MCID: BRS053
MIFTS: 46

Breast Fibroadenoma malady

Categories: Genetic diseases, Cancer diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Breast Fibroadenoma

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Aliases & Descriptions for Breast Fibroadenoma:

Name: Breast Fibroadenoma 11 50 13
Fibroadenoma 11 50 39 68
Fibroadenoma of Breast 11 27 68
Juvenile Fibroadenoma of Breast 11 68
 
Complex Fibroadenoma of Breast 11
Juvenile Fibroadenoma 11
Cellular Fibroadenoma 11

Classifications:



Summaries for Breast Fibroadenoma

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Wikipedia:71 Fibroadenomas of the breast are benign tumors characterized by an admixture of stromal and epithelial... more...

MalaCards based summary: Breast Fibroadenoma, also known as fibroadenoma, is related to breast giant fibroadenoma and multiple fibroadenomas of the breast. An important gene associated with Breast Fibroadenoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways are Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics and Signaling by ERBB4. Affiliated tissues include breast, breast and lung, and related mouse phenotypes are neoplasm and digestive/alimentary.

Disease Ontology:11 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

Related Diseases for Breast Fibroadenoma

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Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1breast giant fibroadenoma11.1
2multiple fibroadenomas of the breast11.0
3breast pericanalicular fibroadenoma11.0
4mouth disease10.3ERBB2, PGR
5pericardium leiomyoma10.3MED12, PGR
6mucoepidermoid thyroid carcinoma10.3ERBB2, PGR
7triple-receptor negative breast cancer10.3ERBB2, PGR
8renal infectious disease10.3ERBB2, KRT8
9skin sarcoma10.3ERBB2, PGR
10bartholin's gland benign neoplasm10.3ESR1, PGR
11cardiovascular organ benign neoplasm10.3ESR1, PGR
12appendix leiomyoma10.3ESR1, PGR
13bronchus adenoma10.3ESR1, PGR
14ovarian benign neoplasm10.3ESR1, PGR
15plexiform neurofibroma10.3ESR1, PGR
16hereditary breast ovarian cancer10.3ERBB2, ESR1
17paranasal sinus disease10.3ESR1, PGR
18deafness, autosomal recessive 2110.3ESR1, PGR
19atypical lipomatous tumor10.3ESR1, PGR
20congenital disorder of glycosylation, type ic10.2ESR1, PGR
21intestinal perforation10.2ESR1, PGR
22perlman syndrome10.2ESR1, PGR
23biemond syndrome10.2CYP19A1, PGR
24bladder adenocarcinoma10.2ESR1, PGR
25glioma10.2ERBB2, ESR1, PGR
26cervical lymphoepithelioma-like carcinoma10.2ERBB2, ESR1, PGR
27histiocytic and dendritic cell cancer10.2ERBB2, ESR1, PGR
28poliomyelitis10.2ERBB2, ESR1, PGR
29anal neuroendocrine tumor10.2ESR1, PGR
30central nervous system mature teratoma10.2ERBB2, ESR1, PGR
31postpartum depression10.2ERBB2, ESR1, PGR
32combined t cell and b cell immunodeficiency10.2ERBB2, ESR1, PGR
33anomalous left coronary artery from the pulmonary artery10.2ERBB2, ESR1, PGR
34polyembryoma of the ovary10.2ERBB2, ESR1, PGR
35fallopian tube carcinosarcoma10.2ERBB2, ESR1, PGR
36sclerosing hemangioma10.2ERBB2, ESR1, PGR
37osteogenesis imperfecta10.2CYP19A1, ESR1, PGR
38organ system benign neoplasm10.2ERBB2, ESR1, PGR
39his bundle tachycardia10.2ERBB2, ESR1, PGR
40lung squamous cell carcinoma10.2KRT15, KRT8
41her2-receptor positive breast cancer10.2ERBB2, ESR1, PGR
42acute thyroiditis10.2CYP19A1, ESR1, PGR
43perinatal jaundice due to hepatocellular damage10.2CYP19A1, ESR1, PGR
44congenital bile acid synthesis defect10.2ERBB2, ESR1, PGR
45epithelioid neurofibroma10.2ESR1, MED12, PGR
46esophagus sarcoma10.2CYP19A1, ESR1, PGR
47pyomyositis10.2ERBB2, ESR1, PGR
48metagonimiasis10.2ERBB2, ESR1, PGR
49pituitary stalk meningioma10.2ERBB2, ESR1, PGR
50prostatic adenoma10.2ERBB2, ESR1, PGR

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to breast fibroadenoma

Symptoms & Phenotypes for Breast Fibroadenoma

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MGI Mouse Phenotypes related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9ERBB2, ESR1, KRT14, NME1, PGR, RASSF1
2MP:00053818.7CYP19A1, ERBB2, ESR1, KRT14, KRT8, NGFR
3MP:00053798.7CYP19A1, ERBB2, ESR1, KRT14, NME1, PGR
4MP:00053858.7CYP19A1, ERBB2, ESR1, KRT8, MED12, NGFR
5MP:00028738.2CYP19A1, ERBB2, ESR1, MED12, NGFR, PGR
6MP:00053707.9CYP19A1, ESR1, KRT8, MME, NGFR, NME1
7MP:00107717.8CYP19A1, ERBB2, ESR1, KRT14, MME, NGFR

Drugs & Therapeutics for Breast Fibroadenoma

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Drugs for Breast Fibroadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TamoxifenapprovedPhase 439010540-29-12733526
Synonyms:
(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene
(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(Para-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine
(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine (IUPAC)
(Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE
(Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
,citrate
1-P-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-Para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-.beta.-Dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
10540-29-1
1ya4
2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
54965-24-1 (citrate)
AC1MBZ3R
Apo-Tamox
Apo-tamox
BIDD:ER0008
BIDD:GT0009
BIDD:PXR0003
BPBio1_000278
BRD-K93754473-001-02-9
BRD-K93754473-048-05-3
BSPBio_000252
BSPBio_001150
BSPBio_001982
C07108
C26H29NO
CCRIS 3275
CHEBI:41774
CHEMBL83
CID2733526
Citofen
Crisafeno
D08559
DB00675
Diemon
EINECS 234-118-0
Gen-Tamoxifen
Gen-tamoxifen
HMS1362J11
HMS1792J11
HMS1990J11
HMS2090N08
HSDB 6782
ICI 47699
ICI-46,474
ICI-47699
IDI1_000258
IDI1_002170
Istubol
Kessar
L024126
LS-393
Lopac0_001203
MLS001332535
MLS001332536
MolPort-003-850-384
 
NCGC00024928-01
NCGC00024928-03
NCGC00024928-04
NCGC00024928-05
NCGC00024928-07
NCGC00024928-08
NCGC00024928-09
NCGC00024928-12
NSC727681
Noltam
Nolvadex
Nolvadex-D
Nourytam
Novaldex
Novo-Tamoxifen
Oncomox
PMS-Tamoxifen
Pms-Tamoxifen
Prestwick2_000146
Prestwick3_000146
QTL1_000079
Retaxim
SMR000059172
ST50511785
Spectrum5_001417
Spectrum5_002043
T5648_SIGMA
TAMOXIFEN (TAMOXIFEN CITRATE (54965-24-1))
TRANS FORM OF TAMOXIFEN
Tamizam
Tamofen
Tamone
Tamoplex (TN)
Tamoxasta
Tamoxen
Tamoxifen
Tamoxifen (INN)
Tamoxifen (TN)
Tamoxifen (Z)
Tamoxifen Citrate
Tamoxifen [INN:BAN]
Tamoxifen and its salts
Tamoxifene
Tamoxifene [INN-French]
Tamoxifeno
Tamoxifeno [INN-Spanish]
Tamoxifenum
Tamoxifenum [INN-Latin]
Tamoxifène
Tocris-0999
Tomaxithen
Trans-Tamoxifen
UNII-094ZI81Y45
UPCMLD-DP027
Valodex
Zemide
cMAP_000044
nchembio.140-comp7
nchembio.76-comp1
nchembio732-comp3
tamoxifen
trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
trans-Tamoxifen
2HormonesPhase 414415
3Hormone AntagonistsPhase 413180
4AnalgesicsPhase 411733
5Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 413168
6Lipid Regulating AgentsPhase 42766
7Selective Estrogen Receptor ModulatorsPhase 4601
8Peripheral Nervous System AgentsPhase 423689
9Estrogen Receptor ModulatorsPhase 4645
10Hypolipidemic AgentsPhase 42785
11EstrogensPhase 42542
12Estrogen AntagonistsPhase 41349
13Anti-Inflammatory Agents, Non-SteroidalPhase 44443
14Anti-Inflammatory AgentsPhase 410729
15Analgesics, Non-NarcoticPhase 46501
16Antineoplastic Agents, HormonalPhase 45592
17AntimetabolitesPhase 412054
18Antirheumatic AgentsPhase 410956
19Dermatologic AgentsPhase 45806
20EfamolPhase 417
21Bone Density Conservation AgentsPhase 43376
22Evening PrimroseNutraceuticalPhase 46
23Pharmaceutical Solutions8192
24Immunoglobulins6394
25Autoantibodies130
26Antibodies6394

Interventional clinical trials:

(show all 17)
idNameStatusNCT IDPhase
1Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast CancerCompletedNCT00999921Phase 4
2Feasibility Study Assessing the Treatment of Fibroadenomata With a Circumferential Sonication Treatment With HIFUActive, not recruitingNCT02139683Phase 3
3Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)Active, not recruitingNCT02011919Phase 2, Phase 3
4MR Guided Focused Ultrasound Surgery in the Treatment of Breast FibroadenomasTerminatedNCT00147108Phase 3
5High Intensity Focused Ultrasound (HIFU) to Treat Breast FibroadenomaCompletedNCT01422629
6Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)CompletedNCT03022695
7ICE-SENSE™ Cryotherapy for Breast Fibroadenoma TrialCompletedNCT00910312
8Optical Tomography With Ultrasound GuidanceCompletedNCT00908609
9Treatment of Breast Fibroadenoma Targeted Tissue With HIFURecruitingNCT03044054
10Treatment of Breast Fibroadenoma With FastScan HIFURecruitingNCT02488655
11American Breast Laser Ablation Therapy EvaluationRecruitingNCT00807924
12Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 LesionsRecruitingNCT02638935
13Treatment of Breast Fibroadenoma With High Intensity Focused UltrasoundActive, not recruitingNCT02078011
14Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)Active, not recruitingNCT01331954
15LOUIS-3D Breast StudyActive, not recruitingNCT01755130
16Synthetic Aperture Radar Detection of Breast TumoursEnrolling by invitationNCT02493595
17Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood TestNot yet recruitingNCT02066025

Search NIH Clinical Center for Breast Fibroadenoma


Cochrane evidence based reviews: fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Genetic tests related to Breast Fibroadenoma:

id Genetic test Affiliating Genes
1 Fibroadenoma of the Breast27

Anatomical Context for Breast Fibroadenoma

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MalaCards organs/tissues related to Breast Fibroadenoma:

36
Breast, Lung

FMA organs/tissues related to Breast Fibroadenoma:

17
Breast

Publications for Breast Fibroadenoma

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Articles related to Breast Fibroadenoma:

(show top 50)    (show all 59)
idTitleAuthorsYear
1
Breast Fibroadenoma With Increased Activity on 68Ga DOTATATE PET/CT. (27879489)
2017
2
Primary Infarction of Breast Fibroadenoma in the Absence of Pregnancy or Lactation. (27670396)
2017
3
Invasive Ductal Carcinoma Displayed "Basal-Like" Feature Arising within a Breast Fibroadenoma. (27870335)
2016
4
Multimodality approach in the diagnosis and management of bilateral giant juvenile breast fibroadenoma. (27758851)
2016
5
Ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma-a multicenter experience. (25635224)
2015
6
Ultrasound-guided cryoablation of breast fibroadenoma: a pilot trial. (25408274)
2014
7
High resolution compression elastography and color doppler sonography in characterization of breast fibroadenoma. (25227197)
2014
8
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. (25038752)
2014
9
Fine-needle aspiration of gray zone lesions of the breast: fibroadenoma versus ductal carcinoma. (22936545)
2013
10
Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)
2013
11
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
12
Transaxillary approach with use of traction suture for excision of breast fibroadenoma: a new technique and its results. (22604577)
2012
13
Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. (21192183)
2011
14
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. (22011321)
2011
15
Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. (21733035)
2011
16
A clinical study on the resection of breast fibroadenoma using two types of incision. (22108740)
2011
17
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)
2011
18
Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. (21875284)
2011
19
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue. (22249796)
2011
20
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. (22121516)
2011
21
Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. (24376952)
2010
22
Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women. (21039041)
2010
23
Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (19897676)
2010
24
Ectopic breast fibroadenoma of the vulva. (19622961)
2009
25
Herb-related aneuploidy in breast fibroadenoma. (21686556)
2009
26
A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. (19211906)
2009
27
Recurrence of giant juvenile breast fibroadenoma in a girl with Turner's syndrome. (19492586)
2009
28
Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)
2008
29
Invasive mucinous carcinoma arising within breast fibroadenoma. (18841829)
2008
30
Breast fibroadenoma in female adolescents. (17206308)
2007
31
Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. (18094894)
2007
32
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. (16961651)
2006
33
Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. (16405127)
2005
34
Malignant transformation of a breast fibroadenoma to cystosarcoma phyllodes: case report and review of the literature. (15943412)
2005
35
Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. (16297109)
2005
36
p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. (15578730)
2005
37
Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. (15450823)
2004
38
Breast fibroadenoma in teenage females. (14768798)
2003
39
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
40
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)
2001
41
Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells. (10349403)
1999
42
Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. (9885614)
1999
43
Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. (10432878)
1999
44
Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. (9278103)
1997
45
Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)
1997
46
Breast fibroadenoma with atypical features: a case report. (8629423)
1996
47
Infarction of breast fibroadenoma in a postmenopausal woman. (8044310)
1994
48
Aspiration cytology of breast fibroadenoma with atypia. (1606889)
1992
49
Possibilities of the conventional and interventional sonography in diagnosis of breast fibroadenoma. (1841055)
1991
50
Medulloblastoma metastasizing to a breast fibroadenoma: a case report. (2021436)
1991

Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

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Pathways related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9CYP19A1, ESR1
2
Show member pathways
9.7ERBB2, ESR1, PGR

GO Terms for genes affiliated with Breast Fibroadenoma

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Cellular components related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.5KRT14, KRT15, KRT8, NME1
2nucleusGO:00056346.4ERBB2, ESR1, HMGA2, KRT14, KRT15, KRT8

Biological processes related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:000820910.5CYP19A1, ESR1
2intracellular steroid hormone receptor signaling pathwayGO:003051810.5ESR1, MED12
3transcription initiation from RNA polymerase II promoterGO:000636710.0ESR1, MED12, PGR
4cornificationGO:00702689.9KRT14, KRT15, KRT8
5uterus developmentGO:00600659.9CYP19A1, ESR1

Molecular functions related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00054969.9ESR1, PGR

Sources for Breast Fibroadenoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet