MCID: BRS015
MIFTS: 32

Breast Medullary Carcinoma malady

Cancer diseases, Immune diseases categories

Summaries for Breast Medullary Carcinoma

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Medullary breast carcinoma is a rare type of breast cancer that often can be treated successfully. It is... more...

MalaCards: Breast Medullary Carcinoma, also known as medullary breast carcinoma with lymphoid stroma, is related to goblet cell carcinoid and tubular adenocarcinoma. An important gene associated with Breast Medullary Carcinoma is CDH1 (cadherin 1, type 1, E-cadherin (epithelial)), and among its related pathways are Integrated Breast Cancer Pathway and Hippo signaling pathway. The compounds chlorophyllin and cyclopamine have been mentioned in the context of this disorder. Affiliated tissues include breast.

Aliases & Classifications for Breast Medullary Carcinoma

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Sources:
9Disease Ontology, 41NCIt, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

breast medullary carcinoma 9
medullary breast carcinoma with lymphoid stroma 9


External Ids:

Disease Ontology9 DOID:5605
NCIt41 C9119

Related Diseases for Breast Medullary Carcinoma

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of diseases related to Breast Medullary Carcinoma:



Diseases related to breast medullary carcinoma

Symptoms for Breast Medullary Carcinoma

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Drugs & Therapeutics for Breast Medullary Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Breast Medullary Carcinoma

Drug clinical trials:

Search ClinicalTrials for Breast Medullary Carcinoma

Search NIH Clinical Center for Breast Medullary Carcinoma

Search CenterWatch for Breast Medullary Carcinoma

Genetic Tests for Breast Medullary Carcinoma

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Anatomical Context for Breast Medullary Carcinoma

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Sources:
34MalaCards
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MalaCards organs/tissues related to Breast Medullary Carcinoma:

34
Breast

Animal Models for Breast Medullary Carcinoma or affiliated genes

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Publications for Breast Medullary Carcinoma

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Sources:
53PubMed
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Articles related to Breast Medullary Carcinoma:

idTitleAuthorsYear
1
Immunoglobulin repertoire of B lymphocytes infiltrating breast medullary carcinoma. (15156099)
2003
2
A scFv phage display mini library generated from the immunoglobulin repertoire of breast medullary carcinoma infiltrating B lymphocytes. (11360824)
2000
3
E-cadherin and beta-catenin expression in breast medullary carcinomas. (10402239)
1999
4
Immunoglobulin variable regions usage by B-lymphocytes infiltrating a human breast medullary carcinoma. (10065736)
1999

Variations for Breast Medullary Carcinoma

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Expression for genes affiliated with Breast Medullary Carcinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Medullary Carcinoma

Search GEO for disease gene expression data for Breast Medullary Carcinoma.

Pathways for genes affiliated with Breast Medullary Carcinoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 61Thomson Reuters, 56Reactome, 55R&D Systems, 13EMD Millipore, 58SinoBiological, 5Cell Signaling Technology
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Pathways related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CTNNB1, CDH1
29.1CTNNB1, CDH1
3
Show member pathways
Signaling Pathways in Glioblastoma39
9.1CTNNB1, CDH1
49.1CDH1, CTNNB1
5
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
9.1CTNNB1, CDH1
6
Show member pathways
9.1CTNNB1, CDH1
79.1CDH1, CTNNB1
8
Show member pathways
Wnt Signaling Pathway NetPath39
9.1CDH1, CTNNB1
99.1CTNNB1, CDH1
10
Show member pathways
9.1CTNNB1, CDH1
11
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
9.1CTNNB1, CDH1
12
Show member pathways
9.1CTNNB1, CDH1
13
Show member pathways
9.1CTNNB1, CDH1
149.1CDH1, CTNNB1
15
Show member pathways
9.1CTNNB1, CDH1
16
Show member pathways
9.1CTNNB1, CDH1
17
Show member pathways
Signal transduction PTEN pathway61
9.1CTNNB1, CDH1
18
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion61
Pathogenic Escherichia coli infection39
9.1CDH1, CTNNB1
199.1CTNNB1, CDH1
20
Show member pathways
9.1CTNNB1, CDH1
219.1CTNNB1, CDH1
229.1CDH1, CTNNB1
239.1CDH1, CTNNB1
249.1CTNNB1, CDH1
259.1CTNNB1, CDH1
269.1CDH1, CTNNB1
279.1CTNNB1, CDH1
289.1CTNNB1, CDH1
299.1CTNNB1, CDH1
309.1CTNNB1, CDH1
31
Show member pathways
RAC1 signaling pathway39
9.1CDH1, CTNNB1
329.1CTNNB1, CDH1
339.1CTNNB1, CDH1
349.1CDH1, CTNNB1
359.1CTNNB1, CDH1

Compounds for genes affiliated with Breast Medullary Carcinoma

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Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 25HMDB, 30IUPHAR, 52PharmGKB
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Compounds related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1chlorophyllin469.6CTNNB1, CDH1
2cyclopamine46 6210.6CTNNB1, CDH1
3exisulind469.6CTNNB1, CDH1
4sodium bisulfite469.6CDH1, CTNNB1
5etodolac46 1210.6CTNNB1, CDH1
6gamma-linolenic acid46 2510.6CTNNB1, CDH1
7dfmo46 30 6211.6CDH1, CTNNB1
8crcs469.6CTNNB1, CDH1
9indole-3-carbinol469.6CTNNB1, CDH1
10sulindac46 1210.6CDH1, CTNNB1
11methylcellulose469.6CTNNB1, CDH1
12acetaldehyde30 46 2511.6CTNNB1, CDH1
13leptomycin b46 6210.6CDH1, CTNNB1
14celecoxib46 62 30 52 25 1214.5CTNNB1, CDH1
15gefitinib46 52 1211.5CTNNB1, CDH1
16geldanamycin46 52 62 1212.5CTNNB1, CDH1
17nocodazole46 1210.5CDH1, CTNNB1
18p002469.5CTNNB1, CDH1
19mannitol46 1210.5CTNNB1, CDH1
20verapamil46 30 52 25 1213.5CDH1, CTNNB1
21adriamycin469.5CTNNB1, CDH1
22cytochalasin d46 6210.5CTNNB1, CDH1
23egcg469.5CDH1, CTNNB1
24dihydrotestosterone46 30 25 1212.5CTNNB1, CDH1
25mg 13246 6210.5CTNNB1, CDH1
26tgf beta1469.5CDH1, CTNNB1
27herbimycin a46 6210.5CTNNB1, CDH1
28curcumin469.5CTNNB1, CDH1
295-aza-2deoxycytidine469.5CDH1, CTNNB1
30sucrose46 25 1211.5CTNNB1, CDH1
31aspirin46 52 30 2512.5CTNNB1, CDH1
325fluorouracil469.5CDH1, CTNNB1
33agar469.5CTNNB1, CDH1
34retinoid469.4CTNNB1, CDH1
35matrigel469.4CDH1, CTNNB1
36phosphotyrosine469.4CTNNB1, CDH1
37n acetylcysteine469.4CTNNB1, CDH1
38sb 20358046 6210.4CDH1, CTNNB1
39butyrate469.4CTNNB1, CDH1
40tamoxifen46 52 30 1212.4CTNNB1, CDH1
41vitamin d469.4CDH1, CTNNB1
42paclitaxel46 52 1211.3CTNNB1, CDH1
43histamine46 30 2511.3CTNNB1, CDH1
44rapamycin469.3CDH1, CTNNB1
45pd 98,059469.2CTNNB1, CDH1
46ly294002469.2CTNNB1, CDH1
47wortmannin469.1CDH1, CTNNB1
48paraffin469.1CTNNB1, CDH1
49doxorubicin46 52 1211.0CTNNB1, CDH1
50glycogen46 259.8CTNNB1, CDH1

GO Terms for genes affiliated with Breast Medullary Carcinoma

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Sources:
17Gene Ontology
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Cellular components related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.3CTNNB1, CDH1
2cell-cell adherens junctionGO:0059139.3CTNNB1, CDH1
3cytoplasmic side of plasma membraneGO:0098989.2CTNNB1, CDH1
4lateral plasma membraneGO:0163289.2CTNNB1, CDH1
5apical part of cellGO:0451779.1CDH1, CTNNB1
6perinuclear region of cytoplasmGO:0484719.1CTNNB1, CDH1
7basolateral plasma membraneGO:0163239.0CTNNB1, CDH1
8cell junctionGO:0300548.8CTNNB1, CDH1

Biological processes related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to indole-3-methanolGO:0716819.3CTNNB1, CDH1
2regulation of protein localization to cell surfaceGO:20000089.2CTNNB1, CDH1
3cellular component disassembly involved in execution phase of apoptosisGO:0069219.2CTNNB1, CDH1
4cell-cell adhesionGO:0163379.1CDH1, CTNNB1
5apoptotic processGO:0069159.1CTNNB1, CDH1
6response to drugGO:0424939.0CTNNB1, CDH1
7positive regulation of transcription, DNA-templatedGO:0458938.8CTNNB1, CDH1

Molecular functions related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.1CTNNB1, CDH1

Products for genes affiliated with Breast Medullary Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Breast Medullary Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet