MCID: BRS053
MIFTS: 54

Breast Fibroadenoma malady

Genetic diseases, Cancer diseases, Reproductive diseases, Rare diseases categories
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Summaries for Breast Fibroadenoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Fibroadenomas of the breast are lumps composed of fibrous and glandular tissue. Because breast cancer... more...

MalaCards: Breast Fibroadenoma, also known as fibroadenoma, is related to ductal carcinoma in situ and adenoma. An important gene associated with Breast Fibroadenoma is HIF1A (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)), and among its related pathways are Signaling by FGFR1 mutants and FGF signaling pathway. The compounds fadrozole and idoxifene have been mentioned in the context of this disorder. Affiliated tissues include breast and lung, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Aliases & Classifications for Breast Fibroadenoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:



Aliases & Descriptions:

breast fibroadenoma 8 10 45
fibroadenoma 8 45 62
juvenile fibroadenoma of breast 8 62
fibroadenoma of breast 8 62
complex fibroadenoma of the breast 8
fibroadenoma, no icd-o subtype 8
complex fibroadenoma of breast 8
juvenile fibroadenoma 8
cellular fibroadenoma 8
fibroadenoma nos 8


Related Diseases for Breast Fibroadenoma

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17GeneCards, 18GeneDecks
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Diseases in the Multiple Fibroadenomas of the Breast family:

breast fibroadenoma

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1ductal carcinoma in situ30.2PGR, ESR1, ERBB2
2adenoma30.2PRLR, FGFR4, FGF1, PRL
3myoma30.2CYP19A1, PGR, ESR1
4li-fraumeni syndrome30.1ERBB2, ESR1, PGR
5breast cancer29.9CYP19A1, ERBB2, HIF1A, PGR, ESR1, FGF1
6gynecomastia29.8ESR1, CYP19A1, PGR, PRL
7multiple fibroadenomas of the breast10.3
8phyllode tumor10.3
9pseudoangiomatous stromal hyperplasia10.2
10neurofibromatosis10.2
11breast giant fibroadenoma10.2
12breast pericanalicular fibroadenoma10.2
13chickenpox10.2
14fibromatosis10.2
15transsexualism10.1
16fibroma10.1
17beckwith-wiedemann syndrome10.1
18hodgkin's lymphoma10.1
19medulloblastoma10.1
20breast intracanalicular fibroadenoma10.1
21breast fibroadenosis10.1
22gigantomastia10.1
23pituitary carcinoma10.1PRL
24myocardial infarction10.1HIF1A, FGF1
25endocrine gland cancer10.1ESR1, CYP19A1
26cerebral meningioma10.1PGR, PRLR
27uterine sarcoma10.1CYP19A1, ESR1
28estrogen excess10.0PGR, CYP19A1
29pleomorphic adenoma10.0FGF1, ERBB2
30sertoli cell tumor10.0CYP19A1, PGR
31abrikosov's tumor10.0CYP19A1, ESR1
32cribriform carcinoma10.0ESR1, PGR
33osteoporosis, postmenopausal10.0CYP19A1, ESR1
34progesterone resistance10.0PGR, ESR1
35bilateral breast cancer10.0ESR1, PGR
36leiomyomatosis10.0PGR, ESR1
37adenosarcoma10.0PGR, ESR1
38uterine fibroid10.0PGR, ESR1
39gastric adenocarcinoma10.0FGF1, HIF1A, ERBB2
40lymphangioleiomyomatosis10.0PGR, ESR1
41angiomyolipoma10.0PGR, ESR1
42squamous cell carcinoma of the head and neck10.0HIF1A, FGFR4, ERBB2
43malignant mixed mullerian tumor10.0ERBB2, PGR
44cervical adenocarcinoma10.0PGR, ESR1
45lung adenocarcinoma10.0HIF1A, ERBB2, FGFR4
46vascular disease10.0ESR1, HIF1A, FGF1
47smooth muscle tumor10.0ESR1, PGR
48hypogonadism, hypergonadotropic10.0CYP19A1, PRL
49ovarian disease10.0PRL, CYP19A1
50anovulation10.0PRL, CYP19A1

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to breast fibroadenoma

Symptoms for Breast Fibroadenoma

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Drugs & Therapeutics for Breast Fibroadenoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Breast Fibroadenoma

Search NIH Clinical Center for Breast Fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Anatomical Context for Breast Fibroadenoma

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33MalaCards
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MalaCards organs/tissues related to Breast Fibroadenoma:

33
Breast, Lung

Animal Models for Breast Fibroadenoma or affiliated genes

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37MGI
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Publications for Breast Fibroadenoma

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52PubMed
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Articles related to Breast Fibroadenoma:

(show all 50)
idTitleAuthorsYear
1
Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)
2013
2
Fine-needle aspiration of gray zone lesions of the breast: fibroadenoma versus ductal carcinoma. (22936545)
2013
3
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
4
Transaxillary approach with use of traction suture for excision of breast fibroadenoma: a new technique and its results. (22604577)
2012
5
A clinical study on the resection of breast fibroadenoma using two types of incision. (22108740)
2011
6
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. (22011321)
2011
7
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue. (22249796)
2011
8
Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. (21733035)
2011
9
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)
2011
10
Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. (21192183)
2011
11
Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. (21875284)
2011
12
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. (22121516)
2011
13
Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. (24376952)
2010
14
Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (19897676)
2010
15
Comparison of telomere length and telomerase activation between breast fibroadenoma and infiltrating ductal carcinoma in Malaysian women. (21039041)
2010
16
A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. (19211906)
2009
17
Recurrence of giant juvenile breast fibroadenoma in a girl with Turner's syndrome. (19492586)
2009
18
Ectopic breast fibroadenoma of the vulva. (19622961)
2009
19
Herb-related aneuploidy in breast fibroadenoma. (21686556)
2009
20
Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)
2008
21
Invasive mucinous carcinoma arising within breast fibroadenoma. (18841829)
2008
22
Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. (18094894)
2007
23
Breast fibroadenoma in female adolescents. (17206308)
2007
24
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. (16961651)
2006
25
Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. (16297109)
2005
26
Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. (16405127)
2005
27
p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. (15578730)
2005
28
Malignant transformation of a breast fibroadenoma to cystosarcoma phyllodes: case report and review of the literature. (15943412)
2005
29
Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. (15450823)
2004
30
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
31
Breast fibroadenoma in teenage females. (14768798)
2003
32
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)
2001
33
Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. (10432878)
1999
34
Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells. (10349403)
1999
35
Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. (9885614)
1999
36
Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. (9278103)
1997
37
Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)
1997
38
Breast fibroadenoma with atypical features: a case report. (8629423)
1996
39
Infarction of breast fibroadenoma in a postmenopausal woman. (8044310)
1994
40
Aspiration cytology of breast fibroadenoma with atypia. (1606889)
1992
41
Medulloblastoma metastasizing to a breast fibroadenoma: a case report. (2021436)
1991
42
Risk factors for breast fibroadenoma in young women. (2766721)
1989
43
Carcinoma in a breast fibroadenoma. (3473866)
1987
44
Estrogen receptor in dissociated and cultured human breast fibroadenoma epithelial cells. (3828977)
1987
45
Morphometry of the breast fibroadenoma. (3562341)
1986
46
Management of breast fibroadenoma in women under 25 years of age. (3730963)
1986
47
A radiodiagnostic study of breast fibroadenoma. (2949499)
1985
48
Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells. (6164351)
1980
49
Breast fibroadenoma and cardiac anomaly associated with EMG (Beckwith-Wiedemann) syndrome. (430311)
1979
50
The myoepithelium in human breast fibroadenoma. (4452932)
1974

Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Fibroadenoma

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Pathways for genes affiliated with Breast Fibroadenoma

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 51PharmGKB, 5Cell Signaling Technology, 30KEGG, 60Thomson Reuters
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Pathways related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8FGFR4, FGF1
29.8FGFR4, FGF1
39.6FGFR4, ERBB2
4
Show member pathways
9.5ESR1, CYP19A1
5
Show member pathways
9.5FGFR4, FGF1, HIF1A
69.5FGFR4, FGF1, HIF1A
7
Show member pathways
Nuclear Receptors38
9.3ESR1, PGR
89.3HIF1A, ERBB2, FGF1
99.2PRL, PRLR
109.2PRL, PRLR
11
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.2HIF1A, ESR1, PRLR
12
Show member pathways
9.2FGFR4, FGF1, ERBB2
13
Show member pathways
9.2FGFR4, FGF1, ERBB2
14
Show member pathways
9.2ERBB2, FGF1, FGFR4
159.2FGFR4, FGF1, ERBB2
169.1ESR1, ERBB2, FGF1
179.0CYP19A1, PGR, PRLR
188.8FGF1, ERBB2, ESR1, HIF1A
198.7PRL, PRLR, ERBB2
20
Show member pathways
8.7FGFR4, FGF1, ERBB2, ESR1
21
Show member pathways
8.7ESR1, ERBB2, FGF1, FGFR4
228.5PRL, PRLR, FGF1, FGFR4
23
Show member pathways
8.4HIF1A, ESR1, ERBB2, FGF1, FGFR4
24
Show member pathways
8.4FGFR4, ERBB2, PRLR, PRL
25
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
8.2ERBB2, PRLR, PRL, ESR1
268.1HIF1A, PRL, ERBB2, FGF1, FGFR4
27
Show member pathways
8.1PGR, ESR1, PRL, PRLR
28
Show member pathways
8.0PRL, PRLR, ERBB2, FGF1, FGFR4
29
Show member pathways
8.0PRL, PRLR, ERBB2, FGF1, FGFR4
30
Show member pathways
6.9FGFR4, FGF1, ERBB2, PRLR, PRL, ESR1
31
Show member pathways
6.6HIF1A, PGR, ESR1, PRL, PRLR, ERBB2

Compounds for genes affiliated with Breast Fibroadenoma

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45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 128)
idCompoundScoreTop Affiliating Genes
1fadrozole459.2ESR1, ERBB2, CYP19A1
2idoxifene459.2ESR1, PGR, CYP19A1
3nandrolone45 249.9PGR, ESR1, CYP19A1
4tibolone458.9CYP19A1, PGR, ESR1, ARSH
5steroidal458.8ARSH, PGR, CYP19A1, ESR1
6goserelin45 29 1110.8PGR, ESR1, CYP19A1
7megestrol acetate458.8ERBB2, PGR, CYP19A1, ESR1
817beta-hydroxysteroid458.8CYP19A1, ARSH, PGR, ESR1
9exemestane45 51 61 1111.7CYP19A1, ESR1, PGR, ERBB2
10anastrozole45 51 1110.7CYP19A1, PGR, ERBB2, ESR1
11lapatinib45 51 1110.7ERBB2, CYP19A1, ESR1, PGR
12nomegestrol acetate458.7PGR, ESR1, ARSH
13fulvestrant45 51 29 1111.7ERBB2, PGR, CYP19A1, ESR1
14bisphenol a458.7ARSH, PGR, HIF1A, CYP19A1, ESR1
15letrozole45 51 61 1111.7CYP19A1, PGR, ESR1, ERBB2
16taxane458.7CYP19A1, PGR, ESR1, ERBB2
17progestins458.6ARSH, PRLR, CYP19A1, PGR, ESR1
18raloxifene45 51 29 1111.5ERBB2, ESR1, CYP19A1, PGR
19geldanamycin45 51 61 1111.5FGF1, ERBB2, ESR1, HIF1A, PGR
20estradiol benzoate458.5CYP19A1, PGR, PRL, ESR1
21trastuzumab45 51 1110.5HIF1A, CYP19A1, PGR, ESR1, ERBB2
22leuprolide acetate458.5ESR1, PRL, CYP19A1, PGR
234-hydroxytamoxifen458.4PGR, CYP19A1, ESR1, ERBB2, ARSH
24clomiphene citrate458.4PGR, CYP19A1, ESR1, PRL
25levonorgestrel45 61 29 1111.4CYP19A1, PGR, PRL, ESR1
26docetaxel45 51 61 1111.3ERBB2, ESR1, PGR, HIF1A, CYP19A1
27flutamide45 61 1110.3PGR, ESR1, PRL, CYP19A1
28cyclophosphamide45 51 1110.3ERBB2, ESR1, PGR, HIF1A, CYP19A1
29methotrexate51 45 1110.2ERBB2, CYP19A1, ESR1, HIF1A, PGR
30danazol45 24 1110.2PRL, CYP19A1, PGR, ARSH, ESR1
315fluorouracil458.2ESR1, ERBB2, PGR, CYP19A1, HIF1A
32estrone sulfate45 249.2ARSH, PRL, ESR1, PGR, CYP19A1
33estrone45 29 24 1111.1PGR, PRL, CYP19A1, ARSH, ESR1
34paclitaxel45 51 1110.1HIF1A, PGR, CYP19A1, ESR1, ERBB2
35toremifene45 119.0ERBB2, ESR1, PGR, CYP19A1, PRL
36dihydrotestosterone45 29 24 1110.9ESR1, HIF1A, ARSH, PRL, PGR, CYP19A1
37paraffin457.8PRLR, FGFR4, FGF1, ERBB2, ESR1, PGR
38vegf457.8FGFR4, HIF1A, FGF1, ERBB2, ESR1, PGR
39genistein45 29 61 3 24 1112.7PGR, PRLR, HIF1A, CYP19A1, ERBB2, FGF1
40cycloheximide457.7PRLR, FGF1, ERBB2, CYP19A1, HIF1A, ESR1
41arginine457.6FGF1, ARSH, CYP19A1, HIF1A, PRL, ERBB2
42estradiol45 24 119.6ARSH, ESR1, CYP19A1, PGR, PRLR, PRL
43dexamethasone45 51 29 1110.3PRL, PGR, CYP19A1, HIF1A, PRLR, ERBB2
44progestin457.3ESR1, CYP19A1, PGR, ARSH, ERBB2, PRLR
45gnrh457.2ERBB2, PRLR, ARSH, CYP19A1, PGR, ESR1
46progesterone45 29 61 24 1111.2ARSH, ERBB2, PRL, PRLR, CYP19A1, ESR1
47steroid457.2CYP19A1, PGR, ESR1, PRL, ARSH, ERBB2
48tamoxifen45 51 29 119.6PRL, ERBB2, ARSH, FGF1, ESR1, HIF1A
49testosterone45 61 24 119.6CYP19A1, ARSH, HIF1A, PGR, ESR1, PRL
50estrogen456.6ESR1, PRL, PGR, PRLR, ERBB2, ARSH

GO Terms for genes affiliated with Breast Fibroadenoma

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16Gene Ontology
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Biological processes related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1organ inductionGO:00175910.0FGFR4, FGF1
2positive regulation of nitric-oxide synthase activityGO:0510009.9ESR1, HIF1A
3androgen metabolic processGO:0082099.7CYP19A1, ESR1
4steroid biosynthetic processGO:0066949.6PRLR, CYP19A1
5positive regulation of epithelial cell proliferationGO:0506799.6FGF1, ERBB2
6phosphatidylinositol-mediated signalingGO:0480159.5ERBB2, FGF1, FGFR4
7fibroblast growth factor receptor signaling pathwayGO:0085439.4FGFR4, FGF1, ERBB2
8Fc-epsilon receptor signaling pathwayGO:0380959.3FGFR4, FGF1, ERBB2
9epidermal growth factor receptor signaling pathwayGO:0071739.3ERBB2, FGF1, FGFR4
10lactationGO:0075959.2PRLR, PRL, HIF1A
11JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.1PRLR, PRL
12neurotrophin TRK receptor signaling pathwayGO:0480118.9ERBB2, FGF1, FGFR4
13cell surface receptor signaling pathwayGO:0071668.9ERBB2, PRLR, PRL
14signal transductionGO:0071658.4FGF1, ERBB2, ESR1, PGR, HIF1A

Molecular functions related to Breast Fibroadenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.3ESR1, PGR
2steroid hormone receptor activityGO:0037079.0ESR1, PGR
3enzyme bindingGO:0198998.9HIF1A, PGR, ESR1
4protein bindingGO:0055156.9PRLR, ERBB2, ESR1, PGR, HIF1A, FGF1

Products for genes affiliated with Breast Fibroadenoma

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Sources for Breast Fibroadenoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet