 8
cellular fibroadenoma 8
complex fibroadenoma 56
fibroadenoma nos 8



Related Diseases for Breast Fibroadenoma

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16GeneCards, 17GeneDecks
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Diseases related to breast fibroadenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer27.6ESR1, PRLR, PRL, ERBB2, CYP19A1, PGR
2gynecomastia26.2PRL, CYP19A1, ESR1, PGR
3li-fraumeni syndrome25.6ESR1, ERBB2, PGR, CYP19A1, PRLR
4arthritis13.7FGF1
5rheumatoid arthritis13.6PRLR
6tongue cancer13.6PRLR
7alzheimer's disease13.6FGF1
8leydig cell tumor13.6CYP19A1
9obesity13.6HIF1A
10osteoarthritis13.6FGF1
11neuroendocrine tumor13.4PRL
12uterine carcinosarcoma13.4ERBB2
13craniopharyngioma13.4PRL
14aromatase deficiency13.4CYP19A1
15sertoli-leydig cell tumor13.4PGR
16pheochromocytoma13.4FGF1, HIF1A
17hypertension13.4PRL
18hereditary leiomyomatosis and renal cell cancer13.4PGR
19cushing's syndrome13.3PRL
20hemangioma13.2VIM
21gastrointestinal stromal tumor13.2VIM
22angiosarcoma13.2VIM
23chordoma13.1VIM
24hyperprolactinemia13.1PRLR, PRL
25rhabdomyosarcoma13.1VIM
26alveolar soft part sarcoma13.1VIM
27neuroblastoma13.1VIM
28kidney cancer13.0VIM
29cerebral meningioma13.0PGR, PRLR
30bladder carcinoma13.0FGF1, ERBB2
31uterine sarcoma13.0ESR1, CYP19A1
32leukemia13.0FGF1, PRLR, FGFR4
33wilms tumor13.0VIM
34fragile x-associated primary ovarian insufficiency13.0CYP19A1, PRL
35secretory meningioma13.0VIM
36polycystic ovary syndrome13.0PRL, CYP19A1
37uterine adnexa cancer13.0CYP19A1, ESR1
38ependymoma12.9VIM
39cervical cancer12.9HIF1A
40giant cell tumor12.9VIM
41pituitary cancer12.9PRL
42estrogen excess12.9CYP19A1, PGR
43osteosarcoma12.9ESR1, FGF1, HIF1A
44retinoblastoma12.9ERBB2, ESR1
45pituitary adenoma12.9PRLR, PRL, FGFR4
46sarcoma12.9FGFR4, VIM
47prostate cancer12.9FGF1, ERBB2, HIF1A
48colorectal cancer12.9HIF1A, PRLR, ERBB2
49prolactinoma12.9PRL, ESR1
50gastric cancer12.9FGF1, ERBB2, HIF1A

Graphical network of the top 20 diseases related to breast fibroadenoma:



Diseases related to breast fibroadenoma

Symptoms for Breast Fibroadenoma

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Drugs & Therapeutics for Breast Fibroadenoma

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Sources:
5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials, 56UMLS, 37NDF-RT
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Approved drugs:

Search CenterWatch for breast fibroadenoma

Drug clinical trials:

Search ClinicalTrials for breast fibroadenoma

Search NIH Clinical Center for breast fibroadenoma

Search CenterWatch for breast fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Anatomical Context for Breast Fibroadenoma

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29MalaCards
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MalaCards organs/tissues related to breast fibroadenoma:

29
Breast

Animal Models for Breast Fibroadenoma or affiliated genes

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33MGI, 26inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to breast fibroadenoma:

33 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
nervous system phenotype
MP:00036319.8ERBB2, PRLR
2
reproductive system phenotype
MP:00053898.6PRLR, VIM, ERBB2, ESR1, PGR
3
limbs/digits/tail phenotype
MP:00053718.5PRLR, ERBB2, ESR1, HIF1A, PGR
4
embryogenesis phenotype
MP:00053808.5PRL, PRLR, VIM, ERBB2, HIF1A, PGR
5
skeleton phenotype
MP:00053908.3CYP19A1, ERBB2, ESR1, HIF1A, PGR, PRLR
6
tumorigenesis
MP:00020068.3PGR, PRL, PRLR, FGFR4, ERBB2, ESR1
7
muscle phenotype
MP:00053698.2VIM, CYP19A1, ERBB2, ESR1, HIF1A, PGR
8
endocrine/exocrine gland phenotype
MP:00053798.2PRL, PRLR, CYP19A1, ERBB2, ESR1, HIF1A
9
integument phenotype
MP:00107718.1PRL, PRLR, CYP19A1, ERBB2, ESR1, HIF1A
10
behavior/neurological phenotype
MP:00053867.6PRL, PRLR, VIM, CYP19A1, ERBB2, ESR1
11
cellular phenotype
MP:00053847.3PRLR, VIM, FGFR4, CYP19A1, ERBB2, ESR1
12
homeostasis/metabolism phenotype
MP:00053767.2PRL, PRLR, VIM, FGFR4, FGF1, CYP19A1

Publications for Breast Fibroadenoma

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47PubMed
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Articles related to breast fibroadenoma:

idTitleAuthorsYearAffiliating Genes
1Characterization of two constitutively active prolact in receptor variants in a cohort of 95 women with multiple breast fibroadenomas . (19897676)Courtillot C.... Touraine P.2010PRLR, PRL
2Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)Zubor P.... Danko J.2008ERBB2
3Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)La Rosa S.... Capella C.2001FGFR4, FGF1
4Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)Pasqualini J.R.... Ruiz A.1997CYP19A1, ARSH

Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Breast Fibroadenoma

Pathways for genes affiliated with Breast Fibroadenoma

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4Cell Signaling Technology, 50Reactome, 34NCBI BioSystems Database, 54Thomson Reuters, 12EMD Millipore, 46PharmGKB, 55Tocris Bioscience, 48QIAGEN
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Pathways related to breast fibroadenoma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Angiogenesis4
10.2FGFR4
2
JAK2 phosphorylation50
Hide members
9.8PRLR, PRL
3
DAG and IP3 signaling50
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9.6FGFR4, FGF1, ERBB2
4
Tyrosine Kinases / Adaptors4
9.6ERBB2, FGF1, FGFR4
5
ErbB4 signaling events34
9.5PRL, PRLR, ERBB2
6
Ovarian Infertility Genes34
9.4PGR, CYP19A1, PRLR
7
Development_Ligand-dependent activation of the ESR1/AP-1 pathway54
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9.4HIF1A, ESR1, PRLR
8
estrogen biosynthesis34
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9.3CYP19A1, CYP19A1, ESR1
9
FBXW7 WD mutants do not bind NICD150
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9.3ESR1, PRLR, PRL
10
Disease50
9.0PRL, FGFR4, FGF1, ERBB2, HIF1A
11
Development_Prolactin receptor signaling54
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8.9PRL, PRLR, ERBB2, ESR1
12
TGF-beta Pathway55
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8.9PRL, PRLR, FGFR4, FGF1, ERBB2
13
Nanog in Mammalian ESC Pluripotency48
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8.6VIM, FGFR4, FGF1, ERBB2, ESR1
14
Rho Family GTPases48
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8.3VIM, FGFR4, FGF1, ERBB2, ESR1, HIF1A
15
PIP3 activates AKT signaling50
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8.0PGR, ESR1, ERBB2, FGF1, FGFR4, PRLR
16
Signaling by GPCR50
Hide members
7.7PRL, PRLR, FGFR4, FGF1, ERBB2, ESR1

Compounds for genes affiliated with Breast Fibroadenoma

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41Novoseek, 11DrugBank, 46PharmGKB, 55Tocris Bioscience, 22HMDB, 2BitterDB
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Compounds related to breast fibroadenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1flutamide41 1111.4PRL
2trastuzumab41 46 1111.9CYP19A1, ERBB2, HIF1A
3methotrexate41 46 55 1112.8CYP19A1, VIM, HIF1A
4idoxifene419.6PGR, CYP19A1, ESR1
5dexamethasone41 46 55 1112.5PGR, PRLR, CYP19A1, PRL
6fadrozole419.4ERBB2, ESR1, CYP19A1
7estradiol benzoate419.3CYP19A1, ESR1, PRL, PGR
8estradiol41 11 2211.3PRLR, ARSH, PRL, CYP19A1
9leuprolide acetate419.3PGR, CYP19A1, ESR1, PRL
10exemestane41 46 1111.3CYP19A1, ERBB2, ESR1, PGR
11megestrol acetate419.2CYP19A1, ESR1, ERBB2, PGR
12anastrozole41 55 1111.2PGR, ERBB2, ESR1, CYP19A1
13clomiphene citrate419.2PGR, ESR1, PRL, CYP19A1
14lapatinib41 46 1111.2CYP19A1, ERBB2, ESR1, PGR
15nandrolone41 2210.2ESR1, PGR, CYP19A1
16letrozole41 46 55 1112.2ERBB2, PGR, ESR1, CYP19A1
17levonorgestrel41 1110.2ESR1, PRL, PGR, CYP19A1
18fulvestrant41 46 1111.2PGR, ESR1, ERBB2, CYP19A1
19norelgestromin41 1110.2ESR1, PGR, ARSH
20taxane419.2PGR, ERBB2, ESR1, CYP19A1
21geldanamycin41 46 1110.9FGF1, PGR, HIF1A, ERBB2, ESR1
22tibolone418.9ESR1, PGR, ARSH, CYP19A1
23toremifene41 119.9ERBB2, CYP19A1, ESR1, PGR, PRL
24hydrocortisone41 2 1110.9ERBB2, FGF1, VIM, PRL, CYP19A1
25docetaxel41 46 1110.9PGR, ERBB2, HIF1A, ESR1, CYP19A1
26steroidal418.8ARSH, PGR, ESR1, CYP19A1
27n-(4-hydroxyphenyl)retinamide418.8ERBB2, CYP19A1, VIM, ESR1
28bisphenol a418.8ESR1, PGR, ARSH, HIF1A, CYP19A1
29progestins418.7PRLR, CYP19A1, PGR, ARSH, ESR1
30cyclophosphamide41 46 1110.7ESR1, PGR, CYP19A1, ERBB2, HIF1A
31danazol41 11 2210.7CYP19A1, PRL, ESR1, PGR, ARSH
32estrone sulfate41 229.7ESR1, PGR, ARSH, PRL, CYP19A1
33raloxifene41 46 1110.6ERBB2, CYP19A1, ESR1, PGR
34estrone41 11 2210.5CYP19A1, ESR1, PRL, ARSH, PGR
3517beta-hydroxysteroid418.5ESR1, PGR, CYP19A1, ARSH
36paclitaxel41 46 1110.3PGR, CYP19A1, ERBB2, ESR1, HIF1A, VIM
37doxorubicin41 46 1110.3ESR1, PGR, VIM, HIF1A, ERBB2, CYP19A1
384-hydroxytamoxifen418.2ARSH, PGR, ERBB2, CYP19A1, VIM, ESR1
39paraffin418.0PGR, VIM, FGFR4, HIF1A, FGF1, PRLR
40dihydrotestosterone41 11 2210.0VIM, ARSH, PRL, HIF1A, ESR1, PGR
41genistein41 2 11 2211.0ESR1, VIM, PGR, HIF1A, PRLR, CYP19A1
42cycloheximide418.0FGF1, ERBB2, VIM, PRLR, ESR1, HIF1A
43arginine417.9HIF1A, ARSH, VIM, FGFR4, FGF1, CYP19A1
44steroid417.6PRLR, CYP19A1, ARSH, PRL, ERBB2, PGR
45progestin417.6ERBB2, PRL, PRLR, VIM, CYP19A1, ESR1
46gnrh417.6ESR1, PRL, CYP19A1, PRLR, VIM, ERBB2
47progesterone41 55 11 2210.5PRL, ARSH, CYP19A1, ERBB2, ESR1, PRLR
48tamoxifen46 41 119.0PGR, FGF1, ARSH, HIF1A, ESR1, ERBB2
49testosterone41 11 229.0HIF1A, ESR1, ERBB2, CYP19A1, FGF1, VIM
50estrogen417.0PRLR, FGF1, ARSH, PGR, HIF1A, ESR1

GO Terms for genes affiliated with Breast Fibroadenoma

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15Gene Ontology
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Biological processes related to breast fibroadenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:0082099.6ESR1, CYP19A1
2organ inductionGO:0017599.6FGF1, FGFR4
3positive regulation of nitric-oxide synthase activityGO:0510009.6HIF1A, ESR1
4lactationGO:0075959.6HIF1A, PRLR, PRL

Products for genes affiliated with Breast Fibroadenoma

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  • Antibodies
  • Proteins
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Sources for Breast Fibroadenoma

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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