MCID: BRS031
MIFTS: 22

Breast Rhabdomyosarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Rhabdomyosarcoma

MalaCards integrated aliases for Breast Rhabdomyosarcoma:

Name: Breast Rhabdomyosarcoma 12 14 69
Rhabdomyosarcoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4060
NCIt 46 C5190
UMLS 69 C1332637

Summaries for Breast Rhabdomyosarcoma

MalaCards based summary : Breast Rhabdomyosarcoma, also known as rhabdomyosarcoma of the breast, is related to rhabdomyosarcoma and pseudosarcomatous fibromatosis. An important gene associated with Breast Rhabdomyosarcoma is DES (Desmin), and among its related pathways/superpathways are Immune response Function of MEF2 in T lymphocytes and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include breast, and related phenotype is muscle.

Related Diseases for Breast Rhabdomyosarcoma

Diseases related to Breast Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 rhabdomyosarcoma 28.3 DES MB MYOD1 MYOG
2 pseudosarcomatous fibromatosis 10.0 DES MYOG
3 orbit rhabdomyosarcoma 10.0 MB MYOG
4 giant cell myocarditis 10.0 DES MB
5 myofibroma 10.0 DES MB
6 bilateral retinoblastoma 10.0 DES MB
7 adenosarcoma 10.0 DES MB
8 infantile myofibromatosis 10.0 DES MB
9 uterine sarcoma 9.9 DES MB
10 glomangioma 9.9 DES MB
11 cervical polyp 9.9 DES MYOD1
12 undifferentiated embryonal sarcoma of the liver 9.9 MYOD1 MYOG
13 conventional leiomyosarcoma 9.8 MYOD1 MYOG
14 horner's syndrome 9.8 DES MYOD1
15 malignant fibrous histiocytoma of bone 9.8 DES MYOD1
16 spindle cell liposarcoma 9.8 MYOD1 MYOG
17 nephrogenic adenofibroma 9.8 MYOD1 MYOG
18 liposarcoma 9.8 DES MB
19 malignant fibroxanthoma 9.8 DES MYOD1
20 pleomorphic rhabdomyosarcoma 9.8 MB MYOD1
21 extraosseous ewing's sarcoma 9.7 MYOD1 MYOG
22 endometrial stromal sarcoma 9.7 DES MB
23 muscle tissue disease 9.6 MB MYOD1
24 leiomyosarcoma 9.6 DES MB MYOG
25 histiocytoma 9.6 MB MYOD1
26 gallbladder sarcoma 9.5 DES MYOD1 MYOG
27 muscular dystrophy, duchenne type 9.5 MB MYOD1
28 inflammatory leiomyosarcoma 9.5 DES MYOD1 MYOG
29 embryonal sarcoma 9.5 DES MYOD1 MYOG
30 desmoplastic small round cell tumor 9.5 DES MYOD1 MYOG
31 malignant triton tumor 9.4 DES MB MYOD1
32 mesenchymoma 9.4 DES MB MYOD1
33 spindle cell rhabdomyosarcoma 9.4 DES MB MYOD1
34 adult fibrosarcoma 9.4 MB MYOD1 MYOG
35 rhabdoid cancer 9.4 DES MB MYOD1
36 skeletal muscle cancer 9.4 MB MYOD1 MYOG
37 alveolar soft part sarcoma 9.4 DES MB MYOD1
38 ewing sarcoma 9.3 DES MYOD1 MYOG
39 myositis 9.3 MB MYOD1
40 myopathy 9.2 DES MB MYOD1
41 medullomyoblastoma 9.1 DES MB MYOD1 MYOG
42 botryoid rhabdomyosarcoma 9.1 DES MB MYOD1 MYOG
43 malignant mesenchymoma 9.1 DES MB MYOD1 MYOG
44 muscle cancer 9.1 DES MB MYOD1 MYOG
45 embryonal rhabdomyosarcoma 9.1 DES MB MYOD1 MYOG
46 rhabdomyosarcoma 2 9.1 DES MB MYOD1 MYOG

Graphical network of the top 20 diseases related to Breast Rhabdomyosarcoma:



Diseases related to Breast Rhabdomyosarcoma

Symptoms & Phenotypes for Breast Rhabdomyosarcoma

MGI Mouse Phenotypes related to Breast Rhabdomyosarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 DES MB MYOD1 MYOG

Drugs & Therapeutics for Breast Rhabdomyosarcoma

Search Clinical Trials , NIH Clinical Center for Breast Rhabdomyosarcoma

Genetic Tests for Breast Rhabdomyosarcoma

Anatomical Context for Breast Rhabdomyosarcoma

MalaCards organs/tissues related to Breast Rhabdomyosarcoma:

38
Breast

Publications for Breast Rhabdomyosarcoma

Articles related to Breast Rhabdomyosarcoma:

# Title Authors Year
1
Fatal breast rhabdomyosarcoma in a 15 year old primigravida. ( 2379516 )
1990
2
Cytology of fine needle aspiration biopsy of primary breast rhabdomyosarcoma in an adolescent girl. ( 3859144 )
1985

Variations for Breast Rhabdomyosarcoma

Expression for Breast Rhabdomyosarcoma

Search GEO for disease gene expression data for Breast Rhabdomyosarcoma.

Pathways for Breast Rhabdomyosarcoma

Pathways related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.3 MYOD1 MYOG
2 10.78 DES MYOD1 MYOG
3
Show member pathways
10.72 MYOD1 MYOG

GO Terms for Breast Rhabdomyosarcoma

Cellular components related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.62 MYOD1 MYOG

Biological processes related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cellular response to tumor necrosis factor GO:0071356 9.52 MYOD1 MYOG
2 muscle organ development GO:0007517 9.51 MYOD1 MYOG
3 skeletal muscle tissue development GO:0007519 9.49 MYOD1 MYOG
4 skeletal muscle cell differentiation GO:0035914 9.48 MYOD1 MYOG
5 cellular response to estradiol stimulus GO:0071392 9.46 MYOD1 MYOG
6 skeletal muscle fiber development GO:0048741 9.43 MYOD1 MYOG
7 positive regulation of muscle cell differentiation GO:0051149 9.4 MYOD1 MYOG
8 positive regulation of myoblast differentiation GO:0045663 9.37 MYOD1 MYOG
9 myoblast differentiation GO:0045445 9.32 MYOD1 MYOG
10 positive regulation of myoblast fusion GO:1901741 9.26 MYOD1 MYOG
11 myotube differentiation GO:0014902 9.16 MYOD1 MYOG
12 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOD1 MYOG
13 muscle cell fate commitment GO:0042693 8.62 MYOD1 MYOG

Molecular functions related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein dimerization activity GO:0046983 9.37 MYOD1 MYOG
2 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 9.32 MYOD1 MYOG
3 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.26 MYOD1 MYOG
4 core promoter binding GO:0001047 9.16 MYOD1 MYOG
5 chromatin DNA binding GO:0031490 8.96 MYOD1 MYOG
6 E-box binding GO:0070888 8.62 MYOD1 MYOG

Sources for Breast Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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