MCID: BRS042
MIFTS: 32

Breast Scirrhous Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Scirrhous Carcinoma

MalaCards integrated aliases for Breast Scirrhous Carcinoma:

Name: Breast Scirrhous Carcinoma 12 14
Infiltrating Carcinoma of Breast with Fibrotic Stroma 12
Scirrhous Carcinoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7578
NCIt 46 C7362
SNOMED-CT 64 254839007
UMLS 69 C0346151

Summaries for Breast Scirrhous Carcinoma

MalaCards based summary : Breast Scirrhous Carcinoma, also known as infiltrating carcinoma of breast with fibrotic stroma, is related to scirrhous adenocarcinoma and breast apocrine carcinoma. An important gene associated with Breast Scirrhous Carcinoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Pathways in cancer and Relaxin signaling pathway. Affiliated tissues include breast and lymph node, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Breast Scirrhous Carcinoma

Diseases related to Breast Scirrhous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 scirrhous adenocarcinoma 10.2 ERBB2 PGR
2 breast apocrine carcinoma 10.2 ERBB2 PGR
3 uterine body mixed cancer 10.2 ERBB2 PGR
4 breast intraductal proliferative lesion 10.2 EGFR ERBB2
5 tumor suppressor gene on chromosome 11 10.2 EGFR ERBB2
6 breast mucoepidermoid carcinoma 10.2 MUC1 PGR
7 endosalpingiosis 10.2 MUC1 PGR
8 malignant mixed mullerian tumor 10.1 MUC1 PGR
9 clear cell meningioma 10.1 MUC1 PGR
10 chordoid glioma 10.1 MUC1 PGR
11 acneiform dermatitis 10.1 EGFR ERBB2
12 adenosquamous cell lung carcinoma 10.1 EGFR ERBB2
13 perivascular epithelioid cell tumor 10.1 MUC1 PGR
14 gallbladder adenocarcinoma 10.1 EGFR ERBB2
15 sertoli-leydig cell tumor 10.1 MUC1 PGR
16 malignant peritoneal mesothelioma 10.1 EGFR MUC1
17 dermoid cyst 10.1 MUC1 PGR
18 chickenpox 10.1 MUC1 PGR
19 exanthem 10.1 EGFR ERBB2
20 hepatoid adenocarcinoma 10.1 EGFR MUC1
21 cystadenoma 10.1 MUC1 PGR
22 paget disease, extramammary 10.1 ERBB2 MUC1
23 spindle cell carcinoma 10.1 MUC1 PGR
24 salivary gland cancer 10.0 EGFR ERBB2
25 cystadenocarcinoma 10.0 MUC1 PGR
26 mucinous adenocarcinoma 10.0 EGFR MUC1
27 pneumothorax 10.0 MUC1 PGR
28 ependymoma 10.0 EGFR MUC1
29 vulvar syringoma 10.0 ESR1 PGR
30 vestibular gland benign neoplasm 10.0 ESR1 PGR
31 lung leiomyoma 10.0 ESR1 PGR
32 bartholin's gland adenoma 10.0 ESR1 PGR
33 vulvar benign neoplasm 10.0 ESR1 PGR
34 trigonitis 10.0 ESR1 PGR
35 chordoma 10.0 EGFR MUC1
36 vulvar leiomyoma 10.0 ESR1 PGR
37 predominantly cortical thymoma 10.0 ESR1 PGR
38 progesterone resistance 10.0 ESR1 PGR
39 cribriform carcinoma 10.0 ESR1 PGR
40 bartholin's gland benign neoplasm 10.0 ESR1 PGR
41 endometrial squamous cell carcinoma 10.0 ESR1 PGR
42 gastric signet ring cell adenocarcinoma 10.0 ESR1 PGR
43 adenosquamous carcinoma 10.0 EGFR MUC1
44 adenoid basal cell carcinoma 10.0 ESR1 PGR
45 deep angioma 10.0 ESR1 PGR
46 gender identity disorder 10.0 ESR1 PGR
47 cervical carcinosarcoma 10.0 ESR1 PGR
48 synchronous bilateral breast carcinoma 10.0 ESR1 PGR
49 oral cavity cancer 10.0 EGFR ERBB2
50 intramuscular hemangioma 10.0 ESR1 PGR

Graphical network of the top 20 diseases related to Breast Scirrhous Carcinoma:



Diseases related to Breast Scirrhous Carcinoma

Symptoms & Phenotypes for Breast Scirrhous Carcinoma

GenomeRNAi Phenotypes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.56 EGFR
2 Decreased viability GR00221-A-1 9.56 EGFR ESR1
3 Decreased viability GR00221-A-2 9.56 ESR1
4 Decreased viability GR00221-A-3 9.56 ERBB2
5 Decreased viability GR00221-A-4 9.56 EGFR ERBB2 ESR1
6 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.33 EGFR ERBB2 MUC1
7 Decreased viability with paclitaxel GR00179-A-1 8.8 EGFR ERBB2
8 Decreased viability with paclitaxel GR00179-A-3 8.8 EGFR

MGI Mouse Phenotypes related to Breast Scirrhous Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.46 EGFR ERBB2 ESR1 PGR
2 muscle MP:0005369 9.26 EGFR ERBB2 ESR1 PGR
3 neoplasm MP:0002006 8.92 EGFR ERBB2 ESR1 PGR

Drugs & Therapeutics for Breast Scirrhous Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Scirrhous Carcinoma

Genetic Tests for Breast Scirrhous Carcinoma

Anatomical Context for Breast Scirrhous Carcinoma

MalaCards organs/tissues related to Breast Scirrhous Carcinoma:

38
Breast, Lymph Node

Publications for Breast Scirrhous Carcinoma

Articles related to Breast Scirrhous Carcinoma:

# Title Authors Year
1
Establishment and characterization of HER2-positive cell line derived from pleural effusion of human breast scirrhous carcinoma. ( 19067762 )
2008
2
Establishment and characterization of a cell line (NABCA) derived from metastatic lymph nodes of breast scirrhous carcinoma. ( 17257375 )
2006

Variations for Breast Scirrhous Carcinoma

Expression for Breast Scirrhous Carcinoma

Search GEO for disease gene expression data for Breast Scirrhous Carcinoma.

Pathways for Breast Scirrhous Carcinoma

Pathways related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1 12.48 EGFR ERBB2 ESR1
2
Show member pathways
12.15 EGFR ERBB2 ESR1
3
Show member pathways
12.12 EGFR ERBB2 ESR1 PGR
4
Show member pathways
12.03 EGFR ERBB2 MUC1
5
Show member pathways
11.82 EGFR ERBB2 ESR1
6 11.74 EGFR ERBB2 ESR1
7 11.44 EGFR ERBB2
8 11.42 EGFR ERBB2
9
Show member pathways
11.4 EGFR ESR1
10 11.38 EGFR ERBB2
11 11.36 EGFR ESR1
12 11.34 EGFR ERBB2
13 11.26 EGFR ERBB2
14 11.18 EGFR ESR1
15 11.13 EGFR ERBB2
16
Show member pathways
11.1 EGFR ERBB2 ESR1
17
Show member pathways
10.96 EGFR ERBB2 ESR1 PGR
18 10.92 EGFR ERBB2
19 10.88 EGFR ERBB2

GO Terms for Breast Scirrhous Carcinoma

Cellular components related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 EGFR ERBB2 MUC1

Biological processes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.71 EGFR ERBB2 ESR1
2 positive regulation of cell growth GO:0030307 9.52 EGFR ERBB2
3 positive regulation of epithelial cell proliferation GO:0050679 9.51 EGFR ERBB2
4 positive regulation of MAP kinase activity GO:0043406 9.49 EGFR ERBB2
5 steroid hormone mediated signaling pathway GO:0043401 9.48 ESR1 PGR
6 cellular response to growth factor stimulus GO:0071363 9.46 EGFR ERBB2
7 signal transduction by protein phosphorylation GO:0023014 9.43 EGFR ERBB2
8 positive regulation of fibroblast proliferation GO:0048146 9.4 EGFR ESR1
9 cellular response to epidermal growth factor stimulus GO:0071364 9.37 EGFR ERBB2
10 ERBB2 signaling pathway GO:0038128 9.32 EGFR ERBB2
11 cellular response to estradiol stimulus GO:0071392 9.26 EGFR ESR1
12 regulation of cell motility GO:2000145 9.16 EGFR ERBB2
13 regulation of ERK1 and ERK2 cascade GO:0070372 8.96 EGFR ERBB2
14 negative regulation of ERBB signaling pathway GO:1901185 8.62 EGFR ERBB2

Molecular functions related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.58 ESR1 MUC1 PGR
2 identical protein binding GO:0042802 9.56 EGFR ERBB2 ESR1 PGR
3 enzyme binding GO:0019899 9.54 EGFR ESR1 PGR
4 ATPase binding GO:0051117 9.51 ESR1 PGR
5 protein phosphatase binding GO:0019903 9.49 EGFR ERBB2
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.48 EGFR ERBB2
7 steroid hormone receptor activity GO:0003707 9.46 ESR1 PGR
8 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.43 EGFR ERBB2
9 nuclear receptor activity GO:0004879 9.32 ESR1 PGR
10 steroid binding GO:0005496 9.16 ESR1 PGR
11 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.96 EGFR ERBB2
12 nitric-oxide synthase regulator activity GO:0030235 8.62 EGFR ESR1

Sources for Breast Scirrhous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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