MCID: BRT037
MIFTS: 25

Brittle Diabetes

Categories: Rare diseases

Aliases & Classifications for Brittle Diabetes

MalaCards integrated aliases for Brittle Diabetes:

Name: Brittle Diabetes 49 51 69
Brittle Type 1 Diabetes Mellitus 69
Brittle Diabetes Mellitus 49
Brittle Type 1 Diabetes 49
Labile Diabetes 49

Classifications:



External Ids:

Summaries for Brittle Diabetes

NIH Rare Diseases : 49 Brittle diabetes is a term that is sometimes used to describe hard-to-control diabetes (also called labile diabetes). It is characterized by wide variations or “swings” in blood glucose (sugar) in which blood glucose levels can quickly move from too high (hyperglycemia) to too low (hypoglycemia). These episodes are hard to predict and can disrupt quality of life. They can require frequent or lengthy hospitalizations and can be fatal. People with type 1 diabetes are at greatest risk. While many people with type 1 diabetes experience hypoglycemia, only a small proportion of people with type 1 diabetes experience the frequent blood glucose swings described as “brittle.” People with long-standing type 2 diabetes may also have difficulty controlling blood glucose, but few have these frequent swings. People of any age with diabetes can be affected with these frequent ups and downs in blood glucose levels. Some research suggests that women may be affected more often than men.Frequent episodes of hypoglycemia can lead to hypoglycemic unawareness and make the condition worse.  Keeping diabetes under good control for at least several weeks can restore hypoglycemic awareness.  New technologies such as continuous glucose monitors and insulin pumps may help improve control.In diabetes, many factors can trigger frequent changes in blood glucose levels. For example, people who don’t test blood glucose or take diabetes medications as prescribed often experience significant fluctuations in blood glucose levels. Other causes of unstable blood glucose levels include emotional stress, eating disorders, drug or alcohol use, malabsorption, gastroparesis, and celiac disease.   The development of new treatments for diabetes has made it easier for most people to control their blood glucose levels. Artificial pancreas technology is currently being tested in clinical trials and aims to help people with type 1 diabetes more easily manage blood glucose levels. In 2016, the U.S. Food and Drug Administration approved a hybrid model of an artificial pancreas, an automated system that requires users to adjust insulin intake at mealtimes. NIH-funded research on islet cell transplantation has also shown promising results in restoring blood glucose control. This research specifically includes people who have experienced episodes of severe hypoglycemia. Last updated: 3/13/2017

MalaCards based summary : Brittle Diabetes, also known as brittle type 1 diabetes mellitus, is related to diabetes mellitus and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Brittle Diabetes is INS (Insulin). The drugs Zinc and Insulin Aspart have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and bone.

Related Diseases for Brittle Diabetes

Diseases related to Brittle Diabetes via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 diabetes mellitus 10.2
2 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
3 hydrops, lactic acidosis, and sideroblastic anemia 9.8
4 alcohol abuse 9.8
5 hyperglycemia 9.8
6 lipodystrophy 9.8
7 peritonitis 9.8
8 insulin autoimmune syndrome 9.8

Graphical network of the top 20 diseases related to Brittle Diabetes:



Diseases related to Brittle Diabetes

Symptoms & Phenotypes for Brittle Diabetes

Drugs & Therapeutics for Brittle Diabetes

Drugs for Brittle Diabetes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 3,Phase 2 7440-66-6 32051 23994
2
Insulin Aspart Approved Phase 3,Phase 2 116094-23-6 16132418
3 Hypoglycemic Agents Phase 3,Phase 2,Phase 1
4 insulin Phase 3,Phase 2
5 Insulin, Globin Zinc Phase 3,Phase 2
6
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
7
Mycophenolate mofetil Approved, Investigational Phase 1, Phase 2 128794-94-5 5281078
8
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
9
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
10
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
11
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
12
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
13 Prednisolone acetate Phase 1, Phase 2
14 Methylprednisolone acetate Phase 1, Phase 2
15 Methylprednisolone Hemisuccinate Phase 1, Phase 2
16 Prednisolone hemisuccinate Phase 1, Phase 2
17 Immunosuppressive Agents Phase 1, Phase 2
18 Prednisolone phosphate Phase 1, Phase 2
19 Calcineurin Inhibitors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes Recruiting NCT02854696 Phase 3 best medical care
2 Effects of Pulsed Intravenous (IV) Insulin on Brittle and Uncontrolled Diabetes Terminated NCT01029444 Phase 3
3 Effects of Pulsatile Intravenous Insulin Therapy on Metabolic Integrity in Patients With Diabetes Mellitus Terminated NCT00539409 Phase 2, Phase 3
4 Human Islet Transplantation in Brittle Type 1 Diabetes Mellitus. The GRAGIL 2 Study. Completed NCT00321256 Phase 1, Phase 2
5 Calcineurin Inhibitor (CNI)-Free Immunosuppressive Regimen in T1D Patients Receiving Islet Transplantation Completed NCT01346085 Phase 1, Phase 2 CNI free immunosuppression
6 UVA Islet Cell Transplantation in Patients With Type I Diabetes Unknown status NCT00605592 Phase 1
7 Bone Marrow Autotransplantation in Type 1 Diabetes Completed NCT00821899
8 Nephrologic Prognosis 10 Years After Diabetes Cell Therapy Recruiting NCT02627690
9 Islet Transplant for Type 1 or Surgical Diabetes No longer available NCT01606475

Search NIH Clinical Center for Brittle Diabetes

Genetic Tests for Brittle Diabetes

Anatomical Context for Brittle Diabetes

MalaCards organs/tissues related to Brittle Diabetes:

38
Pancreas, Testes, Bone, Bone Marrow

Publications for Brittle Diabetes

Articles related to Brittle Diabetes:

(show top 50) (show all 73)
# Title Authors Year
1
Brittle diabetes: Psychopathology and personality. ( 27524279 )
2016
2
New Methods in Exploring Old Topics: Case Studying Brittle Diabetes in the Family Context. ( 26634215 )
2016
3
Sweet and brittle - Diabetes mellitus and the skeleton. ( 26363338 )
2015
4
Brittle diabetes: psychopathological aspects. ( 24897966 )
2014
5
Perioperative glycemic control using an artificial endocrine pancreas in patients undergoing total pancreatectomy: tight glycemic control may be justified in order to avoid brittle diabetes. ( 23442241 )
2013
6
Successful treatment of brittle diabetes following total pancreatectomy by islet allotransplantation: a case report. ( 23846941 )
2013
7
Characterization of insulin antibodies by surface plasmon resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome. ( 24386337 )
2013
8
Challenges for diabetic care: rural Africa & type 1 brittle diabetes. ( 21680778 )
2011
9
[Does brittle diabetes exist as a clinical entity?]. ( 19649386 )
2009
10
A case of hypoglycemic brittle diabetes with peripheral edema successfully managed by conversion from insulin lispro to insulin aspart. ( 18676048 )
2008
11
Over 500 solitary pancreas transplants in nonuremic patients with brittle diabetes mellitus. ( 18192910 )
2008
12
Dirty electricity elevates blood sugar among electrically sensitive diabetics and may explain brittle diabetes. ( 18568931 )
2008
13
Management strategies for brittle diabetes. ( 17072232 )
2006
14
Quetiapine in the successful treatment of psychosis and comorbid brittle diabetes mellitus: a case report. ( 15666960 )
2004
15
Usefulness of measuring the gastric emptying time in a case of brittle diabetes. ( 15515755 )
2004
16
The myth of brittle diabetes. ( 12908443 )
2003
17
Brittle diabetes in the elderly. ( 11773367 )
2002
18
Brittle diabetes in the elderly. ( 11691895 )
2001
19
[Psychosocial predictors of metabolic instability in brittle diabetes--a multivariate time series analysis]. ( 11447656 )
2001
20
Brittle diabetes characterised by recurrent hypoglycaemia. ( 10566119 )
1999
21
Brittle diabetes revisited: the Third Arnold Bloom Memorial Lecture. ( 9047086 )
1997
22
Hormonal response to stress in brittle diabetes. ( 8983089 )
1996
23
Prevalence and characteristics of brittle diabetes in Britain. ( 8977963 )
1996
24
Brittle diabetes: etiology and treatment. ( 7671100 )
1995
25
Mortality and outcome of patients with brittle diabetes and recurrent ketoacidosis. ( 7916072 )
1994
26
The spectrum of brittle diabetes. ( 1433085 )
1992
27
Brittle diabetes in the young. ( 1369810 )
1992
28
Brittle diabetes: a report of the First International Conference on Brittle Diabetes. ( 1511575 )
1992
29
Outcome of brittle diabetes. ( 1888928 )
1991
30
A controlled study of psychoanalytic treatment of brittle diabetes. ( 1757442 )
1991
31
Iatrogenic brittle diabetes: the hold-the-insulin decision. ( 1995280 )
1991
32
Course of brittle diabetes: 12 year follow up. ( 1904287 )
1991
33
Brittle diabetes. ( 1760010 )
1991
34
Successful treatment of unusual case of brittle diabetes with sulfated beef insulin. ( 1797500 )
1991
35
Hypoglycaemic brittle diabetes successfully managed by social worker intervention. ( 2527685 )
1989
36
Brittle diabetes in the elderly. ( 2527683 )
1989
37
The natural history of brittle diabetes. ( 3042251 )
1988
38
Brittle diabetes: strategies, diagnosis, and treatment. ( 3292175 )
1988
39
Brittle diabetes in a drug and alcohol abuser. ( 3479175 )
1987
40
The metabolic response to insulin deprivation in idiopathic brittle diabetes. ( 3527516 )
1986
41
The management of severe brittle diabetes with "Infusaid" implantable pumps. ( 3709039 )
1986
42
Another facet of brittle diabetes. ( 3537346 )
1986
43
Continuous intravenous insulin infusion in the management of brittle diabetes: etiologic and therapeutic implications. ( 3971843 )
1985
44
Brittle diabetes--present concepts. ( 4054447 )
1985
45
The etiology of incapacitating, brittle diabetes. ( 3971842 )
1985
46
Brittle diabetes. ( 3971853 )
1985
47
A clinical algorithm to determine the etiology of brittle diabetes. ( 3882369 )
1985
48
One minute with diabetes: brittle diabetes. ( 3910985 )
1985
49
Brittle diabetes. ( 3929870 )
1985
50
Factitious brittle diabetes mellitus. ( 3922220 )
1985

Variations for Brittle Diabetes

Expression for Brittle Diabetes

Search GEO for disease gene expression data for Brittle Diabetes.

Pathways for Brittle Diabetes

GO Terms for Brittle Diabetes

Sources for Brittle Diabetes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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