MCID: BRS053
MIFTS: 51

Breast Fibroadenoma malady

Summaries for Breast Fibroadenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Fibroadenomas of the breast are lumps composed of fibrous and glandular tissue. Because breast cancer... more...

MalaCards: Breast Fibroadenoma, also known as fibroadenoma, is related to breast cancer and adenoma. An important gene associated with Breast Fibroadenoma is HIF1A (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)), and among its related pathways are Nanog in Mammalian ESC Pluripotency and Angiogenesis. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and thyroid, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Breast Fibroadenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

breast fibroadenoma 8 10 44
fibroadenoma 8 44 60
juvenile fibroadenoma of breast 8 60
fibroadenoma of breast 8 60
complex fibroadenoma of the breast 8
fibroadenoma, no icd-o subtype 8
complex fibroadenoma of breast 8
juvenile fibroadenoma 8
cellular fibroadenoma 8
fibroadenoma nos 8


Related Diseases for Breast Fibroadenoma

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17GeneCards, 18GeneDecks
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Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.3VIM, PRLR, HIF1A, CYP19A1, FGF1, PGR
2adenoma30.1PRL, PRLR, FGFR4, FGF1
3ductal carcinoma in situ30.1ESR1, ERBB2, PGR
4myoma30.1CYP19A1, PGR, ESR1
5li-fraumeni syndrome30.0PRLR, CYP19A1, PGR, ERBB2, ESR1
6angiosarcoma29.8VIM
7gynecomastia29.8PRL, CYP19A1, PGR, ESR1
8breast giant fibroadenoma10.3
9multiple fibroadenomas of the breast10.3
10breast malignant phyllodes tumor10.2
11breast pericanalicular fibroadenoma10.1
12chickenpox10.1
13in situ carcinoma10.1
14neurofibromatosis10.1
15androgen insensitivity syndrome10.1
16granular cell tumor10.1
17breast granular cell tumor10.1
18giant cell tumor10.1
19transsexualism10.1
20beckwith-wiedemann syndrome10.1
21breast lymphoma10.1
22lobular neoplasia10.1
23breast mucinous carcinoma10.1
24hodgkin's lymphoma10.1
25medulloblastoma10.1
26breast intracanalicular fibroadenoma10.0
27breast fibroadenosis10.0
28obesity10.0HIF1A
29arthritis10.0FGF1
30tongue cancer10.0PRLR
31rheumatoid arthritis10.0PRLR
32alzheimer's disease10.0FGF1
33leydig cell tumor10.0CYP19A1
34osteoarthritis10.0FGF1
35lung cancer10.0ERBB2
36neuroendocrine tumor10.0PRL
37uterine carcinosarcoma10.0ERBB2
38craniopharyngioma10.0PRL
39aromatase deficiency10.0CYP19A1
40pheochromocytoma10.0FGF1, HIF1A
41sertoli-leydig cell tumor10.0PGR
42cervical cancer10.0HIF1A
43malignant glioma10.0HIF1A
44cushing's syndrome10.0PRL
45gastrointestinal stromal tumor10.0VIM
46chordoma10.0VIM
47hyperprolactinemia10.0PRLR, PRL
48rhabdomyosarcoma10.0VIM
49schizophrenia10.0PRL
50hypogonadism, hypergonadotropic10.0CYP19A1, PRL

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to breast fibroadenoma

Clinical Features for Breast Fibroadenoma

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Drugs & Therapeutics for Breast Fibroadenoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Breast Fibroadenoma

Drug clinical trials:

Search ClinicalTrials for Breast Fibroadenoma

Search NIH Clinical Center for Breast Fibroadenoma

Search CenterWatch for Breast Fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Anatomical Context for Breast Fibroadenoma

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32MalaCards
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MalaCards organs/tissues related to Breast Fibroadenoma:

32
Breast, Lung, Thyroid, Prostate

Animal Models for Breast Fibroadenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Breast Fibroadenoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.3PRLR
2MP:001077110.1PRLR, HIF1A
3MP:00053899.6PRL, ERBB2, PRLR
4MP:00053699.2CYP19A1, ESR1, HIF1A
5MP:00053768.3FGFR4, FGF1, PRLR, PGR, ESR1, PRL
6MP:00053908.1ESR1, ERBB2, PGR, CYP19A1, HIF1A, PRLR
7MP:00020068.0PGR, PRLR, PRL, HIF1A, FGFR4, ESR1
8MP:00053807.6ESR1, ERBB2, PGR, HIF1A, PRLR, VIM
9MP:00036317.3ESR1, HIF1A, PRLR, FGF1, VIM, PRL
10MP:00053867.2ESR1, ERBB2, PGR, CYP19A1, HIF1A, PRLR
11MP:00053847.0HIF1A, PRLR, ERBB2, ESR1, VIM, PGR

Publications for Breast Fibroadenoma

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50PubMed
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Articles related to Breast Fibroadenoma:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)
2013
2
Bilateral axillary masses mimicking as accessory breast with multiple fibroadenoma and bilateral gigantomastia in HIV-positive patient. (23813993)
2013
3
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
4
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. (22011321)
2011
5
Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. (21733035)
2011
6
Human sodium iodide symporter (hNIS) in fibroadenoma breast--a immunohistochemical study. (21428212)
2011
7
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)
2011
8
Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. (21192183)
2011
9
Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. (21875284)
2011
10
Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. (24376952)
2010
11
Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (19897676)
2010
12
Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women. (21039041)
2010
13
A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. (19211906)
2009
14
A rare coexistence of concurrent breast hemangioma with fibroadenoma: a case report. (19829893)
2009
15
Progesterone receptors A and B and estrogen receptor alpha expression in normal breast tissue and fibroadenomas. (19367380)
2009
16
Herb-related aneuploidy in breast fibroadenoma. (21686556)
2009
17
Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)
2008
18
RHEB expression in fibroadenomas of the breast. (18324915)
2008
19
Invasive mucinous carcinoma arising within breast fibroadenoma. (18841829)
2008
20
Morphologic changes in fibroadenoma of breast due to chickenpox: a case report with suspicious cytology in fine needle aspiration smears. (18540301)
2008
21
Breast fibroadenoma in female adolescents. (17206308)
2007
22
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. (16961651)
2006
23
Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. (16297109)
2005
24
Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. (16405127)
2005
25
Estrogen receptor-alpha, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast: association with nodule size, hormonal and reproductive features. (15763593)
2005
26
p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. (15578730)
2005
27
Association of viral factors with non-familial breast cancer in Taiwan by comparison with non-cancerous, fibroadenoma, and thyroid tumor tissues. (15602723)
2005
28
Augmented release of matrix metalloproteinase-9 by PKC activation in organotypic cultures of human breast cancer and adjacent normal breast tissue and fibroadenoma. (15481789)
2004
29
Metaphase and interphase cytogenetics in fibroadenomas of the breast. (15646810)
2004
30
Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women. (15241822)
2004
31
Expression of CD34 and bcl-2 in phyllodes tumours, fibroadenomas and spindle cell lesions of the breast. (11135048)
2001
32
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)
2001
33
Platelet-derived growth factor expression in phyllodes tumors and fibroadenomas of the breast. (11070114)
2000
34
Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. (10432878)
1999
35
Alteration of hMSH2 and DNA polymerase beta genes in breast carcinomas and fibroadenomas. (10362525)
1999
36
Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. (9885614)
1999
37
Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. (9278103)
1997
38
Elevated levels of prostate-specific antigen in serum of women with fibroadenomas and breast cysts. (9106652)
1997
39
Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)
1997
40
Variation of bcl-2 expression in breast ducts and lobules in relation to plasma progesterone levels: overexpression and absence of variation in fibroadenomas. (9390034)
1997
41
Breast fibroadenoma with atypical features: a case report. (8629423)
1996
42
High expression of the EGFR in fibroadenomas compared to breast carcinomas. (7847801)
1994
43
Expression of beta 1 integrins in non-neoplastic mammary epithelium, fibroadenoma and carcinoma of the breast. (8493776)
1993
44
Aspiration cytology of breast fibroadenoma with atypia. (1606889)
1992
45
Medulloblastoma metastasizing to a breast fibroadenoma: a case report. (2021436)
1991
46
Possibilities of the conventional and interventional sonography in diagnosis of breast fibroadenoma. (1841055)
1991
47
Morphometry of the breast fibroadenoma. (3562341)
1986
48
Management of breast fibroadenoma in women under 25 years of age. (3730963)
1986
49
A radiodiagnostic study of breast fibroadenoma. (2949499)
1985
50
The myoepithelium in human breast fibroadenoma. (4452932)
1974

Genetic Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Fibroadenoma

Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

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Sources:
51QIAGEN, 4Cell Signaling Technology, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7FGFR4, VIM
29.6FGF1, FGFR4, HIF1A
3
Hide members
9.5ESR1, CYP19A1
4
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9.5ERBB2, FGF1, FGFR4
59.5FGF1, FGFR4, ERBB2
69.4PRLR, PRL, ERBB2
79.4PRLR, CYP19A1, PGR
8
Hide members
9.3PRL, PGR, PRLR
9
Development Ligand-dependent activation of the ESR1/AP-1 pathway
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9.3HIF1A, ESR1, PRLR
109.2FGF1, FGFR4, PRL, PRLR
118.9ESR1, ERBB2, FGF1, HIF1A
128.9PRL, HIF1A, FGFR4, FGF1, ERBB2
13
Hide members
8.8FGFR4, PRL, PRLR, FGF1, ERBB2
14
Development Prolactin receptor signaling
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8.7ERBB2, PRLR, PRL, ESR1
15
Hide members
8.1ERBB2, FGF1, FGFR4, HIF1A, ESR1, VIM
16
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7.7PRL, PGR, ESR1, ERBB2, FGF1, FGFR4
17
Hide members
7.5PRLR, HIF1A, FGFR4, FGF1, PGR, ERBB2

Compounds for genes affiliated with Breast Fibroadenoma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6ARSH
2dexamethasone44 49 28 1113.0PRLR, HIF1A, FGF1
3idoxifene449.4CYP19A1, PGR, ESR1
45fluorouracil449.4PGR, HIF1A, ERBB2
5fadrozole449.3CYP19A1, ERBB2, ESR1
6danazol44 11 2411.2ESR1, ARSH, PGR, CYP19A1
7tibolone449.1ARSH, ESR1, PGR, CYP19A1
8gnrh449.1CYP19A1, ERBB2, ARSH, PRLR, PGR
9estradiol benzoate449.1ESR1, PGR, CYP19A1, PRL
10leuprolide acetate449.1PRL, ESR1, PGR, CYP19A1
11megestrol acetate449.0CYP19A1, ESR1, ERBB2, PGR
12clomiphene citrate449.0PGR, CYP19A1, PRL, ESR1
13steroidal449.0PGR, ESR1, ARSH, CYP19A1
14anastrozole44 1110.0ESR1, ERBB2, PGR, CYP19A1
15exemestane49 44 59 1112.0CYP19A1, PGR, ERBB2, ESR1
16lapatinib44 49 1111.0ESR1, PGR, CYP19A1, ERBB2
17levonorgestrel44 59 28 1112.0ESR1, PGR, CYP19A1, PRL
18fulvestrant44 49 28 1112.0CYP19A1, PGR, ESR1, ERBB2
19taxane449.0ERBB2, PGR, CYP19A1, ESR1
20flutamide44 59 1111.0PRL, ESR1, PGR, CYP19A1
21bisphenol a449.0PGR, ARSH, HIF1A, CYP19A1, ESR1
22letrozole44 49 59 1112.0ESR1, CYP19A1, ERBB2, PGR
23progestins448.9ESR1, CYP19A1, PGR, PRLR, ARSH
2417beta-hydroxysteroid448.9PGR, CYP19A1, ESR1, ARSH
25estrone sulfate44 249.8PGR, ARSH, PRL, CYP19A1, ESR1
26hydrocortisone44 2 59 1111.8FGF1, ERBB2, CYP19A1, PRL, VIM
27trastuzumab44 49 1110.8HIF1A, CYP19A1, PGR, ERBB2, ESR1
28geldanamycin44 49 59 1111.8ESR1, ERBB2, PGR, FGF1, HIF1A
29nandrolone44 249.8ESR1, CYP19A1, PGR
30estrone44 28 11 2411.7PRL, CYP19A1, PGR, ESR1, ARSH
31toremifene44 119.7ESR1, ERBB2, PGR, CYP19A1, PRL
32n-(4-hydroxyphenyl)retinamide448.7CYP19A1, ESR1, ERBB2, VIM
33paclitaxel44 49 1110.7CYP19A1, PGR, ERBB2, ESR1, HIF1A
34docetaxel44 49 59 1111.6CYP19A1, ERBB2, HIF1A, PGR, ESR1
35raloxifene44 28 49 1111.5ERBB2, CYP19A1, PGR, ESR1
36cyclophosphamide44 49 1110.5ERBB2, HIF1A, PGR, CYP19A1, ESR1
37steroid448.3ARSH, PRLR, PRL, CYP19A1, ESR1, ERBB2
384-hydroxytamoxifen448.3ESR1, VIM, ARSH, CYP19A1, PGR, ERBB2
39methotrexate44 49 1110.2ESR1, ERBB2, PGR, CYP19A1, HIF1A, VIM
40arginine448.1CYP19A1, FGFR4, ERBB2, HIF1A, PRL, FGF1
41dihydrotestosterone44 28 11 2411.1PGR, CYP19A1, HIF1A, PRL, VIM, ESR1
42doxorubicin44 49 1110.1PGR, ERBB2, CYP19A1, VIM, ESR1, HIF1A
43estradiol44 11 2410.0PRLR, PRL, ARSH, VIM, PGR, CYP19A1
44paraffin447.7PRLR, ESR1, ERBB2, PGR, FGF1, FGFR4
45genistein44 28 59 2 11 2412.7PGR, ERBB2, ESR1, FGF1, HIF1A, PRLR
46vegf447.6HIF1A, FGF1, FGFR4, ERBB2, ESR1, VIM
47progestin447.6PGR, PRL, PRLR, CYP19A1, ERBB2, ESR1
48progesterone44 59 28 11 2411.6VIM, PRLR, CYP19A1, PRL, PGR, ERBB2
49tamoxifen44 49 28 1110.1ESR1, ERBB2, PGR, FGF1, CYP19A1, HIF1A
50testosterone44 59 11 2410.1ERBB2, CYP19A1, PRLR, PRL, ARSH, ESR1

GO Terms for genes affiliated with Breast Fibroadenoma

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Sources:
16Gene Ontology
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Biological processes related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1organ inductionGO:00175910.1FGFR4, FGF1
2positive regulation of nitric-oxide synthase activityGO:0510009.8ESR1, HIF1A
3JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.8PRLR, PRL
4lactationGO:0075959.8HIF1A, PRLR, PRL
5androgen metabolic processGO:0082099.7CYP19A1, ESR1
6positive regulation of epithelial cell proliferationGO:0506799.6ERBB2, FGF1, PRL
7phosphatidylinositol-mediated signalingGO:0480159.6FGF1, FGFR4, ERBB2
8steroid biosynthetic processGO:0066949.5PRLR, CYP19A1
9fibroblast growth factor receptor signaling pathwayGO:0085439.4FGFR4, FGF1, ERBB2
10cell surface receptor signaling pathwayGO:0071669.4PRL, ERBB2, PRLR
11signal transductionGO:0071658.5ESR1, ERBB2, HIF1A, FGF1, PGR

Molecular functions related to Breast Fibroadenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein C-terminus bindingGO:0080228.7ERBB2, SYNJ2BP, VIM

Products for genes affiliated with Breast Fibroadenoma

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Sources for Breast Fibroadenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet