MCID: BRS015
MIFTS: 31

Breast Medullary Carcinoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Breast Medullary Carcinoma

MalaCards integrated aliases for Breast Medullary Carcinoma:

Name: Breast Medullary Carcinoma 12 14
Medullary Breast Carcinoma with Lymphoid Stroma 12
Medullary Carcinoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5605
NCIt 46 C9119
UMLS 69 C0860580

Summaries for Breast Medullary Carcinoma

MalaCards based summary : Breast Medullary Carcinoma, also known as medullary breast carcinoma with lymphoid stroma, is related to lymphocytic gastritis and choriocarcinoma of the testis. An important gene associated with Breast Medullary Carcinoma is GZMB (Granzyme B), and among its related pathways/superpathways are Development HGF signaling pathway and Gastric cancer. Affiliated tissues include breast, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Breast Medullary Carcinoma

Diseases related to Breast Medullary Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 lymphocytic gastritis 10.3 FASLG GZMB
2 choriocarcinoma of the testis 10.3 FASLG GZMB
3 lymphomatoid papulosis 10.3 FASLG GZMB
4 t-cell large granular lymphocyte leukemia 10.2 FASLG GZMB
5 erythema multiforme 10.2 FASLG GZMB
6 sialolithiasis 10.2 FASLG GZMB
7 acute graft versus host disease 10.2 FASLG GZMB
8 b-cell expansion with nfkb and t-cell anergy 10.2 FASLG GZMB
9 comedo carcinoma 10.2 ERBB2 ESR1
10 severe cutaneous adverse reaction 10.1 FASLG GZMB
11 tuberculous salpingitis 10.1 BRCA1 ERBB2
12 uterine corpus serous adenocarcinoma 10.1 BRCA1 ERBB2
13 hidradenocarcinoma 10.1 ERBB2 ESR1
14 fallopian tube adenocarcinoma 10.1 BRCA1 ERBB2
15 alopecia areata 10.1 FASLG GZMB
16 graft-versus-host disease 10.0 FASLG GZMB
17 cervical adenocarcinoma 10.0 ERBB2 ESR1
18 scirrhous adenocarcinoma 10.0 ERBB2 PGR
19 breast apocrine carcinoma 10.0 ERBB2 PGR
20 vulvar syringoma 10.0 ESR1 PGR
21 vestibular gland benign neoplasm 10.0 ESR1 PGR
22 lung leiomyoma 10.0 ESR1 PGR
23 bartholin's gland adenoma 10.0 ESR1 PGR
24 vulvar benign neoplasm 10.0 ESR1 PGR
25 trigonitis 10.0 ESR1 PGR
26 vulvar leiomyoma 9.9 ESR1 PGR
27 intracystic papillary adenoma 9.9 ERBB2 PGR
28 predominantly cortical thymoma 9.9 ESR1 PGR
29 progesterone-receptor negative breast cancer 9.9 ERBB2 PGR
30 progesterone resistance 9.9 ESR1 PGR
31 cribriform carcinoma 9.9 ESR1 PGR
32 bartholin's gland benign neoplasm 9.9 ESR1 PGR
33 endometrial squamous cell carcinoma 9.9 ESR1 PGR
34 gastric signet ring cell adenocarcinoma 9.9 ESR1 PGR
35 endometrial mucinous adenocarcinoma 9.9 ESR1 PGR
36 adenoid basal cell carcinoma 9.9 ESR1 PGR
37 deep angioma 9.9 ESR1 PGR
38 gender identity disorder 9.9 ESR1 PGR
39 cervical carcinosarcoma 9.9 ESR1 PGR
40 uterine body mixed cancer 9.9 ERBB2 PGR
41 breast squamous cell carcinoma 9.9 ERBB2 PGR
42 intramuscular hemangioma 9.9 ESR1 PGR
43 estrogen excess 9.9 ESR1 PGR
44 mammographic density 9.9 ESR1 PGR
45 retinitis pigmentosa 47 9.9 ESR1 PGR
46 microglandular adenosis 9.9 ERBB2 PGR
47 adenomyosis 9.9 ESR1 PGR
48 retinitis pigmentosa 20 9.9 ESR1 PGR
49 adenosarcoma 9.9 ESR1 PGR
50 cervical clear cell adenocarcinoma 9.9 ESR1 PGR

Graphical network of the top 20 diseases related to Breast Medullary Carcinoma:



Diseases related to Breast Medullary Carcinoma

Symptoms & Phenotypes for Breast Medullary Carcinoma

MGI Mouse Phenotypes related to Breast Medullary Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.88 ESR1 BRCA1 FASLG ERBB2 PGR
2 endocrine/exocrine gland MP:0005379 9.83 BRCA1 FASLG ERBB2 PGR ESR1
3 integument MP:0010771 9.8 BRCA1 FASLG ERBB2 PGR ESR1
4 digestive/alimentary MP:0005381 9.76 ESR1 BRCA1 FASLG ERBB2
5 neoplasm MP:0002006 9.72 BRCA1 FASLG ERBB2 PGR ESR1
6 limbs/digits/tail MP:0005371 9.67 ESR1 BRCA1 ERBB2 PGR
7 normal MP:0002873 9.65 BRCA1 FASLG ERBB2 PGR ESR1
8 reproductive system MP:0005389 9.55 BRCA1 FASLG ERBB2 PGR ESR1
9 respiratory system MP:0005388 9.26 ESR1 BRCA1 FASLG ERBB2
10 skeleton MP:0005390 9.02 BRCA1 FASLG ERBB2 PGR ESR1

Drugs & Therapeutics for Breast Medullary Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Medullary Carcinoma

Genetic Tests for Breast Medullary Carcinoma

Anatomical Context for Breast Medullary Carcinoma

MalaCards organs/tissues related to Breast Medullary Carcinoma:

38
Breast

Publications for Breast Medullary Carcinoma

Articles related to Breast Medullary Carcinoma:

# Title Authors Year
1
Immunoglobulin repertoire of B lymphocytes infiltrating breast medullary carcinoma. ( 15156099 )
2003
2
A scFv phage display mini library generated from the immunoglobulin repertoire of breast medullary carcinoma infiltrating B lymphocytes. ( 11360824 )
2000
3
E-cadherin and beta-catenin expression in breast medullary carcinomas. ( 10402239 )
1999
4
Immunoglobulin variable regions usage by B-lymphocytes infiltrating a human breast medullary carcinoma. ( 10065736 )
1999

Variations for Breast Medullary Carcinoma

Cosmic variations for Breast Medullary Carcinoma:

9 (show all 19)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM775 PIK3CA breast,NS,carcinoma,medullary c.3140A>G p.H1047R 12
2 COSM763 PIK3CA breast,NS,carcinoma,medullary c.1633G>A p.E545K 12
3 COSM10654 TP53 breast,NS,carcinoma,medullary carcinoma c.637C>T p.R213* 11
4 COSM10834 TP53 breast,NS,carcinoma,medullary carcinoma c.711G>A p.M237I 11
5 COSM10648 TP53 breast,NS,carcinoma,medullary carcinoma c.524G>A p.R175H 11
6 COSM43947 TP53 breast,NS,carcinoma,medullary carcinoma c.614A>G p.Y205C 11
7 COSM10646 TP53 breast,NS,carcinoma,medullary carcinoma c.725G>A p.C242Y 11
8 COSM10662 TP53 breast,NS,carcinoma,medullary carcinoma c.743G>A p.R248Q 11
9 COSM10728 TP53 breast,NS,carcinoma,medullary carcinoma c.839G>A p.R280K 11
10 COSM10742 TP53 breast,NS,carcinoma,medullary carcinoma c.578A>G p.H193R 11
11 COSM10731 TP53 breast,NS,carcinoma,medullary carcinoma c.707A>G p.Y236C 11
12 COSM44687 TP53 breast,NS,carcinoma,medullary carcinoma c.379T>C p.S127P 11
13 COSM10758 TP53 breast,NS,carcinoma,medullary carcinoma c.659A>G p.Y220C 11
14 COSM11286 TP53 breast,NS,carcinoma,medullary carcinoma c.1015G>T p.E339* 11
15 COSM10667 TP53 breast,NS,carcinoma,medullary carcinoma c.646G>A p.V216M 11
16 COSM10893 TP53 breast,NS,carcinoma,medullary carcinoma c.824G>A p.C275Y 11
17 COSM11089 TP53 breast,NS,carcinoma,medullary carcinoma c.584T>C p.I195T 11
18 COSM11148 TP53 breast,NS,carcinoma,medullary carcinoma c.476C>T p.A159V 11
19 COSM10726 TP53 breast,NS,carcinoma,medullary carcinoma c.856G>A p.E286K 11

Expression for Breast Medullary Carcinoma

Search GEO for disease gene expression data for Breast Medullary Carcinoma.

Pathways for Breast Medullary Carcinoma

Pathways related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 ERBB2 ESR1 FASLG
2
Show member pathways
12.12 BRCA1 ERBB2 ESR1 PGR
3 11.81 ERBB2 ESR1 FASLG
4
Show member pathways
11.68 BRCA1 ESR1 PGR
5 11.33 BRCA1 ERBB2
6
Show member pathways
11.26 FASLG GZMB
7 11.24 BRCA1 ERBB2
8
Show member pathways
11.17 ERBB2 ESR1 PGR
9 11.14 BRCA1 FASLG
10
Show member pathways
11.07 BRCA1 ESR1
11
Show member pathways
10.92 FASLG GZMB
12 10.66 BRCA1 ERBB2 FASLG

GO Terms for Breast Medullary Carcinoma

Biological processes related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.55 BRCA1 ERBB2 ESR1 FASLG PGR
2 transcription, DNA-templated GO:0006351 9.35 BRCA1 ERBB2 ESR1 FASLG PGR
3 response to estrogen GO:0043627 9.32 BRCA1 ESR1
4 steroid hormone mediated signaling pathway GO:0043401 9.26 ESR1 PGR
5 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 8.62 BRCA1 FASLG

Molecular functions related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.33 BRCA1 ESR1 PGR
2 ATPase binding GO:0051117 9.32 ESR1 PGR
3 steroid hormone receptor activity GO:0003707 9.26 ESR1 PGR
4 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
5 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Breast Medullary Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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