MCID: BRN022
MIFTS: 50

Bronchiectasis malady

Categories: Respiratory diseases

Aliases & Classifications for Bronchiectasis

Aliases & Descriptions for Bronchiectasis:

Name: Bronchiectasis 12 52 42 14 69
Polynesian Bronchiectasis 12
Kartagener Syndrome 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9563
ICD10 33 J47 J47.9
ICD9CM 35 494
MeSH 42 D001987
NCIt 47 C84475
UMLS 69 C0006267

Summaries for Bronchiectasis

Disease Ontology : 12 A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

MalaCards based summary : Bronchiectasis, also known as polynesian bronchiectasis, is related to bronchiectasis with or without elevated sweat chloride 3 and pyelonephritis. An important gene associated with Bronchiectasis is CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), and among its related pathways/superpathways are Innate Immune System and Defensins. The drugs Azithromycin and Tobramycin have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and testes, and related phenotypes are hematopoietic system and immune system

Wikipedia : 71 Bronchiectasis is a disease in which there is permanent enlargement of parts of the airways of the lung.... more...

Related Diseases for Bronchiectasis

Diseases related to Bronchiectasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 259)
id Related Disease Score Top Affiliating Genes
1 bronchiectasis with or without elevated sweat chloride 3 33.5 CFTR SCNN1A SCNN1B
2 pyelonephritis 29.5 CFTR CXCL8 TNF
3 pericholangitis 29.1 MPO TLR2 TNF
4 bronchiectasis with or without elevated sweat chloride 1 12.1
5 bronchiectasis with or without elevated sweat chloride 2 12.1
6 idiopathic bronchiectasis 12.0
7 ciliary dyskinesia-bronchiectasis 11.9
8 bronchiectasis oligospermia 11.7
9 kartagener syndrome 11.6
10 ciliary dyskinesia, primary, 1, with or without situs inversus 11.3
11 cystic fibrosis 11.2
12 primary ciliary dyskinesia 11.1
13 yellow nail syndrome 11.1
14 nontuberculous mycobacterial lung disease 10.9
15 tracheobronchomegaly 10.9
16 ciliary dyskinesia, primary, 27 10.8
17 ciliary dyskinesia, primary, 26 10.8
18 ciliary dyskinesia, primary, 32 10.8
19 ciliary dyskinesia, primary, 25 10.8
20 ciliary dyskinesia, primary, 28 10.8
21 ciliary dyskinesia, primary, 30 10.7
22 panbronchiolitis, diffuse 10.7
23 ciliary dyskinesia, primary, 12 10.7
24 ciliary dyskinesia, primary, 11 10.7
25 cutis laxa, ad 10.7
26 young syndrome 10.7
27 ciliary dyskinesia, primary, 9, with or without situs inversus 10.7
28 ciliary dyskinesia, primary, 22 10.7
29 ciliary dyskinesia, primary, 23 10.7
30 ciliary dyskinesia, primary, 20 10.6
31 ciliary dyskinesia, primary, 2 10.6
32 ciliary dyskinesia, primary, 10 10.6
33 ciliary dyskinesia, primary, 24 10.6
34 bronchial disease 10.6
35 immunodeficiency 14 10.6
36 ciliary dyskinesia, primary, 18 10.6
37 ciliary dyskinesia, primary, 16 10.6
38 ciliary dyskinesia, primary, 6 10.6
39 cutis laxa, autosomal dominant 2 10.6
40 ciliary dyskinesia, primary, 3, with or without situs inversus 10.6
41 ciliary dyskinesia, primary, 7, with or without situs inversus 10.6
42 primary ciliary dyskinesia 34 10.6
43 ciliary dyskinesia, primary, 21 10.6
44 primary ciliary dyskinesia 33 10.6
45 ciliary dyskinesia, primary, 19 10.6
46 primary ciliary dyskinesia 35 10.6
47 ciliary dyskinesia, primary, 5 10.6
48 ciliary dyskinesia, primary, 13 10.6
49 ciliary dyskinesia, primary, 17 10.6
50 ciliary dyskinesia, primary, 14 10.6

Comorbidity relations with Bronchiectasis via Phenotypic Disease Network (PDN): (show all 20)


Agammaglobulinemia, X-Linked 1 Anxiety Disorder
Aspergillosis Bronchitis
Bronchopneumonia Chronic Pulmonary Heart Disease
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Heart Disease
Hypothyroidism Idiopathic Interstitial Pneumonia
Lung Abscess Mitral Valve Disease
Osteoporosis Postinflammatory Pulmonary Fibrosis
Protein-Energy Malnutrition Pulmonary Tuberculosis
Respiratory Failure Rheumatoid Arthritis

Graphical network of the top 20 diseases related to Bronchiectasis:



Diseases related to Bronchiectasis

Symptoms & Phenotypes for Bronchiectasis

MGI Mouse Phenotypes related to Bronchiectasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 CFTR CTSG DNAH5 DNAI1 ELANE MBL2
2 immune system MP:0005387 9.65 ELANE MBL2 MMP8 MPO TLR2 TNF
3 respiratory system MP:0005388 9.17 CFTR DNAH5 DNAI1 SCNN1A SCNN1B TLR2

Drugs & Therapeutics for Bronchiectasis

Drugs for Bronchiectasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 169)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 2,Phase 1 83905-01-5 55185 53477736 447043
2
Tobramycin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 32986-56-4 5496 36294
3
Theophylline Approved Phase 4 58-55-9 2153
4
Amikacin Approved, Vet_approved Phase 4,Phase 1,Phase 2 37517-28-5 37768
5
Budesonide Approved Phase 4 51333-22-3 63006 5281004
6
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
7
Meropenem Approved, Investigational Phase 4 119478-56-7 64778 441130
8
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
9
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
10
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
11 Neurotransmitter Agents Phase 4
12 Peripheral Nervous System Agents Phase 4,Phase 2
13 Vasodilator Agents Phase 4
14 Anti-Asthmatic Agents Phase 4,Phase 2
15 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Immunoglobulins Phase 4,Phase 3
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Protective Agents Phase 4,Phase 1
19 Respiratory System Agents Phase 4,Phase 2
20 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
21 Antibodies Phase 4,Phase 3
22 Autonomic Agents Phase 4,Phase 2
23 Bronchodilator Agents Phase 4,Phase 2
24 Antioxidants Phase 4
25
Salmeterol xinafoate Phase 4 94749-08-3 56801
26 Atorvastatin Calcium Phase 4 134523-03-8
27
Fluticasone Phase 4,Phase 2 90566-53-3, 80474-14-2 62924 22833648
28 glucocorticoids Phase 4
29 Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Phase 4
30 Adrenergic Agents Phase 4
31 Formoterol Fumarate Phase 4
32 Adrenergic Agonists Phase 4
33 Adrenergic beta-2 Receptor Agonists Phase 4
34 Adrenergic beta-Agonists Phase 4
35 Gentamicins Phase 4
36 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3
37 Dermatologic Agents Phase 4,Phase 2
38 Hormone Antagonists Phase 4
39 Hormones Phase 4
40 Vaccines Phase 4,Phase 3
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
42 Anti-Allergic Agents Phase 4,Phase 2
43 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
44 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
45 Phosphodiesterase Inhibitors Phase 4
46 Hypolipidemic Agents Phase 4
47 Expectorants Phase 4,Phase 2
48 Anticholesteremic Agents Phase 4
49 Antidotes Phase 4,Phase 1
50 Anti-Inflammatory Agents Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 214)
id Name Status NCT ID Phase
1 A Study to Access Safety and Efficacy of Nebulized Tobramycin in Patients With Bronchiectasis Unknown status NCT01677403 Phase 4
2 Salmeterol-Fluticasone Combined Inhaled Therapy for Non-cystic Fibrosis Bronchiectasis Completed NCT02782312 Phase 4
3 Is Regular Chest Physiotherapy an Effective Treatment in Severe, Non Cystic Fibrosis Bronchiectasis? Completed NCT00816309 Phase 4
4 The Role of Theophylline Plus Low-dose Formoterol-budesonide in Treatment of Bronchiectasis Completed NCT01769898 Phase 4
5 Efficacy of Azithromycin in Treatment of Bronchiectasis Completed NCT02107274 Phase 4
6 Atorvastatin in Bronchiectasis in Patients With Pseudomonas Aeruginosa Completed NCT01299194 Phase 4
7 The Effect of Theophylline in the Treatment of Bronchiectasis Completed NCT01684683 Phase 4
8 Pulmonary Rehabilitation in Non Cystic Fibrosis Bronchiectasis Completed NCT00868075 Phase 4
9 A Trial of Atorvastatin as an Anti-Inflammatory Agent in Non-Cystic Fibrosis Bronchiectasis Completed NCT01299181 Phase 4
10 Long Term Nebulised Gentamicin in Patients With Bronchiectasis Completed NCT00749866 Phase 4
11 Effectiveness and Safety of Inhaling Hypertonic Saline in Patients With Chronic Obstructive Pulmonary Disease Completed NCT00639236 Phase 4
12 Efficacy of Temporary Positive Expiratory Pressure (TPEP) in Chronic Hypersecretion Completed NCT00700388 Phase 4
13 Bacterial Load Guided Therapy for Severe Bronchiectasis Exacerbations Recruiting NCT02047773 Phase 4
14 Vitamin D as an Adjunctive Treatment in Patients With Non-Cystic Fibrosis Bronchiectasis Recruiting NCT02507843 Phase 4
15 Therapy of Bronchoalveolar Lavage and Local Amikacin Injection in Patients With Acute Exacerbation of Bronchiectasis Recruiting NCT02509091 Phase 4
16 Comparisons of Inhaled LAMA or ICS+LABA for COPD With Bronchiectasis Recruiting NCT02546297 Phase 4
17 Evaluating the Effects of Traditional Chinese Medicine by N-of-1 Trials Recruiting NCT03147443 Phase 4
18 Hospitalised Pneumonia With Extended Treatment (HOPE) Study Recruiting NCT02783859 Phase 4
19 Polysaccharide Antibody Response Study Recruiting NCT02429531 Phase 4
20 Combined Administration of Nebulized Amikacin in Patients With Acute Exacerbation of Non-Cystic Fibrosis Bronchiectasis Active, not recruiting NCT02081963 Phase 4
21 Effect of Long-term, High-dose N-acetylcysteine on Exacerbations of Bronchiectaisis Active, not recruiting NCT02088216 Phase 4
22 Use of Roflumilast to Prevent Exacerbations in Fibrotic Sarcoidosis Patients (REFS) Active, not recruiting NCT01830959 Phase 4
23 Oscillating PEP vs Autogenic Drainage in People With Bronchiectasis Not yet recruiting NCT03013452 Phase 4
24 Bronchiectasis and Long Term Azithromycin Treatment Unknown status NCT00415350 Phase 3
25 The Role of Inhalations of Tranexamic Acid in Patients With Hemoptysis Unknown status NCT01496196 Phase 3
26 Phase 3 Study With Dual Release Ciprofloxacin for Inhalation in Non-CF Bronchiectasis Completed NCT02104245 Phase 3
27 Ciprofloxacin Dry Powder for Inhalation in Non-cystic Fibrosis Bronchiectasis (Non-CF BE) Completed NCT01764841 Phase 3
28 Ciprofloxacin Dry Powder for Inhalation (DPI) in Non-cystic Fibrosis Bronchiectasis (Non-CF BE) Completed NCT02106832 Phase 3
29 Inhaled Mannitol as a Mucoactive Therapy for Bronchiectasis Completed NCT00669331 Phase 3
30 Safety and Efficacy of Bronchitol in Bronchiectasis Completed NCT00277537 Phase 3
31 The Long Term Effect of Inhaled Hypertonic Saline (6%) in Patients With Non Cystic Fibrosis Bronchiectasis Completed NCT00484263 Phase 3
32 Safety and Effectiveness of AZLI (an Inhaled Antibiotic) in Adults With Non-Cystic Fibrosis Bronchiectasis Completed NCT01313624 Phase 3
33 Safety and Effectiveness of AZLI (an Inhaled Antibiotic) in Adults With Non-Cystic Fibrosis Bronchiectasis Completed NCT01314716 Phase 3
34 Phase 3 Study With Dual Release Ciprofloxacin for Inhalation in Non-CF Bronchiectasis Completed NCT01515007 Phase 3
35 Efficacy and Safety Study of a Percussion Device to Mobilise Sputum From Respiratory Passage Completed NCT01480882 Phase 2, Phase 3
36 Conjugate Pneumococcal Vaccine in Ataxia Telangiectasia (AT) Completed NCT00656409 Phase 3
37 EZ-2053 in the Prophylaxis of Acute Pulmonary Allograft Rejection Completed NCT00105183 Phase 3
38 Therapeutic Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of AG1321001 in Chronic Cougher Completed NCT00380315 Phase 3
39 Phase 3 Study of Aztreonam for Inhalation Solution (AZLI) in a Continuous Alternating Therapy Regimen for the Treatment of Chronic Pseudomonas Aeruginosa Infection in Patients With CF Completed NCT01641822 Phase 3
40 Prevention of OM-85 on Bronchiectasis Exacerbation Recruiting NCT01968421 Phase 3
41 Prevention of Bronchiectasis in Infants With Cystic Fibrosis Recruiting NCT01270074 Phase 3
42 Trial in Non-cystic Fibrosis Bronchiectasis Patients With Chronic Lung Infections Treated With Colistimethate Sodium Recruiting NCT03093974 Phase 3
43 An Open Label Trial of Azithromycin in Chronic Productive Cough Recruiting NCT02196493 Phase 3
44 Effects of Roflumilast in Hospitalized Chronic Obstructive Pulmonary Disease( COPD) on Mortality and Re-hospitalization Recruiting NCT01973998 Phase 3
45 The Efficacy of Azithromycin in Treating Children With Non Cystic Fibrosis Bronchiectasis Active, not recruiting NCT02531984 Phase 3
46 Inhaled Nebulized Tobramycin in Non-cystic Fibrosis Bronchiectasis Enrolling by invitation NCT02657473 Phase 2, Phase 3
47 Hypertonic Saline (6%) Versus Isotonic Saline (0.9%) in Bronchiectasis Unknown status NCT01112410 Phase 2
48 Phase2, Single Group, Open Clinical Trial to Evaluate the Efficacy and Safety of Roflumilast in Symptomatic Bronchiectasis Patients Unknown status NCT01580748 Phase 2
49 Pharmacokinetic Evaluation and Tolerability of Dry Powder Tobramycin by a Novel Device in Patients With Non Cystic Fibrosis Bronchiectasis Completed NCT02035488 Phase 1, Phase 2
50 Physical Capacity in Patients With Bronchiectasis Before and After Rehabilitation Program Completed NCT02208830 Phase 1, Phase 2

Search NIH Clinical Center for Bronchiectasis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: bronchiectasis

Genetic Tests for Bronchiectasis

Anatomical Context for Bronchiectasis

MalaCards organs/tissues related to Bronchiectasis:

39
Lung, Neutrophil, Testes, Colon, Thyroid, Bone, Kidney

Publications for Bronchiectasis

Articles related to Bronchiectasis:

(show top 50) (show all 763)
id Title Authors Year
1
Microbial Dysbiosis in Bronchiectasis and Cystic Fibrosis. ( 28069292 )
2017
2
Comparing accelerometer, pedometer and a questionnaire for measuring physical activity in bronchiectasis: a validity and feasibility study? ( 28088206 )
2017
3
Serum Albumin and Disease Severity of Non-Cystic Fibrosis Bronchiectasis. ( 28512120 )
2017
4
Diagnosis of bronchiectasis and airway wall thickening in children with cystic fibrosis: Objective airway-artery quantification. ( 28523349 )
2017
5
Sugar coating bronchiectasis. ( 28070016 )
2017
6
Aspergillus Species in Bronchiectasis: Challenges in the Cystic Fibrosis and Non-cystic Fibrosis Airways. ( 28516246 )
2017
7
Diffuse bronchiectasis as the primary manifestation of endobronchial sarcoidosis. ( 27896060 )
2017
8
Two cases of non-cystic fibrosis (CF) bronchiectasis with allergic bronchopulmonary aspergillosis. ( 28053855 )
2017
9
Bronchiectasis and the risk of cardiovascular disease: a population-based study. ( 27573451 )
2016
10
High prevalence of bronchiectasis in patients with cartilage-hair hypoplasia. ( 27568079 )
2016
11
FUT2 genotype influences lung function, exacerbation frequency and airway microbiota in non-CF bronchiectasis. ( 27503233 )
2016
12
The factors affecting survival in patients with bronchiectasis. ( 28081336 )
2016
13
The development of bronchiectasis on chest computed tomography in children with cystic fibrosis: can pre-stages be identified? ( 27108295 )
2016
14
Prevalence and incidence of bronchiectasis in Catalonia, Spain: A population-based study. ( 27888988 )
2016
15
Tracheobronchomegaly as a Cause of Bronchiectasis in an Adult. ( 27022496 )
2016
16
Giant Aortopulmonary Collateral Artery in an Adult with Bronchiectasis. ( 27127447 )
2016
17
Clinical characteristics of pulmonary hypertension in bronchiectasis. ( 27527360 )
2016
18
The Importance of Phenotyping Bronchiectasis. ( 27592362 )
2016
19
Quality standards for the management of bronchiectasis in Italy: a national audit. ( 27076581 )
2016
20
Adult Bronchiectasis Patients: A First Look at the United States Bronchiectasis Research Registry. ( 27889361 )
2016
21
Importance of fractional exhaled nitric oxide in diagnosis of bronchiectasis accompanied with bronchial asthma. ( 27162676 )
2016
22
Telomere Dysfunction and Senescence-associated Pathways in Bronchiectasis. ( 27082536 )
2016
23
Changing epidemiology of non-cystic fibrosis bronchiectasis. ( 27922232 )
2016
24
Neutrophil Fates in Bronchiectasis and Alpha-1 Antitrypsin Deficiency. ( 27115946 )
2016
25
Multidimensional severity assessment in bronchiectasis: an analysis of seven European cohorts. ( 27516225 )
2016
26
Unsupervised learning technique identifies bronchiectasis phenotypes with distinct clinical characteristics. ( 27046724 )
2016
27
Neutrophil Elastase Activity is Associated with Exacerbations and Lung Function Decline in Bronchiectasis. ( 27911604 )
2016
28
Genesis of the Nodular Bronchiectasis Phenotype of Pulmonary Disease Due to Nontuberculous Mycobacteria. ( 27055711 )
2016
29
Bronchiectasis as a Comorbidity of Chronic Obstructive Pulmonary Disease: Implications and Future Research. ( 27569224 )
2016
30
Cystic Bronchiectasis Imitating Pulmonary Aspergilloma. ( 27569246 )
2016
31
In Reply: Towards precision medicine: phenotyping bronchiectasis with unsupervised learning technique. ( 27084831 )
2016
32
Quantitative CT measures of bronchiectasis in smokers. ( 27890712 )
2016
33
Unusual cause of localised bronchiectasis. ( 27516226 )
2016
34
Prevalence and factors associated with nontuberculous mycobacteria in non-cystic fibrosis bronchiectasis: a multicenter observational study. ( 27549788 )
2016
35
Evaluation of a novel information resource for patients with bronchiectasis: study protocol for a randomised controlled trial. ( 27107959 )
2016
36
ERJ September Podcast: research priorities in bronchiectasis. ( 27581418 )
2016
37
Phenotyping bronchiectasis: is it all about sputum and infection? ( 27037310 )
2016
38
Asthma and bronchiectasis exacerbation. ( 27076584 )
2016
39
Video-assisted thoracoscopic segmentectomy of lingual segment of the left upper pulmonary lobe for chronic focal bronchiectasis. ( 27076962 )
2016
40
Time Trends in Hospital Admissions for Bronchiectasis: Analysis of the Spanish National Hospital Discharge Data (2004 to 2013). ( 27622273 )
2016
41
Macrolides for Clinically Significant Bronchiectasis in Adults: Who Should Receive this Treatment? ( 27591924 )
2016
42
Enlarged Dural Sac in Idiopathic Bronchiectasis Implicates Heritable Connective Tissue Gene Variants. ( 27409985 )
2016
43
Challenges in managing Pseudomonas aeruginosa in non-cystic fibrosis bronchiectasis. ( 27492530 )
2016
44
Primary ciliary dyskinesia in six patients with bronchiectasis. ( 27238169 )
2016
45
Impulse Oscillometry and Spirometry Small-Airway Parameters in Mild to Moderate Bronchiectasis. ( 27484107 )
2016
46
Left middle lobectomy for bronchiectasis in a patient with Kartagener syndrome: a case report. ( 26960394 )
2016
47
Bronchiectasis in 2016: advances in our understanding. ( 27890499 )
2016
48
Factors related to depression and anxiety in adults with bronchiectasis. ( 27920537 )
2016
49
Risk factors for requiring intravenous antibiotic therapy in hospital and 30-day readmission for exacerbations of bronchiectasis. ( 27081209 )
2016
50
Surgery for predominant lesion in nonlocalized bronchiectasis. ( 28073573 )
2016

Variations for Bronchiectasis

Expression for Bronchiectasis

Search GEO for disease gene expression data for Bronchiectasis.

Pathways for Bronchiectasis

Pathways related to Bronchiectasis according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 BPI CTSG CXCL8 ELANE MBL2 MMP8
2
Show member pathways
12.18 BPI CTSG ELANE TLR2
3
Show member pathways
12.13 CFTR CXCL8 TLR2 TNF
4
Show member pathways
11.84 CFTR CXCL8 TLR2 TNF
5 11.65 CXCL8 TLR2 TNF
6 11.45 CXCL8 SERPINA1 TNF
7
Show member pathways
11.45 CTSG ELANE MMP8 TNF
8 11.37 CXCL8 TLR2 TNF
9 11.27 CXCL8 TLR2 TNF
10 11.24 CTSG CXCL8 TLR2 TNF
11 11.23 ELANE MPO TNF
12 10.98 CFTR SCNN1A SCNN1B
13 10.83 CXCL8 TNF
14 10.74 MPO TNF
15 9.91 CFTR SCNN1A SCNN1B

GO Terms for Bronchiectasis

Cellular components related to Bronchiectasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 BPI CTSG CXCL8 ELANE MBL2 MMP8
2 cell surface GO:0009986 9.73 CFTR CTSG ELANE MBL2 TLR2 TNF
3 extracellular space GO:0005615 9.65 BPI CTSG CXCL8 ELANE MBL2 MMP8
4 secretory granule GO:0030141 9.61 CTSG ELANE MPO
5 specific granule lumen GO:0035580 9.54 BPI ELANE MMP8
6 sodium channel complex GO:0034706 9.4 SCNN1A SCNN1B
7 outer dynein arm GO:0036157 9.32 DNAH5 DNAI1
8 azurophil granule lumen GO:0035578 9.02 BPI CTSG ELANE MPO SERPINA3
9 extracellular exosome GO:0070062 10.11 BPI CFTR CTSG ELANE MPO SCNN1A

Biological processes related to Bronchiectasis according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 BPI CTSG CXCL8 TLR2 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.77 CTSG CXCL8 TNF
3 response to lipopolysaccharide GO:0032496 9.76 CTSG ELANE MPO TLR2
4 extracellular matrix disassembly GO:0022617 9.7 CTSG ELANE MMP8
5 defense response to bacterium GO:0042742 9.63 BPI CTSG ELANE MBL2 MPO TNF
6 defense response to Gram-positive bacterium GO:0050830 9.62 CTSG MBL2 TLR2 TNF
7 antimicrobial humoral response GO:0019730 9.61 BPI CTSG ELANE
8 positive regulation of NF-kappaB import into nucleus GO:0042346 9.6 TLR2 TNF
9 embryonic digestive tract development GO:0048566 9.58 CXCL8 TNF
10 positive regulation of chemokine production GO:0032722 9.58 TLR2 TNF
11 acute-phase response GO:0006953 9.58 MBL2 SERPINA1 SERPINA3
12 outer dynein arm assembly GO:0036158 9.57 DNAH5 DNAI1
13 response to molecule of bacterial origin GO:0002237 9.56 CXCL8 TLR2
14 neutrophil degranulation GO:0043312 9.56 BPI CTSG ELANE MMP8 MPO SERPINA1
15 sodium ion homeostasis GO:0055078 9.55 SCNN1A SCNN1B
16 positive regulation of immune response GO:0050778 9.54 CTSG ELANE
17 defense response to fungus GO:0050832 9.54 CTSG ELANE MPO
18 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.49 ELANE TNF
19 response to yeast GO:0001878 9.48 ELANE MPO
20 multicellular organismal water homeostasis GO:0050891 9.43 CFTR SCNN1A SCNN1B
21 negative regulation of growth of symbiont in host GO:0044130 9.02 CTSG ELANE MBL2 MPO TNF

Molecular functions related to Bronchiectasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 ELANE SERPINA1 TNF
2 serine-type endopeptidase activity GO:0004252 9.26 CTSG ELANE MBL2 MMP8
3 ligand-gated sodium channel activity GO:0015280 8.62 SCNN1A SCNN1B

Sources for Bronchiectasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....