MCID: BRS011
MIFTS: 20

Breast Fibrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Fibrosarcoma

MalaCards integrated aliases for Breast Fibrosarcoma:

Name: Breast Fibrosarcoma 12 14 69
Fibrosarcoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6001
NCIt 47 C5185
UMLS 69 C1332630

Summaries for Breast Fibrosarcoma

MalaCards based summary : Breast Fibrosarcoma, also known as fibrosarcoma of the breast, is related to fibrosarcoma and overuse syndrome. An important gene associated with Breast Fibrosarcoma is STIM1 (Stromal Interaction Molecule 1), and among its related pathways/superpathways is Ca, cAMP and Lipid Signaling. The drugs Cyclophosphamide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include breast and liver.

Related Diseases for Breast Fibrosarcoma

Diseases related to Breast Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 fibrosarcoma 9.8
2 overuse syndrome 9.6 CALB1 PVALB
3 idiopathic generalized epilepsy 9.6 CALB1 PVALB
4 adrenal gland pheochromocytoma 9.5 CALB1 PVALB
5 long qt syndrome 5 9.5 CALB1 PVALB
6 testicular lymphoma 9.4 CALB1 PVALB
7 mucopolysaccharidosis iii 9.2 CALB1 PVALB
8 adult central nervous system mature teratoma 9.0 CALB1 PVALB STIM1

Graphical network of the top 20 diseases related to Breast Fibrosarcoma:



Diseases related to Breast Fibrosarcoma

Symptoms & Phenotypes for Breast Fibrosarcoma

Drugs & Therapeutics for Breast Fibrosarcoma

Drugs for Breast Fibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved Phase 2, Phase 3 51-75-2 4033
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6 Alkylating Agents Phase 2, Phase 3
7 Anti-Bacterial Agents Phase 2, Phase 3
8 Antibiotics, Antitubercular Phase 2, Phase 3
9 Isophosphamide mustard Phase 2, Phase 3
10 Topoisomerase Inhibitors Phase 2, Phase 3
11
nivolumab Approved Phase 2 946414-94-4
12 Imatinib Mesylate Phase 2 123596
13 Protein Kinase Inhibitors Phase 2
14 Antibodies Phase 2
15 Antibodies, Monoclonal Phase 2
16 Immunoglobulins Phase 2
17 tyrosine Nutraceutical Phase 2,Phase 1
18
Belinostat Approved, Investigational Phase 1 866323-14-0
19
Fluorouracil Approved Phase 1 51-21-8 3385
20 Histone Deacetylase Inhibitors Phase 1
21 Androgens Phase 1
22 Antimetabolites Phase 1
23 Antimetabolites, Antineoplastic Phase 1
24 Immunosuppressive Agents Phase 1
25 Liver Extracts Early Phase 1
26 Cola Nutraceutical Early Phase 1

Interventional clinical trials:

(show all 11)

id Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
2 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
3 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
4 Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes Completed NCT00171912 Phase 2 imatinib mesylate
5 Phase 1/2 Study of LOXO-195 in Patients With Previously Treated NTRK Fusions or Non-fusion NTRK Cancers Recruiting NCT03215511 Phase 1, Phase 2 LOXO-195
6 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
7 Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma Suspended NCT02601209 Phase 1, Phase 2 Pazopanib Hydrochloride;Sapanisertib
8 Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00413075 Phase 1 oral belinostat
9 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)
10 Study of RXDX-101 in Children With Recurrent or Refractory Solid Tumors and Primary CNS Tumors, With or Without TRK, ROS1, or ALK Fusions Recruiting NCT02650401 Phase 1 Entrectinib
11 Tumor Necrosis Factor in Patients Undergoing Surgery for Primary Cancer or Metastatic Cancer Completed NCT00436410 Early Phase 1

Search NIH Clinical Center for Breast Fibrosarcoma

Genetic Tests for Breast Fibrosarcoma

Anatomical Context for Breast Fibrosarcoma

MalaCards organs/tissues related to Breast Fibrosarcoma:

39
Breast, Liver

Publications for Breast Fibrosarcoma

Articles related to Breast Fibrosarcoma:

id Title Authors Year
1
A young woman with a giant breast fibrosarcoma: a case report. ( 24255792 )
2013
2
Lower extremity acute ischaemia due to a metastatic breast fibrosarcoma embolism. ( 7813736 )
1994

Variations for Breast Fibrosarcoma

Expression for Breast Fibrosarcoma

Search GEO for disease gene expression data for Breast Fibrosarcoma.

Pathways for Breast Fibrosarcoma

Pathways related to Breast Fibrosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.72 CALB1 STIM1

GO Terms for Breast Fibrosarcoma

Cellular components related to Breast Fibrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.16 CALB1 PVALB
2 axon GO:0030424 8.96 CALB1 PVALB
3 terminal bouton GO:0043195 8.62 CALB1 PVALB

Biological processes related to Breast Fibrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of cytosolic calcium ion concentration GO:0051480 8.62 CALB1 PVALB

Molecular functions related to Breast Fibrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 8.8 CALB1 PVALB STIM1

Sources for Breast Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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