MCID: BRS061
MIFTS: 29

Breast Sarcoma malady

Cancer diseases category
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Summaries for Breast Sarcoma

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33MalaCards
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MalaCards: Breast Sarcoma, also known as sarcoma of breast, is related to sarcoma and breast osteosarcoma. An important gene associated with Breast Sarcoma is ITGA4 (integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)), and among its related pathways are Akt Signaling and Apoptotic Pathways in Synovial Fibroblasts. The compounds hydroxyurea and vincristine have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and brain, and related mouse phenotype craniofacial.

Aliases & Classifications for Breast Sarcoma

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Sources:
8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

breast sarcoma 8
sarcoma of breast 8 62


External Ids:

Disease Ontology8 DOID:3017
SNOMED-CT58 278050001
NCIt40 C4670

Related Diseases for Breast Sarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Breast Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.1ITGA4, TP53
2breast osteosarcoma10.1
3spindle cell sarcoma10.1
4breast angiosarcoma10.1
5fibrous histiocytoma10.1
6histiocytoma10.1
7multiple myeloma10.0TP53, ITGA4
8rhabdomyosarcoma10.0TP53, ITGA4
9b-cell lymphomas10.0TP53, ITGA4
10intussusception10.0
11li-fraumeni syndrome10.0
12breast cancer10.0
13astrocytoma10.0ITGA4, TP53
14osteosarcoma10.0ITGA4, TP53
15stomach cancer10.0ITGA4, TP53
16burkitt's lymphoma10.0TP53, ITGA4
17leukemia10.0TP53, ITGA4
18tongue squamous cell carcinoma10.0ITGA4, TP53
19melanoma9.9TP53, ITGA4

Graphical network of diseases related to Breast Sarcoma:



Diseases related to breast sarcoma

Symptoms for Breast Sarcoma

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Drugs & Therapeutics for Breast Sarcoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Breast Sarcoma

Search NIH Clinical Center for Breast Sarcoma

Genetic Tests for Breast Sarcoma

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Anatomical Context for Breast Sarcoma

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Sources:
33MalaCards
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MalaCards organs/tissues related to Breast Sarcoma:

33
Breast, Lymph node, Brain

Animal Models for Breast Sarcoma or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Breast Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.1ITGA4, TP53

Publications for Breast Sarcoma

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52PubMed
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Articles related to Breast Sarcoma:

(show all 35)
idTitleAuthorsYear
1
Breast sarcoma. (23552541)
2013
2
Breast sarcoma after breast-conserving therapy for breast cancer in a patient with Li-Fraumeni syndrome presenting as focal nonmasslike enhancement on MRI. (24261401)
2013
3
Breast sarcoma in a pregnant patient A case report. (23070281)
2012
4
The CD49d+/high subpopulation from isolated human breast sarcoma spheres possesses tumor-initiating ability. (22159714)
2012
5
Imaging features of primary breast sarcoma. (22451578)
2012
6
Primary breast sarcoma: prevalence, clinical signs, and radiological features. (21565891)
2011
7
Treatment for breast sarcoma: a large, single-centre series. (21628089)
2011
8
Diagnosis and management of primary breast sarcoma. (20480227)
2010
9
Breast sarcoma--a review of diagnosis and management. (19114317)
2009
10
Primary breast sarcoma. (18514698)
2008
11
Treatment and outcomes of patients with primary breast sarcoma. (18723152)
2008
12
Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network. (18023492)
2007
13
Good outcome after neoadjuvant chemotherapy and extended surgical resection for a large radiation-induced high-grade breast sarcoma. (16824232)
2006
14
Report on a case of breast sarcoma metastatic to the axillary lymph nodes. (16724703)
2006
15
A rare case of breast sarcoma brain metastases. (15925991)
2005
16
Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. (15187996)
2004
17
Primary breast sarcoma: case report. (15490711)
2004
18
Breast sarcoma showing myofibroblastic differentiation. (12844261)
2003
19
Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres. (12956895)
2003
20
An unusual case of metastatic post-irradiation breast sarcoma. (14965694)
2002
21
P53 expression is a factor for prognostic assessment in breast sarcoma. (12002339)
2002
22
Radiation-induced breast sarcoma. (12383902)
2002
23
Surgical management of primary breast sarcoma. (12206600)
2002
24
An analysis of 78 breast sarcoma patients without distant metastases at presentation. (10661345)
2000
25
F-18 FDG whole-body positron emission tomography scan in primary breast sarcoma. (9735983)
1998
26
Breast sarcoma. (8610270)
1996
27
Human breast sarcoma and human breast implantation: a time trend analysis based on SEER data (1973-1990). (7722610)
1995
28
Breast sarcoma. A clinicopathologic review of 25 cases. (2386920)
1990
29
Primary breast sarcoma: a review of 33 cases with immunohistochemistry and prognostic factors. (2468372)
1989
30
Breast sarcoma with giant cells and osteoid. (3166604)
1988
31
Breast sarcoma. (3674288)
1987
32
Breast sarcoma with giant cells and osteoid. A case report and review of the literature. (3826481)
1987
33
A breast sarcoma containing rhabdomyosarcomatous and other metaplastic elements. (4099010)
1970
34
Results of 22 cases of breast sarcoma over five years after surgery. (4316262)
1970
35
Recurrent intussusception in an adult, due to intestinal metastases of a breast sarcoma. (13811295)
1959

Variations for Breast Sarcoma

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Expression for genes affiliated with Breast Sarcoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Breast Sarcoma

Search GEO for disease gene expression data for Breast Sarcoma.

Pathways for genes affiliated with Breast Sarcoma

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Sources:
50PathCards, 53QIAGEN, 55Reactome, 61Tocris Bioscience, 30KEGG
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Compounds for genes affiliated with Breast Sarcoma

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Breast Sarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hydroxyurea45 51 1111.2ITGA4, TP53
2vincristine45 51 1111.2ITGA4, TP53
3cyclophosphamide45 51 1111.1ITGA4, TP53
4retinoic acid45 2410.1ITGA4, TP53
5butyrate459.0TP53, ITGA4
6cycloheximide458.8ITGA4, TP53

GO Terms for genes affiliated with Breast Sarcoma

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16Gene Ontology
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Biological processes related to Breast Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075969.1ITGA4, TP53

Products for genes affiliated with Breast Sarcoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Breast Sarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet