Bronchiolitis malady

Disease Ontology: A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. it is caused by viruses and bacteria. the disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.⁶

MalaCards: Bronchiolitis is related to bronchiolitis obliterans and bronchiolitis obliterans organizing pneumonia, and has symptoms including cough, wheezing and shortness of breath. An important gene associated with Bronchiolitis is IL8 (interleukin 8), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and PGC1Alpha Pathway. The compounds peptidoglycan and allergens have been mentioned in the context of this disorder. Affiliated tissues include whole blood, thymus and heart, and related mouse phenotypes are hematopoietic system and respiratory system.

Wikipedia: Bronchiolitis is inflammation of the bronchioles, the smallest air passages of the lungs. It usually...⁴⁴ more...

Aliases & Descriptions:

bronchiolitis 6 8 32 43

Diseases related to bronchiolitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 869)

id	Related Disease	Score	Top Affiliating Genes
1	bronchiolitis obliterans	41.9	ZNF33A, PIK3C2A, KIR2DS5, KIR3DL1, SFTPA1, SFTPD
2	bronchiolitis obliterans organizing pneumonia	34.6	PIK3C2A, UNC119, CHKA, FHOD1, MAPKAP1, IFNA2
3	pneumonia	34.3	PIK3C2A, SFTPA1, SFTPB, SFTPC, SFTPD, SELE
4	asthma	34.0	SCGB1A1, IL12B, IL13, CCL11, HNMT, TNF
5	diffuse panbronchiolitis	31.6	MUC5AC, MUC5B, MUC7, MPO, CD79A, IL13
6	panbronchiolitis	31.6	MUC5AC, MUC5B, MUC7, MPO, CD79A, IL13
7	measles	30.9	SFTPD, SELE, VCAM1, CHUK, JAK1, JAK2
8	atopy	30.8	KITLG, VDR, SCGB1A1, MS4A2, MPO, JAK1
9	polymyositis	30.5	PIK3C2A, SFTPD, SELE, VCAM1, CHKA, CHKB
10	bronchial asthma	30.3	KITLG, SFTPD, SELE, SELL, VIP, VCAM1
11	influenza	29.9	PIK3C2A, SFTPA1, SFTPD, SELL, MUC2, MUC5AC
12	extrinsic allergic alveolitis	29.4	SFTPD, CD14, CD80, FCER2, IL18, IL1A
13	arthritis	29.3	SELL, VIP, IL17A, IL1A, IL1B, IL6
14	myasthenia gravis	29.3	VIP, CHKB, CD28, CD79A, CD86, CD40LG
15	nasopharyngitis	29.2	KIT, KIR2DS5, KITLG, VDR, VCAM1, BMP6
16	bronchiectasis	29.0	MPO, CD79A, CD14, MMP8, MMP9, IL10
17	sudden infant death syndrome	28.1	S100A1, FOS, GSTT1, IL10, IL1B, IL1RN
18	leukemia	27.3	PIK3C2A, NCF2, KIT, KIR2DS5, KITLG, KIR3DL1
19	pemphigus	26.8	JUN, CD79A, CD40LG, CD40, CDH1, MMP9
20	pulmonary disease	26.7	NCF2, SFTPA1, SFTPB, SFTPC, SFTPD, SELE
21	anemia	26.4	KIT, KITLG, SELE, SELL, VDR, VCAM1
22	carcinoma	26.3	PIK3C2A, NCF2, KIT, KIR2DS5, KITLG, KIR3DL1
23	neuroendocrine carcinoma	26.3	KIT, SCGB1A1, MUC1, CD79A, CDH1, MMP7
24	blindness	25.2	PIK3C2A, SELE, VIP, VDR, CHKB, MPO
25	fibrosis	24.9	NCF2, KIT, KITLG, SFTPA1, SFTPB, SFTPC
26	allergic asthma	16.4	VCAM1, BMP6, SCGB1A1, MS4A2, CD209, CD28
27	hypersensitivity reaction type ii disease	15.7	KIR3DL1, SELL, VIP, VDR, VCAM1, BMP6
28	sarcoidosis	15.7	PIK3C2A, SFTPD, SELE, SELL, VDR, VCAM1
29	atopic dermatitis	15.6	KITLG, SELE, SELL, VIP, VCAM1, MS4A2
30	dengue hemorrhagic fever	15.6	VDR, CHKB, JAK1, JAK2, CD209, CD40LG
31	hemorrhagic fever	15.6	VDR, VCAM1, CHKB, JAK1, JAK2, CD209
32	commensal bacterial infectious disease	15.6	SFTPD, SELL, CHUK, CD86, CD14, CD80
33	viral infectious disease	15.4	KITLG, KIR3DL1, CD209, CD28, CD40LG, CD80
34	encephalomyelitis	15.3	KITLG, VIP, VCAM1, BMP6, MPO, CD86
35	ulcerative colitis	15.3	SELE, SELL, VIP, CHKB, MUC2, MPO
36	crohn's disease	15.2	CHUK, MUC2, MPO, CD80, FOXP3, IRF1
37	sepsis	15.2	SFTPD, SELE, SELL, MPO, CD14, ITGB2
38	leishmaniasis	15.2	PIK3C2A, NCF2, BMP6, JUN, JAK1, JAK2
39	familial mediterranean fever	15.2	KIR2DS5, KIR3DL1, SELL, CD14, IL10, IL12A
40	anterior uveitis	15.1	KIR2DS5, KIR3DL1, IL10, IL1RN, IL6, IL8
41	osteolysis	15.1	PIK3C2A, BMP6, JUN, MMP7, MMP9, IL10
42	spontaneous abortion	15.1	KIR2DS5, KIR3DL1, CD40LG, ITGB2, FOXP3, IL10
43	visceral leishmaniasis	15.1	BMP6, CD28, FOXP3, IL10, IL10RA, IL13
44	aspergillosis	15.0	NCF2, SFTPA1, SFTPD, CD209, CD79A, IL10
45	emphysema	15.0	SFTPB, SFTPC, SFTPD, BMP6, SCGB1A1, MPO
46	septic arthritis	15.0	MMP9, IL1B, CCL18, IFNG, TNF, TNFRSF1B
47	toxic shock syndrome	15.0	PIK3C2A, CD40LG, FCER2, IL10, IL1B, IL1RN
48	chronic obstructive pulmonary disease	14.9	SFTPB, SFTPD, SCGB1A1, MUC2, MUC5AC, MPO
49	mastitis	14.9	CD14, ITGB2, IL1B, IL1R1, IL1R2, IL1RN
50	pulmonary eosinophilia	14.9	SFTPD, IL13, IL3, IL4, IL5, IL8

Symptoms: cough, wheezing, shortness of breath, fever, nasal flaring in infants, bluish skin due to lack of oxygen.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to bronchiolitis:

²²

MGI Mouse Phenotypes related to bronchiolitis:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	12.5	KIT, RAD50, CHUK, JAK1, CD28, CD86
2	respiratory system phenotype	MP:0005388	11.0	SFTPC, SFTPD, SELL, RAD50, SCGB1A1, CD14
3	tumorigenesis	MP:0002006	10.5	KIT, KITLG, SFTPC, SELL, RAD50, SCGB1A1
4	adipose tissue phenotype	MP:0005375	10.3	PIK3C2A, CD14, FGF10, IL18, IL1R1, IL6
5	liver/biliary system phenotype	MP:0005370	10.3	KIT, RAD50, CHKA, IL10RB, IL12RB2, IL1R1
6	endocrine/exocrine gland phenotype	MP:0005379	10.2	SELL, RAD50, CD40LG, FGF10, IL2, IL22
7	renal/urinary system phenotype	MP:0005367	10.2	KIT, SCGB1A1, CHUK, FGF10, IL27RA, IL5RA
8	no phenotypic analysis	MP:0003012	10.1	SFTPC, VCAM1, MUC1, CD209, CD79A, CDH1
9	immune system phenotype	MP:0005387	10.0	KIT, SELL, VDR, RAD50, CHUK, MUC2
10	normal phenotype	MP:0002873	9.5	SELE, VIP, SCGB1A1, JAK2, CD28, CD79A
11	other phenotype	MP:0005395	9.5	JAK2, CD40LG, IL13, IL2, CCR2, CAV2
12	mortality/aging	MP:0010768	9.2	PIK3C2A, KITLG, SFTPB, SFTPC, SFTPD, SELE
13	reproductive system phenotype	MP:0005389	9.2	SFTPC, VIP, VDR, RAD50, CHUK, CDH1
14	skeleton phenotype	MP:0005390	9.0	KIT, KITLG, VDR, BMP6, CHUK, JUN
15	behavior/neurological phenotype	MP:0005386	8.9	KIT, SFTPB, SFTPC, SELE, VIP, RAD50
16	digestive/alimentary phenotype	MP:0005381	8.6	KIT, KITLG, VDR, MUC1, MUC2, MUC5AC
17	nervous system phenotype	MP:0003631	8.6	KIT, KITLG, RAD50, CHKB, CHUK, CD28
18	integument phenotype	MP:0010771	8.6	KIT, KITLG, CHUK, MUC1, ITGB2, FOS
19	cellular phenotype	MP:0005384	8.5	KIT, KITLG, SELE, SELL, VDR, VCAM1
20	homeostasis/metabolism phenotype	MP:0005376	8.4	PIK3C2A, KIT, KITLG, SFTPB, SFTPD, SELE
21	muscle phenotype	MP:0005369	8.1	KIT, CHKB, S100A1, MPO, CD86, MMP9
22	growth/size phenotype	MP:0005378	8.0	PIK3C2A, KIT, KITLG, SFTPC, SFTPD, SELE
23	vision/eye phenotype	MP:0005391	8.0	KIT, KITLG, SFTPC, SELE, UNC119, CHUK
24	cardiovascular system phenotype	MP:0005385	7.5	KIT, KITLG, SFTPC, SELE, SELL, VDR

Articles related to bronchiolitis:

(show top 50)    (show all 155)

id	Title	Authors	Year	Affiliating Genes
1	Endothelin-1 governs proliferation and migration of b ronchoalveolar lavage-derived lung mesenchymal stem cells in bronchiolitis obli terans syndrome. (21701423)	Salama M.... Aharinejad S.	2011	EDN1
2	IL10 family member genes IL19 and IL20 are associated with recurrent wheeze after respiratory syncytial virus bronchiolitis. (21814157)	Ermers M.J.... Bont L.J.	2011	IL19
3	The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis . (20437253)	Chen J.... Liu E.	2010	IL17A
4	Consensus conference on acute bronchiolitis (IV): Tr eatment of acute bronchiolitis. Review of scientific evidence (20347407)	GonzA!lez de Dios J.... Ochoa Sangrador C.	2010	APEX1
5	Increased net gelatinase but not serine protease acti vity in bronchiolitis obliterans syndrome. (20417130)	Riise G.C.... LindAcn A.	2010	MMP9
6	Serum KL-6 levels as a biomarker of lung injury in re spiratory syncytial virus bronchiolitis. (19856476)	Kawasaki Y.... Hosoya M.	2009	MUC1
7	Circulating and intrapulmonary C-reactive protein: a predictor of bronchiolitis obliterans syndrome and pulmonary allograft outcome. (19632576)	Vos R.... Verleden G.M.	2009	IL8
8	Plasma C-reactive protein levels correlate with markers of airway inflammation after lung transplantation: a role for systemic inflammation in bronchiolitis obliterans syndrome? (19328934)	Vos R.... Verleden G.M.	2009	CRP
9	Expression of CD40 and CD40 ligand in peripheral blood mononuclear cells in children with bronchiolitis. (19470255)	Zhu P.... Zou L.P.	2009	CD40LG, CD40, IGHE
10	Association of INF-gamma/A+874T gene polymorphisms with respiratory syncytial virus bronchiolitis (19149916)	Dong L.... Lin J.	2009	IFNG, IGHE
11	Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster. (19131452)	Forton J.T.... Hull J.	2009	IL3, IL4, RAD50
12	Association of tumor necrosis factor-alpha-308G/A an d interleukin-6-174G/C gene polymorphisms with the susceptibility of respirator y syncytial virus bronchiolitis (19849941)	Zhang Y.L.... Chen X.F.	2009	TNF, IL6
13	IL-10 gene polymorphism at -1082 A/G is associated with severe rhinovirus bronchiolitis in infants. (18286551)	Helminen M.... Hurme M.	2008	TLR4, IL18, IFNG
14	Relation between serum IL-4, IL-13 and IFN-gamma levels and recurrence of wheezing episodes in infants with acute bronchiolitis. (18312531)	Uzuner N.... Tezcan D.	2008	IL13
15	Th1 and Th2 cytokine levels in nasopharyngeal aspirat es from children with human bocavirus bronchiolitis. (18650126)	Chung J.Y.... Hwang E.S.	2008	IL5
16	Attenuation of airway obliteration by ciprofloxacin in experimental posttransplant bronchiolitis obliterans. (18337667)	Remund K.... Boehler A.	2008	TNF, IFNG, BMP6
17	Neutrophil but not eosinophil inflammation is related to the severity of a first acute epidemic bronchiolitis in young infants. (18093085)	Marguet C.... MacAc B.	2008	RNASE3
18	Serum thymus and activation regulated chemokine levels post-lung transplantation as a predictor for the bronchiolitis obliterans syndrome. (18785972)	Paantjens A.W.... Otten H.G.	2008	CCL17
19	Inducible costimulator blockade prolongs airway lumin al patency in a mouse model of obliterative bronchiolitis. (19034015)	Kleinjan A.... Lambrecht B.N.	2008	ICOS
20	Eosinophil cationic protein and chemokines in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis. (17297249)	Kim H.H.... Lee J.S.	2007	CCL11, RNASE3
21	Bronchoalveolar cellularity and interleukin-8 levels in measles bronchiolitis obliterans. (17494793)	Koh Y.Y.... Kim C.K.	2007	IL8
22	CD14 -550 C/T, which is related to the serum level of soluble CD14, is associated with the development of respiratory syncytial virus bronchiolitis in the Japanese population. (17471431)	Inoue Y.... Kohno Y.	2007	CD14
23	Association between interleukin-8 gene-251 locus polymorphism and respiratory syncytial virus bronchiolitis and post-bronchiolitis wheezing in infants (18282421)	Tian M.... Chen R.H.	2007	IL8
24	Recombinant human deoxyribonuclease in infants with respiratory syncytial virus bronchiolitis. (17356094)	Boogaard R.... Merkus P.J.	2007	APEX1
25	Cytokines in the nasal washes of children with respiratory syncytial virus bronchiolitis. (16569362)	Midulla F.... Moretti C.	2006	IL10, IFNA1
26	Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis. (15765744)	Chung H.L.... Kim S.G.	2005	MPO, IL10, IL11
27	Matrix metalloproteinase-9 in bronchiolitis obliteran s syndrome after lung transplantation. (15738294)	HA1bner R.H.... Bewig B.	2005	MMP9
28	BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation. (15998790)	Medoff B.D.... Luster A.D.	2005	LTB4R
29	Broncho-alveolar lavage matrix metalloproteases as a sensitive measure of bronchiolitis obliterans. (15888067)	Taghavi S.... Aharinejad S.	2005	MMP8, MMP9, TIMP1
30	A comparison of epidemiologic and immunologic features of bronchiolitis caused by influenza virus and respiratory syncytial virus. (15602730)	Garofalo R.P.... Welliver R.C.	2005	CCL2, CCL5, CCL3
31	Elevated levels of soluble adhesion molecules in sera of patients with acute bronchiolitis. (15221034)	Lai C.C.... Tang R.B.	2004	ICAM1
32	Bronchoalveolar lavage cytokine profile in a cohort of lung transplant recipients: a predictive role of interleukin-12 with respect to onset of bronchiolitis obliterans syndrome. (15454171)	Meloni F.... ViganA^ M.	2004	IL8, BMP6
33	The role of leukotrienes and eosinophil cationic protein in acute respiratory syncytial virus bronchiolitis. (15366660)	Dimova-Yaneva D.N.... Helms P.J.	2003	RNASE3
34	Interleukin-17 stimulates release of interleukin-8 by human airway smooth muscle cells in vitro: a potential role for interleukin-17 and airway smooth muscle cells in bronchiolitis obliterans syndrome. (14585390)	Vanaudenaerde B.M.... Verleden G.M.	2003	IL8, IL17A
35	Variants of the chemokine receptor CCR5 are associated with severe bronchiolitis caused by respiratory syncytial virus. (12964123)	Hull J.... Kwiatkowski D.	2003	CCR5
36	Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation. (12451269)	Lu K.C.... Mohanakumar T.	2002	TGFB1, TNF, IL6
37	Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. (12097412)	Belperio J.A.... Strieter R.M.	2002	CXCR3
38	Growth factor upregulation during obliterative bronchiolitis in the mouse model. (12153981)	Aris R.M.... Neuringer I.P.	2002	EGF, TNFRSF1A, BMP6
39	Mechanisms of leukotriene D4-induced constriction in human small bronchioles. (11350860)	Snetkov V.A.... Ward J.P.	2001	DYT10
40	Increased expression of iNOS and c-fos via regulation of protein tyrosine phosphorylation and MEK1/ERK2 proteins in terminal bronchiole lesions in the lungs of rats exposed to cigarette smoke. (11357518)	Chang W.C.... Wang C.J.	2001	MAP2K1, MAPK1, FOS
41	Morphometric analysis of CC10-hASH1 transgenic mouse lung: a model for bronchiolization of alveoli and neuroendocrine carcinoma. (11195458)	Linnoila R.I.... DeMayo F.J.	2000	SCGB1A1, TAG
42	Eosinophilic granulocytes and interleukin-6 level in bronchoalveolar lavage fluid are associated with the development of obliterative bronchiolitis after lung transplantation. (11112142)	Scholma J.... Postma D.S.	2000	IL6, IL8, CCL2
43	Effect of ICAM-1 blockade on lung inflammation and physiology during acute viral bronchiolitis in rats. (10832744)	Sorkness R.L.... Lemanske R.F.	2000	ICAM1
44	IL-8 and neutrophil elastase levels in the respiratory tract of infants with RSV bronchiolitis. (10489841)	Abu-Harb M.... Everard M.L.	1999	IL8
45	Reduced interferon-gamma production in infants with bronchiolitis and asthma. (10228104)	Renzi P.M.... Spier S.	1999	IFNG
46	Differential patterns of circulating adhesion molecules in children with bronchial asthma and acute bronchiolitis. (9677602)	Oymar K.... Bjerknes R.	1998	ICAM1, SELL, SELE
47	Differential effects of cyclosporin A and tacrolimus on the production of TGF-beta: implications for the development of obliterative bronchiolitis after lung transplantation. (9665007)	Zhang J.G.... Kirby J.A.	1998	BMP6
48	Bronchiolization of the alveoli in lung cancer: pathology, patterns of differentiation and oncogene expression. (9466646)	Jensen-Taubman S.M.... Linnoila R.I.	1998	KRT14
49	Immunohistochemical localization of nitric oxide synthase and the oxidant peroxynitrite in lung transplant recipients with obliterative bronchiolitis. (9256186)	McDermott C.D.... Giaid A.	1997	NOS2
50	Peripheral blood eosinophil counts and eosinophil cationic protein content of respiratory secretions in bronchiolitis: relationship to severity of disease. (8087190)	Garofalo R.... Welliver R.C.	1994	RNASE3

Genes related to bronchiolitis according to GeneCards:

(show top 50)    (show all 290)

id	Symbol	Description	Score	GeneCards Section Context
1	IL8	interleukin 8	11.1	Publications, Summaries
2	RASSF6	Ras association (RalGDS/AF-6) domain family member 6	11.0	Publications, Summaries
3	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
4	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
5	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
6	IL17A	interleukin 17A	11.0	Publications
7	IFNA2	interferon, alpha 2	11.0	Publications
8	TLR4	toll-like receptor 4	11.0	Publications
9	IL13	interleukin 13	11.0	Publications
10	TLR10	toll-like receptor 10	11.0	Publications
11	TLR8	toll-like receptor 8	11.0	Publications
12	TLR1	toll-like receptor 1	11.0	Publications
13	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
14	SFTPD	surfactant protein D	11.0	Publications
15	TLR9	toll-like receptor 9	11.0	Publications
16	TLR3	toll-like receptor 3	11.0	Publications
17	TLR5	toll-like receptor 5	11.0	Publications
18	TLR7	toll-like receptor 7	11.0	Publications
19	TLR6	toll-like receptor 6	11.0	Publications
20	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	11.0	Publications
21	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
22	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
23	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	11.0	Publications
24	IL11	interleukin 11	11.0	Publications
25	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
26	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
27	CHKA	choline kinase alpha	11.0	Publications
28	IL4R	interleukin 4 receptor	11.0	Publications
29	SELL	selectin L	11.0	Publications
30	MAPKAP1	mitogen-activated protein kinase associated protein 1	11.0	Publications
31	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
32	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
33	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
34	PDGFB	platelet-derived growth factor beta polypeptide	11.0	Publications
35	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
36	MUC1	mucin 1, cell surface associated	11.0	Publications
37	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
38	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
39	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
40	TLR2	toll-like receptor 2	11.0	Publications
41	BMP6	bone morphogenetic protein 6	11.0	Publications
42	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
43	IL10	interleukin 10	11.0	Publications
44	CRP	C-reactive protein, pentraxin-related	11.0	Publications
45	TGFB1	transforming growth factor, beta 1	11.0	Publications
46	TNF	tumor necrosis factor	11.0	Publications
47	IFNG	interferon, gamma	11.0	Publications
48	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
49	ALB	albumin	11.0	Publications
50	IL1B	interleukin 1, beta	11.0	Publications

Pathways related to bronchiolitis according to GeneDecks:

(show top 50)    (show all 246)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	13.0	CD80, IL11, IL12A, IL15, IL16, IL19
2	PGC1Alpha Pathway36	12.8	BMP6, CD80, IL10RA, IL10RB, IL11, IL12A
3	MIF Regulation of Innate Immune Cells36	12.8	BMP6, JUN, CD14, CD80, FOS, IL10
4	PAK Pathway36	12.7	KIT, KITLG, BMP6, CD80, FGF10, IL10
5	p38 Signaling36	12.7	KIT, KITLG, BMP6, CD28, CD80, IRAK4
6	PEDF Induced Signaling36	12.7	BMP6, CHUK, CD80, FOS, IL10, IL11
7	NFAT Signaling and Lymphocyte Interactions36	12.5	BMP6, CD80, FCER1A, FCER2, IL11, IL12A
8	Glucocorticoid Receptor Signaling36	12.3	BMP6, JUN, CD80, FOS, IL10, IL10RA
9	Transendothelial Migration of Leukocytes36	12.3	NCF2, VCAM1, ITGB2, MMP7, MMP8, MMP9
10	Chemokine Signaling36	12.1	JUN, JAK2, FOS, IL8, MAPK1, CCL8
11	Measles20	11.8	CHUK, JAK1, JAK2, CD209, CD28, IRAK4
12	Immune response_TLR signaling pathways41	11.8	SFTPA1, CHUK, JUN, CD14, IRAK4, IL11
13	TRAF Pathway36	11.8	CHUK, JUN, FOS, IRAK4, IL12A, IL12B
14	SOCS Pathway36	11.7	BMP6, JAK1, JAK2, CD80, FGF10, IL10
15	Toll-Like Receptors Pathway36	11.7	CHUK, JUN, CD14, IRAK4, IRF3, IKBKB
16	IL-10 Pathway36	11.4	JAK1, CD14, IL10, IL10RA, IL10RB, IL1A
17	Bacterial infections in CF airways41	11.4	SFTPA1, SFTPD, CHUK, MUC1, IRAK4, IRF1
18	Cytosolic DNA-sensing pathway20	11.4	CHUK, IRF3, IL18, IL1B, IL6, CCL4
19	IL-9 Pathway36	11.3	JAK1, GZMA, IL9, IL9R, TNF, TNFRSF1A
20	Amoebiasis20	11.2	MUC2, CD14, ITGB2, ARG1, IL12A, IL12B
21	Molecular Mechanisms of Cancer36	11.2	KITLG, BMP6, JUN, JAK1, CD80, CDH1
22	Immune response_Bacterial infections in normal airways41	11.2	CHUK, JAK1, CD14, IRAK4, IRF1, IL1B
23	Influenza A20	11.1	JUN, JAK1, JAK2, IRAK4, IRF3, IRF9
24	Cytokine production by Th17 cells in CF41	11.0	CHUK, JAK1, JAK2, CD14, IL12B, IL12RB1
25	RIG-I-like receptor signaling pathway20	11.0	CHUK, IRF3, IL12A, IL12B, MAP3K1, IFIH1
26	THC Differentiation Pathway36	11.0	CD28, CD86, IL10, IL10RA, IL10RB, IL12A
27	Chagas disease (American trypanosomiasis)20	11.0	CHUK, JUN, FOS, IRAK4, IL10, IL12A
28	Immune response IL-12-induced IFN-gamma production10	10.9	CHUK, JUN, JAK2, IL12A, IL12B, IL12RB1
29	Rho Family GTPases36	10.8	NCF2, KIT, KITLG, BMP6, JUN, CD80
30	TREM1 Pathway36	10.8	CHUK, JUN, FOS, IRAK4, IL1A, IL1B
31	Immune response_MIF in innate immunity response41	10.8	CHUK, JUN, CD14, IRAK4, IL1B, IL6
32	NF-KappaB Family Pathway36	10.8	KITLG, BMP6, CHUK, IRAK4, FGF10, IL1A
33	Immune System38	10.8	KIR2DS5, KIR3DL1, VCAM1, JAK1, CD79A, CD40
34	Toxoplasmosis20	10.7	CHUK, JAK1, JAK2, CD40LG, CD40, IRAK4
35	TGF-Beta Pathway36	10.7	KITLG, BMP6, JUN, CD80, CDH1, FOS
36	Autoimmune thyroid disease20	10.6	CD28, CD86, CD40LG, CD80, CD40, GZMB
37	Immune response_IL-1 signaling pathway41	10.6	CHUK, JUN, FOS, IRAK4, IRF1, IL1A
38	Leishmaniasis20	10.4	NCF2, JUN, JAK1, JAK2, ITGB2, FOS
39	Immune response IL-9 signaling pathway10	10.4	CHUK, JAK1, IL22, IL2RG, IL9, IL9R
40	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.3	GZMA, GZMB, IL15, IL15RA, IL2, IL2RA
41	Hepatitis C20	10.3	CHUK, JAK1, IRF1, IRF3, IRF9, IL8
42	Colorectal Cancer Metastasis36	10.1	JAK1, CDH1, MMP7, MMP9, IL6, IL6R
43	Immune response MIF-mediated glucocorticoid regulation10	10.0	VCAM1, CHUK, JUN, FOS, IL2, IL6
44	Immune response_MIF-mediated glucocorticoid regulation41	10.0	VCAM1, CHUK, JUN, FOS, IL2, IL6
45	Immune response IL-22 signaling pathway10	9.9	JUN, JAK1, JAK2, CD28, CD86, FOS
46	Mucin expression in CF via TLRs, EGFR signaling pathways41	9.9	CHUK, MUC2, MUC5AC, MUC5B, JUN, FOS
47	Hematopoietic cell lineage20	9.9	KIT, KITLG, CD14, FCER2, IL11, IL1A
48	Immune response_IL-22 signaling pathway41	9.9	JUN, JAK1, JAK2, CD28, CD86, FOS
49	Apoptotic Pathways in Synovial Fibroblasts36	9.4	KIT, KITLG, BMP6, FGF10, IL2, IL2RA
50	Pancreatic Adenocarcinoma36	8.3	KIT, KITLG, BMP6, JAK1, JAK2, MMP7

Compounds related to bronchiolitis according to GeneDecks:

(show top 50)    (show all 417)

id	Compound	Score	Top Affiliating Genes
1	peptidoglycan32	12.2	CHUK, CD14, IL10, IL12B, IL15, IL1B
2	allergens32	11.6	SFTPD, MS4A2, CD209, CD79A, CD86, CD14
3	endotoxin32	11.3	SFTPD, SELL, SCGB1A1, CHKB, JAK2, CD86
4	pentoxifylline32 9 9	13.0	SELL, VCAM1, BMP6, MPO, CD14, ITGB2
5	sodium nitroprusside32	11.0	PIK3C2A, VIP, BMP6, CD40, IL12B, IL13
6	sp 60012532 42	11.9	VCAM1, CD40, IL13, IL17A, MAP3K1, IKBKB
7	rolipram32 42	11.9	SELE, SELL, ITGB2, IL10, IL13, IL4
8	vitamin a32 9 18 9	13.9	SFTPB, VDR, SCGB1A1, CHKA, IGHE, IFNA2
9	amphotericin b32	10.8	IL13, IL1R1, IL1RN, IL4, IL5, CCL4
10	ethanol32 34 9 18 9	14.7	KITLG, SFTPC, CHKA, MUC1, MUC5AC, CD14
11	methacholine32 9 9	12.7	VIP, MPO, CD79A, CD14, IL13, IL17A
12	fluticasone propionate32 42 9 9	13.7	SELE, VCAM1, MPO, MMP9, IL13, IL16
13	fluvastatin32 34 9 9	13.7	PIK3C2A, VCAM1, CHKB, CD40, MMP9, IL1A
14	latex32	10.7	KITLG, SCGB1A1, CHKB, CD14, CDH1, IL18
15	bleomycin32 9 9	12.6	SFTPB, SFTPC, IL13, IL2RA, IL4, IL5
16	atp32	10.6	PIK3C2A, NCF2, KIT, KIR3DL1, SFTPB, RAD50
17	salbutamol32 34 9 18 9	14.6	KITLG, VIP, VCAM1, CHKB, CD79A, ITGB2
18	2,5-oligoadenylate32	10.5	IRF1, IRF9, IL10, IL2, IL2RA, IL2RB
19	polyinosinic-polycytidylic acid32	10.5	SELE, VCAM1, CD40, IRF1, IRF3, IL10
20	cholesterol32 9 18 9	13.4	PIK3C2A, KITLG, SFTPB, SFTPC, SFTPD, SELE
21	neopterin32	10.3	CHKB, CD79A, CD14, CD40LG, CD40, GZMB
22	isoproterenol32 9 9	12.3	SELL, IL13, IL1A, IL3, IL5, MAPK1
23	dmso32	10.1	KITLG, BMP6, MUC5AC, MMP7, MAP2K1, ALOX5
24	arachidonic acid32 9 18 9	13.1	NCF2, KITLG, CLC, SCGB1A1, JAK2, CDH1
25	epinephrine32 9 18 9	13.1	PIK3C2A, KITLG, SELE, SELL, VIP, BMP6
26	etoposide32 42 9 9	13.0	SELE, JUN, CDH1, GZMB, IRF1, IL3
27	glutamine32	9.9	KIT, SFTPD, VIP, VDR, BMP6, CHKB
28	troglitazone32 42 9 9	12.9	SELE, VDR, VCAM1, BMP6, JUN, CDH1
29	h2o232	9.8	NCF2, KITLG, SELL, VIP, MPO, JAK1
30	ribavirin32 34 9 9	12.7	CD40LG, MMP9, IL10, IL18, IL2, IL3
31	ascorbic acid32 18	10.6	SFTPB, VDR, CHKA, CHKB, CHUK, P4HA2
32	curcumin32	9.6	VCAM1, CHUK, JUN, JAK1, JAK2, CDH1
33	doxycycline32 9 9	11.5	SFTPB, SFTPC, SCGB1A1, CD79A, CD40LG, MMP8
34	alanine32	9.5	PIK3C2A, KITLG, SELE, SELL, VIP, VDR
35	nifedipine32 9 9	11.5	SELE, VIP, BMP6, CD40, MMP9, IL1A
36	polysaccharide32	9.5	KITLG, SFTPD, SELE, SELL, VCAM1, BMP6
37	pdtc32	9.4	SFTPB, SELE, VCAM1, CHUK, JUN, CD40
38	rapamycin32 42	10.2	KIT, KITLG, SELL, JAK2, CD86, CD80
39	cysteine32	9.2	SFTPB, SFTPC, SFTPD, VDR, CHKB, CHUK
40	imatinib32 34 9 9	12.0	KIT, KITLG, SELL, VIP, BMP6, JAK2
41	vitamin d32	9.0	VDR, BMP6, CHKA, CHKB, JUN, CD79A
42	creatinine32	8.9	KITLG, SELE, SELL, VDR, BMP6, SCGB1A1
43	mycophenolate mofetil32 9 9	10.8	SELE, CD79A, CD40LG, CD40, IL10, IL11
44	glutamate32	8.8	VIP, VDR, BMP6, CHKA, CHUK, JAK2
45	methylcellulose32	8.8	KIT, KITLG, CD14, CDH1, IL11, IL15
46	thymidine32 18	9.8	KIT, KITLG, SFTPB, SFTPD, VIP, VDR
47	12-o-tetradecanoylphorbol 13-acetate32	8.8	SFTPB, BMP6, CHUK, MUC2, JAK1, JAK2
48	cytochalasin d32 42	8.8	KITLG, SELE, SELL, VCAM1, JAK2, CDH1
49	pd 98,05932	7.7	KIT, KITLG, VCAM1, BMP6, CHUK, MUC2
50	testosterone32 9 18 9	9.3	PIK3C2A, KIT, KITLG, SELE, VIP, VDR

Cellular components related to bronchiolitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	12.1	CCL5, CCL15, CCL4, CCL8, MBL2, IL9R
2	extracellular region	GO:005576	11.4	PRF1, DEFB4A, TAC1, TGFB2, TGFB1, TIMP1
3	integral to plasma membrane	GO:005887	11.3	SELL, KIR3DL1, KIR2DS5, MUC1, ADRB2, SLC22A4
4	external side of plasma membrane	GO:009897	10.4	CXCR3, CD40LG, CD86, CD79A, CD28, MS4A2
5	cell surface	GO:009986	10.0	PDGFA, PDGFB, ELANE, HBEGF, TLR2, TLR3
6	platelet alpha granule lumen	GO:031093	9.6	TGFB2, TGFB1, TIMP1, EGF, PDGFB, PDGFA
7	membrane raft	GO:045121	9.3	TNFRSF1B, TNFRSF1A, TNF, CAV1, CAV2, IKBKB
8	plasma membrane	GO:005886	8.5	NOD2, NGFR, NFKBIA, LTB4R, EGF, TLR1
9	cytosol	GO:005829	8.4	NR3C1, NOD2, NOS1, NOS2, NGFR, OAZ1

Biological processes related to bronchiolitis according to GeneDecks:

(show top 50)    (show all 122)

id	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:006955	13.7	KIR2DS5, KIR3DL1, BMP6, CHIA, CHUK, CD86
2	inflammatory response	GO:006954	13.0	KIT, SELE, BMP6, CHUK, MS4A2, CD14
3	cell-cell signaling	GO:007267	12.4	CD86, CD80, ITGB2, IL10, IL11, IL13
4	response to virus	GO:009615	12.2	CHUK, FOXP3, IRF5, IRF9, IL12A, IL23A
5	type I interferon-mediated signaling pathway	GO:060337	11.7	JAK1, IRF1, IRF3, IRF5, IRF9, IFI27
6	chemotaxis	GO:006935	11.7	IL4, MAPK1, MAP2K1, CCL8, CCL4, CCL15
7	cytokine-mediated signaling pathway	GO:019221	11.7	KIT, VCAM1, JAK1, JAK2, IRAK4, IRF1
8	defense response to bacterium	GO:042742	11.6	IL10, IFNG, GNLY, TNFRSF1A, PPBP, NOD2
9	positive regulation of NF-kappaB import into nucleus	GO:042346	11.5	IL12B, IL1B, IL23A, CCL19, TNF, TLR2
10	positive regulation of NF-kappaB transcription factor activity	GO:051092	11.5	CHUK, CD40, IL1B, IL6, IL6R, IKBKB
11	defense response to virus	GO:051607	11.4	CD86, CD40, IRF1, IRF3, IL12B, IL6
12	regulation of type I interferon-mediated signaling pathway	GO:060338	11.4	JAK1, IFNA13, IFNA14, IFNA2, IFNA5, IFNA6
13	cellular response to mechanical stimulus	GO:071260	11.4	SFTPB, SFTPC, CD40, IRF1, IL13, IL18
14	positive regulation of tumor necrosis factor production	GO:032760	11.4	JAK2, CD14, IL12B, IL18, IL23A, CCL3
15	positive regulation of interferon-gamma production	GO:032729	11.4	CD40LG, IL12A, IL12B, IL12RB1, IL12RB2, IL18
16	positive regulation of interleukin-6 production	GO:032755	11.3	IL1A, IL1B, IL6, IL6R, TNF, NOD2
17	innate immune response	GO:045087	11.3	NCF2, SFTPD, CHUK, JUN, CD209, CD14
18	positive regulation of inflammatory response	GO:050729	11.3	JAK2, IL12B, IL15, IL18, IL2, IL21
19	positive regulation of interleukin-12 production	GO:032735	11.3	CD40LG, CD40, IL12B, IL23A, IL23R, CCL19
20	positive regulation of T cell proliferation	GO:042102	11.2	VCAM1, CD28, IL12A, IL12B, IL15, IL1B
21	cellular calcium ion homeostasis	GO:006874	11.2	VDR, CD40, CCL8, CCL15, CCL7, CCR2
22	positive regulation of chemokine production	GO:032722	11.2	IL18, IL6, IL6R, TNF, TLR2, TLR3
23	lipopolysaccharide-mediated signaling pathway	GO:031663	11.2	IRF3, IL18, IL1B, CCL2, CCL3, CCL5
24	positive regulation of smooth muscle cell proliferation	GO:048661	11.2	JUN, IRAK4, IL13, IL6, IL6R, CCL5
25	cell surface receptor signaling pathway	GO:007166	11.2	CD28, CD14, IRF9, IL12RB2, IL13RA1, IL17RA
26	positive regulation of transcription from RNA polymerase II promoter	GO:045944	11.1	VDR, BMP6, JUN, CD40, FOXP3, IRAK4
27	neutrophil chemotaxis	GO:030593	11.0	ITGB2, IL1B, IL8, CCL2, CCL3, IFNG
28	response to hypoxia	GO:001666	11.0	SFTPB, VCAM1, MMP9, IL18, IL1A, IL1B
29	positive regulation of interleukin-17 production	GO:032740	10.9	IL12B, IL15, IL18, IL2, IL21, IL23A
30	cellular response to lipopolysaccharide	GO:071222	10.9	CD14, ARG1, IL10, IL12B, IL8, CCL2
31	response to drug	GO:042493	10.8	NCF2, JUN, CDH1, MMP7, MMP9, ARG1
32	JAK-STAT cascade	GO:007259	10.8	JAK2, CCR2, CCL2, IFNAR1, IFNAR2, STAT3
33	eosinophil chemotaxis	GO:048245	10.8	CCL7, CCL11, CCR3, CCL3, CCL24, CCL13
34	response to glucocorticoid stimulus	GO:051384	10.6	SFTPB, SFTPC, IL10, IL1B, IL1RN, IL6
35	signal transduction	GO:007165	10.6	KIT, KITLG, VDR, RASSF6, SCGB1A1, CHKA
36	positive regulation of cell migration	GO:030335	10.5	JAK2, MAP2K1, CCL7, CCL26, CCL11, CCL3
37	monocyte chemotaxis	GO:002548	10.4	IL6, IL6R, CCL7, CCL2, CCL23, CCL3
38	aging	GO:007568	10.3	NCF2, VDR, VCAM1, JUN, IL15, IL1B
39	MyD88-dependent toll-like receptor signaling pathway	GO:002755	10.2	CHUK, JUN, FOS, IRAK4, MAPK1, MAP3K1
40	Toll signaling pathway	GO:008063	10.1	CHUK, JUN, CD14, FOS, IRAK4, IRF3
41	toll-like receptor 4 signaling pathway	GO:034142	10.1	CHUK, JUN, CD14, FOS, IRAK4, IRF3
42	toll-like receptor signaling pathway	GO:002224	10.1	CHUK, JUN, CD86, FOS, IRAK4, MAPK1
43	response to lipopolysaccharide	GO:032496	10.0	NCF2, SFTPB, SFTPC, SELE, JUN, JAK2
44	anti-apoptosis	GO:006916	10.0	MUC1, MPO, CD40LG, IL10, IL1A, IL1B
45	toll-like receptor 1 signaling pathway	GO:034130	9.9	CHUK, JUN, FOS, IRAK4, MAPK1, MAP3K1
46	TRIF-dependent toll-like receptor signaling pathway	GO:035666	9.9	CHUK, JUN, CD14, FOS, IRF3, MAPK1
47	toll-like receptor 2 signaling pathway	GO:034134	9.9	CHUK, JUN, FOS, IRAK4, MAPK1, MAP3K1
48	toll-like receptor 3 signaling pathway	GO:034138	9.8	CHUK, JUN, CD14, FOS, IRF3, MAPK1
49	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.8	KIT, JAK2, IL12B, IL2, IL23A, IL23R
50	positive regulation of cell proliferation	GO:008284	9.2	KIT, VIP, JAK2, CD86, IL11, IL12RB2

Molecular functions related to bronchiolitis according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	12.6	CCL15, CCL4, CCL8, IL8, C5, CXCL9
2	cytokine activity	GO:005125	11.9	IFNA14, IFNA13, CCL4, IL9, IL7, IL6
3	cytokine receptor activity	GO:004896	10.9	CSF3R, IL15RA, IL13RA2, IL13RA1, IL12RB2, IL12RB1
4	interleukin-1 receptor binding	GO:005149	10.9	TLR9, TLR5, IL1RN, IL1B, IL1A, IRAK4
5	cytokine receptor binding	GO:005126	10.9	IFNA8, IFNA6, IFNA5, IFNA14, IL21, IL15
6	signal transducer activity	GO:004871	10.8	NGFR, STAT3, STAT5A, STAT6, STAT1, STAT4
7	receptor activity	GO:004872	10.8	TLR2, TLR3, TLR4, TLR6, TLR8, CSF3R
8	heparin binding	GO:008201	10.7	COL5A1, PF4, LTF, ELANE, HBEGF, CXCL13
9	interleukin-12 receptor binding	GO:005143	10.6	IL23R, IL12RB1, IL12B, IL12A, JAK2
10	receptor binding	GO:005102	10.6	CAV1, NOS2, LTA, TGFB2, CX3CL1, CXCL1
11	CCR1 chemokine receptor binding	GO:031726	10.5	CCL4, CCL7, CCL23, CCL3, CCL5
12	transmembrane signaling receptor activity	GO:004888	10.4	TLR6, TLR4, TLR3, TLR2, TLR10, TLR1
13	protein homodimerization activity	GO:042803	10.3	NOS2, CRP, NR3C1, SRF, PTGS2, PDGFA
14	growth factor activity	GO:008083	9.7	CSF3, IL3, IL2, IL1B, IL12B, IL12A
15	protein binding	GO:005515	6.8	GATA3, EPO, ADRB2, C3, PECAM1, SLC22A5