MCID: BRS053
MIFTS: 48

Breast Fibroadenoma

Categories: Rare diseases, Reproductive diseases, Genetic diseases, Cancer diseases

Aliases & Classifications for Breast Fibroadenoma

MalaCards integrated aliases for Breast Fibroadenoma:

Name: Breast Fibroadenoma 12 51 14
Fibroadenoma 12 51 41 69
Juvenile Fibroadenoma of Breast 12 69
Fibroadenoma of Breast 12 69
Complex Fibroadenoma of Breast 12
Fibroadenoma of the Breast 28
Cellular Fibroadenoma 12
Juvenile Fibroadenoma 12

Classifications:



Summaries for Breast Fibroadenoma

Disease Ontology : 12 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

MalaCards based summary : Breast Fibroadenoma, also known as fibroadenoma, is related to benign breast phyllodes tumor and myoma. An important gene associated with Breast Fibroadenoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Signaling by ERBB4 and Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. The drugs Tamoxifen and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include breast, breast and testes, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 72 Fibroadenomas, are benign breast tumours characterized by an admixture of stromal and epithelial tissue.... more...

Related Diseases for Breast Fibroadenoma

Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 benign breast phyllodes tumor 30.2 MME PGR
2 myoma 29.5 CYP19A1 ESR1 HMGA2 MED12 PGR
3 breast giant fibroadenoma 11.3
4 multiple fibroadenomas of the breast 11.1
5 breast pericanalicular fibroadenoma 11.1
6 scirrhous adenocarcinoma 10.6 ERBB2 PGR
7 breast apocrine carcinoma 10.6 ERBB2 PGR
8 intracystic papillary adenoma 10.5 ERBB2 PGR
9 progesterone-receptor negative breast cancer 10.5 ERBB2 PGR
10 bizarre leiomyoma 10.5 MED12 PGR
11 comedo carcinoma 10.5 ERBB2 ESR1
12 breast osteosarcoma 10.5 ERBB2 KRT8
13 vulvar syringoma 10.5 ESR1 PGR
14 vestibular gland benign neoplasm 10.5 ESR1 PGR
15 lung leiomyoma 10.5 ESR1 PGR
16 bartholin's gland adenoma 10.5 ESR1 PGR
17 vulvar benign neoplasm 10.5 ESR1 PGR
18 benign metastasizing leiomyoma 10.5 CYP19A1 PGR
19 trigonitis 10.5 ESR1 PGR
20 vulvar leiomyoma 10.5 ESR1 PGR
21 uterine body mixed cancer 10.5 ERBB2 PGR
22 progesterone resistance 10.5 ESR1 PGR
23 cribriform carcinoma 10.4 ESR1 PGR
24 microglandular adenosis 10.4 ERBB2 PGR
25 bartholin's gland benign neoplasm 10.4 ESR1 PGR
26 endometrial squamous cell carcinoma 10.4 ESR1 PGR
27 gastric signet ring cell adenocarcinoma 10.4 ESR1 PGR
28 endometrial mucinous adenocarcinoma 10.4 ESR1 PGR
29 adenoid basal cell carcinoma 10.4 ESR1 PGR
30 deep angioma 10.4 ESR1 PGR
31 synchronous bilateral breast carcinoma 10.4 ESR1 PGR
32 intramuscular hemangioma 10.4 ESR1 PGR
33 glycogen-rich clear cell breast carcinoma 10.4 ESR1 PGR
34 retinitis pigmentosa 47 10.4 ESR1 PGR
35 hidrocystoma 10.4 KRT15 KRT8
36 adenomyosis 10.4 ESR1 PGR
37 lobular neoplasia 10.4 ERBB2 ESR1
38 retinitis pigmentosa 20 10.4 ESR1 PGR
39 glassy cell carcinoma of the cervix 10.3 ERBB2 ESR1 PGR
40 breast medullary carcinoma 10.3 ERBB2 ESR1 PGR
41 breast scirrhous carcinoma 10.3 ERBB2 ESR1 PGR
42 apocrine adenocarcinoma 10.3 ERBB2 ESR1 PGR
43 breast adenoid cystic carcinoma 10.3 ERBB2 ESR1 PGR
44 luminal breast carcinoma 10.3 ERBB2 ESR1 PGR
45 uterine corpus cancer 10.3 ERBB2 ESR1 PGR
46 inflammatory breast carcinoma 10.3 ERBB2 ESR1 PGR
47 bilateral breast cancer 10.3 ERBB2 ESR1 PGR
48 tubular adenocarcinoma 10.3 ERBB2 ESR1 PGR
49 endometrial disease 10.3 CYP19A1 ESR1
50 triple-receptor negative breast cancer 10.3 ERBB2 ESR1 PGR

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to Breast Fibroadenoma

Symptoms & Phenotypes for Breast Fibroadenoma

MGI Mouse Phenotypes related to Breast Fibroadenoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 PGR ESR1 RASSF1 KRT8 MED12 CYP19A1
2 digestive/alimentary MP:0005381 9.91 ESR1 RASSF1 KRT14 KRT8 CYP19A1 NGFR
3 endocrine/exocrine gland MP:0005379 9.87 PGR ESR1 RASSF1 KRT14 CYP19A1 NME1
4 integument MP:0010771 9.86 KRT14 MME CYP19A1 NGFR ERBB2 NME1
5 liver/biliary system MP:0005370 9.7 ESR1 RASSF1 KRT8 MME CYP19A1 NGFR
6 neoplasm MP:0002006 9.43 ESR1 RASSF1 KRT14 ERBB2 NME1 PGR
7 normal MP:0002873 9.17 PGR ESR1 RASSF1 MED12 CYP19A1 NGFR

Drugs & Therapeutics for Breast Fibroadenoma

Drugs for Breast Fibroadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 4 10540-29-1 2733526
2 Analgesics Phase 4
3 Analgesics, Non-Narcotic Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Antimetabolites Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Antirheumatic Agents Phase 4
9 Bone Density Conservation Agents Phase 4
10 Dermatologic Agents Phase 4
11 Efamol Phase 4
12 Estrogen Antagonists Phase 4
13 Estrogen Receptor Modulators Phase 4
14 Estrogens Phase 4
15 Hormone Antagonists Phase 4
16 Hormones Phase 4
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18 Hypolipidemic Agents Phase 4
19 Lipid Regulating Agents Phase 4
20 Peripheral Nervous System Agents Phase 4
21 Selective Estrogen Receptor Modulators Phase 4
22 Evening Primrose Nutraceutical Phase 4
23 Antibodies
24 Autoantibodies
25 Immunoglobulins
26 Pharmaceutical Solutions

Interventional clinical trials:

(show all 18)

# Name Status NCT ID Phase Drugs
1 Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer Completed NCT00999921 Phase 4 Tamoxifen;Evening Primrose Oil
2 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Completed NCT02011919 Phase 2, Phase 3
3 Feasibility Study Assessing the Treatment of Fibroadenomata With a Circumferential Sonication Treatment With HIFU Active, not recruiting NCT02139683 Phase 3
4 MR Guided Focused Ultrasound Surgery in the Treatment of Breast Fibroadenomas Terminated NCT00147108 Phase 3
5 Synthetic Aperture Radar Detection of Breast Tumours Unknown status NCT02493595
6 Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood Test Unknown status NCT02066025
7 High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma Completed NCT01422629
8 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Completed NCT03022695
9 ICE-SENSEā„¢ Cryotherapy for Breast Fibroadenoma Trial Completed NCT00910312
10 Optical Tomography With Ultrasound Guidance Completed NCT00908609
11 Treatment of Breast Fibroadenoma Targeted Tissue With HIFU Recruiting NCT03044054
12 Treatment of Breast Fibroadenoma With FastScan HIFU Recruiting NCT02488655
13 American Breast Laser Ablation Therapy Evaluation Recruiting NCT00807924
14 Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 Lesions Recruiting NCT02638935
15 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound Active, not recruiting NCT02078011
16 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Active, not recruiting NCT01331954
17 Multimode Laser Optoacoustic Ultrasonic Tomography System for Breast Cancer Care - LOUIS-3D Breast Study Active, not recruiting NCT01755130
18 London Investigation Into diElectric Scanning of Lesions Not yet recruiting NCT03302819

Search NIH Clinical Center for Breast Fibroadenoma

Cochrane evidence based reviews: fibroadenoma

Genetic Tests for Breast Fibroadenoma

Genetic tests related to Breast Fibroadenoma:

# Genetic test Affiliating Genes
1 Fibroadenoma of the Breast 28

Anatomical Context for Breast Fibroadenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Breast Fibroadenoma:

18
Breast

MalaCards organs/tissues related to Breast Fibroadenoma:

38
Breast, Testes, Bone, Lung

Publications for Breast Fibroadenoma

Articles related to Breast Fibroadenoma:

(show top 50) (show all 65)
# Title Authors Year
1
Advantages of the modified double ring areolar incision over the traditional areolar incision in multicentric breast fibroadenoma surgery. ( 28574223 )
2017
2
Minimally Invasive Breast Fibroadenoma Excision Using an Ultrasound-Guided Vacuum-Assisted Biopsy Device. ( 28331240 )
2017
3
Breast fibroadenoma with pseudoangiomatous (PASH-like) stroma. ( 28777747 )
2017
4
Primary Infarction of Breast Fibroadenoma in the Absence of Pregnancy or Lactation. ( 27670396 )
2017
5
Breast Fibroadenoma With Increased Activity on 68Ga DOTATATE PET/CT. ( 27879489 )
2017
6
Long-term efficacy of ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma. ( 28331611 )
2017
7
An Evaluation of Ultrasound Features of Breast Fibroadenoma. ( 29285483 )
2017
8
Invasive Ductal Carcinoma Displayed "Basal-Like" Feature Arising within a Breast Fibroadenoma. ( 27870335 )
2016
9
Multimodality approach in the diagnosis and management of bilateral giant juvenile breast fibroadenoma. ( 27758851 )
2016
10
Evaluation of the safety and efficacy of percutaneous radiofrequency ablation for treating multiple breast fibroadenoma. ( 28230006 )
2016
11
Ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma-a multicenter experience. ( 25635224 )
2015
12
High resolution compression elastography and color doppler sonography in characterization of breast fibroadenoma. ( 25227197 )
2014
13
Ultrasound-guided cryoablation of breast fibroadenoma: a pilot trial. ( 25408274 )
2014
14
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. ( 25038752 )
2014
15
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. ( 24089229 )
2013
16
Lobular intraepithelial neoplasia arising within breast fibroadenoma. ( 23849288 )
2013
17
Fine-needle aspiration of gray zone lesions of the breast: fibroadenoma versus ductal carcinoma. ( 22936545 )
2013
18
Transaxillary approach with use of traction suture for excision of breast fibroadenoma: a new technique and its results. ( 22604577 )
2012
19
Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. ( 21192183 )
2011
20
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. ( 22011321 )
2011
21
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. ( 21917252 )
2011
22
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue. ( 22249796 )
2011
23
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. ( 22121516 )
2011
24
Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. ( 21733035 )
2011
25
A clinical study on the resection of breast fibroadenoma using two types of incision. ( 22108740 )
2011
26
Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. ( 21875284 )
2011
27
Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. ( 24376952 )
2010
28
Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women. ( 21039041 )
2010
29
Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. ( 19897676 )
2010
30
Ectopic breast fibroadenoma of the vulva. ( 19622961 )
2009
31
Recurrence of giant juvenile breast fibroadenoma in a girl with Turner's syndrome. ( 19492586 )
2009
32
Herb-related aneuploidy in breast fibroadenoma. ( 21686556 )
2009
33
A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. ( 19211906 )
2009
34
Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. ( 18090908 )
2008
35
Invasive mucinous carcinoma arising within breast fibroadenoma. ( 18841829 )
2008
36
Breast fibroadenoma in female adolescents. ( 17206308 )
2007
37
Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. ( 18094894 )
2007
38
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. ( 16961651 )
2006
39
Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. ( 16297109 )
2005
40
Malignant transformation of a breast fibroadenoma to cystosarcoma phyllodes: case report and review of the literature. ( 15943412 )
2005
41
Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. ( 16405127 )
2005
42
p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. ( 15578730 )
2005
43
Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. ( 15450823 )
2004
44
Breast fibroadenoma in teenage females. ( 14768798 )
2003
45
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. ( 15200048 )
2003
46
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. ( 11271786 )
2001
47
Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. ( 9885614 )
1999
48
Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells. ( 10349403 )
1999
49
Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. ( 10432878 )
1999
50
Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. ( 9278103 )
1997

Variations for Breast Fibroadenoma

Expression for Breast Fibroadenoma

Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for Breast Fibroadenoma

Pathways related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.17 ERBB2 ESR1 PGR
2 9.23 CYP19A1 ESR1

GO Terms for Breast Fibroadenoma

Cellular components related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.7 ERBB2 ESR1 HMGA2 KRT14 KRT15 KRT8
2 intermediate filament GO:0005882 8.92 KRT14 KRT15 KRT8 NME1

Biological processes related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.54 ESR1 MED12 PGR
2 intracellular steroid hormone receptor signaling pathway GO:0030518 9.32 ESR1 MED12
3 androgen metabolic process GO:0008209 9.26 CYP19A1 ESR1
4 uterus development GO:0060065 9.16 CYP19A1 ESR1
5 cornification GO:0070268 9.13 KRT14 KRT15 KRT8
6 mammary gland development GO:0030879 8.8 CYP19A1 NME1 PGR

Molecular functions related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.96 ESR1 PGR
2 enzyme binding GO:0019899 8.92 ESR1 HMGA2 NME1 PGR

Sources for Breast Fibroadenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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