MCID: BRS042
MIFTS: 30

Breast Scirrhous Carcinoma malady

Category: Cancer diseases

Aliases & Classifications for Breast Scirrhous Carcinoma

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Aliases & Descriptions for Breast Scirrhous Carcinoma:

Name: Breast Scirrhous Carcinoma 11 13
Infiltrating Carcinoma of Breast with Fibrotic Stroma 11
 
Scirrhous Carcinoma of Breast 11

Classifications:



External Ids:

Disease Ontology11 DOID:7578
SNOMED-CT61 254839007
NCIt44 C7362

Summaries for Breast Scirrhous Carcinoma

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MalaCards based summary: Breast Scirrhous Carcinoma, also known as infiltrating carcinoma of breast with fibrotic stroma, is related to cutaneous mucoepidermoid carcinoma and vaginal adenosarcoma. An important gene associated with Breast Scirrhous Carcinoma is PGR (Progesterone Receptor), and among its related pathways are Central carbon metabolism in cancer and Adherens junction. Affiliated tissues include breast and lymph node, and related mouse phenotypes are embryo and integument.

Related Diseases for Breast Scirrhous Carcinoma

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Diseases related to Breast Scirrhous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous mucoepidermoid carcinoma10.3ERBB2, PGR
2vaginal adenosarcoma10.3ERBB2, PGR
3focal chorioretinitis10.3ERBB2, PGR
4retinitis10.3ERBB2, PGR
5kidney pelvis sarcomatoid transitional cell carcinoma10.3EGFR, ERBB2
6prostate adenoid cystic carcinoma10.2EGFR, PGR
7mucinous cystadenocarcinoma10.2EGFR, ERBB2
8gastric squamous cell carcinoma10.2EGFR, ERBB2
9breast metaplastic carcinoma10.2MUC1, PGR
10endometriosis of pelvic peritoneum10.2MUC1, PGR
11congenital structural myopathy10.2MUC1, PGR
12adenosquamous carcinoma10.2EGFR, ERBB2
13scrotal carcinoma10.2EGFR, ERBB2
14serous surface papilloma10.2MUC1, PGR
15ampulla of vater adenocarcinoma10.2EGFR, ERBB2
16benign mesenchymoma10.2MUC1, PGR
17parachordoma10.2MUC1, PGR
18early congenital syphilis10.2EGFR, ERBB2
19postcricoid region cancer10.2MUC1, PGR
20poliomyelitis10.2MUC1, PGR
21distal monosomy 7q3610.2EGFR, MUC1
22pemphigus vulgaris, familial10.2ERBB2, MUC1
23kidney benign neoplasm10.2ERBB2, PGR
24postpoliomyelitis syndrome10.2EGFR, ERBB2
25breast pericanalicular fibroadenoma10.1MUC1, PGR
26luminal breast carcinoma10.1EGFR, MUC1
27tonsil cancer10.1EGFR, ERBB2
28chronic interstitial cystitis10.1MUC1, PGR
29papillary carcinoma10.1MUC1, PGR
30bronchiolo-alveolar adenocarcinoma10.1ERBB2, MUC1
31lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy10.1MUC1, PGR
32submucosal invasive colon adenocarcinoma10.1EGFR, MUC1
33myoepithelial carcinoma10.1EGFR, MUC1
34renal tubular acidosis, distal, autosomal recessive10.1EGFR, MUC1
35vulvar angiokeratoma10.1ESR1, PGR
36central nervous system organ benign neoplasm10.1ESR1, PGR
37fallopian tube benign neoplasm10.1ESR1, PGR
38appendix leiomyoma10.1ESR1, PGR
39mixed cell adenoma10.0ESR1, PGR
40deafness, autosomal dominant 8/1210.0ESR1, PGR
41perinatal intestinal perforation10.0ESR1, PGR
42adult mesoblastic nephroma10.0EGFR, ERBB2
43asthma susceptibility 510.0ESR1, PGR
44gallbladder squamous cell carcinoma10.0ESR1, PGR
45amyloid tumor10.0ESR1, PGR
46malignant mediastinal neurogenic neoplasm10.0ESR1, PGR
47diplegia of upper limb10.0EGFR, ERBB2
48retroperitoneum carcinoma10.0ESR1, PGR
49cervix endometrial stromal tumor10.0ERBB2, MUC1
50uterine body mixed cancer10.0ESR1, PGR

Graphical network of the top 20 diseases related to Breast Scirrhous Carcinoma:



Diseases related to breast scirrhous carcinoma

Symptoms for Breast Scirrhous Carcinoma

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Drugs & Therapeutics for Breast Scirrhous Carcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Breast Scirrhous Carcinoma

Genetic Tests for Breast Scirrhous Carcinoma

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Anatomical Context for Breast Scirrhous Carcinoma

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MalaCards organs/tissues related to Breast Scirrhous Carcinoma:

35
Breast, Lymph node

Animal Models for Breast Scirrhous Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Breast Scirrhous Carcinoma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.9EGFR, ERBB2, ESR1, PGR
2MP:00107718.9EGFR, ERBB2, ESR1, PGR
3MP:00053718.9EGFR, ERBB2, ESR1, PGR
4MP:00053698.8EGFR, ERBB2, ESR1, PGR
5MP:00020068.2EGFR, ERBB2, ESR1, PGR

Publications for Breast Scirrhous Carcinoma

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Articles related to Breast Scirrhous Carcinoma:

idTitleAuthorsYear
1
Establishment and characterization of HER2-positive cell line derived from pleural effusion of human breast scirrhous carcinoma. (19067762)
2008
2
Establishment and characterization of a cell line (NABCA) derived from metastatic lymph nodes of breast scirrhous carcinoma. (17257375)
2006

Variations for Breast Scirrhous Carcinoma

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Expression for genes affiliated with Breast Scirrhous Carcinoma

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Search GEO for disease gene expression data for Breast Scirrhous Carcinoma.

Pathways for genes affiliated with Breast Scirrhous Carcinoma

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GO Terms for genes affiliated with Breast Scirrhous Carcinoma

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Cellular components related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:00163248.8EGFR, ERBB2, MUC1

Biological processes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of phosphatidylinositol 3-kinase signalingGO:001406610.0EGFR, ERBB2
2cellular response to epidermal growth factor stimulusGO:00713649.9EGFR, ERBB2
3ERBB2 signaling pathwayGO:00381289.9EGFR, ERBB2
4cellular response to growth factor stimulusGO:00713639.8EGFR, ERBB2
5positive regulation of MAP kinase activityGO:00434069.8EGFR, ERBB2
6regulation of cell motilityGO:20001459.7EGFR, ERBB2
7cellular response to estradiol stimulusGO:00713929.6EGFR, ESR1
8positive regulation of fibroblast proliferationGO:00481469.6EGFR, ESR1
9positive regulation of cell growthGO:00303079.3EGFR, ERBB2
10positive regulation of epithelial cell proliferationGO:00506799.0EGFR, ERBB2, ESR1
11signal transductionGO:00071658.2EGFR, ERBB2, ESR1, PGR

Molecular functions related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.9EGFR, ERBB2
2steroid hormone receptor activityGO:00037079.8ESR1, PGR
3transmembrane receptor protein tyrosine kinase activityGO:00047149.8EGFR, ERBB2
4nitric-oxide synthase regulator activityGO:00302359.6EGFR, ESR1
5steroid bindingGO:00054969.6ESR1, PGR
6protein phosphatase bindingGO:00199039.5EGFR, ERBB2
7ATPase bindingGO:00511179.3ESR1, PGR
8enzyme bindingGO:00198998.7EGFR, ESR1, PGR
9RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009788.3ESR1, MUC1, PGR

Sources for Breast Scirrhous Carcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet