MCID: BRT037
MIFTS: 27

Brittle Diabetes malady

Rare diseases category
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Summaries for Brittle Diabetes

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NIH Rare Diseases:42 Brittle diabetes is characterized by severe instability of blood glucose levels with frequent and unpredictable episodes of hypoglycemia and/or ketoacidosis that disrupt quality of life, often requiring frequent or prolonged hospitalizations. these unpredictable episodes are due to an absolute insulin dependency, affecting type 1 diabetics almost exclusively. brittle diabetes is most common in women in their twenties or thirties, but can occur at any age and in either gender. the condition may be caused by stress and hormonal inbalance, neglect of self-care (noncompliance), or underlying medical conditions such as malabsorption, delayed gastric emptying due to autonomic neuropathy, drug or alcohol use or abnormal insulin absorption or degradation. treatment is difficult and dependent upon the underlying cause. last updated: 8/22/2013

MalaCards based summary: Brittle Diabetes, also known as diabetes mellitus, insulin-dependent, is related to diabetes mellitus and alcohol abuse. An important gene associated with Brittle Diabetes is INS (insulin). The drugs insulin and insulin, aspart, human have been mentioned in the context of this disorder. Affiliated tissues include pancreas.

Wikipedia:65 Diabetes mellitus type more...

Aliases & Classifications for Brittle Diabetes

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS
See all sources

Brittle Diabetes, Aliases & Descriptions:

Name: Brittle Diabetes 42 44 62
Diabetes Mellitus, Insulin-Dependent 62
Diabetes Mellitus, Brittle 62
 
Brittle Diabetes Mellitus 42
Brittle Type 1 Diabetes 42
Labile Diabetes 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Brittle Diabetes

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Diseases related to Brittle Diabetes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus10.4
2alcohol abuse10.1
3peritonitis10.1
4insulin autoimmune syndrome10.1

Symptoms for Brittle Diabetes

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Genetic Tests for Brittle Diabetes

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Anatomical Context for Brittle Diabetes

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MalaCards organs/tissues related to Brittle Diabetes:

32
Pancreas

Animal Models for Brittle Diabetes or affiliated genes

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Publications for Brittle Diabetes

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Articles related to Brittle Diabetes:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
Brittle diabetes: psychopathological aspects. (24897966)
2014
2
Successful treatment of brittle diabetes following total pancreatectomy by islet allotransplantation: a case report. (23846941)
2013
3
Characterization of insulin antibodies by surface plasmon resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome. (24386337)
2013
4
Challenges for diabetic care: rural Africa & type 1 brittle diabetes. (21680778)
2011
5
The myth of brittle diabetes. (12908443)
2003
6
Brittle diabetes in the elderly. (11773367)
2002
7
Brittle diabetes in the elderly. (11691895)
2001
8
Hormonal response to stress in brittle diabetes. (8983089)
1996
9
Prevalence and characteristics of brittle diabetes in Britain. (8977963)
1996
10
Mortality and outcome of patients with brittle diabetes and recurrent ketoacidosis. (7916072)
1994
11
Brittle diabetes in the young. (1369810)
1992
12
The spectrum of brittle diabetes. (1433085)
1992
13
Brittle diabetes: a report of the First International Conference on Brittle Diabetes. (1511575)
1992
14
Brittle diabetes. (1760010)
1991
15
Course of brittle diabetes: 12 year follow up. (1904287)
1991
16
Successful treatment of unusual case of brittle diabetes with sulfated beef insulin. (1797500)
1991
17
A controlled study of psychoanalytic treatment of brittle diabetes. (1757442)
1991
18
Iatrogenic brittle diabetes: the hold-the-insulin decision. (1995280)
1991
19
Outcome of brittle diabetes. (1888928)
1991
20
Brittle diabetes in the elderly. (2527683)
1989
21
Hypoglycaemic brittle diabetes successfully managed by social worker intervention. (2527685)
1989
22
The natural history of brittle diabetes. (3042251)
1988
23
Brittle diabetes: strategies, diagnosis, and treatment. (3292175)
1988
24
Brittle diabetes in a drug and alcohol abuser. (3479175)
1987
25
The metabolic response to insulin deprivation in idiopathic brittle diabetes. (3527516)
1986
26
Another facet of brittle diabetes. (3537346)
1986
27
Brittle diabetes. (3971853)
1985
28
One minute with diabetes: brittle diabetes. (3910985)
1985
29
The etiology of incapacitating, brittle diabetes. (3971842)
1985
30
Brittle diabetes. (3929870)
1985
31
A clinical algorithm to determine the etiology of brittle diabetes. (3882369)
1985
32
Factitious brittle diabetes mellitus. (3922220)
1985
33
Brittle diabetes. (3929954)
1985
34
Continuous intraperitoneal insulin infusion in the management of severely brittle diabetes--a metabolic and clinical comparison with intravenous infusion. (6242795)
1984
35
Long-term continuous intraperitoneal insulin treatment in brittle diabetes. (6402060)
1983
36
Short-term control of brittle diabetes using a Biostator. (6812693)
1982
37
Brittle diabetes and stroke: a complicated rehabilitation problem. (7016066)
1981
38
Brittle diabetes: long-term control with a portable, continuous, intravenous insulin infusion system. (6797511)
1981
39
Management of severely brittle diabetes by continuous subcutaneous and intramuscular insulin infusions: evidence for a defect in subcutaneous insulin absorption. (6780019)
1981
40
Evaluation of a portable insulin infusion pump for outpatient management of brittle diabetes. (510142)
1979
41
Brittle diabetes. (118791)
1979
42
Clinical observation on brittle diabetes. (629631)
1978
43
Brittle diabetes. (330041)
1977
44
Brittle diabetes in pregnancy. (908461)
1977
45
Brittle diabetes. (4822969)
1974
46
Clinical value of ketone body determinations in brittle diabetes. (5038228)
1972
47
Brittle diabetes. The problem of the brittle diabetic. (5545170)
1971
48
The management of brittle diabetes mellitus in children. (4996757)
1971
49
TREATMENT OF UNSTABLE (BRITTLE) DIABETES IN CHILDREN AND ADULTS. (14312743)
1965
50
Brittle diabetes. (13377111)
1956

Variations for Brittle Diabetes

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Expression for genes affiliated with Brittle Diabetes

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Expression patterns in normal tissues for genes affiliated with Brittle Diabetes

Search GEO for disease gene expression data for Brittle Diabetes.

Pathways for genes affiliated with Brittle Diabetes

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Compounds for genes affiliated with Brittle Diabetes

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GO Terms for genes affiliated with Brittle Diabetes

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Products for genes affiliated with Brittle Diabetes

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  • Antibodies
  • Proteins
  • Lysates

Sources for Brittle Diabetes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet