MCID: BRN012
MIFTS: 50

Bronchiolitis Obliterans malady

Rare diseases category

Summaries for Bronchiolitis Obliterans

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NIH Rare Diseases:41 Bronchiolitis obliterans is an inflammatory obstruction of the lung's tiniest airways, the bronchioles. the bronchioles may become damaged and inflamed after inhalation of toxic fumes, as a result of respiratory infections, in association with connective tissue disorders, or after bone marrow or heart-lung transplants. this leads to extensive scarring that blocks the airways, leading to a dry cough, shortness of breath, fatigue and wheezing in the absence of a cold or asthma. while there is no way to reverse the disease, treatments are available to stabilize or slow the progression.   another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease. last updated: 10/1/2012

MalaCards based summary: Bronchiolitis Obliterans, also known as bronchiolitis fibrosa obliterans, is related to bronchiolitis and pneumonia. An important gene associated with Bronchiolitis Obliterans is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are Selected targets of C EBPalpha and Cytokine production by Th17 cells in CF. The compounds p002 and mcp 1 have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow, and related mouse phenotypes are renal/urinary system and respiratory system.

Disease Ontology:9 A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults.

Wikipedia:63 Bronchiolitis obliterans (BO), also called obliterative bronchiolitis (OB) and constrictive... more...

Aliases & Classifications for Bronchiolitis Obliterans

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Bronchiolitis Obliterans, Aliases & Descriptions:

Name: Bronchiolitis Obliterans 30 9 41 11 43 60
Bronchiolitis Fibrosa Obliterans 9 60
Obliterative Bronchiolitis 9 41
 
Bronchiolitis, Exudative 60
Bronchiolitis Exudativa 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:2799
NCIt38 C62580
SNOMED-CT55 31886003, 40100001
MeSH33 D001989

Related Diseases for Bronchiolitis Obliterans

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Diseases related to Bronchiolitis Obliterans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1bronchiolitis33.0IL8
2pneumonia31.7SCGB1A1, IL8, IL17A, CXCL10, MMP8
3arthritis31.3IL8, IL17A
4systemic lupus erythematosus31.0IL17A, CXCL10, CXCR3
5respiratory failure31.0SCGB1A1, CXCL10
6cystic fibrosis30.9IL17A, IL8, SCGB1A1
7colitis30.9IL17A, IL8, CXCL10
8bronchiectasis30.6IL8, MMP8
9ulcerative colitis30.6CXCL10, CXCR3, IL17A, IL8
10rheumatoid arthritis30.6IL8, IL17A, CXCL10, CXCR3, MMP8
11breast cancer30.5IL17A, CXCR3, CXCL10, MMP8, SCGB1A1
12pulmonary sarcoidosis30.5PDGFB, CXCR3
13lung cancer30.5MMP8, SCGB1A1, PDGFB, CXCR3
14tuberculosis30.5IL17A, PDGFB, CXCR3, CXCL10
15pulmonary fibrosis30.4CXCR3, IL8, PDGFB
16hepatitis30.3CXCL10, PDGFB, IFNA2
17leukemia30.2PDGFB, SCGB1A1, IFNA2, CXCR3, IL17A
18hepatitis b30.2CXCL10, IFNA2, IL17A
19hepatitis c30.1CXCL10, CXCR3, IFNA2
20asthma29.6CXCL10, IL8, MMP8, CXCR3, IL17A, SCGB1A1
21bronchiolitis obliterans organizing pneumonia11.4
22hematopoietic stem cell transplantation11.0
23pemphigus10.7
24paraneoplastic pemphigus10.7
25cryptogenic organizing pneumonia10.7
26lupus erythematosus10.6
27chronic graft versus host disease10.6
28pneumothorax10.6
29pulmonary function10.6
30castleman's disease10.5
31funisitis10.5MMP8
32chronic eosinophilic pneumonia10.5
33eosinophilic pneumonia10.5
34gastroesophageal reflux10.4
35scleroderma10.4
36acute respiratory distress syndrome10.4
37polymyositis10.4
38common cold10.4IL8
39b-cell lymphomas10.3
40acute interstitial pneumonia10.3
41juvenile rheumatoid arthritis10.3
42measles10.3
43dermatomyositis10.3
44ischemia10.3
45mediastinitis10.3
46spontaneous pneumothorax10.3
47gingivitis10.3IL17A, MMP8
48periapical granuloma10.3MMP8, CXCR3
49polyarteritis nodosa10.3IFNA2
50chronic ulcer of skin10.3PDGFB, MMP8

Graphical network of the top 20 diseases related to Bronchiolitis Obliterans:



Diseases related to bronchiolitis obliterans

Symptoms for Bronchiolitis Obliterans

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Drugs & Therapeutics for Bronchiolitis Obliterans

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Drug clinical trials:

Search ClinicalTrials for Bronchiolitis Obliterans

Search NIH Clinical Center for Bronchiolitis Obliterans

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bronchiolitis Obliterans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchiolitis Obliterans:
Mesenchymal stem cells for obliterative bronchiolitis
Embryonic/Adult Cultured Cells Related to Bronchiolitis Obliterans:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Bronchiolitis Obliterans

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Anatomical Context for Bronchiolitis Obliterans

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MalaCards organs/tissues related to Bronchiolitis Obliterans:

31
Lung, Bone, Bone marrow, Heart, Breast, T cells, Colon, Liver, B cells, Testes, Kidney, Neutrophil, Thymus, Smooth muscle, Thyroid, Trachea

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Bronchiolitis Obliterans:
id TissueAnatomical CompartmentCell Relevance
1 LungRespiratory BronchiolesCilliated Cells Potential therapeutic candidate, affected by disease

Animal Models for Bronchiolitis Obliterans or affiliated genes

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MGI Mouse Phenotypes related to Bronchiolitis Obliterans:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9SCGB1A1, CXCR3, IL17A, PDGFB
2MP:00053888.6SCGB1A1, CXCR3, IL17A, PDGFB
3MP:00053978.1PDGFB, IL8, IL17A, CXCR3, CXCL10
4MP:00107687.8SCGB1A1, CXCL10, CXCR3, IL17A, MAPKAP1, PDGFB
5MP:00053877.5PDGFB, IL8, IL17A, CXCR3, CXCL10, MMP8

Publications for Bronchiolitis Obliterans

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Articles related to Bronchiolitis Obliterans:

(show top 50)    (show all 733)
idTitleAuthorsYear
1
Local Origin of Mesenchymal Cells in a Murine Orthotopic Lung Transplantation Model of Bronchiolitis Obliterans. (25848843)
2015
2
Predictive Value of Bronchiolitis Obliterans Syndrome Stage 0p in Chronic Graft-versus-Host Disease of the Lung. (25687798)
2015
3
Effects of prophylactic use of sirolimus on bronchiolitis obliterans syndrome development in lung transplant recipients. (24119986)
2014
4
Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans. (24820310)
2014
5
Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study. (24852165)
2014
6
Follow-up on pediatric patients with bronchiolitis obliterans treated with corticosteroid pulse therapy. (25124141)
2014
7
Aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans. (23062110)
2013
8
Chest health surveillance utility in the early detection of bronchiolitis obliterans syndrome in children after allo-SCT. (23165500)
2013
9
A relevant experimental model for human bronchiolitis obliterans syndrome. (24050896)
2013
10
Risk factors for bronchiolitis obliterans syndrome in allogeneic hematopoietic stem cell transplantation. (23823823)
2013
11
Treatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model. (24199758)
2013
12
Bronchiolitis obliterans syndrome: the Achilles' heel of lung transplantation. (23821508)
2013
13
Rapid acute onset of bronchiolitis obliterans syndrome in a lung transplant recipient after respiratory syncytial virus infection. (22650803)
2012
14
Bronchiolitis obliterans syndrome is associated with increased peripheral blood natural killer and natural killer T-like granzymes, perforin, and T-helper-type 1 pro-inflammatory cytokines. (22759800)
2012
15
Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. (22869493)
2012
16
Radiation-induced bronchiolitis obliterans organizing pneumonia: a case report and literature review. (23187778)
2012
17
Bronchiolitis obliterans in children: a ghostly journey to the origin. (21872382)
2011
18
Histopathological bronchial reconstruction of human bronchiolitis obliterans. (21418391)
2011
19
HBs seroconversion in a patient with acute hepatitis B treated with entecavir during immunosuppression against severe bronchiolitis obliterans in the course of chronic graft versus host disease. (20403727)
2010
20
Local IL-17 production and a decrease in peripheral blood regulatory T cells in an animal model of bronchiolitis obliterans. (20393404)
2010
21
The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation. (20456980)
2010
22
Systemic and exhaled cytokine and chemokine profiles are associated with the development of bronchiolitis obliterans syndrome. (20627628)
2010
23
Air-leak and transient coronary artery dilation in post-infectious bronchiolitis obliterans. (20958871)
2010
24
Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease. (19896545)
2010
25
The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation. (19299743)
2009
26
Effect of maintenance azithromycin on established bronchiolitis obliterans syndrome in lung transplant patients. (18551201)
2008
27
Soluble CD30 levels as a diagnostic marker for bronchiolitis obliterans syndrome following human lung transplantation. (18047935)
2008
28
Bronchiolitis obliterans syndrome: alloimmune-dependent and -independent injury with aberrant tissue remodeling. (18707652)
2008
29
Bronchiolitis obliterans syndrome and survival following lung transplantation for patients with sarcoidosis. (19382530)
2008
30
Lung transplantation in the Fischer 344-->Wistar Kyoto rat strain combination is not suitable to study bronchiolitis obliterans. (17403482)
2007
31
Improvement of pulmonary function with imatinib mesylate in bronchiolitis obliterans following allogeneic hematopoietic cell transplantation. (16785069)
2006
32
Comparison of mycophenolate mofetil and azathioprine for prevention of bronchiolitis obliterans syndrome in de novo lung transplant recipients. (16612275)
2006
33
Lower incidence of Bronchiolitis obliterans in allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning compared with myeloablative conditioning. (15852024)
2005
34
Bronchiolitis obliterans organising pneumonia: a treatable condition. (16114165)
2005
35
Is it bronchiolitis obliterans syndrome or is it chronic rejection: a reappraisal? (15684284)
2005
36
The incidence and clinical characteristics of bronchiolitis obliterans organizing pneumonia syndrome after radiation therapy for breast cancer. (15554078)
2004
37
Solitary nodular form of bronchiolitis obliterans organizing pneumonia. (15589500)
2004
38
A case of bronchiolitis obliterans organizing pneumonia syndrome with preceding radiation pneumonitis after breast-conserving therapy. (15640508)
2004
39
Bronchiolitis obliterans organizing pneumonia associated with sulfasalazine in a patient with rheumatoid arthritis. (15168156)
2004
40
A case of loxoprofen sodium-induced bronchiolitis obliterans organizing pneumonia (BOOP)]. (14727549)
2003
41
Increased exhaled nitric oxide in bronchiolitis obliterans organizing pneumonia after allogeneic bone marrow transplantation. (12451281)
2002
42
Bronchiolitis obliterans organizing pneumonia associated with Evans syndrome. (11786723)
2001
43
Bronchiolitis obliterans organizing pneumonia. Trying to answer an intriguing question. (11185490)
2000
44
Intraluminal fibromyxoid lesions in bronchiolitis obliterans organizing pneumonia are highly capillarized. (10534166)
1999
45
Platelet-derived growth factor in bronchiolitis obliterans-organizing pneumonia. (9032212)
1997
46
Bronchiolitis obliterans organizing pneumonia associated with systemic lupus erythematosus with antiphospholipid antibody. (8739795)
1996
47
Bronchiolitis obliterans in a patient with localized scleroderma treated with D-penicillamine. (8804954)
1996
48
Chronic eosinophilic pneumonia and idiopathic bronchiolitis obliterans organizing pneumonia: comparison of eosinophil number and degranulation by immunofluorescence staining for eosinophil-derived major basic protein. (7531262)
1995
49
Bronchiolitis obliterans-organizing pneumonia (BOOP) in children with malignant disease. (1523049)
1992
50
Radiographic manifestations of bronchiolitis obliterans with organizing pneumonia vs usual interstitial pneumonia. (3490161)
1986

Variations for Bronchiolitis Obliterans

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Expression for genes affiliated with Bronchiolitis Obliterans

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Search GEO for disease gene expression data for Bronchiolitis Obliterans.

Pathways for genes affiliated with Bronchiolitis Obliterans

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Pathways related to Bronchiolitis Obliterans according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5IL8, IL17A
29.2IFNA2, CXCL10
39.1MAPKAP1, CXCR3, CXCL10
49.0IL8, IFNA2
5
Show member pathways
9.0CXCL10, CXCR3, IL8
6
Show member pathways
9.0CXCL10, CXCR3, IL8
7
Show member pathways
8.6MMP8, CXCL10, CXCR3, IL8
8
Show member pathways
8.6IL8, IFNA2, CXCL10
9
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.6IL8, IFNA2, CXCL10
10
Show member pathways
8.6IL8, IFNA2, CXCL10
11
Show member pathways
8.5CXCL10, CXCR3, IL8, PDGFB
12
Show member pathways
8.5CXCL10, CXCR3, IL8, PDGFB
13
Show member pathways
8.5CXCL10, CXCR3, IL8, PDGFB
14
Show member pathways
7.9CXCL10, CXCR3, IL8, MAPKAP1, PDGFB
15
Show member pathways
7.3PDGFB, CXCL10, CXCR3, IFNA2, IL17A, IL8

Compounds for genes affiliated with Bronchiolitis Obliterans

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Compounds related to Bronchiolitis Obliterans according to GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1p002439.8IL17A, MMP8, SCGB1A1
2mcp 1439.8CXCR3, IL8
3flagellin43 2810.8IL8, CXCR3
4polycarbonate439.7IL8, CXCL10
5ns 39843 5910.7IL17A, IL8
6fluticasone propionate43 49 59 1212.7CXCL10, IL8
7ccl443 2810.6CXCL10, CXCR3, IL17A
8allergens439.6CXCR3, CXCL10
9polyinosinic-polycytidylic acid439.5CXCL10, IL8
10poly(i-c)439.5IL8, CXCL10
11doxycycline43 1210.5MMP8, SCGB1A1
12methacholine43 49 1211.5IL8, IL17A
13il 10439.4IL8, CXCR3, CXCL10
14tarc439.4IL8, CXCR3, CXCL10
15ccl343 2810.4IL8, CXCR3, CXCL10
162,5-oligoadenylate439.4CXCL10, IFNA2
17hydrocortisone43 2 59 1212.3IL8, CXCR3, CXCL10
18imiquimod43 59 28 1212.3IFNA2, IL8
19matrigel439.3IL8, CXCR3, CXCL10
20ly294002439.3IL8, IL17A, CXCR3
21creatinine439.3SCGB1A1, CXCL10, CXCR3, IL17A
22phosphatidylinositol439.2SCGB1A1, CXCL10, CXCR3, IL17A
23ribavirin43 49 1211.2CXCL10, CXCR3, IFNA2
24tacrolimus43 49 1211.1PDGFB, IL17A, CXCR3, CXCL10
25genistein43 28 59 2 24 1214.1MMP8, CXCL10, IL8
26groalpha439.1IL8, IL17A, CXCR3, CXCL10
27cyclosporin a43 28 5911.0MMP8, IL17A, IL8, PDGFB
28neopterin439.0CXCL10, IFNA2, IL8
29erythromycin43 2 49 1211.9IL8, IFNA2
30pd 98,059438.9PDGFB, IL8, IL17A, CXCR3
31steroid438.9SCGB1A1, CXCR3, IFNA2, IL17A
32infliximab43 49 1210.9CXCL10, CXCR3, IFNA2, IL17A
33ifn-alpha438.8CXCL10, CXCR3, IFNA2, IL17A
34alanine438.8IFNA2, CXCL10, MMP8, SCGB1A1
35endotoxin438.7SCGB1A1, CXCL10, CXCR3, IL17A, IL8
36pge2438.7MMP8, CXCL10, CXCR3, IL17A, IL8
37etanercept43 49 1210.7IL8, IL17A, IFNA2, CXCR3
38superoxide43 249.6MMP8, CXCR3, IFNA2, IL8
39glucose438.6PDGFB, IFNA2, CXCL10, MMP8
40histamine43 28 2410.6IL8, IFNA2, CXCR3, CXCL10
41rantes438.5CXCL10, CXCR3, IL17A, IL8, MAPKAP1
42dexamethasone43 49 28 1211.5CXCL10, CXCR3, IL17A, IL8, PDGFB
43thymidine43 249.3CXCL10, CXCR3, IFNA2, IL17A, PDGFB
44tyrosine438.2CXCL10, CXCR3, IFNA2, IL17A, PDGFB
45lipid438.0SCGB1A1, MMP8, CXCL10, IFNA2, IL17A, PDGFB
46progesterone43 28 59 24 1212.0SCGB1A1, MMP8, CXCL10, CXCR3, IFNA2, PDGFB
47estrogen438.0SCGB1A1, CXCL10, CXCR3, IFNA2, IL17A, PDGFB
48nitric oxide43 24 129.9SCGB1A1, MMP8, CXCL10, CXCR3, IL17A, IL8
49oxygen43 248.9SCGB1A1, MMP8, CXCR3, IFNA2, IL8, PDGFB
50vegf437.4PDGFB, MMP8, CXCL10, CXCR3, IFNA2, IL17A

GO Terms for genes affiliated with Bronchiolitis Obliterans

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Cellular components related to Bronchiolitis Obliterans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.2IL17A, CXCR3, CXCL10
2extracellular regionGO:00055767.4PDGFB, MMP8, CXCL10, IFNA2, IL8
3extracellular spaceGO:00056156.9IL17A, SCGB1A1, MMP8, CXCL10, IFNA2, PDGFB

Biological processes related to Bronchiolitis Obliterans according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:00308169.9CXCL10, CXCR3
2T cell chemotaxisGO:00108189.9CXCR3, CXCL10
3positive regulation of cAMP-mediated signalingGO:00439509.8CXCR3, CXCL10
4positive regulation of release of sequestered calcium ion into cytosolGO:00512819.8CXCL10, CXCR3
5positive regulation of chemotaxisGO:00509219.8PDGFB, CXCR3
6cellular response to interleukin-1GO:00713479.6IL17A, IL8
7calcium-mediated signalingGO:00197229.4CXCR3, IL8
8negative regulation of angiogenesisGO:00165259.3CXCR3, CXCL10
9chemotaxisGO:00069359.2CXCL10, CXCR3, IL8
10positive regulation of cell proliferationGO:00082849.1PDGFB, CXCR3, CXCL10
11G-protein coupled receptor signaling pathwayGO:00071869.1IL8, CXCR3, CXCL10
12cell surface receptor signaling pathwayGO:00071669.0IFNA2, CXCR3, CXCL10
13cell-cell signalingGO:00072679.0IL17A, IFNA2, CXCL10
14immune responseGO:00069558.9IL8, IL17A, CXCL10
15inflammatory responseGO:00069548.1IL8, IL17A, IFNA2, CXCR3, CXCL10

Molecular functions related to Bronchiolitis Obliterans according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.4IL8, CXCL10

Products for genes affiliated with Bronchiolitis Obliterans

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Sources for Bronchiolitis Obliterans

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet