MCID: BRS061
MIFTS: 30

Breast Sarcoma malady

Cancer diseases category
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Summaries for Breast Sarcoma

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Disease Ontology:8 A breast cancer that has material basis in abnormally proliferating cells derives from mesenchymal cells.

MalaCards based summary: Breast Sarcoma, also known as sarcoma of breast, is related to sarcoma and breast osteosarcoma. An important gene associated with Breast Sarcoma is ITGA4 (integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)), and among its related pathways are Akt Signaling and Apoptotic Pathways in Synovial Fibroblasts. The compounds hydroxyurea and vincristine have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and brain, and related mouse phenotype craniofacial.

Aliases & Classifications for Breast Sarcoma

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Breast Sarcoma, Aliases & Descriptions:

Name: Breast Sarcoma 8
 
Sarcoma of Breast 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:3017
SNOMED-CT57 278050001
NCIt39 C4670

Related Diseases for Breast Sarcoma

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Diseases related to Breast Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.1ITGA4, TP53
2breast osteosarcoma10.2
3breast angiosarcoma10.1
4fibrous histiocytoma10.1
5spindle cell sarcoma10.1
6histiocytoma10.1
7intussusception10.0
8li-fraumeni syndrome10.0
9breast cancer10.0
10multiple myeloma10.0TP53, ITGA4
11rhabdomyosarcoma10.0TP53, ITGA4
12b-cell lymphomas10.0TP53, ITGA4
13astrocytoma9.9ITGA4, TP53
14osteosarcoma9.9ITGA4, TP53
15stomach cancer9.9ITGA4, TP53
16burkitt's lymphoma9.9TP53, ITGA4
17leukemia9.9TP53, ITGA4
18tongue squamous cell carcinoma9.8ITGA4, TP53
19melanoma9.8TP53, ITGA4

Graphical network of diseases related to Breast Sarcoma:



Diseases related to breast sarcoma

Symptoms for Breast Sarcoma

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Drugs & Therapeutics for Breast Sarcoma

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Drug clinical trials:

Search ClinicalTrials for Breast Sarcoma

Search NIH Clinical Center for Breast Sarcoma

Genetic Tests for Breast Sarcoma

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Anatomical Context for Breast Sarcoma

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MalaCards organs/tissues related to Breast Sarcoma:

32
Breast, Lymph node, Brain

Animal Models for Breast Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Breast Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.1ITGA4, TP53

Publications for Breast Sarcoma

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Articles related to Breast Sarcoma:

(show all 36)
idTitleAuthorsYear
1
Spontaneous Perforation as a First Presentation of Ileal Gastrointestinal Stromal Tumour (GIST) with Synchronous Breast Sarcoma. (24995213)
2014
2
Breast sarcoma: a rare malignancy. (24965425)
2014
3
Breast sarcoma. (23552541)
2013
4
Breast sarcoma after breast-conserving therapy for breast cancer in a patient with Li-Fraumeni syndrome presenting as focal nonmasslike enhancement on MRI. (24261401)
2013
5
Breast sarcoma in a pregnant patient A case report. (23070281)
2012
6
The CD49d+/high subpopulation from isolated human breast sarcoma spheres possesses tumor-initiating ability. (22159714)
2012
7
Imaging features of primary breast sarcoma. (22451578)
2012
8
Primary breast sarcoma: prevalence, clinical signs, and radiological features. (21565891)
2011
9
Treatment for breast sarcoma: a large, single-centre series. (21628089)
2011
10
Diagnosis and management of primary breast sarcoma. (20480227)
2010
11
Breast sarcoma--a review of diagnosis and management. (19114317)
2009
12
Primary breast sarcoma. (18514698)
2008
13
Treatment and outcomes of patients with primary breast sarcoma. (18723152)
2008
14
Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network. (18023492)
2007
15
Good outcome after neoadjuvant chemotherapy and extended surgical resection for a large radiation-induced high-grade breast sarcoma. (16824232)
2006
16
Report on a case of breast sarcoma metastatic to the axillary lymph nodes. (16724703)
2006
17
A rare case of breast sarcoma brain metastases. (15925991)
2005
18
Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. (15187996)
2004
19
Primary breast sarcoma: case report. (15490711)
2004
20
Breast sarcoma showing myofibroblastic differentiation. (12844261)
2003
21
Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres. (12956895)
2003
22
An unusual case of metastatic post-irradiation breast sarcoma. (14965694)
2002
23
P53 expression is a factor for prognostic assessment in breast sarcoma. (12002339)
2002
24
Radiation-induced breast sarcoma. (12383902)
2002
25
Surgical management of primary breast sarcoma. (12206600)
2002
26
An analysis of 78 breast sarcoma patients without distant metastases at presentation. (10661345)
2000
27
F-18 FDG whole-body positron emission tomography scan in primary breast sarcoma. (9735983)
1998
28
Breast sarcoma. (8610270)
1996
29
Human breast sarcoma and human breast implantation: a time trend analysis based on SEER data (1973-1990). (7722610)
1995
30
Breast sarcoma. A clinicopathologic review of 25 cases. (2386920)
1990
31
Primary breast sarcoma: a review of 33 cases with immunohistochemistry and prognostic factors. (2468372)
1989
32
Breast sarcoma with giant cells and osteoid. (3166604)
1988
33
Breast sarcoma. (3674288)
1987
34
Breast sarcoma with giant cells and osteoid. A case report and review of the literature. (3826481)
1987
35
Results of 22 cases of breast sarcoma over five years after surgery. (4316262)
1970
36
Recurrent intussusception in an adult, due to intestinal metastases of a breast sarcoma. (13811295)
1959

Variations for Breast Sarcoma

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Expression for genes affiliated with Breast Sarcoma

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Expression patterns in normal tissues for genes affiliated with Breast Sarcoma

Search GEO for disease gene expression data for Breast Sarcoma.

Pathways for genes affiliated with Breast Sarcoma

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Compounds for genes affiliated with Breast Sarcoma

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Breast Sarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hydroxyurea44 50 1111.2ITGA4, TP53
2vincristine44 50 1111.2ITGA4, TP53
3cyclophosphamide44 50 1111.1ITGA4, TP53
4retinoic acid44 2410.1ITGA4, TP53
5butyrate449.0TP53, ITGA4
6cycloheximide448.8ITGA4, TP53

GO Terms for genes affiliated with Breast Sarcoma

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Biological processes related to Breast Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075969.1ITGA4, TP53

Products for genes affiliated with Breast Sarcoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Breast Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet