MCID: BRS042
MIFTS: 31

Breast Scirrhous Carcinoma malady

Category: Cancer diseases

Aliases & Classifications for Breast Scirrhous Carcinoma

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Aliases & Descriptions for Breast Scirrhous Carcinoma:

Name: Breast Scirrhous Carcinoma 11 13
Infiltrating Carcinoma of Breast with Fibrotic Stroma 11
 
Scirrhous Carcinoma of Breast 11

Classifications:



External Ids:

Disease Ontology11 DOID:7578
SNOMED-CT60 254839007
NCIt43 C7362

Summaries for Breast Scirrhous Carcinoma

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MalaCards based summary: Breast Scirrhous Carcinoma, also known as infiltrating carcinoma of breast with fibrotic stroma, is related to kidney pelvis sarcomatoid transitional cell carcinoma and cutaneous mucoepidermoid carcinoma. An important gene associated with Breast Scirrhous Carcinoma is PGR (Progesterone Receptor), and among its related pathways are Agrin Interactions at Neuromuscular Junction and Central carbon metabolism in cancer. Affiliated tissues include breast and lymph node, and related mouse phenotypes are integument and muscle.

Related Diseases for Breast Scirrhous Carcinoma

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Diseases related to Breast Scirrhous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1kidney pelvis sarcomatoid transitional cell carcinoma10.4EGFR, ERBB2
2cutaneous mucoepidermoid carcinoma10.4ERBB2, PGR
3vaginal adenosarcoma10.4ERBB2, PGR
4mucinous cystadenocarcinoma10.4EGFR, ERBB2
5gastric squamous cell carcinoma10.4EGFR, ERBB2
6focal chorioretinitis10.3ERBB2, PGR
7retinitis10.3ERBB2, PGR
8adenosquamous carcinoma10.3EGFR, ERBB2
9scrotal carcinoma10.3EGFR, ERBB2
10ampulla of vater adenocarcinoma10.3EGFR, ERBB2
11early congenital syphilis10.3EGFR, ERBB2
12pemphigus vulgaris, familial10.3ERBB2, MUC1
13postpoliomyelitis syndrome10.3EGFR, ERBB2
14tonsil cancer10.2EGFR, ERBB2
15prostate adenoid cystic carcinoma10.2EGFR, PGR
16bronchiolo-alveolar adenocarcinoma10.2ERBB2, MUC1
17breast metaplastic carcinoma10.2MUC1, PGR
18distal monosomy 7q3610.2EGFR, MUC1
19endometriosis of pelvic peritoneum10.2MUC1, PGR
20kidney benign neoplasm10.2ERBB2, PGR
21congenital structural myopathy10.2MUC1, PGR
22luminal breast carcinoma10.2EGFR, MUC1
23serous surface papilloma10.2MUC1, PGR
24benign mesenchymoma10.2MUC1, PGR
25parachordoma10.2MUC1, PGR
26postcricoid region cancer10.2MUC1, PGR
27poliomyelitis10.2MUC1, PGR
28adult mesoblastic nephroma10.1EGFR, ERBB2
29breast pericanalicular fibroadenoma10.1MUC1, PGR
30submucosal invasive colon adenocarcinoma10.1EGFR, MUC1
31diplegia of upper limb10.1EGFR, ERBB2
32myoepithelial carcinoma10.1EGFR, MUC1
33cervix endometrial stromal tumor10.1ERBB2, MUC1
34chronic interstitial cystitis10.1MUC1, PGR
35papillary carcinoma10.1MUC1, PGR
36lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy10.1MUC1, PGR
37renal tubular acidosis, distal, autosomal recessive10.1EGFR, MUC1
38eyelid disease10.1ERBB2, ESR1
39extragonadal nonseminomatous germ cell tumor10.1ERBB2, ESR1
40ectodermal dysplasia with natal teeth, turnpenny type10.1ERBB2, MUC1
41plasmacytoma10.0EGFR, ERBB2
42pancreatic somatostatinoma10.0EGFR, MUC1
43vulvar angiokeratoma10.0ESR1, PGR
44richter's syndrome10.0EGFR, MUC1
45central nervous system organ benign neoplasm10.0ESR1, PGR
46fallopian tube benign neoplasm10.0ESR1, PGR
47appendix leiomyoma10.0ESR1, PGR
48mixed cell adenoma10.0ESR1, PGR
49tuberous sclerosis10.0ESR1, PGR
50deafness, autosomal dominant 8/1210.0ESR1, PGR

Graphical network of the top 20 diseases related to Breast Scirrhous Carcinoma:



Diseases related to breast scirrhous carcinoma

Symptoms for Breast Scirrhous Carcinoma

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Drugs & Therapeutics for Breast Scirrhous Carcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Breast Scirrhous Carcinoma

Genetic Tests for Breast Scirrhous Carcinoma

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Anatomical Context for Breast Scirrhous Carcinoma

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MalaCards organs/tissues related to Breast Scirrhous Carcinoma:

34
Breast, Lymph node

Animal Models for Breast Scirrhous Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Breast Scirrhous Carcinoma:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5EGFR, ERBB2, ESR1, PGR
2MP:00053698.3EGFR, ERBB2, ESR1, PGR
3MP:00020068.2EGFR, ERBB2, ESR1, PGR
4MP:00053808.2EGFR, ERBB2, ESR1, PGR
5MP:00053718.2EGFR, ERBB2, ESR1, PGR

Publications for Breast Scirrhous Carcinoma

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Articles related to Breast Scirrhous Carcinoma:

idTitleAuthorsYear
1
Establishment and characterization of HER2-positive cell line derived from pleural effusion of human breast scirrhous carcinoma. (19067762)
2008
2
Establishment and characterization of a cell line (NABCA) derived from metastatic lymph nodes of breast scirrhous carcinoma. (17257375)
2006

Variations for Breast Scirrhous Carcinoma

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Expression for genes affiliated with Breast Scirrhous Carcinoma

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Search GEO for disease gene expression data for Breast Scirrhous Carcinoma.

Pathways for genes affiliated with Breast Scirrhous Carcinoma

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GO Terms for genes affiliated with Breast Scirrhous Carcinoma

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Cellular components related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:00163248.8EGFR, ERBB2, MUC1

Biological processes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of phosphatidylinositol 3-kinase signalingGO:001406610.0EGFR, ERBB2
2ERBB2 signaling pathwayGO:00381289.9EGFR, ERBB2
3cellular response to epidermal growth factor stimulusGO:00713649.8EGFR, ERBB2
4cellular response to growth factor stimulusGO:00713639.7EGFR, ERBB2
5positive regulation of MAP kinase activityGO:00434069.7EGFR, ERBB2
6regulation of cell motilityGO:20001459.7EGFR, ERBB2
7positive regulation of cell growthGO:00303079.6EGFR, ERBB2
8cellular response to estradiol stimulusGO:00713929.5EGFR, ESR1
9positive regulation of fibroblast proliferationGO:00481469.5EGFR, ESR1
10positive regulation of epithelial cell proliferationGO:00506798.8EGFR, ERBB2, ESR1
11signal transductionGO:00071658.2EGFR, ERBB2, ESR1, PGR

Molecular functions related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1receptor signaling protein tyrosine kinase activityGO:000471610.0EGFR, ERBB2
2phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.9EGFR, ERBB2
3steroid hormone receptor activityGO:00037079.8ESR1, PGR
4transmembrane receptor protein tyrosine kinase activityGO:00047149.7EGFR, ERBB2
5nitric-oxide synthase regulator activityGO:00302359.6EGFR, ESR1
6steroid bindingGO:00054969.5ESR1, PGR
7ATPase bindingGO:00511179.2ESR1, PGR
8protein phosphatase bindingGO:00199039.1EGFR, ERBB2
9RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009788.7ESR1, MUC1, PGR
10enzyme bindingGO:00198998.7EGFR, ESR1, PGR

Sources for Breast Scirrhous Carcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet