Breast Fibroadenoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Breast Fibroadenoma

Sources:
⁹Disease Ontology, ⁶⁴Wikipedia, ³²MalaCards
See all sources

Wikipedia:⁶⁴ Fibroadenomas of the breast are lumps composed of fibrous and glandular tissue. Because breast cancer... more...

MalaCards based summary: Breast Fibroadenoma, also known as fibroadenoma, is related to ductal carcinoma in situ and myoma. An important gene associated with Breast Fibroadenoma is HIF1A (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)), and among its related pathways are Signaling by FGFR1 mutants and FGF signaling pathway. The compounds fadrozole and idoxifene have been mentioned in the context of this disorder. Affiliated tissues include breast, breast and lung, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Disease Ontology:⁹ A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

Aliases & Classifications for Breast Fibroadenoma

Sources:
⁹Disease Ontology, ¹¹DISEASES, ⁴⁴Novoseek, ⁶¹UMLS, ⁵⁶SNOMED-CT, ³⁹NCIt
See all sources

Breast Fibroadenoma, Aliases & Descriptions:

Name: Breast Fibroadenoma ⁹ ¹¹ ⁴⁴

Fibroadenoma ⁹ ⁴⁴ ⁶¹

Juvenile Fibroadenoma of Breast ⁹ ⁶¹

Complex Fibroadenoma of Breast ⁹ ⁶¹

Fibroadenoma of Breast ⁹ ⁶¹

Juvenile Fibroadenoma ⁹

Cellular Fibroadenoma ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Cancer diseases, Rare diseases
Anatomical: Reproductive diseases

External Ids:

Disease Ontology⁹ DOID:1618

SNOMED-CT⁵⁶ 46212000, 269640007, 189102001 65877006, 189820007, 254845004, 254847007, more

NCIt³⁹ C3744

UMLS⁶¹ C0346158, C0178421, C1333137 C0206650, more

Related Diseases for Breast Fibroadenoma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 107)

id	Related Disease	Score	Top Affiliating Genes
1	ductal carcinoma in situ	30.2	PGR, ESR1, ERBB2
2	myoma	30.2	CYP19A1, PGR, ESR1
3	li-fraumeni syndrome	30.1	ERBB2, ESR1, PGR
4	adenoma	30.0	PRLR, FGFR4, FGF1, PRL
5	gynecomastia	29.4	ESR1, CYP19A1, PGR, PRL
6	breast cancer	29.1	CYP19A1, ERBB2, HIF1A, PGR, ESR1, FGF1
7	breast giant fibroadenoma	10.4
8	breast pericanalicular fibroadenoma	10.4
9	multiple fibroadenomas of the breast	10.3
10	phyllode tumor	10.3
11	pituitary carcinoma	10.3	PRL
12	myocardial infarction	10.3	HIF1A, FGF1
13	pseudoangiomatous stromal hyperplasia	10.2
14	endocrine gland cancer	10.2	ESR1, CYP19A1
15	cerebral meningioma	10.2	PGR, PRLR
16	uterine sarcoma	10.2	CYP19A1, ESR1
17	estrogen excess	10.2	PGR, CYP19A1
18	neurofibromatosis	10.2
19	pleomorphic adenoma	10.2	FGF1, ERBB2
20	sertoli cell tumor	10.2	CYP19A1, PGR
21	abrikosov's tumor	10.2	CYP19A1, ESR1
22	cribriform carcinoma	10.2	ESR1, PGR
23	osteoporosis, postmenopausal	10.2	CYP19A1, ESR1
24	progesterone resistance	10.2	PGR, ESR1
25	bilateral breast cancer	10.2	ESR1, PGR
26	leiomyomatosis	10.1	PGR, ESR1
27	adenosarcoma	10.1	PGR, ESR1
28	uterine fibroid	10.1	PGR, ESR1
29	beckwith-wiedemann syndrome	10.1
30	hodgkin's lymphoma	10.1
31	fibroma	10.1
32	transsexualism	10.1
33	medulloblastoma	10.1
34	gastric adenocarcinoma	10.1	FGF1, HIF1A, ERBB2
35	lymphangioleiomyomatosis	10.1	PGR, ESR1
36	angiomyolipoma	10.1	PGR, ESR1
37	squamous cell carcinoma of the head and neck	10.1	HIF1A, FGFR4, ERBB2
38	malignant mixed mullerian tumor	10.1	ERBB2, PGR
39	cervical adenocarcinoma	10.1	PGR, ESR1
40	lung adenocarcinoma	10.1	HIF1A, ERBB2, FGFR4
41	vascular disease	10.1	ESR1, HIF1A, FGF1
42	smooth muscle tumor	10.1	ESR1, PGR
43	hypogonadism, hypergonadotropic	10.1	CYP19A1, PRL
44	breast intracanalicular fibroadenoma	10.1
45	breast fibroadenosis	10.1
46	gigantomastia	10.1
47	ovarian disease	10.1	PRL, CYP19A1
48	anovulation	10.1	PRL, CYP19A1
49	hyperprolactinemia	10.1	PRL, PRLR
50	astrocytoma	10.1	HIF1A, FGF1, FGFR4

Graphical network of the top 20 diseases related to Breast Fibroadenoma:

Symptoms for Breast Fibroadenoma

Drugs & Therapeutics for Breast Fibroadenoma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Breast Fibroadenoma

Search NIH Clinical Center for Breast Fibroadenoma

Genetic Tests for Breast Fibroadenoma

Anatomical Context for Breast Fibroadenoma

Sources:
³²MalaCards, ¹⁵FMA
See all sources

MalaCards organs/tissues related to Breast Fibroadenoma:

³²

Breast, Lung

FMA organs/tissues related to Breast Fibroadenoma:

¹⁵

Breast

Animal Models for Breast Fibroadenoma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Breast Fibroadenoma:

³⁶ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	8.4	PRL, ESR1, HIF1A, CYP19A1
2	limbs/digits/tail phenotype	MP:0005371	8.3	HIF1A, PGR, ESR1, PRLR, ERBB2
3	normal phenotype	MP:0002873	8.2	CYP19A1, HIF1A, PGR, ERBB2, FGF1
4	embryogenesis phenotype	MP:0005380	8.2	ERBB2, PRLR, ESR1, PGR, HIF1A
5	muscle phenotype	MP:0005369	8.2	CYP19A1, HIF1A, PGR, ESR1, ERBB2
6	skeleton phenotype	MP:0005390	7.9	CYP19A1, HIF1A, PGR, ESR1, PRLR, ERBB2
7	growth/size/body phenotype	MP:0005378	7.8	CYP19A1, HIF1A, ESR1, PRLR, ERBB2, FGFR4
8	cardiovascular system phenotype	MP:0005385	7.8	CYP19A1, HIF1A, PGR, ESR1, ERBB2
9	cellular phenotype	MP:0005384	7.5	CYP19A1, HIF1A, PGR, ESR1, PRLR, ERBB2
10	tumorigenesis	MP:0002006	7.2	FGFR4, HIF1A, PGR, ESR1, PRL, PRLR
11	nervous system phenotype	MP:0003631	7.2	CYP19A1, HIF1A, ESR1, PRL, PRLR, ERBB2
12	endocrine/exocrine gland phenotype	MP:0005379	7.1	CYP19A1, HIF1A, PGR, ESR1, PRL, PRLR
13	integument phenotype	MP:0010771	7.1	CYP19A1, HIF1A, PGR, ESR1, PRL, PRLR
14	behavior/neurological phenotype	MP:0005386	7.1	CYP19A1, HIF1A, PGR, ESR1, PRL, PRLR
15	reproductive system phenotype	MP:0005389	7.0	CYP19A1, PGR, ESR1, PRL, PRLR, ERBB2
16	homeostasis/metabolism phenotype	MP:0005376	6.4	CYP19A1, HIF1A, PGR, ESR1, PRL, PRLR

Publications for Breast Fibroadenoma

Sources:
⁵¹PubMed
See all sources

Articles related to Breast Fibroadenoma:

(show top 50) (show all 54)

id	Title	Authors	Year
1	Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. (25038752)	Lim W.K.... Teh B.T.	2014
2	Ultrasound-guided cryoablation of breast fibroadenoma: a pilot trial. (25408274)	Golatta M.... Hahn M.	2014
3	High resolution compression elastography and color doppler sonography in characterization of breast fibroadenoma. (25227197)	Rjosk-Dendorfer D.... Clevert D.A.	2014
4	Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)	Limite G.... Forestieri P.	2013
5	Fine-needle aspiration of gray zone lesions of the breast: fibroadenoma versus ductal carcinoma. (22936545)	Jing X.... Michael C.W.	2013
6	First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)	Pacchiarotti A.... Frati P.	2013
7	Transaxillary approach with use of traction suture for excision of breast fibroadenoma: a new technique and its results. (22604577)	Khan P.S.... Hayat G.	2012
8	A clinical study on the resection of breast fibroadenoma using two types of incision. (22108740)	Liu X.F.... Lu C.	2011
9	Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. (22011321)	Marzese D.M.... Vargas-Roig L.M.	2011
10	Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue. (22249796)	Borges M.N.... Nazario A.C.	2011
11	Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: report of an unusual case with literature review. (21733035)	Zhang J.... Liu H.	2011
12	First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)	Pacchiarotti A.... Moscarini M.	2011
13	Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. (21192183)	Audisio T.... Ramallo R.	2011
14	Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. (21875284)	Bidgoli S.A.... Eftekhari T.	2011
15	Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. (22121516)	Abe M.... Iwase T.	2011
16	Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. (24376952)	PoA8om K.... Murawa P.	2010
17	Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (19897676)	Courtillot C.... Touraine P.	2010
18	A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. (19211906)	Moralidis E.... Karakatsanis C.	2009
19	Recurrence of giant juvenile breast fibroadenoma in a girl with Turner's syndrome. (19492586)	Calcaterra V.... Larizza D.	2009
20	Ectopic breast fibroadenoma of the vulva. (19622961)	Lucas E.W.... Moawad G.N.	2009
21	Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)	Zubor P.... Danko J.	2008
22	Invasive mucinous carcinoma arising within breast fibroadenoma. (18841829)	Charfi L.... Ben Romdhane K.	2008
23	Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. (18094894)	EstevALo R.A.... Baracat E.C.	2007
24	Breast fibroadenoma in female adolescents. (17206308)	Tiryaki T.... Kibar A.E.	2007
25	FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. (16961651)	Kollur S.M.... el Hag I.A.	2006
26	Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. (16297109)	Yuen S.... Furukawa H.	2005
27	Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. (16405127)	Yavisheva T.M.... Savluchinskaya L.A.	2005
28	p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. (15578730)	Di Vinci A.... Romani M.	2005
29	Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. (15450823)	Edwards M.J.... Oetting L.	2004
30	Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)	Lemmo G.... Garcea R.	2003
31	Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)	La Rosa S.... Capella C.	2001
32	Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. (10432878)	LA^pez-Ferrer P.... Viguer J.M.	1999
33	Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells. (10349403)	Lanjewar D.N.... Bhosale A.S.	1999
34	Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. (9885614)	Weinstein D.... Degani H.	1999
35	Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. (9278103)	Szylberg T.... Kulig A.	1997
36	Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)	Pasqualini J.R.... Ruiz A.	1997
37	Breast fibroadenoma with atypical features: a case report. (8629423)	Kordek R.... Kubiak R.	1996
38	Infarction of breast fibroadenoma in a postmenopausal woman. (8044310)	Ichihara S.... Aoyama H.	1994
39	Aspiration cytology of breast fibroadenoma with atypia. (1606889)	Chen K.T.	1992
40	Medulloblastoma metastasizing to a breast fibroadenoma: a case report. (2021436)	Brydon H.L.... Carey M.P.	1991
41	Possibilities of the conventional and interventional sonography in diagnosis of breast fibroadenoma. (1841055)	Nedeva A.... Ivanov V.	1991
42	Risk factors for breast fibroadenoma in young women. (2766721)	Sitruk-Ware R.... Mauvais-Jarvis P.	1989
43	Carcinoma in a breast fibroadenoma. (3473866)	Simpson R.H.... Yankah D.G.	1987
44	Estrogen receptor in dissociated and cultured human breast fibroadenoma epithelial cells. (3828977)	Balakrishnan A.... Nandi S.	1987
45	Morphometry of the breast fibroadenoma. (3562341)	Pesce C.... Colacino R.	1986
46	Management of breast fibroadenoma in women under 25 years of age. (3730963)	Kapoor V.K.... Sharma L.K.	1986
47	A radiodiagnostic study of breast fibroadenoma. (2949499)	Rocek V.... VojA!cek K.	1985
48	Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells. (6164351)	Ilyin K.V.... Morozov V.A.	1980
49	Breast fibroadenoma and cardiac anomaly associated with EMG (Beckwith-Wiedemann) syndrome. (430311)	Raine P.A.... Campbell P.E.	1979
50	The myoepithelium in human breast fibroadenoma. (4452932)	Ahmed A.	1974

Genes related to Breast Fibroadenoma

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Breast Fibroadenoma:

- Elite gene

id	Symbol	Description	Score	Implication
1	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	21.00	GeneCards inferred via : Disorders (show sections)
2	ARSH	arylsulfatase family, member H	18.95	GeneCards inferred via : Publications (show sections)
3	FGFR4	fibroblast growth factor receptor 4	16.95	GeneCards inferred via : Publications (show sections)
4	FGF1	fibroblast growth factor 1 (acidic)	14.95	GeneCards inferred via : Publications (show sections)
5	PRLR	prolactin receptor	12.95	GeneCards inferred via : Publications (show sections)
6	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	10.95	GeneCards inferred via : Publications (show sections)
7	ERBB2	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	8.95	GeneCards inferred via : Publications (show sections)
8	PGR	progesterone receptor	6.95	GeneCards inferred via : Disorders (show sections)
9	PRL	prolactin	4.95	GeneCards inferred via : Publications (show sections)
10	ESR1	estrogen receptor 1	2.95	GeneCards inferred via : Disorders (show sections)

Products for genes related to Breast Fibroadenoma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	10	-	10	10
2	Novus Biologicals	10	9	10	-

Variations for Breast Fibroadenoma

Expression for genes affiliated with Breast Fibroadenoma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Breast Fibroadenoma

Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

Sources:
⁴⁹PathCards, ⁵⁴Reactome, ³⁷NCBI BioSystems Database, ⁵²QIAGEN, ⁵⁰PharmGKB, ⁵Cell Signaling Technology, ³⁰KEGG, ⁵⁹Thomson Reuters
See all sources

Pathways related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 31)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Signaling by FGFR1 mutants⁵⁴ Show member pathways Signaling by FGFR1 fusion mutants⁵⁴ Signaling by FGFR mutants⁵⁴	9.8	FGF1, FGFR4
2	FGF signaling pathway³⁷	9.8	FGF1, FGFR4
3	Alzheimers Disease Pathway⁵²	9.6	ERBB2, FGFR4
4	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics⁵⁰ Show member pathways Estrogen biosynthesis⁵⁴	9.5	ESR1, CYP19A1
5	p70S6K Signaling⁵² Show member pathways Renin-Angiotensin Pathway⁵² mTOR Pathway⁵²	9.5	FGF1, HIF1A, FGFR4
6	Angiogenesis⁵	9.5	FGF1, FGFR4, HIF1A
7	Nuclear Receptor transcription pathway⁵⁴ Show member pathways Nuclear Receptors³⁷	9.3	PGR, ESR1
8	Pathways in cancer³⁰	9.3	FGF1, HIF1A, ERBB2
9	Growth hormone receptor signaling⁵⁴	9.2	PRLR, PRL
10	Signaling events mediated by PTP1B³⁷	9.2	PRLR, PRL
11	Transcription Ligand dependent activation of the ESR1 SP pathway⁵⁹ Show member pathways Development Ligand dependent activation of the ESR1 AP 1 pathway⁵⁹	9.2	ESR1, PRLR, HIF1A
12	Downstream Signaling Events Of B Cell Receptor (BCR)⁵⁴ Show member pathways Signaling by the B Cell Receptor (BCR)⁵⁴ Activation of RAS in B Cells⁵⁴	9.2	FGFR4, FGF1, ERBB2
13	Signaling by FGFR⁵⁴ Show member pathways Signaling by constitutively active EGFR⁵⁴ Signaling by EGFR⁵⁴ DAP12 interactions⁵⁴ DAP12 signaling⁵⁴ Signaling by ERBB2⁵⁴ Signaling by FGFR in disease⁵⁴ Signaling by PDGF⁵⁴ Downstream signaling of activated FGFR⁵⁴ Signaling by EGFR in Cancer⁵⁴ Signalling by NGF⁵⁴ Downstream signal transduction⁵⁴ Downregulation of ERBB2-ERBB3 signaling⁵⁴ NGF signalling via TRKA from the plasma membrane⁵⁴	9.2	ERBB2, FGF1, FGFR4
14	Ca-dependent events⁵⁴ Show member pathways Neurophysiological process PGE2 induced pain processing⁵⁹ PLC-gamma1 signalling⁵⁴ Development Beta adrenergic receptors signaling via cAMP⁵⁹ Cam-PDE 1 activation⁵⁴ Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling⁵⁹ Opioid Signalling⁵⁴ CaM pathway⁵⁴ DAG and IP3 signaling⁵⁴ PLC beta mediated events⁵⁴ Signal transduction Calcium signaling⁵⁹ G-protein mediated events⁵⁴ PLCG1 events in ERBB2 signaling⁵⁴ Beta 2 adrenergic dependent CFTR expression⁵⁹ Phospholipase C-mediated cascade⁵⁴ CREB phosphorylation through the activation of Adenylate Cyclase⁵⁴ PKA-mediated phosphorylation of CREB⁵⁴ PKA activation in glucagon signalling⁵⁴ Development Role of Activin A in cell differentiation and proliferation⁵⁹ PKA activation⁵⁴ EGFR interacts with phospholipase C-gamma⁵⁴ Calmodulin induced events⁵⁴	9.2	FGF1, ERBB2, FGFR4
15	Tyrosine Kinases / Adaptors⁵	9.2	FGF1, FGFR4, ERBB2
16	Integrated Pancreatic Cancer Pathway³⁷	9.1	ERBB2, ESR1, FGF1
17	Ovarian Infertility Genes³⁷	9.0	CYP19A1, PRLR, PGR
18	Proteoglycans in cancer³⁰	8.8	ERBB2, HIF1A, ESR1, FGF1
19	ErbB4 signaling events³⁷	8.7	PRLR, ERBB2, PRL
20	GPCR Pathway⁵² Show member pathways Breast Cancer Regulation by Stathmin1⁵² Pancreatic Adenocarcinoma⁵² P2Y Receptor Signaling⁵² Ras Pathway⁵² Paxillin Interactions⁵² NFAT in Immune Response⁵² Estrogen Pathway⁵²	8.7	FGFR4, FGF1, ESR1, ERBB2
21	Nanog in Mammalian ESC Pluripotency⁵² Show member pathways GSK3 Signaling⁵² eNOS Signaling⁵² 14-3-3 Induced Intracellular Signaling⁵²	8.7	FGFR4, FGF1, ESR1, ERBB2
22	PI3K-Akt signaling pathway³⁰	8.5	PRLR, PRL, FGF1, FGFR4
23	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	8.4	HIF1A, FGFR4, ESR1, ERBB2, FGF1
24	PEDF Induced Signaling⁵² Show member pathways all-trans-Retinoic Acid Signaling in Brain⁵² Cytokine-cytokine receptor interaction³⁰ NFAT Signaling and Lymphocyte Interactions⁵² STAT3 Pathway⁵² RAR-Gamma-RXR-Alpha Degradation⁵² PGC1Alpha Pathway⁵² Glucocorticoid Receptor Signaling⁵² IL-6 Pathway⁵² Endothelin-1 Signaling Pathway⁵² MIF Regulation of Innate Immune Cells⁵² MIF Mediated Glucocorticoid Regulation⁵²	8.4	PRLR, ERBB2, FGFR4, PRL
25	Prolactin signaling pathway³⁰ Show member pathways Prolactin Signaling Pathway³⁷ Development Prolactin receptor signaling⁵⁹ Leptin signaling pathway³⁷	8.2	ERBB2, PRL, ESR1, PRLR
26	Disease⁵⁴	8.1	FGF1, ERBB2, PRL, HIF1A, FGFR4
27	Nuclear signaling by ERBB4⁵⁴ Show member pathways Prolactin receptor signaling⁵⁴	8.1	PGR, PRLR, PRL, ESR1
28	ErbB4 Pathway⁵² Show member pathways UVC-Induced MAPK Signaling⁵² FGF Pathway⁵² LPS Stimulated MAPK Signaling⁵² Growth Hormone Signaling⁵² HMGB1 Pathway⁵² PACAP Signaling⁵² IL-4 Pathway⁵² Prolactin Signaling⁵² Thrombopoietin Pathway⁵² ErbB2-ErbB3 Heterodimers⁵² IL-2 Pathway⁵² PI3K Signaling in B-Lymphocyte⁵² TREM1 Pathway⁵² ErbB Family Pathway⁵²	8.0	ERBB2, FGF1, FGFR4, PRLR, PRL
29	TGF-Beta Pathway⁵² Show member pathways SOCS Pathway⁵² JAK-STAT Pathway⁵² Regulation of eIF4 and p70S6K⁵² JNK Pathway⁵² MAPK Family Pathway⁵²	8.0	ERBB2, FGFR4, PRL, PRLR, FGF1
30	PI-3K cascade⁵⁴ Show member pathways Downregulation of ERBB4 signaling⁵⁴ AKT phosphorylates targets in the nucleus⁵⁴ Signaling by SCF-KIT⁵⁴ PI3K events in ERBB2 signaling⁵⁴ Fc epsilon receptor (FCERI) signaling⁵⁴ PI3K events in ERBB4 signaling⁵⁴ Signaling by ERBB4⁵⁴ GAB1 signalosome⁵⁴ Negative regulation of the PI3K/AKT network⁵⁴ Role of LAT2/NTAL/LAB on calcium mobilization⁵⁴ PIP3 activates AKT signaling⁵⁴ Regulation of KIT signaling⁵⁴ AKT phosphorylates targets in the cytosol⁵⁴ AKT-mediated inactivation of FOXO1A⁵⁴ PI3K/AKT Signaling in Cancer⁵⁴ Constitutive PI3K/AKT Signaling in Cancer⁵⁴ PI3K/AKT activation⁵⁴	6.9	FGFR4, PGR, ESR1, PRL, PRLR, ERBB2
31	Signaling by GPCR⁵⁴ Show member pathways GPCR downstream signaling⁵⁴ Signal Transduction⁵⁴	6.6	PRLR, FGFR4, FGF1, ERBB2, HIF1A, PRL

Compounds for genes affiliated with Breast Fibroadenoma

Sources:
⁴⁴Novoseek, ²⁵HMDB, ²⁹IUPHAR, ¹²DrugBank, ⁵⁰PharmGKB, ⁶⁰Tocris Bioscience, ³BitterDB
See all sources

Compounds related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show top 50) (show all 128)

id	Compound	Score	Top Affiliating Genes
1	fadrozole⁴⁴	9.2	ESR1, ERBB2, CYP19A1
2	idoxifene⁴⁴	9.2	ESR1, PGR, CYP19A1
3	nandrolone⁴⁴ ²⁵	9.9	PGR, ESR1, CYP19A1
4	tibolone⁴⁴	8.9	CYP19A1, PGR, ESR1, ARSH
5	steroidal⁴⁴	8.8	ARSH, PGR, CYP19A1, ESR1
6	goserelin⁴⁴ ²⁹ ¹²	10.8	PGR, ESR1, CYP19A1
7	megestrol acetate⁴⁴	8.8	ERBB2, PGR, CYP19A1, ESR1
8	17beta-hydroxysteroid⁴⁴	8.8	CYP19A1, ARSH, PGR, ESR1
9	exemestane⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.7	CYP19A1, ESR1, PGR, ERBB2
10	anastrozole⁴⁴ ⁵⁰ ¹²	10.7	CYP19A1, PGR, ERBB2, ESR1
11	lapatinib⁴⁴ ⁵⁰ ¹²	10.7	ERBB2, CYP19A1, ESR1, PGR
12	nomegestrol acetate⁴⁴	8.7	PGR, ESR1, ARSH
13	fulvestrant⁴⁴ ⁵⁰ ²⁹ ¹²	11.7	ERBB2, PGR, CYP19A1, ESR1
14	bisphenol a⁴⁴	8.7	ARSH, PGR, HIF1A, CYP19A1, ESR1
15	letrozole⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.7	CYP19A1, PGR, ESR1, ERBB2
16	taxane⁴⁴	8.7	CYP19A1, PGR, ESR1, ERBB2
17	progestins⁴⁴	8.6	ARSH, PRLR, CYP19A1, PGR, ESR1
18	raloxifene⁴⁴ ⁵⁰ ²⁹ ¹²	11.5	ERBB2, ESR1, CYP19A1, PGR
19	geldanamycin⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.5	FGF1, ERBB2, ESR1, HIF1A, PGR
20	estradiol benzoate⁴⁴	8.5	CYP19A1, PGR, PRL, ESR1
21	trastuzumab⁴⁴ ⁵⁰ ¹²	10.5	HIF1A, CYP19A1, PGR, ESR1, ERBB2
22	leuprolide acetate⁴⁴	8.5	ESR1, PRL, CYP19A1, PGR
23	4-hydroxytamoxifen⁴⁴	8.4	PGR, CYP19A1, ESR1, ERBB2, ARSH
24	clomiphene citrate⁴⁴	8.4	PGR, CYP19A1, ESR1, PRL
25	levonorgestrel⁴⁴ ⁶⁰ ²⁹ ¹²	11.4	CYP19A1, PGR, PRL, ESR1
26	docetaxel⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.3	ERBB2, ESR1, PGR, HIF1A, CYP19A1
27	flutamide⁴⁴ ⁶⁰ ¹²	10.3	PGR, ESR1, PRL, CYP19A1
28	cyclophosphamide⁴⁴ ⁵⁰ ¹²	10.3	ERBB2, ESR1, PGR, HIF1A, CYP19A1
29	methotrexate⁵⁰ ⁴⁴ ¹²	10.2	ERBB2, CYP19A1, ESR1, HIF1A, PGR
30	danazol⁴⁴ ²⁵ ¹²	10.2	PRL, CYP19A1, PGR, ARSH, ESR1
31	5fluorouracil⁴⁴	8.2	ESR1, ERBB2, PGR, CYP19A1, HIF1A
32	estrone sulfate⁴⁴ ²⁵	9.2	ARSH, PRL, ESR1, PGR, CYP19A1
33	estrone⁴⁴ ²⁹ ²⁵ ¹²	11.1	PGR, PRL, CYP19A1, ARSH, ESR1
34	paclitaxel⁴⁴ ⁵⁰ ¹²	10.1	HIF1A, PGR, CYP19A1, ESR1, ERBB2
35	toremifene⁴⁴ ¹²	9.0	ERBB2, ESR1, PGR, CYP19A1, PRL
36	dihydrotestosterone⁴⁴ ²⁹ ²⁵ ¹²	10.9	ESR1, HIF1A, ARSH, PRL, PGR, CYP19A1
37	paraffin⁴⁴	7.8	PRLR, FGFR4, FGF1, ERBB2, ESR1, PGR
38	vegf⁴⁴	7.8	FGFR4, HIF1A, FGF1, ERBB2, ESR1, PGR
39	genistein⁴⁴ ²⁹ ⁶⁰ ³ ²⁵ ¹²	12.7	PGR, PRLR, HIF1A, CYP19A1, ERBB2, FGF1
40	cycloheximide⁴⁴	7.7	PRLR, FGF1, ERBB2, CYP19A1, HIF1A, ESR1
41	arginine⁴⁴	7.6	FGF1, ARSH, CYP19A1, HIF1A, PRL, ERBB2
42	estradiol⁴⁴ ²⁵ ¹²	9.6	ARSH, ESR1, CYP19A1, PGR, PRLR, PRL
43	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	10.3	PRL, PGR, CYP19A1, HIF1A, PRLR, ERBB2
44	progestin⁴⁴	7.3	ESR1, CYP19A1, PGR, ARSH, ERBB2, PRLR
45	gnrh⁴⁴	7.2	ERBB2, PRLR, ARSH, CYP19A1, PGR, ESR1
46	progesterone⁴⁴ ²⁹ ⁶⁰ ²⁵ ¹²	11.2	ARSH, ERBB2, PRL, PRLR, CYP19A1, ESR1
47	steroid⁴⁴	7.2	CYP19A1, PGR, ESR1, PRL, ARSH, ERBB2
48	tamoxifen⁴⁴ ⁵⁰ ²⁹ ¹²	9.6	PRL, ERBB2, ARSH, FGF1, ESR1, HIF1A
49	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	9.6	CYP19A1, ARSH, HIF1A, PGR, ESR1, PRL
50	estrogen⁴⁴	6.6	ESR1, PRL, PGR, PRLR, ERBB2, ARSH

GO Terms for genes affiliated with Breast Fibroadenoma

Sources:
¹⁷Gene Ontology
See all sources

Biological processes related to Breast Fibroadenoma according to GeneCards/GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	organ induction	GO:001759	10.0	FGFR4, FGF1
2	positive regulation of nitric-oxide synthase activity	GO:051000	9.9	ESR1, HIF1A
3	androgen metabolic process	GO:008209	9.7	CYP19A1, ESR1
4	steroid biosynthetic process	GO:006694	9.6	PRLR, CYP19A1
5	positive regulation of epithelial cell proliferation	GO:050679	9.6	FGF1, ERBB2
6	phosphatidylinositol-mediated signaling	GO:048015	9.5	ERBB2, FGF1, FGFR4
7	fibroblast growth factor receptor signaling pathway	GO:008543	9.4	FGFR4, FGF1, ERBB2
8	Fc-epsilon receptor signaling pathway	GO:038095	9.3	FGFR4, FGF1, ERBB2
9	epidermal growth factor receptor signaling pathway	GO:007173	9.3	ERBB2, FGF1, FGFR4
10	lactation	GO:007595	9.2	PRLR, PRL, HIF1A
11	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	9.1	PRLR, PRL
12	neurotrophin TRK receptor signaling pathway	GO:048011	8.9	ERBB2, FGF1, FGFR4
13	cell surface receptor signaling pathway	GO:007166	8.9	ERBB2, PRLR, PRL
14	signal transduction	GO:007165	8.4	FGF1, ERBB2, ESR1, PGR, HIF1A

Molecular functions related to Breast Fibroadenoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	steroid binding	GO:005496	9.3	ESR1, PGR
2	steroid hormone receptor activity	GO:003707	9.0	PGR, ESR1
3	enzyme binding	GO:019899	8.9	ESR1, PGR, HIF1A
4	protein binding	GO:005515	6.9	PGR, ESR1, PRL, PRLR, ERBB2, FGF1