Aliases & Classifications for Bronchiectasis

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Sources:
61UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek, 22GTR, 56SNOMED-CT, 39NCIt, 27ICD9CM, 33MeSH, 25ICD10
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Aliases & Descriptions for Bronchiectasis:

Name: Bronchiectasis 8 10 44 22 61
Polynesian Bronchiectasis 8
 
Kartagener Syndrome 61


Classifications:



External Ids:

Disease Ontology8 DOID:9563
NCIt39 C84475
ICD9CM27 494
MeSH33 D001987
ICD1025 J47

Summaries for Bronchiectasis

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Disease Ontology:8 A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

MalaCards based summary: Bronchiectasis, also known as polynesian bronchiectasis, is related to cystic fibrosis and aspergillosis. An important gene associated with Bronchiectasis is DNAI1 (dynein, axonemal, intermediate chain 1), and among its related pathways are Sodium channels and transporters inward current and Aldosterone-regulated sodium reabsorption. The drug acetylcysteine and the compounds trypsinogen and dermatan sulfate have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and testes, and related mouse phenotypes are respiratory system and immune system.

Wikipedia:64 Bronchiectasis is a disease in which there is permanent enlargement of parts of the airways of the lung.... more...

Related Diseases for Bronchiectasis

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Diseases related to Bronchiectasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1cystic fibrosis30.8CFTR, BPI, CTSG, ELANE
2aspergillosis30.8ELANE
3ciliary dyskinesia, primary, 1, with or without situs inversus30.6DNAI1, CFTR
4bronchitis30.6ELANE, CFTR
5cholangitis30.5CFTR
6respiratory failure30.1ELANE, CFTR
7asthma30.1ELANE, MMP8, CTSG
8aneurysm29.9MMP8, ELANE
9ulcerative colitis29.9BPI, CTSG
10vasculitis29.8CTSG, ELANE, BPI
11acute respiratory distress syndrome29.8ELANE, CTSG
12pneumonia29.7ELANE, MMP8, BPI, CFTR, CTSG
13pulmonary emphysema29.5MMP8, ELANE, CTSG
14rheumatoid arthritis29.4CTSG, BPI, MMP8, CFTR, ELANE
15idiopathic bronchiectasis10.5
16primary ciliary dyskinesia10.3
17pseudohypoaldosteronism, type i10.3SCNN1A, SCNN1B
18emphysema due to aat deficiency10.3ELANE
19bronchiectasis with or without elevated sweat chloride 210.3
20sinusitis10.3
21dextrocardia10.3
22allergic bronchopulmonary aspergillosis10.3
23tuberculosis10.3
24pulmonary function10.2
25bronchiectasis with or without elevated sweat chloride 110.2
26bronchiectasis with or without elevated sweat chloride 310.2
27common variable immunodeficiency10.2
28yellow nail syndrome10.2
29gastroesophageal reflux10.2
30ciliary dyskinesia-bronchiectasis10.2
31periodontal disease10.2ELANE
32reactive arthritis10.2BPI, MMP8
33arthritis10.2
34influenza10.2
35liddle syndrome10.2SCNN1G, SCNN1B, SCNN1A
36hypertension, essential10.1SCNN1A, SCNN1G, SCNN1B
37alcoholic pancreatitis10.1CFTR, ELANE
38steatorrhea10.1CFTR, ELANE
39exocrine pancreatic insufficiency10.1ELANE, CFTR
40pancreas disease10.1CFTR, ELANE
41keratoconus10.1CTSG, MMP8
42situs inversus10.1
43agammaglobulinemia10.1
44amyloidosis10.1
45aspiration pneumonia10.1
46esophagitis10.1
47obstructive lung disease10.1
48thyroiditis10.1
49bronchiectasis oligospermia10.1
50haemophilus influenzae10.1

Graphical network of the top 20 diseases related to Bronchiectasis:



Diseases related to bronchiectasis

Symptoms for Bronchiectasis

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Drugs & Therapeutics for Bronchiectasis

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Drug clinical trials:

Search ClinicalTrials for Bronchiectasis

Search NIH Clinical Center for Bronchiectasis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Bronchiectasis

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Genetic tests related to Bronchiectasis:

id Genetic test Affiliating Genes
1 Bronchiectasis22

Anatomical Context for Bronchiectasis

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MalaCards organs/tissues related to Bronchiectasis:

31
Lung, Neutrophil, Testes, Colon, Thyroid, Bone, Kidney, Bone marrow, Lymph node, Brain, Smooth muscle, Breast, Myeloid, Monocytes, T cells, B cells

Animal Models for Bronchiectasis or affiliated genes

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MGI Mouse Phenotypes related to Bronchiectasis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5CFTR, SCNN1B, SCNN1A, SCNN1G, DNAI1
2MP:00053877.9CTSG, DNAI1, ELANE, MMP8, CFTR
3MP:00028737.5CTSG, ELANE, SCNN1G, SCNN1A, SCNN1B, CFTR
4MP:00107687.2CFTR, SCNN1B, SCNN1A, SCNN1G, ELANE, CTSG

Publications for Bronchiectasis

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Articles related to Bronchiectasis:

(show top 50)    (show all 661)
idTitleAuthorsYear
1
A rare cause of bronchiectasis. (25849059)
2015
2
Bronchiectasis: A retrospective study of clinical and aetiological investigation in a general respiratory department. (25854129)
2015
3
Impact of Different Etiologies of Bronchiectasis on the Pulmonary Function Tests. (25380609)
2014
4
The prevalence of bronchiectasis in patients with Marfan syndrome. (25199019)
2014
5
Expression of soluble triggering receptor expressed on myeloid cells-1 in childhood CF and Non-CF bronchiectasis. (25348906)
2014
6
Quality of Life Questionnaire-Bronchiectasis: final psychometric analyses and determination of minimal important difference scores. (25323621)
2014
7
Epicardially originating ventricular tachycardia: an unusual presentation of bronchiectasis. (23365070)
2013
8
Validation of a Quality of Life Questionnaire for Bronchiectasis: psychometric analyses of the Spanish QOL-B-V3.0. (24142190)
2013
9
Molecular epidemiological analysis suggests cross infection with Pseudomonas aeruginosa is rare in Non-Cystic Fibrosis bronchiectasis. (24176999)
2013
10
Depression and anxiety symptoms in bronchiectasis: associations with health-related quality of life. (22544417)
2013
11
Surgical treatment of bronchiectasis: a retrospective observational study of 138 patients. (23825752)
2013
12
Lung transplantation for cystic fibrosis and bronchiectasis. (23821505)
2013
13
Indigenous children from three countries with non-cystic fibrosis chronic suppurative lung disease/bronchiectasis. (23401398)
2013
14
Mannose-binding lectin and innate immunity in bronchiectasis. (24429113)
2013
15
Bronchiectasis exacerbation study on azithromycin and amoxycillin-clavulanate for respiratory exacerbations in children (BEST-2): study protocol for a randomized controlled trial. (23421781)
2013
16
Microbes in bronchiectasis: the forest or the trees? (23675713)
2013
17
Quantitative and qualitative computed tomographic characteristics of bronchiectasis in 12 dogs. (23578226)
2013
18
Pulmonary rehabilitation for patients with bronchiectasis: case reports. (22510678)
2012
19
Focal bronchiectasis causing abnormal pulmonary radioiodine uptake in a patient with well-differentiated papillary thyroid carcinoma. (23097725)
2012
20
Bronchiectasis in chronic pulmonary aspiration: risk factors and clinical implications. (22028069)
2012
21
Pathogenesis of bronchiectasis. (22640841)
2012
22
Immune regulation in idiopathic bronchiectasis. (23231716)
2012
23
Inhaled gentamicin in non-cystic fibrosis bronchiectasis: effects of long-term therapy. (21470074)
2011
24
Risk of infections in bronchiectasis during disease-modifying treatment and biologics for rheumatic diseases. (22046967)
2011
25
Infection and remodelling: a 21st century model of bronchiectasis? (21965500)
2011
26
Lady Windermere revisited: treatment with thoracoscopic lobectomy/segmentectomy for right middle lobe and lingular bronchiectasis associated with non-tuberculous mycobacterial disease. (21324708)
2011
27
Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century. (20709772)
2010
28
Pneumatosis intestinalis presenting with a pneumoperitoneum in a patient with chronic bronchiectasis: a delayed diagnosis of superior mesenteric artery ischaemia. (22767661)
2010
29
British Thoracic Society guideline for non-CF bronchiectasis. (20627912)
2010
30
Cardiac herniation following completion pneumonectomy for bronchiectasis. (20826968)
2010
31
Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand. (20854242)
2010
32
A decade of non-cystic fibrosis bronchiectasis 1996-2006. (20666070)
2010
33
Respiratory bacterial pathogens in the nasopharynx and lower airways of Australian indigenous children with bronchiectasis. (20656297)
2010
34
Stable bronchiectasis is associated with low serum L-ficolin concentrations. (20298369)
2009
35
Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening. (19616787)
2009
36
Exhaled breath condensate MMP-9 levels in children with bronchiectasis. (19725099)
2009
37
Bronchiectasis: pathophysiology, presentation and management. (18837280)
2008
38
Congenital lymphoedema, bronchiectasis and seizure: case report. (18663889)
2008
39
Bronchiectasis, part 2: Management. (20046814)
2008
40
Bronchiectasis in adults: a review. (18824830)
2008
41
Upregulation of ICAM-1 expression in bronchial epithelial cells by airway secretions in bronchiectasis. (17931847)
2008
42
Re: A retrospective study of the relationship between tracheal collapse and bronchiectasis in dogs. (18018738)
2007
43
IFN gamma and CXCR-1 gene polymorphisms in idiopathic bronchiectasis. (17026468)
2006
44
Bronchiectasis worsening by p-ANCA (bactericidal/permeability-increasing protein) positive vasculitis. A case report and review of the literature]. (16610259)
2005
45
Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis. (14985560)
2004
46
CFTR gene mutations in adults with disseminated bronchiectasis. (9272738)
1997
47
Bronchiectasis and homozygous (P1ZZ) alpha 1-antitrypsin deficiency. (8711667)
1996
48
Sputum sol phase proteins and elastase activity in patients with clinically stable bronchiectasis. (1372451)
1992
49
Simulated dextrocardia associated with bronchiectasis; report of case. (20280493)
1946
50
Dextrocardia and bronchiectasis, a review of the literature and a report of two cases. (20996259)
1946

Variations for Bronchiectasis

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Clinvar genetic disease variations for Bronchiectasis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1DNAI1NM_001184940.1(FAM219A): c.-792dupduplicationPathogenicrs397515363GRCh37Chr 9, 34459053: 34459053
2DNAI1NM_012144.3(DNAI1): c.1543G> A (p.Gly515Ser)single nucleotide variantPathogenicrs79833450GRCh37Chr 9, 34513163: 34513163
3DNAI1NM_012144.3(DNAI1): c.1490G> A (p.Gly497Asp)single nucleotide variantPathogenicrs376252276GRCh37Chr 9, 34513110: 34513110
4DNAI1NM_012144.3(DNAI1): c.2001+1G> Asingle nucleotide variantPathogenicrs397515563GRCh37Chr 9, 34517466: 34517466

Expression for genes affiliated with Bronchiectasis

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Search GEO for disease gene expression data for Bronchiectasis.

Pathways for genes affiliated with Bronchiectasis

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Pathways related to Bronchiectasis according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2SCNN1G, SCNN1A, SCNN1B
2
Show member pathways
9.2SCNN1G, SCNN1A, SCNN1B
3
Show member pathways
9.2SCNN1G, SCNN1A, SCNN1B
49.2SCNN1G, SCNN1A, SCNN1B
5
Show member pathways
9.2SCNN1B, SCNN1A, SCNN1G
6
Show member pathways
8.9CFTR, SCNN1B, SCNN1A, SCNN1G
7
Show member pathways
8.9CFTR, SCNN1B, SCNN1A, SCNN1G
88.9CFTR, SCNN1B, SCNN1A, SCNN1G
98.9SCNN1G, SCNN1A, SCNN1B, CFTR
10
Show member pathways
8.6MMP8, ELANE, CTSG
11
Show member pathways
8.6CTSG, ELANE, MMP8

Compounds for genes affiliated with Bronchiectasis

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Compounds related to Bronchiectasis according to GeneCards Suite gene sharing:

(show all 43)
idCompoundScoreTop Affiliating Genes
1trypsinogen4410.0CFTR, ELANE
2dermatan sulfate449.8CFTR, ELANE
3batimastat44 60 1111.7MMP8, ELANE
4salicylic acid44 2810.7DNAI1, CFTR
5triamterene44 24 1111.7SCNN1B, SCNN1A, SCNN1G
6polysulfone449.7BPI, ELANE
74-nitroanilide449.5CTSG, ELANE
8elastatinal449.5CTSG, ELANE
9saccharin44 110.5ELANE, CTSG
10thermolysin449.5ELANE, CTSG
11chymostatin449.5ELANE, CTSG
12pmsf449.5CTSG, ELANE
13doxycycline44 1110.5ELANE, MMP8
14epsilon aminocaproic acid449.5CTSG, ELANE
15phosphonate449.5CTSG, MMP8
16diisopropylfluorophosphate449.4CTSG, ELANE
17phosphoramidon44 1110.4ELANE, CTSG
18cytochalasin b449.4CTSG, ELANE
19actinomycin d449.4SCNN1A, CFTR, BPI
20n-formylmethionyl-leucylphenylalanine449.3ELANE, CTSG
21amiloride44 28 1111.3SCNN1G, SCNN1A, SCNN1B, CFTR
22cyclosporin a44 28 6011.3CFTR, ELANE, MMP8
23xanthine44 2410.3CTSG, MMP8
24pge2449.3CFTR, MMP8, ELANE
25kininogen449.2CTSG, ELANE
26aspirin44 50 28 2412.1ELANE, CTSG, CFTR
27aprotinin44 1110.1ELANE, CTSG
28epinephrine44 24 1111.1CFTR, CTSG, ELANE
29(4-aminophenyl)mercuric acetate449.0CTSG, ELANE, MMP8
30hocl449.0MMP8, ELANE, CTSG
31urea44 24 1110.9CTSG, BPI, MMP8
32fibrinogen448.9ELANE, CTSG, MMP8
33endotoxin448.9BPI, CTSG, ELANE
34fmlp448.9CTSG, BPI, ELANE
35h2o2448.7MMP8, CTSG, CFTR, ELANE
36superoxide44 249.6MMP8, ELANE, CTSG
37alanine448.5CFTR, BPI, MMP8, CTSG
38sodium44 249.5SCNN1B, CTSG, SCNN1G, SCNN1A, CFTR
39lactate448.4BPI, ELANE, CTSG, MMP8
40heparin44 28 24 1111.2CTSG, ELANE, BPI
41retinoic acid44 249.1ELANE, BPI, CTSG, MMP8, CFTR
42serine448.0CTSG, CFTR, MMP8, ELANE, BPI
43cysteine447.6ELANE, MMP8, BPI, CFTR, CTSG, SCNN1G

GO Terms for genes affiliated with Bronchiectasis

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Cellular components related to Bronchiectasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sodium channel complexGO:00347069.4SCNN1G, SCNN1A, SCNN1B
2external side of plasma membraneGO:00098979.2SCNN1G, SCNN1A, SCNN1B
3secretory granuleGO:00301419.1CTSG, ELANE
4apical plasma membraneGO:00163249.0CFTR, SCNN1B, SCNN1A, SCNN1G
5integral component of plasma membraneGO:00058878.5SCNN1B, SCNN1A, SCNN1G, BPI
6cell surfaceGO:00099868.5CTSG, ELANE, CFTR
7extracellular vesicular exosomeGO:00700627.3SCNN1B, SCNN1A, SCNN1G, ELANE, BPI, CTSG

Biological processes related to Bronchiectasis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal water homeostasisGO:00508919.5SCNN1G, SCNN1A, SCNN1B
2sodium ion homeostasisGO:00550789.5SCNN1B, SCNN1A, SCNN1G
3sensory perception of tasteGO:00509099.5SCNN1G, SCNN1A, SCNN1B
4excretionGO:00075889.5SCNN1B, SCNN1A, SCNN1G
5response to stimulusGO:00508969.5SCNN1G, SCNN1A, SCNN1B
6sodium ion transportGO:00068149.5SCNN1B, SCNN1A, SCNN1G
7sodium ion transmembrane transportGO:00357259.4SCNN1G, SCNN1A, SCNN1B
8collagen catabolic processGO:00305749.4ELANE, MMP8
9positive regulation of immune responseGO:00507789.3ELANE, CTSG
10ion transmembrane transportGO:00342209.2SCNN1B, SCNN1A, SCNN1G
11negative regulation of growth of symbiont in hostGO:00441309.2CTSG, ELANE
12transmembrane transportGO:00550859.0CFTR, SCNN1B, SCNN1A, SCNN1G
13extracellular matrix disassemblyGO:00226178.8CTSG, ELANE, MMP8
14proteolysisGO:00065088.5CTSG, ELANE, MMP8
15extracellular matrix organizationGO:00301988.3CTSG, ELANE, MMP8

Molecular functions related to Bronchiectasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ligand-gated sodium channel activityGO:00152809.2SCNN1G, SCNN1A, SCNN1B
2WW domain bindingGO:00506999.1SCNN1B, SCNN1A, SCNN1G
3peptidase activityGO:00082339.1CTSG, ELANE
4serine-type endopeptidase activityGO:00042528.3CTSG, ELANE, MMP8

Sources for Bronchiectasis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet