MCID: BRN002
MIFTS: 61

Bronchiolitis malady

Respiratory diseases category
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Summaries for Bronchiolitis

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Disease Ontology:8 A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. it is caused by viruses and bacteria. the disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.

MalaCards based summary: Bronchiolitis is related to bronchiolitis obliterans organizing pneumonia and asthma, and has symptoms including An important gene associated with Bronchiolitis is IL8 (interleukin 8), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and Cytokine production by Th17 cells in CF. The compounds formoterol and fluticasone propionate have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and bone, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Wikipedia:65 Bronchiolitis is inflammation of the bronchioles, the smallest air passages of the lungs. It usually... more...

Aliases & Classifications for Bronchiolitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
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Bronchiolitis, Aliases & Descriptions:

Name: Bronchiolitis 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:2942
NCIt39 C39658
SNOMED-CT57 4120002
MeSH34 D001988

Related Diseases for Bronchiolitis

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Diseases related to Bronchiolitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1bronchiolitis obliterans organizing pneumonia32.5TOMM5
2asthma31.6RNASE3, IL13
3cryptogenic organizing pneumonia31.5TOMM5
4bronchiolitis obliterans31.3SCGB1A1, MMP8, CXCL10, CXCR3, IL17A, IL8
5interstitial lung disease31.2IL8, PDGFB
6arthritis31.1IL8, IL17A
7eosinophilic pneumonia30.9RNASE3, IL13
8bronchitis30.8RNASE3, IL8
9respiratory failure30.6SCGB1A1, RNASE3, CXCL10, IL13
10bronchiectasis30.6RNASE3, MMP8, IL8
11bronchopulmonary dysplasia30.6SCGB1A1, RNASE3, IL8
12malaria30.5ALB
13pneumonia30.4TLR4, SCGB1A1, MMP8, HMOX1, CRP, IL13
14pulmonary emphysema30.4HMOX1, MMP8
15colitis30.4TLR4, CXCL10, IL17A, IL8, IL13
16extrinsic allergic alveolitis30.4IL8, CXCR3
17pulmonary eosinophilia30.3RNASE3, IL8, IL13
18hepatitis30.3CXCL10, IFNA2, PDGFB
19eosinophilia30.3IL13, IL8, IFNA2, RNASE3
20sarcoidosis30.2SCGB1A1, CXCL10, CXCR3, IL13, PDGFB
21lung cancer30.1TLR4, SCGB1A1, MMP8, CXCR3, PDGFB
22systemic lupus erythematosus30.1TLR4, CXCL10, CXCR3, IL17A, CRP
23hepatitis c30.1TLR4, CXCL10, CXCR3, IFNA2
24pulmonary sarcoidosis30.1PDGFB, CXCR3
25atopy30.0TLR4, SCGB1A1, RNASE3, CXCR3, IL13
26coronary artery anomaly30.0TLR4, MMP8, CRP
27pulmonary fibrosis29.9CXCR3, IL8, IL13, PDGFB, HMOX1
28cystic fibrosis29.8TLR4, SCGB1A1, RNASE3, IL17A, IL8, ALB
29ankylosing spondylitis29.8CRP, IL17A, TLR4
30breast cancer29.7SCGB1A1, MMP8, CXCL10, CXCR3, IL17A, ALB
31hepatitis b29.7TLR4, CXCL10, IFNA2, ALB
32idiopathic pulmonary fibrosis29.6SCGB1A1, CXCL10, CXCR3, IL8, IL13, PDGFB
33rheumatoid arthritis29.5TLR4, RNASE3, MMP8, CXCL10, CXCR3, IL17A
34leukemia29.5TLR4, SCGB1A1, RNASE3, CXCR3, IFNA2, IL17A
35ulcerative colitis29.4TLR4, RNASE3, CXCL10, CXCR3, IL17A, IL8
36congenital heart disease29.2HMOX1, CRP, ALB, TLR4
37tuberculosis29.2TLR4, CXCL10, CXCR3, IL17A, ALB, PDGFB
38chronic obstructive pulmonary disease28.5SCGB1A1, RNASE3, MMP8, CXCL10, CXCR3, IL17A
39hematopoietic stem cell transplantation10.7
40funisitis10.6MMP8
41conjunctivitis10.5RNASE3
42respiratory bronchiolitis-associated interstitial lung disease10.5
43common cold10.5IL8, RNASE3
44polyarteritis nodosa10.5IFNA2
45sinusitis10.5RNASE3
46pemphigus10.5
47paraneoplastic pemphigus10.5
48helminthiasis10.4IL13, RNASE3
49gastroenteritis10.4PDGFB
50allergic conjunctivitis10.4RNASE3, IL13

Graphical network of the top 20 diseases related to Bronchiolitis:



Diseases related to bronchiolitis

Symptoms for Bronchiolitis

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Drugs & Therapeutics for Bronchiolitis

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Drug clinical trials:

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Search NIH Clinical Center for Bronchiolitis

Genetic Tests for Bronchiolitis

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Anatomical Context for Bronchiolitis

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MalaCards organs/tissues related to Bronchiolitis:

32
Lung, Skin, Bone, Bone marrow, Breast, T cells, Colon, Neutrophil, Liver, Heart, B cells, Testes, Kidney, Thyroid, Trachea, Whole blood, Thymus, Smooth muscle

Animal Models for Bronchiolitis or affiliated genes

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MGI Mouse Phenotypes related to Bronchiolitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4TLR4, SCGB1A1, MMP8, CXCR3, ALB
2MP:00053678.1TLR4, SCGB1A1, CXCR3, IL17A, ALB, PDGFB
3MP:00053887.9TLR4, SCGB1A1, TOMM5, CXCR3, IL17A, IL13
4MP:00053847.8HMOX1, ALB, MAPKAP1, IL13, CXCR3, CXCL10
5MP:00053857.6TLR4, TOMM5, CXCL10, CXCR3, PDGFB, CRP
6MP:00053977.6TLR4, TOMM5, CXCL10, CXCR3, IL17A, IL8
7MP:00053766.8TLR4, SCGB1A1, CXCL10, CXCR3, IL17A, IL13
8MP:00053876.7HMOX1, TLR4, SCGB1A1, MMP8, TOMM5, CXCL10
9MP:00107686.6TLR4, SCGB1A1, TOMM5, CXCL10, CXCR3, IL17A

Publications for Bronchiolitis

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Articles related to Bronchiolitis:

(show top 50)    (show all 1229)
idTitleAuthorsYear
1
Effects of prophylactic use of sirolimus on bronchiolitis obliterans syndrome development in lung transplant recipients. (24119986)
2014
2
Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans. (24820310)
2014
3
Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study. (24852165)
2014
4
Club cell secretory protein improves survival in a murine obliterative bronchiolitis model. (23997179)
2013
5
Aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans. (23062110)
2013
6
Chest health surveillance utility in the early detection of bronchiolitis obliterans syndrome in children after allo-SCT. (23165500)
2013
7
Variation and trends in ED use of radiographs for asthma, bronchiolitis, and croup in children. (23878045)
2013
8
A relevant experimental model for human bronchiolitis obliterans syndrome. (24050896)
2013
9
Risk factors for bronchiolitis obliterans syndrome in allogeneic hematopoietic stem cell transplantation. (23823823)
2013
10
HIV-associated follicular bronchiolitis. (23947519)
2013
11
Occupational causes of constrictive bronchiolitis. (23407121)
2013
12
Better newborn vitamin D status lowers RSV-associated bronchiolitis in infants. (22946854)
2012
13
Impact of a bronchiolitis clinical care pathway on treatment and hospital stay. (22193364)
2012
14
Nasopharyngeal airway pressures in bronchiolitis patients treated with high-flow nasal cannula oxygen therapy. (23114244)
2012
15
Rapid acute onset of bronchiolitis obliterans syndrome in a lung transplant recipient after respiratory syncytial virus infection. (22650803)
2012
16
Bronchiolitis obliterans syndrome is associated with increased peripheral blood natural killer and natural killer T-like granzymes, perforin, and T-helper-type 1 pro-inflammatory cytokines. (22759800)
2012
17
Clinical predictors of nasal continuous positive airway pressure requirement in acute bronchiolitis. (21901857)
2012
18
Current therapy for bronchiolitis. (22734014)
2012
19
Serum levels of lipoxin A(4) do not predict the development of subsequent asthma among young children with acute bronchiolitis. (21671842)
2011
20
Bronchiolitis obliterans in children: a ghostly journey to the origin. (21872382)
2011
21
Ingraft chimerism in lung transplantation--a study in a porcine model of obliterative bronchiolitis. (21521503)
2011
22
Household tobacco smoke and admission weight predict severe bronchiolitis in infants independent of deprivation: prospective cohort study. (21811609)
2011
23
Breathing easy: implementing a bronchiolitis protocol. (21739745)
2011
24
Helium-oxygen therapy for infants with bronchiolitis: a randomized controlled trial. (22147778)
2011
25
HBs seroconversion in a patient with acute hepatitis B treated with entecavir during immunosuppression against severe bronchiolitis obliterans in the course of chronic graft versus host disease. (20403727)
2010
26
Local IL-17 production and a decrease in peripheral blood regulatory T cells in an animal model of bronchiolitis obliterans. (20393404)
2010
27
The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation. (20456980)
2010
28
Systemic and exhaled cytokine and chemokine profiles are associated with the development of bronchiolitis obliterans syndrome. (20627628)
2010
29
Air-leak and transient coronary artery dilation in post-infectious bronchiolitis obliterans. (20958871)
2010
30
The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation. (19299743)
2009
31
Effect of maintenance azithromycin on established bronchiolitis obliterans syndrome in lung transplant patients. (18551201)
2008
32
Neutrophil but not eosinophil inflammation is related to the severity of a first acute epidemic bronchiolitis in young infants. (18093085)
2008
33
Soluble CD30 levels as a diagnostic marker for bronchiolitis obliterans syndrome following human lung transplantation. (18047935)
2008
34
Bronchiolitis obliterans syndrome: alloimmune-dependent and -independent injury with aberrant tissue remodeling. (18707652)
2008
35
Respiratory bronchiolitis-associated interstitial lung disease in a nonsmoker: radiologic and pathologic findings. (17449735)
2007
36
Lung transplantation in the Fischer 344-->Wistar Kyoto rat strain combination is not suitable to study bronchiolitis obliterans. (17403482)
2007
37
Cytokines in the nasal washes of children with respiratory syncytial virus bronchiolitis. (16569362)
2006
38
Fatal coronary artery anomaly presenting as bronchiolitis. (16602012)
2006
39
Genetic variation at the IL10 gene locus is associated with severity of respiratory syncytial virus bronchiolitis. (15838798)
2005
40
The incidence and clinical characteristics of bronchiolitis obliterans organizing pneumonia syndrome after radiation therapy for breast cancer. (15554078)
2004
41
Solitary nodular form of bronchiolitis obliterans organizing pneumonia. (15589500)
2004
42
A case of bronchiolitis obliterans organizing pneumonia syndrome with preceding radiation pneumonitis after breast-conserving therapy. (15640508)
2004
43
Bronchiolitis obliterans organizing pneumonia associated with sulfasalazine in a patient with rheumatoid arthritis. (15168156)
2004
44
Enhanced IL-4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy. (12212970)
2002
45
Bronchiolitis obliterans organizing pneumonia associated with Evans syndrome. (11786723)
2001
46
Bronchiolitis obliterans organizing pneumonia. Trying to answer an intriguing question. (11185490)
2000
47
Platelet-derived growth factor in bronchiolitis obliterans-organizing pneumonia. (9032212)
1997
48
Bronchiolitis obliterans organizing pneumonia associated with systemic lupus erythematosus with antiphospholipid antibody. (8739795)
1996
49
Bronchiolitis obliterans in a patient with localized scleroderma treated with D-penicillamine. (8804954)
1996
50
Chronic eosinophilic pneumonia and idiopathic bronchiolitis obliterans organizing pneumonia: comparison of eosinophil number and degranulation by immunofluorescence staining for eosinophil-derived major basic protein. (7531262)
1995

Variations for Bronchiolitis

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Expression for genes affiliated with Bronchiolitis

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Expression patterns in normal tissues for genes affiliated with Bronchiolitis

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Pathways for genes affiliated with Bronchiolitis

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Pathways related to Bronchiolitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7CXCL10, IL8, CXCR3
2
Show member pathways
9.7IL17A, TLR4, IL8
39.7IL17A, IL8, TLR4
49.6IL8, IFNA2, IL13
5
Show member pathways
9.6IL8, IFNA2, CXCL10
69.6TLR4, CXCL10, IL8
7
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.6TLR4, IL8, CXCL10
8
Show member pathways
9.6IL13, TLR4, IL17A
99.5CXCL10, CXCR3, MAPKAP1
10
Show member pathways
9.5CXCL10, CXCR3, MMP8, IL8
119.4ALB, MMP8, SCGB1A1
12
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.2IL8, IFNA2, CXCL10, TLR4
13
Show member pathways
9.1CXCR3, CXCL10, IL13, IL8, PDGFB
14
Show member pathways
9.1PDGFB, CXCL10, CXCR3, IL8, IL13
15
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1TLR4, IFNA2, IL8, HMOX1
16
Show member pathways
9.0IL8, TLR4, CXCL10, IL13, IFNA2
17
Show member pathways
8.7CXCL10, TLR4, PDGFB, CXCR3, IL8, IL13
18
Show member pathways
8.1IL8, IL13, PDGFB, IFNA2, CXCR3, IL17A

Compounds for genes affiliated with Bronchiolitis

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Compounds related to Bronchiolitis according to GeneCards/GeneDecks:

(show top 50)    (show all 149)
idCompoundScoreTop Affiliating Genes
1formoterol44 28 1112.0IL13, IL8, RNASE3
2fluticasone propionate44 50 61 1112.8RNASE3, IL13, CXCL10, IL8
3salmeterol44 50 28 1112.8IL8, IL13, RNASE3
4tarc449.7CXCL10, IL13, IL8, CXCR3
5ccl444 2810.7IL13, CXCL10, CXCR3, IL17A
6groalpha449.6IL8, CXCL10, IL17A, CXCR3, IL13
7fmlp449.5TLR4, IL13, IL8, CXCR3, RNASE3
8il 10449.4TLR4, IL8, CXCR3, CXCL10, IL13
9ccl344 2810.4CXCR3, TLR4, IL13, IL8, CXCL10
10allergens449.4TLR4, CXCL10, CXCR3, RNASE3, IL13
11methacholine44 50 1111.4RNASE3, IL17A, IL8, IL13, CRP
12p002449.4SCGB1A1, CRP, IL17A, MMP8, RNASE3
13neopterin449.3CRP, CXCL10, IFNA2, IL8
14etanercept44 50 1111.3IL8, IL17A, IFNA2, CRP, CXCR3
15gamma globulin449.3IFNA2, ALB, CRP
16hyaluronic acid44 2410.2SCGB1A1, RNASE3, ALB, IL8, IL13
17ifn-alpha449.1CXCL10, CXCR3, IFNA2, IL17A, TLR4, IL13
18thymidine44 2410.0PDGFB, IL13, CXCR3, IFNA2, IL17A, CXCL10
19aspirin44 50 28 2411.9CRP, HMOX1, IL13, RNASE3, TLR4
20superoxide44 249.9IL8, IFNA2, MMP8, HMOX1, TLR4, CXCR3
21infliximab44 50 1110.9TLR4, CXCL10, CXCR3, IFNA2, IL17A, CRP
22chloramphenicol44 2 50 1111.8CRP, PDGFB, IL13, SCGB1A1, HMOX1
23prednisolone44 28 1110.8IL13, ALB, IFNA2, CRP, RNASE3
24n acetylcysteine448.8HMOX1, CRP, IL8, RNASE3, TLR4
25sb 20358044 619.8CRP, IL13, IL8, IL17A, TLR4, HMOX1
26vitamin a44 24 1110.7ALB, IL13, SCGB1A1, IFNA2, CRP
27alpha tocopherol448.6IFNA2, IL13, HMOX1, CRP, ALB
28rantes448.6CXCL10, TLR4, RNASE3, IL13, IL8, IL17A
29cyclosporin a44 28 6110.6TLR4, RNASE3, HMOX1, PDGFB, IL13, IL8
30oxygen44 249.5MMP8, SCGB1A1, CXCR3, IFNA2, IL8, PDGFB
31indomethacin44 28 61 1111.5IFNA2, IL17A, HMOX1, IL13, ALB
32ly294002448.5HMOX1, CRP, IL13, CXCR3, TLR4, IL17A
33tacrolimus44 50 1110.5CXCR3, IL17A, TLR4, IL13, ALB, PDGFB
34polyethylene glycol448.4IFNA2, HMOX1, CRP, ALB
35creatinine448.4ALB, CXCL10, RNASE3, SCGB1A1, CXCR3, CRP
36cycloheximide448.4HMOX1, CXCL10, IL8, IL13, PDGFB, TLR4
37retinoic acid44 249.3HMOX1, IL13, IFNA2, CXCL10, MMP8, TLR4
38pge2448.3HMOX1, TLR4, RNASE3, MMP8, CXCL10, CXCR3
39aspartate448.3IL13, SCGB1A1, IFNA2, TLR4, ALB, CRP
40endotoxin448.3CRP, IL13, IL8, IL17A, CXCR3, CXCL10
41dexamethasone44 50 28 1111.2IL13, IL17A, CXCL10, TLR4, PDGFB, HMOX1
42iron44 249.2HMOX1, TLR4, CRP, ALB, IFNA2, SCGB1A1
43estrogen448.2SCGB1A1, RNASE3, CXCL10, IFNA2, IL17A, IL13
44lactate448.0TLR4, RNASE3, IL13, MMP8, IL8, ALB
45histamine44 28 249.8HMOX1, ALB, CXCL10, IL8, IFNA2, CXCR3
46nitric oxide44 24 119.8TLR4, SCGB1A1, RNASE3, MMP8, CXCR3, IL17A
47cysteine447.7HMOX1, TLR4, MMP8, IFNA2, IL8, IL13
48alanine447.5HMOX1, CRP, ALB, IL13, IFNA2, CXCL10
49lipid447.5PDGFB, CRP, SCGB1A1, RNASE3, MMP8, CXCL10
50vegf447.2HMOX1, TLR4, RNASE3, MMP8, CRP, PDGFB

GO Terms for genes affiliated with Bronchiolitis

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Cellular components related to Bronchiolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0IL13, IL17A, CXCR3, CXCL10, TLR4
2extracellular regionGO:0055767.1RNASE3, MMP8, CXCL10, IFNA2, IL8, IL13
3extracellular spaceGO:0056156.6HMOX1, SCGB1A1, MMP8, CXCL10, IFNA2, IL17A

Biological processes related to Bronchiolitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:03081610.1CXCR3, CXCL10
2T cell chemotaxisGO:01081810.1CXCR3, CXCL10
3positive regulation of chemotaxisGO:05092110.0PDGFB, CXCR3
4positive regulation of cAMP-mediated signalingGO:04395010.0CXCR3, CXCL10
5positive regulation of release of sequestered calcium ion into cytosolGO:0512819.9IL13, CXCR3, CXCL10
6cellular component movementGO:0069289.9CXCR3, IL8, IL13
7negative regulation of interferon-gamma productionGO:0326899.8SCGB1A1, TLR4
8chemotaxisGO:0069359.8CXCL10, CXCR3, IL8
9positive regulation of smooth muscle cell proliferationGO:0486619.7IL13, PDGFB, HMOX1
10response to lipopolysaccharideGO:0324969.5TLR4, SCGB1A1, CXCL10, IL13
11cell-cell signalingGO:0072679.5CXCL10, IFNA2, IL17A, IL13
12cell surface receptor signaling pathwayGO:0071669.5CXCL10, CXCR3, IFNA2
13response to nicotineGO:0350949.4HMOX1, IL13
14immune responseGO:0069559.3IL13, IL8, IL17A, CXCL10, TLR4
15inflammatory responseGO:0069548.6CRP, CXCL10, CXCR3, IFNA2, IL17A, IL8
16signal transductionGO:0071658.6RASSF6, IL13, IL8, CXCL10, SCGB1A1

Molecular functions related to Bronchiolitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.6IL13, IL17A, IFNA2
2protein bindingGO:0055155.7RASSF6, TLR4, SCGB1A1, CXCL10, IFNA2, IL8

Products for genes affiliated with Bronchiolitis

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Sources for Bronchiolitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet