MCID: BRN012
MIFTS: 59

Bronchiolitis Obliterans malady

Rare diseases, Respiratory diseases categories

Summaries for Bronchiolitis Obliterans

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9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Bronchiolitis obliterans is an inflammatory obstruction of the lung's tiniest airways, the bronchioles. the bronchioles may become damaged and inflamed after inhalation of toxic fumes, as a result of respiratory infections, in association with connective tissue disorders, or after bone marrow or heart-lung transplants. this leads to extensive scarring that blocks the airways, leading to a dry cough, shortness of breath, fatigue and wheezing in the absence of a cold or asthma. while there is no way to reverse the disease, treatments are available to stabilize or slow the progression.   another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease. last updated: 10/1/2012

MalaCards: Bronchiolitis Obliterans, also known as bronchiolitis fibrosa obliterans, is related to bronchiolitis and pneumonia. An important gene associated with Bronchiolitis Obliterans is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are Selected targets of C EBPalpha and Cytokine production by Th17 cells in CF. The compounds p002 and mcp 1 have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow, and related mouse phenotypes are renal/urinary system and respiratory system.

Disease Ontology:9 A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults.

Wikipedia:66 Bronchiolitis obliterans (BO), also called obliterative bronchiolitis (OB) and constrictive... more...

Aliases & Classifications for Bronchiolitis Obliterans

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 32LifeMap Discovery™, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

bronchiolitis obliterans 9 44 11 46 32 63
bronchiolitis fibrosa obliterans 9 63
obliterative bronchiolitis 9 44
bronchiolitis, exudative 63
bronchiolitis exudativa 9


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Disease Ontology9 DOID:2799
MeSH36 D001989
SNOMED-CT59 40100001, 31886003
NCIt41 C62580

Related Diseases for Bronchiolitis Obliterans

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Bronchiolitis Obliterans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1bronchiolitis32.5IL8
2pneumonia32.0SCGB1A1, MMP8, CXCL10, IL17A, IL8
3arthritis31.0IL17A, IL8
4systemic lupus erythematosus30.9IL17A, CXCR3, CXCL10
5rheumatoid arthritis30.9MMP8, CXCL10, CXCR3, IL17A, IL8
6cystic fibrosis30.8SCGB1A1, IL17A, IL8
7ulcerative colitis30.7CXCL10, CXCR3, IL17A, IL8
8respiratory failure30.7SCGB1A1, CXCL10
9leukemia30.7SCGB1A1, CXCR3, IFNA2, IL17A, PDGFB
10sarcoidosis30.6PDGFB, CXCR3, CXCL10, SCGB1A1
11breast cancer30.6SCGB1A1, MMP8, CXCL10, CXCR3, IL17A
12tuberculosis30.5PDGFB, IL17A, CXCR3, CXCL10
13pulmonary fibrosis30.4CXCR3, IL8, PDGFB
14lung cancer30.4PDGFB, CXCR3, MMP8, SCGB1A1
15hepatitis30.4CXCL10, IFNA2, PDGFB
16bronchiectasis30.3MMP8, IL8
17pulmonary sarcoidosis30.3PDGFB, CXCR3
18hepatitis b30.2CXCL10, IFNA2, IL17A
19hepatitis c30.2IFNA2, CXCR3, CXCL10
20idiopathic pulmonary fibrosis30.1SCGB1A1, CXCL10, CXCR3, IL8, PDGFB
21asthma30.1SCGB1A1, MMP8, CXCL10, CXCR3, IL17A, IL8
22bronchiolitis obliterans organizing pneumonia11.4
23hematopoietic stem cell transplantation10.9
24pemphigus10.7
25paraneoplastic pemphigus10.7
26cryptogenic organizing pneumonia10.7
27graft versus host disease10.6
28lupus erythematosus10.6
29chronic graft versus host disease10.6
30pneumothorax10.5
31castleman's disease10.5
32usual interstitial pneumonia10.5
33chronic eosinophilic pneumonia10.5
34eosinophilic pneumonia10.5
35pulmonary function10.5
36stevens-johnson syndrome10.4
37hodgkin's lymphoma10.4
38scleroderma10.4
39polymyositis10.4
40bronchiolitis obliterans with obstructive pulmonary disease10.4
41acute interstitial pneumonia10.3
42juvenile rheumatoid arthritis10.3
43gastroesophageal reflux disease10.3
44measles10.3
45wegener's granulomatosis10.3
46dermatomyositis10.3
47ischemia10.3
48mediastinitis10.3
49b-cell lymphomas10.3
50spontaneous pneumothorax10.3

Graphical network of the top 20 diseases related to Bronchiolitis Obliterans:



Diseases related to bronchiolitis obliterans

Symptoms for Bronchiolitis Obliterans

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Drugs & Therapeutics for Bronchiolitis Obliterans

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discovery™, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Bronchiolitis Obliterans

Drug clinical trials:

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Search NIH Clinical Center for Bronchiolitis Obliterans

Search CenterWatch for Bronchiolitis Obliterans

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bronchiolitis Obliterans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchiolitis Obliterans:
Mesenchymal stem cells for obliterative bronchiolitis
Embryonic/Adult Cultured Cells Related to Bronchiolitis Obliterans:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Bronchiolitis Obliterans

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Anatomical Context for Bronchiolitis Obliterans

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32LifeMap Discovery™, 34MalaCards
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MalaCards organs/tissues related to Bronchiolitis Obliterans:

34
Lung, Bone, Bone marrow, Heart, Breast, T cells, Colon, Liver, B cells, Testes, Smooth muscle, Thymus, Thyroid, Kidney, Trachea

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bronchiolitis Obliterans:
id TissueAnatomical CompartmentCell Relevance
1 LungRespiratory BronchiolesCilliated Cells Potential therapeutic candidate, affected by disease

Animal Models for Bronchiolitis Obliterans or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Bronchiolitis Obliterans:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9SCGB1A1, CXCR3, IL17A, PDGFB
2MP:00053888.6SCGB1A1, CXCR3, IL17A, PDGFB
3MP:00053978.1PDGFB, IL8, IL17A, CXCR3, CXCL10
4MP:00107687.8SCGB1A1, CXCL10, CXCR3, IL17A, MAPKAP1, PDGFB
5MP:00053877.5PDGFB, IL8, IL17A, CXCR3, CXCL10, MMP8

Publications for Bronchiolitis Obliterans

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53PubMed
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Articles related to Bronchiolitis Obliterans:

(show top 50)    (show all 689)
idTitleAuthorsYear
1
Effects of prophylactic use of sirolimus on bronchiolitis obliterans syndrome development in lung transplant recipients. (24119986)
2014
2
Aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans. (23062110)
2013
3
Chest health surveillance utility in the early detection of bronchiolitis obliterans syndrome in children after allo-SCT. (23165500)
2013
4
A relevant experimental model for human bronchiolitis obliterans syndrome. (24050896)
2013
5
Risk factors for bronchiolitis obliterans syndrome in allogeneic hematopoietic stem cell transplantation. (23823823)
2013
6
Treatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model. (24199758)
2013
7
Bronchiolitis obliterans syndrome: the Achilles' heel of lung transplantation. (23821508)
2013
8
Heterotopic tracheal transplantation animal model of bronchiolitis obliterans: A reproducible model. (24309319)
2013
9
Rapid acute onset of bronchiolitis obliterans syndrome in a lung transplant recipient after respiratory syncytial virus infection. (22650803)
2012
10
Bronchiolitis obliterans syndrome is associated with increased peripheral blood natural killer and natural killer T-like granzymes, perforin, and T-helper-type 1 pro-inflammatory cytokines. (22759800)
2012
11
Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. (22869493)
2012
12
Radiation-induced bronchiolitis obliterans organizing pneumonia: a case report and literature review. (23187778)
2012
13
Histopathological bronchial reconstruction of human bronchiolitis obliterans. (21418391)
2011
14
HBs seroconversion in a patient with acute hepatitis B treated with entecavir during immunosuppression against severe bronchiolitis obliterans in the course of chronic graft versus host disease. (20403727)
2010
15
Local IL-17 production and a decrease in peripheral blood regulatory T cells in an animal model of bronchiolitis obliterans. (20393404)
2010
16
The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation. (20456980)
2010
17
Systemic and exhaled cytokine and chemokine profiles are associated with the development of bronchiolitis obliterans syndrome. (20627628)
2010
18
Air-leak and transient coronary artery dilation in post-infectious bronchiolitis obliterans. (20958871)
2010
19
Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease. (19896545)
2010
20
Clara cell secretory protein and surfactant protein-D do not predict bronchiolitis obliterans syndrome after lung transplantation. (20683434)
2010
21
The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation. (19299743)
2009
22
Effect of maintenance azithromycin on established bronchiolitis obliterans syndrome in lung transplant patients. (18551201)
2008
23
Soluble CD30 levels as a diagnostic marker for bronchiolitis obliterans syndrome following human lung transplantation. (18047935)
2008
24
Bronchiolitis obliterans syndrome: alloimmune-dependent and -independent injury with aberrant tissue remodeling. (18707652)
2008
25
Bronchiolitis obliterans syndrome and survival following lung transplantation for patients with sarcoidosis. (19382530)
2008
26
Lung transplantation in the Fischer 344-->Wistar Kyoto rat strain combination is not suitable to study bronchiolitis obliterans. (17403482)
2007
27
Living-donor lobar lung transplantation for broncho-bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: does bronchiolitis obliterans recur in transplanted lungs? (18055347)
2007
28
Nasal tolerance with collagen v protein reverts bronchovascular axis remodeling in experimental bronchiolitis obliterans. (17823714)
2007
29
Improvement of pulmonary function with imatinib mesylate in bronchiolitis obliterans following allogeneic hematopoietic cell transplantation. (16785069)
2006
30
Comparison of mycophenolate mofetil and azathioprine for prevention of bronchiolitis obliterans syndrome in de novo lung transplant recipients. (16612275)
2006
31
Lower incidence of Bronchiolitis obliterans in allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning compared with myeloablative conditioning. (15852024)
2005
32
Bronchiolitis obliterans organising pneumonia: a treatable condition. (16114165)
2005
33
Is it bronchiolitis obliterans syndrome or is it chronic rejection: a reappraisal? (15684284)
2005
34
The incidence and clinical characteristics of bronchiolitis obliterans organizing pneumonia syndrome after radiation therapy for breast cancer. (15554078)
2004
35
Solitary nodular form of bronchiolitis obliterans organizing pneumonia. (15589500)
2004
36
A case of bronchiolitis obliterans organizing pneumonia syndrome with preceding radiation pneumonitis after breast-conserving therapy. (15640508)
2004
37
Bronchiolitis obliterans organizing pneumonia associated with sulfasalazine in a patient with rheumatoid arthritis. (15168156)
2004
38
A case of loxoprofen sodium-induced bronchiolitis obliterans organizing pneumonia (BOOP)]. (14727549)
2003
39
Increased exhaled nitric oxide in bronchiolitis obliterans organizing pneumonia after allogeneic bone marrow transplantation. (12451281)
2002
40
Bronchiolitis obliterans organizing pneumonia associated with Evans syndrome. (11786723)
2001
41
Bilateral symmetrical upper-lobe opacities: an unusual presentation of bronchiolitis obliterans organizing pneumonia. (10988217)
2000
42
Bronchiolitis obliterans organizing pneumonia. Trying to answer an intriguing question. (11185490)
2000
43
Intraluminal fibromyxoid lesions in bronchiolitis obliterans organizing pneumonia are highly capillarized. (10534166)
1999
44
Platelet-derived growth factor in bronchiolitis obliterans-organizing pneumonia. (9032212)
1997
45
Bronchiolitis obliterans organizing pneumonia associated with systemic lupus erythematosus with antiphospholipid antibody. (8739795)
1996
46
Bronchiolitis obliterans in a patient with localized scleroderma treated with D-penicillamine. (8804954)
1996
47
Chronic eosinophilic pneumonia and idiopathic bronchiolitis obliterans organizing pneumonia: comparison of eosinophil number and degranulation by immunofluorescence staining for eosinophil-derived major basic protein. (7531262)
1995
48
Bronchiolitis obliterans organizing pneumonia associated with massive L-tryptophan ingestion. (8252993)
1993
49
Bronchiolitis obliterans-organizing pneumonia (BOOP) in children with malignant disease. (1523049)
1992
50
Radiographic manifestations of bronchiolitis obliterans with organizing pneumonia vs usual interstitial pneumonia. (3490161)
1986

Variations for Bronchiolitis Obliterans

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Expression for genes affiliated with Bronchiolitis Obliterans

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bronchiolitis Obliterans

Search GEO for disease gene expression data for Bronchiolitis Obliterans.

Pathways for genes affiliated with Bronchiolitis Obliterans

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Sources:
51PathCards, 13EMD Millipore, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG, 55R&D Systems
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Pathways related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MMP8, SCGB1A1
2
Show member pathways
9.5IL8, IL17A
39.2IFNA2, CXCL10
49.1MAPKAP1, CXCR3, CXCL10
59.0IL8, IFNA2
6
Show member pathways
9.0CXCL10, CXCR3, IL8
7
Show member pathways
9.0CXCL10, CXCR3, IL8
8
Show member pathways
8.6MMP8, CXCL10, CXCR3, IL8
9
Show member pathways
8.6IL8, IFNA2, CXCL10
10
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.6IL8, IFNA2, CXCL10
11
Show member pathways
8.6IL8, IFNA2, CXCL10
12
Show member pathways
8.5CXCL10, CXCR3, IL8, PDGFB
13
Show member pathways
8.5CXCL10, CXCR3, IL8, PDGFB
14
Show member pathways
8.5CXCL10, CXCR3, IL8, PDGFB
15
Show member pathways
7.9CXCL10, CXCR3, IL8, MAPKAP1, PDGFB
16
Show member pathways
7.3PDGFB, CXCL10, CXCR3, IFNA2, IL17A, IL8

Compounds for genes affiliated with Bronchiolitis Obliterans

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Sources:
46Novoseek, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB, 12DrugBank, 3BitterDB, 25HMDB
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Compounds related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1p002469.8IL17A, MMP8, SCGB1A1
2mcp 1469.8CXCR3, IL8
3flagellin46 3010.8IL8, CXCR3
4polycarbonate469.7IL8, CXCL10
5ns 39846 6210.7IL17A, IL8
6fluticasone propionate46 52 62 1212.7CXCL10, IL8
7ccl446 3010.6CXCL10, CXCR3, IL17A
8allergens469.6CXCR3, CXCL10
9polyinosinic-polycytidylic acid469.5CXCL10, IL8
10poly(i-c)469.5IL8, CXCL10
11doxycycline46 1210.5MMP8, SCGB1A1
12methacholine46 52 1211.5IL8, IL17A
13il 10469.4IL8, CXCR3, CXCL10
14tarc469.4IL8, CXCR3, CXCL10
15ccl346 3010.4IL8, CXCR3, CXCL10
162,5-oligoadenylate469.4CXCL10, IFNA2
17hydrocortisone46 3 62 1212.3IL8, CXCR3, CXCL10
18imiquimod46 62 30 1212.3IFNA2, IL8
19matrigel469.3IL8, CXCR3, CXCL10
20ly294002469.3IL8, IL17A, CXCR3
21creatinine469.3SCGB1A1, CXCL10, CXCR3, IL17A
22phosphatidylinositol469.2SCGB1A1, CXCL10, CXCR3, IL17A
23ribavirin46 52 1211.2CXCL10, CXCR3, IFNA2
24tacrolimus46 52 1211.1PDGFB, IL17A, CXCR3, CXCL10
25genistein46 30 62 3 25 1214.1MMP8, CXCL10, IL8
26groalpha469.1IL8, IL17A, CXCR3, CXCL10
27cyclosporin a46 30 6211.0MMP8, IL17A, IL8, PDGFB
28neopterin469.0CXCL10, IFNA2, IL8
29erythromycin46 3 52 1211.9IL8, IFNA2
30pd 98,059468.9PDGFB, IL8, IL17A, CXCR3
31steroid468.9SCGB1A1, CXCR3, IFNA2, IL17A
32infliximab46 52 1210.9CXCL10, CXCR3, IFNA2, IL17A
33ifn-alpha468.8CXCL10, CXCR3, IFNA2, IL17A
34alanine468.8IFNA2, CXCL10, MMP8, SCGB1A1
35endotoxin468.7SCGB1A1, CXCL10, CXCR3, IL17A, IL8
36pge2468.7MMP8, CXCL10, CXCR3, IL17A, IL8
37etanercept46 52 1210.7IL8, IL17A, IFNA2, CXCR3
38superoxide46 259.6MMP8, CXCR3, IFNA2, IL8
39glucose468.6PDGFB, IFNA2, CXCL10, MMP8
40histamine46 30 2510.6IL8, IFNA2, CXCR3, CXCL10
41rantes468.5CXCL10, CXCR3, IL17A, IL8, MAPKAP1
42dexamethasone46 52 30 1211.5CXCL10, CXCR3, IL17A, IL8, PDGFB
43thymidine46 259.3CXCL10, CXCR3, IFNA2, IL17A, PDGFB
44tyrosine468.2CXCL10, CXCR3, IFNA2, IL17A, PDGFB
45lipid468.0SCGB1A1, MMP8, CXCL10, IFNA2, IL17A, PDGFB
46progesterone46 30 62 25 1212.0SCGB1A1, MMP8, CXCL10, CXCR3, IFNA2, PDGFB
47estrogen468.0SCGB1A1, CXCL10, CXCR3, IFNA2, IL17A, PDGFB
48nitric oxide46 25 129.9SCGB1A1, MMP8, CXCL10, CXCR3, IL17A, IL8
49oxygen46 258.9SCGB1A1, MMP8, CXCR3, IFNA2, IL8, PDGFB
50vegf467.4PDGFB, MMP8, CXCL10, CXCR3, IFNA2, IL17A

GO Terms for genes affiliated with Bronchiolitis Obliterans

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17Gene Ontology
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Cellular components related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2IL17A, CXCR3, CXCL10
2extracellular regionGO:0055767.4MMP8, CXCL10, IFNA2, IL8, PDGFB
3extracellular spaceGO:0056156.9PDGFB, IL8, IL17A, IFNA2, CXCL10, MMP8

Biological processes related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:0308169.9CXCL10, CXCR3
2T cell chemotaxisGO:0108189.9CXCR3, CXCL10
3positive regulation of cAMP-mediated signalingGO:0439509.8CXCR3, CXCL10
4positive regulation of release of sequestered calcium ion into cytosolGO:0512819.8CXCL10, CXCR3
5positive regulation of chemotaxisGO:0509219.8PDGFB, CXCR3
6cellular response to interleukin-1GO:0713479.6IL17A, IL8
7calcium-mediated signalingGO:0197229.4CXCR3, IL8
8negative regulation of angiogenesisGO:0165259.3CXCR3, CXCL10
9chemotaxisGO:0069359.2CXCL10, CXCR3, IL8
10positive regulation of cell proliferationGO:0082849.1PDGFB, CXCR3, CXCL10
11G-protein coupled receptor signaling pathwayGO:0071869.1IL8, CXCR3, CXCL10
12cell surface receptor signaling pathwayGO:0071669.0IFNA2, CXCR3, CXCL10
13cell-cell signalingGO:0072679.0IL17A, IFNA2, CXCL10
14immune responseGO:0069558.9IL8, IL17A, CXCL10
15inflammatory responseGO:0069548.1IL8, IL17A, IFNA2, CXCR3, CXCL10

Molecular functions related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.4IL8, CXCL10

Products for genes affiliated with Bronchiolitis Obliterans

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  • Antibodies
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Sources for Bronchiolitis Obliterans

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet