Aliases & Classifications for Bronchiectasis

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Sources:
60UMLS, 9Disease Ontology, 11DISEASES, 43Novoseek, 22GTR, 55SNOMED-CT, 38NCIt, 27ICD9CM, 33MeSH, 25ICD10
See all sources

Bronchiectasis, Aliases & Descriptions:

Name: Bronchiectasis 9 11 43 22 60
Polynesian Bronchiectasis 9
 
Kartagener Syndrome 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology9 DOID:9563
NCIt38 C84475
ICD9CM27 494
MeSH33 D001987
ICD1025 J47

Summaries for Bronchiectasis

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Disease Ontology:9 A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

MalaCards based summary: Bronchiectasis, also known as polynesian bronchiectasis, is related to cystic fibrosis and aspergillosis. An important gene associated with Bronchiectasis is DNAI1 (dynein, axonemal, intermediate chain 1), and among its related pathways are Aldosterone-regulated sodium reabsorption and Sodium channels and transporters inward current. The drug acetylcysteine and the compounds trypsinogen and dermatan sulfate have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and testes, and related mouse phenotypes are respiratory system and immune system.

Wikipedia:63 Bronchiectasis is a disease in which there is permanent enlargement of parts of the airways of the lung.... more...

Related Diseases for Bronchiectasis

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Diseases related to Bronchiectasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1cystic fibrosis30.8CFTR, BPI, CTSG, ELANE
2aspergillosis30.8ELANE
3ciliary dyskinesia, primary, 1, with or without situs inversus30.6DNAI1, CFTR
4bronchitis30.6ELANE, CFTR
5cholangitis30.5CFTR
6respiratory failure30.1ELANE, CFTR
7asthma30.1ELANE, MMP8, CTSG
8aneurysm29.9MMP8, ELANE
9ulcerative colitis29.9BPI, CTSG
10vasculitis29.8CTSG, ELANE, BPI
11acute respiratory distress syndrome29.8ELANE, CTSG
12pneumonia29.7ELANE, MMP8, BPI, CFTR, CTSG
13pulmonary emphysema29.5MMP8, ELANE, CTSG
14rheumatoid arthritis29.4CTSG, BPI, MMP8, CFTR, ELANE
15idiopathic bronchiectasis10.5
16primary ciliary dyskinesia10.3
17pseudohypoaldosteronism, type i10.3SCNN1A, SCNN1B
18emphysema due to aat deficiency10.3ELANE
19bronchiectasis with or without elevated sweat chloride 210.3
20sinusitis10.3
21dextrocardia10.3
22allergic bronchopulmonary aspergillosis10.3
23tuberculosis10.3
24pulmonary function10.2
25bronchiectasis with or without elevated sweat chloride 110.2
26bronchiectasis with or without elevated sweat chloride 310.2
27common variable immunodeficiency10.2
28yellow nail syndrome10.2
29gastroesophageal reflux10.2
30ciliary dyskinesia-bronchiectasis10.2
31periodontal disease10.2ELANE
32reactive arthritis10.2BPI, MMP8
33arthritis10.2
34influenza10.2
35liddle syndrome10.2SCNN1G, SCNN1B, SCNN1A
36hypertension, essential10.1SCNN1A, SCNN1G, SCNN1B
37alcoholic pancreatitis10.1CFTR, ELANE
38steatorrhea10.1CFTR, ELANE
39exocrine pancreatic insufficiency10.1ELANE, CFTR
40pancreas disease10.1CFTR, ELANE
41keratoconus10.1CTSG, MMP8
42situs inversus10.1
43agammaglobulinemia10.1
44amyloidosis10.1
45aspiration pneumonia10.1
46esophagitis10.1
47obstructive lung disease10.1
48thyroiditis10.1
49bronchiectasis oligospermia10.1
50haemophilus influenzae10.1

Graphical network of the top 20 diseases related to Bronchiectasis:



Diseases related to bronchiectasis

Symptoms for Bronchiectasis

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Drugs & Therapeutics for Bronchiectasis

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Drug clinical trials:

Search ClinicalTrials for Bronchiectasis

Search NIH Clinical Center for Bronchiectasis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Bronchiectasis

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Genetic tests related to Bronchiectasis:

id Genetic test Affiliating Genes
1 Bronchiectasis22

Anatomical Context for Bronchiectasis

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MalaCards organs/tissues related to Bronchiectasis:

31
Lung, Neutrophil, Testes, Colon, Thyroid, Bone, Kidney, Bone marrow, Lymph node, Brain, Smooth muscle, Breast, Myeloid, Monocytes, T cells, B cells

Animal Models for Bronchiectasis or affiliated genes

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MGI Mouse Phenotypes related to Bronchiectasis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5DNAI1, SCNN1G, SCNN1A, SCNN1B, CFTR
2MP:00053877.9MMP8, ELANE, DNAI1, CTSG, CFTR
3MP:00028737.5CTSG, ELANE, SCNN1G, SCNN1A, SCNN1B, CFTR
4MP:00107687.2CTSG, CFTR, SCNN1B, SCNN1A, SCNN1G, ELANE

Publications for Bronchiectasis

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Articles related to Bronchiectasis:

(show top 50)    (show all 661)
idTitleAuthorsYear
1
A rare cause of bronchiectasis. (25849059)
2015
2
Bronchiectasis: A retrospective study of clinical and aetiological investigation in a general respiratory department. (25854129)
2015
3
Impact of Different Etiologies of Bronchiectasis on the Pulmonary Function Tests. (25380609)
2014
4
The prevalence of bronchiectasis in patients with Marfan syndrome. (25199019)
2014
5
Expression of soluble triggering receptor expressed on myeloid cells-1 in childhood CF and Non-CF bronchiectasis. (25348906)
2014
6
Quality of Life Questionnaire-Bronchiectasis: final psychometric analyses and determination of minimal important difference scores. (25323621)
2014
7
Epicardially originating ventricular tachycardia: an unusual presentation of bronchiectasis. (23365070)
2013
8
Validation of a Quality of Life Questionnaire for Bronchiectasis: psychometric analyses of the Spanish QOL-B-V3.0. (24142190)
2013
9
Molecular epidemiological analysis suggests cross infection with Pseudomonas aeruginosa is rare in Non-Cystic Fibrosis bronchiectasis. (24176999)
2013
10
Depression and anxiety symptoms in bronchiectasis: associations with health-related quality of life. (22544417)
2013
11
Surgical treatment of bronchiectasis: a retrospective observational study of 138 patients. (23825752)
2013
12
Lung transplantation for cystic fibrosis and bronchiectasis. (23821505)
2013
13
Indigenous children from three countries with non-cystic fibrosis chronic suppurative lung disease/bronchiectasis. (23401398)
2013
14
Mannose-binding lectin and innate immunity in bronchiectasis. (24429113)
2013
15
Bronchiectasis exacerbation study on azithromycin and amoxycillin-clavulanate for respiratory exacerbations in children (BEST-2): study protocol for a randomized controlled trial. (23421781)
2013
16
Microbes in bronchiectasis: the forest or the trees? (23675713)
2013
17
Quantitative and qualitative computed tomographic characteristics of bronchiectasis in 12 dogs. (23578226)
2013
18
Pulmonary rehabilitation for patients with bronchiectasis: case reports. (22510678)
2012
19
Focal bronchiectasis causing abnormal pulmonary radioiodine uptake in a patient with well-differentiated papillary thyroid carcinoma. (23097725)
2012
20
Bronchiectasis in chronic pulmonary aspiration: risk factors and clinical implications. (22028069)
2012
21
Pathogenesis of bronchiectasis. (22640841)
2012
22
Immune regulation in idiopathic bronchiectasis. (23231716)
2012
23
Inhaled gentamicin in non-cystic fibrosis bronchiectasis: effects of long-term therapy. (21470074)
2011
24
Risk of infections in bronchiectasis during disease-modifying treatment and biologics for rheumatic diseases. (22046967)
2011
25
Infection and remodelling: a 21st century model of bronchiectasis? (21965500)
2011
26
Lady Windermere revisited: treatment with thoracoscopic lobectomy/segmentectomy for right middle lobe and lingular bronchiectasis associated with non-tuberculous mycobacterial disease. (21324708)
2011
27
Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century. (20709772)
2010
28
Pneumatosis intestinalis presenting with a pneumoperitoneum in a patient with chronic bronchiectasis: a delayed diagnosis of superior mesenteric artery ischaemia. (22767661)
2010
29
British Thoracic Society guideline for non-CF bronchiectasis. (20627912)
2010
30
Cardiac herniation following completion pneumonectomy for bronchiectasis. (20826968)
2010
31
Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand. (20854242)
2010
32
A decade of non-cystic fibrosis bronchiectasis 1996-2006. (20666070)
2010
33
Respiratory bacterial pathogens in the nasopharynx and lower airways of Australian indigenous children with bronchiectasis. (20656297)
2010
34
Stable bronchiectasis is associated with low serum L-ficolin concentrations. (20298369)
2009
35
Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening. (19616787)
2009
36
Exhaled breath condensate MMP-9 levels in children with bronchiectasis. (19725099)
2009
37
Bronchiectasis: pathophysiology, presentation and management. (18837280)
2008
38
Congenital lymphoedema, bronchiectasis and seizure: case report. (18663889)
2008
39
Bronchiectasis, part 2: Management. (20046814)
2008
40
Bronchiectasis in adults: a review. (18824830)
2008
41
Upregulation of ICAM-1 expression in bronchial epithelial cells by airway secretions in bronchiectasis. (17931847)
2008
42
Re: A retrospective study of the relationship between tracheal collapse and bronchiectasis in dogs. (18018738)
2007
43
IFN gamma and CXCR-1 gene polymorphisms in idiopathic bronchiectasis. (17026468)
2006
44
Bronchiectasis worsening by p-ANCA (bactericidal/permeability-increasing protein) positive vasculitis. A case report and review of the literature]. (16610259)
2005
45
Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis. (14985560)
2004
46
CFTR gene mutations in adults with disseminated bronchiectasis. (9272738)
1997
47
Bronchiectasis and homozygous (P1ZZ) alpha 1-antitrypsin deficiency. (8711667)
1996
48
Sputum sol phase proteins and elastase activity in patients with clinically stable bronchiectasis. (1372451)
1992
49
Simulated dextrocardia associated with bronchiectasis; report of case. (20280493)
1946
50
Dextrocardia and bronchiectasis, a review of the literature and a report of two cases. (20996259)
1946

Variations for Bronchiectasis

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Clinvar genetic disease variations for Bronchiectasis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1DNAI1NM_001184940.1(FAM219A): c.-792dupduplicationPathogenicrs397515363GRCh37Chr 9, 34459053: 34459053
2DNAI1NM_012144.3(DNAI1): c.1543G> A (p.Gly515Ser)single nucleotide variantPathogenicrs79833450GRCh37Chr 9, 34513163: 34513163
3DNAI1NM_012144.3(DNAI1): c.1490G> A (p.Gly497Asp)single nucleotide variantPathogenicrs376252276GRCh37Chr 9, 34513110: 34513110
4DNAI1NM_012144.3(DNAI1): c.2001+1G> Asingle nucleotide variantPathogenicrs397515563GRCh37Chr 9, 34517466: 34517466

Expression for genes affiliated with Bronchiectasis

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Search GEO for disease gene expression data for Bronchiectasis.

Pathways for genes affiliated with Bronchiectasis

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Pathways related to Bronchiectasis according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2SCNN1G, SCNN1B, SCNN1A
2
Show member pathways
9.2SCNN1A, SCNN1B, SCNN1G
39.2SCNN1A, SCNN1B, SCNN1G
4
Show member pathways
9.2SCNN1A, SCNN1B, SCNN1G
5
Show member pathways
9.2SCNN1B, SCNN1A, SCNN1G
6
Show member pathways
8.9CFTR, SCNN1B, SCNN1A, SCNN1G
78.9CFTR, SCNN1G, SCNN1A, SCNN1B
88.9CFTR, SCNN1B, SCNN1A, SCNN1G
9
Show member pathways
8.9SCNN1B, SCNN1A, CFTR, SCNN1G
10
Show member pathways
8.6CTSG, MMP8, ELANE
11
Show member pathways
8.6MMP8, ELANE, CTSG

Compounds for genes affiliated with Bronchiectasis

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Compounds related to Bronchiectasis according to GeneCards Suite gene sharing:

(show all 43)
idCompoundScoreTop Affiliating Genes
1trypsinogen4310.0CFTR, ELANE
2dermatan sulfate439.8CFTR, ELANE
3batimastat43 59 1211.7MMP8, ELANE
4salicylic acid43 2810.7DNAI1, CFTR
5triamterene43 24 1211.7SCNN1B, SCNN1A, SCNN1G
6polysulfone439.7BPI, ELANE
74-nitroanilide439.5CTSG, ELANE
8elastatinal439.5CTSG, ELANE
9saccharin43 210.5ELANE, CTSG
10thermolysin439.5ELANE, CTSG
11chymostatin439.5ELANE, CTSG
12pmsf439.5CTSG, ELANE
13doxycycline43 1210.5ELANE, MMP8
14epsilon aminocaproic acid439.5CTSG, ELANE
15phosphonate439.5CTSG, MMP8
16diisopropylfluorophosphate439.4CTSG, ELANE
17phosphoramidon43 1210.4ELANE, CTSG
18cytochalasin b439.4CTSG, ELANE
19actinomycin d439.4SCNN1A, CFTR, BPI
20n-formylmethionyl-leucylphenylalanine439.3ELANE, CTSG
21amiloride43 28 1211.3SCNN1G, SCNN1A, SCNN1B, CFTR
22cyclosporin a43 28 5911.3CFTR, ELANE, MMP8
23xanthine43 2410.3CTSG, MMP8
24pge2439.3CFTR, MMP8, ELANE
25kininogen439.2CTSG, ELANE
26aspirin43 49 28 2412.1ELANE, CTSG, CFTR
27aprotinin43 1210.1ELANE, CTSG
28epinephrine43 24 1211.1CFTR, CTSG, ELANE
29(4-aminophenyl)mercuric acetate439.0CTSG, ELANE, MMP8
30hocl439.0MMP8, ELANE, CTSG
31urea43 24 1210.9CTSG, BPI, MMP8
32fibrinogen438.9ELANE, CTSG, MMP8
33endotoxin438.9BPI, CTSG, ELANE
34fmlp438.9CTSG, BPI, ELANE
35h2o2438.7MMP8, CTSG, CFTR, ELANE
36superoxide43 249.6MMP8, ELANE, CTSG
37alanine438.5CFTR, BPI, MMP8, CTSG
38sodium43 249.5SCNN1B, CTSG, SCNN1G, SCNN1A, CFTR
39lactate438.4BPI, ELANE, CTSG, MMP8
40heparin43 28 24 1211.2CTSG, ELANE, BPI
41retinoic acid43 249.1ELANE, BPI, CTSG, MMP8, CFTR
42serine438.0CTSG, CFTR, MMP8, ELANE, BPI
43cysteine437.6ELANE, MMP8, BPI, CFTR, CTSG, SCNN1G

GO Terms for genes affiliated with Bronchiectasis

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Cellular components related to Bronchiectasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sodium channel complexGO:00347069.4SCNN1G, SCNN1A, SCNN1B
2external side of plasma membraneGO:00098979.2SCNN1G, SCNN1A, SCNN1B
3secretory granuleGO:00301419.1CTSG, ELANE
4apical plasma membraneGO:00163249.0CFTR, SCNN1B, SCNN1A, SCNN1G
5integral component of plasma membraneGO:00058878.5SCNN1B, SCNN1A, SCNN1G, BPI
6cell surfaceGO:00099868.5CTSG, ELANE, CFTR
7extracellular vesicular exosomeGO:00700627.3SCNN1B, SCNN1A, SCNN1G, ELANE, BPI, CTSG

Biological processes related to Bronchiectasis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal water homeostasisGO:00508919.5SCNN1G, SCNN1A, SCNN1B
2sodium ion homeostasisGO:00550789.5SCNN1B, SCNN1G, SCNN1A
3sensory perception of tasteGO:00509099.5SCNN1G, SCNN1A, SCNN1B
4excretionGO:00075889.5SCNN1B, SCNN1A, SCNN1G
5response to stimulusGO:00508969.5SCNN1B, SCNN1A, SCNN1G
6sodium ion transportGO:00068149.5SCNN1B, SCNN1A, SCNN1G
7sodium ion transmembrane transportGO:00357259.4SCNN1A, SCNN1G, SCNN1B
8collagen catabolic processGO:00305749.4MMP8, ELANE
9positive regulation of immune responseGO:00507789.3CTSG, ELANE
10ion transmembrane transportGO:00342209.2SCNN1G, SCNN1A, SCNN1B
11negative regulation of growth of symbiont in hostGO:00441309.2CTSG, ELANE
12transmembrane transportGO:00550859.0SCNN1B, SCNN1A, SCNN1G, CFTR
13extracellular matrix disassemblyGO:00226178.8ELANE, CTSG, MMP8
14proteolysisGO:00065088.5MMP8, CTSG, ELANE
15extracellular matrix organizationGO:00301988.3MMP8, ELANE, CTSG

Molecular functions related to Bronchiectasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ligand-gated sodium channel activityGO:00152809.2SCNN1G, SCNN1A, SCNN1B
2WW domain bindingGO:00506999.1SCNN1B, SCNN1A, SCNN1G
3peptidase activityGO:00082339.1CTSG, ELANE
4serine-type endopeptidase activityGO:00042528.3CTSG, ELANE, MMP8

Products for genes affiliated with Bronchiectasis

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Sources for Bronchiectasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet