MCID: BRS061
MIFTS: 26

Breast Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Sarcoma

MalaCards integrated aliases for Breast Sarcoma:

Name: Breast Sarcoma 12 14
Sarcoma of Breast 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3017
NCIt 46 C4670
SNOMED-CT 64 278050001
UMLS 69 C0349667

Summaries for Breast Sarcoma

Disease Ontology : 12 A breast cancer that has material basis in abnormally proliferating cells derives from mesenchymal cells.

MalaCards based summary : Breast Sarcoma, also known as sarcoma of breast, is related to breast angiosarcoma and breast osteosarcoma. An important gene associated with Breast Sarcoma is ITGA4 (Integrin Subunit Alpha 4). The drugs Adenosine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and lymph node.

Related Diseases for Breast Sarcoma

Diseases related to Breast Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 breast angiosarcoma 29.7 ANGPTL8 HBA1 SCN8A
2 breast osteosarcoma 11.0
3 sarcoma 10.4
4 intussusception 9.6
5 li-fraumeni syndrome 9.6
6 li-fraumeni syndrome 2 9.6

Graphical network of the top 20 diseases related to Breast Sarcoma:



Diseases related to Breast Sarcoma

Symptoms & Phenotypes for Breast Sarcoma

Drugs & Therapeutics for Breast Sarcoma

Drugs for Breast Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adenosine Approved, Investigational Phase 2, Phase 3 58-61-7 60961
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
3
Epirubicin Approved Phase 2, Phase 3 56420-45-2 41867
4
Pertuzumab Approved Phase 2, Phase 3 380610-27-5, 145040-37-5 2540
5
Trastuzumab Approved, Investigational Phase 2, Phase 3 180288-69-1 9903
6
Docetaxel Approved May 1996, Investigational Phase 2, Phase 3 114977-28-5 148124 9877265
7 Ado-trastuzumab emtansine Phase 2, Phase 3
8 Antimitotic Agents Phase 2, Phase 3
9
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
10
Exemestane Approved, Investigational Phase 2 107868-30-4 60198
11
Goserelin Approved Phase 2 65807-02-5 5311128 47725
12
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
13
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
14
Palbociclib Approved, Investigational Phase 2 571190-30-2 5330286 11431660 5005498
15
Phenobarbital Approved, Investigational Phase 2 50-06-6 4763
16
Tamoxifen Approved Phase 2 10540-29-1 2733526
17 Albumin-Bound Paclitaxel Phase 2
18 Anticonvulsants Phase 2
19 Antineoplastic Agents, Hormonal Phase 2
20 Antineoplastic Agents, Phytogenic Phase 2
21 Aromatase Inhibitors Phase 2
22 Bone Density Conservation Agents Phase 2
23 Central Nervous System Depressants Phase 2
24 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
25 Cytochrome P-450 CYP3A Inducers Phase 2
26 Estrogen Antagonists Phase 2
27 Estrogen Receptor Modulators Phase 2
28 Estrogens Phase 2
29 Excitatory Amino Acid Antagonists Phase 2
30 Excitatory Amino Acids Phase 2
31 GABA Agents Phase 2
32 GABA Modulators Phase 2
33 Hormone Antagonists Phase 2
34 Hormones Phase 2
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
36 Hypnotics and Sedatives Phase 2
37 Neurotransmitter Agents Phase 2
38 Protein Kinase Inhibitors Phase 2
39 Selective Estrogen Receptor Modulators Phase 2
40 Steroid Synthesis Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neoadjuvant Response-guided Treatment of HER2 Positive Breast Cancer Recruiting NCT02568839 Phase 2, Phase 3 docetaxel + trastuzumab sc + pertuzumab;trastuzumab emtansin
2 Neoadjuvant Response-guided Treatment of Luminal B-type Tumors and Luminal A-type Tumors With Node Metastases Recruiting NCT02603679 Phase 2 Paclitaxel;Tamoxifen + Palbociclib;Aromatase Inhibitor + Palbociclib;Goserelin + Aromatase Inhibitor + Palbociclib
3 Neoadjuvant Response-guided Treatment of Slowly Proliferating Hormone Receptor Positive Tumors Recruiting NCT02592083 Phase 2 Tamoxifen or Aromatase Inhibitor or Aromatase Inhibitor + goserelin;Palbociclib

Search NIH Clinical Center for Breast Sarcoma

Genetic Tests for Breast Sarcoma

Anatomical Context for Breast Sarcoma

MalaCards organs/tissues related to Breast Sarcoma:

38
Breast, Bone, Lymph Node, Brain

Publications for Breast Sarcoma

Articles related to Breast Sarcoma:

(show all 44)
# Title Authors Year
1
Imaging findings of primary breast sarcoma: Results of a first multicenter study. ( 28189193 )
2017
2
Early Local Recurrence Presents Adverse Effect on Outcomes of Primary Breast Sarcoma: A Retrospective Study From Single Institute in China. ( 26735546 )
2016
3
Breast sarcoma. A case report and review of literature. ( 27281361 )
2016
4
Management of Breast Sarcoma. ( 27542642 )
2016
5
A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report. ( 28101028 )
2016
6
Primary female breast sarcoma: clinicopathological features, treatment and prognosis. ( 27510467 )
2016
7
Primary breast sarcoma: A retrospective study over 35 years from a single institution. ( 26586158 )
2016
8
Spontaneous Perforation as a First Presentation of Ileal Gastrointestinal Stromal Tumour (GIST) with Synchronous Breast Sarcoma. ( 24995213 )
2014
9
Breast sarcoma: a rare malignancy. ( 24965425 )
2014
10
Breast sarcoma. ( 23552541 )
2013
11
Breast sarcoma after breast-conserving therapy for breast cancer in a patient with Li-Fraumeni syndrome presenting as focal nonmasslike enhancement on MRI. ( 24261401 )
2013
12
Imaging features of primary breast sarcoma. ( 22451578 )
2012
13
The CD49d+/high subpopulation from isolated human breast sarcoma spheres possesses tumor-initiating ability. ( 22159714 )
2012
14
Breast sarcoma in a pregnant patient A case report. ( 23070281 )
2012
15
Treatment for breast sarcoma: a large, single-centre series. ( 21628089 )
2011
16
Primary breast sarcoma: prevalence, clinical signs, and radiological features. ( 21565891 )
2011
17
Diagnosis and management of primary breast sarcoma. ( 20480227 )
2010
18
Breast sarcoma--a review of diagnosis and management. ( 19114317 )
2009
19
Primary breast sarcoma. ( 18514698 )
2008
20
Treatment and outcomes of patients with primary breast sarcoma. ( 18723152 )
2008
21
Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network. ( 18023492 )
2007
22
Good outcome after neoadjuvant chemotherapy and extended surgical resection for a large radiation-induced high-grade breast sarcoma. ( 16824232 )
2006
23
Report on a case of breast sarcoma metastatic to the axillary lymph nodes. ( 16724703 )
2006
24
A rare case of breast sarcoma brain metastases. ( 15925991 )
2005
25
Primary breast sarcoma: case report. ( 15490711 )
2004
26
Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. ( 15187996 )
2004
27
Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres. ( 12956895 )
2003
28
Breast sarcoma showing myofibroblastic differentiation. ( 12844261 )
2003
29
An unusual case of metastatic post-irradiation breast sarcoma. ( 14965694 )
2002
30
Radiation-induced breast sarcoma. ( 12383902 )
2002
31
P53 expression is a factor for prognostic assessment in breast sarcoma. ( 12002339 )
2002
32
Surgical management of primary breast sarcoma. ( 12206600 )
2002
33
An analysis of 78 breast sarcoma patients without distant metastases at presentation. ( 10661345 )
2000
34
F-18 FDG whole-body positron emission tomography scan in primary breast sarcoma. ( 9735983 )
1998
35
Breast sarcoma. ( 8610270 )
1996
36
Human breast sarcoma and human breast implantation: a time trend analysis based on SEER data (1973-1990). ( 7722610 )
1995
37
Breast sarcoma. A clinicopathologic review of 25 cases. ( 2386920 )
1990
38
Primary breast sarcoma: a review of 33 cases with immunohistochemistry and prognostic factors. ( 2468372 )
1989
39
Breast sarcoma with giant cells and osteoid. ( 3166604 )
1988
40
Breast sarcoma. ( 3674288 )
1987
41
Breast sarcoma with giant cells and osteoid. A case report and review of the literature. ( 3826481 )
1987
42
Results of 22 cases of breast sarcoma over five years after surgery. ( 4316262 )
1970
43
A breast sarcoma containing rhabdomyosarcomatous and other metaplastic elements. ( 4099010 )
1970
44
Recurrent intussusception in an adult, due to intestinal metastases of a breast sarcoma. ( 13811295 )
1959

Variations for Breast Sarcoma

Expression for Breast Sarcoma

Search GEO for disease gene expression data for Breast Sarcoma.

Pathways for Breast Sarcoma

GO Terms for Breast Sarcoma

Sources for Breast Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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