MCID: BRT037
MIFTS: 21

Brittle Diabetes malady

Categories: Rare diseases

Aliases & Classifications for Brittle Diabetes

Aliases & Descriptions for Brittle Diabetes:

Name: Brittle Diabetes 50 52 69
Brittle Type 1 Diabetes Mellitus 69
Brittle Diabetes Mellitus 50
Brittle Type 1 Diabetes 50
Labile Diabetes 50

Classifications:



Summaries for Brittle Diabetes

NIH Rare Diseases : 50 brittle diabetes is a term that is sometimes used to describe hard-to-control diabetes (also called labile diabetes). it is characterized by wide variations or “swings” in blood glucose (sugar) in which blood glucose levels can quickly move from too high (hyperglycemia) to too low (hypoglycemia). these episodes are hard to predict and can disrupt quality of life. they can require frequent or lengthy hospitalizations and can be fatal. people with type 1 diabetes are at greatest risk. while many people with type 1 diabetes experience hypoglycemia, only a small proportion of people with type 1 diabetes experience the frequent blood glucose swings described as “brittle.” people with long-standing type 2 diabetes may also have difficulty controlling blood glucose, but few have these frequent swings. people of any age with diabetes can be affected with these frequent ups and downs in blood glucose levels. some research suggests that women may be affected more often than men.frequent episodes of hypoglycemia can lead to hypoglycemic unawareness and make the condition worse.  keeping diabetes under good control for at least several weeks can restore hypoglycemic awareness.  new technologies such as continuous glucose monitors and insulin pumps may help improve control.in diabetes, many factors can trigger frequent changes in blood glucose levels. for example, people who don’t test blood glucose or take diabetes medications as prescribed often experience significant fluctuations in blood glucose levels. other causes of unstable blood glucose levels include emotional stress, eating disorders, drug or alcohol use, malabsorption, gastroparesis, and celiac disease.   the development of new treatments for diabetes has made it easier for most people to control their blood glucose levels. artificial pancreas technology is currently being tested in clinical trials and aims to help people with type 1 diabetes more easily manage blood glucose levels. in 2016, the u.s. food and drug administration approved a hybrid model of an artificial pancreas, an automated system that requires users to adjust insulin intake at mealtimes. nih-funded research on islet cell transplantation has also shown promising results in restoring blood glucose control. this research specifically includes people who have experienced episodes of severe hypoglycemia. last updated: 3/13/2017

MalaCards based summary : Brittle Diabetes, also known as brittle type 1 diabetes mellitus, is related to alcohol abuse and hyperglycemia. An important gene associated with Brittle Diabetes is INS (Insulin). The drugs Zinc and Insulin Aspart have been mentioned in the context of this disorder. Affiliated tissues include pancreas and testes.

Related Diseases for Brittle Diabetes

Diseases related to Brittle Diabetes via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 alcohol abuse 9.8
2 hyperglycemia 9.8
3 lipodystrophy 9.8
4 peritonitis 9.8
5 insulin autoimmune syndrome 9.8

Graphical network of the top 20 diseases related to Brittle Diabetes:



Diseases related to Brittle Diabetes

Symptoms & Phenotypes for Brittle Diabetes

Drugs & Therapeutics for Brittle Diabetes

Drugs for Brittle Diabetes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved Phase 3,Phase 2 7440-66-6 32051 23994
2
Insulin Aspart Approved Phase 3,Phase 2 116094-23-6 16132418
3 Hypoglycemic Agents Phase 3,Phase 2,Phase 1
4 insulin Phase 3,Phase 2
5 Insulin, Globin Zinc Phase 3,Phase 2
6
Tacrolimus Approved, Investigational Phase 2,Phase 1 104987-11-3 445643 439492
7
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
8
Mycophenolate mofetil Approved, Investigational Phase 1, Phase 2 128794-94-5 5281078
9
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
10
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
11
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
12
Daclizumab Approved, Investigational Phase 2 152923-56-3
13
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
14
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
15
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
16 Prednisolone acetate Phase 1, Phase 2
17 Anesthetics Phase 2
18 Anti-Bacterial Agents Phase 2
19 Prednisolone hemisuccinate Phase 1, Phase 2
20 Prednisolone phosphate Phase 1, Phase 2
21 Anti-Infective Agents Phase 2
22 Immunosuppressive Agents Phase 1, Phase 2
23 Antifungal Agents Phase 2
24 Antibiotics, Antitubercular Phase 2
25 Methylprednisolone acetate Phase 1, Phase 2
26 Methylprednisolone Hemisuccinate Phase 1, Phase 2
27 Calcineurin Inhibitors Phase 1, Phase 2
28 Liver Extracts Phase 1, Phase 2
29
Infliximab Approved 170277-31-3

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes Recruiting NCT02854696 Phase 3
2 Effects of Pulsed Intravenous (IV) Insulin on Brittle and Uncontrolled Diabetes Terminated NCT01029444 Phase 3
3 Effects of Pulsatile Intravenous Insulin Therapy on Metabolic Integrity in Patients With Diabetes Mellitus Terminated NCT00539409 Phase 2, Phase 3
4 Human Islet Transplantation in Brittle Type 1 Diabetes Mellitus. The GRAGIL 2 Study. Completed NCT00321256 Phase 1, Phase 2
5 Calcineurin Inhibitor (CNI)-Free Immunosuppressive Regimen in T1D Patients Receiving Islet Transplantation Completed NCT01346085 Phase 1, Phase 2
6 Effectiveness of Oral Insulin in Unstable Type 1 Diabetes Patients Completed NCT00867594 Phase 2
7 Islet Allotransplantation With Steroid Free Immunosuppression Completed NCT00446264 Phase 2
8 Allogenic Islet Cell Transplantation Active, not recruiting NCT00160732 Phase 1, Phase 2
9 UVA Islet Cell Transplantation in Patients With Type I Diabetes Unknown status NCT00605592 Phase 1
10 Bone Marrow Autotransplantation in Type 1 Diabetes Completed NCT00821899
11 Intraperitoneal vs Subcutaneous Insulin Administration in Type 1 Diabetes Mellitus Completed NCT01621308
12 Nephrologic Prognosis 10 Years After Diabetes Cell Therapy Recruiting NCT02627690
13 Islet Transplantation in Patients With "Brittle" Type I Diabetes Recruiting NCT01630850
14 Islet Transplant for Type 1 or Surgical Diabetes No longer available NCT01606475

Search NIH Clinical Center for Brittle Diabetes

Genetic Tests for Brittle Diabetes

Anatomical Context for Brittle Diabetes

MalaCards organs/tissues related to Brittle Diabetes:

39
Pancreas, Testes

Publications for Brittle Diabetes

Articles related to Brittle Diabetes:

(show top 50) (show all 73)
id Title Authors Year
1
New Methods in Exploring Old Topics: Case Studying Brittle Diabetes in the Family Context. ( 26634215 )
2016
2
Brittle diabetes: Psychopathology and personality. ( 27524279 )
2016
3
Sweet and brittle - Diabetes mellitus and the skeleton. ( 26363338 )
2015
4
Brittle diabetes: psychopathological aspects. ( 24897966 )
2014
5
Characterization of insulin antibodies by surface plasmon resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome. ( 24386337 )
2013
6
Perioperative glycemic control using an artificial endocrine pancreas in patients undergoing total pancreatectomy: tight glycemic control may be justified in order to avoid brittle diabetes. ( 23442241 )
2013
7
Successful treatment of brittle diabetes following total pancreatectomy by islet allotransplantation: a case report. ( 23846941 )
2013
8
Challenges for diabetic care: rural Africa & type 1 brittle diabetes. ( 21680778 )
2011
9
[Does brittle diabetes exist as a clinical entity?]. ( 19649386 )
2009
10
A case of hypoglycemic brittle diabetes with peripheral edema successfully managed by conversion from insulin lispro to insulin aspart. ( 18676048 )
2008
11
Dirty electricity elevates blood sugar among electrically sensitive diabetics and may explain brittle diabetes. ( 18568931 )
2008
12
Over 500 solitary pancreas transplants in nonuremic patients with brittle diabetes mellitus. ( 18192910 )
2008
13
Management strategies for brittle diabetes. ( 17072232 )
2006
14
Usefulness of measuring the gastric emptying time in a case of brittle diabetes. ( 15515755 )
2004
15
Quetiapine in the successful treatment of psychosis and comorbid brittle diabetes mellitus: a case report. ( 15666960 )
2004
16
The myth of brittle diabetes. ( 12908443 )
2003
17
Brittle diabetes in the elderly. ( 11773367 )
2002
18
[Psychosocial predictors of metabolic instability in brittle diabetes--a multivariate time series analysis]. ( 11447656 )
2001
19
Brittle diabetes in the elderly. ( 11691895 )
2001
20
Brittle diabetes characterised by recurrent hypoglycaemia. ( 10566119 )
1999
21
Brittle diabetes revisited: the Third Arnold Bloom Memorial Lecture. ( 9047086 )
1997
22
Hormonal response to stress in brittle diabetes. ( 8983089 )
1996
23
Prevalence and characteristics of brittle diabetes in Britain. ( 8977963 )
1996
24
Brittle diabetes: etiology and treatment. ( 7671100 )
1995
25
Mortality and outcome of patients with brittle diabetes and recurrent ketoacidosis. ( 7916072 )
1994
26
Brittle diabetes: a report of the First International Conference on Brittle Diabetes. ( 1511575 )
1992
27
The spectrum of brittle diabetes. ( 1433085 )
1992
28
Brittle diabetes in the young. ( 1369810 )
1992
29
Successful treatment of unusual case of brittle diabetes with sulfated beef insulin. ( 1797500 )
1991
30
Brittle diabetes. ( 1760010 )
1991
31
Iatrogenic brittle diabetes: the hold-the-insulin decision. ( 1995280 )
1991
32
Course of brittle diabetes: 12 year follow up. ( 1904287 )
1991
33
Outcome of brittle diabetes. ( 1888928 )
1991
34
A controlled study of psychoanalytic treatment of brittle diabetes. ( 1757442 )
1991
35
Hypoglycaemic brittle diabetes successfully managed by social worker intervention. ( 2527685 )
1989
36
Brittle diabetes in the elderly. ( 2527683 )
1989
37
The natural history of brittle diabetes. ( 3042251 )
1988
38
Brittle diabetes: strategies, diagnosis, and treatment. ( 3292175 )
1988
39
Brittle diabetes in a drug and alcohol abuser. ( 3479175 )
1987
40
The management of severe brittle diabetes with "Infusaid" implantable pumps. ( 3709039 )
1986
41
Another facet of brittle diabetes. ( 3537346 )
1986
42
The metabolic response to insulin deprivation in idiopathic brittle diabetes. ( 3527516 )
1986
43
Brittle diabetes--present concepts. ( 4054447 )
1985
44
One minute with diabetes: brittle diabetes. ( 3910985 )
1985
45
The etiology of incapacitating, brittle diabetes. ( 3971842 )
1985
46
Brittle diabetes. ( 3929954 )
1985
47
Factitious brittle diabetes mellitus. ( 3922220 )
1985
48
Brittle diabetes. ( 3971853 )
1985
49
Brittle diabetes. ( 3929870 )
1985
50
Continuous intravenous insulin infusion in the management of brittle diabetes: etiologic and therapeutic implications. ( 3971843 )
1985

Variations for Brittle Diabetes

Expression for Brittle Diabetes

Search GEO for disease gene expression data for Brittle Diabetes.

Pathways for Brittle Diabetes

GO Terms for Brittle Diabetes

Sources for Brittle Diabetes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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