MCID: BRS042
MIFTS: 29

Breast Scirrhous Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Scirrhous Carcinoma

MalaCards integrated aliases for Breast Scirrhous Carcinoma:

Name: Breast Scirrhous Carcinoma 12 14
Infiltrating Carcinoma of Breast with Fibrotic Stroma 12
Scirrhous Carcinoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7578
NCIt 47 C7362
SNOMED-CT 64 254839007
UMLS 69 C0346151

Summaries for Breast Scirrhous Carcinoma

MalaCards based summary : Breast Scirrhous Carcinoma, also known as infiltrating carcinoma of breast with fibrotic stroma, is related to gastritis and kallmann syndrome. An important gene associated with Breast Scirrhous Carcinoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Development ERBB-family signaling and Endometrial cancer. Affiliated tissues include breast and lymph node, and related phenotypes are Decreased viability and limbs/digits/tail

Related Diseases for Breast Scirrhous Carcinoma

Diseases related to Breast Scirrhous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
id Related Disease Score Top Affiliating Genes
1 gastritis 10.4 ERBB2 PGR
2 kallmann syndrome 10.4 ERBB2 PGR
3 colon neuroendocrine neoplasm 10.4 ERBB2 PGR
4 infiltrating ureter transitional cell carcinoma 10.3 EGFR ERBB2
5 otitis externa 10.3 ERBB2 PGR
6 extragonadal nonseminomatous germ cell tumor 10.3 EGFR PGR
7 bile duct mucoepidermoid carcinoma 10.3 MUC1 PGR
8 amyloid tumor 10.3 ERBB2 PGR
9 exotropia 10.3 MUC1 PGR
10 mannose-binding lectin protein deficiency 10.3 MUC1 PGR
11 pyoderma 10.3 MUC1 PGR
12 papilloma 10.3 MUC1 PGR
13 occupational dermatitis 10.2 EGFR ERBB2
14 gorham's disease 10.2 EGFR ERBB2
15 sebaceous adenoma 10.2 MUC1 PGR
16 ovary neuroendocrine neoplasm 10.2 MUC1 PGR
17 breast signet ring cell adenocarcinoma 10.2 EGFR ERBB2
18 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 10.2 EGFR MUC1
19 mesenchymoma 10.2 MUC1 PGR
20 lip carcinoma in situ 10.2 MUC1 PGR
21 early congenital syphilis 10.2 EGFR ERBB2
22 luminal breast carcinoma 10.2 EGFR MUC1
23 pemphigus vulgaris, familial 10.2 ERBB2 MUC1
24 struma ovarii 10.2 MUC1 PGR
25 linitis plastica 10.1 MUC1 PGR
26 cystitis 10.1 MUC1 PGR
27 pulmonary subvalvular stenosis 10.1 EGFR ERBB2
28 cecum adenocarcinoma 10.1 EGFR MUC1
29 serous cystadenocarcinoma 10.1 MUC1 PGR
30 bartholin's gland benign neoplasm 10.1 ESR1 PGR
31 epidermolysa bullosa simplex with muscular dystrophy 10.1 EGFR MUC1
32 central nervous system organ benign neoplasm 10.1 ESR1 PGR
33 gallbladder leiomyoma 10.1 ESR1 PGR
34 lung adenoma 10.1 ESR1 PGR
35 fallopian tube benign neoplasm 10.1 ESR1 PGR
36 paranasal sinus disease 10.1 ESR1 PGR
37 dartoic leiomyoma 10.1 ESR1 PGR
38 urinary bladder inverted papilloma 10.1 ESR1 PGR
39 deafness, autosomal dominant 8/12 10.1 ESR1 PGR
40 intestinal perforation 10.1 ESR1 PGR
41 superficial basal cell carcinoma 10.1 ESR1 PGR
42 sarcomatoid squamous cell skin carcinoma 10.1 ESR1 PGR
43 pineal region meningioma 10.1 ESR1 PGR
44 ovarian mesodermal adenosarcoma 10.1 ESR1 PGR
45 endophthalmitis 10.1 ESR1 PGR
46 osteogenesis imperfecta 10.1 ESR1 PGR
47 chest wall lymphoma 10.1 ESR1 PGR
48 sebaceous adenocarcinoma 10.1 EGFR MUC1
49 cutaneous mucoepidermoid carcinoma 10.1 ESR1 PGR
50 retinal detachment 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Breast Scirrhous Carcinoma:



Diseases related to Breast Scirrhous Carcinoma

Symptoms & Phenotypes for Breast Scirrhous Carcinoma

GenomeRNAi Phenotypes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.56 EGFR
2 Decreased viability GR00221-A-1 9.56 ESR1 EGFR
3 Decreased viability GR00221-A-2 9.56 ESR1
4 Decreased viability GR00221-A-3 9.56 ERBB2
5 Decreased viability GR00221-A-4 9.56 ERBB2 ESR1 EGFR
6 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.33 ERBB2 MUC1 EGFR
7 Decreased viability with paclitaxel GR00179-A-1 8.8 ERBB2 EGFR
8 Decreased viability with paclitaxel GR00179-A-3 8.8 EGFR

MGI Mouse Phenotypes related to Breast Scirrhous Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.46 ESR1 PGR EGFR ERBB2
2 muscle MP:0005369 9.26 ESR1 PGR EGFR ERBB2
3 neoplasm MP:0002006 8.92 ESR1 PGR EGFR ERBB2

Drugs & Therapeutics for Breast Scirrhous Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Scirrhous Carcinoma

Genetic Tests for Breast Scirrhous Carcinoma

Anatomical Context for Breast Scirrhous Carcinoma

MalaCards organs/tissues related to Breast Scirrhous Carcinoma:

39
Breast, Lymph Node

Publications for Breast Scirrhous Carcinoma

Articles related to Breast Scirrhous Carcinoma:

id Title Authors Year
1
Establishment and characterization of HER2-positive cell line derived from pleural effusion of human breast scirrhous carcinoma. ( 19067762 )
2008
2
Establishment and characterization of a cell line (NABCA) derived from metastatic lymph nodes of breast scirrhous carcinoma. ( 17257375 )
2006

Variations for Breast Scirrhous Carcinoma

Expression for Breast Scirrhous Carcinoma

Search GEO for disease gene expression data for Breast Scirrhous Carcinoma.

Pathways for Breast Scirrhous Carcinoma

Pathways related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 EGFR ERBB2 MUC1
2
Show member pathways
11.98 EGFR ERBB2 ESR1 PGR
3
Show member pathways
11.76 EGFR ERBB2 ESR1
4 11.64 EGFR ERBB2 ESR1
5 11.43 EGFR ERBB2
6 11.42 EGFR ERBB2
7
Show member pathways
11.39 EGFR ESR1
8 11.37 EGFR ERBB2
9 11.34 EGFR ESR1
10 11.32 EGFR ERBB2
11 11.24 EGFR ERBB2
12 11.16 EGFR ESR1
13 11.11 EGFR ERBB2
14
Show member pathways
11.1 EGFR ERBB2 ESR1
15
Show member pathways
10.96 EGFR ERBB2 ESR1 PGR
16 10.92 EGFR ERBB2
17 10.88 EGFR ERBB2

GO Terms for Breast Scirrhous Carcinoma

Cellular components related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 EGFR ERBB2 MUC1

Biological processes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 regulation of transcription from RNA polymerase II promoter GO:0006357 9.72 EGFR ERBB2 ESR1
2 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.54 EGFR ERBB2
3 positive regulation of cell growth GO:0030307 9.52 EGFR ERBB2
4 positive regulation of epithelial cell proliferation GO:0050679 9.51 EGFR ERBB2
5 steroid hormone mediated signaling pathway GO:0043401 9.49 ESR1 PGR
6 positive regulation of MAP kinase activity GO:0043406 9.48 EGFR ERBB2
7 cellular response to growth factor stimulus GO:0071363 9.46 EGFR ERBB2
8 positive regulation of fibroblast proliferation GO:0048146 9.4 EGFR ESR1
9 cellular response to epidermal growth factor stimulus GO:0071364 9.37 EGFR ERBB2
10 cellular response to estradiol stimulus GO:0071392 9.32 EGFR ESR1
11 ERBB2 signaling pathway GO:0038128 9.26 EGFR ERBB2
12 regulation of cell motility GO:2000145 9.16 EGFR ERBB2
13 signal transduction by protein phosphorylation GO:0023014 9.13 ERBB2
14 regulation of ERK1 and ERK2 cascade GO:0070372 8.96 EGFR ERBB2
15 negative regulation of ERBB signaling pathway GO:1901185 8.62 EGFR ERBB2

Molecular functions related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.54 EGFR ESR1 PGR
2 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.5 ESR1 MUC1 PGR
3 ATPase binding GO:0051117 9.49 ESR1 PGR
4 protein phosphatase binding GO:0019903 9.48 EGFR ERBB2
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.46 EGFR ERBB2
6 steroid hormone receptor activity GO:0003707 9.43 ESR1 PGR
7 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.4 EGFR ERBB2
8 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.26 ESR1 PGR
9 steroid binding GO:0005496 9.16 ESR1 PGR
10 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.96 EGFR ERBB2
11 nitric-oxide synthase regulator activity GO:0030235 8.62 EGFR ESR1

Sources for Breast Scirrhous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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