MCID: BRS053
MIFTS: 46

Breast Fibroadenoma malady

Categories: Cancer diseases, Genetic diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Breast Fibroadenoma

Aliases & Descriptions for Breast Fibroadenoma:

Name: Breast Fibroadenoma 12 52 14
Fibroadenoma 12 52 42 69
Fibroadenoma of Breast 12 29 69
Juvenile Fibroadenoma of Breast 12 69
Complex Fibroadenoma of Breast 12
Cellular Fibroadenoma 12
Juvenile Fibroadenoma 12

Classifications:



Summaries for Breast Fibroadenoma

Disease Ontology : 12 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

MalaCards based summary : Breast Fibroadenoma, also known as fibroadenoma, is related to breast giant fibroadenoma and multiple fibroadenomas of the breast. An important gene associated with Breast Fibroadenoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Signaling by ERBB4 and Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. The drugs Tamoxifen and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and breast, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 71 Fibroadenomas of the breast are benign tumors characterized by an admixture of stromal and epithelial... more...

Related Diseases for Breast Fibroadenoma

Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
id Related Disease Score Top Affiliating Genes
1 breast giant fibroadenoma 11.1
2 multiple fibroadenomas of the breast 11.0
3 breast pericanalicular fibroadenoma 11.0
4 mouth disease 10.3 ERBB2 PGR
5 pericardium leiomyoma 10.3 MED12 PGR
6 mucoepidermoid thyroid carcinoma 10.3 ERBB2 PGR
7 triple-receptor negative breast cancer 10.3 ERBB2 PGR
8 renal infectious disease 10.3 ERBB2 KRT8
9 skin sarcoma 10.3 ERBB2 PGR
10 bartholin's gland benign neoplasm 10.3 ESR1 PGR
11 cardiovascular organ benign neoplasm 10.3 ESR1 PGR
12 appendix leiomyoma 10.3 ESR1 PGR
13 bronchus adenoma 10.3 ESR1 PGR
14 ovarian benign neoplasm 10.3 ESR1 PGR
15 plexiform neurofibroma 10.3 ESR1 PGR
16 hereditary breast ovarian cancer 10.3 ERBB2 ESR1
17 paranasal sinus disease 10.3 ESR1 PGR
18 deafness, autosomal recessive 21 10.3 ESR1 PGR
19 atypical lipomatous tumor 10.3 ESR1 PGR
20 congenital disorder of glycosylation, type ic 10.2 ESR1 PGR
21 intestinal perforation 10.2 ESR1 PGR
22 perlman syndrome 10.2 ESR1 PGR
23 biemond syndrome 10.2 CYP19A1 PGR
24 glioma 10.2 ERBB2 ESR1 PGR
25 bladder adenocarcinoma 10.2 ESR1 PGR
26 cervical lymphoepithelioma-like carcinoma 10.2 ERBB2 ESR1 PGR
27 histiocytic and dendritic cell cancer 10.2 ERBB2 ESR1 PGR
28 poliomyelitis 10.2 ERBB2 ESR1 PGR
29 anal neuroendocrine tumor 10.2 ESR1 PGR
30 central nervous system mature teratoma 10.2 ERBB2 ESR1 PGR
31 postpartum depression 10.2 ERBB2 ESR1 PGR
32 combined t cell and b cell immunodeficiency 10.2 ERBB2 ESR1 PGR
33 anomalous left coronary artery from the pulmonary artery 10.2 ERBB2 ESR1 PGR
34 polyembryoma of the ovary 10.2 ERBB2 ESR1 PGR
35 fallopian tube carcinosarcoma 10.2 ERBB2 ESR1 PGR
36 sclerosing hemangioma 10.2 ERBB2 ESR1 PGR
37 osteogenesis imperfecta 10.2 CYP19A1 ESR1 PGR
38 organ system benign neoplasm 10.2 ERBB2 ESR1 PGR
39 his bundle tachycardia 10.2 ERBB2 ESR1 PGR
40 lung squamous cell carcinoma 10.2 KRT15 KRT8
41 her2-receptor positive breast cancer 10.2 ERBB2 ESR1 PGR
42 acute thyroiditis 10.2 CYP19A1 ESR1 PGR
43 perinatal jaundice due to hepatocellular damage 10.2 CYP19A1 ESR1 PGR
44 congenital bile acid synthesis defect 10.2 ERBB2 ESR1 PGR
45 epithelioid neurofibroma 10.2 ESR1 MED12 PGR
46 esophagus sarcoma 10.2 CYP19A1 ESR1 PGR
47 pyomyositis 10.2 ERBB2 ESR1 PGR
48 metagonimiasis 10.2 ERBB2 ESR1 PGR
49 pituitary stalk meningioma 10.2 ERBB2 ESR1 PGR
50 prostatic adenoma 10.2 ERBB2 ESR1 PGR

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to Breast Fibroadenoma

Symptoms & Phenotypes for Breast Fibroadenoma

MGI Mouse Phenotypes related to Breast Fibroadenoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 CYP19A1 ERBB2 ESR1 KRT8 MED12 NGFR
2 digestive/alimentary MP:0005381 9.91 CYP19A1 ERBB2 ESR1 KRT14 KRT8 NGFR
3 endocrine/exocrine gland MP:0005379 9.87 CYP19A1 ERBB2 ESR1 KRT14 NME1 PGR
4 integument MP:0010771 9.86 CYP19A1 ERBB2 ESR1 KRT14 MME NGFR
5 liver/biliary system MP:0005370 9.7 CYP19A1 ESR1 KRT8 MME NGFR NME1
6 neoplasm MP:0002006 9.43 ERBB2 ESR1 KRT14 NME1 PGR RASSF1
7 normal MP:0002873 9.17 ERBB2 ESR1 MED12 NGFR PGR RASSF1

Drugs & Therapeutics for Breast Fibroadenoma

Drugs for Breast Fibroadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 4 10540-29-1 2733526
2 Analgesics Phase 4
3 Analgesics, Non-Narcotic Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Antimetabolites Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Antirheumatic Agents Phase 4
9 Bone Density Conservation Agents Phase 4
10 Dermatologic Agents Phase 4
11 Efamol Phase 4
12 Estrogen Antagonists Phase 4
13 Estrogen Receptor Modulators Phase 4
14 Estrogens Phase 4
15 Hormone Antagonists Phase 4
16 Hormones Phase 4
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18 Hypolipidemic Agents Phase 4
19 Lipid Regulating Agents Phase 4
20 Peripheral Nervous System Agents Phase 4
21 Selective Estrogen Receptor Modulators Phase 4
22 Evening Primrose Nutraceutical Phase 4
23 Pharmaceutical Solutions
24 Antibodies
25 Autoantibodies
26 Immunoglobulins

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer Completed NCT00999921 Phase 4
2 Feasibility Study Assessing the Treatment of Fibroadenomata With a Circumferential Sonication Treatment With HIFU Active, not recruiting NCT02139683 Phase 3
3 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Active, not recruiting NCT02011919 Phase 2, Phase 3
4 MR Guided Focused Ultrasound Surgery in the Treatment of Breast Fibroadenomas Terminated NCT00147108 Phase 3
5 High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma Completed NCT01422629
6 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Completed NCT03022695
7 ICE-SENSEā„¢ Cryotherapy for Breast Fibroadenoma Trial Completed NCT00910312
8 Optical Tomography With Ultrasound Guidance Completed NCT00908609
9 Treatment of Breast Fibroadenoma Targeted Tissue With HIFU Recruiting NCT03044054
10 Treatment of Breast Fibroadenoma With FastScan HIFU Recruiting NCT02488655
11 American Breast Laser Ablation Therapy Evaluation Recruiting NCT00807924
12 Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 Lesions Recruiting NCT02638935
13 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound Active, not recruiting NCT02078011
14 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Active, not recruiting NCT01331954
15 LOUIS-3D Breast Study Active, not recruiting NCT01755130
16 Synthetic Aperture Radar Detection of Breast Tumours Enrolling by invitation NCT02493595
17 Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood Test Not yet recruiting NCT02066025

Search NIH Clinical Center for Breast Fibroadenoma

Cochrane evidence based reviews: fibroadenoma

Genetic Tests for Breast Fibroadenoma

Genetic tests related to Breast Fibroadenoma:

id Genetic test Affiliating Genes
1 Fibroadenoma of the Breast 29

Anatomical Context for Breast Fibroadenoma

MalaCards organs/tissues related to Breast Fibroadenoma:

39
Breast, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Breast Fibroadenoma:

18
Breast

Publications for Breast Fibroadenoma

Articles related to Breast Fibroadenoma:

(show top 50) (show all 59)
id Title Authors Year
1
Breast Fibroadenoma With Increased Activity on 68Ga DOTATATE PET/CT. ( 27879489 )
2017
2
Primary Infarction of Breast Fibroadenoma in the Absence of Pregnancy or Lactation. ( 27670396 )
2017
3
Invasive Ductal Carcinoma Displayed "Basal-Like" Feature Arising within a Breast Fibroadenoma. ( 27870335 )
2016
4
Multimodality approach in the diagnosis and management of bilateral giant juvenile breast fibroadenoma. ( 27758851 )
2016
5
Ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma-a multicenter experience. ( 25635224 )
2015
6
Ultrasound-guided cryoablation of breast fibroadenoma: a pilot trial. ( 25408274 )
2014
7
High resolution compression elastography and color doppler sonography in characterization of breast fibroadenoma. ( 25227197 )
2014
8
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. ( 25038752 )
2014
9
Fine-needle aspiration of gray zone lesions of the breast: fibroadenoma versus ductal carcinoma. ( 22936545 )
2013
10
Lobular intraepithelial neoplasia arising within breast fibroadenoma. ( 23849288 )
2013
11
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. ( 24089229 )
2013
12
Transaxillary approach with use of traction suture for excision of breast fibroadenoma: a new technique and its results. ( 22604577 )
2012
13
Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. ( 21192183 )
2011
14
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. ( 22011321 )
2011
15
Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. ( 21733035 )
2011
16
A clinical study on the resection of breast fibroadenoma using two types of incision. ( 22108740 )
2011
17
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. ( 21917252 )
2011
18
Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. ( 21875284 )
2011
19
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue. ( 22249796 )
2011
20
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. ( 22121516 )
2011
21
Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. ( 24376952 )
2010
22
Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women. ( 21039041 )
2010
23
Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. ( 19897676 )
2010
24
Ectopic breast fibroadenoma of the vulva. ( 19622961 )
2009
25
Herb-related aneuploidy in breast fibroadenoma. ( 21686556 )
2009
26
A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. ( 19211906 )
2009
27
Recurrence of giant juvenile breast fibroadenoma in a girl with Turner's syndrome. ( 19492586 )
2009
28
Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. ( 18090908 )
2008
29
Invasive mucinous carcinoma arising within breast fibroadenoma. ( 18841829 )
2008
30
Breast fibroadenoma in female adolescents. ( 17206308 )
2007
31
Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. ( 18094894 )
2007
32
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. ( 16961651 )
2006
33
Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. ( 16405127 )
2005
34
Malignant transformation of a breast fibroadenoma to cystosarcoma phyllodes: case report and review of the literature. ( 15943412 )
2005
35
Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. ( 16297109 )
2005
36
p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. ( 15578730 )
2005
37
Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. ( 15450823 )
2004
38
Breast fibroadenoma in teenage females. ( 14768798 )
2003
39
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. ( 15200048 )
2003
40
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. ( 11271786 )
2001
41
Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells. ( 10349403 )
1999
42
Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. ( 9885614 )
1999
43
Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. ( 10432878 )
1999
44
Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. ( 9278103 )
1997
45
Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. ( 9096642 )
1997
46
Breast fibroadenoma with atypical features: a case report. ( 8629423 )
1996
47
Infarction of breast fibroadenoma in a postmenopausal woman. ( 8044310 )
1994
48
Aspiration cytology of breast fibroadenoma with atypia. ( 1606889 )
1992
49
Possibilities of the conventional and interventional sonography in diagnosis of breast fibroadenoma. ( 1841055 )
1991
50
Medulloblastoma metastasizing to a breast fibroadenoma: a case report. ( 2021436 )
1991

Variations for Breast Fibroadenoma

Expression for Breast Fibroadenoma

Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for Breast Fibroadenoma

Pathways related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.17 ERBB2 ESR1 PGR
2 9.23 CYP19A1 ESR1

GO Terms for Breast Fibroadenoma

Cellular components related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.7 ERBB2 ESR1 HMGA2 KRT14 KRT15 KRT8
2 intermediate filament GO:0005882 8.92 KRT14 KRT15 KRT8 NME1

Biological processes related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.5 ESR1 MED12 PGR
2 androgen metabolic process GO:0008209 9.26 CYP19A1 ESR1
3 intracellular steroid hormone receptor signaling pathway GO:0030518 9.16 ESR1 MED12
4 uterus development GO:0060065 8.96 CYP19A1 ESR1
5 cornification GO:0070268 8.8 KRT14 KRT15 KRT8

Molecular functions related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Breast Fibroadenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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