MCID: BRS061
MIFTS: 28

Breast Sarcoma malady

Categories: Cancer diseases

Aliases & Classifications for Breast Sarcoma

Aliases & Descriptions for Breast Sarcoma:

Name: Breast Sarcoma 12 14
Sarcoma of Breast 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3017
NCIt 47 C4670
SNOMED-CT 64 278050001
UMLS 69 C0349667

Summaries for Breast Sarcoma

Disease Ontology : 12 A breast cancer that has material basis in abnormally proliferating cells derives from mesenchymal cells.

MalaCards based summary : Breast Sarcoma, also known as sarcoma of breast, is related to breast osteosarcoma and breast angiosarcoma. An important gene associated with Breast Sarcoma is TCF20 (Transcription Factor 20). The drugs Carboplatin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and brain, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Related Diseases for Breast Sarcoma

Diseases related to Breast Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 breast osteosarcoma 10.8
2 breast angiosarcoma 10.8
3 sarcoma 10.3
4 breast cancer 9.5
5 li-fraumeni syndrome 9.5
6 dermatofibrosarcoma protuberans 9.5
7 intussusception 9.5
8 skin angiosarcoma 9.4 ANGPTL8 HBA1 NDUFS2 SCN8A
9 colon mucinous adenocarcinoma 8.9 ANGPTL8 HBA1 ITGA4 NDUFS2 SCN8A TCF20

Graphical network of the top 20 diseases related to Breast Sarcoma:



Diseases related to Breast Sarcoma

Symptoms & Phenotypes for Breast Sarcoma

GenomeRNAi Phenotypes related to Breast Sarcoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.23 ITGA4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.23 ITGA4
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.23 ITGA4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.23 ITGA4
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.23 HBA1 ITGA4
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.23 HBA1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.23 HBA1

Drugs & Therapeutics for Breast Sarcoma

Drugs for Breast Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 256)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
2
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
3
Mechlorethamine Approved Phase 3,Phase 2,Phase 1 51-75-2 4033
4
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
5
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
6
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 6857599, 9887054 43805
7
Cyclophosphamide Approved, Investigational Phase 2, Phase 3, Phase 1 50-18-0, 6055-19-2 2907
8
Trastuzumab Approved, Investigational Phase 2, Phase 3 180288-69-1 9903
9
Gemcitabine Approved Phase 3,Phase 2,Phase 1 95058-81-4 60750
10
Cetuximab Approved Phase 3,Phase 1,Phase 2 205923-56-4 56842117 2333
11
Irinotecan Approved, Investigational Phase 3,Phase 1,Phase 2 97682-44-5, 100286-90-6 60838
12
Levoleucovorin Approved Phase 3,Phase 1,Phase 2 68538-85-2
13
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
14
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
15
Morphine Approved, Investigational Phase 3 57-27-2 5288826
16
Epirubicin Approved Phase 2, Phase 3,Phase 1 56420-45-2 41867
17
Doxorubicin Approved, Investigational Phase 2, Phase 3, Phase 1 23214-92-8 31703
18
Etoposide Approved Phase 3,Phase 1 33419-42-0 36462
19
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
20
Pertuzumab Approved Phase 2, Phase 3 145040-37-5, 380610-27-5 2540
21
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
23
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
24
Melatonin Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 73-31-4 896
25
Dehydroepiandrosterone Approved, Nutraceutical Phase 3 53-43-0 9860744
26
Docetaxel Approved May 1996, Investigational Phase 2, Phase 3, Phase 1 114977-28-5 148124 9877265
27
Camptothecin Experimental Phase 3,Phase 1 7689-03-4
28
Doxil Approved June 1999 Phase 2, Phase 3, Phase 1 31703
29 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
30 Alkylating Agents Phase 3,Phase 2,Phase 1
31 Antimitotic Agents Phase 3,Phase 2,Phase 1
32 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
33 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
34 Isophosphamide mustard Phase 3,Phase 2,Phase 1
35 Antibodies Phase 3,Phase 1,Phase 2
36 Antibodies, Monoclonal Phase 3,Phase 1,Phase 2
37 Antimetabolites Phase 3,Phase 2,Phase 1
38 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
39 Immunoglobulins Phase 3,Phase 1,Phase 2
40 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
41 Micronutrients Phase 3,Phase 2,Phase 1
42 Trace Elements Phase 3,Phase 2,Phase 1
43 Vitamin B Complex Phase 3,Phase 2,Phase 1
44 Vitamins Phase 3,Phase 2,Phase 1
45 Analgesics Phase 3,Phase 1,Phase 2
46 Liver Extracts Phase 3,Phase 1,Phase 2,Early Phase 1
47 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2
48 Antirheumatic Agents Phase 3,Phase 1,Phase 2
49 Anti-Infective Agents Phase 3,Phase 2,Phase 1
50 Antiviral Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 195)
id Name Status NCT ID Phase
1 Paclitaxel and Carboplatin or Ifosfamide in Treating Patients With Newly Diagnosed Persistent or Recurrent Uterine, Ovarian, Fallopian Tube, or Peritoneal Cavity Cancer Unknown status NCT00954174 Phase 3
2 Chemotherapy Drug Sensitivity Microculture (MiCK) Assay for Apoptosis Completed NCT00243685 Phase 2, Phase 3
3 Melatonin In Reduction of Chemotherapy-Induced Toxicity (MIRCIT) Trial Completed NCT01706627 Phase 2, Phase 3
4 Comparison of Combination Chemotherapy Regimens With or Without Cetuximab in Treating Patients Who Have Undergone Surgery For Stage III Colon Cancer Completed NCT00079274 Phase 3
5 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
6 E-MOSAIC Electronic Tool to Monitor Symptoms Completed NCT00477919 Phase 3
7 An Analysis of the Response of Human Tumor Microvascular Endothelium to Ionizing Radiation Completed NCT00132704 Phase 3
8 Neoadjuvant Response-guided Treatment of HER2 Positive Breast Cancer Recruiting NCT02568839 Phase 2, Phase 3
9 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
10 Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Recruiting NCT02306161 Phase 3
11 Gemcitabine Hydrochloride and Docetaxel Followed by Doxorubicin Hydrochloride or Observation in Treating Patients With High-Risk Uterine Leiomyosarcoma Previously Removed by Surgery Recruiting NCT01533207 Phase 3
12 Study Comparing the Safety and Effectiveness of Magnetic Resonance Guided Focused Ultrasound (MRgFUS) and External Beam Radiation (EBRT) for Treatment of Metastatic Bone Tumors and Multiple Myeloma Recruiting NCT01091883 Phase 3
13 Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms Active, not recruiting NCT01376349 Phase 3
14 Fish Oil Versus Statins Versus Placebos in Reducing Atrial Fibrillation in Patients Undergoing Thoracic Surgery for Lung Cancer Terminated NCT01259284 Phase 2, Phase 3
15 Sorafenib and Paclitaxel in Treating Patients With Metastatic Breast Cancer Unknown status NCT00622466 Phase 2
16 Combination Therapy of F16IL2 and Paclitaxel in Solid Tumour Patients Unknown status NCT01134250 Phase 1, Phase 2
17 Dendritic Cell Vaccination for Patients With Solid Tumors Unknown status NCT01291420 Phase 1, Phase 2
18 FLO +/- Pazopanib as First-line Treatment in Advanced Gastric Cancer Unknown status NCT01503372 Phase 2
19 Biweekly Gemcitabine and Docetaxel as First Line Therapy for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Unknown status NCT00906061 Phase 2
20 Phase 1-2 Study of Onapristone in Patients With Progesterone Receptor Expressing Cancers Unknown status NCT02052128 Phase 1, Phase 2
21 Continuous Temozolomide in Patients With Advanced or Metastatic Soft Tissue Sarcoma or Metastatic Breast Cancer Completed NCT00194766 Phase 2
22 Safety and Efficacy Study Using Rexin-G for Breast Cancer Completed NCT00505271 Phase 1, Phase 2
23 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2
24 Rucaparib(CO-338;Formally Called AG-014699 or PF-0136738) in Treating Patients With Locally Advanced or Metastatic Breast Cancer or Advanced Ovarian Cancer Completed NCT00664781 Phase 2
25 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
26 Phase I/II Study of Escalating-Dose Melphalan w/Autologous SCS & Amifostine Cytoprotect Completed NCT00003425 Phase 1, Phase 2
27 Phase 2 Study of HM10460A or Pegfilgrastim Use for the Management of Neutropenia in Breast Cancer Patients Completed NCT01724866 Phase 2
28 Magnetic-Targeted Doxorubicin in Treating Patients With Cancer Metastatic to the Liver Completed NCT00041808 Phase 1, Phase 2
29 Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases Completed NCT00587964 Phase 2
30 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
31 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2
32 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
33 Letrozole in Women With Advanced Estrogen/Progesterone Receptor Positive Uterine Leiomyosarcoma Completed NCT00856050 Phase 2
34 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2
35 Reproducibility of 18F Uptake by Solid Tumors Using PET Imaging Following Intravenous Administration of (18F) Injection Completed NCT00918281 Phase 2
36 A Study to Assess the Potential Effects of a Single-Dose Administration of Trabectedin on the QT Intervals of the Electrocardiogram Completed NCT00786838 Phase 2
37 A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1 Completed NCT00948961 Phase 1, Phase 2
38 Focused Ultrasound Surgery in the Treatment of Pain Resulting From Metastatic Bone Tumors With the ExAblate 2100 Conformal Bone System Completed NCT01085565 Phase 2
39 Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes Completed NCT00171912 Phase 2
40 Eribulin Mesylate in Treating Patients With Recurrent or Refractory Osteosarcoma Completed NCT02097238 Phase 2
41 Neoadjuvant Response-guided Treatment of Luminal B-type Tumors and Luminal A-type Tumors With Node Metastases Recruiting NCT02603679 Phase 2
42 Neoadjuvant Response-guided Treatment of Slowly Proliferating Hormone Receptor Positive Tumors Recruiting NCT02592083 Phase 2
43 A Study of Metronomic CP and JX-594 in Patients With Advanced Breast Cancer and Advanced Soft-tissue Sarcoma (METROmaJX) Recruiting NCT02630368 Phase 1, Phase 2
44 Pilot Study of Liposomal Doxorubicin Combined With Bevacizumab Followed by Bevacizumab Monotherapy in Adults With Advanced Kaposi s Sarcoma Recruiting NCT00923936 Phase 2
45 Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer Recruiting NCT01764802 Phase 2
46 Study of Pembrolizumab Plus Chemotherapy in Patients With Advanced Cancer (PembroPlus) Recruiting NCT02331251 Phase 1, Phase 2
47 Study of Abemaciclib in Dedifferentiated Liposarcoma Recruiting NCT02846987 Phase 2
48 Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma Recruiting NCT02601209 Phase 1, Phase 2
49 T Cell Receptor Immunotherapy Targeting NY-ESO-1 for Patients With NY-ESO-1 Expressing Cancer Recruiting NCT01967823 Phase 2
50 Phase II Trial of Combination Immunotherapy With NeuVax and Trastuzumab in High-risk HER2+ Breast Cancer Patients Recruiting NCT02297698 Phase 2

Search NIH Clinical Center for Breast Sarcoma

Genetic Tests for Breast Sarcoma

Anatomical Context for Breast Sarcoma

MalaCards organs/tissues related to Breast Sarcoma:

39
Breast, Lymph Node, Brain

Publications for Breast Sarcoma

Articles related to Breast Sarcoma:

(show all 42)
id Title Authors Year
1
Management of Breast Sarcoma. ( 27542642 )
2016
2
Breast sarcoma. A case report and review of literature. ( 27281361 )
2016
3
Primary female breast sarcoma: clinicopathological features, treatment and prognosis. ( 27510467 )
2016
4
Primary breast sarcoma: A retrospective study over 35 years from a single institution. ( 26586158 )
2016
5
Early Local Recurrence Presents Adverse Effect on Outcomes of Primary Breast Sarcoma: A Retrospective Study From Single Institute in China. ( 26735546 )
2016
6
Breast sarcoma: a rare malignancy. ( 24965425 )
2014
7
Spontaneous Perforation as a First Presentation of Ileal Gastrointestinal Stromal Tumour (GIST) with Synchronous Breast Sarcoma. ( 24995213 )
2014
8
Breast sarcoma after breast-conserving therapy for breast cancer in a patient with Li-Fraumeni syndrome presenting as focal nonmasslike enhancement on MRI. ( 24261401 )
2013
9
Breast sarcoma. ( 23552541 )
2013
10
Imaging features of primary breast sarcoma. ( 22451578 )
2012
11
Breast sarcoma in a pregnant patient A case report. ( 23070281 )
2012
12
The CD49d+/high subpopulation from isolated human breast sarcoma spheres possesses tumor-initiating ability. ( 22159714 )
2012
13
Primary breast sarcoma: prevalence, clinical signs, and radiological features. ( 21565891 )
2011
14
Treatment for breast sarcoma: a large, single-centre series. ( 21628089 )
2011
15
Diagnosis and management of primary breast sarcoma. ( 20480227 )
2010
16
Breast sarcoma--a review of diagnosis and management. ( 19114317 )
2009
17
Primary breast sarcoma. ( 18514698 )
2008
18
Treatment and outcomes of patients with primary breast sarcoma. ( 18723152 )
2008
19
Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network. ( 18023492 )
2007
20
Report on a case of breast sarcoma metastatic to the axillary lymph nodes. ( 16724703 )
2006
21
Good outcome after neoadjuvant chemotherapy and extended surgical resection for a large radiation-induced high-grade breast sarcoma. ( 16824232 )
2006
22
A rare case of breast sarcoma brain metastases. ( 15925991 )
2005
23
Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. ( 15187996 )
2004
24
Primary breast sarcoma: case report. ( 15490711 )
2004
25
Breast sarcoma showing myofibroblastic differentiation. ( 12844261 )
2003
26
Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres. ( 12956895 )
2003
27
P53 expression is a factor for prognostic assessment in breast sarcoma. ( 12002339 )
2002
28
An unusual case of metastatic post-irradiation breast sarcoma. ( 14965694 )
2002
29
Surgical management of primary breast sarcoma. ( 12206600 )
2002
30
Radiation-induced breast sarcoma. ( 12383902 )
2002
31
An analysis of 78 breast sarcoma patients without distant metastases at presentation. ( 10661345 )
2000
32
F-18 FDG whole-body positron emission tomography scan in primary breast sarcoma. ( 9735983 )
1998
33
Breast sarcoma. ( 8610270 )
1996
34
Human breast sarcoma and human breast implantation: a time trend analysis based on SEER data (1973-1990). ( 7722610 )
1995
35
Breast sarcoma. A clinicopathologic review of 25 cases. ( 2386920 )
1990
36
Primary breast sarcoma: a review of 33 cases with immunohistochemistry and prognostic factors. ( 2468372 )
1989
37
Breast sarcoma with giant cells and osteoid. ( 3166604 )
1988
38
Breast sarcoma. ( 3674288 )
1987
39
Breast sarcoma with giant cells and osteoid. A case report and review of the literature. ( 3826481 )
1987
40
A breast sarcoma containing rhabdomyosarcomatous and other metaplastic elements. ( 4099010 )
1970
41
Results of 22 cases of breast sarcoma over five years after surgery. ( 4316262 )
1970
42
Recurrent intussusception in an adult, due to intestinal metastases of a breast sarcoma. ( 13811295 )
1959

Variations for Breast Sarcoma

Expression for Breast Sarcoma

Search GEO for disease gene expression data for Breast Sarcoma.

Pathways for Breast Sarcoma

GO Terms for Breast Sarcoma

Sources for Breast Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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