MCID: BRS053
MIFTS: 44

Breast Fibroadenoma malady

Categories: Genetic diseases, Cancer diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Breast Fibroadenoma

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Aliases & Descriptions for Breast Fibroadenoma:

Name: Breast Fibroadenoma 10 47 12
Fibroadenoma 10 47 65
Juvenile Fibroadenoma of Breast 10 65
Fibroadenoma of Breast 10 65
 
Complex Fibroadenoma of Breast 10
Juvenile Fibroadenoma 10
Cellular Fibroadenoma 10

Classifications:



External Ids:

Disease Ontology10 DOID:1618
ICD1027 D24
MeSH36 D018226
UMLS65 C0178421, C0206650, C0346158 C1333137, more

Summaries for Breast Fibroadenoma

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Wikipedia:68 Fibroadenomas of the breast are benign tumors characterized by an admixture of stromal and epithelial... more...

MalaCards based summary: Breast Fibroadenoma, also known as fibroadenoma, is related to breast cancer and breast giant fibroadenoma. An important gene associated with Breast Fibroadenoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways is Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. Affiliated tissues include breast, breast and pituitary, and related mouse phenotypes are tumorigenesis and normal.

Disease Ontology:10 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

Related Diseases for Breast Fibroadenoma

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Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer26.2CYP19A1, ERBB2, ESR1, KRT14, KRT8, MKI67
2breast giant fibroadenoma11.2
3breast pericanalicular fibroadenoma11.1
4adenofibroma10.8ERBB2, PGR
5pituitary gland disease10.8ERBB2, ESR1
6her2-receptor positive breast cancer10.8ERBB2, PGR
7cribriform carcinoma10.7ERBB2, ESR1
8ovarian mesodermal adenosarcoma10.7ERBB2, PGR
9high molecular weight kininogen deficiency10.7ERBB2, ESR1
10syringoma10.7ESR1, PGR
11endocrine organ benign neoplasm10.7ESR1, PGR
12benign multicystic peritoneal mesothelioma10.7CYP19A1, PGR
13cervical benign neoplasm10.7ESR1, PGR
14large bowel leiomyoma10.7ESR1, PGR
15bile duct cystadenoma10.7ESR1, PGR
16venous tributary occlusion of retina10.7ESR1, PGR
17deafness, autosomal dominant 8/1210.7ESR1, PGR
18adult spinal cord ependymoma10.7ERBB2, KRT8
19vulvar squamous papilloma10.7ESR1, PGR
20extragonadal nonseminomatous germ cell tumor10.7ESR1, PGR
21esophageal adenoid cystic carcinoma10.7ESR1, PGR
22vulvar alveolar soft part sarcoma10.7ESR1, PGR
23acute retinal necrosis syndrome10.7ERBB2, PGR
24follicular basal cell carcinoma10.6ESR1, PGR
25childhood mediastinal neurogenic tumor10.6ESR1, PGR
26kidney leiomyosarcoma10.6ESR1, MKI67
27renal pelvis squamous cell carcinoma10.6ESR1, PGR
28intraventricular meningioma10.6ESR1, PGR
29large cell acanthoma10.6ESR1, PGR
30breast metaplastic carcinoma10.6ESR1, PGR
31skin amelanotic melanoma10.6CYP19A1, ESR1
32vulval paget's disease10.6ESR1, MKI67
33internal auditory canal lipoma10.6ESR1, PGR
34breast granular cell tumor10.6ERBB2, ESR1
35apocrine adenoma10.6KRT15, KRT8
36adenosarcoma of the uterus10.6ESR1, PGR
37metatypical basal cell carcinoma10.6KRT15, KRT8
38glaucoma iridogoniodysgenesia10.5ERBB2, ESR1, PGR
39situs inversus10.5ERBB2, ESR1, PGR
40childhood choriocarcinoma of the ovary10.5ERBB2, ESR1, PGR
41ureter adenocarcinoma10.5ERBB2, ESR1, PGR
42dental pulp calcification10.5ERBB2, ESR1, PGR
43apocrine adenosis of breast10.5ERBB2, ESR1, PGR
44exposure keratitis10.5ERBB2, ESR1, PGR
45breast benign neoplasm10.5ERBB2, ESR1, PGR
46gastric cardia carcinoma10.5ERBB2, ESR1, PGR
47benign breast phyllodes tumor10.5ESR1, MME
48periocular meningioma10.5ERBB2, ESR1, PGR
49retroperitoneal sarcoma10.5CYP19A1, ESR1, PGR
50papillary carcinoma10.5ERBB2, PGR

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to breast fibroadenoma

Symptoms for Breast Fibroadenoma

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Drugs & Therapeutics for Breast Fibroadenoma

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Drugs for Breast Fibroadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TamoxifenapprovedPhase 435010540-29-12733526
Synonyms:
(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene
(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(Para-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine
(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine (IUPAC)
(Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE
(Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
,citrate
1-P-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-Para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-.beta.-Dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
10540-29-1
1ya4
2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
54965-24-1 (citrate)
AC1MBZ3R
Apo-Tamox
Apo-tamox
BIDD:ER0008
BIDD:GT0009
BIDD:PXR0003
BPBio1_000278
BRD-K93754473-001-02-9
BRD-K93754473-048-05-3
BSPBio_000252
BSPBio_001150
BSPBio_001982
C07108
C26H29NO
CCRIS 3275
CHEBI:41774
CHEMBL83
CID2733526
Citofen
Crisafeno
D08559
DB00675
Diemon
EINECS 234-118-0
Gen-Tamoxifen
Gen-tamoxifen
HMS1362J11
HMS1792J11
HMS1990J11
HMS2090N08
HSDB 6782
ICI 47699
ICI-46,474
ICI-47699
IDI1_000258
IDI1_002170
Istubol
Kessar
L024126
LS-393
Lopac0_001203
MLS001332535
MLS001332536
MolPort-003-850-384
 
NCGC00024928-01
NCGC00024928-03
NCGC00024928-04
NCGC00024928-05
NCGC00024928-07
NCGC00024928-08
NCGC00024928-09
NCGC00024928-12
NSC727681
Noltam
Nolvadex
Nolvadex-D
Nourytam
Novaldex
Novo-Tamoxifen
Oncomox
PMS-Tamoxifen
Pms-Tamoxifen
Prestwick2_000146
Prestwick3_000146
QTL1_000079
Retaxim
SMR000059172
ST50511785
Soltamox
Spectrum5_001417
Spectrum5_002043
T5648_SIGMA
TAMOXIFEN (TAMOXIFEN CITRATE (54965-24-1))
TRANS FORM OF TAMOXIFEN
Tamizam
Tamofen
Tamone
Tamoplex (TN)
Tamoxasta
Tamoxen
Tamoxifen
Tamoxifen (INN)
Tamoxifen (TN)
Tamoxifen (Z)
Tamoxifen Citrate
Tamoxifen [INN:BAN]
Tamoxifen and its salts
Tamoxifene
Tamoxifene [INN-French]
Tamoxifeno
Tamoxifeno [INN-Spanish]
Tamoxifenum
Tamoxifenum [INN-Latin]
Tamoxifène
Tocris-0999
Tomaxithen
Trans-Tamoxifen
UNII-094ZI81Y45
UPCMLD-DP027
Valodex
Zemide
cMAP_000044
nchembio.140-comp7
nchembio.76-comp1
nchembio732-comp3
tamoxifen
trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
trans-Tamoxifen
2Hormone AntagonistsPhase 410002
3AnalgesicsPhase 49358
4Estrogen Receptor ModulatorsPhase 4544
5HormonesPhase 411748
6Hypolipidemic AgentsPhase 42228
7Selective Estrogen Receptor ModulatorsPhase 4501
8Peripheral Nervous System AgentsPhase 418510
9Estrogen AntagonistsPhase 41155
10Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 49988
11EstrogensPhase 42144
12AntimetabolitesPhase 49454
13EfamolPhase 416
14Anti-Inflammatory AgentsPhase 48478
15Analgesics, Non-NarcoticPhase 45184
16Antineoplastic Agents, HormonalPhase 44256
17Anti-Inflammatory Agents, Non-SteroidalPhase 43549
18Dermatologic AgentsPhase 44555
19Bone Density Conservation AgentsPhase 42600
20Antirheumatic AgentsPhase 48496
21Evening PrimroseNutraceuticalPhase 46
22Pharmaceutical Solutions7004
23Immunologic Factors18483
24Immunoglobulins4477
25Autoantibodies117
26Antibodies4477

Interventional clinical trials:

(show all 15)
idNameStatusNCT IDPhase
1Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast CancerCompletedNCT00999921Phase 4
2Feasibility Study Assessing the Treatment of Fibroadenomata With a Circumferential Sonication Treatment With HIFUActive, not recruitingNCT02139683Phase 3
3Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)Active, not recruitingNCT02011919Phase 2, Phase 3
4MR Guided Focused Ultrasound Surgery in the Treatment of Breast FibroadenomasTerminatedNCT00147108Phase 3
5Treatment of Breast Fibroadenoma With FastScan HIFURecruitingNCT02488655Phase 1
6High Intensity Focused Ultrasound (HIFU) to Treat Breast FibroadenomaCompletedNCT01422629
7ICE-SENSE™ Cryotherapy for Breast Fibroadenoma TrialCompletedNCT00910312
8Treatment of Breast Fibroadenoma With High Intensity Focused UltrasoundRecruitingNCT02078011
9American Breast Laser Ablation Therapy EvaluationRecruitingNCT00807924
10Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 LesionsRecruitingNCT02638935
11Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)Active, not recruitingNCT01331954
12LOUIS-3D Breast StudyActive, not recruitingNCT01755130
13Optical Tomography With Ultrasound GuidanceActive, not recruitingNCT00908609
14Synthetic Aperture Radar Detection of Breast TumoursEnrolling by invitationNCT02493595
15Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood TestNot yet recruitingNCT02066025

Search NIH Clinical Center for Breast Fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Anatomical Context for Breast Fibroadenoma

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MalaCards organs/tissues related to Breast Fibroadenoma:

33
Breast, Pituitary, Testes, Skin, Liver, Ovary, Prostate

FMA organs/tissues related to Breast Fibroadenoma:

16
Breast

Animal Models for Breast Fibroadenoma or affiliated genes

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MGI Mouse Phenotypes related to Breast Fibroadenoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0ERBB2, ESR1, KRT14, NME1, PGR, RASSF1
2MP:00028738.0CYP19A1, ERBB2, ESR1, MED12, MKI67, PGR
3MP:00107717.7CYP19A1, ERBB2, ESR1, KRT14, MME, NME1

Publications for Breast Fibroadenoma

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Articles related to Breast Fibroadenoma:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma-a multicenter experience. (25635224)
2015
2
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. (25038752)
2014
3
Ultrasound-guided cryoablation of breast fibroadenoma: a pilot trial. (25408274)
2014
4
High resolution compression elastography and color doppler sonography in characterization of breast fibroadenoma. (25227197)
2014
5
Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)
2013
6
Fine-needle aspiration of gray zone lesions of the breast: fibroadenoma versus ductal carcinoma. (22936545)
2013
7
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
8
Transaxillary approach with use of traction suture for excision of breast fibroadenoma: a new technique and its results. (22604577)
2012
9
A clinical study on the resection of breast fibroadenoma using two types of incision. (22108740)
2011
10
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. (22011321)
2011
11
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue. (22249796)
2011
12
Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. (21733035)
2011
13
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)
2011
14
Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. (21192183)
2011
15
Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. (21875284)
2011
16
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. (22121516)
2011
17
Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. (24376952)
2010
18
Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (19897676)
2010
19
A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. (19211906)
2009
20
Recurrence of giant juvenile breast fibroadenoma in a girl with Turner's syndrome. (19492586)
2009
21
Ectopic breast fibroadenoma of the vulva. (19622961)
2009
22
Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)
2008
23
Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. (18094894)
2007
24
Breast fibroadenoma in female adolescents. (17206308)
2007
25
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. (16961651)
2006
26
Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. (16297109)
2005
27
Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. (16405127)
2005
28
p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. (15578730)
2005
29
Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. (15450823)
2004
30
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
31
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)
2001
32
Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. (10432878)
1999
33
Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells. (10349403)
1999
34
Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. (9885614)
1999
35
Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. (9278103)
1997
36
Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)
1997
37
Breast fibroadenoma with atypical features: a case report. (8629423)
1996
38
Infarction of breast fibroadenoma in a postmenopausal woman. (8044310)
1994
39
Aspiration cytology of breast fibroadenoma with atypia. (1606889)
1992
40
Medulloblastoma metastasizing to a breast fibroadenoma: a case report. (2021436)
1991
41
Possibilities of the conventional and interventional sonography in diagnosis of breast fibroadenoma. (1841055)
1991
42
Risk factors for breast fibroadenoma in young women. (2766721)
1989
43
Carcinoma in a breast fibroadenoma. (3473866)
1987
44
Estrogen receptor in dissociated and cultured human breast fibroadenoma epithelial cells. (3828977)
1987
45
Morphometry of the breast fibroadenoma. (3562341)
1986
46
Management of breast fibroadenoma in women under 25 years of age. (3730963)
1986
47
A radiodiagnostic study of breast fibroadenoma. (2949499)
1985
48
Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells. (6164351)
1980
49
Breast fibroadenoma and cardiac anomaly associated with EMG (Beckwith-Wiedemann) syndrome. (430311)
1979
50
The myoepithelium in human breast fibroadenoma. (4452932)
1974

Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

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Pathways related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9CYP19A1, ESR1

GO Terms for genes affiliated with Breast Fibroadenoma

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Cellular components related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.6KRT14, KRT8

Sources for Breast Fibroadenoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet