MCID: BRN002
MIFTS: 52

Bronchiolitis

Categories: Respiratory diseases

Aliases & Classifications for Bronchiolitis

MalaCards integrated aliases for Bronchiolitis:

Name: Bronchiolitis 12 52 3 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2942
MeSH 42 D001988
NCIt 47 C39658
SNOMED-CT 64 4120002
UMLS 69 C0006271

Summaries for Bronchiolitis

CDC : 3 Respiratory syncytial (sin-SISH-uhl) virus, or RSV, is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover in a week or two, but RSV can be serious, especially for infants and older adults. In fact, RSV is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia (infection of the lungs) in children younger than 1 year of age in the United States. It is also a significant cause of respiratory illness in older adults.

MalaCards based summary : Bronchiolitis is related to ulcerative colitis and primary biliary cirrhosis. An important gene associated with Bronchiolitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bromhexine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.

Wikipedia : 72 Bronchiolitis is inflammation of the bronchioles, the smallest air passages of the lungs. It usually... more...

Related Diseases for Bronchiolitis

Diseases related to Bronchiolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 453)
id Related Disease Score Top Affiliating Genes
1 ulcerative colitis 30.7 IL10 IL6 TNF
2 primary biliary cirrhosis 30.1 IL10 IL6 TNF
3 mycobacterium kansasii 30.1 CXCL8 TLR1 TNF
4 pulmonary tuberculosis 30.0 CCL5 CXCL8 IFNG TNF
5 hepatitis b 30.0 CXCL8 IFNG IL10 TNF
6 nonspecific interstitial pneumonia 29.4 CCL3 CXCL8 IL10 IL5
7 systemic lupus erythematosus 29.2 CCL5 IFNG IL10 IL4 IL6 TLR9
8 acute interstitial pneumonia 29.2 IFNG IL10 IL4 IL6 TLR9 TNF
9 lymphoma 28.7 IFNG IL10 IL13 IL4 IL5 IL6
10 rheumatoid arthritis 28.5 CCL3 CCL5 CXCL8 IFNG IL10 IL4
11 melioidosis 28.3 IFNG IL10 IL6 TLR1 TLR10 TLR4
12 malaria 25.7 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
13 asthma 25.3 CCL11 CCL3 CCL5 CXCL8 IFNG IGHE
14 bronchiolitis obliterans 12.4
15 cryptogenic organizing pneumonia 11.9
16 bronchiolitis obliterans with obstructive pulmonary disease 11.8
17 respiratory bronchiolitis-interstitial lung disease syndrome 11.8
18 panbronchiolitis, diffuse 11.1
19 bronchitis 11.1
20 bronchopneumonia 11.1
21 bronchiectasis 11.0
22 parainfluenza virus type 3 11.0
23 swyer-james syndrome 11.0
24 bronchial disease 10.9
25 pure autonomic failure 10.9 IL10 TNF
26 myoclonic astatic epilepsy 10.8 IFNG IL4
27 amyotrophic lateral sclerosis type 10 10.8 CXCL8 IFNG TNF
28 interstitial pneumonitis, desquamative, familial 10.8
29 distal monosomy 7q36 10.8 CXCL8 IFNG IL10
30 congenital insensitivity to pain with hyperhidrosis 10.8 CXCL8 IL10 TLR4
31 eye accommodation disease 10.8 IFNG IL10 IL4
32 steatorrhea 10.8 CXCL8 IFNG TNF
33 acute ackee fruit intoxication 10.7 IL10 IL4 TNF
34 drug rash with eosinophilia and systemic symptoms 10.7 CXCL8 IL10 IL6
35 thelaziasis 10.7 IFNG IL10 IL4
36 spirillary rat-bite fever 10.7 CXCL8 IL6 TNF
37 lagophthalmos 10.7 IL10 IL4 TNF
38 surfactant metabolism dysfunction, pulmonary, 5 10.7
39 in situ pulmonary adenocarcinoma 10.7
40 extrinsic allergic alveolitis 10.7
41 infancy electroclinical syndrome 10.7 CXCL8 IL10 IL6
42 mycobacterium gordonae 10.7 CCL5 CXCL8 IL10
43 lymph node palisaded myofibroblastoma 10.7 CCL11 CXCL8 IL10
44 centronuclear myopathy 5 10.7 IFNG IL10 IL4
45 pneumonia 10.7
46 liver leiomyoma 10.7 IL10 IL4 TNF
47 hypospadias 10.7 IFNG IL10 TNF
48 smarca4-deficient sarcoma of thorax 10.7 CCL5 IL6 TNF
49 oculomotor nerve paralysis 10.7 CXCL8 IL6
50 louping ill 10.7 CXCL8 IFNG TNF

Graphical network of the top 20 diseases related to Bronchiolitis:



Diseases related to Bronchiolitis

Symptoms & Phenotypes for Bronchiolitis

MGI Mouse Phenotypes related to Bronchiolitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 IL13 IL4 IL4R IL5 IL6 MUC5B
2 digestive/alimentary MP:0005381 10.02 IL5 IL6 TLR4 TLR9 TNF IFNG
3 immune system MP:0005387 10 CCL11 CCL5 IFNG IL10 IL13 IL4
4 liver/biliary system MP:0005370 9.56 TNF IFNG IL10 IL4 IL4R IL5
5 respiratory system MP:0005388 9.36 CCL11 IFNG IL10 IL13 IL4 IL4R

Drugs & Therapeutics for Bronchiolitis

Drugs for Bronchiolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 214)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bromhexine Approved Phase 4 3572-43-8
2
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
3 Racepinephrine Approved Phase 4,Phase 3,Phase 2
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
8
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
9
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
10
Mechlorethamine Approved Phase 4,Phase 3,Phase 2 51-75-2 4033
11
Azithromycin Approved Phase 4,Phase 2,Phase 3,Phase 1 83905-01-5 55185 53477736 447043
12
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
13
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
14
Azathioprine Approved Phase 4 446-86-6 2265
15
Everolimus Approved Phase 4,Phase 3 159351-69-6 6442177
16
Prednisone Approved, Vet_approved Phase 4,Phase 1,Phase 2 53-03-2 5865
17
Sirolimus Approved, Investigational Phase 4,Phase 3 53123-88-9 5284616 6436030 46835353
18
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 104987-11-3 445643 439492
19
Macitentan Approved Phase 4 441798-33-0
20
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 67-97-0 6221 10883523 5280795
21
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
22
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
23 Epinephryl borate Phase 4,Phase 3,Phase 2
24 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
25 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
26 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
27 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1
28 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1
29 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Mydriatics Phase 4,Phase 3,Phase 2
32 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
36 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
37 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
39 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1
40 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
41 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
42 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
43 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
44 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
45 Hormones Phase 4,Phase 3,Phase 2,Phase 1
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
47
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
48 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
49 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
50 Ergocalciferols Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 281)

id Name Status NCT ID Phase Drugs
1 Home Oxygen Therapy in Bronchiolitis Unknown status NCT01216553 Phase 4
2 Bronchiolitis All-study, SE-Norway Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
3 Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department Unknown status NCT01660867 Phase 4 3% saline + oral placebo;0.9% saline + oral dexamethasone
4 Efficacy and Safety of 3% Hypertonic Saline Inhalation (24h vs 72h) to Treat Acute Bronchiolitis in Hospitalized Infants Unknown status NCT02538458 Phase 4 3 % hypertonic saline up to 72H;3 % hypertonic saline up to 24H
5 Effect of Vitamin D Supplementation in Young South African Children Hospitalized With Acute Lower Respiratory Infection Unknown status NCT02054182 Phase 4 Vitamin D
6 Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion Unknown status NCT01353105 Phase 4
7 Nebulized 5% Hypertonic Saline for the Treatment of Bronchiolitis Completed NCT01016249 Phase 4 Treatment 1. (5% Hypertonic saline + Epinephrine);Treatment 3. (3% Hypertonic saline + Epinephrine);Treatment 2. (Normal saline + Epinephrine)
8 Epinephrine, Dexamethasone, and Hypertonic Saline in Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety Completed NCT01834820 Phase 4 Epinephrine and Dexamethasone;Hypertonic Saline;Normal Saline
9 7% Hypertonic Saline for Acute Bronchiolitis Completed NCT01871857 Phase 4 Hypertonic saline and epinephrine;Normal saline and epinephrine
10 Effectiveness of Nebulized Hypertonic Saline and Epinephrine in Hospitalized Infants With Bronchiolitis Completed NCT01300325 Phase 4
11 Glucocorticoid Therapy Impact on the Inflammatory Response and Clinical Evolution in Patients With Severe Bronchiolitis Completed NCT02571517 Phase 4 Glucocorticoids
12 Efficacy of Nebulised Hypertonic Saline (3%) Among Children With Bronchiolitis. Completed NCT01276821 Phase 4 L-Epinephrine and Normal Saline (0.9%);L-Epinephrine and Hypertonic Saline (3%)
13 Hypertonic Saline for Acute Bronchiolitis Completed NCT01247064 Phase 4 Nebulized 3% saline;Nebulized 0.9% Normal Saline
14 Impact of Oximetry on Hospitalization in Acute Bronchiolitis Completed NCT00673946 Phase 4
15 Bronchodilator Responsiveness in Obliterative Bronchiolitis Completed NCT01112241 Phase 4 albuterol plus tiotropium
16 Vitamin D in Bronchiolitis Obliterans Syndrome Completed NCT01212406 Phase 4 Vitamin D
17 Montelukast in Bronchiolitis Obliterans Syndrome Completed NCT01211509 Phase 4 Montelukast
18 Nebulized 3% Hypertonic Saline Solution Treatment of Bronchiolitis in Infants Completed NCT02233985 Phase 4 0.9% Sodium Chloride;3% Sodium Chloride
19 Use of Erythromycin in Mustard-Induced Bronchiolitis Completed NCT00367419 Phase 4 Erythromycin
20 The Effectiveness of Oral Dexamethasone for Acute Bronchiolitis Completed NCT00119002 Phase 4 dexamethasone;Placebo
21 Azithromycin in Bronchiolitis Obliterans Syndrome Completed NCT01009619 Phase 4 Azithromycin;Placebo
22 Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation Completed NCT01109160 Phase 4 Azithromycin Dihydrate
23 Safety Study of Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS) Completed NCT01469364 Phase 4 Aztreonam Lysine for Inhalation (AZLI)
24 Chronic Bronchiolitis or Resistant Asthma? Completed NCT00368342 Phase 4 Erythromycin, Azithromycin , Clarithromycin
25 Comparison of Sirolimus and Azathioprine in Lung Transplantation Completed NCT00321906 Phase 4 azathioprine;sirolimus
26 High Flow Nasal Cannula vs Low Flow Oxygen Therapy in Bronchiolitis Recruiting NCT03015051 Phase 4 Oxygen
27 Comparison of High Flow Oxygenation Therapy and CPAP in Children With Bronchiolitis. Recruiting NCT02618213 Phase 4
28 Efficacy of Intermittent Tiotropium in Early Childhood Wheezing Recruiting NCT03199976 Phase 4 Tiotropium Bromide;Fluticasone Propionate;Salbutamol
29 Assessment of Thoracic Echography for Pleuroparenchymatous Anomaly Diagnosis Complicating Bronchiolitis: BronchioIUS Not yet recruiting NCT02890797 Phase 4
30 Macitentan in the Treatment of Organ Rejection After Lung Transplantation Not yet recruiting NCT02893176 Phase 4 macitentan;placebo (for macitentan)
31 Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study Terminated NCT00361452 Phase 4 nebulized epinephrine and nebulized albuterol
32 Heliox-Driven Racemic Epinephrine Nebulization in Treatment of Moderate to Severe Bronchiolitis in Pediatric ED Patients Completed NCT00116584 Phase 3 heliox
33 An Investigational Drug Study to Treat Respiratory Symptoms Associated With Respiratory Syncytial Virus (RSV) Bronchiolitis (0476-272) Completed NCT00076973 Phase 3 montelukast sodium;Comparator: placebo
34 Nebulized Hypertonic Saline for Bronchiolitis Completed NCT00619918 Phase 2, Phase 3 Nebulized 3% saline;Placebo
35 Single Dose Versus Multiple Doses of Dexamethasone in Children With Acute Bronchiolitis Completed NCT00213226 Phase 3 dexamethasone
36 Nasal Irrigation in Infants With Bronchiolitis. Completed NCT02162745 Phase 3 Isotonic solution (NaCl 0.9%);Hypertonic solution (NaCl 3%)
37 Safety Study of Home Oxygen Therapy for Children With Acute Bronchiolitis Completed NCT00677066 Phase 3
38 The SABRE Trial of Hypertonic Saline in Acute Bronchiolitis Completed NCT01469845 Phase 3
39 Efficacy of Zinc in the Treatment of Bronchiolitis and Prevention of Wheezing Respiratory Illness in Children Less Than Two Years Old Completed NCT00355043 Phase 3 Zinc sulphate 20 mg
40 High Flow Therapy vs Hypertonic Saline in Bronchiolitis Completed NCT01873144 Phase 3 Epinephrine 1/1000;HSS 3%;NS (0.9%)
41 Moderate to Severe Bronchiolitis: Standard Therapy Versus Therapy With NaCl 3% Inhalations Completed NCT01812525 Phase 3 NaCl 3%
42 The Use of an Inhaled Salt Solution to Treat Viral Lung Infections in Infants. Completed NCT00151905 Phase 2, Phase 3 3 % hypertonic saline
43 Effect of Heliox on RSV Bronchiolitis Completed NCT03171142 Phase 3 Heliox;Air
44 Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis Completed NCT01777347 Phase 3 3% Saline;0.9% Normal Saline
45 Tacrolimus Versus Cyclosporine for Immunosuppression After Lung Transplantation Completed NCT01429844 Phase 3 Tacrolimus;Cyclosporine
46 Use of Clarithromycin in Mustard-Induced Bronchiolitis Completed NCT00381147 Phase 3 Clarithromycin
47 Study of Cyclosporine Inhalation Solution (CIS) in Improving Bronchiolitis Obliterans Syndrome-Free Survival Following Lung Transplantation Completed NCT00755781 Phase 3 Cyclosporine Inhalation Solution (CIS)
48 Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Prevention of Acute Rejection and Bronchiolitis Obliterans in Lung Transplant Completed NCT00188825 Phase 3 basiliximab
49 Furosemide Inhalation in Dyspnea of Mustard Gas Exposed Patients Completed NCT00512811 Phase 3 furosemide
50 Effect of Supplementation With Vitamin D on the Acute Bronchitis Prevention During the First Year of Life Completed NCT01875757 Phase 3 Vitamin D3;Placebo

Search NIH Clinical Center for Bronchiolitis

Cochrane evidence based reviews: bronchiolitis

Genetic Tests for Bronchiolitis

Anatomical Context for Bronchiolitis

MalaCards organs/tissues related to Bronchiolitis:

39
Lung, Bone, Bone Marrow, Skin, Breast, Heart, T Cells

Publications for Bronchiolitis

Articles related to Bronchiolitis:

(show top 50) (show all 1476)
id Title Authors Year
1
Bronchiolitis Obliterans (Obliterative Bronchiolitis, Constrictive Bronchiolitis) ( 28722895 )
2017
2
Eosinophilic Bronchiolitis. ( 28914741 )
2017
3
Clinical Analysis of Unicentric Castleman's Disease with Paraneoplastic Pemphigus and Bronchiolitis Obliterans. ( 28877826 )
2017
4
Repeated systemic administration of adipose tissue-derived mesenchymal stem cells prevents tracheal obliteration in a murine model of bronchiolitis obliterans. ( 28528427 )
2017
5
Dynamic oropharyngeal and faecal microbiota during treatment in infants hospitalized for bronchiolitis compared with age-matched healthy subjects. ( 28900158 )
2017
6
Cathelicidin (LL-37) and human I^2-defensin levels of children with post-infectious bronchiolitis obliterans. ( 26073571 )
2017
7
Mycoplasma pneumoniae-Associated Bronchiolitis Obliterans Following Acute Bronchiolitis. ( 28814783 )
2017
8
Clinical definition of respiratory viral infections in young children and potential bronchiolitis misclassification. ( 28947640 )
2017
9
Impact of Forced Expiratory Volume in 1 Second (FEV1) and 6-Minute Walking Distance at 3, 6, and 12 Months and Annually on Survival and Occurrence of Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation. ( 28871078 )
2017
10
Viral bronchiolitis in young infants: new perspectives for management and treatment. ( 28859915 )
2017
11
IL-8/IL-17 gene variations and the susceptibility to severe viral bronchiolitis. ( 27890033 )
2017
12
Respiratory Syncytial Virus Bronchiolitis in Children. ( 28084708 )
2017
13
Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis. ( 28471975 )
2017
14
A case of bronchiolitis obliterans organising pneumonia associated with SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome. ( 28765183 )
2017
15
Continuous Positive Airway Pressure in Bronchiolitis: A Randomized Controlled Trial. ( 28952459 )
2017
16
Clinical Factors Associated With Chest Imaging Findings in Hospitalized Infants With Bronchiolitis. ( 28871880 )
2017
17
Achievement of the longest survival of paraneoplastic pemphigus with bronchiolitis obliterans associated with follicular lymphoma using R-CHOP chemotherapy. ( 28791608 )
2017
18
Respiratory bronchiolitis-associated interstitial lung disease - an unexpected form of idiopathic interstitial pneumonia in a young male. ( 28523329 )
2017
19
Constrictive Bronchiolitis Attributable to Inhalation of Toxic Agents: Considerations for a Case Definition. ( 28953074 )
2017
20
Bronchiolitis obliterans syndrome in adults after allogeneic stem cell transplantation-pathophysiology, diagnostics and treatment. ( 28052713 )
2017
21
High-flow oxygen in bronchiolitis. ( 28855228 )
2017
22
SGEM Hot Off the Press: Management of bronchiolitis in community hospitals. ( 28905693 )
2017
23
Treatment methods for respiratory syncytial virus bronchiolitis need to be evaluated before they are introduced on a large scale. ( 28945290 )
2017
24
Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation. ( 28752350 )
2017
25
IL-17 contributes to the pathogenesis of obliterative bronchiolitis via regulation of M1 macrophages polarization in murine heterotopic trachea transplantation models. ( 28863322 )
2017
26
Temporal Changes in Prescription of Neuropharmacologic Drugs and Utilization of Resources Related to Neurologic Morbidity in Mechanically Ventilated Children With Bronchiolitis. ( 28930813 )
2017
27
The Calculated Risk of Childhood Asthma From Severe Bronchiolitis. ( 28065346 )
2017
28
Multivariate modeling using quantitative CT metrics may improve accuracy of diagnosis of bronchiolitis obliterans syndrome after lung transplantation. ( 28850899 )
2017
29
Serum miRNAs as potential biomarkers for the bronchiolitis obliterans syndrome after lung transplantation. ( 28457921 )
2017
30
Therapy options for chronic lung allograft dysfunction-bronchiolitis obliterans syndrome following first-line immunosuppressive strategies: A systematic review. ( 28662986 )
2017
31
Respiratory reactance in children aged three to fiveA years with postinfectious bronchiolitis obliterans is higher than in those with asthma. ( 27743492 )
2017
32
Effects of Intraperitoneal Injection of Allogeneic Bone Marrow-derived Mesenchymal Stem Cells on Bronchiolitis Obliterans in Mice Model. ( 28732434 )
2017
33
MicroRNA-218 acts by repressing TNFR1-mediated activation of NF-I_B, which is involved in MUC5AC hyper-production and inflammation in smoking-induced bronchiolitis of COPD. ( 28864214 )
2017
34
Initial use of high-flow oxygen did not reduce duration of oxygen therapy in infants with bronchiolitis. ( 28866617 )
2017
35
Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children. ( 28567534 )
2017
36
Effect of Rituximab on Pulmonary Function in Bronchiolitis Obliterans Syndrome due to Graft-Versus-Host-Disease. ( 28894914 )
2017
37
Chest computed tomography in bronchiolitis obliterans after bone marrow transplantation. ( 28670041 )
2017
38
Humidified high-flow nasal cannula oxygen for bronchiolitis: should we go with the flow? ( 28903952 )
2017
39
Development of a Multivariate Prediction Model for Early-Onset Bronchiolitis Obliterans Syndrome and Restrictive Allograft Syndrome in Lung Transplantation. ( 28770204 )
2017
40
Bronchiolitis: A Practical Approach for the General Radiologist-Erratum. ( 28898183 )
2017
41
Efficacy of Extracorporeal Photopheresis in Patients With Bronchiolitis Obliterans Syndrome After Lung Transplantation. ( 28457374 )
2017
42
An autopsy case of bronchiolitis obliterans as a previously unrecognized adverse event of afatinib treatment. ( 28012496 )
2017
43
Neurologic and Functional Morbidity in Critically Ill Children With Bronchiolitis. ( 28930814 )
2017
44
LTB4 and montelukast in transplantation-related bronchiolitis obliterans in rats. ( 28545478 )
2017
45
Early extracellular matrix changes are associated with later development of bronchiolitis obliterans syndrome after lung transplantation. ( 28469930 )
2017
46
Development of bronchiolitis obliterans organizing pneumonia during standard treatment of hepatitis C with Peg-IFNI+2b. ( 28823117 )
2017
47
The Role of Human Coronaviruses in Children Hospitalized for Acute Bronchiolitis, Acute Gastroenteritis, and Febrile Seizures: A 2-Year Prospective Study. ( 27171141 )
2016
48
Nebulised hypertonic saline inhalations do not shorten hospital stays in infants with bronchiolitis. ( 27111485 )
2016
49
Viral Bronchiolitis in Children. ( 27144865 )
2016
50
Diagnosis and management of bronchiolitis obliterans syndrome following lung or hematopoietic cell transplantation. ( 26950825 )
2016

Variations for Bronchiolitis

Expression for Bronchiolitis

Search GEO for disease gene expression data for Bronchiolitis.

Pathways for Bronchiolitis

Pathways related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 CCL11 CCL3 CCL5 CXCL8 IFNG IGHE
2
Show member pathways
13.94 CCL11 CCL3 CCL5 CXCL8 IL10 IL13
3
Show member pathways
13.81 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
4
Show member pathways
13.69 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
5
Show member pathways
13.52 CCL11 CCL3 CCL5 CXCL8 IFNG IGHE
6
Show member pathways
13.46 CCL11 CCL3 CCL5 CXCL8 IL10 IL13
7
Show member pathways
13.39 CCL11 CCL3 CCL5 CXCL8 IL10 IL13
8
Show member pathways
13.32 IFNG IL4 IL4R TLR1 TLR10 TLR4
9
Show member pathways
13.17 CCL5 CXCL8 IL6 MUC5B TLR1 TLR10
10
Show member pathways
13.07 CCL3 CCL5 CXCL8 IFNG IL10 IL6
11
Show member pathways
13.04 CCL11 CXCL8 IFNG IL10 IL13 IL4
12
Show member pathways
12.99 CCL5 CXCL8 IFNG IL13 IL4 IL6
13
Show member pathways
12.82 IL6 TLR1 TLR10 TLR4 TLR9 TNF
14
Show member pathways
12.8 IFNG IL10 IL13 IL4 IL4R IL5
15
Show member pathways
12.78 CCL5 CXCL8 IFNG IL6 TNF
16
Show member pathways
12.75 IFNG IGHE IL10 IL4 IL4R TNF
17 12.72 CCL5 IFNG IL10 IL4 TLR1 TLR9
18
Show member pathways
12.67 TLR1 TLR10 TLR4 TLR9 TNF
19
Show member pathways
12.67 IGHE IL13 IL4 IL5 TNF
20
Show member pathways
12.59 IFNG IL10 IL4 IL5 IL6 TNF
21
Show member pathways
12.51 CCL11 CXCL8 IFNG IL13 IL4 IL5
22 12.44 IFNG IL10 IL6 TLR1 TLR4 TLR9
23
Show member pathways
12.43 CCL11 IGHE IL4 IL4R
24
Show member pathways
12.42 IFNG IL10 IL13 IL4 IL4R IL5
25
Show member pathways
12.41 CXCL8 IFNG IL6 TLR4 TNF
26
Show member pathways
12.39 IFNG IL10 IL4 TLR4 TNF
27 12.39 IFNG IL6 TLR1 TLR10 TLR4 TLR9
28
Show member pathways
12.35 CXCL8 IFNG IL10 IL13 IL4 IL5
29 12.32 CXCL8 IL10 IL13 IL6 TNF
30
Show member pathways
12.3 CCL11 CXCL8 IFNG IL4 IL6 TLR1
31
Show member pathways
12.24 IL13 IL5 TLR1 TLR10 TLR4 TLR9
32 12.23 CXCL8 IFNG IL4 IL6 TLR4 TNF
33 12.21 IFNG IL10 IL4 IL5 IL6 TNF
34 12.16 TLR1 TLR10 TLR4 TLR9
35
Show member pathways
12.13 IFNG IL10 IL6 TLR1 TLR10 TLR4
36
Show member pathways
12.12 CCL11 CCL3 CCL5 CXCL8
37 12.11 CXCL8 IFNG IL10 IL6 TLR4 TNF
38 12.08 IL4 IL4R IL5 IL6 TNF
39 12.08 CCL3 CCL5 CXCL8 IFNG IL6 TLR4
40 12.06 CCL3 CXCL8 IFNG IL6
41 12.03 CCL3 CXCL8 IFNG IL6 TLR4
42 12.02 CXCL8 IFNG IL13 IL4 IL5 IL6
43 12.01 CCL3 IFNG IL10 IL13 IL4 IL5
44
Show member pathways
12.01 IFNG IL4 IL4R IL6 TLR1 TLR10
45 11.98 IFNG IL10 IL4R IL6
46
Show member pathways
11.97 CXCL8 IFNG IL4 IL5 TNF
47 11.97 CXCL8 IL10 IL6 TLR4 TNF
48 11.96 IFNG IL10 IL6 TLR9 TNF
49 11.95 TLR1 TLR10 TLR4 TLR9
50 11.94 IL10 IL4 IL5 IL6 TLR4 TLR9

GO Terms for Bronchiolitis

Cellular components related to Bronchiolitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 CCL11 CCL3 CCL5 CXCL8 IFNG IGHE
2 external side of plasma membrane GO:0009897 9.7 IFNG IGHE IL13 IL4 IL6 TLR4
3 extracellular space GO:0005615 9.5 CCL11 CCL3 CCL5 CXCL8 IFNG IL10

Biological processes related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 97)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.98 IL10 IL4 IL5 IL6 TNF
2 chemokine-mediated signaling pathway GO:0070098 9.97 CCL11 CCL3 CCL5 CXCL8
3 positive regulation of inflammatory response GO:0050729 9.96 CCL3 TLR10 TLR4 TLR9
4 positive regulation of T cell proliferation GO:0042102 9.96 CCL5 IFNG IL4 IL6
5 cellular response to lipopolysaccharide GO:0071222 9.95 CXCL8 IFNG IL10 IL6 TLR4 TNF
6 movement of cell or subcellular component GO:0006928 9.94 CXCL8 IFNG IL13
7 cellular response to organic cyclic compound GO:0071407 9.94 CCL3 CCL5 TNF
8 positive regulation of JNK cascade GO:0046330 9.94 TLR4 TLR9 TNF
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.94 CCL5 IL13 IL6 TNF
10 response to glucocorticoid GO:0051384 9.93 IL10 IL6 TNF
11 regulation of insulin secretion GO:0050796 9.93 CCL5 IFNG TNF
12 positive regulation of tumor necrosis factor production GO:0032760 9.93 CCL3 IFNG TLR4 TLR9
13 cellular response to interleukin-1 GO:0071347 9.93 CCL11 CCL3 CCL5 CXCL8 IL6
14 response to cytokine GO:0034097 9.92 CCL5 IL4 IL6
15 cellular response to interferon-gamma GO:0071346 9.92 CCL11 CCL3 CCL5
16 positive regulation of interleukin-6 production GO:0032755 9.92 IL6 TLR4 TLR9 TNF
17 neutrophil chemotaxis GO:0030593 9.92 CCL11 CCL3 CCL5 CXCL8 IFNG
18 humoral immune response GO:0006959 9.91 IFNG IL6 TNF
19 toll-like receptor signaling pathway GO:0002224 9.91 TLR1 TLR10 TLR4 TLR9
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.91 IFNG IL6 TLR4 TNF
21 positive regulation of cell adhesion GO:0045785 9.9 CCL5 IFNG TNF
22 protein kinase B signaling GO:0043491 9.89 CCL3 CCL5 TNF
23 monocyte chemotaxis GO:0002548 9.89 CCL11 CCL3 CCL5 IL6
24 negative regulation of endothelial cell apoptotic process GO:2000352 9.88 IL10 IL13 IL4
25 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.88 TLR1 TLR10 TLR4 TLR9
26 positive regulation of interleukin-8 production GO:0032757 9.87 TLR4 TLR9 TNF
27 positive regulation of interleukin-12 production GO:0032735 9.87 IFNG TLR4 TLR9
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.87 CCL3 CCL5 TLR4 TNF
29 positive regulation of interleukin-10 production GO:0032733 9.86 IL4 TLR4 TLR9
30 negative regulation of osteoclast differentiation GO:0045671 9.86 CCL3 IL4 TLR4
31 positive regulation of NF-kappaB import into nucleus GO:0042346 9.86 TLR4 TLR9 TNF
32 immune response GO:0006955 9.86 CCL11 CCL3 CCL5 CXCL8 IFNG IGHE
33 defense response to Gram-negative bacterium GO:0050829 9.85 IL6 TLR4 TLR9
34 positive regulation of JAK-STAT cascade GO:0046427 9.85 CCL5 IL5 IL6
35 negative regulation of interleukin-6 production GO:0032715 9.85 IL10 TLR4 TLR9 TNF
36 positive regulation of B cell activation GO:0050871 9.84 IGHE IL4 IL6
37 negative regulation of growth of symbiont in host GO:0044130 9.84 IFNG IL10 TNF
38 response to molecule of bacterial origin GO:0002237 9.82 CXCL8 IL10 TLR9
39 positive regulation of mast cell degranulation GO:0043306 9.81 IL13 IL4 IL4R
40 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 CCL5 IFNG IL4 IL6
41 positive regulation of chemokine biosynthetic process GO:0045080 9.8 IFNG IL4 TNF
42 positive regulation of chemokine production GO:0032722 9.8 IL6 TLR4 TLR9 TNF
43 eosinophil chemotaxis GO:0048245 9.79 CCL11 CCL3 CCL5
44 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.78 IL10 TNF
45 I-kappaB phosphorylation GO:0007252 9.77 TLR4 TLR9
46 positive regulation of immunoglobulin secretion GO:0051024 9.77 IL5 IL6
47 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.77 CCL5 CXCL8
48 negative regulation by host of viral transcription GO:0043922 9.77 CCL3 CCL5
49 positive regulation of protein import into nucleus, translocation GO:0033160 9.77 IFNG IL6
50 positive regulation of podosome assembly GO:0071803 9.77 IL5 TNF

Molecular functions related to Bronchiolitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 IL10 IL4 IL5 IL6
2 phospholipase activator activity GO:0016004 9.37 CCL3 CCL5
3 cytokine activity GO:0005125 9.36 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
4 CCR5 chemokine receptor binding GO:0031730 9.32 CCL3 CCL5
5 chemokine activity GO:0008009 9.26 CCL11 CCL3 CCL5 CXCL8
6 CCR1 chemokine receptor binding GO:0031726 9.16 CCL3 CCL5

Sources for Bronchiolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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