MCID: BRS053
MIFTS: 46

Breast Fibroadenoma malady

Categories: Genetic diseases, Cancer diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Breast Fibroadenoma

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Aliases & Descriptions for Breast Fibroadenoma:

Name: Breast Fibroadenoma 11 49 13
Fibroadenoma 11 49 38 67
Fibroadenoma of Breast 11 26 67
Juvenile Fibroadenoma of Breast 11 67
 
Complex Fibroadenoma of Breast 11
Juvenile Fibroadenoma 11
Cellular Fibroadenoma 11

Classifications:



Summaries for Breast Fibroadenoma

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Wikipedia:70 Fibroadenomas of the breast are benign tumors characterized by an admixture of stromal and epithelial... more...

MalaCards based summary: Breast Fibroadenoma, also known as fibroadenoma, is related to breast cancer and breast giant fibroadenoma. An important gene associated with Breast Fibroadenoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways is Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics. Affiliated tissues include breast, breast and testes, and related mouse phenotypes are digestive/alimentary and neoplasm.

Disease Ontology:11 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

Related Diseases for Breast Fibroadenoma

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Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer27.2CYP19A1, ERBB2, ESR1, KRT14, KRT8, NME1
2breast giant fibroadenoma11.1
3multiple fibroadenomas of the breast11.0
4breast pericanalicular fibroadenoma11.0
5ossifying fibromyxoid tumor10.7ERBB2, PGR
6cutaneous mucoepidermoid carcinoma10.7ERBB2, PGR
7her2-receptor negative breast cancer10.6ERBB2, PGR
8eyelid disease10.6ERBB2, ESR1
9animal phobia10.6ERBB2, PGR
10vaginal adenosarcoma10.6ERBB2, PGR
11simple partial epilepsy10.6MED12, PGR
12extragonadal nonseminomatous germ cell tumor10.6ERBB2, ESR1
13placenta disease10.6ERBB2, KRT8
14vulvar angiokeratoma10.6ESR1, PGR
15mollaret meningitis10.6CYP19A1, PGR
16central nervous system organ benign neoplasm10.6ESR1, PGR
17fallopian tube benign neoplasm10.6ESR1, PGR
18appendix leiomyoma10.6ESR1, PGR
19mixed cell adenoma10.6ESR1, PGR
20retinitis10.6ERBB2, PGR
21deafness, autosomal dominant 8/1210.6ESR1, PGR
22riedel's fibrosing thyroiditis10.6CYP19A1, ESR1
23perinatal intestinal perforation10.6ESR1, PGR
24bartholin's gland adenoid cystic carcinoma10.6ESR1, PGR
25gallbladder squamous cell carcinoma10.6ESR1, PGR
26amyloid tumor10.6ESR1, PGR
27extracranial neuroblastoma10.5ESR1, PGR
28malignant mediastinal neurogenic neoplasm10.5ESR1, PGR
29infiltrative basal cell carcinoma10.5ESR1, PGR
30fallopian tube germ cell cancer10.5ESR1, PGR
31apocrine adenocarcinoma10.5ERBB2, PGR
32bile duct mucoepidermoid carcinoma10.5ESR1, PGR
33hidradenoma10.5KRT15, KRT8
34breast malignant phyllodes tumor10.5ERBB2, ESR1
35pilar sheath acanthoma10.5ESR1, PGR
36gelatinous ascites10.4ERBB2, ESR1, PGR
37mast-cell sarcoma10.4ESR1, KRT8
38trigeminal nerve disease10.4ERBB2, ESR1, PGR
39glottis verrucous carcinoma10.4ERBB2, ESR1, PGR
40adenocarcinoma in situ10.4ERBB2, ESR1, PGR
41cholesteatoma of external ear10.4ERBB2, ESR1, PGR
42anomalous left coronary artery from the pulmonary artery10.4ERBB2, ESR1, PGR
43leiomyosarcoma10.4ERBB2, ESR1, PGR
44immune system cancer10.4ERBB2, ESR1, PGR
45gastric squamous cell carcinoma10.4ERBB2, KRT14
46progesterone-receptor negative breast cancer10.4ERBB2, ESR1, PGR
47mixed cerebral palsy10.4ERBB2, ESR1, PGR
48milker's nodule10.4ERBB2, ESR1, PGR
49lung carcinoma in situ10.4ERBB2, ESR1, PGR
50vulvar leiomyoma10.4ESR1, MED12, PGR

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to breast fibroadenoma

Symptoms for Breast Fibroadenoma

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Drugs & Therapeutics for Breast Fibroadenoma

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Drugs for Breast Fibroadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TamoxifenapprovedPhase 438010540-29-12733526
Synonyms:
(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene
(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(Para-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine
(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine (IUPAC)
(Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE
(Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
,citrate
1-P-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-Para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-.beta.-Dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
10540-29-1
1ya4
2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
54965-24-1 (citrate)
AC1MBZ3R
Apo-Tamox
Apo-tamox
BIDD:ER0008
BIDD:GT0009
BIDD:PXR0003
BPBio1_000278
BRD-K93754473-001-02-9
BRD-K93754473-048-05-3
BSPBio_000252
BSPBio_001150
BSPBio_001982
C07108
C26H29NO
CCRIS 3275
CHEBI:41774
CHEMBL83
CID2733526
Citofen
Crisafeno
D08559
DB00675
Diemon
EINECS 234-118-0
Gen-Tamoxifen
Gen-tamoxifen
HMS1362J11
HMS1792J11
HMS1990J11
HMS2090N08
HSDB 6782
ICI 47699
ICI-46,474
ICI-47699
IDI1_000258
IDI1_002170
Istubol
Kessar
L024126
LS-393
Lopac0_001203
MLS001332535
MLS001332536
MolPort-003-850-384
 
NCGC00024928-01
NCGC00024928-03
NCGC00024928-04
NCGC00024928-05
NCGC00024928-07
NCGC00024928-08
NCGC00024928-09
NCGC00024928-12
NSC727681
Noltam
Nolvadex
Nolvadex-D
Nourytam
Novaldex
Novo-Tamoxifen
Oncomox
PMS-Tamoxifen
Pms-Tamoxifen
Prestwick2_000146
Prestwick3_000146
QTL1_000079
Retaxim
SMR000059172
ST50511785
Spectrum5_001417
Spectrum5_002043
T5648_SIGMA
TAMOXIFEN (TAMOXIFEN CITRATE (54965-24-1))
TRANS FORM OF TAMOXIFEN
Tamizam
Tamofen
Tamone
Tamoplex (TN)
Tamoxasta
Tamoxen
Tamoxifen
Tamoxifen (INN)
Tamoxifen (TN)
Tamoxifen (Z)
Tamoxifen Citrate
Tamoxifen [INN:BAN]
Tamoxifen and its salts
Tamoxifene
Tamoxifene [INN-French]
Tamoxifeno
Tamoxifeno [INN-Spanish]
Tamoxifenum
Tamoxifenum [INN-Latin]
Tamoxifène
Tocris-0999
Tomaxithen
Trans-Tamoxifen
UNII-094ZI81Y45
UPCMLD-DP027
Valodex
Zemide
cMAP_000044
nchembio.140-comp7
nchembio.76-comp1
nchembio732-comp3
tamoxifen
trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine
trans-Tamoxifen
2HormonesPhase 413979
3Hormone AntagonistsPhase 412778
4AnalgesicsPhase 411287
5Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 412767
6Lipid Regulating AgentsPhase 42702
7Selective Estrogen Receptor ModulatorsPhase 4586
8Peripheral Nervous System AgentsPhase 422776
9Estrogen Receptor ModulatorsPhase 4630
10Hypolipidemic AgentsPhase 42721
11EstrogensPhase 42470
12Estrogen AntagonistsPhase 41315
13Anti-Inflammatory Agents, Non-SteroidalPhase 44295
14Anti-Inflammatory AgentsPhase 410355
15Analgesics, Non-NarcoticPhase 46260
16Antineoplastic Agents, HormonalPhase 45407
17AntimetabolitesPhase 411774
18Antirheumatic AgentsPhase 410627
19Dermatologic AgentsPhase 45674
20EfamolPhase 416
21Bone Density Conservation AgentsPhase 43266
22Evening PrimroseNutraceuticalPhase 46
23Pharmaceutical Solutions7793
24Immunoglobulins6045
25Autoantibodies126
26Antibodies6045

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast CancerCompletedNCT00999921Phase 4
2Feasibility Study Assessing the Treatment of Fibroadenomata With a Circumferential Sonication Treatment With HIFUActive, not recruitingNCT02139683Phase 3
3Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)Active, not recruitingNCT02011919Phase 2, Phase 3
4MR Guided Focused Ultrasound Surgery in the Treatment of Breast FibroadenomasTerminatedNCT00147108Phase 3
5Treatment of Breast Fibroadenoma With FastScan HIFURecruitingNCT02488655Phase 1
6Optical Tomography With Ultrasound GuidanceUnknown statusNCT00908609
7High Intensity Focused Ultrasound (HIFU) to Treat Breast FibroadenomaCompletedNCT01422629
8Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)CompletedNCT03022695
9ICE-SENSE™ Cryotherapy for Breast Fibroadenoma TrialCompletedNCT00910312
10American Breast Laser Ablation Therapy EvaluationRecruitingNCT00807924
11Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 LesionsRecruitingNCT02638935
12Treatment of Breast Fibroadenoma With High Intensity Focused UltrasoundActive, not recruitingNCT02078011
13Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)Active, not recruitingNCT01331954
14LOUIS-3D Breast StudyActive, not recruitingNCT01755130
15Synthetic Aperture Radar Detection of Breast TumoursEnrolling by invitationNCT02493595
16Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood TestNot yet recruitingNCT02066025

Search NIH Clinical Center for Breast Fibroadenoma


Cochrane evidence based reviews: fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Genetic tests related to Breast Fibroadenoma:

id Genetic test Affiliating Genes
1 Fibroadenoma of the Breast26

Anatomical Context for Breast Fibroadenoma

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MalaCards organs/tissues related to Breast Fibroadenoma:

