MCID: BRS042
MIFTS: 30

Breast Scirrhous Carcinoma malady

Category: Cancer diseases

Aliases & Classifications for Breast Scirrhous Carcinoma

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Aliases & Descriptions for Breast Scirrhous Carcinoma:

Name: Breast Scirrhous Carcinoma 11 13
Infiltrating Carcinoma of Breast with Fibrotic Stroma 11
 
Scirrhous Carcinoma of Breast 11

Classifications:



External Ids:

Disease Ontology11 DOID:7578
SNOMED-CT62 254839007
NCIt45 C7362

Summaries for Breast Scirrhous Carcinoma

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MalaCards based summary: Breast Scirrhous Carcinoma, also known as infiltrating carcinoma of breast with fibrotic stroma, is related to mouth disease and mucoepidermoid thyroid carcinoma. An important gene associated with Breast Scirrhous Carcinoma is PGR (Progesterone Receptor), and among its related pathways are Central carbon metabolism in cancer and Agrin Interactions at Neuromuscular Junction. Affiliated tissues include breast and lymph node, and related mouse phenotypes are Decreased viability with paclitaxel and Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance.

Related Diseases for Breast Scirrhous Carcinoma

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Diseases related to Breast Scirrhous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1mouth disease10.2ERBB2, PGR
2mucoepidermoid thyroid carcinoma10.2ERBB2, PGR
3intestinal neuroendocrine benign tumor10.2ERBB2, PGR
4infiltrating angiolipoma10.2ERBB2, PGR
5pineal region mature teratoma10.2EGFR, ERBB2
6ovarian embryonal carcinoma10.2EGFR, PGR
7lacrimal gland mucoepidermoid carcinoma10.1MUC1, PGR
8ovarian cystadenocarcinoma10.1EGFR, ERBB2
9exotropia10.1MUC1, PGR
10marfanoid hypermobility syndrome10.1MUC1, PGR
11endometrial stromal sarcoma10.1MUC1, PGR
12porokeratosis10.1MUC1, PGR
13papilloma10.1MUC1, PGR
14nipple neoplasm10.1MUC1, PGR
15sebaceous adenoma10.1MUC1, PGR
16prostate signet ring cell adenocarcinoma10.1EGFR, ERBB2
17mesenchymoma10.1MUC1, PGR
18immunodeficiency due to a classical component pathway complement deficiency10.1EGFR, MUC1
19bone marrow cancer10.1MUC1, PGR
20spongiotic dermatitis10.1EGFR, ERBB2
21vascular hemostatic disease10.1EGFR, ERBB2
22perinatal necrotizing enterocolitis10.1MUC1, PGR
23lethal congenital contracture syndrome10.1EGFR, MUC1
24precursor t-lymphoblastic lymphoma/leukemia10.1EGFR, MUC1
25angiolipomatosis, familial10.1ERBB2, MUC1
26nasal cavity adenocarcinoma10.1ERBB2, MUC1
27struma ovarii10.1MUC1, PGR
28multinodular goiter10.1EGFR, ERBB2
29bartholin's gland benign neoplasm10.1ESR1, PGR
30scirrhous adenocarcinoma10.1MUC1, PGR
31cardiovascular organ benign neoplasm10.1ESR1, PGR
32appendix leiomyoma10.1ESR1, PGR
33bronchus adenoma10.1ESR1, PGR
34ovarian benign neoplasm10.1ESR1, PGR
35plexiform neurofibroma10.1ESR1, PGR
36paranasal sinus disease10.1ESR1, PGR
37deafness, autosomal recessive 2110.1ESR1, PGR
38allergic contact dermatitis10.1EGFR, MUC1
39atypical lipomatous tumor10.1ESR1, PGR
40pediatric intraocular retinoblastoma10.1ESR1, PGR
41congenital disorder of glycosylation, type ic10.1ESR1, PGR
42intestinal perforation10.1ESR1, PGR
43perlman syndrome10.1ESR1, PGR
44anal neuroendocrine tumor10.0ESR1, PGR
45osteogenesis imperfecta10.0ESR1, PGR
46vulva basal cell carcinoma10.0ESR1, PGR
47villoglandular endometrial endometrioid adenocarcinoma10.0ESR1, PGR
48vaginal adenosarcoma10.0ESR1, PGR
49intraneural perineurioma10.0ESR1, PGR
50kidney benign neoplasm10.0MUC1, PGR

Graphical network of the top 20 diseases related to Breast Scirrhous Carcinoma:



Diseases related to breast scirrhous carcinoma

Symptoms & Phenotypes for Breast Scirrhous Carcinoma

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GenomeRNAi Phenotypes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00293-A10.2EGFR, ERBB2
2GR00210-A9.6EGFR, ERBB2, MUC1
3GR00381-A-19.4EGFR, ERBB2, ESR1

MGI Mouse Phenotypes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.9EGFR, ERBB2, ESR1, PGR
2MP:00053718.9EGFR, ERBB2, ESR1, PGR
3MP:00053698.8EGFR, ERBB2, ESR1, PGR
4MP:00020068.2EGFR, ERBB2, ESR1, PGR

Drugs & Therapeutics for Breast Scirrhous Carcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Breast Scirrhous Carcinoma

Genetic Tests for Breast Scirrhous Carcinoma

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Anatomical Context for Breast Scirrhous Carcinoma

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MalaCards organs/tissues related to Breast Scirrhous Carcinoma:

36
Breast, Lymph node

Publications for Breast Scirrhous Carcinoma

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Articles related to Breast Scirrhous Carcinoma:

idTitleAuthorsYear
1
Establishment and characterization of HER2-positive cell line derived from pleural effusion of human breast scirrhous carcinoma. (19067762)
2008
2
Establishment and characterization of a cell line (NABCA) derived from metastatic lymph nodes of breast scirrhous carcinoma. (17257375)
2006

Variations for Breast Scirrhous Carcinoma

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Expression for genes affiliated with Breast Scirrhous Carcinoma

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Search GEO for disease gene expression data for Breast Scirrhous Carcinoma.

Pathways for genes affiliated with Breast Scirrhous Carcinoma

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Pathways related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathwaysScoreTop Affiliating Genes
19.4EGFR, ERBB2
29.4EGFR, ERBB2
39.4EGFR, ERBB2
49.4EGFR, ERBB2
5
Show member pathways
9.4EGFR, ERBB2
69.4EGFR, ERBB2
79.4EGFR, ERBB2
89.4EGFR, ERBB2
99.1EGFR, ESR1
109.1EGFR, ESR1
11
Show member pathways
9.1EGFR, ESR1
12
Show member pathways
8.8EGFR, ERBB2, MUC1
13
Show member pathways
8.6EGFR, ERBB2, ESR1
14
Show member pathways
8.6EGFR, ERBB2, ESR1
158.6EGFR, ERBB2, ESR1
16
Show member pathways
8.2EGFR, ERBB2, ESR1, PGR
17
Show member pathways
8.2EGFR, ERBB2, ESR1, PGR

GO Terms for genes affiliated with Breast Scirrhous Carcinoma

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Cellular components related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:00163248.8EGFR, ERBB2, MUC1

Biological processes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cellular response to epidermal growth factor stimulusGO:007136410.1EGFR, ERBB2
2cellular response to growth factor stimulusGO:007136310.1EGFR, ERBB2
3ERBB2 signaling pathwayGO:003812810.1EGFR, ERBB2
4negative regulation of ERBB signaling pathwayGO:190118510.1EGFR, ERBB2
5positive regulation of cell growthGO:003030710.1EGFR, ERBB2
6positive regulation of epithelial cell proliferationGO:005067910.1EGFR, ERBB2
7positive regulation of MAP kinase activityGO:004340610.1EGFR, ERBB2
8regulation of cell motilityGO:200014510.1EGFR, ERBB2
9regulation of ERK1 and ERK2 cascadeGO:007037210.1EGFR, ERBB2
10regulation of phosphatidylinositol 3-kinase signalingGO:001406610.1EGFR, ERBB2
11cellular response to estradiol stimulusGO:00713929.8EGFR, ESR1
12positive regulation of fibroblast proliferationGO:00481469.8EGFR, ESR1
13steroid hormone mediated signaling pathwayGO:00434019.2ESR1, PGR
14regulation of transcription from RNA polymerase II promoterGO:00063579.1EGFR, ERBB2, ESR1

Molecular functions related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:004693410.1EGFR, ERBB2
2protein phosphatase bindingGO:001990310.1EGFR, ERBB2
3signal transducer, downstream of receptor, with protein tyrosine kinase activityGO:000471610.0EGFR, ERBB2
4ATPase bindingGO:00511179.9ESR1, PGR
5nitric-oxide synthase regulator activityGO:00302359.8EGFR, ESR1
6RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:00048799.8ESR1, PGR
7steroid bindingGO:00054969.7ESR1, PGR
8steroid hormone receptor activityGO:00037079.7ESR1, PGR
9transmembrane receptor protein tyrosine kinase activityGO:00047149.4EGFR, ERBB2
10enzyme bindingGO:00198999.3EGFR, ESR1, PGR
11RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009789.2ESR1, MUC1, PGR

Sources for Breast Scirrhous Carcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet