MCID: BRS053
MIFTS: 39

Breast Fibroadenoma malady

Categories: Genetic diseases, Cancer diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Breast Fibroadenoma

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Aliases & Descriptions for Breast Fibroadenoma:

Name: Breast Fibroadenoma 10 47 12
Fibroadenoma 10 47 65
Juvenile Fibroadenoma of Breast 10 65
Fibroadenoma of Breast 10 65
 
Complex Fibroadenoma of Breast 10
Juvenile Fibroadenoma 10
Cellular Fibroadenoma 10

Classifications:



External Ids:

Disease Ontology10 DOID:1618
ICD1027 D24
MeSH36 D018226
UMLS65 C0178421, C0206650, C0346158 C1333137, more

Summaries for Breast Fibroadenoma

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Wikipedia:68 Fibroadenomas of the breast are benign tumors characterized by an admixture of stromal and epithelial... more...

MalaCards based summary: Breast Fibroadenoma, also known as fibroadenoma, is related to breast giant fibroadenoma and breast pericanalicular fibroadenoma. An important gene associated with Breast Fibroadenoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways is Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. Affiliated tissues include breast, breast and testes, and related mouse phenotypes are tumorigenesis and normal.

Disease Ontology:10 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

Related Diseases for Breast Fibroadenoma

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Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1breast giant fibroadenoma11.6
2breast pericanalicular fibroadenoma11.5
3multiple fibroadenomas of the breast10.5
4adenofibroma10.5ERBB2, PGR
5pituitary gland disease10.5ERBB2, ESR1
6her2-receptor positive breast cancer10.5ERBB2, PGR
7cribriform carcinoma10.5ERBB2, ESR1
8ovarian mesodermal adenosarcoma10.5ERBB2, PGR
9high molecular weight kininogen deficiency10.5ERBB2, ESR1
10syringoma10.5ESR1, PGR
11endocrine organ benign neoplasm10.5ESR1, PGR
12benign multicystic peritoneal mesothelioma10.5CYP19A1, PGR
13cervical benign neoplasm10.5ESR1, PGR
14large bowel leiomyoma10.5ESR1, PGR
15bile duct cystadenoma10.5ESR1, PGR
16venous tributary occlusion of retina10.5ESR1, PGR
17deafness, autosomal dominant 8/1210.5ESR1, PGR
18adult spinal cord ependymoma10.5ERBB2, KRT8
19vulvar squamous papilloma10.5ESR1, PGR
20extragonadal nonseminomatous germ cell tumor10.4ESR1, PGR
21esophageal adenoid cystic carcinoma10.4ESR1, PGR
22vulvar alveolar soft part sarcoma10.4ESR1, PGR
23acute retinal necrosis syndrome10.4ERBB2, PGR
24follicular basal cell carcinoma10.4ESR1, PGR
25childhood mediastinal neurogenic tumor10.4ESR1, PGR
26kidney leiomyosarcoma10.4ESR1, MKI67
27renal pelvis squamous cell carcinoma10.4ESR1, PGR
28intraventricular meningioma10.4ESR1, PGR
29large cell acanthoma10.4ESR1, PGR
30breast metaplastic carcinoma10.4ESR1, PGR
31skin amelanotic melanoma10.4CYP19A1, ESR1
32vulval paget's disease10.4ESR1, MKI67
33internal auditory canal lipoma10.4ESR1, PGR
34breast granular cell tumor10.4ERBB2, ESR1
35apocrine adenoma10.4KRT15, KRT8
36adenosarcoma of the uterus10.4ESR1, PGR
37metatypical basal cell carcinoma10.4KRT15, KRT8
38glaucoma iridogoniodysgenesia10.3ERBB2, ESR1, PGR
39situs inversus10.3ERBB2, ESR1, PGR
40childhood choriocarcinoma of the ovary10.3ERBB2, ESR1, PGR
41ureter adenocarcinoma10.3ERBB2, ESR1, PGR
42dental pulp calcification10.3ERBB2, ESR1, PGR
43apocrine adenosis of breast10.3ERBB2, ESR1, PGR
44exposure keratitis10.3ERBB2, ESR1, PGR
45breast benign neoplasm10.3ERBB2, ESR1, PGR
46gastric cardia carcinoma10.3ERBB2, ESR1, PGR
47benign breast phyllodes tumor10.3ESR1, MME
48periocular meningioma10.3ERBB2, ESR1, PGR
49retroperitoneal sarcoma10.3CYP19A1, ESR1, PGR
50papillary carcinoma10.3ERBB2, PGR

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to breast fibroadenoma

Symptoms for Breast Fibroadenoma

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Drugs & Therapeutics for Breast Fibroadenoma

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Drugs for Breast Fibroadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TamoxifenapprovedPhase 435010540-29-12733526
Synonyms:
(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene
(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(Para-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine
(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine (IUPAC)
(Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE
(Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
,citrate
1-P-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-Para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-.beta.-Dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
10540-29-1
1ya4
2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
54965-24-1 (citrate)
AC1MBZ3R
Apo-Tamox
Apo-tamox
BIDD:ER0008
BIDD:GT0009
BIDD:PXR0003
BPBio1_000278
BRD-K93754473-001-02-9
BRD-K93754473-048-05-3
BSPBio_000252
BSPBio_001150
BSPBio_001982
C07108
C26H29NO
CCRIS 3275
CHEBI:41774
CHEMBL83
CID2733526
Citofen
Crisafeno
D08559
DB00675
Diemon
EINECS 234-118-0
Gen-Tamoxifen
Gen-tamoxifen
HMS1362J11
HMS1792J11
HMS1990J11
HMS2090N08
HSDB 6782
ICI 47699
ICI-46,474
ICI-47699
IDI1_000258
IDI1_002170
Istubol
Kessar
L024126
LS-393
Lopac0_001203
MLS001332535
MLS001332536
MolPort-003-850-384
 
NCGC00024928-01
NCGC00024928-03
NCGC00024928-04
NCGC00024928-05
NCGC00024928-07
NCGC00024928-08
NCGC00024928-09
NCGC00024928-12
NSC727681
Noltam
Nolvadex
Nolvadex-D
Nourytam
Novaldex
Novo-Tamoxifen
Oncomox
PMS-Tamoxifen
Pms-Tamoxifen
Prestwick2_000146
Prestwick3_000146
QTL1_000079
Retaxim
SMR000059172
ST50511785
Soltamox
Spectrum5_001417
Spectrum5_002043
T5648_SIGMA
TAMOXIFEN (TAMOXIFEN CITRATE (54965-24-1))
TRANS FORM OF TAMOXIFEN
Tamizam
Tamofen
Tamone
Tamoplex (TN)
Tamoxasta
Tamoxen
Tamoxifen
Tamoxifen (INN)
Tamoxifen (TN)
Tamoxifen (Z)
Tamoxifen Citrate
Tamoxifen [INN:BAN]
Tamoxifen and its salts
Tamoxifene
Tamoxifene [INN-French]
Tamoxifeno
Tamoxifeno [INN-Spanish]
Tamoxifenum
Tamoxifenum [INN-Latin]
Tamoxifène
Tocris-0999
Tomaxithen
Trans-Tamoxifen
UNII-094ZI81Y45
UPCMLD-DP027
Valodex
Zemide
cMAP_000044
nchembio.140-comp7
nchembio.76-comp1
nchembio732-comp3
tamoxifen
trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
trans-Tamoxifen
2Hormone AntagonistsPhase 410002
3AnalgesicsPhase 49358
4Estrogen Receptor ModulatorsPhase 4544
5HormonesPhase 411748
6Hypolipidemic AgentsPhase 42228
7Selective Estrogen Receptor ModulatorsPhase 4501
8Peripheral Nervous System AgentsPhase 418510
9Estrogen AntagonistsPhase 41155
10Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 49988
11EstrogensPhase 42144
12AntimetabolitesPhase 49454
13EfamolPhase 416
14Anti-Inflammatory AgentsPhase 48478
15Analgesics, Non-NarcoticPhase 45184
16Antineoplastic Agents, HormonalPhase 44256
17Anti-Inflammatory Agents, Non-SteroidalPhase 43549
18Dermatologic AgentsPhase 44555
19Bone Density Conservation AgentsPhase 42600
20Antirheumatic AgentsPhase 48496
21Evening PrimroseNutraceuticalPhase 46
22Pharmaceutical Solutions7004
23Immunologic Factors18483
24Immunoglobulins4477
25Autoantibodies117
26Antibodies4477

Interventional clinical trials:

(show all 15)
idNameStatusNCT IDPhase
1Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast CancerCompletedNCT00999921Phase 4
2Feasibility Study Assessing the Treatment of Fibroadenomata With a Circumferential Sonication Treatment With HIFUActive, not recruitingNCT02139683Phase 3
3Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)Active, not recruitingNCT02011919Phase 2, Phase 3
4MR Guided Focused Ultrasound Surgery in the Treatment of Breast FibroadenomasTerminatedNCT00147108Phase 3
5Treatment of Breast Fibroadenoma With FastScan HIFURecruitingNCT02488655Phase 1
6High Intensity Focused Ultrasound (HIFU) to Treat Breast FibroadenomaCompletedNCT01422629
7ICE-SENSE™ Cryotherapy for Breast Fibroadenoma TrialCompletedNCT00910312
8Treatment of Breast Fibroadenoma With High Intensity Focused UltrasoundRecruitingNCT02078011
9American Breast Laser Ablation Therapy EvaluationRecruitingNCT00807924
10Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 LesionsRecruitingNCT02638935
11Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)Active, not recruitingNCT01331954
12LOUIS-3D Breast StudyActive, not recruitingNCT01755130
13Optical Tomography With Ultrasound GuidanceActive, not recruitingNCT00908609
14Synthetic Aperture Radar Detection of Breast TumoursEnrolling by invitationNCT02493595
15Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood TestNot yet recruitingNCT02066025

Search NIH Clinical Center for Breast Fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Anatomical Context for Breast Fibroadenoma

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MalaCards organs/tissues related to Breast Fibroadenoma:

33
Breast, Testes, Bone, Skin, Prostate, Adipocyte, Monocytes

FMA organs/tissues related to Breast Fibroadenoma:

16
Breast

Animal Models for Breast Fibroadenoma or affiliated genes

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MGI Mouse Phenotypes related to Breast Fibroadenoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0ERBB2, ESR1, KRT14, NME1, PGR, RASSF1
2MP:00028738.0CYP19A1, ERBB2, ESR1, MED12, MKI67, PGR
3MP:00107717.7CYP19A1, ERBB2, ESR1, KRT14, MME, NME1

Publications for Breast Fibroadenoma

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Articles related to Breast Fibroadenoma:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Enhanced M1/M2 Macrophage Ratio Promotes Orthodontic Root Resorption. (25344334)
2014
2
One case of swine hepatitis E virus and porcine reproductive and respiratory syndrome virus Co-infection in weaned pigs. (24252365)
2013
3
The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. (24114842)
2013
4
High IGFBP2 levels are not only associated with a better metabolic risk profile but also with increased mortality in elderly men. (22555360)
2012
5
Single site venovenous extracorporeal membrane oxygenation as an alternative to invasive ventilation in post-pneumonectomy fistula with acute respiratory failure. (22219410)
2012
6
Diagnostic role of inhibin I+-subunit and inhibin/activin I^-subunit in adrenal cortical and medullary tumors in Egyptian patients. (22417854)
2012
7
Regulation of ADP-ribosylation factor 4 expression by small leucine zipper protein and involvement in breast cancer cell migration. (22004728)
2012
8
Ogilvie syndrome: a rare but lethal intestinal complication of coronary revascularization. (22591944)
2012
9
Diagnostic and therapeutic challenges of intracranial hemorrhage in neonates with congenital hemophilia: a case report and review. (23049462)
2012
10
Structure and dynamics of a stabilized coiled-coil domain in the P-TEFb regulator Hexim1. (22033481)
2011
11
Colocolonic intussusception with a leading point. (21070875)
2011
12
Assessment of RNA amplification by multiplex RT-PCR and IgM detection by indirect and capture ELISAs for the diagnosis of measles and rubella. (20132186)
2010
13
The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. (20038815)
2010
14
Targeting the Nrf2 pathway against cardiovascular disease. (19530984)
2009
15
Formation of a human-derived fat tissue layer in P(DL)LGA hollow fibre scaffolds for adipocyte tissue engineering. (19135718)
2009
16
Structure of human argininosuccinate synthetase. (18323623)
2008
17
Androgen induces adaptation to oxidative stress in prostate cancer: implications for treatment with radiation therapy. (17325745)
2007
18
Parabolas of medication use and discontinuation after myocardial infarction--are we closing the treatment gap? (17486661)
2007
19
Monoamine oxidases: activities, genotypes and the shaping of behaviour. (17426915)
2007
20
Autologous transfusion with modified total hepatic vascular exclusion for extracapsular resection of giant hepatic cavernous hemangioma. (17287165)
2007
21
Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression. (16510494)
2006
22
Pleomorphic adenoma of the vulva: a review illustrated by a clinical case. (16681787)
2006
23
Results of an accelerated Ponseti protocol for clubfoot. (16199943)
2005
24
Decreased expression of lysyl hydroxylase 2 (LH2) in skin fibroblasts from three Ehlers-Danlos patients does not result from mutations in either the coding or proximal promoter region of the LH2 gene. (15589118)
2004
25
Osteoporosis associated with inflammatory bowel diseases]. (15202326)
2004
26
Identification of the antineoplastic agent 6-mercaptopurine as an activator of the orphan nuclear hormone receptor Nurr1. (12709433)
2003
27
Expression and activation of the nerve growth factor receptor TrkA in serous ovarian carcinoma. (12796393)
2003
28
Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse. (11248103)
2001
29
The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression. (10873384)
2000
30
Functional analysis of human ornithine decarboxylase alleles. (11103791)
2000
31
hOGG1 Ser326Cys polymorphism and lung cancer susceptibility. (10744126)
1999
32
Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells. (10024510)
1999
33
Plasma homovanillic acid and the dopamine transporter during cocaine withdrawal. (9513737)
1998
34
Somatic and renal effects of growth hormone in rats with chronic renal failure. (9203173)
1997
35
Age-related differences in outcome and severity of DIC in children with septic shock and purpura. (8972013)
1996
36
Hantavirus pulmonary syndrome in California: report of two cases and investigation. (7888541)
1994
37
cAMP modulates stress protein synthesis in human monocytes-macrophages. (7929603)
1994
38
Autocrine downregulation of fibroblast growth factor receptors in F9 teratocarcinoma cells. (8077293)
1994
39
Evolution and taxonomy of positive-strand RNA viruses: implications of comparative analysis of amino acid sequences. (8269709)
1993
40
Peptide alpha-amidation and peptidylglycine alpha-hydroxylating monooxygenase: control by disulfiram. (8246921)
1993
41
Histologic findings are not correlated with disaccharidase activities in infants with protracted diarrhea. (1905750)
1991
42
Thoracic spondylosis: an unusual cause of myelopathy. (3587552)
1987
43
Multiple genes encode the human Na+,K+-ATPase catalytic subunit. (3035563)
1987
44
Case report 354: Chondroma of soft tissues with dystrophic calcification. (3961527)
1986
45
A study of clinico-histologic correlation in lesions of borderline leprosy with multiple skin biopsies from different sites. (6668926)
1983
46
Peculiar face, pectus carinatum and joint laxity in brother and sister. (7438507)
1980
47
Purine excretion in complete adenine phosphoribosyltransferase deficiency: effect of diet and allopurinol therapy. (857624)
1977
48
Pregnancy and delivery following bilateral ureteral transplantation to the bowel for exstrophy of the bladder. (6044593)
1967
49
The value of the double-track sign as a differentiating factor between pylorospasm and hypertrophic pyloric stenosis in infants. (5934325)
1966
50
Meconium Ileus with Congenital Stenosis of the Main Pancreatic Duct. (19969848)
1929

Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

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Pathways related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9CYP19A1, ESR1

GO Terms for genes affiliated with Breast Fibroadenoma

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Cellular components related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:00450959.6KRT14, KRT8

Sources for Breast Fibroadenoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet