MCID: BRS053
MIFTS: 56

Breast Fibroadenoma malady

Genetic diseases, Cancer diseases, Reproductive diseases, Rare diseases categories
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Summaries for Breast Fibroadenoma

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Wikipedia:65 Fibroadenomas of the breast are lumps composed of fibrous and glandular tissue. Because breast cancer... more...

MalaCards based summary: Breast Fibroadenoma, also known as fibroadenoma, is related to ductal carcinoma in situ and myoma. An important gene associated with Breast Fibroadenoma is HIF1A (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)), and among its related pathways are Signaling by FGFR1 mutants and FGF signaling pathway. The compounds fadrozole and idoxifene have been mentioned in the context of this disorder. Affiliated tissues include breast, breast and lung, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Disease Ontology:8 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

Aliases & Classifications for Breast Fibroadenoma

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Breast Fibroadenoma, Aliases & Descriptions:

Name: Breast Fibroadenoma 8 10 44
Fibroadenoma 8 44 62
Juvenile Fibroadenoma of Breast 8 62
Complex Fibroadenoma of Breast 8 62
 
Fibroadenoma of Breast 8 62
Juvenile Fibroadenoma 8
Cellular Fibroadenoma 8


Classifications:



Related Diseases for Breast Fibroadenoma

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Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1ductal carcinoma in situ30.2PGR, ESR1, ERBB2
2myoma30.2CYP19A1, PGR, ESR1
3li-fraumeni syndrome30.1ERBB2, ESR1, PGR
4adenoma30.0PRLR, FGFR4, FGF1, PRL
5gynecomastia29.4ESR1, CYP19A1, PGR, PRL
6breast cancer29.1CYP19A1, ERBB2, HIF1A, PGR, ESR1, FGF1
7breast giant fibroadenoma10.4
8breast pericanalicular fibroadenoma10.4
9multiple fibroadenomas of the breast10.3
10phyllode tumor10.3
11pituitary carcinoma10.3PRL
12myocardial infarction10.3HIF1A, FGF1
13pseudoangiomatous stromal hyperplasia10.2
14endocrine gland cancer10.2ESR1, CYP19A1
15cerebral meningioma10.2PGR, PRLR
16uterine sarcoma10.2CYP19A1, ESR1
17estrogen excess10.2PGR, CYP19A1
18neurofibromatosis10.2
19pleomorphic adenoma10.2FGF1, ERBB2
20sertoli cell tumor10.2CYP19A1, PGR
21abrikosov's tumor10.2CYP19A1, ESR1
22cribriform carcinoma10.2ESR1, PGR
23osteoporosis, postmenopausal10.2CYP19A1, ESR1
24progesterone resistance10.2PGR, ESR1
25bilateral breast cancer10.2ESR1, PGR
26leiomyomatosis10.1PGR, ESR1
27adenosarcoma10.1PGR, ESR1
28uterine fibroid10.1PGR, ESR1
29beckwith-wiedemann syndrome10.1
30hodgkin's lymphoma10.1
31fibroma10.1
32transsexualism10.1
33medulloblastoma10.1
34gastric adenocarcinoma10.1FGF1, HIF1A, ERBB2
35lymphangioleiomyomatosis10.1PGR, ESR1
36angiomyolipoma10.1PGR, ESR1
37squamous cell carcinoma of the head and neck10.1HIF1A, FGFR4, ERBB2
38malignant mixed mullerian tumor10.1ERBB2, PGR
39cervical adenocarcinoma10.1PGR, ESR1
40lung adenocarcinoma10.1HIF1A, ERBB2, FGFR4
41vascular disease10.1ESR1, HIF1A, FGF1
42smooth muscle tumor10.1ESR1, PGR
43hypogonadism, hypergonadotropic10.1CYP19A1, PRL
44breast intracanalicular fibroadenoma10.1
45breast fibroadenosis10.1
46gigantomastia10.1
47ovarian disease10.1PRL, CYP19A1
48anovulation10.1PRL, CYP19A1
49hyperprolactinemia10.1PRL, PRLR
50astrocytoma10.1HIF1A, FGF1, FGFR4

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to breast fibroadenoma

Symptoms for Breast Fibroadenoma

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Drugs & Therapeutics for Breast Fibroadenoma

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Drug clinical trials:

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Search NIH Clinical Center for Breast Fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Anatomical Context for Breast Fibroadenoma

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MalaCards organs/tissues related to Breast Fibroadenoma:

32
Breast, Lung

FMA organs/tissues related to Breast Fibroadenoma:

14
Breast

Animal Models for Breast Fibroadenoma or affiliated genes

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Publications for Breast Fibroadenoma

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Articles related to Breast Fibroadenoma:

(show top 50)    (show all 54)
idTitleAuthorsYear
1
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. (25038752)
2014
2
Ultrasound-guided cryoablation of breast fibroadenoma: a pilot trial. (25408274)
2014
3
High resolution compression elastography and color doppler sonography in characterization of breast fibroadenoma. (25227197)
2014
4
Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)
2013
5
Fine-needle aspiration of gray zone lesions of the breast: fibroadenoma versus ductal carcinoma. (22936545)
2013
6
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
7
Transaxillary approach with use of traction suture for excision of breast fibroadenoma: a new technique and its results. (22604577)
2012
8
A clinical study on the resection of breast fibroadenoma using two types of incision. (22108740)
2011
9
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. (22011321)
2011
10
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue. (22249796)
2011
11
Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. (21733035)
2011
12
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)
2011
13
Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. (21192183)
2011
14
Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. (21875284)
2011
15
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. (22121516)
2011
16
Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. (24376952)
2010
17
Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (19897676)
2010
18
A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. (19211906)
2009
19
Recurrence of giant juvenile breast fibroadenoma in a girl with Turner's syndrome. (19492586)
2009
20
Ectopic breast fibroadenoma of the vulva. (19622961)
2009
21
Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)
2008
22
Invasive mucinous carcinoma arising within breast fibroadenoma. (18841829)
2008
23
Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. (18094894)
2007
24
Breast fibroadenoma in female adolescents. (17206308)
2007
25
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. (16961651)
2006
26
Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. (16297109)
2005
27
Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. (16405127)
2005
28
p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. (15578730)
2005
29
Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. (15450823)
2004
30
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
31
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)
2001
32
Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. (10432878)
1999
33
Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells. (10349403)
1999
34
Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. (9885614)
1999
35
Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. (9278103)
1997
36
Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)
1997
37
Breast fibroadenoma with atypical features: a case report. (8629423)
1996
38
Infarction of breast fibroadenoma in a postmenopausal woman. (8044310)
1994
39
Aspiration cytology of breast fibroadenoma with atypia. (1606889)
1992
40
Medulloblastoma metastasizing to a breast fibroadenoma: a case report. (2021436)
1991
41
Possibilities of the conventional and interventional sonography in diagnosis of breast fibroadenoma. (1841055)
1991
42
Risk factors for breast fibroadenoma in young women. (2766721)
1989
43
Carcinoma in a breast fibroadenoma. (3473866)
1987
44
Estrogen receptor in dissociated and cultured human breast fibroadenoma epithelial cells. (3828977)
1987
45
Morphometry of the breast fibroadenoma. (3562341)
1986
46
Management of breast fibroadenoma in women under 25 years of age. (3730963)
1986
47
A radiodiagnostic study of breast fibroadenoma. (2949499)
1985
48
Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells. (6164351)
1980
49
Breast fibroadenoma and cardiac anomaly associated with EMG (Beckwith-Wiedemann) syndrome. (430311)
1979
50
The myoepithelium in human breast fibroadenoma. (4452932)
1974

Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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Expression patterns in normal tissues for genes affiliated with Breast Fibroadenoma

Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

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Pathways related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8FGFR4, FGF1
29.8FGFR4, FGF1
39.6FGFR4, ERBB2
4
Show member pathways
9.5ESR1, CYP19A1
5
Show member pathways
9.5FGFR4, FGF1, HIF1A
69.5FGFR4, FGF1, HIF1A
7
Show member pathways
Nuclear Receptors37
9.3ESR1, PGR
89.3HIF1A, ERBB2, FGF1
99.2PRL, PRLR
109.2PRL, PRLR
11
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.2HIF1A, ESR1, PRLR
12
Show member pathways
9.2FGFR4, FGF1, ERBB2
13
Show member pathways
9.2FGFR4, FGF1, ERBB2
14
Show member pathways
9.2ERBB2, FGF1, FGFR4
159.2FGFR4, FGF1, ERBB2
169.1ESR1, ERBB2, FGF1
179.0CYP19A1, PGR, PRLR
188.8FGF1, ERBB2, ESR1, HIF1A
198.7PRL, PRLR, ERBB2
20
Show member pathways
8.7FGFR4, FGF1, ERBB2, ESR1
21
Show member pathways
8.7ESR1, ERBB2, FGF1, FGFR4
228.5PRL, PRLR, FGF1, FGFR4
23
Show member pathways
8.4HIF1A, ESR1, ERBB2, FGF1, FGFR4
24
Show member pathways
8.4FGFR4, ERBB2, PRLR, PRL
25
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
8.2ERBB2, PRLR, PRL, ESR1
268.1HIF1A, PRL, ERBB2, FGF1, FGFR4
27
Show member pathways
8.1PGR, ESR1, PRL, PRLR
28
Show member pathways
8.0PRL, PRLR, ERBB2, FGF1, FGFR4
29
Show member pathways
8.0PRL, PRLR, ERBB2, FGF1, FGFR4
30
Show member pathways
6.9FGFR4, FGF1, ERBB2, PRLR, PRL, ESR1
31
Show member pathways
6.6HIF1A, PGR, ESR1, PRL, PRLR, ERBB2

Compounds for genes affiliated with Breast Fibroadenoma

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Compounds related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 128)
idCompoundScoreTop Affiliating Genes
1fadrozole449.2ESR1, ERBB2, CYP19A1
2idoxifene449.2ESR1, PGR, CYP19A1
3nandrolone44 249.9PGR, ESR1, CYP19A1
4tibolone448.9CYP19A1, PGR, ESR1, ARSH
5steroidal448.8ARSH, PGR, CYP19A1, ESR1
6goserelin44 28 1110.8PGR, ESR1, CYP19A1
7megestrol acetate448.8ERBB2, PGR, CYP19A1, ESR1
817beta-hydroxysteroid448.8CYP19A1, ARSH, PGR, ESR1
9exemestane44 50 61 1111.7CYP19A1, ESR1, PGR, ERBB2
10anastrozole44 50 1110.7CYP19A1, PGR, ERBB2, ESR1
11lapatinib44 50 1110.7ERBB2, CYP19A1, ESR1, PGR
12nomegestrol acetate448.7PGR, ESR1, ARSH
13fulvestrant44 50 28 1111.7ERBB2, PGR, CYP19A1, ESR1
14bisphenol a448.7ARSH, PGR, HIF1A, CYP19A1, ESR1
15letrozole44 50 61 1111.7CYP19A1, PGR, ESR1, ERBB2
16taxane448.7CYP19A1, PGR, ESR1, ERBB2
17progestins448.6ARSH, PRLR, CYP19A1, PGR, ESR1
18raloxifene44 50 28 1111.5ERBB2, ESR1, CYP19A1, PGR
19geldanamycin44 50 61 1111.5FGF1, ERBB2, ESR1, HIF1A, PGR
20estradiol benzoate448.5CYP19A1, PGR, PRL, ESR1
21trastuzumab44 50 1110.5HIF1A, CYP19A1, PGR, ESR1, ERBB2
22leuprolide acetate448.5ESR1, PRL, CYP19A1, PGR
234-hydroxytamoxifen448.4PGR, CYP19A1, ESR1, ERBB2, ARSH
24clomiphene citrate448.4PGR, CYP19A1, ESR1, PRL
25levonorgestrel44 61 28 1111.4CYP19A1, PGR, PRL, ESR1
26docetaxel44 50 61 1111.3ERBB2, ESR1, PGR, HIF1A, CYP19A1
27flutamide44 61 1110.3PGR, ESR1, PRL, CYP19A1
28cyclophosphamide44 50 1110.3ERBB2, ESR1, PGR, HIF1A, CYP19A1
29methotrexate50 44 1110.2ERBB2, CYP19A1, ESR1, HIF1A, PGR
30danazol44 24 1110.2PRL, CYP19A1, PGR, ARSH, ESR1
315fluorouracil448.2ESR1, ERBB2, PGR, CYP19A1, HIF1A
32estrone sulfate44 249.2ARSH, PRL, ESR1, PGR, CYP19A1
33estrone44 28 24 1111.1PGR, PRL, CYP19A1, ARSH, ESR1
34paclitaxel44 50 1110.1HIF1A, PGR, CYP19A1, ESR1, ERBB2
35toremifene44 119.0ERBB2, ESR1, PGR, CYP19A1, PRL
36dihydrotestosterone44 28 24 1110.9ESR1, HIF1A, ARSH, PRL, PGR, CYP19A1
37paraffin447.8PRLR, FGFR4, FGF1, ERBB2, ESR1, PGR
38vegf447.8FGFR4, HIF1A, FGF1, ERBB2, ESR1, PGR
39genistein44 28 61 2 24 1112.7PGR, PRLR, HIF1A, CYP19A1, ERBB2, FGF1
40cycloheximide447.7PRLR, FGF1, ERBB2, CYP19A1, HIF1A, ESR1
41arginine447.6FGF1, ARSH, CYP19A1, HIF1A, PRL, ERBB2
42estradiol44 24 119.6ARSH, ESR1, CYP19A1, PGR, PRLR, PRL
43dexamethasone44 50 28 1110.3PRL, PGR, CYP19A1, HIF1A, PRLR, ERBB2
44progestin447.3ESR1, CYP19A1, PGR, ARSH, ERBB2, PRLR
45gnrh447.2ERBB2, PRLR, ARSH, CYP19A1, PGR, ESR1
46progesterone44 28 61 24 1111.2ARSH, ERBB2, PRL, PRLR, CYP19A1, ESR1
47steroid447.2CYP19A1, PGR, ESR1, PRL, ARSH, ERBB2
48tamoxifen44 50 28 119.6PRL, ERBB2, ARSH, FGF1, ESR1, HIF1A
49testosterone44 61 24 119.6CYP19A1, ARSH, HIF1A, PGR, ESR1, PRL
50estrogen446.6ESR1, PRL, PGR, PRLR, ERBB2, ARSH

GO Terms for genes affiliated with Breast Fibroadenoma

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Biological processes related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1organ inductionGO:00175910.0FGFR4, FGF1
2positive regulation of nitric-oxide synthase activityGO:0510009.9ESR1, HIF1A
3androgen metabolic processGO:0082099.7CYP19A1, ESR1
4steroid biosynthetic processGO:0066949.6PRLR, CYP19A1
5positive regulation of epithelial cell proliferationGO:0506799.6FGF1, ERBB2
6phosphatidylinositol-mediated signalingGO:0480159.5ERBB2, FGF1, FGFR4
7fibroblast growth factor receptor signaling pathwayGO:0085439.4FGFR4, FGF1, ERBB2
8Fc-epsilon receptor signaling pathwayGO:0380959.3FGFR4, FGF1, ERBB2
9epidermal growth factor receptor signaling pathwayGO:0071739.3ERBB2, FGF1, FGFR4
10lactationGO:0075959.2PRLR, PRL, HIF1A
11JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.1PRLR, PRL
12neurotrophin TRK receptor signaling pathwayGO:0480118.9ERBB2, FGF1, FGFR4
13cell surface receptor signaling pathwayGO:0071668.9ERBB2, PRLR, PRL
14signal transductionGO:0071658.4FGF1, ERBB2, ESR1, PGR, HIF1A

Molecular functions related to Breast Fibroadenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.3ESR1, PGR
2steroid hormone receptor activityGO:0037079.0PGR, ESR1
3enzyme bindingGO:0198998.9ESR1, PGR, HIF1A
4protein bindingGO:0055156.9PGR, ESR1, PRL, PRLR, ERBB2, FGF1

Products for genes affiliated with Breast Fibroadenoma

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Sources for Breast Fibroadenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet