Aliases & Classifications for Bronchiolitis

MalaCards integrated aliases for Bronchiolitis:

Name: Bronchiolitis 12 51 3 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2942
MeSH 41 D001988
NCIt 46 C39658
SNOMED-CT 64 4120002
UMLS 69 C0006271

Summaries for Bronchiolitis

CDC : 3 Respiratory syncytial (sin-SISH-uhl) virus, or RSV, is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover in a week or two, but RSV can be serious, especially for infants and older adults. In fact, RSV is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia (infection of the lungs) in children younger than 1 year of age in the United States. It is also a significant cause of respiratory illness in older adults.

MalaCards based summary : Bronchiolitis is related to bronchiolitis obliterans and bronchitis, and has symptoms including cough, wheezing and shortness of breath. An important gene associated with Bronchiolitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bromhexine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and skin, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.

Wikipedia : 72 Bronchiolitis is blockage of the small airway in the lungs due to a viral infection. It usually only... more...

Related Diseases for Bronchiolitis

Diseases related to Bronchiolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 452)
# Related Disease Score Top Affiliating Genes
1 bronchiolitis obliterans 34.2 CXCL8 IFNG IL10 IL6 TNF
2 bronchitis 31.9 CCL11 CXCL8 IL5 RNASE3 TNF
3 extrinsic allergic alveolitis 31.7 CCL5 CXCL8 IL10 IL6
4 respiratory syncytial virus infectious disease 31.7 CCL3 CCL5 IL13 IL5
5 hematopoietic stem cell transplantation 31.1 IFNG IL10 IL6 TNF
6 graft-versus-host disease 30.6 IFNG IL10 IL6 TNF
7 arthritis 30.3 CXCL8 IFNG IL10 IL6 TNF
8 acute respiratory distress syndrome 30.2 CXCL8 IL6 TNF
9 mycoplasmal pneumonia 30.1 IFNG IL4
10 hyperlucent lung 30.0 IFNG IL10 IL4
11 pulmonary disease, chronic obstructive 30.0 CXCL8 IL6 RNASE3 TNF
12 ulcerative colitis 29.9 CXCL8 IFNG IL10 IL6 TLR4 TNF
13 pulmonary edema 29.9 CXCL8 IL10 TNF
14 mycobacterium abscessus 29.9 CXCL8 TLR1 TNF
15 interstitial lung disease 29.9 CCL5 CXCL8 IFNG IL10 IL4 IL6
16 rheumatic disease 29.9 IFNG IL10 TNF
17 pulmonary sarcoidosis 29.8 CCL5 IFNG TNF
18 temporal arteritis 29.8 CCL5 IFNG IL6
19 acute graft versus host disease 29.8 IFNG IL10 IL4 TNF
20 plasmodium vivax malaria 29.8 IFNG IL10 IL6 TNF
21 adult respiratory distress syndrome 29.8 CXCL8 IL10 IL6 TNF
22 bronchial disease 29.7 CCL11 CCL5 CXCL8 IL10 IL13 IL4
23 myasthenia gravis 29.7 IFNG IL10 IL4 TNF
24 synovitis 29.7 CXCL8 IL6 TNF
25 cystitis 29.7 CXCL8 IL6 TLR4 TNF
26 chronic eosinophilic pneumonia 29.7 CCL11 CCL5 IL5 IL6 RNASE3
27 cryptococcosis 29.7 IFNG IL4 TLR9
28 pertussis 29.7 IL10 IL6 TLR4 TNF
29 eosinophilic pneumonia 29.6 CCL11 CCL5 IL13 IL5 RNASE3
30 cytomegalovirus infection 29.6 CXCL8 IFNG IL10 IL6 TNF
31 wegener granulomatosis 29.6 CXCL8 IFNG IL10 IL6 TNF
32 chlamydia 29.6 CXCL8 IFNG IL10 IL6 TLR4 TNF
33 connective tissue disease 29.3 IFNG IL10 IL6 TLR9 TNF
34 common variable immunodeficiency 29.3 IFNG IL10 IL4 IL6 TLR9 TNF
35 colitis 29.2 CXCL8 IFNG IL10 IL4 IL6 TLR4
36 acquired immunodeficiency syndrome 29.2 CCL3 IFNG IL10 IL6 TNF
37 systemic lupus erythematosus 29.2 CCL5 IFNG IL10 IL4 IL6 TLR4
38 myeloma, multiple 29.1 CCL3 CXCL8 IL6 TLR9
39 mycobacterium tuberculosis 1 29.1 IFNG IL10 IL4 TLR1 TLR4 TLR9
40 idiopathic interstitial pneumonia 29.0 CXCL8 IFNG IL13 IL4 MUC5B TLR9
41 lung disease 29.0 CCL3 CCL5 CXCL8 IL10 IL13 IL5
42 rheumatoid arthritis 28.9 CCL3 CCL5 CXCL8 IFNG IL10 IL4
43 aspergillosis 28.9 IFNG IL10 IL4 IL5 TLR4 TLR9
44 pulmonary eosinophilia 28.9 CCL11 CCL5 IL13 IL4 IL5 RNASE3
45 bone inflammation disease 28.9 CXCL8 IFNG IL10 IL4 IL6 TLR9
46 pneumonia 28.8 CCL11 CCL3 CCL5 CXCL8 IL10 IL13
47 pulmonary tuberculosis 28.8 CCL3 IFNG IL10 IL4 TLR9 TNF
48 melioidosis 28.6 IFNG IL10 IL6 TLR1 TLR10 TLR4
49 common cold 28.5 CCL11 CCL5 CXCL8 IL13 IL5 RNASE3
50 gastroenteritis 28.3 CCL11 CXCL8 IFNG IL10 IL4 IL5

Graphical network of the top 20 diseases related to Bronchiolitis:



Diseases related to Bronchiolitis

Symptoms & Phenotypes for Bronchiolitis

Symptoms:

12
  • cough
  • wheezing
  • shortness of breath
  • fever
  • nasal flaring in infants
  • bluish skin due to lack of oxygen

MGI Mouse Phenotypes related to Bronchiolitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 CCL11 CCL5 IFNG IL10 IL13 IL4
2 digestive/alimentary MP:0005381 10.02 IFNG IL10 IL13 IL4 IL4R IL5
3 immune system MP:0005387 10 IL10 IL13 IL4 IL4R IL5 IL6
4 liver/biliary system MP:0005370 9.56 IFNG IL10 IL4 IL4R IL5 IL6
5 respiratory system MP:0005388 9.36 CCL11 IFNG IL10 IL13 IL4 IL4R

Drugs & Therapeutics for Bronchiolitis

Drugs for Bronchiolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 222)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bromhexine Approved Phase 4 3572-43-8
2
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
3 Racepinephrine Approved Phase 4,Phase 3,Phase 2 329-65-7
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
8
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
9
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
10
Mechlorethamine Approved, Investigational Phase 4,Phase 3,Phase 2 51-75-2 4033
11
Azithromycin Approved Phase 4,Phase 2,Phase 3,Phase 1 83905-01-5 53477736 447043 55185
12
Aztreonam Approved Phase 4 78110-38-0 5742832 5362041
13
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
14
Azathioprine Approved Phase 4 446-86-6 2265
15
Everolimus Approved Phase 4,Phase 3,Phase 1,Phase 2 159351-69-6 6442177
16
Prednisone Approved, Vet_approved Phase 4,Phase 1,Phase 2 53-03-2 5865
17
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 53123-88-9 46835353 6436030 5284616
18
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 104987-11-3 445643 439492
19
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
20
Macitentan Approved Phase 4 441798-33-0
21
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 67-97-0 10883523 5280795 6221
22
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
23
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
24 Epinephryl borate Phase 4,Phase 3,Phase 2
25 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
26 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
27 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
28 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1
29 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Mydriatics Phase 4,Phase 3,Phase 2
33 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
37 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
38 Ergocalciferols Phase 4,Phase 3,Phase 2
39 Micronutrients Phase 4,Phase 3,Phase 2
40 Trace Elements Phase 4,Phase 3,Phase 2
41 Vitamins Phase 4,Phase 3,Phase 2
42 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
43 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
45 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1
46 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
47 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
48 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
49 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
50 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 292)

# Name Status NCT ID Phase Drugs
1 Home Oxygen Therapy in Bronchiolitis Unknown status NCT01216553 Phase 4
2 Bronchiolitis All-study, SE-Norway Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
3 Effect of Vitamin D Supplementation in Young South African Children Hospitalized With Acute Lower Respiratory Infection Unknown status NCT02054182 Phase 4 Vitamin D
4 Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion Unknown status NCT01353105 Phase 4
5 Nebulized 5% Hypertonic Saline for the Treatment of Bronchiolitis Completed NCT01016249 Phase 4 Treatment 1. (5% Hypertonic saline + Epinephrine);Treatment 3. (3% Hypertonic saline + Epinephrine);Treatment 2. (Normal saline + Epinephrine)
6 Epinephrine, Dexamethasone, and Hypertonic Saline in Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety Completed NCT01834820 Phase 4 Epinephrine and Dexamethasone;Hypertonic Saline;Normal Saline
7 Glucocorticoid Therapy Impact on the Inflammatory Response and Clinical Evolution in Patients With Severe Bronchiolitis Completed NCT02571517 Phase 4 Glucocorticoids
8 7% Hypertonic Saline for Acute Bronchiolitis Completed NCT01871857 Phase 4 Hypertonic saline and epinephrine;Normal saline and epinephrine
9 Effectiveness of Nebulized Hypertonic Saline and Epinephrine in Hospitalized Infants With Bronchiolitis Completed NCT01300325 Phase 4
10 Efficacy of Nebulised Hypertonic Saline (3%) Among Children With Bronchiolitis. Completed NCT01276821 Phase 4 L-Epinephrine and Normal Saline (0.9%);L-Epinephrine and Hypertonic Saline (3%)
11 Hypertonic Saline for Acute Bronchiolitis Completed NCT01247064 Phase 4 Nebulized 3% saline;Nebulized 0.9% Normal Saline
12 Bronchodilator Responsiveness in Obliterative Bronchiolitis Completed NCT01112241 Phase 4 albuterol plus tiotropium
13 Efficacy and Safety of 3% Hypertonic Saline Inhalation (24h vs 72h) to Treat Acute Bronchiolitis in Hospitalized Infants Completed NCT02538458 Phase 4 3 % hypertonic saline up to 72H;3 % hypertonic saline up to 24H
14 Nebulized 3% Hypertonic Saline Solution Treatment of Bronchiolitis in Infants Completed NCT02233985 Phase 4 0.9% Sodium Chloride;3% Sodium Chloride
15 Impact of Oximetry on Hospitalization in Acute Bronchiolitis Completed NCT00673946 Phase 4
16 Vitamin D in Bronchiolitis Obliterans Syndrome Completed NCT01212406 Phase 4 Vitamin D
17 Montelukast in Bronchiolitis Obliterans Syndrome Completed NCT01211509 Phase 4 Montelukast
18 Use of Erythromycin in Mustard-Induced Bronchiolitis Completed NCT00367419 Phase 4 Erythromycin
19 The Effectiveness of Oral Dexamethasone for Acute Bronchiolitis Completed NCT00119002 Phase 4 dexamethasone;Placebo
20 Azithromycin in Bronchiolitis Obliterans Syndrome Completed NCT01009619 Phase 4 Azithromycin;Placebo
21 Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation Completed NCT01109160 Phase 4 Azithromycin Dihydrate
22 Safety Study of Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS) Completed NCT01469364 Phase 4 Aztreonam Lysine for Inhalation (AZLI)
23 Chronic Bronchiolitis or Resistant Asthma? Completed NCT00368342 Phase 4 Erythromycin, Azithromycin , Clarithromycin
24 Effect of Addition Oral Montelukast to Standard Treatment in Acute Asthma in Hospitalized Preschool Children Completed NCT03369119 Phase 4 Montelukast 4 Mg Oral Granule;Placebos
25 Comparison of Sirolimus and Azathioprine in Lung Transplantation Completed NCT00321906 Phase 4 azathioprine;sirolimus
26 High Flow Nasal Cannula vs Low Flow Oxygen Therapy in Bronchiolitis Recruiting NCT03015051 Phase 4 Oxygen
27 Comparison of High Flow Oxygenation Therapy and CPAP in Children With Bronchiolitis. Recruiting NCT02618213 Phase 4
28 Efficacy of Intermittent Tiotropium in Early Childhood Wheezing Recruiting NCT03199976 Phase 4 Tiotropium Bromide;Fluticasone Propionate;Salbutamol
29 Assessment of Thoracic Echography for Pleuroparenchymatous Anomaly Diagnosis Complicating Bronchiolitis: BronchioIUS Not yet recruiting NCT02890797 Phase 4
30 "Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use: A Randomized Controlled Trial" Inpatient Hospital Use: A Randomized Controlled Trial" Not yet recruiting NCT03364218 Phase 4 N acetyl cysteine nebulized
31 Macitentan in the Treatment of Organ Rejection After Lung Transplantation Not yet recruiting NCT02893176 Phase 4 macitentan;placebo (for macitentan)
32 Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study Terminated NCT00361452 Phase 4 nebulized epinephrine and nebulized albuterol
33 Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department Withdrawn NCT01660867 Phase 4 3% saline + oral placebo;0.9% saline + oral dexamethasone
34 Heliox-Driven Racemic Epinephrine Nebulization in Treatment of Moderate to Severe Bronchiolitis in Pediatric ED Patients Completed NCT00116584 Phase 3 heliox
35 Nasal Irrigation in Infants With Bronchiolitis. Completed NCT02162745 Phase 3 Isotonic solution (NaCl 0.9%);Hypertonic solution (NaCl 3%)
36 An Investigational Drug Study to Treat Respiratory Symptoms Associated With Respiratory Syncytial Virus (RSV) Bronchiolitis (0476-272) Completed NCT00076973 Phase 3 montelukast sodium;Comparator: placebo
37 "Palivizumab Therapy for RSV-bronchiolitis" Completed NCT02442427 Phase 3 Palivizumab
38 Nebulized Hypertonic Saline for Bronchiolitis Completed NCT00619918 Phase 2, Phase 3 Nebulized 3% saline;Placebo
39 The SABRE Trial of Hypertonic Saline in Acute Bronchiolitis Completed NCT01469845 Phase 3
40 Safety Study of Home Oxygen Therapy for Children With Acute Bronchiolitis Completed NCT00677066 Phase 3
41 High Flow Therapy vs Hypertonic Saline in Bronchiolitis Completed NCT01873144 Phase 3 Epinephrine 1/1000;HSS 3%;NS (0.9%)
42 Moderate to Severe Bronchiolitis: Standard Therapy Versus Therapy With NaCl 3% Inhalations Completed NCT01812525 Phase 3 NaCl 3%
43 Single Dose Versus Multiple Doses of Dexamethasone in Children With Acute Bronchiolitis Completed NCT00213226 Phase 3 dexamethasone
44 Efficacy of Zinc in the Treatment of Bronchiolitis and Prevention of Wheezing Respiratory Illness in Children Less Than Two Years Old Completed NCT00355043 Phase 3 Zinc sulphate 20 mg
45 Effect of Heliox on RSV Bronchiolitis Completed NCT03171142 Phase 3 Heliox;Air
46 Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis Completed NCT01777347 Phase 3 3% Saline;0.9% Normal Saline
47 The Use of an Inhaled Salt Solution to Treat Viral Lung Infections in Infants. Completed NCT00151905 Phase 2, Phase 3 3 % hypertonic saline
48 Tacrolimus Versus Cyclosporine for Immunosuppression After Lung Transplantation Completed NCT01429844 Phase 3 Tacrolimus;Cyclosporine
49 Study of Cyclosporine Inhalation Solution (CIS) in Improving Bronchiolitis Obliterans Syndrome-Free Survival Following Lung Transplantation Completed NCT00755781 Phase 3 Cyclosporine Inhalation Solution (CIS)
50 Use of Clarithromycin in Mustard-Induced Bronchiolitis Completed NCT00381147 Phase 3 Clarithromycin

Search NIH Clinical Center for Bronchiolitis

Cochrane evidence based reviews: bronchiolitis

Genetic Tests for Bronchiolitis

Anatomical Context for Bronchiolitis

MalaCards organs/tissues related to Bronchiolitis:

38
Lung, Bone, Skin, Bone Marrow, Breast, T Cells, Heart

Publications for Bronchiolitis

Articles related to Bronchiolitis:

(show top 50) (show all 1504)
# Title Authors Year
1
Nebulized hypertonic saline in infants hospitalized with moderately severe bronchiolitis due to RSV infection: A multicenter randomized controlled trial. ( 29327810 )
2018
2
Effectiveness of Respiratory Syncytial Virus Immunoprophylaxis on Bronchiolitis Hospitalizations among High-risk Infants. ( 29351636 )
2018
3
Bronchiolitis obliterans organizing pneumonia after stereotactic ablative radiation therapy for lung cancer: A case report. ( 29395853 )
2018
4
Outcomes of Follow-up Visits After Bronchiolitis Hospitalizations. ( 29379947 )
2018
5
Bronchiolitis Obliterans and Pulmonary Fibrosis After Sulfur Mustard Inhalation in Rats. ( 29314868 )
2018
6
Transaminase levels reflect disease severity in children ventilated for respiratory syncytial virus (RSV) bronchiolitis. ( 29379110 )
2018
7
Tocilizumab Cannot Prevent the Development of Bronchiolitis Obliterans in Patients With Castleman Disease-Associated Paraneoplastic Pemphigus. ( 29389687 )
2018
8
Efficacy of high-dose steroids for bronchiolitis obliterans syndrome post pediatric hematopoietic stem cell transplantation. ( 29417689 )
2018
9
Bronchiolitis obliterans syndrome is associated with increased p-glycoprotein expression and loss of glucocorticoid receptor from steroid-resistant proinflammatory CD8<sup>+</sup>T cells. ( 29352737 )
2018
10
The emerging spectrum of exposure-related bronchiolitis. ( 29394172 )
2018
11
Mycobacterium abscessus and massiliense lung infection during macrolide treatment for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. ( 28988958 )
2018
12
Post-infectious bronchiolitis obliterans in children: is general quality of life the right measure? ( 29438684 )
2018
13
The management of children with bronchiolitis in the Australasian hospital setting: development of a clinical practice guideline. ( 29433429 )
2018
14
No Cause for Alarm: Decreasing Inappropriate Pulse Oximetry Use in Bronchiolitis. ( 29382688 )
2018
15
Bronchodilators in bronchiolitis: Yes or no? ( 29333805 )
2018
16
RSV-hRV co-infection is a risk factor for recurrent bronchial obstruction and early sensitization 3 years after bronchiolitis. ( 29380391 )
2018
17
A case series on common cold to severe bronchiolitis and pneumonia in children following human metapneumovirus infection in Sri Lanka. ( 29444701 )
2018
18
Evaluating for Bronchiolitis Obliterans with Low Attenuation CT 3D Reconstructions. ( 29406777 )
2018
19
Helmet Versus Nasal-Prong CPAP in Infants With Acute Bronchiolitis. ( 29382794 )
2018
20
Network Meta-Analysis Comparing the Efficacy of Therapeutic Treatments for Bronchiolitis in Children. ( 29388676 )
2018
21
Comparing of two different epidemic seasons of bronchiolitis. ( 29338779 )
2018
22
Therapy options for chronic lung allograft dysfunction-bronchiolitis obliterans syndrome following first-line immunosuppressive strategies: A systematic review. ( 28662986 )
2017
23
Effects of Intraperitoneal Injection of Allogeneic Bone Marrow-derived Mesenchymal Stem Cells on Bronchiolitis Obliterans in Mice Model. ( 28732434 )
2017
24
Lung Clearance Index and Quantitative Computed Tomography of Post-Infectious Bronchiolitis Obliterans in Infants. ( 29123150 )
2017
25
Mycoplasma pneumoniae-Associated Bronchiolitis Obliterans Following Acute Bronchiolitis. ( 28814783 )
2017
26
Bronchiolitis Obliterans (Obliterative Bronchiolitis, Constrictive Bronchiolitis) ( 28722895 )
2017
27
Development of a Multivariate Prediction Model for Early-Onset Bronchiolitis Obliterans Syndrome and Restrictive Allograft Syndrome in Lung Transplantation. ( 28770204 )
2017
28
Respiratory reactance in children aged three to fiveA years with postinfectious bronchiolitis obliterans is higher than in those with asthma. ( 27743492 )
2017
29
Inert Gas Washout in Bronchiolitis Obliterans Following Hematopoietic Cell Transplantation. ( 29275133 )
2017
30
Neurologic and Functional Morbidity in Critically Ill Children With Bronchiolitis. ( 28930814 )
2017
31
MicroRNA-218 acts by repressing TNFR1-mediated activation of NF-I_B, which is involved in MUC5AC hyper-production and inflammation in smoking-induced bronchiolitis of COPD. ( 28864214 )
2017
32
Health-related quality of life in patients with bronchiolitis obliterans. ( 29172039 )
2017
33
Double lung, unlike single lung transplantation might provide a protective effect on mortality and bronchiolitis obliterans syndrome. ( 29178919 )
2017
34
Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children. ( 28567534 )
2017
35
Respiratory Syncytial Virus Bronchiolitis in Children. ( 28084708 )
2017
36
Impact of Forced Expiratory Volume in 1 Second (FEV1) and 6-Minute Walking Distance at 3, 6, and 12 Months and Annually on Survival and Occurrence of Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation. ( 28871078 )
2017
37
Development of bronchiolitis obliterans organizing pneumonia during standard treatment of hepatitis C with Peg-IFNI+2b. ( 28823117 )
2017
38
Early extracellular matrix changes are associated with later development of bronchiolitis obliterans syndrome after lung transplantation. ( 28469930 )
2017
39
Diacetyl and occupational bronchiolitis obliterans: Comments on Rose, CS: Early detection, clinical diagnosis and management of lung disease from exposure to diacetyl, toxicology (2017), https://doi.org/10.1016/j.tox.2017.03.019. ( 29054810 )
2017
40
Viral bronchiolitis in young infants: new perspectives for management and treatment. ( 28859915 )
2017
41
Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome. ( 29375549 )
2017
42
Eosinophilic Bronchiolitis. ( 28914741 )
2017
43
Chest computed tomography in bronchiolitis obliterans after bone marrow transplantation. ( 28670041 )
2017
44
IL-17 contributes to the pathogenesis of obliterative bronchiolitis via regulation of M1 macrophages polarization in murine heterotopic trachea transplantation models. ( 28863322 )
2017
45
Temporal Changes in Prescription of Neuropharmacologic Drugs and Utilization of Resources Related to Neurologic Morbidity in Mechanically Ventilated Children With Bronchiolitis. ( 28930813 )
2017
46
Clinical definition of respiratory viral infections in young children and potential bronchiolitis misclassification. ( 28947640 )
2017
47
Reduced PRF1 enhancer methylation in children with a history of severe RSV bronchiolitis in infancy: an association study. ( 28253869 )
2017
48
Continuous Positive Airway Pressure in Bronchiolitis: A Randomized Controlled Trial. ( 28952459 )
2017
49
Respiratory bronchiolitis-associated interstitial lung disease - an unexpected form of idiopathic interstitial pneumonia in a young male. ( 28523329 )
2017
50
Constrictive Bronchiolitis Attributable to Inhalation of Toxic Agents: Considerations for a Case Definition. ( 28953074 )
2017

Variations for Bronchiolitis

Expression for Bronchiolitis

Search GEO for disease gene expression data for Bronchiolitis.

Pathways for Bronchiolitis

Pathways related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.1 CCL11 CCL3 CCL5 CXCL8 IFNG IGHE
2
Show member pathways
13.94 CCL11 CCL3 CCL5 CXCL8 IL10 IL13
3
Show member pathways
13.82 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
4
Show member pathways
13.7 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
5
Show member pathways
13.52 CCL11 CCL3 CCL5 CXCL8 IFNG IGHE
6
Show member pathways
13.47 CCL11 CCL3 CCL5 CXCL8 IL10 IL13
7
Show member pathways
13.39 CCL11 CCL3 CCL5 CXCL8 IL10 IL13
8
Show member pathways
13.33 IFNG IL4 IL4R TLR1 TLR10 TLR4
9
Show member pathways
13.16 CCL5 CXCL8 IL6 MUC5B TLR1 TLR10
10
Show member pathways
13.04 CCL11 CXCL8 IFNG IL10 IL13 IL4
11
Show member pathways
12.99 CCL5 CXCL8 IFNG IL13 IL4 IL6
12 12.98 CXCL8 IFNG IL13 IL4 IL4R IL5
13
Show member pathways
12.83 IL6 TLR1 TLR10 TLR4 TLR9 TNF
14
Show member pathways
12.8 IFNG IL10 IL13 IL4 IL4R IL5
15
Show member pathways
12.78 CCL5 CXCL8 IFNG IL6 TNF
16
Show member pathways
12.76 IFNG IGHE IL10 IL4 IL4R TNF
17 12.75 CCL5 IFNG IL10 IL4 TLR1 TLR9
18
Show member pathways
12.7 CCL3 CCL5 CXCL8 IFNG IL10 IL6
19
Show member pathways
12.68 TLR1 TLR10 TLR4 TLR9 TNF
20
Show member pathways
12.67 IGHE IL13 IL4 IL5 TNF
21
Show member pathways
12.6 IFNG IL10 IL4 IL5 IL6 TNF
22
Show member pathways
12.57 IFNG IL10 IL13 IL4 IL4R IL5
23
Show member pathways
12.52 CCL11 CXCL8 IFNG IL13 IL4 IL5
24
Show member pathways
12.48 CXCL8 IL6 TLR1 TLR10 TLR4 TLR9
25
Show member pathways
12.46 CCL5 IFNG IL4 IL6 TNF
26
Show member pathways
12.44 CCL11 IGHE IL4 IL4R
27 12.44 IFNG IL10 IL6 TLR1 TLR4 TLR9
28
Show member pathways
12.41 CXCL8 IFNG IL6 TLR4 TNF
29
Show member pathways
12.39 IFNG IL10 IL4 TLR4 TNF
30 12.39 IFNG IL6 TLR1 TLR10 TLR4 TLR9
31
Show member pathways
12.36 CXCL8 IFNG IL10 IL13 IL4 IL5
32 12.33 CXCL8 IL10 IL13 IL6 TNF
33
Show member pathways
12.3 CCL11 CXCL8 IFNG IL4 IL6 TLR1
34
Show member pathways
12.25 IL13 IL5 TLR1 TLR10 TLR4 TLR9
35 12.23 CXCL8 IFNG IL4 IL6 TLR4 TNF
36 12.21 IFNG IL10 IL4 IL5 IL6 TNF
37 12.16 TLR1 TLR10 TLR4 TLR9
38 12.12 CXCL8 IFNG IL10 IL6 TLR4 TNF
39
Show member pathways
12.11 IFNG IL10 IL6 TLR1 TLR10 TLR4
40
Show member pathways
12.1 CCL11 CCL3 CCL5 CXCL8
41 12.09 IL4 IL4R IL5 IL6 TNF
42 12.09 CCL3 CCL5 CXCL8 IFNG IL6 TLR4
43 12.06 CCL3 CXCL8 IFNG IL6
44 12.03 CCL3 CXCL8 IFNG IL6 TLR4
45 12.03 CXCL8 IFNG IL13 IL4 IL5 IL6
46 12.02 CCL3 IFNG IL10 IL13 IL4 IL5
47
Show member pathways
11.97 CXCL8 IFNG IL4 IL5 TNF
48 11.97 CXCL8 IL10 IL6 TLR4 TNF
49
Show member pathways
11.97 IFNG IL4 IL4R IL6 TLR1 TLR10
50 11.97 CCL11 CXCL8 IGHE IL10 IL13 IL4

GO Terms for Bronchiolitis

Cellular components related to Bronchiolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 CCL11 CCL3 CCL5 CXCL8 IFNG IGHE
2 extracellular space GO:0005615 9.5 CCL11 CCL3 CCL5 CXCL8 IFNG IL10

Biological processes related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Name GO ID Score Top Affiliating Genes
1 cellular response to tumor necrosis factor GO:0071356 9.99 CCL11 CCL3 CCL5 CXCL8
2 response to virus GO:0009615 9.97 CCL11 CCL5 IFNG TNF
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.97 IL10 IL5 IL6 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.96 CXCL8 IL10 IL6 TLR4 TNF
5 defense response to Gram-negative bacterium GO:0050829 9.95 IL6 RNASE3 TLR4 TLR9
6 cellular response to interleukin-1 GO:0071347 9.93 CCL11 CCL3 CCL5 CXCL8
7 movement of cell or subcellular component GO:0006928 9.92 CXCL8 IFNG IL13
8 chemokine-mediated signaling pathway GO:0070098 9.92 CCL11 CCL3 CCL5 CXCL8
9 positive regulation of inflammatory response GO:0050729 9.92 CCL3 TLR10 TLR4 TLR9
10 cellular response to organic cyclic compound GO:0071407 9.91 CCL3 CCL5 TNF
11 positive regulation of JNK cascade GO:0046330 9.91 TLR4 TLR9 TNF
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 CCL5 IFNG IL13 IL6
13 neutrophil chemotaxis GO:0030593 9.91 CCL11 CCL3 CCL5 CXCL8
14 defense response to bacterium GO:0042742 9.91 IGHE IL10 RNASE3 TLR1 TLR4 TLR9
15 regulation of insulin secretion GO:0050796 9.9 CCL5 IFNG TNF
16 positive regulation of B cell activation GO:0050871 9.9 IGHE IL6 TLR9
17 response to glucocorticoid GO:0051384 9.9 IL10 IL6 TNF
18 positive regulation of T cell proliferation GO:0042102 9.9 CCL5 IL4 IL6
19 regulation of receptor activity GO:0010469 9.9 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
20 humoral immune response GO:0006959 9.89 IFNG IL6 TNF
21 positive regulation of tumor necrosis factor production GO:0032760 9.88 CCL3 TLR4 TLR9
22 protein kinase B signaling GO:0043491 9.88 CCL3 CCL5 TNF
23 positive regulation of smooth muscle cell proliferation GO:0048661 9.88 CCL5 IL13 IL6 TNF
24 positive regulation of interleukin-6 production GO:0032755 9.88 IL6 TLR4 TLR9 TNF
25 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 IFNG TLR4 TNF
26 immune response GO:0006955 9.86 CCL11 CCL3 CCL5 CXCL8 IFNG IGHE
27 negative regulation of endothelial cell apoptotic process GO:2000352 9.85 IL10 IL13 IL4
28 toll-like receptor signaling pathway GO:0002224 9.85 TLR1 TLR10 TLR4 TLR9
29 positive regulation of interleukin-8 production GO:0032757 9.84 TLR4 TLR9 TNF
30 monocyte chemotaxis GO:0002548 9.84 CCL11 CCL3 CCL5 IL6
31 positive regulation of interleukin-12 production GO:0032735 9.83 IFNG TLR4 TLR9
32 positive regulation of NF-kappaB import into nucleus GO:0042346 9.83 TLR4 TLR9 TNF
33 negative regulation of osteoclast differentiation GO:0045671 9.83 CCL3 IL4 TLR4
34 positive regulation of JAK-STAT cascade GO:0046427 9.81 CCL5 IL5 IL6
35 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.8 TLR1 TLR10 TLR4 TLR9
36 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 CCL3 CCL5 TLR4 TNF
37 response to molecule of bacterial origin GO:0002237 9.77 CXCL8 IL10 TLR9
38 negative regulation of interleukin-6 production GO:0032715 9.76 IL10 TLR4 TLR9 TNF
39 positive regulation of podosome assembly GO:0071803 9.75 IL5 TNF
40 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.75 IL10 TNF
41 I-kappaB phosphorylation GO:0007252 9.75 TLR4 TLR9
42 positive regulation of immunoglobulin secretion GO:0051024 9.75 IL5 IL6
43 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.75 CCL5 CXCL8
44 negative regulation by host of viral transcription GO:0043922 9.74 CCL3 CCL5
45 neutrophil activation GO:0042119 9.74 CCL5 CXCL8
46 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.74 TLR1 TLR4
47 negative regulation of interleukin-17 production GO:0032700 9.74 IFNG TLR4
48 macrophage activation GO:0042116 9.74 TLR1 TLR4
49 eosinophil chemotaxis GO:0048245 9.74 CCL11 CCL3 CCL5
50 negative regulation of lipid storage GO:0010888 9.73 IL6 TNF

Molecular functions related to Bronchiolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 IL10 IL4 IL5 IL6
2 CCR5 chemokine receptor binding GO:0031730 9.37 CCL3 CCL5
3 cytokine activity GO:0005125 9.36 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
4 phospholipase activator activity GO:0016004 9.32 CCL3 CCL5
5 chemokine activity GO:0008009 9.26 CCL11 CCL3 CCL5 CXCL8
6 CCR1 chemokine receptor binding GO:0031726 9.16 CCL3 CCL5

Sources for Bronchiolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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