MCID: BRS015
MIFTS: 32

Breast Medullary Carcinoma malady

Cancer diseases, Immune diseases categories
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Summaries for Breast Medullary Carcinoma

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Medullary breast carcinoma is a rare type of breast cancer that often can be treated successfully. It is... more...

MalaCards: Breast Medullary Carcinoma, also known as medullary breast carcinoma with lymphoid stroma, is related to goblet cell carcinoid and tubular adenocarcinoma. An important gene associated with Breast Medullary Carcinoma is CDH1 (cadherin 1, type 1, E-cadherin (epithelial)), and among its related pathways are Integrated Breast Cancer Pathway and Hippo signaling pathway. The compounds chlorophyllin and cyclopamine have been mentioned in the context of this disorder. Affiliated tissues include breast.

Aliases & Classifications for Breast Medullary Carcinoma

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Sources:
8Disease Ontology, 40NCIt, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

breast medullary carcinoma 8
medullary breast carcinoma with lymphoid stroma 8


External Ids:

Disease Ontology8 DOID:5605
NCIt40 C9119

Related Diseases for Breast Medullary Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Breast Medullary Carcinoma:



Diseases related to breast medullary carcinoma

Symptoms for Breast Medullary Carcinoma

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Drugs & Therapeutics for Breast Medullary Carcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Breast Medullary Carcinoma

Search NIH Clinical Center for Breast Medullary Carcinoma

Genetic Tests for Breast Medullary Carcinoma

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Anatomical Context for Breast Medullary Carcinoma

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Sources:
33MalaCards
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MalaCards organs/tissues related to Breast Medullary Carcinoma:

33
Breast

Animal Models for Breast Medullary Carcinoma or affiliated genes

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Publications for Breast Medullary Carcinoma

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Sources:
52PubMed
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Articles related to Breast Medullary Carcinoma:

idTitleAuthorsYear
1
Immunoglobulin repertoire of B lymphocytes infiltrating breast medullary carcinoma. (15156099)
2003
2
A scFv phage display mini library generated from the immunoglobulin repertoire of breast medullary carcinoma infiltrating B lymphocytes. (11360824)
2000
3
E-cadherin and beta-catenin expression in breast medullary carcinomas. (10402239)
1999
4
Immunoglobulin variable regions usage by B-lymphocytes infiltrating a human breast medullary carcinoma. (10065736)
1999

Variations for Breast Medullary Carcinoma

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Expression for genes affiliated with Breast Medullary Carcinoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Medullary Carcinoma

Search GEO for disease gene expression data for Breast Medullary Carcinoma.

Pathways for genes affiliated with Breast Medullary Carcinoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 60Thomson Reuters, 55Reactome, 54R&D Systems, 12EMD Millipore, 57SinoBiological, 5Cell Signaling Technology
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Pathways related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1CTNNB1, CDH1
29.1CTNNB1, CDH1
3
Show member pathways
Signaling Pathways in Glioblastoma38
9.1CTNNB1, CDH1
49.1CDH1, CTNNB1
5
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.1CTNNB1, CDH1
6
Show member pathways
9.1CTNNB1, CDH1
79.1CDH1, CTNNB1
8
Show member pathways
Wnt Signaling Pathway NetPath38
9.1CDH1, CTNNB1
99.1CTNNB1, CDH1
10
Show member pathways
9.1CTNNB1, CDH1
11
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
9.1CTNNB1, CDH1
12
Show member pathways
9.1CTNNB1, CDH1
13
Show member pathways
9.1CTNNB1, CDH1
149.1CDH1, CTNNB1
15
Show member pathways
9.1CTNNB1, CDH1
16
Show member pathways
9.1CTNNB1, CDH1
17
Show member pathways
Signal transduction PTEN pathway60
9.1CTNNB1, CDH1
18
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection38
9.1CDH1, CTNNB1
199.1CTNNB1, CDH1
20
Show member pathways
9.1CTNNB1, CDH1
219.1CTNNB1, CDH1
229.1CDH1, CTNNB1
239.1CDH1, CTNNB1
249.1CTNNB1, CDH1
259.1CTNNB1, CDH1
269.1CDH1, CTNNB1
279.1CTNNB1, CDH1
289.1CTNNB1, CDH1
299.1CTNNB1, CDH1
309.1CTNNB1, CDH1
31
Show member pathways
RAC1 signaling pathway38
9.1CDH1, CTNNB1
329.1CTNNB1, CDH1
339.1CTNNB1, CDH1
349.1CDH1, CTNNB1
359.1CTNNB1, CDH1

Compounds for genes affiliated with Breast Medullary Carcinoma

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Sources:
45Novoseek, 61Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 51PharmGKB
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Compounds related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1chlorophyllin459.6CTNNB1, CDH1
2cyclopamine45 6110.6CTNNB1, CDH1
3exisulind459.6CTNNB1, CDH1
4sodium bisulfite459.6CDH1, CTNNB1
5etodolac45 1110.6CTNNB1, CDH1
6gamma-linolenic acid45 2410.6CTNNB1, CDH1
7dfmo45 29 6111.6CDH1, CTNNB1
8crcs459.6CTNNB1, CDH1
9indole-3-carbinol459.6CTNNB1, CDH1
10sulindac45 1110.6CDH1, CTNNB1
11methylcellulose459.6CTNNB1, CDH1
12acetaldehyde29 45 2411.6CTNNB1, CDH1
13leptomycin b45 6110.6CDH1, CTNNB1
14celecoxib45 61 29 51 24 1114.5CTNNB1, CDH1
15gefitinib45 51 1111.5CTNNB1, CDH1
16geldanamycin45 51 61 1112.5CTNNB1, CDH1
17nocodazole45 1110.5CDH1, CTNNB1
18p002459.5CTNNB1, CDH1
19mannitol45 1110.5CTNNB1, CDH1
20verapamil45 29 51 24 1113.5CDH1, CTNNB1
21adriamycin459.5CTNNB1, CDH1
22cytochalasin d45 6110.5CTNNB1, CDH1
23egcg459.5CDH1, CTNNB1
24dihydrotestosterone45 29 24 1112.5CTNNB1, CDH1
25mg 13245 6110.5CTNNB1, CDH1
26tgf beta1459.5CDH1, CTNNB1
27herbimycin a45 6110.5CTNNB1, CDH1
28curcumin459.5CTNNB1, CDH1
295-aza-2deoxycytidine459.5CDH1, CTNNB1
30sucrose45 24 1111.5CTNNB1, CDH1
31aspirin45 51 29 2412.5CTNNB1, CDH1
325fluorouracil459.5CDH1, CTNNB1
33agar459.5CTNNB1, CDH1
34retinoid459.4CTNNB1, CDH1
35matrigel459.4CDH1, CTNNB1
36phosphotyrosine459.4CTNNB1, CDH1
37n acetylcysteine459.4CTNNB1, CDH1
38sb 20358045 6110.4CDH1, CTNNB1
39butyrate459.4CTNNB1, CDH1
40tamoxifen45 51 29 1112.4CTNNB1, CDH1
41vitamin d459.4CDH1, CTNNB1
42paclitaxel45 51 1111.3CTNNB1, CDH1
43histamine45 29 2411.3CTNNB1, CDH1
44rapamycin459.3CDH1, CTNNB1
45pd 98,059459.2CTNNB1, CDH1
46ly294002459.2CTNNB1, CDH1
47wortmannin459.1CDH1, CTNNB1
48paraffin459.1CTNNB1, CDH1
49doxorubicin45 51 1111.0CTNNB1, CDH1
50glycogen45 249.8CTNNB1, CDH1

GO Terms for genes affiliated with Breast Medullary Carcinoma

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Sources:
16Gene Ontology
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Cellular components related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.3CTNNB1, CDH1
2cell-cell adherens junctionGO:0059139.3CTNNB1, CDH1
3cytoplasmic side of plasma membraneGO:0098989.2CTNNB1, CDH1
4lateral plasma membraneGO:0163289.2CTNNB1, CDH1
5apical part of cellGO:0451779.1CDH1, CTNNB1
6perinuclear region of cytoplasmGO:0484719.1CTNNB1, CDH1
7basolateral plasma membraneGO:0163239.0CTNNB1, CDH1
8cell junctionGO:0300548.8CTNNB1, CDH1

Biological processes related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to indole-3-methanolGO:0716819.3CTNNB1, CDH1
2regulation of protein localization to cell surfaceGO:20000089.2CTNNB1, CDH1
3cellular component disassembly involved in execution phase of apoptosisGO:0069219.2CTNNB1, CDH1
4cell-cell adhesionGO:0163379.1CDH1, CTNNB1
5apoptotic processGO:0069159.1CTNNB1, CDH1
6response to drugGO:0424939.0CTNNB1, CDH1
7positive regulation of transcription, DNA-templatedGO:0458938.8CTNNB1, CDH1

Molecular functions related to Breast Medullary Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.1CTNNB1, CDH1

Products for genes affiliated with Breast Medullary Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Breast Medullary Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet