Bronchial Asthma malady

MalaCards: Bronchial Asthma, also known as asthma, is related to asthma and allergic asthma. An important gene associated with Bronchial Asthma is LTC4S (leukotriene C4 synthase), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and NFAT Signaling and Lymphocyte Interactions. The drugs metaproterenol and ephedrine sulfate and the compounds glucose and calcium have been mentioned in the context of this disorder. Affiliated tissues include brain, smooth muscle and skeletal muscle, and related mouse phenotypes are respiratory system and hematopoietic system.

bronchial asthma 7 asthma 43

Diseases related to bronchial asthma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 935)

id	Related Disease	Score	Top Affiliating Genes
1	asthma	42.2	SCGB1A1, SCGB3A2, IL13, CCL11, HNMT, TNF
2	allergic asthma	35.6	PDE3B, SERPINB4, VCAM1, BDNF, SCGB1A1, MS4A2
3	allergic rhinitis	35.3	SELE, VIP, VCAM1, IL13, IL4, IL5
4	bronchitis	33.6	VIP, CFTR, MPO, IL5, IL8, IL9
5	cough variant asthma	33.5	IL10, IL4, IL5, IGHE, RNASE3, ACE
6	atopic dermatitis	33.3	KITLG, SELE, SELL, SELP, VIP, NAT2
7	intrinsic asthma	33.1	FCER2, IL3, IL4, IL5, CCL5, IGES
8	kimura disease	31.0	IL13, IL4, IL5, CCL11, CCR3, IGES
9	allergic bronchopulmonary aspergillosis	31.0	SFTPD, CFTR, IL4, IL5, MBL2, IGES
10	chronic obstructive pulmonary disease	30.9	SFTPD, NAT2, PARP1, SCGB1A1, CHRM3, MUC5AC
11	rheumatoid arthritis	30.9	IL1R1, IL1RN, MBL2, HLA-DRB1, TNFRSF1A, SRF
12	status asthmaticus	30.9	CHKB, MUC5AC, MMP9, IL1R1, IL1RN, IL5
13	arthritis	30.3	SELL, VIP, IL1A, IL1B, IL6, IL8
14	churg-strauss syndrome	30.2	CHIA, MPO, IL10, IL13, IL2, IL2RA
15	food allergy	30.2	FOXP3, IL13, IL4, IL5, CCL11, IGES
16	eosinophilic pneumonia	30.0	CD69, IL13, IL3, IL5, CCL11, CCL5
17	eczema	29.8	SELE, VIP, CMA1, MS4A2, MPO, CD79A
18	tuberculosis	29.6	IL10, IL1B, IL1RN, IL4, MBL2, IFNG
19	interleukin receptor	29.4	FOS, IL10, IL1B, IL1R1, IL1RN, IL4
20	hypereosinophilic syndrome	29.2	JUN, CD69, IL13, IL2, IL2RA, IL3
21	pulmonary emphysema	29.1	SFTPD, VEGFA, MMP14, MMP8, MMP9, IL18
22	eosinophilia	29.0	PDE3B, SFTPD, SELL, VCAM1, CHIA, MS4A2
23	glucocorticoid resistance	28.6	JUN, CD28, FOS, MIF, IL10, IL1A
24	rhinitis	28.5	KITLG, SFTPD, SELE, SELL, VIP, VEGFA
25	bronchiolitis	28.4	KITLG, SFTPD, SELE, SELL, VIP, VCAM1
26	alcoholism	28.3	CFTR, GSR, IL1RN, HTR2A, HNMT, CYP2E1
27	gamma chain deficiency	28.2	KITLG, IL13, IL2, IL2RA, IL4, IL4R
28	vernal keratoconjunctivitis	28.2	VCAM1, CMA1, MMP9, IL13, IL3, IL4
29	mastocytosis	28.0	KITLG, CMA1, BGLAP, MPO, CD69, FCER2
30	microscopic polyangiitis	27.9	SELE, MPO, IL10, IL2RA, HLA-B, HLA-DQB1
31	common cold	27.6	SELP, CHIA, CFTR, IL1R1, IL5, IL8
32	obstructive lung disease	27.5	IGHE, ALB, CALCA, TNF, RNASE3, ACE
33	congestive heart failure	27.5	PDE3B, CHKB, XDH, MMP8, ANGPT1, PPBP
34	hyper-ige syndrome	27.5	SELL, MMP8, MMP9, IL10, IL13, IL4
35	atopy	27.5	KITLG, SELP, NAT2, VEGFA, CMA1, SCGB1A1
36	b-cell lymphomas	27.2	PARP1, CD14, CD80, CD44, ITGA4, ITGB2
37	bronchiectasis	27.0	CFTR, MPO, CD79A, CD14, CD4, MMP14
38	aspergillosis	26.6	SFTPD, CFTR, CD79A, CD4, IL10, IL1A
39	pulmonary function	26.6	LEP, CHIA, CFTR, CEACAM3, MPO, CD14
40	t-cell leukemia	26.6	JUN, CD28, CD4, ITGA4, FOS, FOXP3
41	dermatitis	26.3	PDE3B, KITLG, SFTPD, SELE, SELL, SELP
42	glioblastoma	25.9	VEGFA, PARP1, CD80, CD44, FLT1, GSTP1
43	sepsis	25.8	SFTPD, SELE, SELL, SELP, SERPINA7, PAFAH1B1
44	juvenile rheumatoid arthritis	25.5	BGLAP, IL1A, IL1R1, IL1RN, IL2RA, IL6
45	alpha 1-antitrypsin deficiency	25.4	VEGFA, CFTR, MPO, CD14, GSTP1, IL10
46	urticaria	25.3	KITLG, SELE, SELP, VEGFA, VCAM1, CMA1
47	keratoconjunctivitis	25.1	VEGFA, VCAM1, CMA1, MUC5AC, CFTR, CD79A
48	otitis media	25.1	SELL, VCAM1, PARP1, MUC5AC, MPO, CD79A
49	pulmonary disease	24.7	SFTPD, SELE, SELL, SELP, NAT2, VEGFA
50	bronchiolitis obliterans	24.6	SFTPD, SCGB1A1, CHKB, MMP8, MMP9, IL10

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 [re100] antiasthma/bronchodilators, [re101] anti-inflammatories,inhalation, [re102] bronchodilators,sympathomimetic,inhalation, [re103] bronchodilators,sympathomimetic,oral, [re104] bronchodilators,xanthine-derivative, [re105] bronchodilators,anticholinergic, [re108] antiasthma,antileukotrienes, [re109] antiasthma,other, albuterol, albuterol so4 pwdr [va product], albuterol sulfate, aminophylline, aminophylline dihydrate, aminophylline pwdr [va product], ephedra, ephedrine, ephedrine hydrochloride, ephedrine sulfate, ephedrine tannate, glycerol,iodinated, isoetharine, isoetharine hydrochloride, isoetharine mesylate, metaproterenol, metaproterenol sulfate, montelukast, montelukast sodium, oleandomycin (as troleandomycin), oxtriphylline, pirbuterol, pirbuterol acetate, pseudoephedrine, pseudoephedrine hydrochloride, pseudoephedrine sulfate, terbutaline, terbutaline sulfate, theophylline, theophylline calcium salicylate, theophylline sodium glycinate, theophylline,anhydrous

MalaCards organs/tissues related to bronchial asthma:

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MGI Mouse Phenotypes related to bronchial asthma:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.9	SFTPD, SELL, SELP, BDNF, SCGB1A1, CHRM3
2	hematopoietic system phenotype	MP:0005397	10.9	CD28, CD69, CD86, CD80, ITGA2, FOXP3
3	endocrine/exocrine gland phenotype	MP:0005379	10.5	SELL, PAFAH1B1, CHRM3, XDH, IL2, IFNG
4	renal/urinary system phenotype	MP:0005367	10.0	SELP, CLCN3, SCGB1A1, CHGA, CHRM3, ATP2A2
5	immune system phenotype	MP:0005387	9.7	SELL, SELP, CMA1, CLCN3, MUC5AC, XDH
6	integument phenotype	MP:0010771	9.7	PDE3B, KITLG, SELP, PARP1, BDNF, XDH
7	embryogenesis phenotype	MP:0005380	9.5	PARP1, ITGA4, FOS, IL5, IKBKAP, ALPP
8	no phenotypic analysis	MP:0003012	8.6	VEGFA, VCAM1, PARP1, BDNF, CD79A, CD69
9	nervous system phenotype	MP:0003631	8.6	KITLG, SELP, CLCN3, PAFAH1B1, PARP1, BDNF
10	liver/biliary system phenotype	MP:0005370	8.4	VEGFA, CLCN3, CHRM3, CFTR, INS, IL1R1
11	digestive/alimentary phenotype	MP:0005381	8.1	KITLG, VEGFA, CLCN3, BDNF, LEP, CHRM3
12	reproductive system phenotype	MP:0005389	8.0	VIP, VEGFA, CLCN3, PAFAH1B1, LEP, ATP2A2
13	skeleton phenotype	MP:0005390	7.9	KITLG, VEGFA, CLCN3, LEP, JUN, CD69
14	adipose tissue phenotype	MP:0005375	7.9	PDE3B, CLCN3, LEP, CHRM3, XDH, CD14
15	growth/size phenotype	MP:0005378	7.7	PDE3B, KITLG, SFTPD, SELE, SELP, VCAM1
16	normal phenotype	MP:0002873	7.7	SELE, VIP, VEGFA, BDNF, SCGB1A1, CFTR
17	muscle phenotype	MP:0005369	7.7	VEGFA, LEP, CHKB, CHRM3, XDH, ATP2A3
18	tumorigenesis	MP:0002006	7.4	KITLG, SELL, SCGB1A1, LEP, ATP2A2, CD44
19	mortality/aging	MP:0010768	7.2	KITLG, SFTPD, SELE, SELP, VEGFA, VCAM1
20	behavior/neurological phenotype	MP:0005386	6.7	SELE, SELP, VIP, CLCN3, PAFAH1B1, BDNF
21	vision/eye phenotype	MP:0005391	6.6	KITLG, SELE, SELP, VEGFA, CLCN3, BDNF
22	homeostasis/metabolism phenotype	MP:0005376	5.9	PDE3B, KITLG, SFTPD, SELE, SELL, SELP
23	cellular phenotype	MP:0005384	5.5	KITLG, SELE, SELL, SELP, VEGFA, VCAM1
24	cardiovascular system phenotype	MP:0005385	5.4	KITLG, SELE, SELL, SELP, VEGFA, VCAM1

Articles related to bronchial asthma:

(show top 50)    (show all 358)

id	Title	Authors	Year	Affiliating Genes
1	M31R and R335C polymorphic variants of the IL8RA gen e in Russian and Buryat patients with atopic bronchial asthma]. (22117410)	voron'ko O.E.... Bodoev N.V.	2011	CXCR2
2	The mechanism of mucus production in bronchial asthma . (19689269)	Izuhara K.... Aizawa H.	2009	CLCN3
3	Concentration of IL-10, IL-13 and IFN-gamma cytokines in supernatants of microcultured CD4+ and NK cells in patients with non-allergic bronchial asthma (18634243)	Stasiak-Barmuta A.... Alifier M.	2008	IFNG, IL10, IL13
4	Correlation between genetic polymorphism of cytokine genes, plasma protein levels and bronchial asthma in the Han people in northern China. (18773331)	Xiaomin L.... Yingmei Z.	2008	TNF, IL6, IL2
5	A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma. (18204779)	Bai C.... Kondo N.	2008	ALOX5
6	VEGF, angiopoietin-1 and -2 in bronchial asthma: new molecular targets in airway angiogenesis and microvascular remodeling. (19075960)	Kanazawa H.	2007	ANGPT1
7	Efficacy of intramuscular BCG polysaccharide nucleotide on mild to moderate bronchial asthma accompanied with allergic rhinitis: a randomized, double blind, placebo-controlled study. (16232343)	Li J.... Zhong N.S.	2005	IGHE
8	Platelet function and fibrinolytic activity in patients with bronchial asthma. (15678276)	Tutluoglu B.... Ulutin T.	2005	PF4
9	Association of G-308A TNF-alpha polymorphism with bronchial asthma in a North Indian population. (16393721)	Gupta V.... Sehajpal P.K.	2005	TNF
10	State of the endothelial system and expression of tissue hypoxia in children with bronchial asthma of atopic geneses (16052054)	Barbakadze T.R.... Tatulashvili D.R.	2005	EDN1
11	Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. (15356575)	Heinzmann A.... Deichmann K.A.	2004	IL8
12	In vitro responsiveness to IL-18 in combination with IL-12 or IL-2 by PBMC from patients with bronchial asthma and atopic dermatitis. (15093553)	El-Mezayen R.E.... Matsumoto T.	2004	IL2, IL18
13	Enzymes of purine metabolism of lymphocytes and eosinophiles in bronchial asthma (12774669)	Andrushkevich V.V.... Chukhnova D.L.	2003	ADA, NT5E, XDH
14	Eotaxin level in induced sputum is increased in patients with bronchial asthma and in smokers. (14732790)	Yamamoto K.... Okumura K.	2003	CCL11
15	Polymorphic genes of xenobiotic-metabolizing enzymes associated with bronchial asthma in genetically predisposed children (12018173)	Vavilin V.A.... Gavalov S.M.	2002	CYP1A1, GSTT1, GSTM1
16	Acupuncture and bronchial asthma: a long-term randomized study of the effects of real versus sham acupuncture compared to controls in patients with bronchial asthma. (12614526)	Medici T.C.... WA1thrich B.	2002	RNASE3
17	Association of polymorphism of human beta 2-adrenergic receptor gene and bronchial asthma (12905693)	Gao J.M.... Liu Y.	2002	ADRB2, IGHE
18	Glutathione- S-transferase micro and theta gene polymorphisms as new risk factors of atopic bronchial asthma. (11862323)	Ivaschenko T.E.... Baranov V.S.	2002	GSTT1, GSTM1
19	Resistance to antibiotics and histamine production at the bacteria, isolated from the stomatopharynx of the children with bronchial asthma (16127900)	Voropaeva E.A.	2002	HDC
20	Selected parameters of the oxidative-antioxidative b alance in children with chronic severe bronchial asthma (11928662)	Postepski J.... Wawrzyszuk M.	2001	SOD1
21	Dysbioses of the oral cavity and intestines and immune reactivity in of adolescent bronchial asthma patients (11881503)	Gavrish T.V.	2001	IGHE
22	Genetic factors in predisposition to bronchial asthma (11234415)	Ivashchenko T.E.... Baranov V.S.	2001	GSTT1, GSTM1
23	Mechanisms of steroid osteoporosis development in patients with hormone-dependent bronchial asthma (11109624)	Emel'ianov A.V.... Amosov V.I.	2000	BGLAP
24	Analysis of the association between the T113M polymorphism of the human il-9 gene and bronchial asthma (10822820)	Freidin M.B.... Petrovskaia I.u.A.	2000	IL9
25	Imbalance production between interleukin-1beta (IL-1beta) and IL-1 receptor antagonist (IL-1Ra) in bronchial asthma. (11027520)	Mao X.Q.... Hopkin J.M.	2000	IL1B, IL1R1, IL1A
26	Anaphylactic reaction caused by histamine H2 receptor antagonists in a patient with bronchial asthma (10686827)	ArandjeloviA8 S.... PeriA8-PopadiA8 A.	1999	HRH2
27	Effects of ONO-1078 (pranlukast) on cytokine production in peripheral blood mononuclear cells of patients with bronchial asthma. (10520082)	Tohda Y.... Nakajima S.	1999	IL4, IL5
28	Suppression of airway inflammation by theophylline in adult bronchial asthma. (10202315)	Horiguchi T.... Imazu M.	1999	RNASE3
29	A study of granulocyte respiratory burst in patients with allergic bronchial asthma. (9484649)	Vargas L.... GarcA-a de Olarte D.	1998	CYCS
30	Lack of effect of salmon calcitonin on serum level of soluble form of E-selectin (CD 62E) in patients with atopic bronchial asthma. (10660976)	Polanowicz U.... Kondera-Arasz Z.	1998	SELE
31	Toxocariasis in a 5-year-old boy--manifesting as bronchial asthma and behavioral disorder (9629547)	Varga E.M.... Zach M.	1998	IGHE
32	Kimura's disease associated with bronchial asthma presenting eosinophilia and hyperimmunoglobulinemia E which were attenuated by suplatast tosilate (IPD-1151T). (9932643)	Tsukagoshi H.... Mori M.	1998	IL5, RNASE3
33	Cell biology of bronchial asthma: interesting new methods. Intracellular determination of cytokines in T-cells and basic proteins in eosinophilic granulocytes using flow cytometry (9221385)	Krug N.... Wagner T.O.	1997	TIMP1
34	An investigation of the clinical utility of serum interleukin-5 measurements in bronchial asthma patients (9493449)	Onizuka R.... Kumamoto K.	1997	IL5
35	The effect of heparin on release of histamine from b asophils under the influence of MCAF/MCP-I in patients with bronchial asthma (9489430)	Antczak-Marczak M.... Kuna P.	1997	TPT1
36	Increased plasma level of platelet-activating factor (PAF) and decreased serum PAF acetylhydrolase (PAFAH) activity in adults with bronchial asthma. (8833165)	Tsukioka K.... Nakagawa T.	1996	PAFAH1B1
37	Chemotactic serum activity for neutrophils and eosinophils and spontaneous production of histamine releasing factor in patients with seasonal bronchial asthma treated with nedocromil sodium (8754956)	Grzelewska-Rzymowska I.... Rozniecki J.	1996	TPT1
38	Elevation of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) levels in bronchial asthma. (7545095)	Koizumi A.... Horie T.	1995	TNF, SELE, VCAM1
39	Protection against bronchial asthma by CFTR delta F508 mutation: a heterozygote advantage in cystic fibrosis. (7585155)	Schroeder S.A.... Swift M.	1995	CFTR
40	Histamine releasing factors and chemotactic factors in evaluation of mucosal inflammation in bronchial asthma (7581067)	Kuna P.... Rozniecki J.	1995	TPT1
41	Production of selected cytokines by monocytes (IL-1 beta, IL-6) and lymphocytes (IL-2, IL-4) in peripheral blood of patients with n onallergic bronchial asthma treated with Broncho-Vaxom (8640150)	Moniuszko T.... Chyrek-Borowska S.	1995	IL1B, IL4
42	Eosinophil activity in bronchial asthma. (7926713)	Venge P.	1994	MPO, RNASE3
43	Regulation of beta 2-adrenergic receptors and the implications for bronchial asthma: an update. (8049696)	Pelaia G.... Marsico S.A.	1994	ADRB2
44	Levels of endothelin-1 in bronchoalveolar lavage fluid of patients with bronchial asthma (7800579)	Gawlik R.... Ziora D.	1994	EDN1
45	Role of histamine H1 receptor antagonists (antihistaminics) in therapy of bronchial asthma (1361983)	Wiebicke W.	1992	HRH1
46	Increased granulocyte/macrophage colony stimulating factor production by mononuclear cells from patients with bronchial asthma (1290409)	Kawaji K.... Ogura T.	1992	IL2
47	Neutrophil chemotactic activity of PAF, histamine and neuromediators in bronchial asthma. (1722427)	Rabier M.... Godard P.	1991	SST, VIP
48	The eosinophilic injury to the mucosa of the airways in the pathogenesis of bronchial asthma. (1953909)	Frigas E.... Gleich G.J.	1991	PRG2, EPX
49	The morphofunctional state of the thyroid in bronchial asthma patients (2368006)	Landyshev I.u.S.... Orlova E.V.	1990	SERPINA7
50	Effect of ketotifen on antigen-induced interleukin 2 (IL-2) responsiveness in lymphocytes from patients with atopic dermatitis and/or bronchial asthma. (2329018)	Noma T.... Maeda K.	1990	IL2

Genes related to bronchial asthma according to GeneCards:

(show top 50)    (show all 201)

id	Symbol	Description	Score	GeneCards Section Context
1	LTC4S	leukotriene C4 synthase	11.1	Publications, Summaries
2	ALOX15	arachidonate 15-lipoxygenase	11.1	Summaries
3	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	11.1	Summaries
4	ALOX5	arachidonate 5-lipoxygenase	11.1	Publications, Summaries
5	ALOX12	arachidonate 12-lipoxygenase	11.1	Summaries
6	IL13	interleukin 13	11.1	Publications, Aliases & Descriptions
7	CYSLTR2	cysteinyl leukotriene receptor 2	11.0	Summaries
8	CYSLTR1	cysteinyl leukotriene receptor 1	11.0	Summaries
9	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
10	SCGB3A2	secretoglobin, family 3A, member 2	11.0	Publications
11	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0	Publications
12	TPT1	tumor protein, translationally-controlled 1	11.0	Publications
13	EPX	eosinophil peroxidase	11.0	Publications
14	SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 4	11.0	Publications
15	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
16	ADAM33	ADAM metallopeptidase domain 33	11.0	Publications
17	IGES	immunoglobulin E concentration, serum	11.0	Publications
18	CD1A	CD1a molecule	11.0	Publications
19	NTF4	neurotrophin 4	11.0	Publications
20	C3AR1	complement component 3a receptor 1	11.0	Publications
21	TSLP	thymic stromal lymphopoietin	11.0	Publications
22	CMA1	chymase 1, mast cell	11.0	Publications
23	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
24	CYBA	cytochrome b-245, alpha polypeptide	11.0	Publications
25	CHIA	chitinase, acidic	11.0	Publications
26	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
27	HDC	histidine decarboxylase	11.0	Publications
28	IL9	interleukin 9	11.0	Publications
29	CPOX	coproporphyrinogen oxidase	11.0	Publications
30	HNMT	histamine N-methyltransferase	11.0	Publications
31	MS4A2	membrane-spanning 4-domains, subfamily A, member 2	11.0	Publications
32	IL4	interleukin 4	11.0	Publications
33	CHIT1	chitinase 1 (chitotriosidase)	11.0	Publications
34	NT5E	5'-nucleotidase, ecto (CD73)	11.0	Publications
35	CXCR2	chemokine (C-X-C motif) receptor 2	11.0	Publications
36	PON2	paraoxonase 2	11.0	Publications
37	POSTN	periostin, osteoblast specific factor	11.0	Publications
38	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
39	CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	11.0	Publications
40	PTGDR	prostaglandin D2 receptor (DP)	11.0	Publications
41	ELAC2	elaC homolog 2 (E. coli)	11.0	Publications
42	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	11.0	Publications
43	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
44	ADRB2	adrenoceptor beta 2, surface	11.0	Publications
45	UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	11.0	Publications
46	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
47	ICAM1	intercellular adhesion molecule 1	11.0	Publications
48	ATP2A3	ATPase, Ca++ transporting, ubiquitous	11.0	Publications
49	TBXA2R	thromboxane A2 receptor	11.0	Publications
50	PF4	platelet factor 4	11.0	Publications

Pathways related to bronchial asthma according to GeneDecks:

(show top 50)    (show all 139)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.6	CD80, IL12A, IL16, IL2, IL3, IL9
2	NFAT Signaling and Lymphocyte Interactions36	10.5	CD4, CD80, FCER2, IL12A, IL13, IL16
3	IL-6 Pathway36	10.5	CD80, IL10, IL12A, IL16, IL18, IL3
4	PGC1Alpha Pathway36	10.3	CD4, CD80, IL12A, IL13, IL16, IL18
5	Regulation of eIF4 and p70S6K36	10.3	CD4, CD80, ITGA2, ITGA4, ITGAM, ITGB2
6	PPAR Pathway36	10.2	KITLG, ITGA2, ITGA4, ITGAM, ITGB2, FLT1
7	Asthma20	10.2	MS4A2, IL10, IL13, IL3, IL4, IL5
8	Cell adhesion molecules (CAMs)20	10.2	SELL, SELP, CD28, CD86, CD4, CD80
9	Graft-versus-host disease20	10.0	CD28, CD86, CD80, IL1A, IL2, HLA-A
10	all-trans-Retinoic Acid Signaling in Brain36	9.9	CD80, IL10, IL12A, IL13, IL16, IL18
11	Endothelin-1 Signaling Pathway36	9.9	CD80, FLT1, IL10, IL12A, IL13, IL16
12	JNK Pathway36	9.8	KITLG, JUN, CD4, CD80, FLT1, IL1R1
13	MIF Mediated Glucocorticoid Regulation36	9.8	CD14, CD80, MIF, IL10, IL12A, IL13
14	Akt Signaling36	9.7	PDE3B, CD28, CD4, CD80, ITGA2, ITGAM
15	Malaria20	9.7	SELE, SELP, VCAM1, ITGB2, IL10, IL12A
16	Immune response MIF-mediated glucocorticoid regulation10	9.7	VCAM1, JUN, FOS, MIF, IL2, IL6
17	Immune response_MIF-mediated glucocorticoid regulation41	9.6	VCAM1, JUN, FOS, MIF, IL2, IL6
18	THC Differentiation Pathway36	9.6	CD28, CD86, IL10, IL12A, IL18, IL2
19	ERK Signaling36	9.6	KITLG, CD80, ITGA4, ITGAM, ITGB2, FLT1
20	Amoebiasis20	9.6	SERPINB4, CD14, ITGAM, ITGB2, IL12A, IL1B
21	STAT3 Pathway36	9.4	CD28, CD4, CD80, IL10, IL12A, IL13
22	PEDF Induced Signaling36	9.4	BDNF, CD80, FOS, IL10, IL12A, IL13
23	Tec Kinases Signaling36	9.4	KITLG, BDNF, CD28, CD4, CD80, ITGA2
24	MIF Regulation of Innate Immune Cells36	9.3	JUN, CD14, CD80, FOS, MIF, IL10
25	SOCS Pathway36	9.2	CD4, CD80, INS, IL10, IL12A, IL13
26	Hematopoietic cell lineage20	9.2	KITLG, CD14, CD4, CD1A, CD44, ITGA2
27	Pertussis20	9.2	JUN, CD14, ITGAM, ITGB2, FOS, IL10
28	Allograft rejection20	9.2	CD28, CD86, CD80, IL10, IL12A, IL2
29	Rho Family GTPases36	9.2	KITLG, BDNF, JUN, CD80, ITGA2, ITGA4
30	Molecular Mechanisms of Cancer36	9.1	KITLG, BDNF, JUN, CD4, CD80, ITGA2
31	Cytokine Network36	9.1	IL10, IL12A, IL13, IL16, IL18, IL1A
32	PAK Pathway36	9.1	KITLG, BDNF, CD80, FLT1, IL10, IL12A
33	Glucocorticoid Receptor Signaling36	9.1	JUN, CD4, CD80, FOS, IL10, IL12A
34	MAPK Family Pathway36	9.0	KITLG, BDNF, JUN, CD4, CD80, FLT1
35	Chagas disease (American trypanosomiasis)20	9.0	JUN, FOS, IL10, IL12A, IL1B, IL2
36	Intestinal immune network for IgA production20	8.9	CD28, CD86, CD80, ITGA4, IL10, IL2
37	TGF-Beta Pathway36	8.8	KITLG, BDNF, JUN, CD4, CD80, FOS
38	p38 Signaling36	8.8	KITLG, BDNF, CD28, CD4, CD80, FLT1
39	Autoimmune thyroid disease20	8.8	CD28, CD86, CD80, IL10, IL2, IL4
40	Leishmaniasis20	8.7	JUN, ITGA4, ITGAM, ITGB2, FOS, IL10
41	MAPK Signaling36	8.6	KITLG, BDNF, JUN, ITGA2, ITGA4, ITGAM
42	Antioxidant Action of Vitamin-C36	8.5	KITLG, BDNF, JUN, CD28, CD4, CD80
43	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.5	BGLAP, JUN, FOS, IL1A, IL1B, IL6
44	Type I diabetes mellitus20	8.5	CD28, CD86, CD80, INS, IL12A, IL1A
45	Influenza A20	8.3	JUN, IL12A, IL18, IL1A, IL1B, IL6
46	NFAT in Immune Response36	8.2	KITLG, BDNF, JUN, CD28, CD79A, CD86
47	JAK-STAT Pathway36	8.1	KITLG, BDNF, JUN, CD4, CD80, FOS
48	Cytokine-cytokine receptor interaction20	7.9	KITLG, VEGFA, LEP, FLT1, IL10, IL12A
49	Rheumatoid arthritis20	7.8	VEGFA, JUN, CD28, CD86, CD80, ITGB2
50	Tuberculosis20	7.7	CD14, ITGAM, ITGB2, IL10, IL12A, IL18

Compounds related to bronchial asthma according to GeneDecks:

(show top 50)    (show all 598)

id	Compound	Score	Top Affiliating Genes
1	glucose32	11.0	ATP2A3, ITGA2, MIF, NTF3, PDGFB, TAT
2	calcium32 9 18 9	13.6	PDE3B, KITLG, SFTPD, VIP, CMA1, CLCN3
3	mannose32	10.5	SFTPD, CHIT1, CEACAM3, CD79A, CD69, CD86
4	budesonide32 42 9 9	13.5	KITLG, SFTPD, BGLAP, CCL11, IGHE, PTGS1
5	l-nmma32	10.4	VIP, VCAM1, XDH, IL1RN, IGHE, CAT
6	phosphatidylcholine32	10.4	SFTPD, SELE, VIP, VCAM1, PAFAH1B1, CHRM3
7	n acetylcysteine32	10.3	SELE, SELP, VCAM1, BDNF, MUC5AC, CFTR
8	cuprophan32	10.2	SELL, SELP, VCAM1, CD14, ITGAM, ITGB2
9	quinacrine32 9 9	12.1	SELE, SELP, GSR, ALOX12, ALOX5, HNMT
10	h2o232	10.0	KITLG, SELL, VIP, BGLAP, BDNF, LEP
11	manganese superoxide32	10.0	VCAM1, CD14, GSR, GSTM1, GSTP1, GSTT1
12	latex32	10.0	KITLG, SCGB1A1, CHKB, CD14, CD44, ITGA2
13	citrate32	9.9	SELP, CHGA, CHKB, MT-CO2, CFTR, CD79A
14	warfarin32 34 9 18 9	13.8	SELP, NAT2, BGLAP, CD79A, ALB, HRH1
15	arachidonic acid32 9 18 9	12.8	KITLG, SELP, PAFAH1B1, BDNF, SCGB1A1, CD69
16	iron32 18	10.8	KITLG, SERPINA7, BDNF, SCGB1A1, CHIT1, XDH
17	12-o-tetradecanoylphorbol 13-acetate32	9.7	CD4, CD44, ITGA2, ITGAM, ITGB2, MMP14
18	glibenclamide32 34	10.6	VIP, LEP, CFTR, MIF, INS, ALOX12
19	propranolol32 34 9 18 9	13.5	VIP, CHGA, MPO, CCL5, CALCA, CYP1A1
20	polymyxin b32	9.5	SELE, VCAM1, CD14, ITGB2, IL10, IL1A
21	azathioprine32 34 9 9	12.4	BGLAP, CHKB, XDH, CD79A, CD44, GSTP1
22	erythromycin32 9 9	11.3	VIP, VCAM1, MPO, ITGB2, MMP9, IL13
23	okt332	9.3	SELE, VCAM1, CD79A, ITGB2, FCER2, IL10
24	theophylline32 9 18 9	12.2	PDE3B, SELL, SELP, CHGA, CHKB, XDH
25	etoposide32 42 9 9	12.2	SELE, PARP1, CHGA, JUN, CD44, GSTP1
26	tetracycline32 9 9	11.2	BGLAP, SCGB1A1, MMP14, MMP8, MMP9, MIF
27	mg 13232 42	10.2	PARP1, CFTR, JUN, IL1A, IL1B, IL8
28	valine32	9.1	VIP, BDNF, CFTR, MPO, GSTM1, GSTP1
29	betacarotene32	9.0	NAT2, LEP, CD79A, GSR, GSTM1, IL10
30	diphenyleneiodonium32	8.9	VEGFA, VCAM1, XDH, MPO, JUN, IL1B
31	il-1232	8.8	CD86, IL10, IL13, IL18, IL1B, IL1R1
32	pioglitazone32 9 9	10.7	VEGFA, VCAM1, LEP, JUN, MMP9, INS
33	cysteine32	8.7	SFTPD, SELP, SERPINB4, NAT2, CMA1, BGLAP
34	triptolide32	8.5	VEGFA, PARP1, JUN, CD86, CD14, IL1B
35	herbimycin a32 42	9.5	KITLG, SELE, SELL, VCAM1, JUN, CD28
36	alpha tocopherol32	8.5	VCAM1, BGLAP, LEP, CHKB, XDH, ITGAM
37	creatinine32	8.4	KITLG, SELE, SELL, SELP, SERPINA7, BDNF
38	atp32	8.3	PDE3B, PARP1, BDNF, CHGA, CHKB, CHRM3
39	glutamate32	8.2	VIP, LEP, CFTR, CD79A, CD4, ITGA2
40	rosiglitazone32 9 18 9	11.1	SELE, VCAM1, LEP, JUN, MMP9, INS
41	thymidine32 18	9.1	PDE3B, KITLG, SFTPD, VIP, BDNF, CHKB
42	thyroxine32 18	9.0	SERPINA7, VIP, BGLAP, LEP, CHKB, CEACAM3
43	pd 98,05932	7.7	KITLG, VCAM1, PARP1, BDNF, LEP, MUC5AC
44	clozapine32 34 9 9	10.6	BDNF, LEP, CHKB, CHRM3, MPO, FOS
45	zidovudine32 9 9	9.6	KITLG, MT-CO2, CD4, IL10, IL2, IL3
46	hydrocortisone32 9 9	9.6	KITLG, BGLAP, CD14, FLT1, MIF, INS
47	arsenite32 18	8.4	VEGFA, PARP1, JUN, MMP9, FOS, GSR
48	cholesterol32 9 18 9	10.4	PDE3B, KITLG, SFTPD, SELE, SELP, SERPINA7
49	methotrexate32 34 42 9 9	11.3	KITLG, SELE, NAT2, LEP, CHKB, MUC5AC
50	alanine32	7.3	KITLG, SELE, SELL, SERPINA7, VIP, VCAM1

Cellular components related to bronchial asthma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	9.6	FCER2, ITGA4, ITGA2, CD44, CD4, CD86
2	platelet alpha granule lumen	GO:031093	9.2	KNG1, TGFB1, TIMP1, PDGFB, PF4, PPBP
3	secretory granule	GO:030141	9.1	TF, ELANE, CYBA, IL1B, INS, MPO
4	integral to plasma membrane	GO:005887	9.0	TNF, HLA-DRB1, HLA-DQA1, HLA-B, HLA-A, HRH2
5	cell surface	GO:009986	8.3	HSPA8, TNF, TNFRSF1A, CYP3A4, PDGFB, ABCB1
6	plasma membrane	GO:005886	7.7	PTGDR, PTGER4, PTGS1, TBXA2R, CYSLTR2, CYSLTR1
7	extracellular region	GO:005576	6.5	KITLG, IL6, IL5, IL4R, IL3, IL2
8	extracellular space	GO:005615	6.4	CD14, ICAM1, IFNG, CCL5, CCR3, CCL11

Biological processes related to bronchial asthma according to GeneDecks:

(show all 40)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemotaxis	GO:006935	10.8	C3AR1, C5AR1, C5, CXCR2, PPBP, CYSLTR1
2	positive regulation of vasoconstriction	GO:045907	10.8	CYSLTR1, TBXA2R, PTGS1, HRH1, ALOX5, F2R
3	positive regulation of smooth muscle contraction	GO:045987	10.7	ADA, EDN1, SRF, TBXA2R, PTGS1, F2R
4	leukocyte cell-cell adhesion	GO:007159	10.6	CALCA, ICAM1, CCL5, ITGB2, ITGA4, VCAM1
5	elevation of cytosolic calcium ion concentration	GO:007204	10.5	EDN1, AGTR1, TAC1, KNG1, C5AR1, C3AR1
6	cell surface receptor signaling pathway	GO:007166	10.5	TNFRSF10B, SST, EDN1, CXCR2, C5, ADRB2
7	xenobiotic metabolic process	GO:006805	10.4	CYP1B1, CYP3A4, CYP2E1, CYP2D6, CYP4F3, EPHX2
8	cellular response to lipopolysaccharide	GO:071222	10.4	LTC4S, NOS2, TNFRSF1B, ICAM1, IFNG, CCR5
9	positive regulation of interleukin-2 biosynthetic process	GO:045086	10.3	IL1B, IL1A, CD80, CD4, CD86, CD28
10	response to lipopolysaccharide	GO:032496	10.1	PTGER4, TBXA2R, NGF, EDN1, ELANE, TAC1
11	positive regulation of T cell proliferation	GO:042102	10.1	CD28, IL12A, IL1B, IL4, IL6, CCL5
12	positive regulation of angiogenesis	GO:045766	10.1	C3AR1, C3, C5, TBXA2R, TNFRSF1A, CCL5
13	monocyte chemotaxis	GO:002548	10.1	PDGFB, CALCA, CCL5, IL6R, IL6, FLT1
14	regulation of blood pressure	GO:008217	10.1	EPHX2, C3AR1, SOD1, TAC1, ACE, PTGS1
15	positive regulation of smooth muscle cell proliferation	GO:048661	10.0	ELANE, EDN1, PDGFB, TNF, CCL5, IL6R
16	G-protein coupled receptor signaling pathway	GO:007186	9.9	TBXA2R, SST, EDN1, AGTR1, C5, C3
17	aging	GO:007568	9.8	ADA, TGFB1, TIMP1, NR3C1, PTGS1, CALCA
18	response to radiation	GO:009314	9.8	JUN, MMP9, IL18, CCL11, NR3C1, NGF
19	anti-apoptosis	GO:006916	9.8	ALOX12, TPT1, TNF, NR3C1, NGF, SOD1
20	positive regulation of cytokine secretion	GO:050715	9.8	PTGER4, TNF, IL1A, IL10, INS, MIF
21	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.7	PDGFB, SELP, FLT1, INS, ANGPT1, CCL5
22	immune response	GO:006955	9.7	IL18, IKBKAP, IGHE, HRH2, HLA-A, HLA-B
23	positive regulation of gene expression	GO:010628	9.7	TGFB1, CSF1, CSF2, EPHX2, PF4, NGF
24	cell-cell signaling	GO:007267	9.7	CCR5, CCL5, CALCA, TNFSF10, SST, NTF3
25	positive regulation of MAP kinase activity	GO:043406	9.6	TGFB1, ELANE, EDN1, PDGFB, TNF, HTR2A
26	response to glucocorticoid stimulus	GO:051384	9.6	TAT, NGF, TNF, HNMT, CCL5, IL6
27	positive regulation of nitric oxide biosynthetic process	GO:045429	9.6	HRH1, TNF, EDN1, ICAM1, IFNG, INS
28	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	IL5, IL6, IL6R, ANGPT1, PDGFB, IL3
29	platelet degranulation	GO:002576	9.5	KNG1, SOD1, TF, TGFB1, TIMP1, PDGFB
30	positive regulation of cell migration	GO:030335	9.5	COL1A1, PDGFB, EDN1, TGFB1, CSF1, F2R
31	blood coagulation	GO:007596	9.4	PPBP, NOS2, COL1A1, PF4, PDGFB, HBG2
32	interferon-gamma-mediated signaling pathway	GO:060333	9.2	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A, ICAM1
33	positive regulation of mitosis	GO:045840	9.2	CD28, INS, IL1A, IL1B, TNF, PDGFB
34	platelet activation	GO:030168	9.2	PF4, PDGFB, TIMP1, TGFB1, TF, SOD1
35	inflammatory response	GO:006954	9.2	SELE, IL8, IL9, CCL11, CCR5, CCR3
36	cytokine-mediated signaling pathway	GO:019221	9.0	HLA-A, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNFRSF1A
37	response to drug	GO:042493	9.0	PDGFB, NGF, SST, TBXA2R, LTC4S, EDN1
38	response to hypoxia	GO:001666	8.5	ANGPT1, CAT, TNF, TNFRSF1A, SRF, CRP
39	positive regulation of cell proliferation	GO:008284	8.2	EDN1, PDGFB, NGF, ALOX12, TIMP1, TGFB1
40	negative regulation of apoptotic process	GO:043066	8.1	ALB, CASP3, CAT, TNF, PF4, TIMP1

Molecular functions related to bronchial asthma according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	receptor binding	GO:005102	9.6	TNFSF10, NTF3, CRH, NOS2, KNG1, C5
2	heme binding	GO:020037	9.4	CYBA, CYCS, CYP4F3, NOS2, HBG2, EPX
3	iron ion binding	GO:005506	9.3	CYP2E1, CYP2D6, CYCS, CYP4F3, NOS2, HBG2
4	cytokine activity	GO:005125	9.1	CSF2, CSF1, IL1A, IL18, IL16, IL13
5	protein homodimerization activity	GO:042803	9.1	TAP1, TGFB1, G6PD, PDGFB, NOS2, OXA1L
6	growth factor activity	GO:008083	8.5	CSF2, IL3, IL2, IL1B, IL12A, IL10
7	protein binding	GO:005515	5.4	TNFRSF1A, TNFRSF1B, TNFSF10, PTGDR, PTGER4, TBXA2R