MCID: BRN012
MIFTS: 59

Bronchiolitis Obliterans malady

Summaries for Bronchiolitis Obliterans

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Bronchiolitis obliterans is an inflammatory obstruction of the lung's tiniest airways, the bronchioles. the bronchioles may become damaged and inflamed after inhalation of toxic fumes, as a result of respiratory infections, in association with connective tissue disorders, or after bone marrow or heart-lung transplants. this leads to extensive scarring that blocks the airways, leading to a dry cough, shortness of breath, fatigue and wheezing in the absence of a cold or asthma. while there is no way to reverse the disease, treatments are available to stabilize or slow the progression.   another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease. last updated: 10/1/2012

MalaCards: Bronchiolitis Obliterans, also known as bronchiolitis fibrosa obliterans, is related to bronchiolitis and pneumonia. An important gene associated with Bronchiolitis Obliterans is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are Chemokine receptors bind chemokines and CXCR3-mediated signaling events. The compounds endotoxin and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow, and related mouse phenotypes are respiratory system and immune system.

Disease Ontology:8 A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults.

Wikipedia:63 Bronchiolitis obliterans (BO), also called obliterative bronchiolitis (OB) and constrictive... more...

Aliases & Classifications for Bronchiolitis Obliterans

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
See all sources

Aliases & Descriptions:

bronchiolitis obliterans 8 42 10 44 30 60
bronchiolitis fibrosa obliterans 8 60
obliterative bronchiolitis 8 42
bronchiolitis, exudative 60
bronchiolitis exudativa 8


External Ids:

Disease Ontology8 DOID:2799
MeSH34 D001989
SNOMED-CT56 40100001, 31886003
NCIt39 C62580

Related Diseases for Bronchiolitis Obliterans

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Bronchiolitis Obliterans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 237)
idRelated DiseaseScoreTop Affiliating Genes
1bronchiolitis32.3IL8
2pneumonia32.0HMOX1, MMP8, IL17A, IL8, CXCL10, CRP
3bronchiolitis obliterans organizing pneumonia32.0TOMM5
4cryptogenic organizing pneumonia31.0TOMM5
5arthritis30.9IL8, CRP, ALB, MMP8, CXCR3, CXCL10
6rheumatoid arthritis30.9CXCL10, CXCR3, SFTPD, BMP6, CRP, IL8
7systemic lupus erythematosus30.8CRP, IL17A, CXCR3, CXCL10
8cystic fibrosis30.7HMOX1, IL8, SCGB1A1, SFTPD, IL17A, ALB
9leukemia30.7CXCR3, IL17A, HMOX1, IFNA2, SCGB1A1, PDGFB
10ulcerative colitis30.7CRP, IL17A, IL8, CXCL10, CXCR3
11breast cancer30.7ALB, CXCL10, MMP8, SCGB1A1, IL17A, BMP6
12sarcoidosis30.6SFTPD, CXCL10, CXCR3, SCGB1A1, PDGFB
13lung cancer30.6SFTPD, MMP8, PDGFB, SCGB1A1, CHKA, CXCR3
14respiratory failure30.5SFTPD, PIK3C2A
15pulmonary fibrosis30.5IL8, BMP6, SFTPD, HMOX1, PDGFB, CXCR3
16tuberculosis30.5SFTPD, IL17A, CXCR3, ALB, CRP, CXCL10
17dermatomyositis30.4IL17A, SFTPD, PIK3C2A, CHKA
18ischemia30.4PDGFB, HMOX1, IL17A, CHKA, PIK3C2A
19hepatitis30.4ALB, PDGFB, CXCL10, IFNA2
20malaria30.1ALB
21cholangitis30.1ALB
22acquired immunodeficiency syndrome30.1ALB
23aspergillosis30.1SFTPD
24pancreatitis30.1CRP, ALB
25hypertension30.1CRP, ALB
26bronchitis30.1CRP
27herpes simplex30.1CXCL10
28bronchiectasis30.1IL8, MMP8
29influenza30.1CXCL10, SFTPD, CXCR3
30myopathy30.1CRP, PIK3C2A, CHKA
31hepatitis b30.1ALB, IFNA2, CXCL10, IL17A
32interstitial lung disease30.1PDGFB, BMP6, SFTPD, IL8
33cryoglobulinemia30.1IFNA2
34pulmonary sarcoidosis30.1PDGFB, SFTPD, CXCR3
35asthma30.1CXCR3, SFTPD, SCGB1A1, CXCL10, IL8, IL17A
36idiopathic pulmonary fibrosis30.1SFTPD, PDGFB, SCGB1A1, BMP6, CXCR3, CXCL10
37acute leukemia30.1IL17A
38hepatitis c30.1CXCR3, IFNA2, CXCL10
39pemphigus10.7
40graft versus host disease10.6
41lupus erythematosus10.6
42pneumothorax10.5
43eosinophilic pneumonia10.5
44chronic eosinophilic pneumonia10.4
45stevens-johnson syndrome10.3
46aspiration pneumonia10.3
47hodgkin's lymphoma10.3
48scleroderma10.3
49bronchiolitis obliterans with obstructive pulmonary disease10.3
50acute interstitial pneumonia10.3

Graphical network of the top 20 diseases related to Bronchiolitis Obliterans:



Diseases related to bronchiolitis obliterans

Clinical Features for Bronchiolitis Obliterans

About this section

Drugs & Therapeutics for Bronchiolitis Obliterans

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bronchiolitis Obliterans

Drug clinical trials:

Search ClinicalTrials for Bronchiolitis Obliterans

Search NIH Clinical Center for Bronchiolitis Obliterans

Search CenterWatch for Bronchiolitis Obliterans

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bronchiolitis Obliterans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchiolitis Obliterans:
Mesenchymal stem cells for obliterative bronchiolitis
Embryonic/Adult Cultured Cells Related to Bronchiolitis Obliterans:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Bronchiolitis Obliterans

About this section

Anatomical Context for Bronchiolitis Obliterans

About this section
Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Bronchiolitis Obliterans:

32
Lung, Bone, Bone marrow, Heart, Breast, T cells, Liver, Colon, B cells, Testes, Kidney, Thyroid, Smooth muscle, Thymus, Trachea

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bronchiolitis Obliterans:
id TissueAnatomical CompartmentCell Relevance
1 LungRespiratory BronchiolesCilliated Cells Potential therapeutic candidate, affected by disease

Animal Models for Bronchiolitis Obliterans or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Bronchiolitis Obliterans:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.3CXCR3, TOMM5, SCGB1A1, SFTPD
2MP:000538710.0HMOX1, SFTPD, PDGFB, SCGB1A1, PIK3C2A, CRP
3MP:000536710.0PDGFB, SCGB1A1, PIK3C2A, IL17A, HMOX1
4MP:00107689.9TOMM5, PIK3C2A, SCGB1A1, PDGFB, SFTPD, CHKA
5MP:00053769.9SFTPD, PDGFB, SCGB1A1, PIK3C2A, CRP, CHKA

Publications for Bronchiolitis Obliterans

About this section
Sources:
50PubMed
See all sources

Articles related to Bronchiolitis Obliterans:

(show top 50)    (show all 697)
idTitleAuthorsYear
1
Redo living-donor lobar lung transplantation for bronchiolitis obliterans associated with antibody-mediated rejection. (24164400)
2014
2
Bronchiolitis Obliterans Associated with Stevens-Johnson Syndrome and Response to Azathioprine. (24014187)
2013
3
YKL-40 and matrix metalloproteinases as potential biomarkers of inflammation and fibrosis in the development of bronchiolitis obliterans syndrome. (24003532)
2013
4
Prognostic value of clinical, morphologic, and immunohistochemical factors in patients with bronchiolitis obliterans-organizing pneumonia. (23114922)
2013
5
Early plasma soluble receptor for advanced glycation end-product levels are associated with bronchiolitis obliterans syndrome. (23331756)
2013
6
Epithelial clara cell injury occurs in bronchiolitis obliterans syndrome after human lung transplantation. (22883104)
2012
7
Post-measles bronchiolitis obliterans in a 3-y-old girl. (22012141)
2012
8
Genetic polymorphisms and bronchiolitis obliterans syndrome after lung transplantation: promising results and recommendations for the future. (22138817)
2012
9
What we know and mostly do not know about bronchiolitis obliterans syndrome. (22233966)
2012
10
Circulating fibrocytes correlate with bronchiolitis obliterans syndrome development after lung transplantation: a novel clinical biomarker. (21801908)
2011
11
Fatal bronchiolitis obliterans complicating Stevens-Johnson syndrome following treatment with nimesulide: a case report. (21781423)
2011
12
Organizing pneumonia and non-necrotizing granulomata on transbronchial biopsy: coexistence or bronchiolitis obliterans organizing pneumonia secondary to Mycobacterium kansasii disease. (21682987)
2011
13
Postinfectious bronchiolitis obliterans in children: clinical and pulmonary function findings. (20717912)
2010
14
Pulmonary function in children and adolescents with postinfectious bronchiolitis obliterans. (20835592)
2010
15
The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation. (19299743)
2009
16
Gastroesophageal reflux in bronchiolitis obliterans syndrome: a new perspective. (19716037)
2009
17
Bronchiolitis obliterans syndrome and survival following lung transplantation for patients with sarcoidosis. (19382530)
2008
18
Severe and recurrent episodes of bronchiolitis obliterans organising pneumonia associated with indolent CD4+ CD8+ T-cell leukaemia. (18515560)
2008
19
Pseudomonas aeruginosa colonization of the allograft after lung transplantation and the risk of bronchiolitis obliterans syndrome. (18337673)
2008
20
Pulmonary hypertension in patients with bronchiolitis obliterans syndrome listed for retransplantation. (18510629)
2008
21
Lung transplantation in the Fischer 344-->Wistar Kyoto rat strain combination is not suitable to study bronchiolitis obliterans. (17403482)
2007
22
Bronchiolitis obliterans organizing pneumonia (BOOP) after thoracic radiotherapy for breast carcinoma. (17201913)
2007
23
Bronchiolitis obliterans organizing pneumonia: experience at three hospitals in Riyadh. (17277498)
2007
24
Improvement of pulmonary function with imatinib mesylate in bronchiolitis obliterans following allogeneic hematopoietic cell transplantation. (16785069)
2006
25
Comparison of mycophenolate mofetil and azathioprine for prevention of bronchiolitis obliterans syndrome in de novo lung transplant recipients. (16612275)
2006
26
Postinfectious bronchiolitis obliterans accompanied by pulmonary hemosiderosis in childhood. (17435911)
2006
27
Radiographic appearance of bronchiolitis obliterans organizing pneumonia (BOOP) developing during Bucillamine treatment for rheumatoid arthritis. (16845241)
2006
28
Immune cell infiltration and broncovascular remodeling after nitric acid nasal instillation in a mouse bronchiolitis obliterans model. (17006750)
2006
29
Bronchiolitis obliterans organizing pneumonia. Clinical and roentgenological features in 26 cases. (15942294)
2005
30
High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children. (15908967)
2005
31
Unusual complication after radiotherapy for breast cancer bronchiolitis obliterans organizing pneumonia case report and review of the literature. (16459640)
2005
32
Bronchiolitis obliterans organizing pneumonia in a patient with non-Hodgkin's lymphoma following R-CHOP and pegylated filgrastim. (16194900)
2005
33
Accuracy of exhaled nitric oxide measurements for the diagnosis of bronchiolitis obliterans syndrome after lung transplantation. (15371677)
2004
34
Another face of bronchiolitis obliterans organizing pneumonia. (12945005)
2003
35
Bronchiolitis obliterans in chronic graft-versus-host disease: analysis of risk factors and treatment outcomes. (14569562)
2003
36
Paraneoplastic pemphigus with bronchiolitis obliterans in a child. (12787274)
2003
37
Interleukin-1 receptor antagonist as a biomarker for bronchiolitis obliterans syndrome in lung transplant recipients. (11889437)
2002
38
Bronchiolitis obliterans organizing pneumonia: clinicopathologic review of a series of 45 Korean patients including rapidly progressive form. (11961300)
2002
39
Bronchiolitis obliterans organizing pneumonia (BOOP) in a case of smouldering adult T-cell leukaemia. (10728737)
2000
40
Slow-resolving pneumonia secondary to bronchiolitis obliterans organizing pneumonia. (10408825)
1999
41
Bronchiolitis obliterans organizing pneumonia associated with systemic lupus erythematosus with antiphospholipid antibody. (8739795)
1996
42
Bronchiolitis obliterans organizing pneumonia (BOOP) in lung transplant recipients. (8915212)
1996
43
Distribution pattern of computed tomography findings in patients with bronchiolitis obliterans organizing pneumonia. (8724121)
1996
44
Percutaneous lung biopsy in the diagnosis of bronchiolitis obliterans organizing pneumonia. (8131589)
1994
45
Low-dose/long-term erythromycin for treatment of bronchiolitis obliterans organizing pneumonia (BOOP). (8231065)
1993
46
A case of bronchiolitis obliterans organizing pneumonia associated with primary SjAPgren's syndrome who died of superimposed diffuse alveolar damage. (1620982)
1992
47
Bronchiolitis obliterans organizing pneumonia. (2595042)
1989
48
Bronchiolitis obliterans organizing pneumonia. (3386221)
1988
49
A comparison of bronchiolitis obliterans with organizing pneumonia, usual interstitial pneumonia, and small airways disease. (3826896)
1987
50
Experimental aspiration pneumonia. V. Acute pulmonary edema, pneumonia, and bronchiolitis obliterans produced by injection of ethyl alcohol. (13410859)
1957

Genetic Variations for Bronchiolitis Obliterans

About this section

Expression for genes affiliated with Bronchiolitis Obliterans

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bronchiolitis Obliterans

Search GEO for disease gene expression data for Bronchiolitis Obliterans.

Pathways for genes affiliated with Bronchiolitis Obliterans

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore
See all sources

Compounds for genes affiliated with Bronchiolitis Obliterans

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.9SCGB1A1, CXCR3
2alpha tocopherol4410.8IFNA2, CHKA
3groalpha4410.7CXCL10, IL8, CXCR3, IL17A
4etanercept44 49 1112.7IL17A, CRP, CXCR3, IFNA2, IL8
5prednisolone44 28 1112.7IFNA2, SFTPD, CRP, PIK3C2A
6dexamethasone44 49 28 1113.7SFTPD, CHKA, BMP6, PDGFB
7rantes4410.7IL17A, MAPKAP1, BMP6, CXCR3
8infliximab44 49 1112.7IFNA2, CXCR3, CRP, IL17A, CXCL10
9glucose4410.7IFNA2, PIK3C2A, SFTPD, MMP8
10cyclosporin a44 28 5912.7HMOX1, IL17A, MMP8, PIK3C2A, PDGFB
11gamma globulin4410.7ALB, CRP, IFNA2
12oxygen44 2411.6PIK3C2A, SFTPD, SCGB1A1, IL8, MMP8, HMOX1
13vitamin a44 11 2412.6IFNA2, CHKA
14il 104410.6IL8, BMP6, CXCL10, CXCR3
15indomethacin44 59 28 1113.6HMOX1
16ifn-alpha4410.6IL17A, CXCR3, CXCL10, IFNA2
17superoxide44 2411.6CXCR3, CHKA, HMOX1, IFNA2, MMP8
18polyethylene glycol4410.6ALB, HMOX1, CRP, BMP6, IFNA2
19tacrolimus44 49 1112.6PDGFB, BMP6, CXCR3, CXCL10, IL17A, ALB
20neopterin4410.6IL8, CRP, CXCL10, IFNA2
21uric acid44 2411.6PIK3C2A, CHKA
22simvastatin44 49 59 28 11 2415.6BMP6, IL8, CHKA, CRP, PIK3C2A, HMOX1
23atorvastatin44 49 28 11 2414.6CHKA, CRP, PIK3C2A, HMOX1, BMP6
24aspartate4410.6SCGB1A1, ALB, CHKA, PIK3C2A, BMP6
25citrate4410.6ALB, PIK3C2A, CRP, CHKA, HMOX1
26ly2940024410.6BMP6, PIK3C2A, CXCR3, HMOX1, IL8, IL17A
27iron44 2411.6PIK3C2A, SCGB1A1, IFNA2, HMOX1
28histamine44 28 2412.6ALB, CXCL10, IL8, CXCR3, BMP6, IFNA2
29prostacyclin4410.5CRP, PDGFB, HMOX1, PIK3C2A, BMP6
30ascorbic acid44 2411.5CHKA, CRP, PIK3C2A, IFNA2, HMOX1, ALB
31thymidine44 2411.5CXCL10, BMP6, SFTPD, IFNA2, PDGFB, IL17A
32cycloheximide4410.5CXCL10, PDGFB
33progesterone44 59 28 11 2414.5MMP8, CXCL10, IFNA2, CXCR3, CHKA, PIK3C2A
34creatinine4410.5ALB, SCGB1A1, CRP, CHKA, CXCR3, CXCL10
35nitric oxide44 11 2412.5HMOX1, MMP8, IL17A, IL8, CXCR3, BMP6
36lactate4410.5PIK3C2A, ALB, SFTPD, BMP6, CRP, CHKA
37imiquimod44 28 59 1113.5IFNA2, IL8, BMP6
38methotrexate44 49 1112.5PIK3C2A, CRP, IL17A, ALB, BMP6
39phosphatidylinositol4410.5CXCR3, SFTPD, PIK3C2A, BMP6, CHKA, CXCL10
40alanine4410.4ALB, HMOX1, MMP8, CXCL10, CHKA, CRP
41vegf4410.4IL17A, CXCL10, CXCR3, CRP, PIK3C2A, BMP6
42steroid4410.4CXCR3, CHKA, PIK3C2A, IFNA2, SCGB1A1, IL17A
43cholesterol44 28 11 2413.4PIK3C2A, CRP, CHKA, CXCR3, CXCL10, ALB
44sb 20358044 5911.4HMOX1, IL17A, CRP, IL8, BMP6
45lipid4410.4MMP8, SFTPD, IFNA2, PDGFB, SCGB1A1, PIK3C2A
46sodium nitroprusside4410.3HMOX1, CXCR3, PIK3C2A, BMP6
47hydrocortisone44 2 59 1113.3IL8
48p0024410.3SCGB1A1, IL17A, CRP, MMP8
49acetylcholine44 49 28 11 2414.3CHKA, HMOX1, BMP6
50isoflurane44 1111.0PIK3C2A, ALB, HMOX1

GO Terms for genes affiliated with Bronchiolitis Obliterans

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1IFNA2, PDGFB, CRP, CXCL10, IL8, MMP8
2extracellular spaceGO:0056159.7ALB, SFTPD, IFNA2, PDGFB, SCGB1A1, BMP6

Biological processes related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.2KIR2DS5, MAPKAP1, PDGFB, IFNA2, SFTPD
2inflammatory responseGO:00695410.1IL17A, IL8, CXCL10, CXCR3, CRP, BMP6
3immune responseGO:0069559.9BMP6, CXCL10, IL8, IL17A, KIR2DS5

Molecular functions related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1choline bindingGO:03326510.4CHKA, CRP

Products for genes affiliated with Bronchiolitis Obliterans

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bronchiolitis Obliterans

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet