MCID: BRN002
MIFTS: 61

Bronchiolitis malady

Summaries for Bronchiolitis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. it is caused by viruses and bacteria. the disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.

MalaCards: Bronchiolitis is related to bronchiolitis obliterans and pneumonia, and has symptoms including bluish skin due to lack of oxygen, nasal flaring in infants and fever. An important gene associated with Bronchiolitis is IL8 (interleukin 8), and among its related pathways are Akt Signaling and PEDF Induced Signaling. The compounds vegf and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and bone, and related mouse phenotypes are immune system and mortality/aging.

Wikipedia:63 Bronchiolitis is inflammation of the bronchioles, the smallest air passages of the lungs. It usually... more...

Aliases & Classifications for Bronchiolitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

bronchiolitis 8 10 44 60


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Disease Ontology8 DOID:2942
MeSH34 D001988
SNOMED-CT56 4120002
NCIt39 C39658

Related Diseases for Bronchiolitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bronchiolitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 252)
idRelated DiseaseScoreTop Affiliating Genes
1bronchiolitis obliterans31.9SCGB1A1, IL8, BMP6, MMP8, CXCR3, CXCL10
2pneumonia31.6IL8, TLR4, SCGB1A1, PIK3C2A, MMP8, IL13
3bronchiolitis obliterans organizing pneumonia31.5TOMM5
4asthma30.9IL13, RNASE3
5interstitial lung disease30.7IL8, PDGFB, BMP6
6cryptogenic organizing pneumonia30.6TOMM5
7rheumatoid arthritis30.5RNASE3, TLR4, BMP6, CXCR3, CXCL10, IL17A
8arthritis30.5IL13, CXCR3, IL8, CXCL10, MMP8, IL17A
9cystic fibrosis30.4HMOX1, SCGB1A1, TLR4, IL8, IL17A, RNASE3
10systemic lupus erythematosus30.4CXCL10, TLR4, IL17A, CXCR3
11leukemia30.3SCGB1A1, RNASE3, CXCR3, HMOX1, PDGFB, TLR4
12lung cancer30.3SCGB1A1, PDGFB, CHKA, MMP8, TLR4, CXCR3
13breast cancer30.2BMP6, SCGB1A1, HMOX1, CHKA, CXCR3, CXCL10
14ulcerative colitis30.2IL8, CXCR3, IL13, TLR4, RNASE3, IL17A
15respiratory failure30.2CXCL10, IL13, RNASE3, SCGB1A1
16eosinophilic pneumonia30.2IL13, RNASE3
17pulmonary fibrosis30.2PDGFB, IL8, CXCR3, BMP6, HMOX1, IL13
18sarcoidosis30.2SCGB1A1, CXCL10, CXCR3, IL13, PDGFB
19bronchitis30.2RNASE3
20tuberculosis30.1CXCL10, IL17A, PDGFB, CXCR3, TLR4
21hepatitis30.1IFNA2, CXCL10, PDGFB
22influenza30.1CXCL10, CXCR3
23eosinophilia29.9IFNA2, IL8, RNASE3, IL13, PIK3C2A
24ischemia29.9HMOX1, CHKA, PIK3C2A, PDGFB, IL17A
25hepatitis c29.9TLR4, CXCR3, IFNA2, CXCL10
26dermatomyositis29.9IL17A, PIK3C2A, CHKA
27bronchiectasis29.9MMP8, IL8, RNASE3
28pulmonary emphysema29.9HMOX1, MMP8
29idiopathic pulmonary fibrosis29.7IL8, CXCR3, CXCL10, BMP6, IL13, SCGB1A1
30pulmonary eosinophilia29.7IL8, RNASE3, IL13
31hepatitis b29.7IL17A, IFNA2, CXCL10
32myopathy29.7CHKA, PIK3C2A
33otitis media29.7RNASE3
34aspergillosis29.7TLR4
35cryoglobulinemia29.7IFNA2
36herpes simplex29.7CXCL10
37respiratory bronchiolitis-associated interstitial lung disease10.5
38pemphigus10.4
39nasopharyngitis10.3
40graft versus host disease10.3
41croup10.3
42desquamative interstitial pneumonia10.3
43lupus erythematosus10.3
44pneumothorax10.2
45diffuse panbronchiolitis10.2
46bronchiolitis obliterans with obstructive pulmonary disease10.2
47chronic eosinophilic pneumonia10.1
48bronchopneumonia10.1
49bronchial disease10.1
50stevens-johnson syndrome10.1

Graphical network of the top 20 diseases related to Bronchiolitis:



Diseases related to bronchiolitis

Clinical Features for Bronchiolitis

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8Disease Ontology
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Symptoms:

8
  • bluish skin due to lack of oxygen
  • nasal flaring in infants
  • fever
  • shortness of breath
  • wheezing
  • cough

Drugs & Therapeutics for Bronchiolitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bronchiolitis

Drug clinical trials:

Search ClinicalTrials for Bronchiolitis

Search NIH Clinical Center for Bronchiolitis

Search CenterWatch for Bronchiolitis

Genetic Tests for Bronchiolitis

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Anatomical Context for Bronchiolitis

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32MalaCards
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MalaCards organs/tissues related to Bronchiolitis:

32
Lung, Skin, Bone, Bone marrow, Breast, T cells, Colon, Liver, Heart, B cells, Testes, Thyroid, Trachea, Kidney, Smooth muscle, Thymus, Whole blood

Animal Models for Bronchiolitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bronchiolitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.9HMOX1, TLR4, PDGFB, SCGB1A1, PIK3C2A, TOMM5
2MP:001076811.8TLR4, PDGFB, SCGB1A1, PIK3C2A, TOMM5, CHKA
3MP:000537611.6PDGFB, SCGB1A1, PIK3C2A, CHKA, CXCR3, CXCL10
4MP:000539711.2TLR4, PDGFB, PIK3C2A, TOMM5, CXCL10, IL13
5MP:000536711.1TLR4, PDGFB, SCGB1A1, PIK3C2A, IL17A, HMOX1
6MP:000538810.9SCGB1A1, TOMM5, CXCR3

Publications for Bronchiolitis

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Sources:
50PubMed
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Articles related to Bronchiolitis:

(show top 50)    (show all 1202)
idTitleAuthorsYear
1
Chest health surveillance utility in the early detection of bronchiolitis obliterans syndrome in children after allo-SCT. (23165500)
2013
2
A relevant experimental model for human bronchiolitis obliterans syndrome. (24050896)
2013
3
Bronchoalveolar lavage fluid cytokine profiles in neuroendocrine cell hyperplasia of infancy and follicular bronchiolitis. (24216293)
2013
4
Severity scoring systems: are they internally valid, reliable and predictive of oxygen use in children with acute bronchiolitis? (22949369)
2013
5
Mechanical ventilation drives inflammation in severe viral bronchiolitis. (24349427)
2013
6
Vitamin D receptor (VDR) polymorphisms and severe RSV bronchiolitis: A systematic review and meta-analysis. (24019226)
2013
7
Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. (24163409)
2013
8
Aspiration, localized pulmonary inflammation, and predictors of early-onset bronchiolitis obliterans syndrome after lung transplantation. (23628225)
2013
9
On-demand, not scheduled, nebulization (epinephrine or saline) improves important clinical outcomes in hospitalized infants with bronchiolitis. (24160663)
2013
10
Chest physical therapy in acute viral bronchiolitis: an updated review. (23287014)
2013
11
Bronchiolitis obliterans syndrome is associated with increased peripheral blood natural killer and natural killer T-like granzymes, perforin, and T-helper-type 1 pro-inflammatory cytokines. (22759800)
2012
12
Surfactant therapy for bronchiolitis in critically ill infants. (22972138)
2012
13
Increased plasma mannose binding lectin levels are associated with bronchiolitis obliterans after lung transplantation. (22762710)
2012
14
Time to explore preventive and novel therapies for bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation. (22449611)
2012
15
A potent anti-angiogenic factor, vasohibin-1, ameliorates experimental bronchiolitis obliterans. (22564651)
2012
16
A prospective interventional study on the use of extracorporeal photopheresis in patients with bronchiolitis obliterans syndrome after lung transplantation. (22884382)
2012
17
Use of continuous positive airway pressure (CPAP) in acute viral bronchiolitis: a systematic review. (21618716)
2011
18
Factors predicting prolonged hospital stay for infants with bronchiolitis. (21661099)
2011
19
A genetic polymorphism in the CAV1 gene associates with the development of bronchiolitis obliterans syndrome after lung transplantation. (22040717)
2011
20
Exhaled nitric oxide in diagnosis of bronchiolitis obliterans syndrome in lung transplant recipients: possible limitations. (22054303)
2011
21
Clara cell secretory protein and surfactant protein-D do not predict bronchiolitis obliterans syndrome after lung transplantation. (20683434)
2010
22
An unwelcome guest: Aspergillus colonization in lung transplantation and its association with bronchiolitis obliterans syndrome. (19538485)
2009
23
Matrilysin-1 mediates bronchiolization of alveoli, a potential premalignant change in lung cancer. (19608871)
2009
24
Popcorn lung and bronchiolitis obliterans: a critical appraisal. (18548268)
2009
25
Onset of bronchiolitis obliterans organizing pneumonia in a liver transplant recipient under peg-interferon and ribavirin treatment. (18256887)
2008
26
Unusual manifestation of bronchiolitis obliterans organizing pneumonia. (18807607)
2008
27
Occupational bronchiolitis obliterans masquerading as COPD. (17715381)
2007
28
Paraneoplastic Pemphigus and Bronchiolitis Obliterans in a Patient with Splenic B-cell Lymphoma. (17908666)
2007
29
CD14 -550 C/T, which is related to the serum level of soluble CD14, is associated with the development of respiratory syncytial virus bronchiolitis in the Japanese population. (17471431)
2007
30
Fatal outcome of generalized morphoea with bronchiolitis obliterans organizing pneumonia. (16901325)
2006
31
Postinfectious bronchiolitis obliterans accompanied by pulmonary hemosiderosis in childhood. (17435911)
2006
32
Lower incidence of Bronchiolitis obliterans in allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning compared with myeloablative conditioning. (15852024)
2005
33
Bronchiolitis obliterans organising pneumonia: a treatable condition. (16114165)
2005
34
Bronchiolitis obliterans organizing pneumonia. Clinical and roentgenological features in 26 cases. (15942294)
2005
35
Matrix metalloproteinase-9 in bronchiolitis obliterans syndrome after lung transplantation. (15738294)
2005
36
Constrictive bronchiolitis obliterans in patient with Castelman's disease. (16454222)
2005
37
Dynamic high-resolution electron-beam CT scanning for the diagnosis of bronchiolitis obliterans syndrome after lung transplantation. (15302730)
2004
38
Bronchiolitis obliterans organizing pneumonia as a manifestation of AIDS: case report and literature review. (15236924)
2004
39
Spontaneous pneumothorax developed in patients with bronchiolitis obliterans after unrelated hematopoietic stem cell transplantation: case report and review of the literature. (15168602)
2004
40
Respiratory bronchiolitis-associated interstitial lung disease: radiologic features with clinical and pathologic correlation. (11801899)
2002
41
Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. (11083887)
2000
42
Bronchiolitis obliterans. (16088726)
2000
43
Dermatomyositis associated with bronchiolitis obliterans organizing pneumonia (BOOP). (10025861)
1999
44
Expression of inducible nitric oxide synthase and formation of peroxynitrite in posttransplant obliterative bronchiolitis. (9703237)
1998
45
Bronchiolitis obliterans organizing pneumonia and ulcerative colitis after allogeneic bone marrow transplantation. (9613791)
1998
46
Recent advances in the treatment of bronchiolitis and laryngitis. (9057793)
1997
47
Cryptogenic constrictive bronchiolitis imitating imaging features of diffuse panbronchiolitis. (7613542)
1995
48
Bronchiolitis obliterans: the lone manifestation of rheumatoid arthritis? (8005266)
1994
49
Bronchiolitis obliterans organizing pneumonia: CT features in 14 patients. (2108572)
1990
50
HIV-associated bronchiolitis obliterans organizing pneumonia. (2736975)
1989

Genetic Variations for Bronchiolitis

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Expression for genes affiliated with Bronchiolitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bronchiolitis

Search GEO for disease gene expression data for Bronchiolitis.

Pathways for genes affiliated with Bronchiolitis

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 59Tocris Bioscience
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Pathways related to Bronchiolitis according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.3TLR4, PDGFB, BMP6, CXCR3, CXCL10, IL13
2
Hide members
11.2IL17A, IL13, CXCL10, CXCR3, PDGFB, TLR4
3
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11.2PDGFB, BMP6, CXCR3, CXCL10, IL13, IL8
4
Hide members
11.2IL8, IL13, CXCL10, CXCR3, BMP6, PDGFB
5
Hide members
11.0TLR4, IFNA2, CXCL10, IL13, IL8
6
Hide members
11.0IFNA2, PDGFB, BMP6, IL13, IL8
7
Hide members
10.9TLR4, IFNA2, CXCL10, IL8
8
Cytokine production by Th17 cells in CF (Mouse model)
10.8IL17A, IL8, TLR4
910.8CXCR3, CXCL10, IL8
1010.8IL8, CXCL10, TLR4
1110.8IFNA2, IL13, IL8
1210.8CXCL10, CXCR3, MAPKAP1
13
Hide members
10.8IL13, PIK3C2A, TLR4
1410.6TLR4

Compounds for genes affiliated with Bronchiolitis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Bronchiolitis according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1vegf4412.4HMOX1, TLR4, IFNA2, PDGFB, BMP6, PIK3C2A
2nitric oxide44 11 2414.3TLR4, PDGFB, SCGB1A1, BMP6, RNASE3, CXCR3
3tyrosine4412.1TLR4, IFNA2, PDGFB, BMP6, PIK3C2A, CHKA
4alanine4412.0TLR4, IFNA2, SCGB1A1, BMP6, PIK3C2A, CHKA
5lipid4412.0TLR4, IFNA2, PDGFB, SCGB1A1, PIK3C2A, CHKA
6histamine44 28 2413.9TLR4, IFNA2, BMP6, RNASE3, CXCR3, CXCL10
7lactate4411.9TLR4, BMP6, PIK3C2A, CHKA, RNASE3, IL13
8progesterone44 59 28 11 2415.9IFNA2, PDGFB, SCGB1A1, BMP6, PIK3C2A, CHKA
9phosphatidylinositol4411.9TLR4, SCGB1A1, BMP6, PIK3C2A, CHKA, CXCR3
10retinoic acid44 2412.8TLR4, IFNA2, BMP6, CHKA, RNASE3, CXCL10
11ly2940024411.8TLR4, BMP6, PIK3C2A, CXCR3, IL13, IL8
12superoxide44 2412.8TLR4, IFNA2, PIK3C2A, CHKA, CXCR3, IL8
13thymidine44 2412.8IFNA2, PDGFB, BMP6, CHKA, CXCR3, CXCL10
14creatinine4411.8SCGB1A1, BMP6, PIK3C2A, CHKA, RNASE3, CXCR3
15steroid4411.7IFNA2, SCGB1A1, PIK3C2A, CHKA, RNASE3, CXCR3
16tacrolimus44 49 1113.7TLR4, PDGFB, BMP6, CXCR3, CXCL10, IL13
17rantes4411.6TLR4, BMP6, MAPKAP1, RNASE3, CXCR3, IL17A
18cyclosporin a44 28 5913.6PDGFB, PIK3C2A, RNASE3, IL17A, MMP8, HMOX1
19dexamethasone44 49 28 1114.6TLR4, PDGFB, BMP6, CHKA, RNASE3, IL13
20il 104411.6TLR4, BMP6, CXCR3, CXCL10, IL13, IL8
21ifn-alpha4411.6TLR4, IFNA2, CXCR3, CXCL10, IL13, IL17A
22simvastatin44 49 59 28 11 2416.5TLR4, BMP6, PIK3C2A, CHKA, IL8, HMOX1
23groalpha4411.5CXCR3, CXCL10, IL13, IL8, IL17A
24infliximab44 49 1113.4TLR4, IFNA2, CXCR3, CXCL10, IL17A
25sb 20358044 5912.4TLR4, BMP6, IL13, IL8, IL17A, HMOX1
26ccl344 2812.4TLR4, CXCR3, CXCL10, IL13, IL8
27allergens4411.4TLR4, RNASE3, CXCR3, CXCL10, IL13
28oxygen44 2412.4SCGB1A1, PIK3C2A, IL8, MMP8, HMOX1
29sodium nitroprusside4411.4BMP6, PIK3C2A, CXCR3, IL13, HMOX1
30atorvastatin44 49 28 11 2415.3TLR4, BMP6, PIK3C2A, CHKA, HMOX1
31pd 98,0594411.3PDGFB, BMP6, CXCR3, IL13, IL8, IL17A
32imiquimod44 28 59 1114.3TLR4, IFNA2, BMP6, IL8
33endotoxin4411.3SCGB1A1, RNASE3, CXCR3
34hyaluronic acid44 2412.2IL8, IL13, RNASE3, BMP6, SCGB1A1
35fluticasone propionate44 49 59 1114.2IL8, IL13, CXCL10, RNASE3
36prednisolone44 28 1113.2IFNA2, PIK3C2A, RNASE3, IL13
37doxorubicin44 49 1113.2HMOX1, IL13, CHKA, PIK3C2A, BMP6, IFNA2
38aspartate4411.2SCGB1A1, BMP6, PIK3C2A, CHKA
39acetylcholine44 49 28 11 2415.2BMP6, CHKA, HMOX1
40etanercept44 49 1113.2IL17A, IL8, CXCR3, IFNA2
41methacholine44 1112.1IL17A, IL8, IL13, RNASE3
42h2o24411.1IL13, MMP8
43tarc4411.0CXCR3, CXCL10, IL13, IL8
44estrogen4411.0RNASE3
45ccl444 2811.9IL17A, IL13, CXCL10, CXCR3
46cycloheximide4410.9PDGFB, CXCL10
47hydrocortisone44 2 59 1113.8IL8
48formoterol44 28 1112.8RNASE3, IL13, IL8
49erythromycin44 49 2 1113.6PIK3C2A, IFNA2
50fmlp4410.5RNASE3, CXCR3, IL13

GO Terms for genes affiliated with Bronchiolitis

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16Gene Ontology
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Cellular components related to Bronchiolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.5HMOX1, IFNA2, PDGFB, SCGB1A1, BMP6, CXCL10
2extracellular regionGO:00557611.3MMP8, IL8, IL13, CXCL10, RNASE3, PDGFB
3external side of plasma membraneGO:00989710.7TLR4, CXCR3, CXCL10, IL13, IL17A

Biological processes related to Bronchiolitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.4IL17A, IFNA2, BMP6, CXCR3, CXCL10, IL13
2immune responseGO:00695511.3TLR4, BMP6, CXCL10, IL13, IL8, IL17A
3response to lipopolysaccharideGO:03249611.0TLR4, SCGB1A1, CXCL10, IL13
4signal transductionGO:00716510.9SCGB1A1, CHKA, CXCL10, IL13, IL8, RASSF6
5cell-cell signalingGO:00726710.8IFNA2, CXCL10, IL13, IL17A
6cellular component movementGO:00692810.8IL8, IL13, CXCR3
7positive regulation of smooth muscle cell proliferationGO:04866110.8HMOX1, IL13, PDGFB

Molecular functions related to Bronchiolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.9IL17A, IL13, BMP6, IFNA2

Products for genes affiliated with Bronchiolitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bronchiolitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet