MCID: BRN012
MIFTS: 58

Bronchiolitis Obliterans malady

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Bronchiolitis Obliterans

Aliases & Descriptions for Bronchiolitis Obliterans:

Name: Bronchiolitis Obliterans 38 12 50 52 42 14 69
Bronchiolitis Fibrosa Obliterans 12 69
Obliterative Bronchiolitis 12 50
Bronchiolitis, Exudative 69
Bronchiolitis Exudativa 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2799
MeSH 42 D001989
NCIt 47 C62580
SNOMED-CT 64 40100001
UMLS 69 C0006272

Summaries for Bronchiolitis Obliterans

NIH Rare Diseases : 50 bronchiolitis obliterans is an inflammatory condition that affects the lung's tiniest airways, the bronchioles. in affected people, the bronchioles may become damaged and inflamed leading to extensive scarring that blocks the airways. signs and symptoms of the condition include a dry cough; shortness of breath; and/or fatigue and wheezing in the absence of a cold or asthma. many different chemicals (such as nitrogen oxides, ammonia, welding fumes or food flavoring fumes) and respiratory infections can cause lung injury that leads to bronchiolitis obliterans. it can also be associated with rheumatoid arthritis and graft-versus-host disease following a lung or hematopoietic cell transplantation. while there is no way to reverse the disease, treatments are available that may stabilize or slow the progression. another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease. last updated: 11/1/2016

MalaCards based summary : Bronchiolitis Obliterans, also known as bronchiolitis fibrosa obliterans, is related to tuberculosis and hepatitis. An important gene associated with Bronchiolitis Obliterans is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Miconazole and Montelukast have been mentioned in the context of this disorder. Affiliated tissues include Lung, lung and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Disease Ontology : 12 A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults.

Wikipedia : 71 Bronchiolitis obliterans (BO), informally known as popcorn lung, is a disease that results in... more...

Related Diseases for Bronchiolitis Obliterans

Diseases related to Bronchiolitis Obliterans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 346)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 30.0 IL10 IL17A IL6 TNF
2 hepatitis 29.9 IFNG IL10 IL6 TNF
3 cryptococcosis 29.9 IL10 IL17A TNF
4 diffuse large b-cell lymphoma 29.8 MMP9 PDGFB TGFB1
5 rheumatoid arthritis 29.7 CXCL8 IFNG IL10 IL17A IL6 TGFB1
6 pulmonary tuberculosis 29.6 CXCL8 IFNG IL10 IL6 TNF
7 bronchiolitis obliterans with obstructive pulmonary disease 12.1
8 cryptogenic organizing pneumonia 12.1
9 bronchiolitis 11.2
10 pneumonia 11.0
11 hematopoietic stem cell transplantation 10.6
12 pemphigus 10.4
13 paraneoplastic pemphigus 10.4
14 hypersensitivity reaction type iii disease 10.3 CXCL8 MMP9
15 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
16 refractory celiac disease 10.3 IL10 TGFB1
17 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 TNF
18 amyotrophic lateral sclerosis type 14 10.3 CXCL8 IFNG TNF
19 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
20 urethral intrinsic sphincter deficiency 10.3 IFNG MMP9 TNF
21 histiocytoma 10.3 CXCL8 MMP9 TNF
22 distal trisomy 14q 10.3 IFNG TGFB1 TNF
23 aniseikonia 10.2 IFNG IL17A TNF
24 hyperimmunoglobulin syndrome 10.2 CXCL8 IFNG TNF
25 tracheitis 10.2 CXCL8 IFNG TNF
26 conidiobolomycosis 10.2 CXCL8 IL10 TNF
27 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IFNG IL10 TNF
28 arthritis 10.2
29 asymptomatic neurosyphilis 10.2 IFNG IL10
30 thymic neuroendocrine carcinoma 10.2 CXCL8 IL6 TNF
31 neurotic disorder 10.2 IFNG IL10 TNF
32 pulpitis 10.2 IFNG IL10 TNF
33 tularemia 10.2 IFNG IL10 TNF
34 immunodeficiency due to a late component of complement deficiency 10.2 CXCL8 IFNG IL10
35 cicatricial lagophthalmos 10.2 CXCL8 IL6 TNF
36 acquired thrombocytopenia 10.2 CXCL8 IL6 TNF
37 rickettsialpox 10.2 IFNG IL10 TNF
38 microcephaly 10.2 IFNG IL10 TNF
39 clostridium difficile colitis 10.2 IFNG IL6 TNF
40 childhood central nervous system mixed germ cell tumor 10.2 CXCL8 IL10 TNF
41 orthostatic proteinuria 10.2 CXCL8 IL6 TNF
42 oculomotor nerve paralysis 10.2 CXCL8 IL6
43 abnormal retinal correspondence 10.2 IFNG IL10 TNF
44 neuropathy 10.2 CXCL8 IL6 TNF
45 discharging ear 10.2 IFNG IL10 TGFB1
46 aminoaciduria 10.2 MMP8 MMP9
47 systemic lupus erythematosus 10.2
48 chronic graft versus host disease 10.2
49 lupus erythematosus 10.2
50 acquired polycythemia 10.2 CXCL8 IL10 TNF

Graphical network of the top 20 diseases related to Bronchiolitis Obliterans:



Diseases related to Bronchiolitis Obliterans

Symptoms & Phenotypes for Bronchiolitis Obliterans

GenomeRNAi Phenotypes related to Bronchiolitis Obliterans according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CXCL8 GZMB IL10 IL17A TGFB1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CXCL8 GZMB IL10 IL17A TGFB1 TNF

MGI Mouse Phenotypes related to Bronchiolitis Obliterans:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 CXCR3 IFNG IL10 IL17A IL6 MMP7
2 immune system MP:0005387 10.29 MMP8 MMP9 PDGFB SCGB1A1 TGFB1 TIMP1
3 cardiovascular system MP:0005385 10.26 CXCR3 IFNG IL10 IL6 MMP7 MMP9
4 growth/size/body region MP:0005378 10.26 IFNG IL10 IL17A IL6 MMP7 MMP9
5 hematopoietic system MP:0005397 10.25 CXCR3 IFNG IL10 IL17A IL6 MMP7
6 mortality/aging MP:0010768 10.21 MMP9 PDGFB SCGB1A1 TGFB1 TIMP1 TNF
7 digestive/alimentary MP:0005381 10.15 IFNG IL10 IL17A IL6 MMP7 MMP9
8 endocrine/exocrine gland MP:0005379 10.14 IFNG IL10 IL17A IL6 SCGB1A1 TGFB1
9 neoplasm MP:0002006 10.11 CXCR3 IFNG IL10 IL6 MMP7 MMP8
10 integument MP:0010771 10 IL10 IL6 MMP9 PDGFB TGFB1 TNF
11 muscle MP:0005369 9.95 MMP9 PDGFB TGFB1 TNF IFNG IL10
12 renal/urinary system MP:0005367 9.92 IL6 MMP9 PDGFB SCGB1A1 TGFB1 CXCR3
13 respiratory system MP:0005388 9.9 CXCR3 IFNG IL10 IL17A IL6 MMP9
14 reproductive system MP:0005389 9.86 IFNG IL10 IL6 MMP9 PDGFB TGFB1
15 skeleton MP:0005390 9.56 IFNG IL10 IL17A IL6 MMP9 TGFB1
16 vision/eye MP:0005391 9.23 IFNG IL10 IL6 MMP7 MMP9 PDGFB

Drugs & Therapeutics for Bronchiolitis Obliterans

Drugs for Bronchiolitis Obliterans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 117)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
2
Montelukast Approved Phase 4,Phase 2 158966-92-8 5281040
3
Azithromycin Approved Phase 4,Phase 3,Phase 2,Phase 1 83905-01-5 55185 53477736 447043
4
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
5
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
6
Mechlorethamine Approved Phase 4,Phase 3 51-75-2 4033
7
Azathioprine Approved Phase 4 446-86-6 2265
8
Everolimus Approved Phase 4,Phase 3 159351-69-6 6442177
9
Prednisone Approved, Vet_approved Phase 4,Phase 1,Phase 2 53-03-2 5865
10
Sirolimus Approved, Investigational Phase 4,Phase 3 53123-88-9 5284616 6436030 46835353
11
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 104987-11-3 445643 439492
12
Macitentan Approved Phase 4 441798-33-0
13
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
14 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
15 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
16 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
18 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 Bone Density Conservation Agents Phase 4
20 Ergocalciferols Phase 4
21 Micronutrients Phase 4
22 Trace Elements Phase 4
23 vitamin d Phase 4
24 Vitamins Phase 4
25 Anti-Asthmatic Agents Phase 4,Phase 2
26 Cysteinyl-leukotriene Phase 4
27 Hormone Antagonists Phase 4,Phase 2,Phase 1
28 Hormones Phase 4,Phase 2,Phase 1
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1
30 Leukotriene Antagonists Phase 4,Phase 2
31 Respiratory System Agents Phase 4,Phase 2
32 Adrenergic Agents Phase 4,Phase 2
33 Adrenergic Agonists Phase 4,Phase 2
34 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 2
35 Adrenergic beta-Agonists Phase 4,Phase 2
36 Albuterol Phase 4
37 Autonomic Agents Phase 4,Phase 2
38 Bromides Phase 4
39 Bronchodilator Agents Phase 4,Phase 2
40 Cholinergic Agents Phase 4
41 Cholinergic Antagonists Phase 4
42 Neurotransmitter Agents Phase 4,Phase 2
43 Parasympatholytics Phase 4
44 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
45 Tiotropium Bromide Phase 4 136310-93-5
46 Tocolytic Agents Phase 4
47 Anti-Bacterial Agents Phase 4,Phase 3
48 Erythromycin Estolate Phase 4
49 Erythromycin Ethylsuccinate Phase 4
50 Erythromycin stearate Phase 4

Interventional clinical trials:

(show top 50) (show all 91)
id Name Status NCT ID Phase
1 Vitamin D in Bronchiolitis Obliterans Syndrome Completed NCT01212406 Phase 4
2 Montelukast in Bronchiolitis Obliterans Syndrome Completed NCT01211509 Phase 4
3 Bronchodilator Responsiveness in Obliterative Bronchiolitis Completed NCT01112241 Phase 4
4 Azithromycin in Bronchiolitis Obliterans Syndrome Completed NCT01009619 Phase 4
5 Safety Study of Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS) Completed NCT01469364 Phase 4
6 Use of Erythromycin in Mustard-Induced Bronchiolitis Completed NCT00367419 Phase 4
7 Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation Completed NCT01109160 Phase 4
8 Comparison of Sirolimus and Azathioprine in Lung Transplantation Completed NCT00321906 Phase 4
9 Macitentan in the Treatment of Organ Rejection After Lung Transplantation Not yet recruiting NCT02893176 Phase 4
10 Tacrolimus Versus Cyclosporine for Immunosuppression After Lung Transplantation Completed NCT01429844 Phase 3
11 Study of Cyclosporine Inhalation Solution (CIS) in Improving Bronchiolitis Obliterans Syndrome-Free Survival Following Lung Transplantation Completed NCT00755781 Phase 3
12 Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Prevention of Acute Rejection and Bronchiolitis Obliterans in Lung Transplant Completed NCT00188825 Phase 3
13 Use of Clarithromycin in Mustard-Induced Bronchiolitis Completed NCT00381147 Phase 3
14 Immunosuppressive Therapy With Certican (Everolimus) After Lung Transplantation Completed NCT00402532 Phase 3
15 Efficacy of Everolimus in Combination With Specific Standard Immunosuppressive Regimen Lung Transplant Recipients Completed NCT01404325 Phase 3
16 European Trial of Pirfenidone in BOS, A European Multi-center Study Recruiting NCT02262299 Phase 2, Phase 3
17 Bronchopulmonary Function in Response to Azithromycin Treatment for Chronic Lung Disease in HIV-infected Children Recruiting NCT02426112 Phase 3
18 Efficacy of Azithromycin to Prevent Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation Active, not recruiting NCT01959100 Phase 3
19 Long-term Safety Follow-up Study in the Prevention of Bronchiolitis Obliterans Syndrome (BOS) Terminated NCT01439958 Phase 3
20 L-CsA in the Prevention of Bronchiolitis Obliterans Syndrome (BOS) in Lung Transplant (LT) Patients Terminated NCT01334892 Phase 2, Phase 3
21 CIS001 Extension Study of Cyclosporine Inhalation Solution Terminated NCT00938236 Phase 3
22 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3
23 A Phase II Trial on Treatment of Steroid-refractory Bronchiolitis Obliterans With Interferon Gamma 1b After Allogeneic SCT Unknown status NCT01639261 Phase 2
24 Study of Rituximab in Patients With Steroid-Refractory Chronic Graft-Versus-Host Disease Unknown status NCT00472225 Phase 2
25 Targeted Therapy of Bronchiolitis Obliterans Syndrome Completed NCT01307462 Phase 2
26 Inhaled BUDESONIDE/FORMOTEROL in Bronchiolitis Obliterans Following Stem Cell Transplantation Completed NCT01560689 Phase 2
27 Aerosol Liposomal Cyclosporine for Chronic Rejection in Lung Transplant Recipients Completed NCT01650545 Phase 1, Phase 2
28 Prospective Evaluation of the Efficacy of Budesonide/Formoterol in Bronchiolitis Obliterans in AHSCT Completed NCT00624754 Phase 2
29 Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant Completed NCT00141726 Phase 2
30 Etanercept for Non-Infectious Lung Injury Following Bone Marrow Transplantation Completed NCT00029328 Phase 1, Phase 2
31 Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans Recruiting NCT01287078 Phase 2
32 Extension Study (Extended Access) of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans Recruiting NCT01273207 Phase 2
33 AZD9668, an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation Recruiting NCT02669251 Phase 1, Phase 2
34 Prospective Study for Transplant Optimization Using Functional Imaging (TROFI) Recruiting NCT02488304 Phase 2
35 MSC for Treatment of Interstitial Lung Disease After Allo-HSCT Recruiting NCT02543073 Phase 1, Phase 2
36 Macrolide Therapy to Improve Forced Expiratory Volume in 1 Second in Adults With Sickle Cell Disease Recruiting NCT02960503 Phase 1, Phase 2
37 Study to Evaluate the Safety and Efficacy of Intravenous Glassia® Treatment in Lung Transplantation Recruiting NCT02614872 Phase 2
38 Trial of Bone-marrow Derived Mesenchymal Stromal Cells (MSC) for New Onset Chronic Lung Allograft Dysfunction Recruiting NCT02709343 Phase 2
39 Montelukast to Treat Bronchiolitis Obliterans Active, not recruiting NCT00656058 Phase 2
40 A Proposal to Test the Efficacy and Tolerability of Bortezomib in Pulmonary Chronic GVHD Active, not recruiting NCT01163786 Phase 2
41 Steroids, Azithromycin, Montelukast, and Symbicort (SAMS) for Viral Respiratory Tract Infection Post Allotransplant Suspended NCT01432080 Phase 2
42 Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability Suspended NCT01615484 Phase 2
43 A Study to Evaluate the Potential of Mesenchymal Stromal Cells to Treat Obliterative Bronchiolitis After Lung Transplantation Completed NCT01175655 Phase 1
44 Mesenchymal Stem Cell Therapy for Lung Rejection Active, not recruiting NCT02181712 Phase 1
45 Characterization of Bronchiolitis-obliterans Syndrome (BOS) Following Lung Transplantation Unknown status NCT00774449
46 Dry Powder Inhalation of Cyclosporine A in Lung Transplant Patients With Bronchiolitis Obliterans Syndrome Unknown status NCT00378677 Early Phase 1
47 Immune Mechanisms of Rejection in Human Lung Allografts Unknown status NCT00861900
48 Multi Breath Nitrogen Washout (MBNW) as a Measure of Small Airway Function in Patients With Respiratory Disease Unknown status NCT00163696
49 Clinical Status and Bronchial Inflammation in Patients With Bronchiolitis Obliterans Completed NCT01327248
50 Effectiveness of Azithromycin Therapy in Improvement of Symptoms and Lung Function in Patients With Bronchiolitis Obliterans After Bone Marrow Transplantation Completed NCT00563251

Search NIH Clinical Center for Bronchiolitis Obliterans

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bronchiolitis Obliterans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchiolitis Obliterans:
Mesenchymal stem cells for obliterative bronchiolitis
Embryonic/Adult Cultured Cells Related to Bronchiolitis Obliterans:
Bone marrow-derived mesenchymal stem cells (family)

Cochrane evidence based reviews: bronchiolitis obliterans

Genetic Tests for Bronchiolitis Obliterans

Anatomical Context for Bronchiolitis Obliterans

MalaCards organs/tissues related to Bronchiolitis Obliterans:

39
Lung, Bone, Breast, Bone Marrow, T Cells, Liver, Colon
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Bronchiolitis Obliterans:
id Tissue Anatomical CompartmentCell Relevance
1 Lung Respiratory Bronchioles Cilliated Cells Potential therapeutic candidate, affected by disease

Publications for Bronchiolitis Obliterans

Articles related to Bronchiolitis Obliterans:

(show top 50) (show all 811)
id Title Authors Year
1
Respiratory reactance in children aged three to fiveA years with postinfectious bronchiolitis obliterans is higher than in those with asthma. ( 27743492 )
2017
2
Bronchiolitis obliterans syndrome in adults after allogeneic stem cell transplantation-pathophysiology, diagnostics and treatment. ( 28052713 )
2017
3
An autopsy case of bronchiolitis obliterans as a previously unrecognized adverse event of afatinib treatment. ( 28012496 )
2017
4
Prevention of bronchiolitis obliterans-the realization of a hope? ( 27667135 )
2016
5
Short-Term Variation of Lung Function and Airway Inflammation in Children and Adolescents with Bronchiolitis Obliterans. ( 27325047 )
2016
6
Phenytoin induced Steven-Johnson syndrome and bronchiolitis obliterans - case report and review of literature. ( 27222786 )
2016
7
Bronchiolitis obliterans organising pneumonia associated with anticonvulsant hypersensitivity syndrome induced by lamotrigine. ( 26825933 )
2016
8
Lung Function Trajectory in Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplantation. ( 27513368 )
2016
9
Early outcomes of lung transplantation for bronchiolitis obliterans syndrome after allogeneic haematopoietic stem cell transplantation: a single-centre experience. ( 27481680 )
2016
10
The Impact of Alemtuzumab and Basiliximab Induction on Patient Survival and Time to Bronchiolitis Obliterans Syndrome in Double Lung Transplantation Recipients. ( 26833657 )
2016
11
Lung Clearance Index (LCI) in Patients with Bronchiolitis Obliterans: A Preliminary Report and Comparison to Cystic Fibrosis Patients. ( 27645685 )
2016
12
Spirometry States the Obvious: Recognizing Bronchiolitis Obliterans Syndrome Early after Hematopoietic Cell Transplantation. ( 27831809 )
2016
13
Extracorporeal photopheresis as a new supportive therapy for bronchiolitis obliterans syndrome after allogeneic stem cell transplantation. ( 26726939 )
2016
14
Observational Study of Methotrexate in the Treatment of Bronchiolitis Obliterans Syndrome. ( 27931586 )
2016
15
Impact of long-term treatment with inhaled corticosteroids and bronchodilators on lung function in a patient with post-infectious bronchiolitis obliterans. ( 27383939 )
2016
16
Risk Factor and Clinical Outcome of Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation. ( 26847288 )
2016
17
Bronchiolitis Obliterans Organizing Pneumonia as an Initial Presentation of Systemic Lupus Erythematosus: A Rare Case Report and Literature Review. ( 27200095 )
2016
18
Hypoxemia is an independent predictor of bronchiolitis obliterans following respiratory adenoviral infection in children. ( 27722041 )
2016
19
MicroRNA-144 is unlikely to play a role in bronchiolitis obliterans syndromeTo the Editor. ( 27044533 )
2016
20
Hepatocyte growth factor enhances the inflammation-alleviating effect of umbilical cord-derived mesenchymal stromal cells in a bronchiolitis obliterans model. ( 26857230 )
2016
21
MicroRNA-144 is unlikely to play a role in bronchiolitis obliterans syndrome. ( 26874429 )
2016
22
Diagnosis and management of bronchiolitis obliterans syndrome following lung or hematopoietic cell transplantation. ( 26950825 )
2016
23
Evaluating bronchodilator response in pediatric patients with post-infectious bronchiolitis obliterans: use of different criteria for identifying airway reversibility. ( 27383929 )
2016
24
HMGB1 exacerbates bronchiolitis obliterans syndrome via RAGE/NF-I_B/HPSE signaling to enhance latent TGF-I^ release from ECM. ( 27347307 )
2016
25
Long Term Follow-Up of Sulfur Mustard Related Bronchiolitis Obliterans Treatment. ( 27832694 )
2016
26
How I treat bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. ( 27856461 )
2016
27
Bronchiolitis Obliterans: Pleading for a Pragmatic Approach. ( 26802324 )
2016
28
Parametric Response Mapping of Bronchiolitis Obliterans Syndrome Progression After Lung Transplantation. ( 27367568 )
2016
29
Identification of miRNAs Potentially Involved in Bronchiolitis Obliterans Syndrome: A Computational Study. ( 27564214 )
2016
30
Rescue alemtuzumab for refractory acute cellular rejection and bronchiolitis obliterans syndrome after lung transplantation. ( 28008661 )
2016
31
Imatinib ameliorates bronchiolitis obliterans via inhibition of fibrocyte migration and differentiation. ( 27388852 )
2016
32
Non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans. ( 27914107 )
2016
33
Epiplakin Is a Paraneoplastic Pemphigus Autoantigen and Related to Bronchiolitis Obliterans in Japanese Patients. ( 26802236 )
2016
34
Impaired Capacity of Fibroblasts to Support Airway Epithelial Progenitors in Bronchiolitis Obliterans Syndrome. ( 27569228 )
2016
35
Bronchiolitis obliterans following hematopoietic stem cell transplantation: Importance of expiratory computed tomography. ( 27745931 )
2016
36
Bronchiolitis Obliterans Syndrome (BOS) Following Lung Transplant. ( 27248598 )
2016
37
Proteomic characterization reveals that MMP-3 correlates with bronchiolitis obliterans syndrome following allogeneic hematopoietic cell and lung transplantation. ( 26887344 )
2016
38
Advances in Understanding Bronchiolitis Obliterans after lung transplantation. ( 27212132 )
2016
39
The Lymphatic Phenotype of Lung Allografts in Patients With Bronchiolitis Obliterans Syndrome and Restrictive Allograft Syndrome. ( 27163544 )
2016
40
Therapeutic effect of budesonide/formoterol, montelukast and N-acetylcysteine for bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. ( 27229850 )
2016
41
LPS-Responsive Beige-Like Anchor Gene Mutation Associated With Possible Bronchiolitis Obliterans Organizing Pneumonia Associated With Hypogammaglobulinemia and Normal IgM Phenotype and Low Number of B Cells. ( 27888588 )
2016
42
Diagnostic value of antineutrophil cytoplasmic antibodies in children with bronchiolitis obliterans. ( 27293851 )
2016
43
Bronchiolitis obliterans organizing pneumonia associated with achalasia: A case report. ( 27408784 )
2016
44
Differences of airway dimensions between patients with and without bronchiolitis obliterans syndrome after lung transplantation-Computer-assisted quantification of computed tomography. ( 27423681 )
2016
45
Infections and neutrophils in the pathogenesis of bronchiolitis obliterans syndrome in children after allogeneic stem cell transplantation. ( 26918734 )
2016
46
Current research on pediatric patients with bronchiolitis obliterans in Brazil. ( 25674382 )
2015
47
Post-infectious bronchiolitis obliterans in children: CT features that predict responsiveness to pulse methylprednisolone. ( 25710129 )
2015
48
Pulmonary hypertension associated with bronchiolitis obliterans after hematopoietic stem cell transplantation. ( 26479977 )
2015
49
Budesonide/Formoterol for Bronchiolitis Obliterans After Hematopoietic Stem Cell Transplantation. ( 25835160 )
2015
50
Epiplakin is a Paraneoplastic Pemphigus Autoantigen and Related to Bronchiolitis Obliterans in Japanese Patients. ( 26480281 )
2015

Variations for Bronchiolitis Obliterans

Expression for Bronchiolitis Obliterans

Search GEO for disease gene expression data for Bronchiolitis Obliterans.

Pathways for Bronchiolitis Obliterans

Pathways related to Bronchiolitis Obliterans according to GeneCards Suite gene sharing:

(show top 50) (show all 80)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CXCL8 IFNG IL10 IL17A IL6 MMP8
2
Show member pathways
13.87 CXCL8 CXCR3 IL10 IL17A IL6 PDGFB
3
Show member pathways
13.67 CXCL8 CXCR3 IFNG IL10 IL17A IL6
4
Show member pathways
13.57 CXCL8 IFNG IL10 IL17A IL6 PDGFB
5
Show member pathways
13.43 CXCL8 CXCR3 IL10 IL17A IL6 PDGFB
6
Show member pathways
13.37 CXCL8 IFNG IL10 IL17A IL6 MMP9
7
Show member pathways
13.33 CXCL8 CXCR3 IL10 IL17A IL6 PDGFB
8
Show member pathways
12.95 CXCL8 IFNG IL10 IL6 MMP9 TGFB1
9
Show member pathways
12.87 CXCL8 GZMB IFNG IL10 IL17A IL6
10
Show member pathways
12.8 MMP7 MMP8 MMP9 PDGFB TGFB1 TIMP1
11
Show member pathways
12.74 IL6 PDGFB TGFB1 TIMP1 TNF
12 12.71 CXCL8 IL6 MMP9 PDGFB TGFB1
13
Show member pathways
12.66 IFNG IL10 IL17A IL6 TGFB1 TNF
14
Show member pathways
12.64 IFNG IL10 IL17A IL6 PDGFB TIMP1
15 12.59 GZMB IFNG IL10 IL17A TNF
16
Show member pathways
12.51 IFNG IL10 IL17A IL6 TGFB1 TNF
17 12.45 IL6 PDGFB TGFB1 TNF
18
Show member pathways
12.39 CXCL8 IFNG IL17A IL6 MMP9 TNF
19
Show member pathways
12.31 CXCL8 IFNG IL6 TNF
20
Show member pathways
12.3 IFNG IL10 TGFB1 TNF
21 12.3 IFNG IL10 IL6 TGFB1 TNF
22 12.28 CXCL8 GZMB IL6 MMP9
23 12.24 IFNG IL6 MMP7 MMP9 TGFB1 TNF
24
Show member pathways
12.23 CXCL8 IFNG IL6 TNF
25 12.22 CXCL8 IL10 IL6 TNF
26
Show member pathways
12.2 CXCL8 IFNG IL10 IL17A IL6 TNF
27 12.15 IFNG MMP9 PDGFB TNF
28 12.06 IFNG IL10 IL6 TNF
29 12.03 CXCL8 IFNG IL6 MMP9 TGFB1 TNF
30 12.02 CXCL8 IFNG IL6 TGFB1
31
Show member pathways
12 GZMB IFNG IL17A IL6 TGFB1
32 11.98 CXCL8 IL6 TGFB1 TNF
33
Show member pathways
11.98 MMP7 MMP8 MMP9 TIMP1 TNF
34 11.97 IL6 MMP9 TNF
35
Show member pathways
11.96 IFNG IL10 IL17A IL6 TGFB1 TNF
36
Show member pathways
11.95 CXCL8 IL17A IL6 TGFB1
37 11.92 IFNG IL6 TIMP1
38 11.92 MMP7 MMP9 TGFB1 TIMP1
39 11.91 IL6 PDGFB TGFB1
40 11.86 CXCL8 IFNG IL6
41 11.86 CXCL8 IFNG IL10 IL6 TGFB1 TNF
42 11.85 IFNG TGFB1 TNF
43 11.85 IFNG IL10 IL6 TGFB1 TNF
44 11.84 CXCL8 IL10 IL6 TNF
45 11.83 CXCL8 IFNG IL6
46
Show member pathways
11.8 CXCL8 IFNG TNF
47 11.8 IL10 IL6 TGFB1 TNF
48 11.8 CXCL8 IFNG IL17A IL6 TGFB1 TNF
49 11.75 IL6 PDGFB TGFB1 TIMP1
50 11.74 IFNG IL10 IL6

GO Terms for Bronchiolitis Obliterans

Cellular components related to Bronchiolitis Obliterans according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 CXCR3 MMP7 PDGFB TGFB1 TNF
2 extracellular region GO:0005576 9.77 CXCL8 IFNG IL10 IL17A IL6 MMP7
3 proteinaceous extracellular matrix GO:0005578 9.72 MMP7 MMP8 MMP9 TGFB1 TIMP1
4 external side of plasma membrane GO:0009897 9.65 CXCR3 IFNG IL17A IL6 TNF
5 extracellular matrix GO:0031012 9.63 MMP7 MMP8 MMP9 PDGFB TGFB1 TIMP1
6 platelet alpha granule lumen GO:0031093 9.54 PDGFB TGFB1 TIMP1
7 extracellular space GO:0005615 9.44 CXCL8 IFNG IL10 IL17A IL6 MMP7

Biological processes related to Bronchiolitis Obliterans according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.97 IFNG IL6 MMP9 TGFB1 TNF
2 response to drug GO:0042493 9.97 IFNG IL10 IL6 SCGB1A1 TGFB1
3 immune response GO:0006955 9.97 CXCL8 IFNG IL10 IL17A IL6 TNF
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.95 IL6 PDGFB TGFB1 TNF
5 negative regulation of gene expression GO:0010629 9.94 IFNG PDGFB TGFB1 TNF
6 positive regulation of protein phosphorylation GO:0001934 9.92 IFNG MMP9 TGFB1 TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.9 IL10 IL6 TNF
8 wound healing GO:0042060 9.9 IL6 TGFB1 TIMP1
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.89 IL6 PDGFB TGFB1
10 movement of cell or subcellular component GO:0006928 9.88 CXCL8 CXCR3 IFNG
11 positive regulation of protein kinase B signaling GO:0051897 9.88 IL6 TGFB1 TNF
12 response to wounding GO:0009611 9.88 IL6 PDGFB TGFB1
13 cellular response to interleukin-1 GO:0071347 9.87 CXCL8 IL17A IL6
14 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.87 IL6 TGFB1 TNF
15 collagen catabolic process GO:0030574 9.86 MMP7 MMP8 MMP9
16 response to cytokine GO:0034097 9.85 IL6 SCGB1A1 TIMP1
17 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 IL6 PDGFB TNF
18 positive regulation of MAP kinase activity GO:0043406 9.85 PDGFB TGFB1 TNF
19 humoral immune response GO:0006959 9.83 IFNG IL6 TNF
20 negative regulation of fat cell differentiation GO:0045599 9.81 IL6 TGFB1 TNF
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 IFNG IL6 TNF
22 extrinsic apoptotic signaling pathway GO:0097191 9.8 IFNG TGFB1 TNF
23 negative regulation of T cell proliferation GO:0042130 9.78 IL10 SCGB1A1 TGFB1
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IFNG TNF
25 cell activation GO:0001775 9.73 TGFB1 TIMP1
26 cellular response to hepatocyte growth factor stimulus GO:0035729 9.73 IL10 IL6
27 extracellular matrix disassembly GO:0022617 9.73 MMP7 MMP8 MMP9 TIMP1
28 response to molecule of bacterial origin GO:0002237 9.72 CXCL8 IL10
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 TNF
30 positive regulation of chemotaxis GO:0050921 9.72 PDGFB TGFB1
31 positive regulation of protein import into nucleus, translocation GO:0033160 9.72 IFNG IL6
32 protein import into nucleus, translocation GO:0000060 9.72 IFNG TGFB1 TNF
33 aging GO:0007568 9.72 IL10 IL6 MMP7 TGFB1 TIMP1
34 negative regulation of interleukin-17 production GO:0032700 9.71 IFNG TGFB1
35 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IFNG TNF
36 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
37 negative regulation of mitotic cell cycle GO:0045930 9.7 IL10 TGFB1 TNF
38 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
39 positive regulation of MHC class II biosynthetic process GO:0045348 9.69 IFNG IL10
40 positive regulation of protein complex assembly GO:0031334 9.69 IFNG TGFB1 TNF
41 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.68 IL10 TIMP1
42 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
43 response to glucocorticoid GO:0051384 9.67 IL10 IL6 SCGB1A1 TNF
44 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.66 IL6 TNF
45 positive regulation of interleukin-23 production GO:0032747 9.65 IFNG IL17A
46 positive regulation of osteoclast differentiation GO:0045672 9.65 IFNG IL17A TNF
47 cellular response to lipopolysaccharide GO:0071222 9.65 CXCL8 IFNG IL10 IL6 TNF
48 positive regulation of mononuclear cell migration GO:0071677 9.64 TGFB1 TNF
49 defense response to protozoan GO:0042832 9.63 IFNG IL10 IL6
50 receptor biosynthetic process GO:0032800 9.6 IL10 TNF

Molecular functions related to Bronchiolitis Obliterans according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.46 GZMB MMP7 MMP8 MMP9
2 growth factor activity GO:0008083 9.35 IL10 IL6 PDGFB TGFB1 TIMP1
3 cytokine activity GO:0005125 9.23 CXCL8 IFNG IL10 IL17A IL6 TGFB1

Sources for Bronchiolitis Obliterans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....