MCID: BRS053
MIFTS: 40

Breast Fibroadenoma malady

Genetic diseases, Cancer diseases, Reproductive diseases, Rare diseases categories

Aliases & Classifications for Breast Fibroadenoma

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 59SNOMED-CT, 42NCIt
See all sources

Aliases & Descriptions for Breast Fibroadenoma:

Name: Breast Fibroadenoma 10 47 12
Fibroadenoma 10 47 65
Juvenile Fibroadenoma of Breast 10 65
Fibroadenoma of Breast 10 65
 
Complex Fibroadenoma of Breast 10
Juvenile Fibroadenoma 10
Cellular Fibroadenoma 10
Complex Fibroadenoma 65


Classifications:



Summaries for Breast Fibroadenoma

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Wikipedia:68 Fibroadenomas of the breast are noncancerous tumors composed of fibrous and glandular tissue. Because... more...

MalaCards based summary: Breast Fibroadenoma, also known as fibroadenoma, is related to breast cyst and breast cancer. An important gene associated with Breast Fibroadenoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways is Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. Affiliated tissues include breast, breast and testes, and related mouse phenotypes are limbs/digits/tail and cardiovascular system.

Disease Ontology:10 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

Related Diseases for Breast Fibroadenoma

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Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1breast cyst30.1CYP19A1, ERBB2, ESR1, PGR
2breast cancer28.7CYP19A1, ERBB2, ESR1, KRT14, KRT8, MKI67
3breast hemangioma27.3ARSH, CYP19A1, ERBB2, ESR1, HMGA2, KRT14
4connective tissue benign neoplasm10.5
5connective tissue cancer10.5
6fibrosarcoma10.5
7solitary fibrous tumor10.5
8breast giant fibroadenoma10.3
9enophthalmos10.3ERBB2, PGR
10heart leiomyosarcoma10.3ERBB2, ESR1
11breast mucinous carcinoma10.3ERBB2, PGR
12estrogen-receptor negative breast cancer10.3ERBB2, PGR
13vulvar melanoma10.3ESR1, PGR
14benign multicystic peritoneal mesothelioma10.3CYP19A1, PGR
15childhood teratocarcinoma of the testis10.3ESR1, PGR
16ciliary body disease10.3ERBB2, ESR1
17rectum rhabdomyosarcoma10.3ESR1, PGR
18vestibulocochlear nerve disease10.3ESR1, PGR
19uterine corpus cancer10.3ERBB2, PGR
20vulvar disease10.3ESR1, PGR
21vulvar sarcoma10.3ESR1, PGR
22tuberous sclerosis10.3ESR1, PGR
23apocrine sweat gland neoplasm10.3ERBB2, PGR
24microscopic colitis10.3ERBB2, PGR
25progesterone resistance10.3ESR1, PGR
26metachronous kidney wilms' tumor10.3ESR1, PGR
27breast leiomyosarcoma10.3ERBB2, PGR
28bartonellosis10.3ESR1, PGR
29oromandibular dystonia10.3ERBB2, KRT8
30anus lymphoma10.3ESR1, PGR
31female breast carcinoma10.3
32breast benign neoplasm10.3
33phyllode tumor10.3
34follicular basal cell carcinoma10.3ESR1, PGR
35breast myoepitheliosis10.3ERBB2, PGR
36central nervous system leiomyosarcoma10.3ESR1, MKI67
37chest wall lymphoma10.3ESR1, PGR
38oxyphilic endometrial endometrioid adenocarcinoma10.3ESR1, PGR
39deep keratitis10.2ESR1, PGR
40peripheral epithelioid sarcoma10.2ESR1, PGR
41oral lichen planus10.2ERBB2, MKI67
42vulvar seborrheic keratosis10.2ESR1, MKI67
43venous hemangioma10.2ESR1, PGR
44placental insufficiency10.2KRT15, KRT8
45metatypical basal cell carcinoma10.2KRT15, KRT8
46hypoglossal nerve neoplasm10.2CYP19A1, ESR1
47breast granular cell tumor10.2ERBB2, ESR1
48germ cell and embryonal cancer10.2CYP19A1, ESR1, PGR
49subclavian steal syndrome10.2CYP19A1, ESR1, PGR
50endometriosis in scar of skin10.2CYP19A1, ESR1, PGR

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to breast fibroadenoma

Symptoms for Breast Fibroadenoma

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Drugs & Therapeutics for Breast Fibroadenoma

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Drugs for Breast Fibroadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TamoxifenapprovedPhase 434110540-29-12733526
Synonyms:
(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene
(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(Para-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine
(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine (IUPAC)
(Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE
(Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
,citrate
1-P-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-Para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-.beta.-Dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
10540-29-1
1ya4
2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
54965-24-1 (citrate)
AC1MBZ3R
Apo-Tamox
Apo-tamox
BIDD:ER0008
BIDD:GT0009
BIDD:PXR0003
BPBio1_000278
BRD-K93754473-001-02-9
BRD-K93754473-048-05-3
BSPBio_000252
BSPBio_001150
BSPBio_001982
C07108
C26H29NO
CCRIS 3275
CHEBI:41774
CHEMBL83
CID2733526
Citofen
Crisafeno
D08559
DB00675
Diemon
EINECS 234-118-0
Gen-Tamoxifen
Gen-tamoxifen
HMS1362J11
HMS1792J11
HMS1990J11
HMS2090N08
HSDB 6782
ICI 47699
ICI-46,474
ICI-47699
IDI1_000258
IDI1_002170
Istubol
Kessar
L024126
LS-393
Lopac0_001203
MLS001332535
MLS001332536
MolPort-003-850-384
 
NCGC00024928-01
NCGC00024928-03
NCGC00024928-04
NCGC00024928-05
NCGC00024928-07
NCGC00024928-08
NCGC00024928-09
NCGC00024928-12
NSC727681
Noltam
Nolvadex
Nolvadex-D
Nourytam
Novaldex
Novo-Tamoxifen
Oncomox
PMS-Tamoxifen
Pms-Tamoxifen
Prestwick2_000146
Prestwick3_000146
QTL1_000079
Retaxim
SMR000059172
ST50511785
Soltamox
Spectrum5_001417
Spectrum5_002043
T5648_SIGMA
TAMOXIFEN (TAMOXIFEN CITRATE (54965-24-1))
TRANS FORM OF TAMOXIFEN
Tamizam
Tamofen
Tamone
Tamoplex (TN)
Tamoxasta
Tamoxen
Tamoxifen
Tamoxifen (INN)
Tamoxifen (TN)
Tamoxifen (Z)
Tamoxifen Citrate
Tamoxifen [INN:BAN]
Tamoxifen and its salts
Tamoxifene
Tamoxifene [INN-French]
Tamoxifeno
Tamoxifeno [INN-Spanish]
Tamoxifenum
Tamoxifenum [INN-Latin]
Tamoxifène
Tocris-0999
Tomaxithen
Trans-Tamoxifen
UNII-094ZI81Y45
UPCMLD-DP027
Valodex
Zemide
cMAP_000044
nchembio.140-comp7
nchembio.76-comp1
nchembio732-comp3
tamoxifen
trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
trans-Tamoxifen
2EfamolPhase 415
3Evening PrimroseNutraceuticalPhase 44

Interventional clinical trials:

(show all 15)
idNameStatusNCT IDPhase
1Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast CancerCompletedNCT00999921Phase 4
2Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)CompletedNCT02011919Phase 2, Phase 3
3Feasibility Study Assessing the Treatment of Fibroadenomata With a Circumferential Sonication Treatment With HIFUActive, not recruitingNCT02139683Phase 3
4MR Guided Focused Ultrasound Surgery in the Treatment of Breast FibroadenomasTerminatedNCT00147108Phase 3
5Treatment of Breast Fibroadenoma With FastScan HIFURecruitingNCT02488655Phase 1
6High Intensity Focused Ultrasound (HIFU) to Treat Breast FibroadenomaCompletedNCT01422629
7ICE-SENSE™ Cryotherapy for Breast Fibroadenoma TrialCompletedNCT00910312
8Treatment of Breast Fibroadenoma With High Intensity Focused UltrasoundRecruitingNCT02078011
9American Breast Laser Ablation Therapy EvaluationRecruitingNCT00807924
10Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)Active, not recruitingNCT01331954
11LOUIS-3D Breast StudyActive, not recruitingNCT01755130
12Optical Tomography With Ultrasound GuidanceActive, not recruitingNCT00908609
13Synthetic Aperture Radar Detection of Breast TumoursEnrolling by invitationNCT02493595
14Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 LesionsNot yet recruitingNCT02638935
15Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood TestNot yet recruitingNCT02066025

Search NIH Clinical Center for Breast Fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Anatomical Context for Breast Fibroadenoma

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MalaCards organs/tissues related to Breast Fibroadenoma:

33
Breast, Testes, Lung

FMA organs/tissues related to Breast Fibroadenoma:

16
Breast

Animal Models for Breast Fibroadenoma or affiliated genes

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MGI Mouse Phenotypes related to Breast Fibroadenoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.3ERBB2, ESR1, HMGA2, MED12, PGR
2MP:00053858.4CYP19A1, ERBB2, ESR1, KRT8, MED12, PGR
3MP:00053898.1CYP19A1, ERBB2, ESR1, HMGA2, KRT14, KRT8
4MP:00020068.0ERBB2, ESR1, KRT14, NME1, PGR, RASSF1
5MP:00107717.3CYP19A1, ERBB2, ESR1, HMGA2, KRT14, MME
6MP:00053766.6CYP19A1, ERBB2, ESR1, HMGA2, KRT14, MME

Publications for Breast Fibroadenoma

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Articles related to Breast Fibroadenoma:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma-a multicenter experience. (25635224)
2015
2
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. (25038752)
2014
3
Ultrasound-guided cryoablation of breast fibroadenoma: a pilot trial. (25408274)
2014
4
High resolution compression elastography and color doppler sonography in characterization of breast fibroadenoma. (25227197)
2014
5
Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)
2013
6
Fine-needle aspiration of gray zone lesions of the breast: fibroadenoma versus ductal carcinoma. (22936545)
2013
7
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
8
Transaxillary approach with use of traction suture for excision of breast fibroadenoma: a new technique and its results. (22604577)
2012
9
A clinical study on the resection of breast fibroadenoma using two types of incision. (22108740)
2011
10
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. (22011321)
2011
11
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue. (22249796)
2011
12
Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. (21733035)
2011
13
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)
2011
14
Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. (21192183)
2011
15
Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. (21875284)
2011
16
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. (22121516)
2011
17
Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. (24376952)
2010
18
Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (19897676)
2010
19
A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. (19211906)
2009
20
Recurrence of giant juvenile breast fibroadenoma in a girl with Turner's syndrome. (19492586)
2009
21
Herb-related aneuploidy in breast fibroadenoma. (21686556)
2009
22
Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)
2008
23
Invasive mucinous carcinoma arising within breast fibroadenoma. (18841829)
2008
24
Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. (18094894)
2007
25
Breast fibroadenoma in female adolescents. (17206308)
2007
26
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. (16961651)
2006
27
Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. (16297109)
2005
28
Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. (16405127)
2005
29
p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. (15578730)
2005
30
Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. (15450823)
2004
31
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
32
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)
2001
33
Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. (10432878)
1999
34
Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells. (10349403)
1999
35
Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. (9885614)
1999
36
Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. (9278103)
1997
37
Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)
1997
38
Breast fibroadenoma with atypical features: a case report. (8629423)
1996
39
Infarction of breast fibroadenoma in a postmenopausal woman. (8044310)
1994
40
Medulloblastoma metastasizing to a breast fibroadenoma: a case report. (2021436)
1991
41
Possibilities of the conventional and interventional sonography in diagnosis of breast fibroadenoma. (1841055)
1991
42
Risk factors for breast fibroadenoma in young women. (2766721)
1989
43
Carcinoma in a breast fibroadenoma. (3473866)
1987
44
Estrogen receptor in dissociated and cultured human breast fibroadenoma epithelial cells. (3828977)
1987
45
Morphometry of the breast fibroadenoma. (3562341)
1986
46
Management of breast fibroadenoma in women under 25 years of age. (3730963)
1986
47
A radiodiagnostic study of breast fibroadenoma. (2949499)
1985
48
Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells. (6164351)
1980
49
Breast fibroadenoma and cardiac anomaly associated with EMG (Beckwith-Wiedemann) syndrome. (430311)
1979
50
The myoepithelium in human breast fibroadenoma. (4452932)
1974

Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

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Pathways related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CYP19A1, ESR1

GO Terms for genes affiliated with Breast Fibroadenoma

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Cellular components related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.9KRT14, KRT15, KRT8
2nucleusGO:00056346.4ERBB2, ESR1, HMGA2, KRT14, KRT15, KRT8

Biological processes related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:00082099.9CYP19A1, ESR1
2intracellular steroid hormone receptor signaling pathwayGO:00305189.6ESR1, MED12

Molecular functions related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:000549610.0ESR1, PGR

Sources for Breast Fibroadenoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet