MCID: BRN012
MIFTS: 59

Bronchiolitis Obliterans malady

Summaries for Bronchiolitis Obliterans

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Bronchiolitis obliterans is an inflammatory obstruction of the lung's tiniest airways, the bronchioles. the bronchioles may become damaged and inflamed after inhalation of toxic fumes, as a result of respiratory infections, in association with connective tissue disorders, or after bone marrow or heart-lung transplants. this leads to extensive scarring that blocks the airways, leading to a dry cough, shortness of breath, fatigue and wheezing in the absence of a cold or asthma. while there is no way to reverse the disease, treatments are available to stabilize or slow the progression.   another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease. last updated: 10/1/2012

MalaCards: Bronchiolitis Obliterans, also known as bronchiolitis fibrosa obliterans, is related to bronchiolitis and pneumonia. An important gene associated with Bronchiolitis Obliterans is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are Chemokine receptors bind chemokines and CXCR3-mediated signaling events. The compounds endotoxin and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow, and related mouse phenotypes are respiratory system and immune system.

Disease Ontology:8 A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults.

Wikipedia:63 Bronchiolitis obliterans (BO), also called obliterative bronchiolitis (OB) and constrictive... more...

Aliases & Classifications for Bronchiolitis Obliterans

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

bronchiolitis obliterans 8 42 10 44 30 60
bronchiolitis fibrosa obliterans 8 60
obliterative bronchiolitis 8 42
bronchiolitis, exudative 60
bronchiolitis exudativa 8


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Disease Ontology8 DOID:2799
MeSH34 D001989
SNOMED-CT56 40100001, 31886003
NCIt39 C62580

Related Diseases for Bronchiolitis Obliterans

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17GeneCards, 18GeneDecks
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Diseases related to Bronchiolitis Obliterans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 237)
idRelated DiseaseScoreTop Affiliating Genes
1bronchiolitis32.3IL8
2pneumonia32.0HMOX1, MMP8, IL17A, IL8, CXCL10, CRP
3bronchiolitis obliterans organizing pneumonia32.0TOMM5
4cryptogenic organizing pneumonia31.0TOMM5
5arthritis30.9IL8, CRP, ALB, MMP8, CXCR3, CXCL10
6rheumatoid arthritis30.9CXCL10, CXCR3, SFTPD, BMP6, CRP, IL8
7systemic lupus erythematosus30.8CRP, IL17A, CXCR3, CXCL10
8cystic fibrosis30.7HMOX1, IL8, SCGB1A1, SFTPD, IL17A, ALB
9leukemia30.7CXCR3, IL17A, HMOX1, IFNA2, SCGB1A1, PDGFB
10ulcerative colitis30.7CRP, IL17A, IL8, CXCL10, CXCR3
11breast cancer30.7ALB, CXCL10, MMP8, SCGB1A1, IL17A, BMP6
12sarcoidosis30.6SFTPD, CXCL10, CXCR3, SCGB1A1, PDGFB
13lung cancer30.6SFTPD, MMP8, PDGFB, SCGB1A1, CHKA, CXCR3
14respiratory failure30.5SFTPD, PIK3C2A
15pulmonary fibrosis30.5IL8, BMP6, SFTPD, HMOX1, PDGFB, CXCR3
16tuberculosis30.5SFTPD, IL17A, CXCR3, ALB, CRP, CXCL10
17dermatomyositis30.4IL17A, SFTPD, PIK3C2A, CHKA
18ischemia30.4PDGFB, HMOX1, IL17A, CHKA, PIK3C2A
19hepatitis30.4ALB, PDGFB, CXCL10, IFNA2
20malaria30.1ALB
21cholangitis30.1ALB
22acquired immunodeficiency syndrome30.1ALB
23aspergillosis30.1SFTPD
24pancreatitis30.1CRP, ALB
25hypertension30.1CRP, ALB
26bronchitis30.1CRP
27herpes simplex30.1CXCL10
28bronchiectasis30.1IL8, MMP8
29influenza30.1CXCL10, SFTPD, CXCR3
30myopathy30.1CRP, PIK3C2A, CHKA
31hepatitis b30.1ALB, IFNA2, CXCL10, IL17A
32interstitial lung disease30.1PDGFB, BMP6, SFTPD, IL8
33cryoglobulinemia30.1IFNA2
34pulmonary sarcoidosis30.1PDGFB, SFTPD, CXCR3
35asthma30.1CXCR3, SFTPD, SCGB1A1, CXCL10, IL8, IL17A
36idiopathic pulmonary fibrosis30.1SFTPD, PDGFB, SCGB1A1, BMP6, CXCR3, CXCL10
37acute leukemia30.1IL17A
38hepatitis c30.1CXCR3, IFNA2, CXCL10
39pemphigus10.7
40graft versus host disease10.6
41lupus erythematosus10.6
42pneumothorax10.5
43eosinophilic pneumonia10.5
44chronic eosinophilic pneumonia10.4
45stevens-johnson syndrome10.3
46aspiration pneumonia10.3
47hodgkin's lymphoma10.3
48scleroderma10.3
49bronchiolitis obliterans with obstructive pulmonary disease10.3
50acute interstitial pneumonia10.3

Graphical network of the top 20 diseases related to Bronchiolitis Obliterans:



Diseases related to bronchiolitis obliterans

Clinical Features for Bronchiolitis Obliterans

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Drugs & Therapeutics for Bronchiolitis Obliterans

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Bronchiolitis Obliterans

Search CenterWatch for Bronchiolitis Obliterans

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bronchiolitis Obliterans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchiolitis Obliterans:
Mesenchymal stem cells for obliterative bronchiolitis
Embryonic/Adult Cultured Cells Related to Bronchiolitis Obliterans:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Bronchiolitis Obliterans

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Anatomical Context for Bronchiolitis Obliterans

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Bronchiolitis Obliterans:

32
Lung, Bone, Bone marrow, Heart, Breast, T cells, Liver, Colon, B cells, Testes, Kidney, Thyroid, Smooth muscle, Thymus, Trachea

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bronchiolitis Obliterans:
id TissueAnatomical CompartmentCell Relevance
1 LungRespiratory BronchiolesCilliated Cells Potential therapeutic candidate, affected by disease

Animal Models for Bronchiolitis Obliterans or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bronchiolitis Obliterans:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.3CXCR3, TOMM5, SCGB1A1, SFTPD
2MP:000538710.0SFTPD, MMP8, IL17A, IL8, CXCL10, CXCR3
3MP:000536710.0PDGFB, SCGB1A1, PIK3C2A, IL17A, HMOX1
4MP:00107689.9MAPKAP1, SFTPD, ALB, HMOX1, IL17A, CXCL10
5MP:00053769.9PIK3C2A, SCGB1A1, PDGFB, SFTPD, CRP, CHKA

Publications for Bronchiolitis Obliterans

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50PubMed
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Articles related to Bronchiolitis Obliterans:

(show top 50)    (show all 697)
idTitleAuthorsYear
1
Elevated peptides in lung lavage fluid associated with bronchiolitis obliterans syndrome. (24392140)
2014
2
Propylthiouracil-induced bronchiolitis obliterans organizing pneumonia. (24292758)
2013
3
Rattus model utilizing selective pulmonary ischemia induces bronchiolitis obliterans organizing pneumonia. (23364425)
2013
4
Bronchiolitis obliterans syndrome leads to a functional deterioration of the acinus post lung transplant. (24212890)
2013
5
Bronchiolitis obliterans organizing pneumonia following nitric acid fume exposure. (24319049)
2013
6
Rapid acute onset of bronchiolitis obliterans syndrome in a lung transplant recipient after respiratory syncytial virus infection. (22650803)
2012
7
Bronchiolitis obliterans syndrome is associated with increased peripheral blood natural killer and natural killer T-like granzymes, perforin, and T-helper-type 1 pro-inflammatory cytokines. (22759800)
2012
8
Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. (22869493)
2012
9
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. (22072556)
2012
10
Bortezomib-induced bronchiolitis obliterans organizing pneumonia. (23133779)
2012
11
Increased plasma mannose binding lectin levels are associated with bronchiolitis obliterans after lung transplantation. (22762710)
2012
12
A Case of Balsalazide-Induced Limited Form of Granulomatosis with Polyangiitis with Bronchiolitis Obliterans Organizing Pneumonia-like Variant in Ulcerative Colitis. (23227073)
2012
13
Azithromycin and bronchiolitis obliterans syndrome after lung transplantation: is prevention better than cure? (21205711)
2011
14
Post-infectious bronchiolitis obliterans in children. (21547332)
2011
15
Successful extracorporeal life support for life-threatening hypercapnia with bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. (22189481)
2011
16
Preventing and managing bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplantation. (21348593)
2011
17
Increased oxidative stress in children with post infectious Bronchiolitis Obliterans. (21208718)
2011
18
HBs seroconversion in a patient with acute hepatitis B treated with entecavir during immunosuppression against severe bronchiolitis obliterans in the course of chronic graft versus host disease. (20403727)
2010
19
Local IL-17 production and a decrease in peripheral blood regulatory T cells in an animal model of bronchiolitis obliterans. (20393404)
2010
20
Tolerability of pravastatin in pediatric hematopoietic stem cell transplant patients with bronchiolitis obliterans. (20186101)
2010
21
The contribution of airway ischemia and vascular remodelling to the pathophysiology of bronchiolitis obliterans syndrome and chronic lung allograft dysfunction. (20693899)
2010
22
Noninvasive diagnosis of bronchiolitis obliterans due to sulfur mustard exposure: could high-resolution computed tomography give us a clue? (20119854)
2010
23
Mycophenolate mofetil reduces alveolar inflammation, acute rejection and graft loss due to bronchiolitis obliterans syndrome after lung transplantation. (20394831)
2010
24
Azithromycin is associated with increased survival in lung transplant recipients with bronchiolitis obliterans syndrome. (20133163)
2010
25
Living-donor single lobe lung transplantation for bronchiolitis obliterans from mother to child following previous allogeneic hematopoietic stem cell transplantation from the same donor. (19866336)
2009
26
The value of D-dimer in lung transplant recipients with bronchiolitis obliterans syndrome. (17976973)
2008
27
A survey of radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy in Japan. (18060702)
2008
28
Prognostic value of serum surfactant protein D level prior to transplant for the development of bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation. (18347569)
2008
29
Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings. (17541015)
2007
30
IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. (17182591)
2007
31
Course of FEV(1) after onset of bronchiolitis obliterans syndrome in lung transplant recipients. (17347496)
2007
32
Elevated soluble CD30 correlates with development of bronchiolitis obliterans syndrome following lung transplantation. (17198242)
2006
33
Reversible severe air leak syndrome in a child with bronchiolitis obliterans after allogeneic stem cell transplantation. (16525828)
2006
34
Risk factors for bronchiolitis obliterans in allogeneic hematopoietic stem-cell transplantation for leukemia. (16002929)
2005
35
Spontaneous pneumothorax after steroid treatment in a patient with bronchiolitis obliterans organizing pneumonia. (15818434)
2005
36
Aerosol cyclosporin therapy in lung transplant recipients with bronchiolitis obliterans. (15065826)
2004
37
Sweet's syndrome and bronchiolitis obliterans organizing pneumonia. (11460854)
2001
38
Dermatomyositis without elevation of creatine kinase presented as bronchiolitis obliterans organizing pneumonia. (10714098)
2000
39
Constrictive bronchiolitis obliterans and paraneoplastic pemphigus. (10362065)
1999
40
Bronchiolitis obliterans organizing pneumonia in Korea. (9767618)
1998
41
Bronchiolitis obliterans organizing pneumonia syndrome primed by radiation therapy to the breast. The Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERM"O"P) (9847288)
1998
42
Factors related to the relapse of bronchiolitis obliterans organizing pneumonia. (9872195)
1998
43
Bronchiolitis obliterans organizing pneumonia secondary to amiodarone: clinical, radiological and histological pattern. (9151516)
1997
44
Bronchiolitis obliterans organizing pneumonia and chronic graft-versus-host disease in a child after allogeneic bone marrow transplantation. (9134179)
1997
45
Bronchiolitis obliterans organizing pneumonia in a child with acquired immunodeficiency syndrome. (8724069)
1996
46
Crescentic and ring-shaped opacities. CT features in two cases of bronchiolitis obliterans organizing pneumonia (BOOP). (8995460)
1996
47
Bronchiolitis obliterans organizing pneumonia: definition and clinical features. (1623805)
1992
48
Bronchiolitis obliterans organizing pneumonia and rheumatoid arthritis. (1955014)
1991
49
Bronchiolitis obliterans organizing pneumonia: CT features in 14 patients. (2108572)
1990
50
Radiographic manifestations of bronchiolitis obliterans with organizing pneumonia vs usual interstitial pneumonia. (3490161)
1986

Genetic Variations for Bronchiolitis Obliterans

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Expression for genes affiliated with Bronchiolitis Obliterans

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bronchiolitis Obliterans

Search GEO for disease gene expression data for Bronchiolitis Obliterans.

Pathways for genes affiliated with Bronchiolitis Obliterans

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53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Bronchiolitis Obliterans

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.9SCGB1A1, CXCR3
2alpha tocopherol4410.8IFNA2, CHKA
3groalpha4410.7CXCL10, IL8, CXCR3, IL17A
4etanercept44 49 1112.7IL17A, CRP, CXCR3, IFNA2, IL8
5prednisolone44 28 1112.7IFNA2, SFTPD, CRP, PIK3C2A
6dexamethasone44 49 28 1113.7SFTPD, CHKA, BMP6, PDGFB
7rantes4410.7IL17A, MAPKAP1, BMP6, CXCR3
8infliximab44 49 1112.7IFNA2, CXCR3, CRP, IL17A, CXCL10
9glucose4410.7IFNA2, PIK3C2A, SFTPD, MMP8
10cyclosporin a44 28 5912.7HMOX1, IL17A, MMP8, PIK3C2A, PDGFB
11gamma globulin4410.7ALB, CRP, IFNA2
12oxygen44 2411.6PIK3C2A, SFTPD, SCGB1A1, IL8, MMP8, HMOX1
13vitamin a44 11 2412.6IFNA2, CHKA
14il 104410.6IL8, BMP6, CXCL10, CXCR3
15indomethacin44 59 28 1113.6HMOX1
16ifn-alpha4410.6IL17A, CXCR3, CXCL10, IFNA2
17superoxide44 2411.6CXCR3, CHKA, HMOX1, IFNA2, MMP8
18polyethylene glycol4410.6ALB, HMOX1, CRP, BMP6, IFNA2
19tacrolimus44 49 1112.6PDGFB, BMP6, CXCR3, CXCL10, IL17A, ALB
20neopterin4410.6IL8, CRP, CXCL10, IFNA2
21uric acid44 2411.6PIK3C2A, CHKA
22simvastatin44 49 59 28 11 2415.6BMP6, IL8, CHKA, CRP, PIK3C2A, HMOX1
23atorvastatin44 49 28 11 2414.6CHKA, CRP, PIK3C2A, HMOX1, BMP6
24aspartate4410.6SCGB1A1, ALB, CHKA, PIK3C2A, BMP6
25citrate4410.6ALB, PIK3C2A, CRP, CHKA, HMOX1
26ly2940024410.6BMP6, PIK3C2A, CXCR3, HMOX1, IL8, IL17A
27iron44 2411.6PIK3C2A, SCGB1A1, IFNA2, HMOX1
28histamine44 28 2412.6ALB, CXCL10, IL8, CXCR3, BMP6, IFNA2
29prostacyclin4410.5CRP, PDGFB, HMOX1, PIK3C2A, BMP6
30ascorbic acid44 2411.5CHKA, CRP, PIK3C2A, IFNA2, HMOX1, ALB
31thymidine44 2411.5CXCL10, BMP6, SFTPD, IFNA2, PDGFB, IL17A
32cycloheximide4410.5CXCL10, PDGFB
33progesterone44 59 28 11 2414.5MMP8, CXCL10, IFNA2, CXCR3, CHKA, PIK3C2A
34creatinine4410.5ALB, SCGB1A1, CRP, CHKA, CXCR3, CXCL10
35nitric oxide44 11 2412.5HMOX1, MMP8, IL17A, IL8, CXCR3, BMP6
36lactate4410.5PIK3C2A, ALB, SFTPD, BMP6, CRP, CHKA
37imiquimod44 28 59 1113.5IFNA2, IL8, BMP6
38methotrexate44 49 1112.5PIK3C2A, CRP, IL17A, ALB, BMP6
39phosphatidylinositol4410.5CXCR3, SFTPD, PIK3C2A, BMP6, CHKA, CXCL10
40alanine4410.4ALB, HMOX1, MMP8, CXCL10, CHKA, CRP
41vegf4410.4IL17A, CXCL10, CXCR3, CRP, PIK3C2A, BMP6
42steroid4410.4CXCR3, CHKA, PIK3C2A, IFNA2, SCGB1A1, IL17A
43cholesterol44 28 11 2413.4PIK3C2A, CRP, CHKA, CXCR3, CXCL10, ALB
44sb 20358044 5911.4HMOX1, IL17A, CRP, IL8, BMP6
45lipid4410.4MMP8, SFTPD, IFNA2, PDGFB, SCGB1A1, PIK3C2A
46sodium nitroprusside4410.3HMOX1, CXCR3, PIK3C2A, BMP6
47hydrocortisone44 2 59 1113.3IL8
48p0024410.3SCGB1A1, IL17A, CRP, MMP8
49acetylcholine44 49 28 11 2414.3CHKA, HMOX1, BMP6
50isoflurane44 1111.0PIK3C2A, ALB, HMOX1

GO Terms for genes affiliated with Bronchiolitis Obliterans

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16Gene Ontology
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Cellular components related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1IFNA2, PDGFB, CRP, CXCL10, IL8, MMP8
2extracellular spaceGO:0056159.7ALB, SFTPD, IFNA2, PDGFB, SCGB1A1, BMP6

Biological processes related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.2KIR2DS5, MAPKAP1, PDGFB, IFNA2, SFTPD
2inflammatory responseGO:00695410.1IL17A, IL8, CXCL10, CXCR3, CRP, BMP6
3immune responseGO:0069559.9BMP6, CXCL10, IL8, IL17A, KIR2DS5

Molecular functions related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1choline bindingGO:03326510.4CHKA, CRP

Products for genes affiliated with Bronchiolitis Obliterans

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Sources for Bronchiolitis Obliterans

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet