MCID: BRS015
MIFTS: 32

Breast Medullary Carcinoma malady

Cancer diseases, Immune diseases categories
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Summaries for Breast Medullary Carcinoma

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Wikipedia:65 Medullary breast carcinoma is a rare type of breast cancer that often can be treated successfully. It is... more...

MalaCards based summary: Breast Medullary Carcinoma, also known as medullary breast carcinoma with lymphoid stroma, is related to goblet cell carcinoid and tubular adenocarcinoma. An important gene associated with Breast Medullary Carcinoma is CDH1 (cadherin 1, type 1, E-cadherin (epithelial)), and among its related pathways are Integrated Breast Cancer Pathway and Hippo signaling pathway. The compounds chlorophyllin and cyclopamine have been mentioned in the context of this disorder. Affiliated tissues include breast.

Aliases & Classifications for Breast Medullary Carcinoma

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Breast Medullary Carcinoma, Aliases & Descriptions:

Name: Breast Medullary Carcinoma 8
 
Medullary Breast Carcinoma with Lymphoid Stroma 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:5605
NCIt39 C9119

Related Diseases for Breast Medullary Carcinoma

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Graphical network of diseases related to Breast Medullary Carcinoma:



Diseases related to breast medullary carcinoma

Symptoms for Breast Medullary Carcinoma

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Drugs & Therapeutics for Breast Medullary Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Breast Medullary Carcinoma

Search NIH Clinical Center for Breast Medullary Carcinoma

Genetic Tests for Breast Medullary Carcinoma

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Anatomical Context for Breast Medullary Carcinoma

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MalaCards organs/tissues related to Breast Medullary Carcinoma:

32
Breast

Animal Models for Breast Medullary Carcinoma or affiliated genes

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Publications for Breast Medullary Carcinoma

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Articles related to Breast Medullary Carcinoma:

idTitleAuthorsYear
1
Immunoglobulin repertoire of B lymphocytes infiltrating breast medullary carcinoma. (15156099)
2003
2
A scFv phage display mini library generated from the immunoglobulin repertoire of breast medullary carcinoma infiltrating B lymphocytes. (11360824)
2000
3
E-cadherin and beta-catenin expression in breast medullary carcinomas. (10402239)
1999
4
Immunoglobulin variable regions usage by B-lymphocytes infiltrating a human breast medullary carcinoma. (10065736)
1999

Variations for Breast Medullary Carcinoma

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Expression for genes affiliated with Breast Medullary Carcinoma

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Expression patterns in normal tissues for genes affiliated with Breast Medullary Carcinoma

Search GEO for disease gene expression data for Breast Medullary Carcinoma.

Pathways for genes affiliated with Breast Medullary Carcinoma

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Pathways related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CTNNB1, CDH1
29.1CTNNB1, CDH1
3
Show member pathways
Signaling Pathways in Glioblastoma37
9.1CTNNB1, CDH1
49.1CDH1, CTNNB1
5
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.1CTNNB1, CDH1
6
Show member pathways
9.1CTNNB1, CDH1
79.1CDH1, CTNNB1
8
Show member pathways
Wnt Signaling Pathway NetPath37
9.1CDH1, CTNNB1
99.1CTNNB1, CDH1
10
Show member pathways
9.1CTNNB1, CDH1
11
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
9.1CTNNB1, CDH1
12
Show member pathways
9.1CTNNB1, CDH1
13
Show member pathways
9.1CTNNB1, CDH1
149.1CDH1, CTNNB1
15
Show member pathways
9.1CTNNB1, CDH1
16
Show member pathways
9.1CTNNB1, CDH1
17
Show member pathways
Signal transduction PTEN pathway60
9.1CTNNB1, CDH1
18
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection37
9.1CDH1, CTNNB1
199.1CTNNB1, CDH1
20
Show member pathways
9.1CTNNB1, CDH1
219.1CTNNB1, CDH1
229.1CDH1, CTNNB1
239.1CDH1, CTNNB1
249.1CTNNB1, CDH1
259.1CTNNB1, CDH1
269.1CDH1, CTNNB1
279.1CTNNB1, CDH1
289.1CTNNB1, CDH1
299.1CTNNB1, CDH1
309.1CTNNB1, CDH1
31
Show member pathways
RAC1 signaling pathway37
9.1CDH1, CTNNB1
329.1CTNNB1, CDH1
339.1CTNNB1, CDH1
349.1CDH1, CTNNB1
359.1CTNNB1, CDH1

Compounds for genes affiliated with Breast Medullary Carcinoma

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Compounds related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1chlorophyllin449.6CTNNB1, CDH1
2cyclopamine44 6110.6CTNNB1, CDH1
3exisulind449.6CTNNB1, CDH1
4sodium bisulfite449.6CDH1, CTNNB1
5etodolac44 1110.6CTNNB1, CDH1
6gamma-linolenic acid44 2410.6CTNNB1, CDH1
7dfmo44 28 6111.6CDH1, CTNNB1
8crcs449.6CTNNB1, CDH1
9indole-3-carbinol449.6CTNNB1, CDH1
10sulindac44 1110.6CDH1, CTNNB1
11methylcellulose449.6CTNNB1, CDH1
12acetaldehyde28 44 2411.6CTNNB1, CDH1
13leptomycin b44 6110.6CDH1, CTNNB1
14celecoxib44 61 28 50 24 1114.5CTNNB1, CDH1
15gefitinib44 50 1111.5CTNNB1, CDH1
16geldanamycin44 50 61 1112.5CTNNB1, CDH1
17nocodazole44 1110.5CDH1, CTNNB1
18p002449.5CTNNB1, CDH1
19mannitol44 1110.5CTNNB1, CDH1
20verapamil44 28 50 24 1113.5CDH1, CTNNB1
21adriamycin449.5CTNNB1, CDH1
22cytochalasin d44 6110.5CTNNB1, CDH1
23egcg449.5CDH1, CTNNB1
24dihydrotestosterone44 28 24 1112.5CTNNB1, CDH1
25mg 13244 6110.5CTNNB1, CDH1
26tgf beta1449.5CDH1, CTNNB1
27herbimycin a44 6110.5CTNNB1, CDH1
28curcumin449.5CTNNB1, CDH1
295-aza-2deoxycytidine449.5CDH1, CTNNB1
30sucrose44 24 1111.5CTNNB1, CDH1
31aspirin44 50 28 2412.5CTNNB1, CDH1
325fluorouracil449.5CDH1, CTNNB1
33agar449.5CTNNB1, CDH1
34retinoid449.4CTNNB1, CDH1
35matrigel449.4CDH1, CTNNB1
36phosphotyrosine449.4CTNNB1, CDH1
37n acetylcysteine449.4CTNNB1, CDH1
38sb 20358044 6110.4CDH1, CTNNB1
39butyrate449.4CTNNB1, CDH1
40tamoxifen44 50 28 1112.4CTNNB1, CDH1
41vitamin d449.4CDH1, CTNNB1
42paclitaxel44 50 1111.3CTNNB1, CDH1
43histamine44 28 2411.3CTNNB1, CDH1
44rapamycin449.3CDH1, CTNNB1
45pd 98,059449.2CTNNB1, CDH1
46ly294002449.2CTNNB1, CDH1
47wortmannin449.1CDH1, CTNNB1
48paraffin449.1CTNNB1, CDH1
49doxorubicin44 50 1111.0CTNNB1, CDH1
50glycogen44 249.8CTNNB1, CDH1

GO Terms for genes affiliated with Breast Medullary Carcinoma

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Cellular components related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.3CTNNB1, CDH1
2cell-cell adherens junctionGO:0059139.3CTNNB1, CDH1
3cytoplasmic side of plasma membraneGO:0098989.2CTNNB1, CDH1
4lateral plasma membraneGO:0163289.2CTNNB1, CDH1
5apical part of cellGO:0451779.1CDH1, CTNNB1
6perinuclear region of cytoplasmGO:0484719.1CTNNB1, CDH1
7basolateral plasma membraneGO:0163239.0CTNNB1, CDH1
8cell junctionGO:0300548.8CTNNB1, CDH1

Biological processes related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to indole-3-methanolGO:0716819.3CTNNB1, CDH1
2regulation of protein localization to cell surfaceGO:20000089.2CTNNB1, CDH1
3cellular component disassembly involved in execution phase of apoptosisGO:0069219.2CTNNB1, CDH1
4cell-cell adhesionGO:0163379.1CDH1, CTNNB1
5apoptotic processGO:0069159.1CTNNB1, CDH1
6response to drugGO:0424939.0CTNNB1, CDH1
7positive regulation of transcription, DNA-templatedGO:0458938.8CTNNB1, CDH1

Molecular functions related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.1CTNNB1, CDH1

Products for genes affiliated with Breast Medullary Carcinoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Breast Medullary Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet