MCID: BRS061
MIFTS: 27

Breast Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Sarcoma

MalaCards integrated aliases for Breast Sarcoma:

Name: Breast Sarcoma 12 14
Sarcoma of Breast 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3017
NCIt 47 C4670
SNOMED-CT 64 278050001
UMLS 69 C0349667

Summaries for Breast Sarcoma

Disease Ontology : 12 A breast cancer that has material basis in abnormally proliferating cells derives from mesenchymal cells.

MalaCards based summary : Breast Sarcoma, also known as sarcoma of breast, is related to breast osteosarcoma and breast angiosarcoma. An important gene associated with Breast Sarcoma is ITGA4 (Integrin Subunit Alpha 4). The drugs Fluorouracil and Oxaliplatin have been mentioned in the context of this disorder. Affiliated tissues include breast, t cells and prostate.

Related Diseases for Breast Sarcoma

Diseases related to Breast Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 breast osteosarcoma 10.9
2 breast angiosarcoma 10.8
3 sarcoma 10.3
4 breast cancer 9.5
5 li-fraumeni syndrome 9.5
6 myelophthisic anemia 9.5
7 intussusception 9.5
8 thyroid angiosarcoma 8.9 ANGPTL8 HBA1 SCN8A
9 acinar cell carcinoma 7.2 ANGPTL8 HBA1 ITGA4 SCN8A STIM1 TCF20

Graphical network of the top 20 diseases related to Breast Sarcoma:



Diseases related to Breast Sarcoma

Symptoms & Phenotypes for Breast Sarcoma

Drugs & Therapeutics for Breast Sarcoma

Drugs for Breast Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 228)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
2
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
3
Cyclophosphamide Approved, Investigational Phase 2, Phase 3, Phase 1 50-18-0, 6055-19-2 2907
4
Trastuzumab Approved, Investigational Phase 2, Phase 3 180288-69-1 9903
5
Gemcitabine Approved Phase 3,Phase 2,Phase 1 95058-81-4 60750
6
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
7
Cetuximab Approved Phase 3,Phase 1,Phase 2 205923-56-4 56842117 2333
8
Irinotecan Approved, Investigational Phase 3,Phase 1,Phase 2 97682-44-5, 100286-90-6 60838
9
Levoleucovorin Approved Phase 3,Phase 1,Phase 2 68538-85-2
10
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
11
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
12
Morphine Approved, Investigational Phase 3 57-27-2 5288826
13
Epirubicin Approved Phase 2, Phase 3,Phase 1 56420-45-2 41867
14
Doxorubicin Approved, Investigational Phase 2, Phase 3, Phase 1 23214-92-8 31703
15
Ifosfamide Approved Phase 2, Phase 3, Phase 1 3778-73-2 3690
16
Mechlorethamine Approved Phase 2, Phase 3, Phase 1 51-75-2 4033
17
Etoposide Approved Phase 3,Phase 1 33419-42-0 36462
18
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
19
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
20
Adenosine Approved, Investigational Phase 2, Phase 3,Phase 1 58-61-7 60961
21
Pertuzumab Approved Phase 2, Phase 3 145040-37-5, 380610-27-5 2540
22
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
24
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
25
Melatonin Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 73-31-4 896
26
Dehydroepiandrosterone Approved, Nutraceutical Phase 3 53-43-0 9860744
27
Docetaxel Approved May 1996, Investigational Phase 2, Phase 3, Phase 1 114977-28-5 148124 9877265
28
Camptothecin Experimental Phase 3,Phase 1 7689-03-4
29 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
30
Doxil Approved June 1999 Phase 2, Phase 3, Phase 1 31703
31 Antibodies Phase 3,Phase 1,Phase 2
32 Antibodies, Monoclonal Phase 3,Phase 1,Phase 2
33 Antimetabolites Phase 3,Phase 2,Phase 1
34 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
35 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
36 Immunoglobulins Phase 3,Phase 1,Phase 2
37 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
38 Micronutrients Phase 3,Phase 2,Phase 1
39 Trace Elements Phase 3,Phase 2,Phase 1
40 Vitamin B Complex Phase 3,Phase 2,Phase 1
41 Vitamins Phase 3,Phase 2,Phase 1
42 Analgesics Phase 3,Phase 1,Phase 2
43 Liver Extracts Phase 3,Phase 1,Phase 2,Early Phase 1
44 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2
45 Antimitotic Agents Phase 2, Phase 3, Phase 1
46 Alkylating Agents Phase 2, Phase 3, Phase 1
47 Antirheumatic Agents Phase 3,Phase 1,Phase 2
48 Anti-Infective Agents Phase 3,Phase 2,Phase 1
49 Antiviral Agents Phase 3,Phase 2,Phase 1
50 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 160)

id Name Status NCT ID Phase Drugs
1 Chemotherapy Drug Sensitivity Microculture (MiCK) Assay for Apoptosis Completed NCT00243685 Phase 2, Phase 3
2 Melatonin In Reduction of Chemotherapy-Induced Toxicity (MIRCIT) Trial Completed NCT01706627 Phase 2, Phase 3 10 mg Melatonin;20 mg Melatonin;Matched placebo
3 Comparison of Combination Chemotherapy Regimens With or Without Cetuximab in Treating Patients Who Have Undergone Surgery For Stage III Colon Cancer Completed NCT00079274 Phase 3 irinotecan hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil;Locally Directed Therapy
4 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
5 E-MOSAIC Electronic Tool to Monitor Symptoms Completed NCT00477919 Phase 3
6 Neoadjuvant Response-guided Treatment of HER2 Positive Breast Cancer Recruiting NCT02568839 Phase 2, Phase 3 docetaxel + trastuzumab sc + pertuzumab;trastuzumab emtansin
7 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
8 Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Recruiting NCT02306161 Phase 3 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Vincristine Sulfate
9 Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms Active, not recruiting NCT01376349 Phase 3 prasterone
10 Gemcitabine Hydrochloride and Docetaxel Followed by Doxorubicin Hydrochloride or Observation in Treating Patients With High-Risk Uterine Leiomyosarcoma Previously Removed by Surgery Active, not recruiting NCT01533207 Phase 3 Docetaxel;Doxorubicin Hydrochloride;Gemcitabine Hydrochloride
11 Paclitaxel and Carboplatin or Ifosfamide in Treating Patients With Newly Diagnosed, Persistent or Recurrent Uterine, Ovarian, Fallopian Tube, or Peritoneal Cavity Cancer Active, not recruiting NCT00954174 Phase 3 Carboplatin;Ifosfamide;Paclitaxel
12 Sorafenib and Paclitaxel in Treating Patients With Metastatic Breast Cancer Unknown status NCT00622466 Phase 2 paclitaxel;sorafenib tosylate
13 Combination Therapy of F16IL2 and Paclitaxel in Solid Tumour Patients Unknown status NCT01134250 Phase 1, Phase 2 F16IL2 in combination with paclitaxel
14 Dendritic Cell Vaccination for Patients With Solid Tumors Unknown status NCT01291420 Phase 1, Phase 2
15 FLO +/- Pazopanib as First-line Treatment in Advanced Gastric Cancer Unknown status NCT01503372 Phase 2 Pazopanib;5-FU, Oxaliplatin, Leukovorin (FLO)
16 Biweekly Gemcitabine and Docetaxel as First Line Therapy for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Unknown status NCT00906061 Phase 2 Gemcitabine and Docetaxel
17 Phase 1-2 Study of Onapristone in Patients With Progesterone Receptor Expressing Cancers Unknown status NCT02052128 Phase 1, Phase 2 onapristone
18 Continuous Temozolomide in Patients With Advanced or Metastatic Soft Tissue Sarcoma or Metastatic Breast Cancer Completed NCT00194766 Phase 2 Temozolomide
19 Safety and Efficacy Study Using Rexin-G for Breast Cancer Completed NCT00505271 Phase 1, Phase 2
20 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
21 Rucaparib(CO-338;Formally Called AG-014699 or PF-0136738) in Treating Patients With Locally Advanced or Metastatic Breast Cancer or Advanced Ovarian Cancer Completed NCT00664781 Phase 2 rucaparib (CO-338; formally AG-014699 or PF-01367338)
22 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
23 Phase I/II Study of Escalating-Dose Melphalan w/Autologous SCS & Amifostine Cytoprotect Completed NCT00003425 Phase 1, Phase 2 amifostine trihydrate;cyclophosphamide;melphalan
24 Magnetic-Targeted Doxorubicin in Treating Patients With Cancer Metastatic to the Liver Completed NCT00041808 Phase 1, Phase 2 MTC-DOX for Injection
25 Phase 2 Study of HM10460A or Pegfilgrastim Use for the Management of Neutropenia in Breast Cancer Patients Completed NCT01724866 Phase 2 HM10460A (45 μg/kg);HM10460A (135 μg/kg);HM10460A (270 μg/kg);Pegfilgrastim 6mg
26 Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases Completed NCT00587964 Phase 2
27 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
28 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2 docetaxel
29 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
30 Letrozole in Women With Advanced Estrogen/Progesterone Receptor Positive Uterine Leiomyosarcoma Completed NCT00856050 Phase 2 letrozole
31 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
32 Neoadjuvant Response-guided Treatment of Luminal B-type Tumors and Luminal A-type Tumors With Node Metastases Recruiting NCT02603679 Phase 2 Paclitaxel;Tamoxifen + Palbociclib;Aromatase Inhibitor + Palbociclib;Goserelin + Aromatase Inhibitor + Palbociclib
33 Neoadjuvant Response-guided Treatment of Slowly Proliferating Hormone Receptor Positive Tumors Recruiting NCT02592083 Phase 2 Tamoxifen or Aromatase Inhibitor or Aromatase Inhibitor + goserelin;Palbociclib
34 A Study of Metronomic CP and JX-594 in Patients With Advanced Breast Cancer and Advanced Soft-tissue Sarcoma (METROmaJX) Recruiting NCT02630368 Phase 1, Phase 2 Cyclophosphamide and JX-594 dose escalation;Cyclophosphamide and JX-594;Cyclophosphamide
35 Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer Recruiting NCT01764802 Phase 2
36 Study of Abemaciclib in Dedifferentiated Liposarcoma Recruiting NCT02846987 Phase 2 Abemaciclib
37 Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery Recruiting NCT02500797 Phase 2
38 Phase II Trial of Combination Immunotherapy With NeuVax and Trastuzumab in High-risk HER2+ Breast Cancer Patients Recruiting NCT02297698 Phase 2 Trastuzumab;GM-CSF
39 Combination Immunotherapy With Herceptin and the HER2 Vaccine NeuVax Recruiting NCT01570036 Phase 2 Herceptin;NeuVax vaccine;GM-CSF
40 T Cell Receptor Immunotherapy Targeting NY-ESO-1 for Patients With NY-ESO-1 Expressing Cancer Recruiting NCT01967823 Phase 2 Cyclophosphamide;Fludarabine;Aldesleukin
41 Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) Recruiting NCT02568267 Phase 2 Entrectinib
42 AZD1775 Plus Chemotherapy in Patients With Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Recruiting NCT02272790 Phase 2 AZD1775 + carboplatin;AZD1775 + paclitaxel
43 Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer Recruiting NCT02874430 Phase 2 Metformin Hydrochloride;Doxycycline
44 Study of LOXO-101 (Larotrectinib) in Subjects With NTRK Fusion Positive Solid Tumors (NAVIGATE) Recruiting NCT02576431 Phase 2 LOXO-101
45 Phase 1/2 Study of LOXO-195 in Patients With Previously Treated NTRK Fusions or Non-fusion NTRK Cancers Recruiting NCT03215511 Phase 1, Phase 2 LOXO-195
46 PEN-866 in Patients With Advanced Solid Malignancies Recruiting NCT03221400 Phase 1, Phase 2 PEN-866
47 Thermal Ablation and Stereotactic Spine Radiosurgery (SSRS) Recruiting NCT02713269 Phase 2
48 A Phase 1/2 Study of In Situ Vaccination With Tremelimumab and IV Durvalumab Plus PolyICLC in Subjects With Advanced, Measurable, Biopsy-accessible Cancers Recruiting NCT02643303 Phase 1, Phase 2 Durvalumab;Tremelimumab;Poly ICLC
49 Clinical Trial of Lurbinectedin (PM01183) in Selected Advanced Solid Tumors Recruiting NCT02454972 Phase 2 lurbinectedin (PM01183)
50 Pilot Study of Liposomal Doxorubicin Combined With Bevacizumab Followed by Bevacizumab Monotherapy in Adults With Advanced Kaposi s Sarcoma Active, not recruiting NCT00923936 Phase 2 Liposomal Doxorubicin;Bevacizumab

Search NIH Clinical Center for Breast Sarcoma

Genetic Tests for Breast Sarcoma

Anatomical Context for Breast Sarcoma

MalaCards organs/tissues related to Breast Sarcoma:

39
Breast, T Cells, Prostate, Liver, Bone, Colon, Brain

Publications for Breast Sarcoma

Articles related to Breast Sarcoma:

(show all 44)
id Title Authors Year
1
Imaging findings of primary breast sarcoma: Results of a first multicenter study. ( 28189193 )
2017
2
A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report. ( 28101028 )
2016
3
Primary female breast sarcoma: clinicopathological features, treatment and prognosis. ( 27510467 )
2016
4
Management of Breast Sarcoma. ( 27542642 )
2016
5
Early Local Recurrence Presents Adverse Effect on Outcomes of Primary Breast Sarcoma: A Retrospective Study From Single Institute in China. ( 26735546 )
2016
6
Breast sarcoma. A case report and review of literature. ( 27281361 )
2016
7
Primary breast sarcoma: A retrospective study over 35 years from a single institution. ( 26586158 )
2016
8
Breast sarcoma: a rare malignancy. ( 24965425 )
2014
9
Spontaneous Perforation as a First Presentation of Ileal Gastrointestinal Stromal Tumour (GIST) with Synchronous Breast Sarcoma. ( 24995213 )
2014
10
Breast sarcoma. ( 23552541 )
2013
11
Breast sarcoma after breast-conserving therapy for breast cancer in a patient with Li-Fraumeni syndrome presenting as focal nonmasslike enhancement on MRI. ( 24261401 )
2013
12
Imaging features of primary breast sarcoma. ( 22451578 )
2012
13
Breast sarcoma in a pregnant patient A case report. ( 23070281 )
2012
14
The CD49d+/high subpopulation from isolated human breast sarcoma spheres possesses tumor-initiating ability. ( 22159714 )
2012
15
Primary breast sarcoma: prevalence, clinical signs, and radiological features. ( 21565891 )
2011
16
Treatment for breast sarcoma: a large, single-centre series. ( 21628089 )
2011
17
Diagnosis and management of primary breast sarcoma. ( 20480227 )
2010
18
Breast sarcoma--a review of diagnosis and management. ( 19114317 )
2009
19
Primary breast sarcoma. ( 18514698 )
2008
20
Treatment and outcomes of patients with primary breast sarcoma. ( 18723152 )
2008
21
Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network. ( 18023492 )
2007
22
Report on a case of breast sarcoma metastatic to the axillary lymph nodes. ( 16724703 )
2006
23
Good outcome after neoadjuvant chemotherapy and extended surgical resection for a large radiation-induced high-grade breast sarcoma. ( 16824232 )
2006
24
A rare case of breast sarcoma brain metastases. ( 15925991 )
2005
25
Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. ( 15187996 )
2004
26
Primary breast sarcoma: case report. ( 15490711 )
2004
27
Breast sarcoma showing myofibroblastic differentiation. ( 12844261 )
2003
28
Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres. ( 12956895 )
2003
29
An unusual case of metastatic post-irradiation breast sarcoma. ( 14965694 )
2002
30
Surgical management of primary breast sarcoma. ( 12206600 )
2002
31
P53 expression is a factor for prognostic assessment in breast sarcoma. ( 12002339 )
2002
32
Radiation-induced breast sarcoma. ( 12383902 )
2002
33
An analysis of 78 breast sarcoma patients without distant metastases at presentation. ( 10661345 )
2000
34
F-18 FDG whole-body positron emission tomography scan in primary breast sarcoma. ( 9735983 )
1998
35
Breast sarcoma. ( 8610270 )
1996
36
Human breast sarcoma and human breast implantation: a time trend analysis based on SEER data (1973-1990). ( 7722610 )
1995
37
Breast sarcoma. A clinicopathologic review of 25 cases. ( 2386920 )
1990
38
Primary breast sarcoma: a review of 33 cases with immunohistochemistry and prognostic factors. ( 2468372 )
1989
39
Breast sarcoma with giant cells and osteoid. ( 3166604 )
1988
40
Breast sarcoma with giant cells and osteoid. A case report and review of the literature. ( 3826481 )
1987
41
Breast sarcoma. ( 3674288 )
1987
42
A breast sarcoma containing rhabdomyosarcomatous and other metaplastic elements. ( 4099010 )
1970
43
Results of 22 cases of breast sarcoma over five years after surgery. ( 4316262 )
1970
44
Recurrent intussusception in an adult, due to intestinal metastases of a breast sarcoma. ( 13811295 )
1959

Variations for Breast Sarcoma

Expression for Breast Sarcoma

Search GEO for disease gene expression data for Breast Sarcoma.

Pathways for Breast Sarcoma

GO Terms for Breast Sarcoma

Sources for Breast Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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