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MCID: BRS053
MIFTS: 46

Breast Fibroadenoma malady
13 genes, 124 related diseases, clinical trials.

Summaries for Breast Fibroadenoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 Fibroadenomas of the breast are lumps composed of fibrous and glandular tissue. Because breast cancer... more...

MalaCards: Breast Fibroadenoma, also known as fibroadenoma, is related to phyllode tumor and fibromatosis. An important gene associated with Breast Fibroadenoma is HIF1A (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)), and among its related pathways are Nanog in Mammalian ESC Pluripotency and Angiogenesis. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Breast Fibroadenoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

breast fibroadenoma 8 10 45
fibroadenoma 8 45 61
juvenile fibroadenoma of breast 8 61
fibroadenoma of breast 8 61
complex fibroadenoma of the breast 8
fibroadenoma, no icd-o subtype 8
complex fibroadenoma of breast 8
juvenile fibroadenoma 8
cellular fibroadenoma 8
fibroadenoma nos 8


Related Diseases for Breast Fibroadenoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Breast Fibroadenoma family:

multiple fibroadenomas of the breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1phyllode tumor30.3VIM, PGR
2fibromatosis30.2PGR, VIM
3adenoma30.2FGF1, PRLR, PRL, FGFR4
4myoma30.1CYP19A1, PGR, ESR1
5angiosarcoma29.8VIM
6ductal carcinoma in situ29.8ERBB2, PGR, ESR1
7gynecomastia29.8ESR1, PGR, CYP19A1, PRL
8li-fraumeni syndrome29.8PGR, CYP19A1, ESR1, ERBB2, PRLR
9breast giant fibroadenoma10.3
10multiple fibroadenomas of the breast10.3
11breast malignant phyllodes tumor10.3
12breast pericanalicular fibroadenoma10.2
13chickenpox10.2
14neurofibromatosis10.1
15androgen insensitivity syndrome10.1
16granular cell tumor10.1
17breast granular cell tumor10.1
18complete androgen insensitivity syndrome10.1
19gigantomastia10.1
20pseudoangiomatous stromal hyperplasia10.1
21hemihypertrophy10.1
22beckwith-wiedemann syndrome10.1
23breast lymphoma10.1
24lobular neoplasia10.1
25turner syndrome10.1
26breast intracanalicular fibroadenoma10.1
27breast fibroadenosis10.1
28obesity10.0HIF1A
29arthritis10.0FGF1
30tongue cancer10.0PRLR
31rheumatoid arthritis10.0PRLR
32alzheimer's disease10.0FGF1
33leydig cell tumor10.0CYP19A1
34osteoarthritis10.0FGF1
35lung cancer10.0ERBB2
36neuroendocrine tumor10.0PRL
37uterine carcinosarcoma10.0ERBB2
38craniopharyngioma10.0PRL
39aromatase deficiency10.0CYP19A1
40cervical cancer10.0HIF1A
41pheochromocytoma10.0HIF1A, FGF1
42sertoli-leydig cell tumor10.0PGR
43malignant glioma10.0HIF1A
44cushing's syndrome10.0PRL
45gastrointestinal stromal tumor10.0VIM
46chordoma10.0VIM
47hyperprolactinemia10.0PRL, PRLR
48rhabdomyosarcoma10.0VIM
49schizophrenia10.0PRL
50hypogonadism, hypergonadotropic10.0PRL, CYP19A1

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to breast fibroadenoma

Clinical Features for Breast Fibroadenoma

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Drugs & Therapeutics for Breast Fibroadenoma

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Breast Fibroadenoma

Drug clinical trials:

Search ClinicalTrials for Breast Fibroadenoma

Search NIH Clinical Center for Breast Fibroadenoma

Search CenterWatch for Breast Fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Anatomical Context for Breast Fibroadenoma

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Animal Models for Breast Fibroadenoma or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Breast Fibroadenoma:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
endocrine/exocrine gland phenotype
MP:000537910.3PRLR
2
integument phenotype
MP:001077110.1PRLR, HIF1A
3
reproductive system phenotype
MP:00053899.6PRL, ERBB2, PRLR
4
muscle phenotype
MP:00053699.2CYP19A1, ESR1, HIF1A
5
homeostasis/metabolism phenotype
MP:00053768.3FGFR4, FGF1, PRLR, PGR, ESR1, PRL
6
skeleton phenotype
MP:00053908.1ESR1, ERBB2, PGR, CYP19A1, HIF1A, PRLR
7
tumorigenesis
MP:00020068.0PGR, PRLR, PRL, HIF1A, FGFR4, ESR1
8
embryogenesis phenotype
MP:00053807.6ESR1, ERBB2, PGR, HIF1A, PRLR, VIM
9
nervous system phenotype
MP:00036317.3ESR1, HIF1A, PRLR, FGF1, VIM, PRL
10
behavior/neurological phenotype
MP:00053867.2ESR1, ERBB2, PGR, CYP19A1, HIF1A, PRLR
11
cellular phenotype
MP:00053847.0HIF1A, PRLR, ERBB2, ESR1, VIM, PGR

Publications for Breast Fibroadenoma

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51PubMed
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Articles related to Breast Fibroadenoma:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)
2013
2
A clinical study on the resection of breast fibroadenoma using two types of incision. (22108740)
2011
3
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. (22011321)
2011
4
Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. (21733035)
2011
5
Human sodium iodide symporter (hNIS) in fibroadenoma breast--a immunohistochemical study. (21428212)
2011
6
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)
2011
7
Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. (24376952)
2010
8
Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (19897676)
2010
9
Intraductal fibroadenoma and intraductal phyllodes tumour--a part of the spectrum of the breast ductal adenoma? (20013344)
2010
10
A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. (19211906)
2009
11
A rare coexistence of concurrent breast hemangioma with fibroadenoma: a case report. (19829893)
2009
12
Ectopic breast fibroadenoma of the vulva. (19622961)
2009
13
Progesterone receptors A and B and estrogen receptor alpha expression in normal breast tissue and fibroadenomas. (19367380)
2009
14
RHEB expression in fibroadenomas of the breast. (18324915)
2008
15
Invasive mucinous carcinoma arising within breast fibroadenoma. (18841829)
2008
16
Morphologic changes in fibroadenoma of breast due to chickenpox: a case report with suspicious cytology in fine needle aspiration smears. (18540301)
2008
17
Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. (18094894)
2007
18
Breast fibroadenoma in female adolescents. (17206308)
2007
19
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. (16961651)
2006
20
Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. (16297109)
2005
21
Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. (16405127)
2005
22
Estrogen receptor-alpha, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast: association with nodule size, hormonal and reproductive features. (15763593)
2005
23
Association of viral factors with non-familial breast cancer in Taiwan by comparison with non-cancerous, fibroadenoma, and thyroid tumor tissues. (15602723)
2005
24
Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. (15450823)
2004
25
Augmented release of matrix metalloproteinase-9 by PKC activation in organotypic cultures of human breast cancer and adjacent normal breast tissue and fibroadenoma. (15481789)
2004
26
Metaphase and interphase cytogenetics in fibroadenomas of the breast. (15646810)
2004
27
Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women. (15241822)
2004
28
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
29
Expression of CD34 and bcl-2 in phyllodes tumours, fibroadenomas and spindle cell lesions of the breast. (11135048)
2001
30
A 19 year old with complete androgen insensitivity syndrome and juvenile fibroadenoma of the breast. (11843857)
2001
31
Absence of genetic abnormalities in fibroadenomas of the breast determined at p53 gene mutations and microsatellite alterations. (11691818)
2001
32
Platelet-derived growth factor expression in phyllodes tumors and fibroadenomas of the breast. (11070114)
2000
33
Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. (10432878)
1999
34
Alteration of hMSH2 and DNA polymerase beta genes in breast carcinomas and fibroadenomas. (10362525)
1999
35
Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. (9885614)
1999
36
A comparison of the pattern of cathepsin-D expression in fibroadenoma, fibrocystic disease, preinvasive and invasive ductal breast carcinoma. (10503271)
1999
37
Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. (9278103)
1997
38
Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)
1997
39
Breast fibroadenoma with atypical features: a case report. (8629423)
1996
40
Infarction of breast fibroadenoma in a postmenopausal woman. (8044310)
1994
41
Medulloblastoma metastasizing to a breast fibroadenoma: a case report. (2021436)
1991
42
Possibilities of the conventional and interventional sonography in diagnosis of breast fibroadenoma. (1841055)
1991
43
Risk factors for breast fibroadenoma in young women. (2766721)
1989
44
Carcinoma in a breast fibroadenoma. (3473866)
1987
45
Management of breast fibroadenoma in women under 25 years of age. (3730963)
1986
46
A radiodiagnostic study of breast fibroadenoma. (2949499)
1985
47
Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells. (6164351)
1980
48
Breast fibroadenoma and cardiac anomaly associated with EMG (Beckwith-Wiedemann) syndrome. (430311)
1979
49
The myoepithelium in human breast fibroadenoma. (4452932)
1974
50
Bilateral fibroadenoma in supernumerary breasts of the vulva. (5775152)
1969

Genetic Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Fibroadenoma

Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

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Sources:
52QIAGEN, 4Cell Signaling Technology, 54Reactome, 50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
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Pathways related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Nanog in Mammalian ESC Pluripotency52
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9.7FGFR4, VIM
2
Angiogenesis4
9.6HIF1A, FGFR4, FGF1
3
Estrogen biosynthesis54
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9.5ESR1, CYP19A1
4
Tyrosine Kinases / Adaptors4
9.5ERBB2, FGF1, FGFR4
5
Ca-dependent events54
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9.5ERBB2, FGF1, FGFR4
6
ErbB4 signaling events38
9.4PRL, PRLR, ERBB2
7
Ovarian Infertility Genes38
9.4PRLR, CYP19A1, PGR
8
Prolactin receptor signaling54
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9.3PRL, PRLR, PGR
9
Development Ligand-dependent activation of the ESR1/AP-1 pathway
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9.3ESR1, HIF1A, PRLR
10
PI3K-Akt signaling pathway30
9.2PRL, PRLR, FGFR4, FGF1
11
Proteoglycans in cancer30
8.9HIF1A, FGF1, ERBB2, ESR1
12
Disease54
8.9ERBB2, FGF1, FGFR4, HIF1A, PRL
13
TGF-Beta Pathway52
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8.8ERBB2, FGF1, FGFR4, PRLR, PRL
14
Development Prolactin receptor signaling
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8.7ESR1, ERBB2, PRLR, PRL
15
Rho Family GTPases52
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8.1VIM, HIF1A, FGFR4, FGF1, ERBB2, ESR1
16
PIP3 activates AKT signaling54
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7.7ESR1, PRL, PRLR, FGFR4, FGF1, PGR
17
Signaling by GPCR54
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7.5PRL, PRLR, HIF1A, FGFR4, FGF1, PGR

Compounds for genes affiliated with Breast Fibroadenoma

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Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6ARSH
2dexamethasone45 50 29 1113.0PRLR, HIF1A, FGF1
3idoxifene459.4CYP19A1, PGR, ESR1
45fluorouracil459.4PGR, HIF1A, ERBB2
5fadrozole459.3CYP19A1, ERBB2, ESR1
6danazol45 11 2411.2ESR1, ARSH, PGR, CYP19A1
7tibolone459.1ARSH, ESR1, PGR, CYP19A1
8gnrh459.1CYP19A1, ERBB2, ARSH, PRLR, PGR
9estradiol benzoate459.1ESR1, PGR, CYP19A1, PRL
10leuprolide acetate459.1PRL, ESR1, PGR, CYP19A1
11megestrol acetate459.0CYP19A1, ESR1, ERBB2, PGR
12clomiphene citrate459.0PGR, CYP19A1, PRL, ESR1
13steroidal459.0PGR, ESR1, ARSH, CYP19A1
14anastrozole45 1110.0ESR1, ERBB2, PGR, CYP19A1
15exemestane50 45 60 1112.0CYP19A1, PGR, ERBB2, ESR1
16lapatinib45 50 1111.0ESR1, PGR, CYP19A1, ERBB2
17levonorgestrel45 60 29 1112.0ESR1, PGR, CYP19A1, PRL
18fulvestrant45 50 29 1112.0CYP19A1, PGR, ESR1, ERBB2
19taxane459.0ERBB2, PGR, CYP19A1, ESR1
20flutamide45 60 1111.0PRL, ESR1, PGR, CYP19A1
21bisphenol a459.0PGR, ARSH, HIF1A, CYP19A1, ESR1
22letrozole45 50 60 1112.0ESR1, CYP19A1, ERBB2, PGR
23progestins458.9ESR1, CYP19A1, PGR, PRLR, ARSH
2417beta-hydroxysteroid458.9PGR, CYP19A1, ESR1, ARSH
25estrone sulfate45 249.8PGR, ARSH, PRL, CYP19A1, ESR1
26hydrocortisone45 2 60 1111.8FGF1, ERBB2, CYP19A1, PRL, VIM
27trastuzumab45 50 1110.8HIF1A, CYP19A1, PGR, ERBB2, ESR1
28geldanamycin45 50 60 1111.8ESR1, ERBB2, PGR, FGF1, HIF1A
29nandrolone45 249.8ESR1, CYP19A1, PGR
30estrone45 29 11 2411.7PRL, CYP19A1, PGR, ESR1, ARSH
31toremifene45 119.7ESR1, ERBB2, PGR, CYP19A1, PRL
32n-(4-hydroxyphenyl)retinamide458.7CYP19A1, ESR1, ERBB2, VIM
33paclitaxel45 50 1110.7CYP19A1, PGR, ERBB2, ESR1, HIF1A
34docetaxel45 50 60 1111.6CYP19A1, ERBB2, HIF1A, PGR, ESR1
35raloxifene45 29 50 1111.5ERBB2, CYP19A1, PGR, ESR1
36cyclophosphamide45 50 1110.5ERBB2, HIF1A, PGR, CYP19A1, ESR1
37steroid458.3ARSH, PRLR, PRL, CYP19A1, ESR1, ERBB2
384-hydroxytamoxifen458.3ESR1, VIM, ARSH, CYP19A1, PGR, ERBB2
39methotrexate45 50 1110.2ESR1, ERBB2, PGR, CYP19A1, HIF1A, VIM
40arginine458.1CYP19A1, FGFR4, ERBB2, HIF1A, PRL, FGF1
41dihydrotestosterone45 29 11 2411.1PGR, CYP19A1, HIF1A, PRL, VIM, ESR1
42doxorubicin45 50 1110.1PGR, ERBB2, CYP19A1, VIM, ESR1, HIF1A
43estradiol45 11 2410.0PRLR, PRL, ARSH, VIM, PGR, CYP19A1
44paraffin457.7PRLR, ESR1, ERBB2, PGR, FGF1, FGFR4
45genistein45 29 60 2 11 2412.7PGR, ERBB2, ESR1, FGF1, HIF1A, PRLR
46vegf457.6HIF1A, FGF1, FGFR4, ERBB2, ESR1, VIM
47progestin457.6PGR, PRL, PRLR, CYP19A1, ERBB2, ESR1
48progesterone45 60 29 11 2411.6VIM, PRLR, CYP19A1, PRL, PGR, ERBB2
49tamoxifen45 50 29 1110.1ESR1, ERBB2, PGR, FGF1, CYP19A1, HIF1A
50testosterone45 60 11 2410.1ERBB2, CYP19A1, PRLR, PRL, ARSH, ESR1

GO Terms for genes affiliated with Breast Fibroadenoma

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16Gene Ontology
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Biological processes related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1organ inductionGO:00175910.1FGFR4, FGF1
2positive regulation of nitric-oxide synthase activityGO:0510009.8ESR1, HIF1A
3JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.8PRLR, PRL
4lactationGO:0075959.8HIF1A, PRLR, PRL
5androgen metabolic processGO:0082099.7ESR1, CYP19A1
6positive regulation of epithelial cell proliferationGO:0506799.6ERBB2, FGF1, PRL
7phosphatidylinositol-mediated signalingGO:0480159.6ERBB2, FGF1, FGFR4
8steroid biosynthetic processGO:0066949.5CYP19A1, PRLR
9fibroblast growth factor receptor signaling pathwayGO:0085439.4FGFR4, FGF1, ERBB2
10cell surface receptor signaling pathwayGO:0071669.4ERBB2, PRLR, PRL
11signal transductionGO:0071658.5HIF1A, FGF1, PGR, ERBB2, ESR1

Molecular functions related to Breast Fibroadenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein C-terminus bindingGO:0080228.7ERBB2, SYNJ2BP, VIM

Products for genes affiliated with Breast Fibroadenoma

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  • Antibodies
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Sources for Breast Fibroadenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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