MCID: BRS042
MIFTS: 29

Breast Scirrhous Carcinoma malady

Cancer diseases category

Aliases & Classifications for Breast Scirrhous Carcinoma

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Aliases & Descriptions for Breast Scirrhous Carcinoma:

Name: Breast Scirrhous Carcinoma 10
Scirrhous Carcinoma of Breast 10 65
 
Infiltrating Carcinoma of Breast with Fibrotic Stroma 10


Classifications:



External Ids:

Disease Ontology10 DOID:7578
SNOMED-CT59 254839007
NCIt42 C7362

Summaries for Breast Scirrhous Carcinoma

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MalaCards based summary: Breast Scirrhous Carcinoma, also known as scirrhous carcinoma of breast, is related to breast metaplastic carcinoma and breast mucinous carcinoma. An important gene associated with Breast Scirrhous Carcinoma is PGR (Progesterone Receptor), and among its related pathways are Agrin Interactions at Neuromuscular Junction and Akt Signaling Pathway. Affiliated tissues include breast and lymph node, and related mouse phenotypes are skeleton and limbs/digits/tail.

Related Diseases for Breast Scirrhous Carcinoma

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Diseases related to Breast Scirrhous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1breast metaplastic carcinoma10.2EGFR, ERBB2
2breast mucinous carcinoma10.2ERBB2, PGR
3uterine corpus cancer10.2ERBB2, PGR
4bilirubin metabolic disorder10.2EGFR, ERBB2
5breast leiomyosarcoma10.2ERBB2, PGR
6cystic basal cell carcinoma10.2EGFR, ERBB2
7bronchial disease10.1EGFR, ERBB2
8breast myoepitheliosis10.1ERBB2, PGR
9scheuermann's disease10.1EGFR, ERBB2
10kidney cortex necrosis10.1ERBB2, PGR
11vaginal adenosarcoma10.1ERBB2, PGR
12nontoxic goiter10.1EGFR, ERBB2
13fallopian tube carcinosarcoma10.1ERBB2, PGR
14gallbladder cancer10.1EGFR, ERBB2
15excessive tearing10.1EGFR, ERBB2
16pagod syndrome10.1ERBB2, MUC1
17iris mixed cell melanoma10.1EGFR, PGR
18splenic artery aneurysm10.1MUC1, PGR
19malignant teratocarcinosarcoma10.1MUC1, PGR
20endometriosis of intestine10.1MUC1, PGR
21salivary gland disease10.1EGFR, ERBB2
22rift valley fever10.1MUC1, PGR
23mixed germ cell-sex cord neoplasm10.1MUC1, PGR
24pituitary hypoplasia10.1MUC1, PGR
25scoliosis10.1MUC1, PGR
26orbit rhabdomyosarcoma10.1EGFR, ERBB2
27adult liposarcoma10.0MUC1, PGR
28epidermal nevus vitamin d resistant rickets10.0EGFR, MUC1
29thymoma10.0EGFR, MUC1
30trabecular follicular adenocarcinoma10.0MUC1, PGR
31heart leiomyosarcoma10.0ERBB2, ESR1
32pineal region yolk sac tumor10.0MUC1, PGR
33ampullary signet ring cell adenocarcinoma10.0EGFR, MUC1
34ciliary body disease10.0ERBB2, ESR1
35poliomyelitis10.0MUC1, PGR
36cystadenofibroma10.0MUC1, PGR
37ametropic amblyopia10.0ERBB2, MUC1
38pancreatic ductal adenocarcinoma10.0EGFR, MUC1
39vulvar melanoma10.0ESR1, PGR
40childhood teratocarcinoma of the testis10.0ESR1, PGR
41rectum rhabdomyosarcoma10.0ESR1, PGR
42vestibulocochlear nerve disease10.0ESR1, PGR
43malignant pineal area germ cell neoplasm10.0EGFR, MUC1
44vulvar disease10.0ESR1, PGR
45vulvar sarcoma10.0ESR1, PGR
46tuberous sclerosis10.0ESR1, PGR
47progesterone resistance10.0ESR1, PGR
48metachronous kidney wilms' tumor10.0ESR1, PGR
49sarcomatoid basal cell carcinoma10.0ESR1, PGR
50bartonellosis10.0ESR1, PGR

Graphical network of the top 20 diseases related to Breast Scirrhous Carcinoma:



Diseases related to breast scirrhous carcinoma

Symptoms for Breast Scirrhous Carcinoma

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Drugs & Therapeutics for Breast Scirrhous Carcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Breast Scirrhous Carcinoma

Genetic Tests for Breast Scirrhous Carcinoma

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Anatomical Context for Breast Scirrhous Carcinoma

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MalaCards organs/tissues related to Breast Scirrhous Carcinoma:

33
Breast, Lymph node

Animal Models for Breast Scirrhous Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Breast Scirrhous Carcinoma:

38 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.6EGFR, ERBB2, ESR1, PGR
2MP:00053718.6EGFR, ERBB2, ESR1, PGR
3MP:00053698.6EGFR, ERBB2, ESR1, PGR
4MP:00053808.6EGFR, ERBB2, ESR1, PGR
5MP:00030128.5EGFR, ESR1, MUC1, PGR
6MP:00053818.4EGFR, ERBB2, ESR1, MUC1
7MP:00107717.9EGFR, ERBB2, ESR1, MUC1, PGR
8MP:00020067.9EGFR, ERBB2, ESR1, MUC1, PGR
9MP:00053767.6EGFR, ERBB2, ESR1, MUC1, PGR
10MP:00053797.2EGFR, ERBB2, ESR1, MUC1, PGR

Publications for Breast Scirrhous Carcinoma

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Articles related to Breast Scirrhous Carcinoma:

idTitleAuthorsYear
1
Establishment and characterization of HER2-positive cell line derived from pleural effusion of human breast scirrhous carcinoma. (19067762)
2008
2
Establishment and characterization of a cell line (NABCA) derived from metastatic lymph nodes of breast scirrhous carcinoma. (17257375)
2006

Variations for Breast Scirrhous Carcinoma

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Expression for genes affiliated with Breast Scirrhous Carcinoma

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Search GEO for disease gene expression data for Breast Scirrhous Carcinoma.

Pathways for genes affiliated with Breast Scirrhous Carcinoma

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GO Terms for genes affiliated with Breast Scirrhous Carcinoma

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Biological processes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of epithelial cell proliferationGO:00506799.9EGFR, ERBB2
2cellular response to estradiol stimulusGO:00713929.7EGFR, ESR1
3steroid hormone mediated signaling pathwayGO:00434019.7ESR1, PGR
4positive regulation of MAP kinase activityGO:00434069.6EGFR, ERBB2
5positive regulation of fibroblast proliferationGO:00481469.5EGFR, ESR1
6positive regulation of nitric oxide biosynthetic processGO:00454299.2EGFR, ESR1
7signal transductionGO:00071658.2EGFR, ERBB2, ESR1, PGR

Molecular functions related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:00047169.9EGFR, ERBB2
2protein phosphatase bindingGO:00199039.7EGFR, ERBB2
3steroid hormone receptor activityGO:00037079.7ESR1, PGR
4RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:00048799.7ESR1, PGR
5transmembrane receptor protein tyrosine kinase activityGO:00047149.5EGFR, ERBB2
6nitric-oxide synthase regulator activityGO:00302359.5EGFR, ESR1
7steroid bindingGO:00054969.5ESR1, PGR
8ATPase bindingGO:00511179.1ESR1, PGR
9RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009788.8ESR1, MUC1, PGR
10enzyme bindingGO:00198998.7EGFR, ESR1, PGR

Sources for Breast Scirrhous Carcinoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet