MCID: BRS053
MIFTS: 51

Breast Fibroadenoma malady

Summaries for Breast Fibroadenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Fibroadenomas of the breast are lumps composed of fibrous and glandular tissue. Because breast cancer... more...

MalaCards: Breast Fibroadenoma, also known as fibroadenoma, is related to breast cancer and adenoma. An important gene associated with Breast Fibroadenoma is HIF1A (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)), and among its related pathways are Nanog in Mammalian ESC Pluripotency and Angiogenesis. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and thyroid, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Breast Fibroadenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

breast fibroadenoma 8 10 44
fibroadenoma 8 44 60
juvenile fibroadenoma of breast 8 60
fibroadenoma of breast 8 60
complex fibroadenoma of the breast 8
fibroadenoma, no icd-o subtype 8
complex fibroadenoma of breast 8
juvenile fibroadenoma 8
cellular fibroadenoma 8
fibroadenoma nos 8


Related Diseases for Breast Fibroadenoma

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17GeneCards, 18GeneDecks
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Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer30.3VIM, PRLR, HIF1A, CYP19A1, FGF1, PGR
2adenoma30.1PRL, PRLR, FGFR4, FGF1
3ductal carcinoma in situ30.1ESR1, ERBB2, PGR
4myoma30.1CYP19A1, PGR, ESR1
5li-fraumeni syndrome30.0PRLR, CYP19A1, PGR, ERBB2, ESR1
6angiosarcoma29.8VIM
7gynecomastia29.8PRL, CYP19A1, PGR, ESR1
8breast giant fibroadenoma10.3
9multiple fibroadenomas of the breast10.3
10breast malignant phyllodes tumor10.2
11breast pericanalicular fibroadenoma10.1
12chickenpox10.1
13in situ carcinoma10.1
14neurofibromatosis10.1
15androgen insensitivity syndrome10.1
16granular cell tumor10.1
17breast granular cell tumor10.1
18giant cell tumor10.1
19transsexualism10.1
20beckwith-wiedemann syndrome10.1
21breast lymphoma10.1
22lobular neoplasia10.1
23breast mucinous carcinoma10.1
24hodgkin's lymphoma10.1
25medulloblastoma10.1
26breast intracanalicular fibroadenoma10.0
27breast fibroadenosis10.0
28obesity10.0HIF1A
29arthritis10.0FGF1
30tongue cancer10.0PRLR
31rheumatoid arthritis10.0PRLR
32alzheimer's disease10.0FGF1
33leydig cell tumor10.0CYP19A1
34osteoarthritis10.0FGF1
35lung cancer10.0ERBB2
36neuroendocrine tumor10.0PRL
37uterine carcinosarcoma10.0ERBB2
38craniopharyngioma10.0PRL
39aromatase deficiency10.0CYP19A1
40pheochromocytoma10.0FGF1, HIF1A
41sertoli-leydig cell tumor10.0PGR
42cervical cancer10.0HIF1A
43malignant glioma10.0HIF1A
44cushing's syndrome10.0PRL
45gastrointestinal stromal tumor10.0VIM
46chordoma10.0VIM
47hyperprolactinemia10.0PRLR, PRL
48rhabdomyosarcoma10.0VIM
49schizophrenia10.0PRL
50hypogonadism, hypergonadotropic10.0CYP19A1, PRL

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to breast fibroadenoma

Clinical Features for Breast Fibroadenoma

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Drugs & Therapeutics for Breast Fibroadenoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Breast Fibroadenoma

Drug clinical trials:

Search ClinicalTrials for Breast Fibroadenoma

Search NIH Clinical Center for Breast Fibroadenoma

Search CenterWatch for Breast Fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Anatomical Context for Breast Fibroadenoma

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32MalaCards
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MalaCards organs/tissues related to Breast Fibroadenoma:

32
Breast, Lung, Thyroid, Prostate

Animal Models for Breast Fibroadenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Breast Fibroadenoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.3PRLR
2MP:001077110.1HIF1A, PRLR
3MP:00053899.6PRL, PRLR, ERBB2
4MP:00053699.2HIF1A, CYP19A1, ESR1
5MP:00053768.3PRL, PRLR, FGFR4, FGF1, PGR, ESR1
6MP:00053908.1HIF1A, CYP19A1, PGR, ERBB2, ESR1, PRLR
7MP:00020068.0ESR1, PRL, PRLR, HIF1A, FGFR4, PGR
8MP:00053807.6VIM, PRL, PRLR, HIF1A, PGR, ERBB2
9MP:00036317.3VIM, PRL, PRLR, HIF1A, CYP19A1, FGF1
10MP:00053867.2VIM, PRL, PRLR, HIF1A, CYP19A1, PGR
11MP:00053847.0VIM, PRLR, HIF1A, CYP19A1, FGFR4, PGR

Publications for Breast Fibroadenoma

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50PubMed
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Articles related to Breast Fibroadenoma:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Bilateral axillary masses mimicking as accessory breast with multiple fibroadenoma and bilateral gigantomastia in HIV-positive patient. (23813993)
2013
2
Fine-needle aspiration of gray zone lesions of the breast: fibroadenoma versus ductal carcinoma. (22936545)
2013
3
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
4
Transaxillary approach with use of traction suture for excision of breast fibroadenoma: a new technique and its results. (22604577)
2012
5
Juvenile fibroadenoma and granular cell tumor of the breast in an adolescent. (23084210)
2012
6
A clinical study on the resection of breast fibroadenoma using two types of incision. (22108740)
2011
7
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue. (22249796)
2011
8
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)
2011
9
Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. (21192183)
2011
10
Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. (21875284)
2011
11
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. (22121516)
2011
12
Intraductal fibroadenoma and intraductal phyllodes tumour--a part of the spectrum of the breast ductal adenoma? (20013344)
2010
13
Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women. (21039041)
2010
14
Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast. (18789487)
2009
15
Recurrence of giant juvenile breast fibroadenoma in a girl with Turner's syndrome. (19492586)
2009
16
Ectopic breast fibroadenoma of the vulva. (19622961)
2009
17
Herb-related aneuploidy in breast fibroadenoma. (21686556)
2009
18
Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)
2008
19
Morphologic changes in fibroadenoma of breast due to chickenpox: a case report with suspicious cytology in fine needle aspiration smears. (18540301)
2008
20
Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. (18094894)
2007
21
Breast fibroadenoma in female adolescents. (17206308)
2007
22
Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma. (16608396)
2006
23
Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast. (16554735)
2006
24
p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. (15578730)
2005
25
Association of viral factors with non-familial breast cancer in Taiwan by comparison with non-cancerous, fibroadenoma, and thyroid tumor tissues. (15602723)
2005
26
Concurrent fibroadenoma of breast and fibromatosis of vulva and thigh. (19810314)
2005
27
Malignant transformation of a breast fibroadenoma to cystosarcoma phyllodes: case report and review of the literature. (15943412)
2005
28
Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. (15450823)
2004
29
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
30
Beta-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast. (12898599)
2003
31
Breast fibroadenoma in teenage females. (14768798)
2003
32
Expression of CD34 and bcl-2 in phyllodes tumours, fibroadenomas and spindle cell lesions of the breast. (11135048)
2001
33
A 19 year old with complete androgen insensitivity syndrome and juvenile fibroadenoma of the breast. (11843857)
2001
34
Absence of genetic abnormalities in fibroadenomas of the breast determined at p53 gene mutations and microsatellite alterations. (11691818)
2001
35
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)
2001
36
Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells. (10349403)
1999
37
Elevated levels of prostate-specific antigen in serum of women with fibroadenomas and breast cysts. (9106652)
1997
38
Variation of bcl-2 expression in breast ducts and lobules in relation to plasma progesterone levels: overexpression and absence of variation in fibroadenomas. (9390034)
1997
39
High expression of the EGFR in fibroadenomas compared to breast carcinomas. (7847801)
1994
40
Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma, and gynecomastia. Relationship to histologic grade and clinical parameters. (7911069)
1994
41
Infarction of breast fibroadenoma in a postmenopausal woman. (8044310)
1994
42
Expression of beta 1 integrins in non-neoplastic mammary epithelium, fibroadenoma and carcinoma of the breast. (8493776)
1993
43
Aspiration cytology of breast fibroadenoma with atypia. (1606889)
1992
44
Risk factors for breast fibroadenoma in young women. (2766721)
1989
45
Carcinoma in a breast fibroadenoma. (3473866)
1987
46
Estrogen receptor in dissociated and cultured human breast fibroadenoma epithelial cells. (3828977)
1987
47
Morphometry of the breast fibroadenoma. (3562341)
1986
48
Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells. (6164351)
1980
49
Breast fibroadenoma and cardiac anomaly associated with EMG (Beckwith-Wiedemann) syndrome. (430311)
1979
50
Bilateral fibroadenoma in supernumerary breasts of the vulva. (5775152)
1969

Genetic Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Fibroadenoma

Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

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Sources:
51QIAGEN, 4Cell Signaling Technology, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7FGFR4, VIM
29.6HIF1A, FGFR4, FGF1
3
Hide members
9.5ESR1, CYP19A1
49.5ERBB2, FGF1, FGFR4
5
Hide members
9.5ERBB2, FGF1, FGFR4
69.4PRL, PRLR, ERBB2
79.4PRLR, CYP19A1, PGR
8
Hide members
9.3PRL, PRLR, PGR
9
Development Ligand-dependent activation of the ESR1/AP-1 pathway
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9.3ESR1, HIF1A, PRLR
109.2PRL, PRLR, FGFR4, FGF1
118.9HIF1A, FGF1, ERBB2, ESR1
128.9ERBB2, FGF1, FGFR4, HIF1A, PRL
13
Hide members
8.8ERBB2, FGF1, FGFR4, PRLR, PRL
14
Development Prolactin receptor signaling
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8.7ESR1, ERBB2, PRLR, PRL
15
Hide members
8.1VIM, HIF1A, FGFR4, FGF1, ERBB2, ESR1
16
Hide members
7.7ESR1, PRL, PRLR, FGFR4, FGF1, PGR
17
Hide members
7.5PRL, PRLR, HIF1A, FGFR4, FGF1, PGR

Compounds for genes affiliated with Breast Fibroadenoma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6ARSH
2dexamethasone44 49 28 1113.0PRLR, HIF1A, FGF1
3idoxifene449.4CYP19A1, PGR, ESR1
45fluorouracil449.4PGR, HIF1A, ERBB2
5fadrozole449.3CYP19A1, ERBB2, ESR1
6danazol44 11 2411.2ESR1, ARSH, PGR, CYP19A1
7tibolone449.1ARSH, ESR1, PGR, CYP19A1
8gnrh449.1CYP19A1, ERBB2, ARSH, PRLR, PGR
9estradiol benzoate449.1ESR1, PGR, CYP19A1, PRL
10leuprolide acetate449.1PRL, ESR1, PGR, CYP19A1
11megestrol acetate449.0CYP19A1, ESR1, ERBB2, PGR
12clomiphene citrate449.0PGR, CYP19A1, PRL, ESR1
13steroidal449.0PGR, ESR1, ARSH, CYP19A1
14anastrozole44 1110.0ESR1, ERBB2, PGR, CYP19A1
15exemestane49 44 59 1112.0CYP19A1, PGR, ERBB2, ESR1
16lapatinib44 49 1111.0ESR1, PGR, CYP19A1, ERBB2
17levonorgestrel44 59 28 1112.0ESR1, PGR, CYP19A1, PRL
18fulvestrant44 49 28 1112.0CYP19A1, PGR, ESR1, ERBB2
19taxane449.0ERBB2, PGR, CYP19A1, ESR1
20flutamide44 59 1111.0PRL, ESR1, PGR, CYP19A1
21bisphenol a449.0PGR, ARSH, HIF1A, CYP19A1, ESR1
22letrozole44 49 59 1112.0ESR1, CYP19A1, ERBB2, PGR
23progestins448.9ESR1, CYP19A1, PGR, PRLR, ARSH
2417beta-hydroxysteroid448.9PGR, CYP19A1, ESR1, ARSH
25estrone sulfate44 249.8PGR, ARSH, PRL, CYP19A1, ESR1
26hydrocortisone44 2 59 1111.8FGF1, ERBB2, CYP19A1, PRL, VIM
27trastuzumab44 49 1110.8HIF1A, CYP19A1, PGR, ERBB2, ESR1
28geldanamycin44 49 59 1111.8ESR1, ERBB2, PGR, FGF1, HIF1A
29nandrolone44 249.8ESR1, CYP19A1, PGR
30estrone44 28 11 2411.7PRL, CYP19A1, PGR, ESR1, ARSH
31toremifene44 119.7ESR1, ERBB2, PGR, CYP19A1, PRL
32n-(4-hydroxyphenyl)retinamide448.7CYP19A1, ESR1, ERBB2, VIM
33paclitaxel44 49 1110.7CYP19A1, PGR, ERBB2, ESR1, HIF1A
34docetaxel44 49 59 1111.6CYP19A1, ERBB2, HIF1A, PGR, ESR1
35raloxifene44 28 49 1111.5ERBB2, CYP19A1, PGR, ESR1
36cyclophosphamide44 49 1110.5ERBB2, HIF1A, PGR, CYP19A1, ESR1
37steroid448.3ARSH, PRLR, PRL, CYP19A1, ESR1, ERBB2
384-hydroxytamoxifen448.3ESR1, VIM, ARSH, CYP19A1, PGR, ERBB2
39methotrexate44 49 1110.2ESR1, ERBB2, PGR, CYP19A1, HIF1A, VIM
40arginine448.1CYP19A1, FGFR4, ERBB2, HIF1A, PRL, FGF1
41dihydrotestosterone44 28 11 2411.1PGR, CYP19A1, HIF1A, PRL, VIM, ESR1
42doxorubicin44 49 1110.1PGR, ERBB2, CYP19A1, VIM, ESR1, HIF1A
43estradiol44 11 2410.0PRLR, PRL, ARSH, VIM, PGR, CYP19A1
44paraffin447.7PRLR, ESR1, ERBB2, PGR, FGF1, FGFR4
45genistein44 28 59 2 11 2412.7PGR, ERBB2, ESR1, FGF1, HIF1A, PRLR
46vegf447.6HIF1A, FGF1, FGFR4, ERBB2, ESR1, VIM
47progestin447.6PGR, PRL, PRLR, CYP19A1, ERBB2, ESR1
48progesterone44 59 28 11 2411.6VIM, PRLR, CYP19A1, PRL, PGR, ERBB2
49tamoxifen44 49 28 1110.1ESR1, ERBB2, PGR, FGF1, CYP19A1, HIF1A
50testosterone44 59 11 2410.1ERBB2, CYP19A1, PRLR, PRL, ARSH, ESR1

GO Terms for genes affiliated with Breast Fibroadenoma

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16Gene Ontology
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Biological processes related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1organ inductionGO:00175910.1FGFR4, FGF1
2positive regulation of nitric-oxide synthase activityGO:0510009.8ESR1, HIF1A
3JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.8PRLR, PRL
4lactationGO:0075959.8HIF1A, PRLR, PRL
5androgen metabolic processGO:0082099.7ESR1, CYP19A1
6positive regulation of epithelial cell proliferationGO:0506799.6ERBB2, FGF1, PRL
7phosphatidylinositol-mediated signalingGO:0480159.6ERBB2, FGF1, FGFR4
8steroid biosynthetic processGO:0066949.5CYP19A1, PRLR
9fibroblast growth factor receptor signaling pathwayGO:0085439.4FGFR4, FGF1, ERBB2
10cell surface receptor signaling pathwayGO:0071669.4ERBB2, PRLR, PRL
11signal transductionGO:0071658.5HIF1A, FGF1, PGR, ERBB2, ESR1

Molecular functions related to Breast Fibroadenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein C-terminus bindingGO:0080228.7ERBB2, SYNJ2BP, VIM

Products for genes affiliated with Breast Fibroadenoma

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Sources for Breast Fibroadenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet