Breast Fibroadenoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Breast Fibroadenoma

Sources:
⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Fibroadenomas of the breast are lumps composed of fibrous and glandular tissue. Because breast cancer... more...

MalaCards: Breast Fibroadenoma, also known as fibroadenoma, is related to breast cancer and adenoma. An important gene associated with Breast Fibroadenoma is HIF1A (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)), and among its related pathways are Nanog in Mammalian ESC Pluripotency and Angiogenesis. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and thyroid, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Breast Fibroadenoma

Sources:
⁸Disease Ontology, ¹⁰DISEASES, ⁴⁴Novoseek, ⁶⁰UMLS, ⁵⁶SNOMED-CT, ³⁹NCIt
See all sources

Aliases & Descriptions:

breast fibroadenoma ⁸ ¹⁰ ⁴⁴

fibroadenoma ⁸ ⁴⁴ ⁶⁰

juvenile fibroadenoma of breast ⁸ ⁶⁰

fibroadenoma of breast ⁸ ⁶⁰

complex fibroadenoma of the breast ⁸

fibroadenoma, no icd-o subtype ⁸

complex fibroadenoma of breast ⁸

juvenile fibroadenoma ⁸

cellular fibroadenoma ⁸

fibroadenoma nos ⁸

External Ids:

Disease Ontology⁸ DOID:1618

SNOMED-CT⁵⁶ 269640007, 254845004, 189820007 189102001, 46212000, 254847007, 65877006, more

NCIt³⁹ C3744

UMLS⁶⁰ C0346158, C1333137, C0206650 C0178421, more

Related Diseases for Breast Fibroadenoma

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 134)

id	Related Disease	Score	Top Affiliating Genes
1	breast cancer	30.3	VIM, PRLR, HIF1A, CYP19A1, FGF1, PGR
2	adenoma	30.1	PRL, PRLR, FGFR4, FGF1
3	ductal carcinoma in situ	30.1	ESR1, ERBB2, PGR
4	myoma	30.1	CYP19A1, PGR, ESR1
5	li-fraumeni syndrome	30.0	PRLR, CYP19A1, PGR, ERBB2, ESR1
6	angiosarcoma	29.8	VIM
7	gynecomastia	29.8	PRL, CYP19A1, PGR, ESR1
8	breast giant fibroadenoma	10.3
9	multiple fibroadenomas of the breast	10.3
10	breast malignant phyllodes tumor	10.2
11	breast pericanalicular fibroadenoma	10.1
12	chickenpox	10.1
13	in situ carcinoma	10.1
14	neurofibromatosis	10.1
15	androgen insensitivity syndrome	10.1
16	granular cell tumor	10.1
17	breast granular cell tumor	10.1
18	giant cell tumor	10.1
19	transsexualism	10.1
20	beckwith-wiedemann syndrome	10.1
21	breast lymphoma	10.1
22	lobular neoplasia	10.1
23	breast mucinous carcinoma	10.1
24	hodgkin's lymphoma	10.1
25	medulloblastoma	10.1
26	breast intracanalicular fibroadenoma	10.0
27	breast fibroadenosis	10.0
28	obesity	10.0	HIF1A
29	arthritis	10.0	FGF1
30	tongue cancer	10.0	PRLR
31	rheumatoid arthritis	10.0	PRLR
32	alzheimer's disease	10.0	FGF1
33	leydig cell tumor	10.0	CYP19A1
34	osteoarthritis	10.0	FGF1
35	lung cancer	10.0	ERBB2
36	neuroendocrine tumor	10.0	PRL
37	uterine carcinosarcoma	10.0	ERBB2
38	craniopharyngioma	10.0	PRL
39	aromatase deficiency	10.0	CYP19A1
40	pheochromocytoma	10.0	FGF1, HIF1A
41	sertoli-leydig cell tumor	10.0	PGR
42	cervical cancer	10.0	HIF1A
43	malignant glioma	10.0	HIF1A
44	cushing's syndrome	10.0	PRL
45	gastrointestinal stromal tumor	10.0	VIM
46	chordoma	10.0	VIM
47	hyperprolactinemia	10.0	PRLR, PRL
48	rhabdomyosarcoma	10.0	VIM
49	schizophrenia	10.0	PRL
50	hypogonadism, hypergonadotropic	10.0	CYP19A1, PRL

Graphical network of the top 20 diseases related to Breast Fibroadenoma:

Clinical Features for Breast Fibroadenoma

Drugs & Therapeutics for Breast Fibroadenoma

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Breast Fibroadenoma

Drug clinical trials:

Search ClinicalTrials for Breast Fibroadenoma

Search NIH Clinical Center for Breast Fibroadenoma

Search CenterWatch for Breast Fibroadenoma

Genetic Tests for Breast Fibroadenoma

Anatomical Context for Breast Fibroadenoma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Breast Fibroadenoma:

³²

Breast, Lung, Thyroid, Prostate

Animal Models for Breast Fibroadenoma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Breast Fibroadenoma:

³⁶ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.3	PRLR
2	integument phenotype	MP:0010771	10.1	PRLR, HIF1A
3	reproductive system phenotype	MP:0005389	9.6	PRL, ERBB2, PRLR
4	muscle phenotype	MP:0005369	9.2	CYP19A1, ESR1, HIF1A
5	homeostasis/metabolism phenotype	MP:0005376	8.3	FGFR4, FGF1, PRLR, PGR, ESR1, PRL
6	skeleton phenotype	MP:0005390	8.1	ESR1, ERBB2, PGR, CYP19A1, HIF1A, PRLR
7	tumorigenesis	MP:0002006	8.0	PGR, PRLR, PRL, HIF1A, FGFR4, ESR1
8	embryogenesis phenotype	MP:0005380	7.6	ESR1, ERBB2, PGR, HIF1A, PRLR, VIM
9	nervous system phenotype	MP:0003631	7.3	ESR1, HIF1A, PRLR, FGF1, VIM, PRL
10	behavior/neurological phenotype	MP:0005386	7.2	ESR1, ERBB2, PGR, CYP19A1, HIF1A, PRLR
11	cellular phenotype	MP:0005384	7.0	HIF1A, PRLR, ERBB2, ESR1, VIM, PGR

Publications for Breast Fibroadenoma

Sources:
⁵⁰PubMed
See all sources

Articles related to Breast Fibroadenoma:

(show top 50) (show all 81)

id	Title	Authors	Year
1	Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)	Limite G.... Forestieri P.	2013
2	Bilateral axillary masses mimicking as accessory breast with multiple fibroadenoma and bilateral gigantomastia in HIV-positive patient. (23813993)	Singh S.... Kumar S.	2013
3	First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)	Pacchiarotti A.... Frati P.	2013
4	Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. (22011321)	Marzese D.M.... Vargas-Roig L.M.	2011
5	Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. (21733035)	Zhang J.... Liu H.	2011
6	Human sodium iodide symporter (hNIS) in fibroadenoma breast--a immunohistochemical study. (21428212)	Rai R.... Pal L.	2011
7	First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)	Pacchiarotti A.... Moscarini M.	2011
8	Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. (21192183)	Audisio T.... Ramallo R.	2011
9	Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. (21875284)	Bidgoli S.A.... Eftekhari T.	2011
10	Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. (24376952)	PoA8om K.... Murawa P.	2010
11	Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (19897676)	Courtillot C.... Touraine P.	2010
12	Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women. (21039041)	Looi L.M.... Rahman N.A.	2010
13	A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. (19211906)	Moralidis E.... Karakatsanis C.	2009
14	A rare coexistence of concurrent breast hemangioma with fibroadenoma: a case report. (19829893)	Kawatra V.... Khurana N.	2009
15	Progesterone receptors A and B and estrogen receptor alpha expression in normal breast tissue and fibroadenomas. (19367380)	Branchini G.... Brum I.S.	2009
16	Herb-related aneuploidy in breast fibroadenoma. (21686556)	Chang C.J.... Lui W.Y.	2009
17	Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)	Zubor P.... Danko J.	2008
18	RHEB expression in fibroadenomas of the breast. (18324915)	Eom M.... Park K.H.	2008
19	Invasive mucinous carcinoma arising within breast fibroadenoma. (18841829)	Charfi L.... Ben Romdhane K.	2008
20	Morphologic changes in fibroadenoma of breast due to chickenpox: a case report with suspicious cytology in fine needle aspiration smears. (18540301)	Das D.K.... Mirza K.	2008
21	Breast fibroadenoma in female adolescents. (17206308)	Tiryaki T.... Kibar A.E.	2007
22	FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. (16961651)	Kollur S.M.... el Hag I.A.	2006
23	Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. (16297109)	Yuen S.... Furukawa H.	2005
24	Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. (16405127)	Yavisheva T.M.... Savluchinskaya L.A.	2005
25	Estrogen receptor-alpha, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast: association with nodule size, hormonal and reproductive features. (15763593)	Cericatto R.... Spritzer P.M.	2005
26	p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. (15578730)	Di Vinci A.... Romani M.	2005
27	Association of viral factors with non-familial breast cancer in Taiwan by comparison with non-cancerous, fibroadenoma, and thyroid tumor tissues. (15602723)	Tsai J.H.... Yang C.C.	2005
28	Augmented release of matrix metalloproteinase-9 by PKC activation in organotypic cultures of human breast cancer and adjacent normal breast tissue and fibroadenoma. (15481789)	Wu T.T.... Liu J.Y.	2004
29	Metaphase and interphase cytogenetics in fibroadenomas of the breast. (15646810)	Rizou H.... Pandis N.	2004
30	Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women. (15241822)	Hefler L.A.... Koelbl H.	2004
31	Expression of CD34 and bcl-2 in phyllodes tumours, fibroadenomas and spindle cell lesions of the breast. (11135048)	Moore T.... Lee A.H.	2001
32	Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)	La Rosa S.... Capella C.	2001
33	Platelet-derived growth factor expression in phyllodes tumors and fibroadenomas of the breast. (11070114)	Feakins R.M.... Sheaff M.T.	2000
34	Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. (10432878)	LA^pez-Ferrer P.... Viguer J.M.	1999
35	Alteration of hMSH2 and DNA polymerase beta genes in breast carcinomas and fibroadenomas. (10362525)	Bhattacharyya N.... Banerjee S.	1999
36	Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. (9885614)	Weinstein D.... Degani H.	1999
37	Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. (9278103)	Szylberg T.... Kulig A.	1997
38	Elevated levels of prostate-specific antigen in serum of women with fibroadenomas and breast cysts. (9106652)	Borchert G.H.... Diamandis E.P.	1997
39	Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)	Pasqualini J.R.... Ruiz A.	1997
40	Variation of bcl-2 expression in breast ducts and lobules in relation to plasma progesterone levels: overexpression and absence of variation in fibroadenomas. (9390034)	FerriA"res G.... Escot C.	1997
41	Breast fibroadenoma with atypical features: a case report. (8629423)	Kordek R.... Kubiak R.	1996
42	High expression of the EGFR in fibroadenomas compared to breast carcinomas. (7847801)	Zelada-Hedman M.... NordenskjAPld M.	1994
43	Expression of beta 1 integrins in non-neoplastic mammary epithelium, fibroadenoma and carcinoma of the breast. (8493776)	Mechtersheimer G.... MAPller P.	1993
44	Aspiration cytology of breast fibroadenoma with atypia. (1606889)	Chen K.T.	1992
45	Medulloblastoma metastasizing to a breast fibroadenoma: a case report. (2021436)	Brydon H.L.... Carey M.P.	1991
46	Possibilities of the conventional and interventional sonography in diagnosis of breast fibroadenoma. (1841055)	Nedeva A.... Ivanov V.	1991
47	Morphometry of the breast fibroadenoma. (3562341)	Pesce C.... Colacino R.	1986
48	Management of breast fibroadenoma in women under 25 years of age. (3730963)	Kapoor V.K.... Sharma L.K.	1986
49	A radiodiagnostic study of breast fibroadenoma. (2949499)	Rocek V.... VojA!cek K.	1985
50	The myoepithelium in human breast fibroadenoma. (4452932)	Ahmed A.	1974

Genes related to Breast Fibroadenoma

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Breast Fibroadenoma:

(show all 13)

id	Symbol	Description	Score	Implication
1	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	20.77	GeneCards inferred : Disorders (show sections)
2	ARSH	arylsulfatase family, member H	19.19	GeneCards inferred : Publications, Disorders (show sections)
3	FGFR4	fibroblast growth factor receptor 4	17.65	GeneCards inferred : Publications, Disorders (show sections)
4	FGF1	fibroblast growth factor 1 (acidic)	16.11	GeneCards inferred : Publications, Disorders (show sections)
5	PRLR	prolactin receptor	14.58	GeneCards inferred : Publications, Disorders (show sections)
6	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	13.04	GeneCards inferred : Publications, Disorders (show sections)
7	PRL	prolactin	11.50	GeneCards inferred : Publications, Disorders (show sections)
8	ERBB2	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	9.96	GeneCards inferred : Publications, Disorders (show sections)
9	PGR	progesterone receptor	8.42	GeneCards inferred : Disorders (show sections)
10	VIM	vimentin	6.88	GeneCards inferred : Disorders (show sections)
11	ESR1	estrogen receptor 1	5.34	GeneCards inferred : Disorders (show sections)
12	SYNJ2BP	synaptojanin 2 binding protein	3.81	GeneCards inferred : Disorders (show sections)
13	NUCKS1	nuclear casein kinase and cyclin-dependent kinase substrate 1	2.27	GeneCards inferred : Disorders (show sections)

Products for genes related to Breast Fibroadenoma disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	13	13	13
2	LSBio	-	-	13

Genetic Variations for Breast Fibroadenoma

Expression for genes affiliated with Breast Fibroadenoma

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Breast Fibroadenoma

Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

Sources:
⁵¹QIAGEN, ⁴Cell Signaling Technology, ⁵³Reactome, ⁴⁹PharmGKB, ³⁷NCBI BioSystems Database, ¹²EMD Millipore, ²⁹KEGG
See all sources

Pathways related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 17)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Nanog in Mammalian ESC Pluripotency⁵¹ Hide members GSK3 Signaling⁵¹ eNOS Signaling⁵¹ 14-3-3 Induced Intracellular Signaling⁵¹	9.7	FGFR4, VIM
2	Angiogenesis⁴	9.6	FGF1, FGFR4, HIF1A
3	Estrogen biosynthesis⁵³ Hide members Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics⁴⁹ Aromatase Inhibitor Pathway (Multiple Tissues), Pharmacodynamics⁴⁹	9.5	ESR1, CYP19A1
4	Ca-dependent events⁵³ Hide members PLCG1 events in ERBB2 signaling⁵³ Phospholipase C-mediated cascade⁵³	9.5	ERBB2, FGF1, FGFR4
5	Tyrosine Kinases / Adaptors⁴	9.5	FGF1, FGFR4, ERBB2
6	ErbB4 signaling events³⁷	9.4	PRLR, PRL, ERBB2
7	Ovarian Infertility Genes³⁷	9.4	PRLR, CYP19A1, PGR
8	Prolactin receptor signaling⁵³ Hide members Nuclear signaling by ERBB4⁵³ Growth hormone receptor signaling⁵³	9.3	PRL, PGR, PRLR
9	Development Ligand-dependent activation of the ESR1/AP-1 pathway Hide members Transcription Ligand-dependent activation of the ESR1/SP pathway¹² Development Ligand-dependent activation of the ESR1/AP-1 pathway¹²	9.3	HIF1A, ESR1, PRLR
10	PI3K-Akt signaling pathway²⁹	9.2	FGF1, FGFR4, PRL, PRLR
11	Proteoglycans in cancer²⁹	8.9	ESR1, ERBB2, FGF1, HIF1A
12	Disease⁵³	8.9	PRL, HIF1A, FGFR4, FGF1, ERBB2
13	TGF-Beta Pathway⁵¹ Hide members JAK-STAT Pathway⁵¹ JNK Pathway⁵¹ SOCS Pathway⁵¹ Regulation of eIF4 and p70S6K⁵¹ MAPK Family Pathway⁵¹	8.8	FGFR4, PRL, PRLR, FGF1, ERBB2
14	Development Prolactin receptor signaling Hide members Prolactin signaling pathway²⁹ Leptin signaling pathway³⁷ Prolactin Signaling Pathway³⁷ Development Prolactin receptor signaling¹²	8.7	ERBB2, PRLR, PRL, ESR1
15	Rho Family GTPases⁵¹ Hide members ERK Signaling⁵¹ ILK Signaling⁵¹ Molecular Mechanisms of Cancer⁵¹ MAPK Signaling⁵¹	8.1	ERBB2, FGF1, FGFR4, HIF1A, ESR1, VIM
16	PIP3 activates AKT signaling⁵³ Hide members Signaling by ERBB4⁵³ PI-3K cascade⁵³ Signaling by SCF-KIT⁵³ PI3K events in ERBB2 signaling⁵³ PI3K events in ERBB4 signaling⁵³ GAB1 signalosome⁵³ PI3K/AKT Signaling in Cancer⁵³ Constitutive PI3K/AKT Signaling in Cancer⁵³ PI3K/AKT activation⁵³	7.7	PRL, PGR, ESR1, ERBB2, FGF1, FGFR4
17	Signaling by GPCR⁵³ Hide members Signal Transduction⁵³	7.5	PRLR, HIF1A, FGFR4, FGF1, PGR, ERBB2

Compounds for genes affiliated with Breast Fibroadenoma

Sources:
⁴⁴Novoseek, ⁴⁹PharmGKB, ²⁸IUPHAR, ¹¹DrugBank, ²⁴HMDB, ⁵⁹Tocris Bioscience, ²BitterDB
See all sources

Compounds related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show top 50) (show all 119)

id	Compound	Score	Top Affiliating Genes
1	estrogen⁴⁴	10.6	ARSH
2	dexamethasone⁴⁴ ⁴⁹ ²⁸ ¹¹	13.0	PRLR, HIF1A, FGF1
3	idoxifene⁴⁴	9.4	CYP19A1, PGR, ESR1
4	5fluorouracil⁴⁴	9.4	PGR, HIF1A, ERBB2
5	fadrozole⁴⁴	9.3	CYP19A1, ERBB2, ESR1
6	danazol⁴⁴ ¹¹ ²⁴	11.2	ESR1, ARSH, PGR, CYP19A1
7	tibolone⁴⁴	9.1	ARSH, ESR1, PGR, CYP19A1
8	gnrh⁴⁴	9.1	CYP19A1, ERBB2, ARSH, PRLR, PGR
9	estradiol benzoate⁴⁴	9.1	ESR1, PGR, CYP19A1, PRL
10	leuprolide acetate⁴⁴	9.1	PRL, ESR1, PGR, CYP19A1
11	megestrol acetate⁴⁴	9.0	CYP19A1, ESR1, ERBB2, PGR
12	clomiphene citrate⁴⁴	9.0	PGR, CYP19A1, PRL, ESR1
13	steroidal⁴⁴	9.0	PGR, ESR1, ARSH, CYP19A1
14	anastrozole⁴⁴ ¹¹	10.0	ESR1, ERBB2, PGR, CYP19A1
15	exemestane⁴⁹ ⁴⁴ ⁵⁹ ¹¹	12.0	CYP19A1, PGR, ERBB2, ESR1
16	lapatinib⁴⁴ ⁴⁹ ¹¹	11.0	ESR1, PGR, CYP19A1, ERBB2
17	levonorgestrel⁴⁴ ⁵⁹ ²⁸ ¹¹	12.0	ESR1, PGR, CYP19A1, PRL
18	fulvestrant⁴⁴ ⁴⁹ ²⁸ ¹¹	12.0	CYP19A1, PGR, ESR1, ERBB2
19	taxane⁴⁴	9.0	ERBB2, PGR, CYP19A1, ESR1
20	flutamide⁴⁴ ⁵⁹ ¹¹	11.0	PRL, ESR1, PGR, CYP19A1
21	bisphenol a⁴⁴	9.0	PGR, ARSH, HIF1A, CYP19A1, ESR1
22	letrozole⁴⁴ ⁴⁹ ⁵⁹ ¹¹	12.0	ESR1, CYP19A1, ERBB2, PGR
23	progestins⁴⁴	8.9	ESR1, CYP19A1, PGR, PRLR, ARSH
24	17beta-hydroxysteroid⁴⁴	8.9	PGR, CYP19A1, ESR1, ARSH
25	estrone sulfate⁴⁴ ²⁴	9.8	PGR, ARSH, PRL, CYP19A1, ESR1
26	hydrocortisone⁴⁴ ² ⁵⁹ ¹¹	11.8	FGF1, ERBB2, CYP19A1, PRL, VIM
27	trastuzumab⁴⁴ ⁴⁹ ¹¹	10.8	HIF1A, CYP19A1, PGR, ERBB2, ESR1
28	geldanamycin⁴⁴ ⁴⁹ ⁵⁹ ¹¹	11.8	ESR1, ERBB2, PGR, FGF1, HIF1A
29	nandrolone⁴⁴ ²⁴	9.8	ESR1, CYP19A1, PGR
30	estrone⁴⁴ ²⁸ ¹¹ ²⁴	11.7	PRL, CYP19A1, PGR, ESR1, ARSH
31	toremifene⁴⁴ ¹¹	9.7	ESR1, ERBB2, PGR, CYP19A1, PRL
32	n-(4-hydroxyphenyl)retinamide⁴⁴	8.7	CYP19A1, ESR1, ERBB2, VIM
33	paclitaxel⁴⁴ ⁴⁹ ¹¹	10.7	CYP19A1, PGR, ERBB2, ESR1, HIF1A
34	docetaxel⁴⁴ ⁴⁹ ⁵⁹ ¹¹	11.6	CYP19A1, ERBB2, HIF1A, PGR, ESR1
35	raloxifene⁴⁴ ²⁸ ⁴⁹ ¹¹	11.5	ERBB2, CYP19A1, PGR, ESR1
36	cyclophosphamide⁴⁴ ⁴⁹ ¹¹	10.5	ERBB2, HIF1A, PGR, CYP19A1, ESR1
37	steroid⁴⁴	8.3	ARSH, PRLR, PRL, CYP19A1, ESR1, ERBB2
38	4-hydroxytamoxifen⁴⁴	8.3	ESR1, VIM, ARSH, CYP19A1, PGR, ERBB2
39	methotrexate⁴⁴ ⁴⁹ ¹¹	10.2	ESR1, ERBB2, PGR, CYP19A1, HIF1A, VIM
40	arginine⁴⁴	8.1	CYP19A1, FGFR4, ERBB2, HIF1A, PRL, FGF1
41	dihydrotestosterone⁴⁴ ²⁸ ¹¹ ²⁴	11.1	PGR, CYP19A1, HIF1A, PRL, VIM, ESR1
42	doxorubicin⁴⁴ ⁴⁹ ¹¹	10.1	PGR, ERBB2, CYP19A1, VIM, ESR1, HIF1A
43	estradiol⁴⁴ ¹¹ ²⁴	10.0	PRLR, PRL, ARSH, VIM, PGR, CYP19A1
44	paraffin⁴⁴	7.7	PRLR, ESR1, ERBB2, PGR, FGF1, FGFR4
45	genistein⁴⁴ ²⁸ ⁵⁹ ² ¹¹ ²⁴	12.7	PGR, ERBB2, ESR1, FGF1, HIF1A, PRLR
46	vegf⁴⁴	7.6	HIF1A, FGF1, FGFR4, ERBB2, ESR1, VIM
47	progestin⁴⁴	7.6	PGR, PRL, PRLR, CYP19A1, ERBB2, ESR1
48	progesterone⁴⁴ ⁵⁹ ²⁸ ¹¹ ²⁴	11.6	VIM, PRLR, CYP19A1, PRL, PGR, ERBB2
49	tamoxifen⁴⁴ ⁴⁹ ²⁸ ¹¹	10.1	ESR1, ERBB2, PGR, FGF1, CYP19A1, HIF1A
50	testosterone⁴⁴ ⁵⁹ ¹¹ ²⁴	10.1	ERBB2, CYP19A1, PRLR, PRL, ARSH, ESR1

GO Terms for genes affiliated with Breast Fibroadenoma

Sources:
¹⁶Gene Ontology
See all sources

Biological processes related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	organ induction	GO:001759	10.1	FGFR4, FGF1
2	positive regulation of nitric-oxide synthase activity	GO:051000	9.8	ESR1, HIF1A
3	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	9.8	PRLR, PRL
4	lactation	GO:007595	9.8	HIF1A, PRLR, PRL
5	androgen metabolic process	GO:008209	9.7	CYP19A1, ESR1
6	positive regulation of epithelial cell proliferation	GO:050679	9.6	ERBB2, FGF1, PRL
7	phosphatidylinositol-mediated signaling	GO:048015	9.6	FGF1, FGFR4, ERBB2
8	steroid biosynthetic process	GO:006694	9.5	PRLR, CYP19A1
9	fibroblast growth factor receptor signaling pathway	GO:008543	9.4	FGFR4, FGF1, ERBB2
10	cell surface receptor signaling pathway	GO:007166	9.4	PRL, ERBB2, PRLR
11	signal transduction	GO:007165	8.5	ESR1, ERBB2, HIF1A, FGF1, PGR