35
Breast, Testes, Bone, Lung

FMA organs/tissues related to Breast Fibroadenoma:

17
Breast

Animal Models for Breast Fibroadenoma or affiliated genes

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MGI Mouse Phenotypes related to Breast Fibroadenoma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1CYP19A1, ERBB2, ESR1, KRT14, KRT8, NGFR
2MP:00020069.1ERBB2, ESR1, KRT14, NME1, PGR, RASSF1
3MP:00053798.8CYP19A1, ERBB2, ESR1, KRT14, NME1, PGR
4MP:00053858.7CYP19A1, ERBB2, ESR1, KRT8, MED12, NGFR
5MP:00028738.2CYP19A1, ERBB2, ESR1, MED12, NGFR, PGR
6MP:00053708.0CYP19A1, ESR1, KRT8, MME, NGFR, NME1
7MP:00053877.9CYP19A1, ESR1, KRT14, KRT8, MME, NGFR
8MP:00107717.8CYP19A1, ERBB2, ESR1, KRT14, MME, NGFR

Publications for Breast Fibroadenoma

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Articles related to Breast Fibroadenoma:

(show top 50)    (show all 59)
idTitleAuthorsYear
1
Multimodality approach in the diagnosis and management of bilateral giant juvenile breast fibroadenoma. (27758851)
2016
2
Invasive Ductal Carcinoma Displayed "Basal-Like" Feature Arising within a Breast Fibroadenoma. (27870335)
2016
3
Ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma-a multicenter experience. (25635224)
2015
4
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. (25038752)
2014
5
Ultrasound-guided cryoablation of breast fibroadenoma: a pilot trial. (25408274)
2014
6
Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)
2013
7
Fine-needle aspiration of gray zone lesions of the breast: fibroadenoma versus ductal carcinoma. (22936545)
2013
8
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
9
Transaxillary approach with use of traction suture for excision of breast fibroadenoma: a new technique and its results. (22604577)
2012
10
A clinical study on the resection of breast fibroadenoma using two types of incision. (22108740)
2011
11
Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. (21733035)
2011
12
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)
2011
13
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. (22011321)
2011
14
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue. (22249796)
2011
15
Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. (21192183)
2011
16
Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. (21875284)
2011
17
Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. (24376952)
2010
18
Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (19897676)
2010
19
Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women. (21039041)
2010
20
Recurrence of giant juvenile breast fibroadenoma in a girl with Turner's syndrome. (19492586)
2009
21
Ectopic breast fibroadenoma of the vulva. (19622961)
2009
22
Herb-related aneuploidy in breast fibroadenoma. (21686556)
2009
23
A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. (19211906)
2009
24
Invasive mucinous carcinoma arising within breast fibroadenoma. (18841829)
2008
25
Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)
2008
26
Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. (18094894)
2007
27
Breast fibroadenoma in female adolescents. (17206308)
2007
28
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. (16961651)
2006
29
p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. (15578730)
2005
30
Malignant transformation of a breast fibroadenoma to cystosarcoma phyllodes: case report and review of the literature. (15943412)
2005
31
Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. (16297109)
2005
32
Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. (16405127)
2005
33
Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. (15450823)
2004
34
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
35
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)
2001
36
Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. (10432878)
1999
37
Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. (9885614)
1999
38
Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells. (10349403)
1999
39
Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. (9278103)
1997
40
Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)
1997
41
Breast fibroadenoma with atypical features: a case report. (8629423)
1996
42
Infarction of breast fibroadenoma in a postmenopausal woman. (8044310)
1994
43
Possibilities of the conventional and interventional sonography in diagnosis of breast fibroadenoma. (1841055)
1991
44
Risk factors for breast fibroadenoma in young women. (2766721)
1989
45
Carcinoma in a breast fibroadenoma. (3473866)
1987
46
Morphometry of the breast fibroadenoma. (3562341)
1986
47
A radiodiagnostic study of breast fibroadenoma. (2949499)
1985
48
Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells. (6164351)
1980
49
Breast fibroadenoma and cardiac anomaly associated with EMG (Beckwith-Wiedemann) syndrome. (430311)
1979
50
The myoepithelium in human breast fibroadenoma. (4452932)
1974

Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

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Pathways related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9CYP19A1, ESR1

GO Terms for genes affiliated with Breast Fibroadenoma

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Cellular components related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058828.9KRT14, KRT15, KRT8, NME1

Biological processes related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intracellular steroid hormone receptor signaling pathwayGO:003051810.3ESR1, MED12
2androgen metabolic processGO:000820910.0CYP19A1, ESR1
3transcription initiation from RNA polymerase II promoterGO:00063679.9ESR1, MED12, PGR
4negative regulation of gene expressionGO:00106299.4ESR1, NME1, PGR
5positive regulation of epithelial cell proliferationGO:00506799.1ERBB2, ESR1, NME1

Molecular functions related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.1ESR1, HMGA2, NME1, PGR

Sources for Breast Fibroadenoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet