MCID: BRN002
MIFTS: 61

Bronchiolitis malady

Summaries for Bronchiolitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. it is caused by viruses and bacteria. the disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.

MalaCards: Bronchiolitis is related to bronchiolitis obliterans and pneumonia, and has symptoms including bluish skin due to lack of oxygen, nasal flaring in infants and fever. An important gene associated with Bronchiolitis is IL8 (interleukin 8), and among its related pathways are Akt Signaling and PEDF Induced Signaling. The compounds vegf and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and bone, and related mouse phenotypes are immune system and mortality/aging.

Wikipedia:63 Bronchiolitis is inflammation of the bronchioles, the smallest air passages of the lungs. It usually... more...

Aliases & Classifications for Bronchiolitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

bronchiolitis 8 10 44 60


External Ids:

Disease Ontology8 DOID:2942
MeSH34 D001988
SNOMED-CT56 4120002
NCIt39 C39658

Related Diseases for Bronchiolitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bronchiolitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 252)
idRelated DiseaseScoreTop Affiliating Genes
1bronchiolitis obliterans31.9SCGB1A1, IL8, BMP6, MMP8, CXCR3, CXCL10
2pneumonia31.6IL8, TLR4, SCGB1A1, PIK3C2A, MMP8, IL13
3bronchiolitis obliterans organizing pneumonia31.5TOMM5
4asthma30.9IL13, RNASE3
5interstitial lung disease30.7IL8, PDGFB, BMP6
6cryptogenic organizing pneumonia30.6TOMM5
7rheumatoid arthritis30.5RNASE3, TLR4, BMP6, CXCR3, CXCL10, IL17A
8arthritis30.5IL13, CXCR3, IL8, CXCL10, MMP8, IL17A
9cystic fibrosis30.4HMOX1, SCGB1A1, TLR4, IL8, IL17A, RNASE3
10systemic lupus erythematosus30.4CXCL10, TLR4, IL17A, CXCR3
11leukemia30.3SCGB1A1, RNASE3, CXCR3, HMOX1, PDGFB, TLR4
12lung cancer30.3SCGB1A1, PDGFB, CHKA, MMP8, TLR4, CXCR3
13breast cancer30.2BMP6, SCGB1A1, HMOX1, CHKA, CXCR3, CXCL10
14ulcerative colitis30.2IL8, CXCR3, IL13, TLR4, RNASE3, IL17A
15respiratory failure30.2CXCL10, IL13, RNASE3, SCGB1A1
16eosinophilic pneumonia30.2IL13, RNASE3
17pulmonary fibrosis30.2PDGFB, IL8, CXCR3, BMP6, HMOX1, IL13
18sarcoidosis30.2SCGB1A1, CXCL10, CXCR3, IL13, PDGFB
19bronchitis30.2RNASE3
20tuberculosis30.1CXCL10, IL17A, PDGFB, CXCR3, TLR4
21hepatitis30.1IFNA2, CXCL10, PDGFB
22influenza30.1CXCL10, CXCR3
23eosinophilia29.9IFNA2, IL8, RNASE3, IL13, PIK3C2A
24ischemia29.9HMOX1, CHKA, PIK3C2A, PDGFB, IL17A
25hepatitis c29.9TLR4, CXCR3, IFNA2, CXCL10
26dermatomyositis29.9IL17A, PIK3C2A, CHKA
27bronchiectasis29.9MMP8, IL8, RNASE3
28pulmonary emphysema29.9HMOX1, MMP8
29idiopathic pulmonary fibrosis29.7IL8, CXCR3, CXCL10, BMP6, IL13, SCGB1A1
30pulmonary eosinophilia29.7IL8, RNASE3, IL13
31hepatitis b29.7IL17A, IFNA2, CXCL10
32myopathy29.7CHKA, PIK3C2A
33otitis media29.7RNASE3
34aspergillosis29.7TLR4
35cryoglobulinemia29.7IFNA2
36herpes simplex29.7CXCL10
37respiratory bronchiolitis-associated interstitial lung disease10.5
38pemphigus10.4
39nasopharyngitis10.3
40graft versus host disease10.3
41croup10.3
42desquamative interstitial pneumonia10.3
43lupus erythematosus10.3
44pneumothorax10.2
45diffuse panbronchiolitis10.2
46bronchiolitis obliterans with obstructive pulmonary disease10.2
47chronic eosinophilic pneumonia10.1
48bronchopneumonia10.1
49bronchial disease10.1
50stevens-johnson syndrome10.1

Graphical network of the top 20 diseases related to Bronchiolitis:



Diseases related to bronchiolitis

Clinical Features for Bronchiolitis

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8Disease Ontology
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Symptoms:

8
  • bluish skin due to lack of oxygen
  • nasal flaring in infants
  • fever
  • shortness of breath
  • wheezing
  • cough

Drugs & Therapeutics for Bronchiolitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bronchiolitis

Drug clinical trials:

Search ClinicalTrials for Bronchiolitis

Search NIH Clinical Center for Bronchiolitis

Search CenterWatch for Bronchiolitis

Genetic Tests for Bronchiolitis

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Anatomical Context for Bronchiolitis

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32MalaCards
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MalaCards organs/tissues related to Bronchiolitis:

32
Lung, Skin, Bone, Bone marrow, Breast, T cells, Colon, Liver, Heart, B cells, Testes, Thyroid, Trachea, Kidney, Smooth muscle, Thymus, Whole blood

Animal Models for Bronchiolitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bronchiolitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.9HMOX1, TLR4, PDGFB, SCGB1A1, PIK3C2A, TOMM5
2MP:001076811.8TLR4, PDGFB, SCGB1A1, PIK3C2A, TOMM5, CHKA
3MP:000537611.6PDGFB, SCGB1A1, PIK3C2A, CHKA, CXCR3, CXCL10
4MP:000539711.2TLR4, PDGFB, PIK3C2A, TOMM5, CXCL10, IL13
5MP:000536711.1TLR4, PDGFB, SCGB1A1, PIK3C2A, IL17A, HMOX1
6MP:000538810.9SCGB1A1, TOMM5, CXCR3

Publications for Bronchiolitis

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Sources:
50PubMed
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Articles related to Bronchiolitis:

(show top 50)    (show all 1202)
idTitleAuthorsYear
1
Temporal trends in emergency department visits for bronchiolitis in the United States, 2006 to 2010. (23934206)
2014
2
Propylthiouracil-induced bronchiolitis obliterans organizing pneumonia. (24292758)
2013
3
Orthotopic and heterotopic tracheal transplantation model in studying obliterative bronchiolitis. (23619376)
2013
4
Prognostic value of clinical, morphologic, and immunohistochemical factors in patients with bronchiolitis obliterans-organizing pneumonia. (23114922)
2013
5
Gram-negative infection and bronchiectasis in lung transplant recipients with bronchiolitis obliterans syndrome. (23225511)
2013
6
Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. (22869493)
2012
7
In the face of chronic aspiration, prolonged ischemic time exacerbates obliterative bronchiolitis in rat pulmonary allografts. (22882880)
2012
8
Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis. (21901859)
2012
9
Renal transplant with bronchiolitis obliterans organizing pneumonia (BOOP) attributable to tacrolimus and herpes simplex virus (HSV) pneumonia. (21996615)
2012
10
Determinants of asthma after severe respiratory syncytial virus bronchiolitis. (22444510)
2012
11
Impact on parents of bronchiolitis hospitalization of full-term, preterm and congenital heart disease infants. (23114197)
2012
12
Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants. (22713595)
2012
13
Pilot study of vapotherm oxygen delivery in moderately severe bronchiolitis. (22100741)
2012
14
Pulmonary mechanics following albuterol therapy in mechanically ventilated infants with bronchiolitis. (22741817)
2012
15
Timely detection of bronchiolitis epidemics in Guadeloupe. (23099868)
2012
16
Risk factors for admission in children with bronchiolitis from pediatric emergency department observation unit. (23114233)
2012
17
Bronchiolitis: too-familiar yet too-mysterious disease of childhood. (22473888)
2012
18
Fatal bronchiolitis obliterans complicating Stevens-Johnson syndrome following treatment with nimesulide: a case report. (21781423)
2011
19
Bronchiolitis obliterans organizing pneumonia, 25 years: a variety of causes, but what are the treatment options? (21702658)
2011
20
When should nebulized hypertonic saline solution be used in the treatment of bronchiolitis? (22379380)
2011
21
A case of follicular bronchiolitis associated with asthma, eosinophilia, and increased immunoglobulin E. (21039211)
2010
22
Neutrophil activation and protease imbalance in respiratory tract of infants with respiratory syncytial virus bronchiolitis]. (19567118)
2009
23
Fatal unmasking tuberculosis immune reconstitution disease with bronchiolitis obliterans organizing pneumonia: the role of macrophages. (19050399)
2009
24
Bronchiolitis obliterans organizing pneumonia. (19700963)
2009
25
Prognostic value of the 6min walk test in bronchiolitis obliterans syndrome. (19682883)
2009
26
Lung transplantation: the role of azithromycin in the management of patients with bronchiolitis obliterans syndrome. (18336286)
2008
27
Serum thymus and activation regulated chemokine levels post-lung transplantation as a predictor for the bronchiolitis obliterans syndrome. (18785972)
2008
28
Inducible costimulator blockade prolongs airway luminal patency in a mouse model of obliterative bronchiolitis. (19034015)
2008
29
Oxygen-sensitive 3He-MRI in bronchiolitis obliterans after lung transplantation. (17926041)
2008
30
Living-donor single-lobe lung transplantation for bronchiolitis obliterans in a 4-year-old boy. (17903555)
2007
31
Respiratory bronchiolitis-interstitial lung disease: long-term outcome. (17356078)
2007
32
T regulatory cells in stable posttransplant bronchiolitis obliterans syndrome. (17984845)
2007
33
Bronchial responsiveness to methacholine and adenosine 5'-monophosphate (AMP) in young children with post-infectious bronchiolitis obliterans. (16373297)
2006
34
Diagnosis of respiratory bronchiolitis associated interstitial lung disease. (16913580)
2006
35
Pulmonary melioidosis associated with bronchiolitis obliterans organizing pneumonia. (15603844)
2005
36
Bronchiolitis obliterans organizing pneumonia as an initial manifestation in systemic lupus erythematosus. (15880402)
2005
37
Bronchiolitis obliterans after allogenic bone marrow transplantation: HRCT findings. (15235235)
2004
38
The overlap between respiratory bronchiolitis and desquamative interstitial pneumonia in pulmonary Langerhans cell histiocytosis: high-resolution CT, histologic, and functional correlations. (14555547)
2003
39
Increased exhaled nitric oxide in bronchiolitis obliterans organizing pneumonia after allogeneic bone marrow transplantation. (12451281)
2002
40
Mechanisms of leukotriene D4-induced constriction in human small bronchioles. (11350860)
2001
41
Dermatomyositis without elevation of creatine kinase presented as bronchiolitis obliterans organizing pneumonia. (10714098)
2000
42
Eosinophilic granulocytes and interleukin-6 level in bronchoalveolar lavage fluid are associated with the development of obliterative bronchiolitis after lung transplantation. (11112142)
2000
43
Severe hypoxemia with orthodeoxia due to right to left shunt in idiopathic bronchiolitis obliterans organizing pneumonia]. (10756564)
2000
44
Atopic status and level of bronchial responsiveness in parents of children with acute bronchiolitis. (11192236)
2000
45
Pneumothorax complicating fatal bronchiolitis obliterans organizing pneumonia. (10364745)
1999
46
Differential effects of cyclosporin A and tacrolimus on the production of TGF-beta: implications for the development of obliterative bronchiolitis after lung transplantation. (9665007)
1998
47
Platelet-derived growth factor in bronchiolitis obliterans-organizing pneumonia. (9032212)
1997
48
Bronchiolitis obliterans organizing pneumonia (BOOP) in lung transplant recipients. (8915212)
1996
49
Bronchiolitis obliterans organizing pneumonia associated with massive L-tryptophan ingestion. (8252993)
1993
50
Low-dose/long-term erythromycin for treatment of bronchiolitis obliterans organizing pneumonia (BOOP). (8231065)
1993

Genetic Variations for Bronchiolitis

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Expression for genes affiliated with Bronchiolitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bronchiolitis

Search GEO for disease gene expression data for Bronchiolitis.

Pathways for genes affiliated with Bronchiolitis

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 59Tocris Bioscience
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Pathways related to Bronchiolitis according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3TLR4, PDGFB, BMP6, CXCR3, CXCL10, IL13
2
Hide members
11.2IL17A, IL13, CXCL10, CXCR3, PDGFB, TLR4
3
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11.2PDGFB, BMP6, CXCR3, CXCL10, IL13, IL8
4
Hide members
11.2IL8, IL13, CXCL10, CXCR3, BMP6, PDGFB
5
Hide members
11.0TLR4, IFNA2, CXCL10, IL13, IL8
6
Hide members
11.0IFNA2, PDGFB, BMP6, IL13, IL8
7
Hide members
10.9TLR4, IFNA2, CXCL10, IL8
8
Cytokine production by Th17 cells in CF (Mouse model)
10.8IL17A, IL8, TLR4
910.8CXCR3, CXCL10, IL8
1010.8IL8, CXCL10, TLR4
1110.8IFNA2, IL13, IL8
1210.8CXCL10, CXCR3, MAPKAP1
13
Hide members
10.8IL13, PIK3C2A, TLR4
1410.6TLR4

Compounds for genes affiliated with Bronchiolitis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Bronchiolitis according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1vegf4412.4PIK3C2A, MMP8, IL17A, IL13, CXCL10, CXCR3
2nitric oxide44 11 2414.3IL8, CXCR3, RNASE3, BMP6, SCGB1A1, PDGFB
3tyrosine4412.1IFNA2, TLR4, IL13, PDGFB, BMP6, PIK3C2A
4alanine4412.0SCGB1A1, BMP6, CXCL10, PIK3C2A, IFNA2, IL13
5lipid4412.0MMP8, IL17A, IFNA2, RNASE3, CHKA, PDGFB
6histamine44 28 2413.9IFNA2, HMOX1, BMP6, CXCR3, CXCL10, RNASE3
7lactate4411.9TLR4, MMP8, PIK3C2A, CHKA, RNASE3, IL13
8progesterone44 59 28 11 2415.9IFNA2, PDGFB, BMP6, CHKA, CXCR3, SCGB1A1
9phosphatidylinositol4411.9PIK3C2A, SCGB1A1, TLR4, CHKA, CXCR3, BMP6
10retinoic acid44 2412.8CHKA, BMP6, RNASE3, CXCL10, IL13, MMP8
11ly2940024411.8TLR4, BMP6, PIK3C2A, CXCR3, HMOX1, IL13
12superoxide44 2412.8MMP8, HMOX1, CXCR3, IL8, CHKA, PIK3C2A
13thymidine44 2412.8BMP6, PDGFB, IFNA2, CHKA, IL17A, CXCR3
14creatinine4411.8BMP6, IL17A, CXCR3, CXCL10, RNASE3, CHKA
15steroid4411.7IL17A, IL13, CXCR3, RNASE3, CHKA, PIK3C2A
16tacrolimus44 49 1113.7BMP6, CXCR3, TLR4, IL13, CXCL10, IL17A
17rantes4411.6CXCR3, RNASE3, MAPKAP1, BMP6, TLR4, IL17A
18cyclosporin a44 28 5913.6RNASE3, HMOX1, MMP8, PIK3C2A, IL17A, PDGFB
19dexamethasone44 49 28 1114.6RNASE3, TLR4, PDGFB, IL13, BMP6, CHKA
20il 104411.6TLR4, IL8, IL13, CXCL10, CXCR3, BMP6
21ifn-alpha4411.6TLR4, IFNA2, CXCR3, CXCL10, IL13, IL17A
22simvastatin44 49 59 28 11 2416.5IL8, HMOX1, CHKA, PIK3C2A, TLR4, BMP6
23groalpha4411.5CXCR3, IL17A, CXCL10, IL8, IL13
24infliximab44 49 1113.4IL17A, CXCR3, TLR4, CXCL10, IFNA2
25sb 20358044 5912.4BMP6, TLR4, IL13, IL8, IL17A, HMOX1
26ccl344 2812.4TLR4, CXCR3, CXCL10, IL13, IL8
27allergens4411.4IL13, CXCL10, CXCR3, RNASE3, TLR4
28oxygen44 2412.4PIK3C2A, IL8, MMP8, HMOX1, SCGB1A1
29sodium nitroprusside4411.4BMP6, IL13, HMOX1, PIK3C2A, CXCR3
30atorvastatin44 49 28 11 2415.3TLR4, BMP6, PIK3C2A, CHKA, HMOX1
31pd 98,0594411.3IL17A, IL8, IL13, CXCR3, BMP6, PDGFB
32imiquimod44 28 59 1114.3BMP6, TLR4, IL8, IFNA2
33endotoxin4411.3SCGB1A1, CXCR3, RNASE3
34hyaluronic acid44 2412.2IL8, BMP6, RNASE3, IL13, SCGB1A1
35fluticasone propionate44 49 59 1114.2RNASE3, IL13, IL8, CXCL10
36prednisolone44 28 1113.2RNASE3, IL13, IFNA2, PIK3C2A
37doxorubicin44 49 1113.2IL13, HMOX1, BMP6, PIK3C2A, CHKA, IFNA2
38aspartate4411.2SCGB1A1, CHKA, PIK3C2A, BMP6
39acetylcholine44 49 28 11 2415.2HMOX1, CHKA, BMP6
40etanercept44 49 1113.2IFNA2, CXCR3, IL8, IL17A
41methacholine44 1112.1IL8, IL17A, IL13, RNASE3
42h2o24411.1MMP8, IL13
43tarc4411.0IL8, IL13, CXCL10, CXCR3
44estrogen4411.0RNASE3
45ccl444 2811.9IL17A, CXCR3, CXCL10, IL13
46cycloheximide4410.9PDGFB, CXCL10
47hydrocortisone44 2 59 1113.8IL8
48formoterol44 28 1112.8IL8, IL13, RNASE3
49erythromycin44 49 2 1113.6IFNA2, PIK3C2A
50fmlp4410.5RNASE3, CXCR3, IL13

GO Terms for genes affiliated with Bronchiolitis

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16Gene Ontology
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Cellular components related to Bronchiolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.5HMOX1, IFNA2, PDGFB, SCGB1A1, BMP6, CXCL10
2extracellular regionGO:00557611.3MMP8, IL8, IL13, CXCL10, RNASE3, PDGFB
3external side of plasma membraneGO:00989710.7TLR4, CXCR3, CXCL10, IL13, IL17A

Biological processes related to Bronchiolitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.4IL17A, IFNA2, BMP6, CXCR3, CXCL10, IL13
2immune responseGO:00695511.3TLR4, BMP6, CXCL10, IL13, IL8, IL17A
3response to lipopolysaccharideGO:03249611.0TLR4, SCGB1A1, CXCL10, IL13
4signal transductionGO:00716510.9SCGB1A1, CHKA, CXCL10, IL13, IL8, RASSF6
5cell-cell signalingGO:00726710.8IFNA2, CXCL10, IL13, IL17A
6cellular component movementGO:00692810.8IL8, IL13, CXCR3
7positive regulation of smooth muscle cell proliferationGO:04866110.8HMOX1, IL13, PDGFB

Molecular functions related to Bronchiolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.9IL17A, IL13, BMP6, IFNA2

Products for genes affiliated with Bronchiolitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bronchiolitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet