MCID: BRN012
MIFTS: 58

Bronchiolitis Obliterans malady

Summaries for Bronchiolitis Obliterans

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Bronchiolitis obliterans is an inflammatory obstruction of the lung's tiniest airways, the bronchioles. the bronchioles may become damaged and inflamed after inhalation of toxic fumes, as a result of respiratory infections, in association with connective tissue disorders, or after bone marrow or heart-lung transplants. this leads to extensive scarring that blocks the airways, leading to a dry cough, shortness of breath, fatigue and wheezing in the absence of a cold or asthma. while there is no way to reverse the disease, treatments are available to stabilize or slow the progression.   another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease. last updated: 10/1/2012

MalaCards: Bronchiolitis Obliterans, also known as bronchiolitis fibrosa obliterans, is related to bronchiolitis and bronchiolitis obliterans organizing pneumonia. An important gene associated with Bronchiolitis Obliterans is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are Chemokine receptors bind chemokines and CXCR3-mediated signaling events. The compounds endotoxin and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lung, and related mouse phenotypes are respiratory system and immune system.

Disease Ontology:8 A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults.

Wikipedia:64 Bronchiolitis obliterans (BO), also called obliterative bronchiolitis (OB) and constrictive... more...

Aliases & Classifications for Bronchiolitis Obliterans

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

bronchiolitis obliterans 8 43 10 45 31 61
bronchiolitis fibrosa obliterans 8 61
obliterative bronchiolitis 8 43
bronchiolitis, exudative 61
bronchiolitis exudativa 8


External Ids:

Disease Ontology8 DOID:2799
MeSH35 D001989
SNOMED-CT57 40100001, 31886003
NCIt40 C62580

Related Diseases for Bronchiolitis Obliterans

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Bronchiolitis Obliterans family:

bronchiolitis obliterans with obstructive pulmonary disease

Diseases related to Bronchiolitis Obliterans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1bronchiolitis32.3IL8
2bronchiolitis obliterans organizing pneumonia32.0TOMM5
3cryptogenic organizing pneumonia31.0TOMM5
4arthritis30.9IL8, CRP, ALB, MMP8, CXCR3, CXCL10
5systemic lupus erythematosus30.8CRP, IL17A, CXCR3, CXCL10
6cystic fibrosis30.8HMOX1, IL8, SCGB1A1, SFTPD, IL17A, ALB
7ulcerative colitis30.7CRP, IL17A, IL8, CXCL10, CXCR3
8polymyositis30.5PIK3C2A, SFTPD, IL17A, CHKA
9tuberculosis30.5SFTPD, IL17A, CXCR3, ALB, CRP, CXCL10
10hepatitis b30.4ALB, IFNA2, CXCL10, IL17A
11asthma30.4CXCR3, SFTPD, SCGB1A1, CXCL10, IL8, IL17A
12hepatitis c30.4CXCR3, IFNA2, CXCL10
13hepatitis e30.2PDGFB
14acquired immunodeficiency syndrome30.2ALB
15pulmonary disease, chronic obstructive30.2CRP, SFTPD
16aspergillosis30.2SFTPD
17bronchitis30.2CRP
18bronchiectasis30.2IL8, MMP8
19cryoglobulinemia30.2IFNA2
20pulmonary sarcoidosis30.2PDGFB, SFTPD, CXCR3
21idiopathic pulmonary fibrosis30.2SFTPD, PDGFB, SCGB1A1, BMP6, CXCR3, CXCL10
22acute leukemia30.2IL17A
23hematopoietic stem cell transplantation10.9
24n syndrome10.8
25pemphigus10.7
26paraneoplastic pemphigus10.7
27graft versus host disease10.6
28chronic graft versus host disease10.6
29usual interstitial pneumonia10.5
30chronic eosinophilic pneumonia10.4
31pulmonary function10.4
32stevens-johnson syndrome10.4
33aspiration pneumonia10.4
34bronchiolitis obliterans with obstructive pulmonary disease10.4
35acute interstitial pneumonia10.3
36lung lymphoma10.3
37juvenile rheumatoid arthritis10.3
38gastroesophageal reflux disease10.3
39measles10.3
40adult syndrome10.3
41hepatitis a10.3
42t-cell leukemia10.3
43char syndrome10.3
44acute graft versus host disease10.3
45spontaneous pneumothorax10.3
46primary pulmonary hypertension10.2
47hyperlucent lung10.2
48diffuse panbronchiolitis10.2
49hypereosinophilic syndrome10.2
50mycobacterium chelonae10.2

Graphical network of the top 20 diseases related to Bronchiolitis Obliterans:



Diseases related to bronchiolitis obliterans

Clinical Features for Bronchiolitis Obliterans

Drugs & Therapeutics for Bronchiolitis Obliterans

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bronchiolitis Obliterans

Drug clinical trials:

Search ClinicalTrials for Bronchiolitis Obliterans

Search NIH Clinical Center for Bronchiolitis Obliterans

Search CenterWatch for Bronchiolitis Obliterans

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bronchiolitis Obliterans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchiolitis Obliterans:
Mesenchymal stem cells for obliterative bronchiolitis
Embryonic/Adult Cultured Cells Related to Bronchiolitis Obliterans:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Bronchiolitis Obliterans

Anatomical Context for Bronchiolitis Obliterans

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Bronchiolitis Obliterans:

33
Liver, Kidney, Lung, Bone marrow, Thymus, Heart, Smooth muscle, Colon, Thyroid, Breast, Placenta, T cells, B lymphoblasts, B cells, Trachea, Bronchial epithelium

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bronchiolitis Obliterans:
id TissueAnatomical CompartmentCell Relevance
1 LungRespiratory BronchiolesCilliated Cells Potential therapeutic candidate, affected by disease

Animal Models for Bronchiolitis Obliterans or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Bronchiolitis Obliterans

Sources:
51PubMed
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Articles related to Bronchiolitis Obliterans:

(show top 50)    (show all 698)
idTitleAuthorsYear
1
Treatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model. (24199758)
2013
2
Exercise capacity in adolescent and adult patients with post infectious bronchiolitis obliterans. (24375976)
2013
3
Reestablishment of recipient-associated microbiota in the lung allograft is linked to reduced risk of bronchiolitis obliterans syndrome. (23328523)
2013
4
Prevention of the second stage of epithelial loss is a potential novel treatment for bronchiolitis obliterans. (22939854)
2013
5
Secondary bronchiolitis obliterans organizing pneumonia during treatment of chronic hepatitis C: role of pegylated interferon alfa-2a. (23152355)
2012
6
Work of breathing to optimize noninvasive ventilation in bronchiolitis obliterans. (22270472)
2012
7
A prospective interventional study on the use of extracorporeal photopheresis in patients with bronchiolitis obliterans syndrome after lung transplantation. (22884382)
2012
8
Exhaled nitric oxide in diagnosis of bronchiolitis obliterans syndrome in lung transplant recipients: possible limitations. (22054303)
2011
9
Incidence, risk factors and outcomes of bronchiolitis obliterans after allogeneic stem cell transplantation. (21424350)
2011
10
Clara cell secretory protein and surfactant protein-D do not predict bronchiolitis obliterans syndrome after lung transplantation. (20683434)
2010
11
Post infectious bronchiolitis obliterans in children. (21109182)
2010
12
Adenosine signaling via the adenosine 2B receptor is involved in bronchiolitis obliterans development. (20920842)
2010
13
Saber-sheath trachea in a patient with bronchiolitis obliterans syndrome after lung transplantation. (19176714)
2009
14
Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. (19602690)
2009
15
Effect of maintenance azithromycin on established bronchiolitis obliterans syndrome in lung transplant patients. (18551201)
2008
16
Soluble CD30 levels as a diagnostic marker for bronchiolitis obliterans syndrome following human lung transplantation. (18047935)
2008
17
The role of the IL23/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation. (18786233)
2008
18
Attenuation of airway obliteration by ciprofloxacin in experimental posttransplant bronchiolitis obliterans. (18337667)
2008
19
Quality of life and bronchiolitis obliterans syndrome in patients after lung transplantation. (17624136)
2007
20
Bronchiolitis obliterans following haematopoietic stem cell transplantation. (17470622)
2007
21
T regulatory cells in stable posttransplant bronchiolitis obliterans syndrome. (17984845)
2007
22
Post-transplant baseline FEV1 and the development of bronchiolitis obliterans syndrome: an important confounder? (18022078)
2007
23
Bronchiolitis obliterans syndrome (BOS), bronchiolitis obliterans organizing pneumonia (BOOP), and other late-onset noninfectious pulmonary complications following allogeneic hematopoietic stem cell transplantation. (17580252)
2007
24
Bronchiolitis obliterans: a rare chronic pulmonary complication associated with Stevens-Johnson syndrome. (17845150)
2007
25
Oleic acid-associated bronchiolitis obliterans-organizing pneumonia in beagle dogs. (16537936)
2006
26
Risk factors for the development of bronchiolitis obliterans in children with bronchiolitis. (16517579)
2006
27
Minimal acute rejection after lung transplantation: a risk for bronchiolitis obliterans syndrome. (15996255)
2005
28
Bronchiolitis obliterans organizing pneumonia as an initial manifestation in systemic lupus erythematosus. (15880402)
2005
29
Nitric acid-induced bronchiolitis in rats mimics childhood Bronchiolitis obliterans. (16106109)
2005
30
Bronchiolitis obliterans with organizing pneumonia in rheumatoid arthritis--a fatal case and short review of literature. (15378265)
2005
31
Simultaneous donor marrow cell transplantation with reduced intensity conditioning prevents tracheal allograft obliteration in a bronchiolitis obliterans murine model. (16354876)
2005
32
Exhaled NO may predict the decline in lung function in bronchiolitis obliterans syndrome. (15863637)
2005
33
The incidence and clinical characteristics of bronchiolitis obliterans organizing pneumonia syndrome after radiation therapy for breast cancer. (15554078)
2004
34
Azithromycin therapy for patients with bronchiolitis obliterans syndrome after lung transplantation. (15167610)
2004
35
An unusual case of bronchiolitis obliterans organizing pneumonia concomitant with bronchioloalveolar carcinoma. (14872120)
2004
36
Post-transplant bronchiolitis obliterans. (14680094)
2003
37
Bronchiolitis obliterans organizing pneumonia in a patient with primary biliary cirrhosis and rheumatoid arthritis treated with prednisolone. (12191678)
2002
38
Bronchiolitis obliterans organizing pneumonia. Trying to answer an intriguing question. (11185490)
2000
39
Bronchiolitis obliterans organizing pneumonia. (16088727)
2000
40
Paraneoplastic pemphigus associated with bronchiolitis obliterans. (10669715)
2000
41
Soluble form of fas and fas ligand in BAL fluid from patients with pulmonary fibrosis and bronchiolitis obliterans organizing pneumonia. (10936140)
2000
42
Intraluminal fibromyxoid lesions in bronchiolitis obliterans organizing pneumonia are highly capillarized. (10534166)
1999
43
Bronchiolitis obliterans organizing pneumonia associated with polymyalgia rheumatica. (10362063)
1999
44
Bronchiolitis obliterans organizing pneumonia as the first manifestation of polymyositis. (9042178)
1997
45
Bronchiolitis obliterans organizing pneumonia-like reactions: a nonspecific response or an atypical form of rejection or infection in lung allograft recipients? (8698317)
1996
46
Cavitary bronchiolitis obliterans organizing pneumonia. (8620945)
1995
47
The association of bronchiolitis obliterans organizing pneumonia, systemic lupus erythematosus, and Hunner's cystitis. (8339671)
1993
48
Bronchiolitis obliterans organizing pneumonia. (1441473)
1992
49
Unilateral bronchiolitis obliterans organizing pneumonia and bronchoalveolar lavage neutrophilia in a patient with parainfluenza 3 virus infection. (1653446)
1991
50
Free-base cocaine use associated with bronchiolitis obliterans organizing pneumonia. (3605899)
1987

Genetic Variations for Bronchiolitis Obliterans

Expression for genes affiliated with Bronchiolitis Obliterans

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bronchiolitis Obliterans

Search GEO for disease gene expression data for Bronchiolitis Obliterans.

Pathways for genes affiliated with Bronchiolitis Obliterans

Sources:
54Reactome, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 12EMD Millipore
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Compounds for genes affiliated with Bronchiolitis Obliterans

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.9CXCR3, SCGB1A1
2alpha tocopherol4510.8CHKA, IFNA2
3groalpha4510.7CXCR3, CXCL10, IL8, IL17A
4etanercept45 50 1112.7IFNA2, CRP, CXCR3, IL8, IL17A
5prednisolone45 29 1112.7SFTPD, IFNA2, PIK3C2A, CRP
6dexamethasone45 50 29 1113.7SFTPD, PDGFB, BMP6, CHKA
7rantes4510.7BMP6, MAPKAP1, CXCR3, IL17A
8infliximab45 50 1112.7IFNA2, CRP, CXCR3, CXCL10, IL17A
9glucose4510.7SFTPD, IFNA2, PIK3C2A, MMP8
10cyclosporin a45 29 6012.7HMOX1, MMP8, IL17A, PIK3C2A, PDGFB
11gamma globulin4510.7ALB, CRP, IFNA2
12oxygen45 2411.6SFTPD, SCGB1A1, PIK3C2A, IL8, MMP8, HMOX1
13vitamin a45 11 2412.6CHKA, IFNA2
14il 104510.6BMP6, CXCR3, CXCL10, IL8
15indomethacin45 60 29 1113.6HMOX1
16ifn-alpha4510.6IL17A, CXCL10, CXCR3, IFNA2
17superoxide45 2411.6HMOX1, MMP8, CXCR3, CHKA, IFNA2
18polyethylene glycol4510.6IFNA2, BMP6, CRP, HMOX1, ALB
19tacrolimus45 50 1112.6PDGFB, BMP6, CXCR3, CXCL10, IL17A, ALB
20neopterin4510.6IFNA2, CRP, CXCL10, IL8
21uric acid45 2411.6CHKA, PIK3C2A
22simvastatin45 50 60 29 11 2415.6BMP6, PIK3C2A, CRP, CHKA, IL8, HMOX1
23atorvastatin45 50 29 11 2414.6BMP6, PIK3C2A, CRP, CHKA, HMOX1
24aspartate4510.6SCGB1A1, BMP6, PIK3C2A, CHKA, ALB
25citrate4510.6ALB, HMOX1, CHKA, CRP, PIK3C2A
26ly2940024510.6BMP6, PIK3C2A, CRP, CXCR3, IL8, IL17A
27iron45 2411.6IFNA2, SCGB1A1, PIK3C2A, HMOX1
28histamine45 29 2412.6SFTPD, IFNA2, BMP6, CXCR3, CXCL10, IL8
29prostacyclin4510.5PDGFB, BMP6, PIK3C2A, CRP, HMOX1
30ascorbic acid45 2411.5IFNA2, PIK3C2A, CRP, CHKA, HMOX1, ALB
31thymidine45 2411.5SFTPD, IFNA2, PDGFB, BMP6, CHKA, CXCR3
32cycloheximide4510.5CXCL10, PDGFB
33progesterone45 60 29 11 2414.5IFNA2, PDGFB, SCGB1A1, BMP6, PIK3C2A, CHKA
34creatinine4510.5SCGB1A1, BMP6, PIK3C2A, CRP, CHKA, CXCR3
35nitric oxide45 11 2412.5SFTPD, PDGFB, SCGB1A1, BMP6, CXCR3, CXCL10
36lactate4510.5SFTPD, BMP6, PIK3C2A, CRP, CHKA, IL8
37imiquimod45 29 60 1113.5IL8, BMP6, IFNA2
38methotrexate45 50 1112.5BMP6, PIK3C2A, CRP, IL17A, ALB
39phosphatidylinositol4510.5SFTPD, SCGB1A1, BMP6, PIK3C2A, CHKA, CXCR3
40alanine4510.4PIK3C2A, BMP6, SCGB1A1, IFNA2, CRP, CHKA
41vegf4510.4IFNA2, PDGFB, BMP6, PIK3C2A, CRP, CXCR3
42steroid4510.4SFTPD, IFNA2, SCGB1A1, PIK3C2A, CHKA, CXCR3
43cholesterol45 29 11 2413.4SFTPD, PIK3C2A, CRP, CHKA, CXCR3, CXCL10
44sb 20358045 6011.4BMP6, CRP, IL8, IL17A, HMOX1
45lipid4510.4SFTPD, IFNA2, PDGFB, SCGB1A1, PIK3C2A, CRP
46sodium nitroprusside4510.3BMP6, PIK3C2A, CXCR3, HMOX1
47hydrocortisone45 2 60 1113.3IL8
48p0024510.3MMP8, IL17A, CRP, SCGB1A1
49acetylcholine45 50 29 11 2414.3HMOX1, CHKA, BMP6
50isoflurane45 1111.0ALB, HMOX1, PIK3C2A

GO Terms for genes affiliated with Bronchiolitis Obliterans

Sources:
16Gene Ontology
See all sources

Cellular components related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1IFNA2, PDGFB, CRP, CXCL10, IL8, MMP8
2extracellular spaceGO:0056159.7ALB, SFTPD, IFNA2, PDGFB, SCGB1A1, BMP6

Biological processes related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.2KIR2DS5, MAPKAP1, PDGFB, IFNA2, SFTPD
2inflammatory responseGO:00695410.1IL17A, IL8, CXCL10, CXCR3, CRP, BMP6
3immune responseGO:0069559.9BMP6, CXCL10, IL8, IL17A, KIR2DS5

Molecular functions related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1choline bindingGO:03326510.4CHKA, CRP

Products for genes affiliated with Bronchiolitis Obliterans

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Sources for Bronchiolitis Obliterans

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet