MCID: BRS053
MIFTS: 48

Breast Fibroadenoma malady

Genetic diseases, Reproductive diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Breast Fibroadenoma

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Breast Fibroadenoma, Aliases & Descriptions:

Name: Breast Fibroadenoma 9 11 43
Fibroadenoma 9 43 60
Juvenile Fibroadenoma of Breast 9 60
Fibroadenoma of Breast 9 60
 
Complex Fibroadenoma of Breast 9
Juvenile Fibroadenoma 9
Cellular Fibroadenoma 9
Complex Fibroadenoma 60


Classifications:



Summaries for Breast Fibroadenoma

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Wikipedia:63 Fibroadenomas of the breast are noncancerous tumors composed of fibrous and glandular tissue. Because... more...

MalaCards based summary: Breast Fibroadenoma, also known as fibroadenoma, is related to ductal carcinoma in situ and myoma. An important gene associated with Breast Fibroadenoma is HIF1A (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)), and among its related pathways are Signaling by FGFR1 mutants and FGF signaling pathway. The compounds fadrozole and idoxifene have been mentioned in the context of this disorder. Affiliated tissues include breast, breast and lung, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Disease Ontology:9 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

Related Diseases for Breast Fibroadenoma

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Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1ductal carcinoma in situ30.2PGR, ESR1, ERBB2
2myoma30.2CYP19A1, PGR, ESR1
3breast cancer30.1ERBB2, ESR1, PGR
4adenoma30.0PRL, PRLR, FGF1, FGFR4
5li-fraumeni syndrome29.5CYP19A1, PGR, ESR1, PRLR, ERBB2
6gynecomastia29.3CYP19A1, PGR, ESR1, PRL
7multiple fibroadenomas of the breast10.4
8breast giant fibroadenoma10.3
9phyllode tumor10.3
10pituitary carcinoma10.3PRL
11myocardial infarction10.3HIF1A, FGF1
12endocrine gland cancer10.2CYP19A1, ESR1
13cerebral meningioma10.2PGR, PRLR
14uterine sarcoma10.2CYP19A1, ESR1
15breast intracanalicular fibroadenoma10.2
16breast fibroadenosis10.2
17breast pericanalicular fibroadenoma10.2
18chickenpox10.2
19fibromatosis10.2
20estrogen excess10.2CYP19A1, PGR
21pleomorphic adenoma10.2FGF1, ERBB2
22sertoli cell tumor10.2CYP19A1, PGR
23abrikosov's tumor10.2ESR1, CYP19A1
24osteoporosis10.2ESR1, CYP19A1
25cribriform carcinoma10.2PGR, ESR1
26progesterone resistance10.2ESR1, PGR
27bilateral breast cancer10.1ESR1, PGR
28leiomyomatosis10.1PGR, ESR1
29androgen insensitivity10.1
30neurofibromatosis10.1
31granular cell tumor10.1
32scoliosis10.1
33complete androgen insensitivity syndrome10.1
34gigantomastia10.1
35pseudoangiomatous stromal hyperplasia10.1
36adenosarcoma10.1PGR, ESR1
37medulloblastoma10.1
38beckwith-wiedemann syndrome10.1
39transsexualism10.1
40uterine fibroid10.1PGR, ESR1
41gastric adenocarcinoma10.1FGF1, ERBB2, HIF1A
42lymphangioleiomyomatosis10.1ESR1, PGR
43angiomyolipoma10.1PGR, ESR1
44squamous cell carcinoma, head and neck10.1FGFR4, ERBB2, HIF1A
45malignant mixed mullerian tumor10.1ERBB2, PGR
46cervical adenocarcinoma10.1ESR1, PGR
47lung cancer susceptibility 310.1HIF1A, ERBB2, FGFR4
48smooth muscle tumor10.1PGR, ESR1
49vascular disease10.1HIF1A, ESR1, FGF1
50premature ovarian failure10.1PRL, CYP19A1

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to breast fibroadenoma

Symptoms for Breast Fibroadenoma

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Drugs & Therapeutics for Breast Fibroadenoma

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Drug clinical trials:

Search ClinicalTrials for Breast Fibroadenoma

Search NIH Clinical Center for Breast Fibroadenoma

Genetic Tests for Breast Fibroadenoma

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Anatomical Context for Breast Fibroadenoma

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MalaCards organs/tissues related to Breast Fibroadenoma:

31
Breast, Lung

FMA organs/tissues related to Breast Fibroadenoma:

14
Breast

Animal Models for Breast Fibroadenoma or affiliated genes

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Publications for Breast Fibroadenoma

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Articles related to Breast Fibroadenoma:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma-a multicenter experience. (25635224)
2015
2
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. (25038752)
2014
3
Ultrasound-guided cryoablation of breast fibroadenoma: a pilot trial. (25408274)
2014
4
High resolution compression elastography and color doppler sonography in characterization of breast fibroadenoma. (25227197)
2014
5
Lobular intraepithelial neoplasia arising within breast fibroadenoma. (23849288)
2013
6
Fine-needle aspiration of gray zone lesions of the breast: fibroadenoma versus ductal carcinoma. (22936545)
2013
7
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
8
Transaxillary approach with use of traction suture for excision of breast fibroadenoma: a new technique and its results. (22604577)
2012
9
A clinical study on the resection of breast fibroadenoma using two types of incision. (22108740)
2011
10
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. (22011321)
2011
11
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue. (22249796)
2011
12
First case of transformation for breast fibroadenoma toA high-grade malignant cystosarcoma in an inA vitro fertilization patient. (21917252)
2011
13
Fibroadenoma of the vulva--simultaneous with breast fibroadenomas and uterine myoma. (21192183)
2011
14
Role of exogenous and endogenous sources of estrogen on the incidence of breast fibroadenoma: case-control study in Iran. (21875284)
2011
15
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. (22121516)
2011
16
Vacuum-assisted core-needle biopsy as a diagnostic and therapeutic method in lesions radiologically suspicious of breast fibroadenoma. (24376952)
2010
17
Characterization of two constitutively active prolactin receptor variants in a cohort of 95 women with multiple breast fibroadenomas. (19897676)
2010
18
A breast fibroadenoma mimicking an extranodal deposit of Hodgkin's lymphoma in 67Ga imaging. (19211906)
2009
19
Recurrence of giant juvenile breast fibroadenoma in a girl with Turner's syndrome. (19492586)
2009
20
Ectopic breast fibroadenoma of the vulva. (19622961)
2009
21
Herb-related aneuploidy in breast fibroadenoma. (21686556)
2009
22
Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (18090908)
2008
23
Invasive mucinous carcinoma arising within breast fibroadenoma. (18841829)
2008
24
Effect of oral contraceptive with and without associated estriol on ultrasound measurements of breast fibroadenoma: randomized clinical trial. (18094894)
2007
25
Breast fibroadenoma in female adolescents. (17206308)
2007
26
FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. (16961651)
2006
27
Magnetic resonance imaging findings in an axillary accessory breast fibroadenoma. (16297109)
2005
28
Characteristic features of function of morphofunctional zones in normal epithelium, breast fibroadenoma, and breast cancer. (16405127)
2005
29
p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma. (15578730)
2005
30
Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. (15450823)
2004
31
Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. (15200048)
2003
32
Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas. (11271786)
2001
33
Fine needle aspiration cytology of breast fibroadenoma. A cytohistologic correlation study of 405 cases. (10432878)
1999
34
Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells. (10349403)
1999
35
Breast fibroadenoma: mapping of pathophysiologic features with three-time-point, contrast-enhanced MR imaging--pilot study. (9885614)
1999
36
Diagnostic value of fine needle aspiration biopsy for breast fibroadenoma diagnosis. (9278103)
1997
37
Concentrations of estrone, estradiol and their sulfates, and evaluation of sulfatase and aromatase activities in patients with breast fibroadenoma. (9096642)
1997
38
Breast fibroadenoma with atypical features: a case report. (8629423)
1996
39
Aspiration cytology of breast fibroadenoma with atypia. (1606889)
1992
40
Medulloblastoma metastasizing to a breast fibroadenoma: a case report. (2021436)
1991
41
Possibilities of the conventional and interventional sonography in diagnosis of breast fibroadenoma. (1841055)
1991
42
Risk factors for breast fibroadenoma in young women. (2766721)
1989
43
Carcinoma in a breast fibroadenoma. (3473866)
1987
44
Estrogen receptor in dissociated and cultured human breast fibroadenoma epithelial cells. (3828977)
1987
45
Morphometry of the breast fibroadenoma. (3562341)
1986
46
Management of breast fibroadenoma in women under 25 years of age. (3730963)
1986
47
A radiodiagnostic study of breast fibroadenoma. (2949499)
1985
48
Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells. (6164351)
1980
49
Breast fibroadenoma and cardiac anomaly associated with EMG (Beckwith-Wiedemann) syndrome. (430311)
1979
50
The myoepithelium in human breast fibroadenoma. (4452932)
1974

Variations for Breast Fibroadenoma

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Expression for genes affiliated with Breast Fibroadenoma

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Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for genes affiliated with Breast Fibroadenoma

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Pathways related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8FGFR4, FGF1
29.8FGFR4, FGF1
39.6FGFR4, ERBB2
4
Show member pathways
9.5ESR1, CYP19A1
5
Show member pathways
9.5FGFR4, FGF1, HIF1A
69.5FGFR4, FGF1, HIF1A
7
Show member pathways
Nuclear Receptors36
9.3ESR1, PGR
89.3HIF1A, ERBB2, FGF1
99.2PRL, PRLR
109.2PRL, PRLR
11
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway58
9.2HIF1A, ESR1, PRLR
12
Show member pathways
9.2FGFR4, FGF1, ERBB2
13
Show member pathways
9.2FGFR4, FGF1, ERBB2
14
Show member pathways
9.2ERBB2, FGF1, FGFR4
159.2FGFR4, FGF1, ERBB2
169.1ESR1, ERBB2, FGF1
179.0CYP19A1, PGR, PRLR
188.8FGF1, ERBB2, ESR1, HIF1A
198.7PRL, PRLR, ERBB2
20
Show member pathways
8.7FGFR4, FGF1, ERBB2, ESR1
21
Show member pathways
8.7ESR1, ERBB2, FGF1, FGFR4
228.5PRL, PRLR, FGF1, FGFR4
23
Show member pathways
8.4HIF1A, ESR1, ERBB2, FGF1, FGFR4
24
Show member pathways
8.4FGFR4, ERBB2, PRLR, PRL
25
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
8.2ERBB2, PRLR, PRL, ESR1
268.1HIF1A, PRL, ERBB2, FGF1, FGFR4
27
Show member pathways
8.1PGR, ESR1, PRL, PRLR
28
Show member pathways
8.0PRL, PRLR, ERBB2, FGF1, FGFR4
29
Show member pathways
8.0PRL, PRLR, ERBB2, FGF1, FGFR4
30
Show member pathways
6.9FGFR4, FGF1, ERBB2, PRLR, PRL, ESR1
31
Show member pathways
6.6HIF1A, PGR, ESR1, PRL, PRLR, ERBB2

Compounds for genes affiliated with Breast Fibroadenoma

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Compounds related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 128)
idCompoundScoreTop Affiliating Genes
1fadrozole439.2CYP19A1, ESR1, ERBB2
2idoxifene439.2ESR1, PGR, CYP19A1
3nandrolone43 249.9ESR1, PGR, CYP19A1
4tibolone438.9CYP19A1, PGR, ESR1, ARSH
5steroidal438.8CYP19A1, PGR, ESR1, ARSH
6goserelin43 28 1210.8ESR1, PGR, CYP19A1
7megestrol acetate438.8ERBB2, ESR1, PGR, CYP19A1
817beta-hydroxysteroid438.8ARSH, ESR1, PGR, CYP19A1
9anastrozole43 49 1210.7CYP19A1, PGR, ESR1, ERBB2
10exemestane43 49 59 1211.7CYP19A1, PGR, ESR1, ERBB2
11lapatinib43 49 1210.7CYP19A1, PGR, ESR1, ERBB2
12nomegestrol acetate438.7PGR, ESR1, ARSH
13fulvestrant43 49 28 1211.7ERBB2, ESR1, PGR, CYP19A1
14bisphenol a438.7CYP19A1, HIF1A, PGR, ESR1, ARSH
15taxane438.7CYP19A1, PGR, ESR1, ERBB2
16letrozole43 49 59 1211.7CYP19A1, PGR, ESR1, ERBB2
17progestins438.6CYP19A1, PGR, ESR1, PRLR, ARSH
18raloxifene43 49 28 1211.5CYP19A1, PGR, ESR1, ERBB2
19geldanamycin43 49 59 1211.5FGF1, ERBB2, ESR1, PGR, HIF1A
20estradiol benzoate438.5CYP19A1, PGR, ESR1, PRL
21trastuzumab43 49 1210.5ERBB2, ESR1, PGR, HIF1A, CYP19A1
22leuprolide acetate438.5CYP19A1, PGR, ESR1, PRL
234-hydroxytamoxifen438.4CYP19A1, PGR, ESR1, ERBB2, ARSH
24clomiphene citrate438.4CYP19A1, PGR, ESR1, PRL
25levonorgestrel43 59 28 1211.4CYP19A1, PGR, ESR1, PRL
26docetaxel43 49 59 1211.3CYP19A1, HIF1A, PGR, ESR1, ERBB2
27flutamide43 59 1210.3PRL, ESR1, PGR, CYP19A1
28cyclophosphamide43 49 1210.3ERBB2, ESR1, PGR, HIF1A, CYP19A1
29methotrexate49 43 1210.2ERBB2, ESR1, PGR, HIF1A, CYP19A1
30danazol43 24 1210.2CYP19A1, PGR, ESR1, PRL, ARSH
315fluorouracil438.2CYP19A1, HIF1A, PGR, ESR1, ERBB2
32estrone sulfate43 249.2CYP19A1, PGR, ESR1, PRL, ARSH
33estrone43 28 24 1211.1CYP19A1, PGR, ESR1, PRL, ARSH
34paclitaxel43 49 1210.1CYP19A1, HIF1A, PGR, ESR1, ERBB2
35toremifene43 129.0CYP19A1, PGR, ESR1, PRL, ERBB2
36dihydrotestosterone43 28 24 1210.9CYP19A1, HIF1A, PGR, ESR1, PRL, ARSH
37paraffin437.8HIF1A, PGR, ESR1, PRLR, ERBB2, FGF1
38vegf437.8FGFR4, FGF1, ERBB2, ESR1, PGR, HIF1A
39genistein43 28 59 2 24 1212.7CYP19A1, HIF1A, PGR, ESR1, PRLR, ERBB2
40cycloheximide437.7CYP19A1, HIF1A, PGR, ESR1, PRLR, ERBB2
41arginine437.6CYP19A1, HIF1A, PRL, ERBB2, ARSH, FGF1
42estradiol43 24 129.6CYP19A1, PGR, ESR1, PRL, PRLR, ARSH
43dexamethasone43 49 28 1210.3CYP19A1, HIF1A, PGR, PRL, PRLR, ERBB2
44progestin437.2CYP19A1, PGR, ESR1, PRL, PRLR, ERBB2
45gnrh437.2CYP19A1, PGR, ESR1, PRL, PRLR, ERBB2
46progesterone43 28 59 24 1211.2CYP19A1, PGR, ESR1, PRL, PRLR, ERBB2
47steroid437.2CYP19A1, PGR, ESR1, PRL, PRLR, ERBB2
48tamoxifen43 49 28 129.6FGF1, CYP19A1, HIF1A, ARSH, ERBB2, PRLR
49testosterone43 59 24 129.6CYP19A1, HIF1A, PGR, ESR1, PRL, PRLR
50estrogen436.6CYP19A1, HIF1A, PGR, ESR1, PRL, PRLR

GO Terms for genes affiliated with Breast Fibroadenoma

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Biological processes related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1organ inductionGO:000175910.0FGFR4, FGF1
2positive regulation of nitric-oxide synthase activityGO:00510009.9ESR1, HIF1A
3androgen metabolic processGO:00082099.7CYP19A1, ESR1
4steroid biosynthetic processGO:00066949.6PRLR, CYP19A1
5positive regulation of epithelial cell proliferationGO:00506799.6FGF1, ERBB2
6phosphatidylinositol-mediated signalingGO:00480159.5ERBB2, FGF1, FGFR4
7fibroblast growth factor receptor signaling pathwayGO:00085439.4FGFR4, FGF1, ERBB2
8Fc-epsilon receptor signaling pathwayGO:00380959.3FGFR4, FGF1, ERBB2
9epidermal growth factor receptor signaling pathwayGO:00071739.3ERBB2, FGF1, FGFR4
10lactationGO:00075959.2PRLR, PRL, HIF1A
11JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.1PRLR, PRL
12neurotrophin TRK receptor signaling pathwayGO:00480118.9ERBB2, FGF1, FGFR4
13cell surface receptor signaling pathwayGO:00071668.9ERBB2, PRLR, PRL
14signal transductionGO:00071658.4FGF1, ERBB2, ESR1, PGR, HIF1A

Molecular functions related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00054969.3ESR1, PGR
2steroid hormone receptor activityGO:00037079.0PGR, ESR1
3enzyme bindingGO:00198998.9ESR1, PGR, HIF1A
4protein bindingGO:00055156.9PGR, ESR1, PRL, PRLR, ERBB2, FGF1

Products for genes affiliated with Breast Fibroadenoma

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Sources for Breast Fibroadenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet