MCID: BRS042
MIFTS: 30

Breast Scirrhous Carcinoma malady

Categories: Cancer diseases

Aliases & Classifications for Breast Scirrhous Carcinoma

Aliases & Descriptions for Breast Scirrhous Carcinoma:

Name: Breast Scirrhous Carcinoma 12 14
Infiltrating Carcinoma of Breast with Fibrotic Stroma 12
Scirrhous Carcinoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7578
NCIt 47 C7362
SNOMED-CT 64 254839007
UMLS 69 C0346151

Summaries for Breast Scirrhous Carcinoma

MalaCards based summary : Breast Scirrhous Carcinoma, also known as infiltrating carcinoma of breast with fibrotic stroma, is related to mouth disease and mucoepidermoid thyroid carcinoma. An important gene associated with Breast Scirrhous Carcinoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Glioma and Development ERBB-family signaling. Affiliated tissues include breast and lymph node, and related phenotypes are Decreased viability and embryo

Related Diseases for Breast Scirrhous Carcinoma

Diseases related to Breast Scirrhous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
id Related Disease Score Top Affiliating Genes
1 mouth disease 10.2 ERBB2 PGR
2 mucoepidermoid thyroid carcinoma 10.2 ERBB2 PGR
3 intestinal neuroendocrine benign tumor 10.2 ERBB2 PGR
4 infiltrating angiolipoma 10.2 ERBB2 PGR
5 pineal region mature teratoma 10.2 EGFR ERBB2
6 ovarian embryonal carcinoma 10.2 EGFR PGR
7 lacrimal gland mucoepidermoid carcinoma 10.1 MUC1 PGR
8 ovarian cystadenocarcinoma 10.1 EGFR ERBB2
9 exotropia 10.1 MUC1 PGR
10 marfanoid hypermobility syndrome 10.1 MUC1 PGR
11 endometrial stromal sarcoma 10.1 MUC1 PGR
12 porokeratosis 10.1 MUC1 PGR
13 papilloma 10.1 MUC1 PGR
14 nipple neoplasm 10.1 MUC1 PGR
15 sebaceous adenoma 10.1 MUC1 PGR
16 prostate signet ring cell adenocarcinoma 10.1 EGFR ERBB2
17 mesenchymoma 10.1 MUC1 PGR
18 immunodeficiency due to a classical component pathway complement deficiency 10.1 EGFR MUC1
19 bone marrow cancer 10.1 MUC1 PGR
20 spongiotic dermatitis 10.1 EGFR ERBB2
21 vascular hemostatic disease 10.1 EGFR ERBB2
22 perinatal necrotizing enterocolitis 10.1 MUC1 PGR
23 lethal congenital contracture syndrome 10.1 EGFR MUC1
24 precursor t-lymphoblastic lymphoma/leukemia 10.1 EGFR MUC1
25 angiolipomatosis, familial 10.1 ERBB2 MUC1
26 nasal cavity adenocarcinoma 10.1 ERBB2 MUC1
27 struma ovarii 10.1 MUC1 PGR
28 multinodular goiter 10.1 EGFR ERBB2
29 bartholin's gland benign neoplasm 10.1 ESR1 PGR
30 scirrhous adenocarcinoma 10.1 MUC1 PGR
31 cardiovascular organ benign neoplasm 10.1 ESR1 PGR
32 appendix leiomyoma 10.1 ESR1 PGR
33 bronchus adenoma 10.1 ESR1 PGR
34 ovarian benign neoplasm 10.1 ESR1 PGR
35 plexiform neurofibroma 10.1 ESR1 PGR
36 paranasal sinus disease 10.1 ESR1 PGR
37 deafness, autosomal recessive 21 10.1 ESR1 PGR
38 allergic contact dermatitis 10.1 EGFR MUC1
39 atypical lipomatous tumor 10.1 ESR1 PGR
40 pediatric intraocular retinoblastoma 10.1 ESR1 PGR
41 congenital disorder of glycosylation, type ic 10.1 ESR1 PGR
42 intestinal perforation 10.1 ESR1 PGR
43 perlman syndrome 10.1 ESR1 PGR
44 anal neuroendocrine tumor 10.0 ESR1 PGR
45 osteogenesis imperfecta 10.0 ESR1 PGR
46 vulva basal cell carcinoma 10.0 ESR1 PGR
47 villoglandular endometrial endometrioid adenocarcinoma 10.0 ESR1 PGR
48 vaginal adenosarcoma 10.0 ESR1 PGR
49 intraneural perineurioma 10.0 ESR1 PGR
50 kidney benign neoplasm 10.0 MUC1 PGR

Graphical network of the top 20 diseases related to Breast Scirrhous Carcinoma:



Diseases related to Breast Scirrhous Carcinoma

Symptoms & Phenotypes for Breast Scirrhous Carcinoma

GenomeRNAi Phenotypes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.56 EGFR
2 Decreased viability GR00221-A-1 9.56 EGFR ESR1
3 Decreased viability GR00221-A-2 9.56 ESR1
4 Decreased viability GR00221-A-3 9.56 ERBB2
5 Decreased viability GR00221-A-4 9.56 EGFR ERBB2 ESR1
6 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.33 EGFR ERBB2 MUC1
7 Decreased viability with paclitaxel GR00179-A-1 8.8 ERBB2 EGFR
8 Decreased viability with paclitaxel GR00179-A-3 8.8 EGFR

MGI Mouse Phenotypes related to Breast Scirrhous Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.56 EGFR ERBB2 ESR1 PGR
2 limbs/digits/tail MP:0005371 9.46 EGFR ERBB2 ESR1 PGR
3 muscle MP:0005369 9.26 EGFR ERBB2 ESR1 PGR
4 neoplasm MP:0002006 8.92 EGFR ERBB2 ESR1 PGR

Drugs & Therapeutics for Breast Scirrhous Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Scirrhous Carcinoma

Genetic Tests for Breast Scirrhous Carcinoma

Anatomical Context for Breast Scirrhous Carcinoma

MalaCards organs/tissues related to Breast Scirrhous Carcinoma:

39
Breast, Lymph Node

Publications for Breast Scirrhous Carcinoma

Articles related to Breast Scirrhous Carcinoma:

id Title Authors Year
1
Establishment and characterization of HER2-positive cell line derived from pleural effusion of human breast scirrhous carcinoma. ( 19067762 )
2008
2
Establishment and characterization of a cell line (NABCA) derived from metastatic lymph nodes of breast scirrhous carcinoma. ( 17257375 )
2006

Variations for Breast Scirrhous Carcinoma

Expression for Breast Scirrhous Carcinoma

Search GEO for disease gene expression data for Breast Scirrhous Carcinoma.

Pathways for Breast Scirrhous Carcinoma

Pathways related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.32 EGFR ERBB2 ESR1 PGR
2
Show member pathways
12.11 EGFR ERBB2 MUC1
3
Show member pathways
11.82 EGFR ERBB2 ESR1
4 11.74 EGFR ERBB2 ESR1
5 11.43 EGFR ERBB2
6 11.42 EGFR ERBB2
7
Show member pathways
11.39 EGFR ESR1
8 11.37 EGFR ERBB2
9 11.34 EGFR ESR1
10 11.32 EGFR ERBB2
11 11.24 EGFR ERBB2
12 11.16 EGFR ESR1
13 11.11 EGFR ERBB2
14
Show member pathways
11.1 EGFR ERBB2 ESR1
15
Show member pathways
10.96 EGFR ERBB2 ESR1 PGR
16 10.9 EGFR ERBB2
17 10.85 EGFR ERBB2

GO Terms for Breast Scirrhous Carcinoma

Cellular components related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 EGFR ERBB2 MUC1

Biological processes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 regulation of transcription from RNA polymerase II promoter GO:0006357 9.69 EGFR ERBB2 ESR1
2 positive regulation of cell growth GO:0030307 9.54 EGFR ERBB2
3 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.52 EGFR ERBB2
4 positive regulation of epithelial cell proliferation GO:0050679 9.49 EGFR ERBB2
5 steroid hormone mediated signaling pathway GO:0043401 9.48 ESR1 PGR
6 positive regulation of MAP kinase activity GO:0043406 9.46 EGFR ERBB2
7 cellular response to growth factor stimulus GO:0071363 9.43 EGFR ERBB2
8 positive regulation of fibroblast proliferation GO:0048146 9.4 EGFR ESR1
9 cellular response to epidermal growth factor stimulus GO:0071364 9.37 EGFR ERBB2
10 cellular response to estradiol stimulus GO:0071392 9.32 EGFR ESR1
11 ERBB2 signaling pathway GO:0038128 9.26 EGFR ERBB2
12 regulation of cell motility GO:2000145 9.16 EGFR ERBB2
13 regulation of ERK1 and ERK2 cascade GO:0070372 8.96 EGFR ERBB2
14 negative regulation of ERBB signaling pathway GO:1901185 8.62 EGFR ERBB2

Molecular functions related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.54 EGFR ESR1 PGR
2 ATPase binding GO:0051117 9.49 ESR1 PGR
3 protein phosphatase binding GO:0019903 9.48 EGFR ERBB2
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.46 EGFR ERBB2
5 steroid hormone receptor activity GO:0003707 9.43 ESR1 PGR
6 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.43 ESR1 MUC1 PGR
7 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.4 EGFR ERBB2
8 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.32 ESR1 PGR
9 steroid binding GO:0005496 9.16 ESR1 PGR
10 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.96 EGFR ERBB2
11 nitric-oxide synthase regulator activity GO:0030235 8.62 EGFR ESR1

Sources for Breast Scirrhous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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