MCID: BRN022
MIFTS: 62

Bronchiectasis malady

Summaries for Bronchiectasis

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

MalaCards: Bronchiectasis, also known as polynesian bronchiectasis, is related to cystic fibrosis and asthma. An important gene associated with Bronchiectasis is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)), and among its related pathways are Class C/3 (Metabotropic glutamate/pheromone receptors) and Aldosterone-regulated sodium reabsorption. The drug acetylcysteine and the compounds h2o2 and hocl have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and lymph node, and related mouse phenotypes are homeostasis/metabolism and immune system.

Wikipedia:64 Bronchiectasis is a disease state defined by localized, irreversible dilation of part of the bronchial... more...

Description from OMIM:47 211400

Aliases & Classifications for Bronchiectasis

Sources:
8Disease Ontology, 22GTR, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 47OMIM, 35MeSH, 27ICD9CM, 40NCIt
See all sources

Aliases & Descriptions:

bronchiectasis 8 22 10 45 61
polynesian bronchiectasis 8


External Ids:

Disease Ontology8 DOID:9563
OMIM47 211400
MeSH35 D001987
ICD9CM27 494
NCIt40 C84475

Related Diseases for Bronchiectasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Bronchiectasis family:

bronchiectasis with or without elevated sweat chloride 2 bronchiectasis with or without elevated sweat chloride 1, modifier of
bronchiectasis with or without elevated sweat chloride 1 bronchiectasis with or without elevated sweat chloride 3

Diseases related to Bronchiectasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 242)
idRelated DiseaseScoreTop Affiliating Genes
1cystic fibrosis31.3ELANE, SERPINA3, SERPINA1, SLPI, CFTR, IL8
2asthma30.7IGHE, RNASE3
3pulmonary disease, chronic obstructive30.5SERPINA1
4aspergillosis30.4TLR2, MBL2, SLPI, ELANE
5bronchitis30.4SERPINA1, RNASE3
6sinusitis30.4IGHE, RNASE3, CFTR
7allergic bronchopulmonary aspergillosis30.4CFTR, IGHE, MBL2
8tuberculosis30.4SERPINA1, CTSG, MBL2, TLR2, BPI
9arthritis30.1CTSG, IL8, SERPINA1
10vasculitis30.1BPI, MBL2, CTSG, MPO, SERPINA1, ELANE
11bronchiectasis with or without elevated sweat chloride 130.0SCNN1B
12bronchiolitis obliterans29.8MMP8, IL8
13bronchiolitis29.8IGHE, RNASE3, IL8
14bronchopulmonary dysplasia29.8RNASE3, IL8, ELANE
15allergic asthma29.8TLR2, IGHE, RNASE3, IL8
16ulcerative colitis29.8BPI, TLR2, CTSG, MPO, RNASE3, IL8
17intrinsic asthma29.8IGHE, RNASE3
18ciliary dyskinesia-bronchiectasis10.4
19primary ciliary dyskinesia10.3
20n syndrome10.3
21dextrocardia10.3
22yellow nail syndrome10.2
23common variable immunodeficiency10.2
24pulmonary function10.2
25bronchiectasis oligospermia10.2
26bronchiectasis with or without elevated sweat chloride 210.2
27bronchiectasis with or without elevated sweat chloride 1, modifier of10.2
28situs inversus10.1
29agammaglobulinemia10.1
30amyloidosis10.1
31aspiration pneumonia10.1
32kartagener syndrome10.1
33crescentic glomerulonephritis10.0
34polycystic kidney disease10.0
35oligospermia10.0
36sleep disorder10.0
37young syndrome10.0
38mounier-kuhn syndrome10.0
39diffuse panbronchiolitis10.0
40amyloidosis, secondary10.0
41amyloidosis, renal10.0
42bronchiectasis with or without elevated sweat chloride 310.0
43rheumatic disease10.0
44cholangitis10.0CFTR
45coronary heart disease10.0MMP8
46diabetes mellitus10.0SERPINA1
47myocardial infarction10.0SERPINA3
48common variable immune deficiency10.0MBL2
49cholera10.0CFTR
50sarcoidosis10.0TAP2, SERPINA3

Graphical network of the top 20 diseases related to Bronchiectasis:



Diseases related to bronchiectasis

Clinical Features for Bronchiectasis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

211400

Drugs & Therapeutics for Bronchiectasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bronchiectasis

Drug clinical trials:

Search ClinicalTrials for Bronchiectasis

Search NIH Clinical Center for Bronchiectasis

Search CenterWatch for Bronchiectasis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Bronchiectasis

Sources:
22GTR
See all sources

Genetic tests related to Bronchiectasis:

id Genetic test Affiliating Genes
1 Bronchiectasis22

Anatomical Context for Bronchiectasis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Bronchiectasis:

33
Brain, Kidney, Lymph node, Lung, Bone marrow, Smooth muscle, Colon, Thyroid, Breast, Monocytes, T cells, B cells

Animal Models for Bronchiectasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Bronchiectasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.2MBL2, SCNN1B, SCNN1A, SCNN1G, MPO, IGHE
2MP:000538710.0ELANE, TLR2, MBL2, CTSG, MPO, IGHE
3MP:00053979.9MPO, CTSG, MBL2, TLR2, IGHE, IL8

Publications for Bronchiectasis

Sources:
51PubMed
See all sources

Articles related to Bronchiectasis:

(show top 50)    (show all 610)
idTitleAuthorsYear
1
Is it asthma, is it bronchiectasisa8 (21497005)
or is it an
2
Indigenous children from three countries with non-cystic fibrosis chronic suppurative lung disease/bronchiectasis. (23401398)
2013
3
Incremental shuttle walking test: a reproducible and valid test to evaluate exercise tolerance in adults with non-cystic fibrosis bronchiectasis. (24361325)
2013
4
Bronchiectasis: breaking the cycle of inflammation and infection. (24321816)
2013
5
Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease. (23392438)
2013
6
Primary achalasia with pneumoesophagus and bronchopleural fistula causing right lung collapse and bronchiectasis. (23798088)
2013
7
Type I Arnold-Chiari malformation with bronchiectasis, respiratory failure, and sleep disordered breathing: a case report. (23433005)
2013
8
Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition. (23564400)
2013
9
Risk factors for bronchiectasis in children with cystic fibrosis. (23692169)
2013
10
Phase 3 randomized study of the efficacy and safety of inhaled dry powder mannitol for the symptomatic treatment of non-cystic fibrosis bronchiectasis. (23429964)
2013
11
Pulmonary rehabilitation for patients with bronchiectasis: case reports. (22510678)
2012
12
Imaging of bronchiectasis. (22640843)
2012
13
Airway clearance in bronchiectasis: breaking the infection-inflammation cycle. (22246705)
2012
14
Recurrent polymyositis triggered by bronchiectasis-associated infections. (23083042)
2012
15
A 46-year-old man with tracheomegaly, tracheal diverticulosis, and bronchiectasis: Mounier-Kuhn syndrome. (22628937)
2012
16
Impact of recent antibiotics on nasopharyngeal carriage and lower airway infection in Indigenous Australian children with non-cystic fibrosis bronchiectasis. (22819151)
2012
17
Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis. (23117981)
2012
18
Bronchiectasis is associated with human T-lymphotropic virus 1 infection in an Indigenous Australian population. (22095566)
2012
19
Bronchiectasis: why the diagnosis shouldn't be missed in primary care. (21597661)
2011
20
Surgery for bronchiectasis: The effect of morphological types to prognosis. (21264168)
2011
21
Sodium cromoglycate and eformoterol attenuate sensitivity and reactivity to inhaled mannitol in subjects with bronchiectasis. (21054671)
2011
22
Bronchiectasis: do we need aetiological investigation? (21251482)
2011
23
Bronchiectasis and pulmonary exacerbations in children and young adults with cystic fibrosis. (21148242)
2011
24
A long-term study assessing the factors influencing survival and morbidity in the surgical management of bronchiectasis. (22152759)
2011
25
Singing for children and adults with bronchiectasis. (20166097)
2010
26
Diffuse cylindrical bronchiectasis due to eosinophilic bronchopneumopathy in a dog. (20885829)
2010
27
Stable bronchiectasis is associated with low serum L-ficolin concentrations. (20298369)
2009
28
Exhaled breath condensate MMP-9 levels in children with bronchiectasis. (19725099)
2009
29
Bronchial and peripheral airway nitric oxide in primary ciliary dyskinesia and bronchiectasis. (19117740)
2009
30
A neglected problem of developing countries: Noncystic fibrosis bronchiectasis. (19561918)
2009
31
Assessing response to treatment of exacerbations of bronchiectasis in adults. (18829674)
2009
32
Clinical determinants of the 6-Minute Walk Test in bronchiectasis. (19070473)
2009
33
Airway clearance physiotherapy improves quality of life in people with bronchiectasis. (19929774)
2009
34
Bronchiectasis, a long-term sequela of ammonia inhalation: a case report and review of the literature. (18538935)
2009
35
Regulation of immunity in bronchiectasis. (18608925)
2009
36
Bronchiectasis--a complex multifactorial disease. (20298394)
2009
37
Bronchiectasis, part 2: Management. (20046814)
2008
38
Bronchiectasis in adults. Introduction. (18638619)
2008
39
Physical and transport properties of sputum from children with idiopathic bronchiectasis. (18753467)
2008
40
Nursing patients with bronchiectasis: part one. (18605349)
2008
41
Right and left ventricular function and pulmonary artery pressure in patients with bronchiectasis. (18071019)
2008
42
Anxiety related to genetic testing for alpha-1 antitrypsin deficiency and cystic fibrosis in COPD and/or bronchiectasis patients. (18376109)
2008
43
Helicobacter pylori in bronchiectasis: a polymerase chain reaction assay in bronchoalveolar lavage fluid and bronchiectatic lung tissue. (17350482)
2007
44
Treatment of bronchiectasis in adults. (18033931)
2007
45
Bronchiectasis worsening by p-ANCA (bactericidal/permeability-increasing protein) positive vasculitis. A case report and review of the literature]. (16610259)
2005
46
Clinical bronchiectasis complicating pulmonary sarcoidosis: case series of seven patients. (12102612)
2002
47
Antioxidant effect of beta-carotene in cystic fibrosis and bronchiectasis: clinical and laboratory parameters of a pilot study. (12200905)
2002
48
Distribution and severity of bronchiectasis in allergic bronchopulmonary aspergillosis (ABPA). (10724299)
2000
49
Bronchiectasis: the 'other' obstructive lung disease. (10418580)
1999
50
Dextrocardia: A Report of Six Cases, Four Presenting Pulmonary Complications, Two of Which Present Marked Bronchiectasis. (21409057)
1932

Genetic Variations for Bronchiectasis

Expression for genes affiliated with Bronchiectasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bronchiectasis

Search GEO for disease gene expression data for Bronchiectasis.

Pathways for genes affiliated with Bronchiectasis

Sources:
54Reactome, 30KEGG, 12EMD Millipore, 50PharmGKB, 52QIAGEN
See all sources

Pathways related to Bronchiectasis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4SCNN1B, SCNN1A, SCNN1G
210.4SCNN1G, SCNN1A, SCNN1B
310.4SCNN1B, SCNN1A, SCNN1G
410.4SCNN1B, SCNN1A, SCNN1G
510.4ELANE, MMP8, CTSG
6
Hide members
10.4MBL2, FCN2
7
Hide members
10.4CFTR, SCNN1G, SCNN1A, SCNN1B
8
NO-dependent CFTR activation (normal and CF)
10.4CFTR, SCNN1G, SCNN1A, SCNN1B
9
CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
10.4CFTR, SCNN1G, SCNN1A, SCNN1B
10
Immune response Bacterial infections in normal airways
10.4CFTR, IL8, TLR2
1110.4IL8, SCNN1A, TLR2
1210.3TAP2, MPO, MBL2, TLR2

Compounds for genes affiliated with Bronchiectasis

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Bronchiectasis according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1h2o24510.8CFTR, CTSG, MMP8, MPO
2hocl4510.8SERPINA1, ELANE, MMP8, MPO, CTSG
3endotoxin4510.8SLPI, RNASE3, CTSG, BPI
4superoxide45 2411.7MBL2, MMP8, ELANE, SERPINA3, SLPI
5zymosan4510.7RNASE3, ELANE, MBL2, TLR2, MPO
6serine4510.7MMP8, SERPINA3, CTSG, MPO, IL8, TLR2
7amiloride45 29 1112.7CFTR, MPO, SCNN1B, SCNN1G, SCNN1A
8fmlp4510.7BPI, CTSG, RNASE3, SERPINA3, MPO, ELANE
9lipoteichoic acid4510.7MBL2, TLR2, IL8, BPI, SLPI
10methacholine45 1111.7MPO, CTSG, RNASE3, IL8, IGHE, SLPI
11fluticasone propionate45 50 60 1113.7IL8, IGHE, RNASE3, MPO, SLPI, ELANE
12n-formylmethionyl-leucylphenylalanine4510.7CTSG, MPO, RNASE3, IL8, ELANE
13triamterene45 11 2412.7SCNN1B, SCNN1A, SCNN1G
14urea45 11 2412.7SLPI, MMP8, SERPINA3, BPI, CTSG, RNASE3
15leukotriene b445 60 2412.7MPO, CTSG, ELANE, TLR2, RNASE3, IL8
16cyclosporin a45 29 6012.7ELANE, MMP8, SLPI, CFTR, IGHE, RNASE3
17anti-fungal4510.7SLPI, RNASE3, MBL2, TLR2, BPI
18diisopropylfluorophosphate4510.7CTSG, SERPINA1, SERPINA3, ELANE
19dexamethasone45 50 29 1113.7IGHE, TLR2, RNASE3, SLPI, CFTR, SCNN1A
20polymyxin b4510.7IL8, BPI, TLR2, MBL2
21anaphylatoxin4510.7MPO, RNASE3, ELANE, IL8
22sodium45 2411.7CTSG, SLPI, CFTR, MBL2, SCNN1B, SCNN1A
23aprotinin45 1111.6ELANE, CTSG, IGHE, IL8, SLPI
24heparin45 29 11 2413.6ELANE, SERPINA1, SLPI, SERPINA3, IL8, CTSG
25polysaccharide4510.6BPI, TLR2, MBL2, CTSG, IGHE, FCN2
26chlorine45 2411.6CFTR, ELANE, RNASE3, IGHE
27budesonide45 50 1112.6MPO, IL8, IGHE, RNASE3
28lactate4510.6ELANE, CTSG, BPI, IL8, MPO, SLPI
29fibrinogen4510.6MMP8, SLPI, SERPINA1, SERPINA3, ELANE, CTSG
30creatinine4510.6CTSG, MPO, MBL2, IGHE, RNASE3, SLPI
31actinomycin d4510.6SCNN1A, CFTR, IL8, IGHE, TLR2, BPI
32histamine45 29 2412.6SLPI, IL8, RNASE3, MPO, CTSG, TLR2
33acetylcholine45 50 29 11 2414.6ELANE, MPO, CFTR, SERPINA3
34cysteine4510.6SERPINA1, CFTR, ELANE, SCNN1G, TLR2, CTSG
35nitric oxide45 11 2412.6TLR2, BPI, SERPINA1, SLPI, MMP8, IL8
36retinoic acid45 2411.6ELANE, SERPINA3, SLPI, MMP8, RNASE3, IGHE
37alanine4510.6SLPI, BPI, IGHE, MMP8, CFTR, CTSG
38vegf4510.5RNASE3, IL8, MMP8, SLPI, IGHE, MPO
39cytochalasin b4510.5CTSG, MPO, RNASE3, ELANE
40carbohydrates4510.5CTSG, MBL2, IGHE, RNASE3, CFTR
41vitamin d4510.5TLR2, ELANE, SLPI, CFTR, IGHE, MBL2
42cilomilast4510.5ELANE, IL8, MPO
43ethanol45 50 11 2413.5TLR2, MBL2, SLPI, BPI, RNASE3, SERPINA1
44oxygen45 2411.5MPO, IL8, SLPI, SERPINA1, ELANE, MMP8
45peptidoglycan45 2911.5MBL2, TLR2, IL8, CTSG
46chloramine t4510.4MPO, ELANE, SLPI
47valine4510.4CFTR, SERPINA3, ELANE
48cetirizine45 29 11 2413.3RNASE3, IL8, IGHE
49estrogen4510.2CFTR, SLPI, IGHE, SERPINA3, ELANE, RNASE3
50nedocromil sodium4510.1IL8, RNASE3, IGHE

GO Terms for genes affiliated with Bronchiectasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Bronchiectasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium channel complexGO:03470610.5SCNN1B, SCNN1A, SCNN1G
2apical plasma membraneGO:01632410.4CFTR, SCNN1G, SCNN1A, SCNN1B
3cell surfaceGO:00998610.3TLR2, MBL2, CTSG, CFTR, ELANE
4extracellular spaceGO:00561510.3MBL2, CTSG, MPO, IL8, MMP8, SERPINA1
5external side of plasma membraneGO:00989710.3TLR2, SCNN1B, SCNN1A, SCNN1G
6extracellular regionGO:00557610.2ELANE, BPI, MBL2, CTSG, IGHE, RNASE3
7secretory granuleGO:03014110.1ELANE, MPO, CTSG

Biological processes related to Bronchiectasis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1sensory perception of tasteGO:05090910.7SCNN1B, SCNN1A, SCNN1G
2excretionGO:00758810.7SCNN1G, SCNN1A, SCNN1B
3acute-phase responseGO:00695310.6SERPINA3, SERPINA1, MBL2
4response to yeastGO:00187810.6ELANE, MPO
5negative regulation of growth of symbiont in hostGO:04413010.6ELANE, MPO, CTSG, MBL2, TLR2
6response to stimulusGO:05089610.6SCNN1B, SCNN1A, SCNN1G
7positive regulation of immune responseGO:05077810.6CTSG, ELANE
8immune responseGO:00695510.6BPI, TLR2, CTSG, IGHE, IL8
9negative regulation of endopeptidase activityGO:01095110.5SERPINA3, SERPINA1, SLPI
10opsonizationGO:00822810.5MBL2, FCN2
11complement activation, lectin pathwayGO:00186710.5MBL2, FCN2
12sodium ion transportGO:00681410.4SCNN1B, SCNN1A, SCNN1G
13defense response to bacteriumGO:04274210.4RNASE3, MBL2, BPI
14transmembrane transportGO:05508510.3CFTR, TAP2, SCNN1G, SCNN1A, SCNN1B
15extracellular matrix disassemblyGO:02261710.1CTSG, MMP8, ELANE

Molecular functions related to Bronchiectasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ligand-gated sodium channel activityGO:01528010.4SCNN1G, SCNN1A, SCNN1B
2serine-type endopeptidase inhibitor activityGO:00486710.4SERPINA3, SERPINA1, SLPI
3WW domain bindingGO:05069910.3SCNN1G, SCNN1A, SCNN1B
4protein bindingGO:0055159.8SCNN1G, SCNN1A, SCNN1B, MBL2, TLR2, IL8

Products for genes affiliated with Bronchiectasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bronchiectasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet