MCID: BRN002
MIFTS: 60

Bronchiolitis malady

Respiratory diseases category

Summaries for Bronchiolitis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. it is caused by viruses and bacteria. the disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.

MalaCards: Bronchiolitis is related to bronchiolitis obliterans organizing pneumonia and bronchiolitis obliterans, and has symptoms including fever, wheezing and shortness of breath. An important gene associated with Bronchiolitis is IL8 (interleukin 8), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and Cytokine production by Th17 cells in CF. The compounds formoterol and fluticasone propionate have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and bone, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Wikipedia:66 Bronchiolitis is inflammation of the bronchioles, the smallest air passages of the lungs. It usually... more...

Aliases & Classifications for Bronchiolitis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

bronchiolitis 9 11 46 63


External Ids:

Disease Ontology9 DOID:2942
NCIt41 C39658
SNOMED-CT59 4120002
MeSH36 D001988

Related Diseases for Bronchiolitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Bronchiolitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1bronchiolitis obliterans organizing pneumonia31.8TOMM5
2bronchiolitis obliterans31.8HMOX1, SCGB1A1, MMP8, CXCL10, CXCR3, IL17A
3pneumonia31.3HMOX1, TLR4, SCGB1A1, MMP8, CXCL10, IL17A
4asthma31.1RNASE3, IL13
5interstitial lung disease30.9PDGFB, IL8
6cryptogenic organizing pneumonia30.8TOMM5
7arthritis30.7IL17A, IL8
8eosinophilic pneumonia30.4RNASE3, IL13
9respiratory failure30.4RNASE3, SCGB1A1, IL13, CXCL10
10bronchitis30.4RNASE3, IL8
11systemic lupus erythematosus30.4CXCR3, CRP, CXCL10, IL17A, TLR4
12cystic fibrosis30.3ALB, SCGB1A1, TLR4, RNASE3, IL17A, IL8
13rheumatoid arthritis30.3RNASE3, MMP8, CXCL10, CXCR3, IL17A, IL8
14sarcoidosis30.2PDGFB, IL13, CXCR3, CXCL10, SCGB1A1
15lung cancer30.2MMP8, PDGFB, SCGB1A1, TLR4, CXCR3
16hepatitis30.2CXCL10, IFNA2, PDGFB
17leukemia30.1IFNA2, SCGB1A1, PDGFB, CXCR3, IL17A, TLR4
18bronchiectasis30.1IL8, MMP8, RNASE3
19bronchopulmonary dysplasia30.1IL8, SCGB1A1, RNASE3
20ulcerative colitis30.1IL17A, CXCL10, CRP, IL13, IL8, CXCR3
21pulmonary emphysema30.1MMP8, HMOX1
22eosinophilia30.1IL13, IL8, IFNA2, RNASE3
23breast cancer30.1CXCR3, CXCL10, MMP8, HMOX1, SCGB1A1, ALB
24hepatitis c30.0CXCL10, IFNA2, TLR4, CXCR3
25atopy30.0IL13, SCGB1A1, RNASE3, TLR4, CXCR3
26pulmonary fibrosis30.0IL8, HMOX1, PDGFB, IL13, CXCR3
27malaria29.9ALB
28extrinsic allergic alveolitis29.9IL8, CXCR3
29tuberculosis29.9PDGFB, ALB, IL17A, CXCR3, CXCL10, TLR4
30pulmonary eosinophilia29.9RNASE3, IL13, IL8
31pulmonary sarcoidosis29.8CXCR3, PDGFB
32ankylosing spondylitis29.8TLR4, CRP, IL17A
33hepatitis b29.7CXCL10, ALB, IFNA2, TLR4
34idiopathic pulmonary fibrosis29.7PDGFB, IL13, IL8, CXCR3, CXCL10, SCGB1A1
35congenital heart disease29.6CRP, TLR4, ALB, HMOX1
36hematopoietic stem cell transplantation10.6
37respiratory bronchiolitis-associated interstitial lung disease10.5
38pemphigus10.4
39paraneoplastic pemphigus10.4
40diffuse panbronchiolitis10.4
41nasopharyngitis10.4
42graft versus host disease10.3
43croup10.3
44desquamative interstitial pneumonia10.3
45lupus erythematosus10.3
46pneumothorax10.3
47chronic graft versus host disease10.3
48castleman's disease10.2
49bronchiolitis obliterans with obstructive pulmonary disease10.2
50usual interstitial pneumonia10.2

Graphical network of the top 20 diseases related to Bronchiolitis:



Diseases related to bronchiolitis

Symptoms for Bronchiolitis

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9Disease Ontology
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Symptoms:

9
  • fever
  • wheezing
  • shortness of breath
  • nasal flaring in infants
  • bluish skin due to lack of oxygen
  • cough

Drugs & Therapeutics for Bronchiolitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Bronchiolitis

Drug clinical trials:

Search ClinicalTrials for Bronchiolitis

Search NIH Clinical Center for Bronchiolitis

Search CenterWatch for Bronchiolitis

Genetic Tests for Bronchiolitis

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Anatomical Context for Bronchiolitis

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34MalaCards
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MalaCards organs/tissues related to Bronchiolitis:

34
Lung, Skin, Bone, Bone marrow, Breast, T cells, Colon, Liver, Heart, B cells, Testes, Thyroid, Trachea, Whole blood, Thymus, Kidney, Smooth muscle

Animal Models for Bronchiolitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Bronchiolitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4TLR4, SCGB1A1, MMP8, CXCR3, ALB
2MP:00053678.1HMOX1, PDGFB, ALB, IL17A, CXCR3, SCGB1A1
3MP:00053887.9IL17A, HMOX1, PDGFB, IL13, CXCR3, TOMM5
4MP:00053847.8HMOX1, MAPKAP1, ALB, IL13, CXCR3, CXCL10
5MP:00053857.6CRP, CXCL10, TOMM5, TLR4, PDGFB, HMOX1
6MP:00053977.6CXCL10, CXCR3, TOMM5, IL17A, IL8, IL13
7MP:00053766.8IL13, CXCL10, CXCR3, IL17A, ALB, CRP
8MP:00053876.7TLR4, HMOX1, CRP, PDGFB, IL13, IL17A
9MP:00107686.6SCGB1A1, CXCL10, PDGFB, ALB, MAPKAP1, CXCR3

Publications for Bronchiolitis

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53PubMed
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Articles related to Bronchiolitis:

(show top 50)    (show all 1191)
idTitleAuthorsYear
1
Effects of prophylactic use of sirolimus on bronchiolitis obliterans syndrome development in lung transplant recipients. (24119986)
2014
2
Club cell secretory protein improves survival in a murine obliterative bronchiolitis model. (23997179)
2013
3
Aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans. (23062110)
2013
4
Chest health surveillance utility in the early detection of bronchiolitis obliterans syndrome in children after allo-SCT. (23165500)
2013
5
Variation and trends in ED use of radiographs for asthma, bronchiolitis, and croup in children. (23878045)
2013
6
A relevant experimental model for human bronchiolitis obliterans syndrome. (24050896)
2013
7
Risk factors for bronchiolitis obliterans syndrome in allogeneic hematopoietic stem cell transplantation. (23823823)
2013
8
HIV-associated follicular bronchiolitis. (23947519)
2013
9
Occupational causes of constrictive bronchiolitis. (23407121)
2013
10
Better newborn vitamin D status lowers RSV-associated bronchiolitis in infants. (22946854)
2012
11
Impact of a bronchiolitis clinical care pathway on treatment and hospital stay. (22193364)
2012
12
Nasopharyngeal airway pressures in bronchiolitis patients treated with high-flow nasal cannula oxygen therapy. (23114244)
2012
13
Rapid acute onset of bronchiolitis obliterans syndrome in a lung transplant recipient after respiratory syncytial virus infection. (22650803)
2012
14
Bronchiolitis obliterans syndrome is associated with increased peripheral blood natural killer and natural killer T-like granzymes, perforin, and T-helper-type 1 pro-inflammatory cytokines. (22759800)
2012
15
Clinical predictors of nasal continuous positive airway pressure requirement in acute bronchiolitis. (21901857)
2012
16
Current therapy for bronchiolitis. (22734014)
2012
17
Serum levels of lipoxin A(4) do not predict the development of subsequent asthma among young children with acute bronchiolitis. (21671842)
2011
18
Ingraft chimerism in lung transplantation--a study in a porcine model of obliterative bronchiolitis. (21521503)
2011
19
Household tobacco smoke and admission weight predict severe bronchiolitis in infants independent of deprivation: prospective cohort study. (21811609)
2011
20
Breathing easy: implementing a bronchiolitis protocol. (21739745)
2011
21
Helium-oxygen therapy for infants with bronchiolitis: a randomized controlled trial. (22147778)
2011
22
HBs seroconversion in a patient with acute hepatitis B treated with entecavir during immunosuppression against severe bronchiolitis obliterans in the course of chronic graft versus host disease. (20403727)
2010
23
Local IL-17 production and a decrease in peripheral blood regulatory T cells in an animal model of bronchiolitis obliterans. (20393404)
2010
24
The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation. (20456980)
2010
25
Systemic and exhaled cytokine and chemokine profiles are associated with the development of bronchiolitis obliterans syndrome. (20627628)
2010
26
Air-leak and transient coronary artery dilation in post-infectious bronchiolitis obliterans. (20958871)
2010
27
The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation. (19299743)
2009
28
Effect of maintenance azithromycin on established bronchiolitis obliterans syndrome in lung transplant patients. (18551201)
2008
29
Neutrophil but not eosinophil inflammation is related to the severity of a first acute epidemic bronchiolitis in young infants. (18093085)
2008
30
Soluble CD30 levels as a diagnostic marker for bronchiolitis obliterans syndrome following human lung transplantation. (18047935)
2008
31
Bronchiolitis obliterans syndrome: alloimmune-dependent and -independent injury with aberrant tissue remodeling. (18707652)
2008
32
Respiratory bronchiolitis-associated interstitial lung disease in a nonsmoker: radiologic and pathologic findings. (17449735)
2007
33
Lung transplantation in the Fischer 344-->Wistar Kyoto rat strain combination is not suitable to study bronchiolitis obliterans. (17403482)
2007
34
Cytokines in the nasal washes of children with respiratory syncytial virus bronchiolitis. (16569362)
2006
35
Fatal coronary artery anomaly presenting as bronchiolitis. (16602012)
2006
36
Improvement of pulmonary function with imatinib mesylate in bronchiolitis obliterans following allogeneic hematopoietic cell transplantation. (16785069)
2006
37
Genetic variation at the IL10 gene locus is associated with severity of respiratory syncytial virus bronchiolitis. (15838798)
2005
38
The incidence and clinical characteristics of bronchiolitis obliterans organizing pneumonia syndrome after radiation therapy for breast cancer. (15554078)
2004
39
Solitary nodular form of bronchiolitis obliterans organizing pneumonia. (15589500)
2004
40
A case of bronchiolitis obliterans organizing pneumonia syndrome with preceding radiation pneumonitis after breast-conserving therapy. (15640508)
2004
41
Bronchiolitis obliterans organizing pneumonia associated with sulfasalazine in a patient with rheumatoid arthritis. (15168156)
2004
42
Enhanced IL-4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy. (12212970)
2002
43
Increased exhaled nitric oxide in bronchiolitis obliterans organizing pneumonia after allogeneic bone marrow transplantation. (12451281)
2002
44
Bronchiolitis obliterans organizing pneumonia associated with Evans syndrome. (11786723)
2001
45
Bilateral symmetrical upper-lobe opacities: an unusual presentation of bronchiolitis obliterans organizing pneumonia. (10988217)
2000
46
Bronchiolitis obliterans organizing pneumonia. Trying to answer an intriguing question. (11185490)
2000
47
Platelet-derived growth factor in bronchiolitis obliterans-organizing pneumonia. (9032212)
1997
48
Bronchiolitis obliterans organizing pneumonia associated with systemic lupus erythematosus with antiphospholipid antibody. (8739795)
1996
49
Bronchiolitis obliterans in a patient with localized scleroderma treated with D-penicillamine. (8804954)
1996
50
Chronic eosinophilic pneumonia and idiopathic bronchiolitis obliterans organizing pneumonia: comparison of eosinophil number and degranulation by immunofluorescence staining for eosinophil-derived major basic protein. (7531262)
1995

Variations for Bronchiolitis

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Expression for genes affiliated with Bronchiolitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bronchiolitis

Search GEO for disease gene expression data for Bronchiolitis.

Pathways for genes affiliated with Bronchiolitis

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Sources:
51PathCards, 55R&D Systems, 56Reactome, 61Thomson Reuters, 31KEGG, 54QIAGEN, 39NCBI BioSystems Database, 13EMD Millipore
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Pathways related to Bronchiolitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7IL8, CXCR3, CXCL10
2
Show member pathways
9.7TLR4, IL17A, IL8
39.7IL8, IL17A, TLR4
49.6IL13, IL8, IFNA2
5
Show member pathways
9.6CXCL10, IFNA2, IL8
69.6IL8, CXCL10, TLR4
7
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.6IL8, CXCL10, TLR4
8
Show member pathways
9.6IL13, IL17A, TLR4
99.5CXCL10, CXCR3, MAPKAP1
10
Show member pathways
9.5IL8, CXCR3, CXCL10, MMP8
119.4ALB, MMP8, SCGB1A1
12
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.2TLR4, CXCL10, IFNA2, IL8
13
Show member pathways
9.1CXCL10, CXCR3, IL8, IL13, PDGFB
14
Show member pathways
9.1CXCL10, CXCR3, IL8, IL13, PDGFB
15
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.1HMOX1, IL8, IFNA2, TLR4
16
Show member pathways
9.0TLR4, CXCL10, IFNA2, IL8, IL13
17
Show member pathways
8.7TLR4, CXCL10, CXCR3, IL8, IL13, PDGFB
18
Show member pathways
8.1PDGFB, TLR4, CXCL10, CXCR3, IFNA2, IL17A

Compounds for genes affiliated with Bronchiolitis

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Bronchiolitis according to GeneCards/GeneDecks:

(show top 50)    (show all 149)
idCompoundScoreTop Affiliating Genes
1formoterol46 30 1212.0IL13, IL8, RNASE3
2fluticasone propionate46 52 62 1212.8RNASE3, IL13, CXCL10, IL8
3salmeterol46 52 30 1212.8IL8, IL13, RNASE3
4tarc469.7CXCL10, IL13, IL8, CXCR3
5ccl446 3010.7IL13, CXCL10, CXCR3, IL17A
6groalpha469.6IL8, CXCL10, IL17A, CXCR3, IL13
7fmlp469.5TLR4, IL13, IL8, CXCR3, RNASE3
8il 10469.4TLR4, IL8, CXCR3, CXCL10, IL13
9ccl346 3010.4CXCR3, TLR4, IL13, IL8, CXCL10
10allergens469.4TLR4, CXCL10, CXCR3, RNASE3, IL13
11methacholine46 52 1211.4RNASE3, IL17A, IL8, IL13, CRP
12p002469.4SCGB1A1, CRP, IL17A, MMP8, RNASE3
13neopterin469.3CRP, CXCL10, IFNA2, IL8
14etanercept46 52 1211.3IL8, IL17A, IFNA2, CRP, CXCR3
15gamma globulin469.3IFNA2, ALB, CRP
16hyaluronic acid46 2510.2SCGB1A1, RNASE3, ALB, IL8, IL13
17ifn-alpha469.1CXCL10, CXCR3, IFNA2, IL17A, TLR4, IL13
18thymidine46 2510.0PDGFB, IL13, CXCR3, IFNA2, IL17A, CXCL10
19aspirin46 52 30 2511.9CRP, HMOX1, IL13, RNASE3, TLR4
20superoxide46 259.9IL8, IFNA2, MMP8, HMOX1, TLR4, CXCR3
21infliximab46 52 1210.9TLR4, CXCL10, CXCR3, IFNA2, IL17A, CRP
22chloramphenicol46 3 52 1211.8CRP, PDGFB, IL13, SCGB1A1, HMOX1
23prednisolone46 30 1210.8IL13, ALB, IFNA2, CRP, RNASE3
24n acetylcysteine468.8HMOX1, CRP, IL8, RNASE3, TLR4
25sb 20358046 629.8CRP, IL13, IL8, IL17A, TLR4, HMOX1
26vitamin a46 25 1210.7ALB, IL13, SCGB1A1, IFNA2, CRP
27alpha tocopherol468.6IFNA2, IL13, HMOX1, CRP, ALB
28rantes468.6CXCL10, TLR4, RNASE3, IL13, IL8, IL17A
29cyclosporin a46 30 6210.6TLR4, RNASE3, HMOX1, PDGFB, IL13, IL8
30oxygen46 259.5MMP8, SCGB1A1, CXCR3, IFNA2, IL8, PDGFB
31indomethacin46 30 62 1211.5IFNA2, IL17A, HMOX1, IL13, ALB
32ly294002468.5HMOX1, CRP, IL13, CXCR3, TLR4, IL17A
33tacrolimus46 52 1210.5CXCR3, IL17A, TLR4, IL13, ALB, PDGFB
34polyethylene glycol468.4IFNA2, HMOX1, CRP, ALB
35creatinine468.4ALB, CXCL10, RNASE3, SCGB1A1, CXCR3, CRP
36cycloheximide468.4HMOX1, CXCL10, IL8, IL13, PDGFB, TLR4
37retinoic acid46 259.3HMOX1, IL13, IFNA2, CXCL10, MMP8, TLR4
38pge2468.3HMOX1, TLR4, RNASE3, MMP8, CXCL10, CXCR3
39aspartate468.3IL13, SCGB1A1, IFNA2, TLR4, ALB, CRP
40endotoxin468.3CRP, IL13, IL8, IL17A, CXCR3, CXCL10
41dexamethasone46 52 30 1211.2IL13, IL17A, CXCL10, TLR4, PDGFB, HMOX1
42iron46 259.2HMOX1, TLR4, CRP, ALB, IFNA2, SCGB1A1
43estrogen468.2SCGB1A1, RNASE3, CXCL10, IFNA2, IL17A, IL13
44lactate468.0TLR4, RNASE3, IL13, MMP8, IL8, ALB
45histamine46 30 259.8HMOX1, ALB, CXCL10, IL8, IFNA2, CXCR3
46nitric oxide46 25 129.8TLR4, SCGB1A1, RNASE3, MMP8, CXCR3, IL17A
47cysteine467.7HMOX1, TLR4, MMP8, IFNA2, IL8, IL13
48alanine467.5HMOX1, CRP, ALB, IL13, IFNA2, CXCL10
49lipid467.5PDGFB, CRP, SCGB1A1, RNASE3, MMP8, CXCL10
50vegf467.2HMOX1, TLR4, RNASE3, MMP8, CRP, PDGFB

GO Terms for genes affiliated with Bronchiolitis

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17Gene Ontology
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Cellular components related to Bronchiolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0IL13, IL17A, CXCR3, CXCL10, TLR4
2extracellular regionGO:0055767.1RNASE3, MMP8, CXCL10, IFNA2, IL8, IL13
3extracellular spaceGO:0056156.6HMOX1, SCGB1A1, MMP8, CXCL10, IFNA2, IL17A

Biological processes related to Bronchiolitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:03081610.1CXCR3, CXCL10
2T cell chemotaxisGO:01081810.1CXCR3, CXCL10
3positive regulation of chemotaxisGO:05092110.0PDGFB, CXCR3
4positive regulation of cAMP-mediated signalingGO:04395010.0CXCR3, CXCL10
5positive regulation of release of sequestered calcium ion into cytosolGO:0512819.9IL13, CXCR3, CXCL10
6cellular component movementGO:0069289.9CXCR3, IL8, IL13
7negative regulation of interferon-gamma productionGO:0326899.8SCGB1A1, TLR4
8chemotaxisGO:0069359.8CXCL10, CXCR3, IL8
9positive regulation of smooth muscle cell proliferationGO:0486619.7IL13, PDGFB, HMOX1
10response to lipopolysaccharideGO:0324969.5TLR4, SCGB1A1, CXCL10, IL13
11cell-cell signalingGO:0072679.5CXCL10, IFNA2, IL17A, IL13
12cell surface receptor signaling pathwayGO:0071669.5CXCL10, CXCR3, IFNA2
13response to nicotineGO:0350949.4HMOX1, IL13
14immune responseGO:0069559.3IL13, IL8, IL17A, CXCL10, TLR4
15inflammatory responseGO:0069548.6CRP, CXCL10, CXCR3, IFNA2, IL17A, IL8
16signal transductionGO:0071658.6RASSF6, IL13, IL8, CXCL10, SCGB1A1

Molecular functions related to Bronchiolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.6IL13, IL17A, IFNA2
2protein bindingGO:0055155.7RASSF6, TLR4, SCGB1A1, CXCL10, IFNA2, IL8

Products for genes affiliated with Bronchiolitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bronchiolitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet