Bronchiectasis malady

Disease Ontology: A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.⁶

MalaCards: Bronchiectasis, also known as polynesian bronchiectasis, is related to asthma and bronchitis. An important gene associated with Bronchiectasis is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)), and among its related pathways are Bacterial infections in CF airways and NO-dependent CFTR activation (normal and CF). The drug acetylcysteine and the compounds vegf and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and lung, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Wikipedia: Bronchiectasis is a disease state defined by localized, irreversible dilation of part of the bronchial...⁴⁴ more...

Aliases & Descriptions:

bronchiectasis 6 8 32 43 polynesian bronchiectasis 6

kartagener syndrome 43

Diseases related to bronchiectasis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 826)

id	Related Disease	Score	Top Affiliating Genes
1	asthma	31.5	IGES, IGHE, RNASE3, ADRB2
2	bronchitis	29.6	SERPINA1, SERPINB1, CFTR, MPO, IL8, IGHE
3	kartagener syndrome	29.4	CFTR, CCDC40, CCDC39, RSPH4A, RSPH9, DNAAF2
4	primary ciliary dyskinesia	29.2	CFTR, CCDC40, CCDC39, AK7, RSPH4A, RSPH9
5	rheumatoid arthritis	29.1	MBL2, HLA-DRB1, LTA
6	situs inversus	28.8	SERPINA1, CCDC40, CCDC39, RSPH4A, RSPH9, DNAAF2
7	allergic bronchopulmonary aspergillosis	28.6	CFTR, MBL2, IGES, IGHE
8	arthritis	28.4	SERPINA1, IL1B, IL6, IL8, TNF, CTSG
9	obstructive lung disease	27.0	SERPINA1, SERPINA3, IGHE, ALB, TNF, RNASE3
10	ciliary dyskinesia	26.9	SCNN1A, SCNN1B, SCNN1G, CFTR, CCDC40, CCDC39
11	mycobacterial infection	26.4	SERPINA1, CFTR, IL10, IL6, MBL2, IFNG
12	idiopathic pulmonary fibrosis	26.2	CD36, MMP1, MMP9, IL1B, IL8, IFNG
13	alpha 1-antitrypsin deficiency	26.0	SERPINA1, SERPINA3, SERPINB1, BPI, CFTR, MPO
14	chronic obstructive pulmonary disease	25.8	SERPINA1, SERPINA3, SERPINB1, CFTR, MPO, MMP1
15	polycystic kidney disease	25.5	CFTR, CD79A, MMP9, ALB, HMOX1, HLA-B
16	aspergillosis	25.4	CFTR, CD79A, CD4, FLNC, IL10, IL1B
17	common variable immunodeficiency	25.1	BTK, SERPINA1, SCNN1A, SCNN1B, SCNN1G, MPO
18	immunodeficiency	24.8	BTK, BPI, CD79A, CD4, IL10, IL6
19	cystic fibrosis	23.6	SERPINA1, SERPINA3, SERPINB1, BPI, SCNN1A, SCNN1B
20	vasculitis	22.3	SERPINA1, SERPINA3, SERPINB1, BPI, MPO, CD79A
21	fibrosis	22.2	SERPINA1, SERPINA3, SERPINB1, BPI, SCNN1A, SCNN1B
22	pulmonary disease	22.0	SERPINA1, SERPINA3, SERPINB1, SCNN1G, CFTR, MPO
23	bronchial asthma	20.8	CFTR, MPO, CD79A, CD14, CD4, MMP14
24	copd	20.7	SERPINA1, SERPINA3, SERPINB1, BPI, CFTR, MPO
25	pulmonary fibrosis	20.5	SERPINA1, SERPINB1, MPO, CD36, MMP1, MMP9
26	pneumonia	18.8	BTK, SERPINA1, SERPINB1, BPI, CFTR, MPO
27	acute febrile neutrophilic dermatosis	13.9	SERPINA3, CTSG, ELANE
28	alpha-1-antichymotrypsin deficiency	13.9	SERPINA1, SERPINA3, CTSG
29	pseudohypoaldosteronism type i	13.9	SCNN1A, SCNN1B, SCNN1G
30	cystic fibrosis lung disease	13.9	CFTR, MPO, IL8, MBL2, ELANE
31	liddle syndrome	13.9	SCNN1A, SCNN1B, SCNN1G, CFTR
32	chronic sphenoidal sinusitis	13.9	CFTR, IL8, IGES, IGHE, RNASE3, ELANE
33	intrinsic asthma	13.9	IGES, IGHE, RNASE3
34	pseudohypoaldosteronism	13.8	SCNN1A, SCNN1B, SCNN1G, CFTR
35	bacteremia, protection against	13.8	BPI, MBL2, SLPI
36	respiratory failure	13.8	CFTR, IGES, IGHE, RNASE3, ELANE, ADRB2
37	allergic rhinitis	13.7	IGES, IGHE, RNASE3
38	chronic rhinitis	13.7	MPO, RNASE3, EDN1
39	primary sclerosing cholangitis	13.7	BPI, CFTR, MPO, HLA-A, CTSG, ELANE
40	kimura disease	13.7	IGES, IGHE, RNASE3
41	dextrocardia	13.7	RSPH9, DNAH5, DNAI1, DNAH11
42	eosinophilic gastroenteritis	13.7	IGES, IGHE, ALB, RNASE3
43	extrinsic allergic alveolitis	13.7	CD14, IL8, IGHE
44	bacterial meningitis	13.7	MMP8, IL1B, IL8, TLR2
45	hereditary pancreatitis	13.7	SERPINA1, CFTR, CD36, IGES, ELANE
46	immunodeficiency with hyper igm type 1	13.7	BTK, CD79A, IGHE
47	b cell deficiency	13.6	BTK, CD79A, IGHE
48	pasteurellosis	13.6	MPO, ALB, ELANE, SLPI
49	stenotrophomonas maltophilia	13.6	BPI, IL10, IL8
50	reactive arthritis	13.6	BPI, CD79A, MMP8, HLA-B, TAP2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acetylcysteine

MalaCards organs/tissues related to bronchiectasis:

²²

MGI Mouse Phenotypes related to bronchiectasis:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	INF	PKD1, NOS2, TNFRSF13B, HLA-DQB1, HMOX1, ALB
2	cardiovascular system phenotype	MP:0005385	INF	LTA, PKD1, NOS2, TNF, HLA-DQB1, EDN1
3	respiratory system phenotype	MP:0005388	INF	DNAH11, SCNN1A, SERPINB1, SCNN1B, SCNN1G, CFTR
4	muscle phenotype	MP:0005369	INF	HMOX1, HLA-DQB1, TNF, NOS2, PKD1, EDN1
5	endocrine/exocrine gland phenotype	MP:0005379	9.8	TLR2, LTA, IFNG, MST1R
6	renal/urinary system phenotype	MP:0005367	9.7	CXCR4, DNAH11, DNAH5, PKD1, TNFRSF13B, CCDC40
7	hematopoietic system phenotype	MP:0005397	9.5	TAP1, DNAH11, DNAH5, CTSG, TNFRSF13B, HLA-DQB1
8	liver/biliary system phenotype	MP:0005370	9.0	CTSG, PKD1, TLR2, DNAH5, DNAH11, TNFRSF13B
9	growth/size phenotype	MP:0005378	9.0	CCDC40, AK7, PKD1, LTA, DNAH5, DNAI1
10	skeleton phenotype	MP:0005390	8.9	CXCR4, DNAH5, PKD1, IL6, FLNB, MMP9
11	nervous system phenotype	MP:0003631	8.4	EDN1, TLR2, DNAH5, DNAI1, TAP1, CXCR4
12	digestive/alimentary phenotype	MP:0005381	7.7	IFNG, NOS2, PKD1, EDN1, TLR2, DNAH5
13	normal phenotype	MP:0002873	7.6	HLA-DQB1, CTSG, PKD1, ELANE, TLR2, DNAH11
14	immune system phenotype	MP:0005387	7.2	BTK, IL6, MMP8, MMP14, ITGAV, CD4
15	mortality/aging	MP:0010768	6.4	CTSG, TNFRSF13B, HLA-DQB1, HMOX1, AK7, IFNG
16	behavior/neurological phenotype	MP:0005386	6.4	IFNG, HMOX1, HLA-DQB1, TNF, NOS2, LTA
17	cellular phenotype	MP:0005384	INF	ICAM1, HMOX1, HLA-DQB1, TNF, TNFRSF13B, NOS2
18	integument phenotype	MP:0010771	INF	TAP1, TLR2, PKD1, IFNG, , FLNC
19	tumorigenesis	MP:0002006	INF	TNF, TNFRSF13B, CTSG, NOS2, ELANE, TLR2
20	craniofacial phenotype	MP:0005382	INF	DNAH5, EDN1, PKD1, AK7, , FLNB

Articles related to bronchiectasis:

(show top 50)    (show all 73)

id	Title	Authors	Year	Affiliating Genes
1	Mutations of the cystic fibrosis gene in patients wit h bronchiectasis associated with rheumatoid arthritis. (21131649)	PuAcchal X.... Dusser D.J.	2011	CFTR
2	Novel cftr gene sequence variation in Serbian patient with idiopathic disseminated bronchiectasis. (20334484)	Nikolic A.... Nestorovic B.	2010	CFTR
3	Development of novel microarray methodology for the s tudy of mutations in the SERPINA1 and ADRB2 genes--their association with Obstr uctive Pulmonary Disease and Disseminated Bronchiectasis in Greek patients. (19747908)	Papatheodorou A.... Tzetis M.	2010	SERPINA1, ADRB2
4	Cystic fibrosis transmembrane conductance regulator c hannel dysfunction in non-cystic fibrosis bronchiectasis. (20167849)	Bienvenu T.... Fajac I.	2010	CFTR
5	Exhaled breath condensate MMP-9 levels in children wi th bronchiectasis. (19725099)	Karakoc G.B.... Kendirli S.G.	2009	ELANE
6	Matrix metalloproteinases gene variants in idiopathic disseminated bronchiectasis. (19188843)	Stankovic M.... Radojkovic D.	2009	MMP9, MMP1
7	Upregulation of ICAM-1 expression in bronchial epithe lial cells by airway secretions in bronchiectasis. (17931847)	Chan S.C.... Ip M.S.	2008	ICAM1
8	Autosomal dominant polycystic kidney disease is associated with an increased prevalence of radiographic bronchiectasis. (18263686)	Driscoll J.A.... Brody S.L.	2008	PKD1
9	Human leucocyte antigen class II association in idiopathic bronchiectasis, a disease of chronic lung infection, implicates a role for adaptive immunity. (18241227)	Boyton R.J.... Altmann D.M.	2008	HLA-DQA1, HLA-A, HLA-DQB1
10	The Whim syndrome: a rare cause of diffuse bronchiectasis. Immune defect of CXCR4 and chronic bronchial suppuration (18535531)	Vinurel H.... Devouassoux G.	2008	CXCR4
11	Withdrawal of inhaled steroids in children with non-cystic fibrosis bronchiectasis. (19138237)	Guran T.... Dagli E.	2008	IL8
12	Could a defective epithelial sodium channel lead to bronchiectasis. (18507830)	Fajac I.... Bienvenu T.	2008	CFTR, SCNN1B, SCNN1G
13	Lack of association between the microsatellite polymorphism in intron 2 of human Toll-like receptor 2 gene and bronchiectasis among Koreans. (17207025)	Kim H.J.... Yim J.J.	2007	TLR2
14	Dissociation of lung function, dyspnea ratings and pulmonary extension in bronchiectasis. (17698334)	MartA-nez-GarcA-a M.A.... GonzA!lez-Molina A.	2007	TTF2
15	Lack of association between matrix metalloproteinase 8 promoter polymorphism and bronchiectasis in Koreans. (17728507)	Lee J.... Yim J.J.	2007	MMP8
16	Toll-like receptors 2 and 4 and innate immunity in neutrophilic asthma and idiopathic bronchiectasis. (17329561)	Reynolds C.... Boyton R.	2007	TLR2
17	Innate immune activation in neutrophilic asthma and bronchiectasis. (16844729)	Simpson J.L.... Gibson P.G.	2007	CD14
18	Airway nitric oxide output is reduced in bronchiectasis. (17234397)	Foley S.C.... McLoughlin P.	2007	NOS2
19	The role of TAP1 and TAP2 gene polymorphism in idiopathic bronchiectasis in children. (17245734)	Dogru D.... Ozguc M.	2007	FLNB, TAP1, TAP2
20	Prospective analysis of cystic fibrosis transmembrane regulator mutations in adults with bronchiectasis or pulmonary nontuberculous mycobacterial infection. (17035430)	Ziedalski T.M.... Ruoss S.J.	2006	CFTR
21	Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis. (16297171)	Fevang B.... land S.S.	2005	MBL2
22	Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis. (14985560)	Watt A.P.... Ennis M.	2004	ELANE
23	Role of CFTR mutations in adult bronchiectasis. (15047968)	King P.T.... Sart D.D.	2004	CFTR
24	Neutrophils, myeloperoxidase, and bronchiectasis in cystic fibrosis: green is not good. (15478278)	Meyer K.C.	2004	MPO
25	High frequency of T9 and CFTR mutations in children with idiopathic bronchiectasis. (12843327)	Ninis V.N.... Tolun A.	2003	CFTR
26	Sputum sol neutrophil elastase activity in bronchiectasis: differential modulation by syndecan-1. (12702549)	Chan S.C.... Ip M.S.	2003	ELANE, SERPINB1
27	A preliminary assessment of alpha-1 antitrypsin S and Z deficiency allele frequencies in common variable immunodeficiency patients with and without bronchiectasis. (12452840)	Sansom M.E.... Chapel H.M.	2002	SERPINA1
28	Effect of sputum processing with dithiothreitol on the detection of inflammatory mediators in chronic bronchitis and bronchiectasis. (12149524)	Woolhouse I.S.... Stockley R.A.	2002	TNF, IL6, MPO
29	Effects of the zhikuofang on the inflammation and cytostatics of the airway model of bronchiectasis (12774391)	Wan Y.G.... Zhou M.	2002	TNF, IL8
30	In vivo collagenase-2 (MMP-8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis. (11400153)	Prikk K.... Sorsa T.	2001	MMP8
31	Sputum elastase in steady-state bronchiectasis. (10669685)	Tsang K.W.... Lam W.	2000	TNF, IL1B, IL8
32	Elevated levels of macrophage-stimulating protein in induced sputum of patients with bronchiectasis. (10955755)	Takano Y.... Ando M.	2000	MST1R, MST1
33	Endothelin-1 in stable bronchiectasis. (10933101)	Zheng L.... Tsang K.W.	2000	EDN1
34	Induced sputum eosinophils and neutrophils and bronchiectasis severity in allergic bronchopulmonary aspergillosis. (11292112)	Wark P.A.... Gibson P.G.	2000	IGES
35	Tumor necrosis factor gene complex in COPD and disseminated bronchiectasis. (10807822)	Patuzzo C.... Luisetti M.	2000	TNF, LTA
36	Increased frequency of cystic fibrosis deltaF508 mutation in bronchiectasis associated with rheumatoid arthritis. (10445602)	PuAcchal X.... Dusser D.J.	1999	CFTR
37	Bronchiectasis with myeloperoxidase antineutrophil cytoplasmic antibody and bactericidal/permeability-increasing protein antineutrophil cytoplasmic antibody. (10526946)	Matsuyama W.... Osame M.	1999	MPO, BPI
38	The chemotactic activity of sputum from patients with bronchiectasis. (9517582)	Mikami M.... Stockley R.A.	1998	IL8
39	Inhaled fluticasone reduces sputum inflammatory indices in severe bronchiectasis. (9730996)	Tsang K.W.... Yuen K.Y.	1998	IL1B, IL8
40	Exhaled nitric oxide is not elevated in the inflammatory airways diseases of cystic fibrosis and bronchiectasis. (9877479)	Ho L.P.... Greening A.P.	1998	NOS2
41	Evidence for eosinophil activation in bronchiectasis unrelated to cystic fibrosis and bronchopulmonary aspergillosis: discrepancy between blood eosinophil counts and serum eosinophil cationic protein levels. (9713451)	Kroegel C.... Grahmann P.R.	1998	RNASE3
42	Increases in CD4+ T lymphocytes, macrophages, neutrophils and interleukin 8 positive cells in the airways of patients with bronchiectasis. (9828857)	Gaga M.... Durham S.R.	1998	IL8
43	CFTR gene mutations in adults with disseminated bronchiectasis. (9272738)	Girodon E.... Goossens M.	1997	CFTR
44	Association of HLA class I antigen deficiency related to a TAP2 gene mutation with familial bronchiectasis. (8523185)	Donato L.... Geisert J.	1995	TAP2
45	Human neutrophil collagenase (MMP-8), identified in bronchiectasis BAL fluid, correlates with severity of disease. (7781360)	Sepper R.... Sorsa T.	1995	MMP8
46	Presence, activities, and molecular forms of cathepsin G, elastase, alpha 1-antitrypsin, and alpha 1-antichymotrypsin in bronchiectasis. (7759598)	Sepper R.... Sorsa T.	1995	ELANE, CTSG, SERPINA3
47	Increased incidence of cystic fibrosis gene mutations in adults with disseminated bronchiectasis. (7543317)	Pignatti P.F.... Luisetti M.	1995	CFTR
48	Sputum sol phase proteins and elastase activity in patients with clinically stable bronchiectasis. (1372451)	Lloberes P.... Picado C.	1992	SERPINA1, ALB, ELANE
49	Mucus hypersecretion in bronchiectasis. The role of n eutrophil proteases. (1280928)	Fahy J.V.... Nadel J.A.	1992	CTSG
50	High prevalence of asthma in patients with bronchiectasis in Hong Kong. (1563501)	Ip M.S.... Liong E.	1992	IGHE, IGES

Genes related to bronchiectasis according to GeneCards:

(show top 50)    (show all 75)

id	Symbol	Description	Score	GeneCards Section Context
1	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0	Publications
2	IGES	immunoglobulin E concentration, serum	11.0	Publications
3	SCNN1G	sodium channel, non-voltage-gated 1, gamma subunit	11.0	Publications
4	CTSG	cathepsin G	11.0	Publications
5	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
6	SCNN1B	sodium channel, non-voltage-gated 1, beta subunit	11.0	Publications
7	BPI	bactericidal/permeability-increasing protein	11.0	Publications
8	SCNN1A	sodium channel, non-voltage-gated 1 alpha subunit	11.0
9	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
10	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
11	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
12	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
13	ELANE	elastase, neutrophil expressed	11.0	Publications
14	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
15	MPO	myeloperoxidase	11.0	Publications
16	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
17	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
18	IL8	interleukin 8	11.0	Publications
19	TLR2	toll-like receptor 2	11.0	Publications
20	RSPH4A	radial spoke head 4 homolog A (Chlamydomonas)	11.0
21	DNAAF2	dynein, axonemal, assembly factor 2	11.0
22	RSPH9	radial spoke head 9 homolog (Chlamydomonas)	11.0
23	JMJD6	jumonji domain containing 6	11.0	Publications
24	MST1	macrophage stimulating 1 (hepatocyte growth factor-like)	11.0	Publications
25	FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	11.0	Publications
26	SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	11.0	Publications
27	CCDC39	coiled-coil domain containing 39	11.0
28	DNAAF1	dynein, axonemal, assembly factor 1	11.0
29	AGFG2	ArfGAP with FG repeats 2	11.0	Disorders
30	DNAI1	dynein, axonemal, intermediate chain 1	11.0	Publications
31	DNAI2	dynein, axonemal, intermediate chain 2	11.0
32	CCDC40	coiled-coil domain containing 40	11.0
33	DNAL1	dynein, axonemal, light chain 1	11.0
34	MST1R	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	11.0	Publications
35	TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	11.0
36	AK7	adenylate kinase 7	11.0
37	TTF2	transcription termination factor, RNA polymerase II	11.0	Publications
38	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
39	FLNC	filamin C, gamma	11.0
40	DNAH5	dynein, axonemal, heavy chain 5	11.0	Publications
41	CXCR1	chemokine (C-X-C motif) receptor 1	11.0	Publications
42	DNAH1	dynein, axonemal, heavy chain 1	11.0
43	PKD1	polycystic kidney disease 1 (autosomal dominant)	11.0	Publications
44	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
45	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0	Publications
46	ITGAV	integrin, alpha V	11.0	Publications
47	FLNB	filamin B, beta	11.0	Publications
48	BTK	Bruton agammaglobulinemia tyrosine kinase	11.0
49	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
50	DNAH11	dynein, axonemal, heavy chain 11	11.0

Pathways related to bronchiectasis according to GeneDecks:

(show top 50)    (show all 89)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.8	CFTR, TLR2
2	NO-dependent CFTR activation (normal and CF)41	10.5	NOS2, CFTR, SCNN1G, SCNN1B, SCNN1A
3	Graft-versus-host disease20	10.4	HLA-B, HLA-DQA1, HLA-A
4	Cell adhesion molecules (CAMs)20	10.4	ITGAV, CD4
5	Primary immunodeficiency20	10.4	TAP2, TAP1, CD4, BTK
6	Cytoplasmic microtubules10	9.9	DNAI1, DNAI2, DNAH9, DNAH11, DNAH1, DNAL1
7	Activation of Matrix Metalloproteinases38	9.9	MMP8, MMP1, MMP14, MMP9, CTSG, ELANE
8	Immune response_Bacterial infections in normal airways41	9.8	IFNG, CD14, IL1B, NOS2, CFTR
9	Amoebiasis20	9.7	CTSG, NOS2, TLR2, IL8, IL6, IL1B
10	LDL Oxidation in Atherogenesis36	9.6	CD36, MPO, IL1B, ICAM1, TNF
11	Antigen processing and presentation20	9.6	CD4, HLA-DRB1, HLA-DQA1, TAP2, TAP1, HLA-DQB1
12	Selected targets of C/EBPalpha10	9.5	MMP8, ELANE, CTSG, CD36, ALB
13	MSP-RON Signaling36	9.4	MST1, IL1B, TLR2, TNF, MST1R, IFNG
14	Th1 Differentiation37	9.2	IFNG, TLR2, LTA, CD4, IL10, TNF
15	Endothelin-1 Signaling Pathway36	9.1	BTK, EDN1, IL6, IL1B, IL10, MST1R
16	Asthma20	9.1	HLA-DRB1, TNF, HLA-DQB1, HLA-DQA1, IL10, RNASE3
17	Immune response IL-1 signaling pathway10	9.1	NOS2, IL6, EDN1, TNF, HMOX1, IL8
18	Immune response_IL-1 signaling pathway41	9.1	IL1B, NOS2, TNF, IL6, HMOX1, IL8
19	IL-10 Pathway36	9.1	CD14, IL1B, IL6, HMOX1, TNF, IL10
20	Pertussis20	9.0	IL8, NOS2, CD14, TNF, IL6, IL1B
21	MIF Mediated Glucocorticoid Regulation36	9.0	BTK, CD14, LTA, IL1B, IL10, IL8
22	MIF Regulation of Innate Immune Cells36	9.0	LTA, TNF, IL6, IL8, IL1B, IL10
23	Immune response MIF in innate immunity response10	9.0	TNF, IFNG, IL8, IL6, CD14, NOS2
24	Immune response_MIF in innate immunity response41	9.0	IFNG, TNF, NOS2, IL8, CD14, IL6
25	Autoimmune thyroid disease20	8.9	HLA-B, HLA-DQA1, HLA-DRB1, HLA-A, HLA-DQB1, IL10
26	Cytokine Network36	8.9	LTA, TNF, IL10, IL1B, IL8, IL6
27	Intestinal immune network for IgA production20	8.9	IL10, IL6, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNFRSF13B
28	Immune response_MIF-mediated glucocorticoid regulation41	8.8	IL6, MMP1, TNF, IFNG, IL8, ICAM1
29	Immune response MIF-mediated glucocorticoid regulation10	8.8	ICAM1, IL8, IL6, MMP1, NOS2, IFNG
30	Staphylococcus aureus infection20	8.8	ICAM1, IL10, HLA-DQB1, HLA-DRB1, HLA-DQA1, MBL2
31	Phagosome20	8.8	MPO, TAP2, TAP1, TLR2, HLA-DRB1, HLA-DQB1
32	African trypanosomiasis20	8.8	IFNG, ICAM1, IL10, IL1B, IL6, TNF
33	Chagas disease (American trypanosomiasis)20	8.7	IL6, IL8, IL10, IL1B, TNF, NOS2
34	STAT3 Pathway36	8.7	CXCR4, LTA, TNFRSF13B, IL8, IL6, IL1B
35	THC Differentiation Pathway36	8.6	IL10, IFNG, HLA-DRB1, HLA-DQA1, HLA-DQB1, TNF
36	Akt Signaling36	8.6	BTK, MST1R, CD4, LTA, IL6, TNF
37	Malaria20	8.5	TNF, ICAM1, TLR2, IL8, IL1B, IFNG
38	Hematopoietic cell lineage20	8.5	IL1B, CD36, CD14, TNF, CD4, HLA-DRB1
39	Systemic lupus erythematosus20	8.5	CTSG, TNF, HLA-DRB1, HLA-DQB1, IL10, HLA-DQA1
40	Tec Kinases Signaling36	8.4	IL6, IL1B, CD4, ITGAV, IL10, CXCR4
41	Allograft rejection20	8.4	HLA-A, HLA-DQA1, HLA-B, IFNG, IL10, HLA-DRB1
42	Type I diabetes mellitus20	8.3	HLA-DQB1, TNF, HLA-DRB1, HLA-DQA1, HLA-B, HLA-A
43	Antioxidant Action of Vitamin-C36	8.3	CXCR4, IL10, TNFRSF13B, LTA, IL8, IL6
44	Cytokine-cytokine receptor interaction20	8.3	IFNG, CXCR4, CXCR1, LTA, TNFRSF13B, TNF
45	Toxoplasmosis20	8.3	HLA-DQA1, TLR2, HLA-DQB1, NOS2, TNF, HLA-DRB1
46	Leishmaniasis20	8.2	TLR2, NOS2, HLA-DQA1, TNF, HLA-DQB1, IL10
47	Influenza A20	8.0	HLA-DRB1, IFNG, IL6, ICAM1, HLA-DQA1, TNF
48	Rheumatoid arthritis20	7.8	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, ICAM1, IL8
49	Tuberculosis20	7.6	HLA-DRB1, TLR2, NOS2, TNF, HLA-DQB1, CD14
50	Selected targets of GCR-alpha10	INF	IL6, TLR2, SCNN1A, , IL1B

Compounds related to bronchiectasis according to GeneDecks:

(show top 50)    (show all 270)

id	Compound	Score	Top Affiliating Genes
1	vegf32	INF	BPI, MST1, MPO, CD36, CD14, ITGAV
2	endotoxin32	10.3	BPI, CD14, CTSG, LTA, ELANE, CXCR1
3	budesonide32 42 9 9	13.3	IGHE, RNASE3, CD36
4	methacholine32 9 9	11.7	IGES, IGHE, ICAM1, CTSG, RNASE3, TTF2
5	pge232	9.6	CFTR, CD14, CD4, MMP1, MMP8, HMOX1
6	calcitriol32 42 9 18 9	13.1	CD36, CD14, MMP14, LTA, TLR2, SLPI
7	clodronate32 9 9	11.1	MMP14, IL10, IL1B, CD36, MMP8, IL6
8	fmlp32	8.9	ICAM1, SERPINA3, MPO, CD14, IL1B, IL8
9	fluticasone propionate32 42 9 9	11.8	MPO, MMP9, IL1B, IL8, IGHE, IFNG
10	leukotriene b432 42 18	10.8	SLPI, ELANE, RNASE3, CTSG, TNF, IL6
11	polyinosinic-polycytidylic acid32	8.7	TLR2, IL10, IL6, IL8, IFNG, HLA-B
12	taurine chloramine32	8.7	IFNG, MPO, IL1B, HMOX1, TNF, NOS2
13	lipoteichoic acid32	8.7	BPI, CD14, IL10, IL1B, IL6, IL8
14	polymyxin b32	8.5	MBL2, IFNG, ICAM1, TNF, TLR2, IL8
15	superoxide32 18	9.4	SERPINA3, SLPI, ADRB2, CXCR4, CXCR1, SERPINB1
16	gm-csf32	8.3	IL10, IFNG, ICAM1, TNF, ELANE, CD14
17	pentoxifylline32 9 9	10.1	MPO, CD14, MMP1, IL10, IL1B, IL6
18	8-isoprostane32	8.1	TNF, HMOX1, ICAM1, IL8, IL6, IL10
19	neopterin32	8.0	CD79A, CD14, CD4, IL10, IL1B, IL6
20	prednisolone32 9 9	9.9	IL10, IL6, MBL2, IGHE, IFNG, ALB
21	cysteine32	7.8	HMOX1, ALB, IFNG, MMP9, MMP8, MMP1
22	rantes32	7.8	SLPI, CXCR4, CD14, CD4, MMP1, MMP9
23	ccl332	7.8	CXCR1, CXCR4, MMP9, TLR2, TNF, ICAM1
24	sb 20358032 42	8.8	CD36, MMP9, BTK, MMP1, IL6, IFNG
25	oligonucleotide32	7.6	HLA-DQA1, SLPI, CXCR4, CXCR1, LTA, ADRB2
26	herbimycin a32 42	7.7	IL1B, IL6, IL8, IFNG, ICAM1, TNF
27	nitric oxide32 9 18 9	9.7	IL1B, IL6, IL8, MBL2, IGES, IFNG
28	cyclosporin a32 42	7.3	IL8, IGES, IGHE, IFNG, ICAM1, HMOX1
29	n acetylcysteine32	INF	IGHE, MMP9, MMP1, CFTR, RNASE3, CD79A
30	genistein32 9 18 9	INF	IFNG, ICAM1, TNF, NOS2, EDN1,
31	retinoic acid32 42 18	INF	RNASE3, CTSG, TNF, HLA-B, HMOX1, ICAM1
32	actinomycin d32	INF	IGHE, IFNG, ICAM1, HMOX1, TNF, NOS2
33	hyaluronic acid32 18	INF	ELANE, , SLPI, LTA, MMP1, CD36
34	serine32	INF	MMP1, MMP14, MMP8, MMP9, FCN2, IL8
35	indomethacin32 9 9	INF	IL1B, IL6, IGHE, IFNG, ALB, HMOX1
36	heparin32 9 18 9	INF	MPO, SLPI, CXCR4, TTF2, RNASE3, CTSG
37	h2o232	INF	, SERPINB1, CFTR, MPO, RNASE3, CTSG
38	ivig32	INF	BTK, LTA,
39	hydrocortisone32 9 9	INF	ELANE, SLPI, , TNF, IFNG, IGHE
40	paraffin32	INF	LTA, HLA-DQA1, HLA-B, MBL2, MMP9, MPO
41	alanine32	INF	SERPINA3, BPI, CFTR, CD79A, CD14, CD4
42	histamine32 18	INF	ALB, HMOX1, CTSG, RNASE3, EDN1,
43	creatinine32	INF	SERPINA1, SERPINA3, BPI, MPO, CD79A, CD14
44	dexamethasone32 42 34 9 9	INF	SERPINA3, SCNN1A, CFTR, CD79A, CD36, LTA
45	polysaccharide32	INF	CD79A, SERPINA1, FCN2, MBL2, SERPINA3, IGHE
46	fibrinogen32	INF	ICAM1, ALB, HLA-B, TNF, CTSG, RNASE3
47	vitamin d32	INF	SLPI, CD36, IGHE, ALB, LTA, ELANE
48	lactate32	INF	HLA-B, TNF, CTSG, RNASE3, LTA, ELANE
49	cycloheximide32	INF	LTA, TNF, SLPI, CXCR4, CXCR1, MMP9
50	(4-aminophenyl)mercuric acetate32	INF	ELANE, CTSG, MMP9, MMP8, MMP1, CD36

Cellular components related to bronchiectasis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	sodium channel complex	GO:034706	10.4	SCNN1A, SCNN1B, SCNN1G
2	axonemal dynein complex	GO:005858	10.0	DNAI2, DNAH9, DNAH11, DNAH1, DNAH5
3	cilium axoneme	GO:035085	9.7	DNAI2, DNAH9, DNAH11, DNAH1, DNAAF1, DNAI1
4	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.3	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A
5	ER to Golgi transport vesicle membrane	GO:012507	9.2	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A
6	membrane raft	GO:045121	9.1	TNF, CD4, CD14, CD36, CD79A, BTK
7	cell surface	GO:009986	8.9	CXCR4, TLR2, ELANE, CTSG, TNF, ITGAV
8	external side of plasma membrane	GO:009897	7.7	SCNN1A, CXCR4, TLR2, TNFRSF13B, TNF, HLA-DRB1
9	integral to plasma membrane	GO:005887	7.7	HLA-DQA1, HLA-DRB1, TNF, TNFRSF13B, PKD1, TLR2
10	extracellular region	GO:005576	7.6	MBL2, IFNG, ALB, CTSG, RNASE3, EDN1
11	extracellular space	GO:005615	INF	MBL2, IFNG, ICAM1, ALB, HMOX1, TNF
12	cytoplasm	GO:005737	INF	DNAH5, DNAAF3, DNAAF2, TLR2, TTF2, DNAI1

Biological processes related to bronchiectasis according to GeneDecks:

(show all 41)

id	Name	GO ID	Score	Top Affiliating Genes
1	flagellar cell motility	GO:060286	10.6	DNAAF2, CCDC39, CCDC40
2	cilium movement	GO:003341	10.6	DNAAF1, RSPH9, RSPH4A
3	ciliary cell motility	GO:060285	10.6	DNAAF2, CCDC39, CCDC40
4	cellular response to lipoteichoic acid	GO:071223	10.3	CD36, CD14, TLR2
5	acute-phase response	GO:006953	10.2	SERPINA1, SERPINA3, IL6, MBL2
6	excretion	GO:007588	10.2	HMOX1, SCNN1G, SCNN1B, SCNN1A
7	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	10.0	TAP2, TAP1, HLA-B, HLA-A, ITGAV, CD36
8	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	10.0	TAP2, TAP1, HLA-B, HLA-A, ITGAV, CD36
9	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	10.0	TAP2, TAP1, HLA-B, HLA-A, ITGAV, CD36
10	positive regulation of MAP kinase activity	GO:043406	9.9	ELANE, EDN1, TNF, MST1R
11	negative regulation of lipid storage	GO:010888	9.9	ITGAV, IL6, TNF
12	extracellular matrix disassembly	GO:022617	9.9	ELANE, CTSG, MMP9, MMP8, MMP14, MMP1
13	positive regulation of tumor necrosis factor production	GO:032760	9.8	TLR2, IFNG, CD14, CD36
14	positive regulation of cytokine secretion	GO:050715	9.8	TLR2, TNF, IL10, CD14
15	response to lipopolysaccharide	GO:032496	9.8	ELANE, EDN1, LTA, CTSG, MMP9, SERPINA1
16	calcium-mediated signaling	GO:019722	9.8	CXCR4, EDN1, TNF, IL8, BTK
17	axonemal dynein complex assembly	GO:070286	9.8	DNAAF1, DNAAF3, DNAAF2, CCDC39, CCDC40
18	neutrophil chemotaxis	GO:030593	9.8	IL1B, IL8, IFNG, EDN1
19	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.7	TNF, IFNG, IL1B
20	defense response to Gram-positive bacterium	GO:050830	9.7	TLR2, LTA, TNF, MBL2, IL6, CD36
21	cellular response to interleukin-1	GO:071347	9.7	EDN1, ICAM1, IL8, MMP9
22	positive regulation of interleukin-6 production	GO:032755	9.6	TLR2, TNF, IL6, IL1B, CD36
23	positive regulation of chemokine production	GO:032722	9.6	TNF, IL6, TLR2
24	positive regulation of smooth muscle cell proliferation	GO:048661	9.6	ELANE, EDN1, TNF, HMOX1, IL6
25	detection of bacterium	GO:016045	9.5	HLA-DRB1, HLA-B, HLA-A
26	positive regulation of chemokine biosynthetic process	GO:045080	9.4	TNF, HMOX1, IFNG, IL1B
27	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.4	IL1B, IFNG, TNF
28	negative regulation of interleukin-6 production	GO:032715	9.4	TNF, IL10, BPI
29	defense response to bacterium	GO:042742	9.4	RNASE3, NOS2, IFNG, IL10, BPI
30	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.3	TLR2, TNF, ICAM1, IL6, IL1B, BTK
31	humoral immune response	GO:006959	9.3	IL6, IFNG, TNF, LTA
32	cell surface receptor signaling pathway	GO:007166	9.3	ADRB2, CXCR1, EDN1, TNFRSF13B, IFNG, CD4
33	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	TLR2, EDN1, TNF, ICAM1, IFNG, IL1B
34	negative regulation of growth of symbiont in host	GO:044130	9.2	CD36, TLR2, ELANE, LTA, CTSG, TNF
35	cellular response to lipopolysaccharide	GO:071222	9.2	NOS2, ICAM1, IFNG, IL8, IL10, CD14
36	immune response	GO:006955	9.1	TLR2, CTSG, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B
37	inflammatory response	GO:006954	8.9	TNF, TLR2, CXCR1, CXCR4, IL8, IL6
38	response to hypoxia	GO:001666	8.8	CXCR4, EDN1, LTA, NOS2, TNF, IL1B
39	interferon-gamma-mediated signaling pathway	GO:060333	8.8	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A, ICAM1
40	cytokine-mediated signaling pathway	GO:019221	8.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A, ICAM1
41	extracellular matrix organization	GO:030198	INF	, ELANE, CTSG, TNF, MMP9, MMP8

Molecular functions related to bronchiectasis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	ADRB2, ICAM1, ALB, HLA-A, TNF, TNFRSF13B
2	ligand-gated sodium channel activity	GO:015280	10.3	SCNN1A, SCNN1B, SCNN1G
3	microtubule motor activity	GO:003777	9.5	DNAI2, DNAH9, DNAH11, DNAH1, DNAH5
4	MHC class II receptor activity	GO:032395	9.5	HLA-DQA1, HLA-DQB1, HLA-DRB1
5	cytokine activity	GO:005125	8.4	EDN1, LTA, TNF, IFNG, IL6, IL1B