MCID: BRS053
MIFTS: 44

Breast Fibroadenoma malady

Categories: Genetic diseases, Cancer diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Breast Fibroadenoma

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Aliases & Descriptions for Breast Fibroadenoma:

Name: Breast Fibroadenoma 11 13 48
Fibroadenoma 11 48 37 66
Fibroadenoma of Breast 11 25 66
Juvenile Fibroadenoma of Breast 11 66
 
Complex Fibroadenoma of Breast 11
Juvenile Fibroadenoma 11
Cellular Fibroadenoma 11

Classifications:



Summaries for Breast Fibroadenoma

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Wikipedia:69 Fibroadenomas of the breast are benign tumors characterized by an admixture of stromal and epithelial... more...

MalaCards based summary: Breast Fibroadenoma, also known as fibroadenoma, is related to breast giant fibroadenoma and breast pericanalicular fibroadenoma. An important gene associated with Breast Fibroadenoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways are Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics and Thyroid hormone signaling pathway. Affiliated tissues include breast, breast and testes, and related mouse phenotypes are muscle and digestive/alimentary.

Disease Ontology:11 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

Related Diseases for Breast Fibroadenoma

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Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1breast giant fibroadenoma11.2
2breast pericanalicular fibroadenoma11.1
3ossifying fibromyxoid tumor10.8ERBB2, PGR
4eyelid disease10.7ERBB2, ESR1
5cutaneous mucoepidermoid carcinoma10.7ERBB2, PGR
6her2-receptor negative breast cancer10.7ERBB2, PGR
7extragonadal nonseminomatous germ cell tumor10.7ERBB2, ESR1
8vulvar angiokeratoma10.7ESR1, PGR
9central nervous system organ benign neoplasm10.7ESR1, PGR
10fallopian tube benign neoplasm10.7ESR1, PGR
11appendix leiomyoma10.7ESR1, PGR
12vaginal adenosarcoma10.7ERBB2, PGR
13mixed cell adenoma10.7ESR1, PGR
14mollaret meningitis10.7CYP19A1, PGR
15deafness, autosomal dominant 8/1210.7ESR1, PGR
16dental enamel hypoplasia10.7ESR1, PGR
17perinatal intestinal perforation10.6ESR1, PGR
18malignant secondary hypertension10.6CYP19A1, PGR
19focal chorioretinitis10.6ERBB2, PGR
20bartholin's gland adenoid cystic carcinoma10.6ESR1, PGR
21retinitis10.6ERBB2, PGR
22riedel's fibrosing thyroiditis10.6CYP19A1, ESR1
23asthma susceptibility 510.6ESR1, PGR
24gallbladder squamous cell carcinoma10.6ESR1, PGR
25amyloid tumor10.6ESR1, PGR
26extracranial neuroblastoma10.6ESR1, PGR
27infiltrative basal cell carcinoma10.6ESR1, PGR
28fallopian tube germ cell cancer10.6ESR1, PGR
29apocrine adenocarcinoma10.6ERBB2, PGR
30manouvrier syndrome10.6MED12, TP53
31cystinosis, nephropathic10.5ERBB2, TP53
32breast malignant phyllodes tumor10.5ERBB2, ESR1
33subacute thyroiditis10.5CD34, PGR
34gelatinous ascites10.5ERBB2, ESR1, PGR
35pilar sheath acanthoma10.5ESR1, PGR
36cervical serous adenocarcinoma10.5ERBB2, TP53
37trigeminal nerve disease10.5ERBB2, ESR1, PGR
38glottis verrucous carcinoma10.5ERBB2, ESR1, PGR
39bladder colonic type adenocarcinoma10.5ERBB2, ESR1, PGR
40adenocarcinoma in situ10.5ERBB2, ESR1, PGR
41mixed cell type kidney wilms' tumor10.5PGR, TP53
42bladder clear cell adenocarcinoma10.5ESR1, PGR
43anomalous left coronary artery from the pulmonary artery10.5ERBB2, ESR1, PGR
44pleomorphic carcinoma10.5ERBB2, ESR1, PGR
45immune system cancer10.5ERBB2, ESR1, PGR
46papillary thymic adenocarcinoma10.5ERBB2, ESR1, PGR
47skin epithelioid hemangioma10.5CD34, PGR
48breast papillomatosis10.5CD34, ESR1
49hilar lung neoplasm10.5CD34, PGR
50thoracic benign neoplasm10.5ESR1, MED12, PGR

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to breast fibroadenoma

Symptoms for Breast Fibroadenoma

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Drugs & Therapeutics for Breast Fibroadenoma

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Drugs for Breast Fibroadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TamoxifenPhase 436810540-29-12733526
Synonyms:
(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene
(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(Para-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine
(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine (IUPAC)
(Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE
(Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
,citrate
1-P-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-Para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-.beta.-Dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
10540-29-1
1ya4
2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
54965-24-1 (citrate)
AC1MBZ3R
Apo-Tamox
Apo-tamox
BIDD:ER0008
BIDD:GT0009
BIDD:PXR0003
BPBio1_000278
BRD-K93754473-001-02-9
BRD-K93754473-048-05-3
BSPBio_000252
BSPBio_001150
BSPBio_001982
C07108
C26H29NO
CCRIS 3275
CHEBI:41774
CHEMBL83
CID2733526
Citofen
Crisafeno
D08559
DB00675
Diemon
EINECS 234-118-0
Gen-Tamoxifen
Gen-tamoxifen
HMS1362J11
HMS1792J11
HMS1990J11
HMS2090N08
HSDB 6782
ICI 47699
ICI-46,474
ICI-47699
IDI1_000258
IDI1_002170
Istubol
Kessar
L024126
LS-393
Lopac0_001203
MLS001332535
MLS001332536
MolPort-003-850-384
 
NCGC00024928-01
NCGC00024928-03
NCGC00024928-04
NCGC00024928-05
NCGC00024928-07
NCGC00024928-08
NCGC00024928-09
NCGC00024928-12
NSC727681
Noltam
Nolvadex
Nolvadex-D
Nourytam
Novaldex
Novo-Tamoxifen
Oncomox
PMS-Tamoxifen
Pms-Tamoxifen
Prestwick2_000146
Prestwick3_000146
QTL1_000079
Retaxim
SMR000059172
ST50511785
Spectrum5_001417
Spectrum5_002043
T5648_SIGMA
TAMOXIFEN (TAMOXIFEN CITRATE (54965-24-1))
TRANS FORM OF TAMOXIFEN
Tamizam
Tamofen
Tamone
Tamoplex (TN)
Tamoxasta
Tamoxen
Tamoxifen
Tamoxifen (INN)
Tamoxifen (TN)
Tamoxifen (Z)
Tamoxifen Citrate
Tamoxifen [INN:BAN]
Tamoxifen and its salts
Tamoxifene
Tamoxifene [INN-French]
Tamoxifeno
Tamoxifeno [INN-Spanish]
Tamoxifenum
Tamoxifenum [INN-Latin]
Tamoxifène
Tocris-0999
Tomaxithen
Trans-Tamoxifen
UNII-094ZI81Y45
UPCMLD-DP027
Valodex
Zemide
cMAP_000044
nchembio.140-comp7
nchembio.76-comp1
nchembio732-comp3
tamoxifen
trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
trans-Tamoxifen

Interventional clinical trials:

(show all 15)
idNameStatusNCT IDPhase
1Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast CancerCompletedNCT00999921Phase 4
2Feasibility Study Assessing the Treatment of Fibroadenomata With a Circumferential Sonication Treatment With HIFUActive, not recruitingNCT02139683Phase 3
3Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)Active, not recruitingNCT02011919Phase 2, Phase 3
4MR Guided Focused Ultrasound Surgery in the Treatment of Breast FibroadenomasTerminatedNCT00147108Phase 3
5Treatment of Breast Fibroadenoma With FastScan HIFURecruitingNCT02488655Phase 1
6High Intensity Focused Ultrasound (HIFU) to Treat Breast FibroadenomaCompletedNCT01422629
7ICE-SENSE™ Cryotherapy for Breast Fibroadenoma TrialCompletedNCT00910312
8Treatment of Breast Fibroadenoma With High Intensity Focused UltrasoundRecruitingNCT02078011
9American Breast Laser Ablation Therapy EvaluationRecruitingNCT00807924
10Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 LesionsRecruitingNCT02638935
11Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)Active, not recruitingNCT01331954
12LOUIS-3D Breast StudyActive, not recruitingNCT01755130
13Optical Tomography With Ultrasound GuidanceActive, not recruitingNCT00908609
14Synthetic Aperture Radar Detection of Breast TumoursEnrolling by invitationNCT02493595
15Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood TestNot yet recruitingNCT02066025

Search NIH Clinical Center for Breast Fibroadenoma


Cochrane evidence based reviews: fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Genetic tests related to Breast Fibroadenoma:

id Genetic test Affiliating Genes
1 Fibroadenoma of the Breast25

Anatomical Context for Breast Fibroadenoma

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MalaCards organs/tissues related to Breast Fibroadenoma:

34
Breast, Testes, Lung

FMA organs/tissues related to Breast Fibroadenoma:

17
Breast

Animal Models for Breast Fibroadenoma or affiliated genes

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MGI Mouse Phenotypes related to Breast Fibroadenoma:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7CYP19A1, ERBB2, ESR1, PGR, PTS, TP53
2MP:00053818.4CYP19A1, ERBB2, ESR1, PLVAP, PTS, TP53
3MP:00053718.4ERBB2, ESR1, MED12, PGR, PLVAP, TP53
4MP:00107717.9CD34, CYP19A1, ERBB2, ESR1, PGR, PLVAP
5MP:00020067.9CD34, ERBB2, ESR1, PGR, RASSF1, TP53
6MP:00028737.7CYP19A1, ERBB2, ESR1, MED12, PGR, RASSF1
7MP:00053796.9CYP19A1, ERBB2, ESR1, PGR, PLVAP, PTS
8MP:00053856.9CYP19A1, ERBB2, ESR1, MED12, PGR, PLVAP

Publications for Breast Fibroadenoma

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Articles related to Breast Fibroadenoma:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma-a multicenter experience. (25635224)
2015
2
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. (25038752)
2014
3
Ultrasound-guided cryoablation of breast fibroadenoma: a pilot trial. (25408274)
2014
4
Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)
2013
5
Fine-needle aspiration of gray zone lesions of the breast: fibroadenoma versus ductal carcinoma. (22936545)
2013
6
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
7
Transaxillary approach with use of traction suture for excision of breast fibroadenoma: a new technique and its results. (22604577)
2012
8
A clinical study on the resection of breast fibroadenoma using two types of incision. (22108740)
2011
9
Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. (21733035)
2011
10
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)
2011
11
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. (22011321)
2011
12
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue. (22249796)
2011
13
Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. (21192183)
2011
14
Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. (21875284)
2011
15
Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. (24376952)
2010
16
Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (19897676)
2010
17
Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women. (21039041)
2010
18
Recurrence of giant juvenile breast fibroadenoma in a girl with Turner's syndrome. (19492586)
2009
19
Ectopic breast fibroadenoma of the vulva. (19622961)
2009
20
Herb-related aneuploidy in breast fibroadenoma. (21686556)
2009
21
A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. (19211906)
2009
22
Invasive mucinous carcinoma arising within breast fibroadenoma. (18841829)
2008
23
Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)
2008
24
Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. (18094894)
2007
25
Breast fibroadenoma in female adolescents. (17206308)
2007
26
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. (16961651)
2006
27
p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. (15578730)
2005
28
Malignant transformation of a breast fibroadenoma to cystosarcoma phyllodes: case report and review of the literature. (15943412)
2005
29
Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. (16297109)
2005
30
Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. (16405127)
2005
31
Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. (15450823)
2004
32
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
33
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)
2001
34
Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. (10432878)
1999
35
Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. (9885614)
1999
36
Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells. (10349403)
1999
37
Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. (9278103)
1997
38
Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)
1997
39
Breast fibroadenoma with atypical features: a case report. (8629423)
1996
40
Infarction of breast fibroadenoma in a postmenopausal woman. (8044310)
1994
41
Aspiration cytology of breast fibroadenoma with atypia. (1606889)
1992
42
Possibilities of the conventional and interventional sonography in diagnosis of breast fibroadenoma. (1841055)
1991
43
Medulloblastoma metastasizing to a breast fibroadenoma: a case report. (2021436)
1991
44
Risk factors for breast fibroadenoma in young women. (2766721)
1989
45
Carcinoma in a breast fibroadenoma. (3473866)
1987
46
Morphometry of the breast fibroadenoma. (3562341)
1986
47
A radiodiagnostic study of breast fibroadenoma. (2949499)
1985
48
Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells. (6164351)
1980
49
Breast fibroadenoma and cardiac anomaly associated with EMG (Beckwith-Wiedemann) syndrome. (430311)
1979
50
The myoepithelium in human breast fibroadenoma. (4452932)
1974

Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

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Pathways related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9CYP19A1, ESR1
29.4ESR1, MED12, TP53
39.4CYP19A1, ESR1, TP53
48.9ERBB2, RASSF1, TP53

GO Terms for genes affiliated with Breast Fibroadenoma

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Biological processes related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intracellular steroid hormone receptor signaling pathwayGO:003051810.3ESR1, MED12
2transcription initiation from RNA polymerase II promoterGO:00063679.8ESR1, MED12, PGR
3androgen metabolic processGO:00082099.6CYP19A1, ESR1
4negative regulation of gene expressionGO:00106299.3CD34, ESR1, PGR

Molecular functions related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:00081348.9CD34, ESR1, MED12, TP53

Sources for Breast Fibroadenoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet