MCID: BRN012
MIFTS: 60

Bronchiolitis Obliterans malady

Rare diseases, Respiratory diseases categories
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Summaries for Bronchiolitis Obliterans

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NIH Rare Diseases:42 Bronchiolitis obliterans is an inflammatory obstruction of the lung's tiniest airways, the bronchioles. the bronchioles may become damaged and inflamed after inhalation of toxic fumes, as a result of respiratory infections, in association with connective tissue disorders, or after bone marrow or heart-lung transplants. this leads to extensive scarring that blocks the airways, leading to a dry cough, shortness of breath, fatigue and wheezing in the absence of a cold or asthma. while there is no way to reverse the disease, treatments are available to stabilize or slow the progression.   another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease. last updated: 10/1/2012

MalaCards based summary: Bronchiolitis Obliterans, also known as obliterative bronchiolitis, is related to bronchiolitis and pneumonia. An important gene associated with Bronchiolitis Obliterans is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are Selected targets of C EBPalpha and Cytokine production by Th17 cells in CF. The compounds p002 and mcp 1 have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow, and related mouse phenotypes are renal/urinary system and respiratory system.

Disease Ontology:8 A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults.

Wikipedia:65 Bronchiolitis obliterans (BO), also called obliterative bronchiolitis (OB) and constrictive... more...

Aliases & Classifications for Bronchiolitis Obliterans

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Bronchiolitis Obliterans, Aliases & Descriptions:

Name: Bronchiolitis Obliterans 30 8 42 10 44 62
Obliterative Bronchiolitis 8 42 62
Bronchiolitis Fibrosa Obliterans 8 62
 
Bronchiolitis, Exudative 62
Bronchiolitis Exudativa 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:2799
MeSH34 D001989
SNOMED-CT57 40100001, 31886003
NCIt39 C62580

Related Diseases for Bronchiolitis Obliterans

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Diseases related to Bronchiolitis Obliterans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1bronchiolitis33.0IL8
2pneumonia31.7SCGB1A1, IL8, IL17A, CXCL10, MMP8
3arthritis31.3IL8, IL17A
4systemic lupus erythematosus31.0IL17A, CXCL10, CXCR3
5respiratory failure31.0SCGB1A1, CXCL10
6cystic fibrosis30.9IL17A, IL8, SCGB1A1
7colitis30.9IL17A, IL8, CXCL10
8sarcoidosis30.6SCGB1A1, CXCR3, PDGFB, CXCL10
9ulcerative colitis30.6CXCL10, CXCR3, IL17A, IL8
10rheumatoid arthritis30.6IL8, IL17A, CXCL10, CXCR3, MMP8
11bronchiectasis30.6IL8, MMP8
12breast cancer30.5IL17A, CXCR3, CXCL10, MMP8, SCGB1A1
13pulmonary sarcoidosis30.5PDGFB, CXCR3
14tuberculosis30.5IL17A, PDGFB, CXCR3, CXCL10
15pulmonary fibrosis30.4CXCR3, IL8, PDGFB
16lung cancer30.4MMP8, SCGB1A1, PDGFB, CXCR3
17hepatitis30.3CXCL10, PDGFB, IFNA2
18leukemia30.2PDGFB, SCGB1A1, IFNA2, CXCR3, IL17A
19hepatitis b30.2CXCL10, IFNA2, IL17A
20hepatitis c30.1CXCL10, CXCR3, IFNA2
21idiopathic pulmonary fibrosis29.7SCGB1A1, CXCL10, CXCR3, IL8, PDGFB
22chronic obstructive pulmonary disease29.6CXCR3, IL8, IL17A, SCGB1A1, CXCL10, MMP8
23asthma29.6CXCL10, IL8, MMP8, CXCR3, IL17A, SCGB1A1
24bronchiolitis obliterans organizing pneumonia11.4
25hematopoietic stem cell transplantation11.0
26pemphigus10.7
27paraneoplastic pemphigus10.7
28cryptogenic organizing pneumonia10.7
29graft versus host disease10.6
30lupus erythematosus10.6
31chronic graft versus host disease10.6
32pneumothorax10.6
33castleman's disease10.5
34usual interstitial pneumonia10.5
35pulmonary function10.5
36funisitis10.5MMP8
37chronic eosinophilic pneumonia10.5
38eosinophilic pneumonia10.5
39hodgkin's lymphoma10.4
40stevens-johnson syndrome10.4
41scleroderma10.4
42polymyositis10.4
43common cold10.4IL8
44gingivitis10.3IL17A, MMP8
45b-cell lymphomas10.3
46acute interstitial pneumonia10.3
47juvenile rheumatoid arthritis10.3
48wegener's granulomatosis10.3
49gastroesophageal reflux disease10.3
50measles10.3

Graphical network of the top 20 diseases related to Bronchiolitis Obliterans:



Diseases related to bronchiolitis obliterans

Symptoms for Bronchiolitis Obliterans

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Drugs & Therapeutics for Bronchiolitis Obliterans

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Drug clinical trials:

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Search NIH Clinical Center for Bronchiolitis Obliterans

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bronchiolitis Obliterans cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchiolitis Obliterans:
Mesenchymal stem cells for obliterative bronchiolitis
Embryonic/Adult Cultured Cells Related to Bronchiolitis Obliterans:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Bronchiolitis Obliterans

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Anatomical Context for Bronchiolitis Obliterans

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MalaCards organs/tissues related to Bronchiolitis Obliterans:

32
Lung, Bone, Bone marrow, Heart, Breast, T cells, Colon, Liver, B cells, Testes, Neutrophil, Kidney, Thymus, Smooth muscle, Thyroid, Trachea

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bronchiolitis Obliterans:
id TissueAnatomical CompartmentCell Relevance
1 LungRespiratory BronchiolesCilliated Cells Potential therapeutic candidate, affected by disease

Animal Models for Bronchiolitis Obliterans or affiliated genes

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MGI Mouse Phenotypes related to Bronchiolitis Obliterans:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9SCGB1A1, CXCR3, IL17A, PDGFB
2MP:00053888.6SCGB1A1, CXCR3, IL17A, PDGFB
3MP:00053978.1PDGFB, IL8, IL17A, CXCR3, CXCL10
4MP:00107687.8SCGB1A1, CXCL10, CXCR3, IL17A, MAPKAP1, PDGFB
5MP:00053877.5PDGFB, IL8, IL17A, CXCR3, CXCL10, MMP8

Publications for Bronchiolitis Obliterans

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Articles related to Bronchiolitis Obliterans:

(show top 50)    (show all 711)
idTitleAuthorsYear
1
Effects of prophylactic use of sirolimus on bronchiolitis obliterans syndrome development in lung transplant recipients. (24119986)
2014
2
Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans. (24820310)
2014
3
Ventilation/perfusion scintigraphy in children with post-infectious bronchiolitis obliterans: a pilot study. (24852165)
2014
4
Follow-up on pediatric patients with bronchiolitis obliterans treated with corticosteroid pulse therapy. (25124141)
2014
5
Aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans. (23062110)
2013
6
Chest health surveillance utility in the early detection of bronchiolitis obliterans syndrome in children after allo-SCT. (23165500)
2013
7
A relevant experimental model for human bronchiolitis obliterans syndrome. (24050896)
2013
8
Risk factors for bronchiolitis obliterans syndrome in allogeneic hematopoietic stem cell transplantation. (23823823)
2013
9
Treatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model. (24199758)
2013
10
Bronchiolitis obliterans syndrome: the Achilles' heel of lung transplantation. (23821508)
2013
11
Heterotopic tracheal transplantation animal model of bronchiolitis obliterans: A reproducible model. (24309319)
2013
12
Rapid acute onset of bronchiolitis obliterans syndrome in a lung transplant recipient after respiratory syncytial virus infection. (22650803)
2012
13
Bronchiolitis obliterans syndrome is associated with increased peripheral blood natural killer and natural killer T-like granzymes, perforin, and T-helper-type 1 pro-inflammatory cytokines. (22759800)
2012
14
Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. (22869493)
2012
15
Radiation-induced bronchiolitis obliterans organizing pneumonia: a case report and literature review. (23187778)
2012
16
Bronchiolitis obliterans in children: a ghostly journey to the origin. (21872382)
2011
17
Histopathological bronchial reconstruction of human bronchiolitis obliterans. (21418391)
2011
18
HBs seroconversion in a patient with acute hepatitis B treated with entecavir during immunosuppression against severe bronchiolitis obliterans in the course of chronic graft versus host disease. (20403727)
2010
19
Local IL-17 production and a decrease in peripheral blood regulatory T cells in an animal model of bronchiolitis obliterans. (20393404)
2010
20
The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation. (20456980)
2010
21
Systemic and exhaled cytokine and chemokine profiles are associated with the development of bronchiolitis obliterans syndrome. (20627628)
2010
22
Air-leak and transient coronary artery dilation in post-infectious bronchiolitis obliterans. (20958871)
2010
23
Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease. (19896545)
2010
24
The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation. (19299743)
2009
25
Effect of maintenance azithromycin on established bronchiolitis obliterans syndrome in lung transplant patients. (18551201)
2008
26
Soluble CD30 levels as a diagnostic marker for bronchiolitis obliterans syndrome following human lung transplantation. (18047935)
2008
27
Bronchiolitis obliterans syndrome: alloimmune-dependent and -independent injury with aberrant tissue remodeling. (18707652)
2008
28
Bronchiolitis obliterans syndrome and survival following lung transplantation for patients with sarcoidosis. (19382530)
2008
29
Lung transplantation in the Fischer 344-->Wistar Kyoto rat strain combination is not suitable to study bronchiolitis obliterans. (17403482)
2007
30
Living-donor lobar lung transplantation for broncho-bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: does bronchiolitis obliterans recur in transplanted lungs? (18055347)
2007
31
Comparison of mycophenolate mofetil and azathioprine for prevention of bronchiolitis obliterans syndrome in de novo lung transplant recipients. (16612275)
2006
32
Lower incidence of Bronchiolitis obliterans in allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning compared with myeloablative conditioning. (15852024)
2005
33
Bronchiolitis obliterans organising pneumonia: a treatable condition. (16114165)
2005
34
Is it bronchiolitis obliterans syndrome or is it chronic rejection: a reappraisal? (15684284)
2005
35
The incidence and clinical characteristics of bronchiolitis obliterans organizing pneumonia syndrome after radiation therapy for breast cancer. (15554078)
2004
36
Solitary nodular form of bronchiolitis obliterans organizing pneumonia. (15589500)
2004
37
A case of bronchiolitis obliterans organizing pneumonia syndrome with preceding radiation pneumonitis after breast-conserving therapy. (15640508)
2004
38
Bronchiolitis obliterans organizing pneumonia associated with sulfasalazine in a patient with rheumatoid arthritis. (15168156)
2004
39
A case of loxoprofen sodium-induced bronchiolitis obliterans organizing pneumonia (BOOP)]. (14727549)
2003
40
Increased exhaled nitric oxide in bronchiolitis obliterans organizing pneumonia after allogeneic bone marrow transplantation. (12451281)
2002
41
Bronchiolitis obliterans organizing pneumonia associated with Evans syndrome. (11786723)
2001
42
Bronchiolitis obliterans organizing pneumonia. Trying to answer an intriguing question. (11185490)
2000
43
Intraluminal fibromyxoid lesions in bronchiolitis obliterans organizing pneumonia are highly capillarized. (10534166)
1999
44
Platelet-derived growth factor in bronchiolitis obliterans-organizing pneumonia. (9032212)
1997
45
Bronchiolitis obliterans organizing pneumonia associated with systemic lupus erythematosus with antiphospholipid antibody. (8739795)
1996
46
Bronchiolitis obliterans in a patient with localized scleroderma treated with D-penicillamine. (8804954)
1996
47
Chronic eosinophilic pneumonia and idiopathic bronchiolitis obliterans organizing pneumonia: comparison of eosinophil number and degranulation by immunofluorescence staining for eosinophil-derived major basic protein. (7531262)
1995
48
Bronchiolitis obliterans organizing pneumonia associated with massive L-tryptophan ingestion. (8252993)
1993
49
Bronchiolitis obliterans-organizing pneumonia (BOOP) in children with malignant disease. (1523049)
1992
50
Radiographic manifestations of bronchiolitis obliterans with organizing pneumonia vs usual interstitial pneumonia. (3490161)
1986

Variations for Bronchiolitis Obliterans

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Expression for genes affiliated with Bronchiolitis Obliterans

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Expression patterns in normal tissues for genes affiliated with Bronchiolitis Obliterans

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Pathways for genes affiliated with Bronchiolitis Obliterans

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Pathways related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8SCGB1A1, MMP8
2
Show member pathways
9.5IL8, IL17A
39.2IFNA2, CXCL10
49.1MAPKAP1, CXCL10, CXCR3
59.0IL8, IFNA2
6
Show member pathways
9.0IL8, CXCR3, CXCL10
7
Show member pathways
9.0IL8, CXCR3, CXCL10
8
Show member pathways
8.6IL8, CXCR3, CXCL10, MMP8
9
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.6IFNA2, CXCL10, IL8
10
Show member pathways
8.6IL8, CXCL10, IFNA2
11
Show member pathways
8.6IFNA2, IL8, CXCL10
12
Show member pathways
8.5CXCR3, IL8, PDGFB, CXCL10
13
Show member pathways
8.5PDGFB, CXCL10, CXCR3, IL8
14
Show member pathways
8.5PDGFB, CXCL10, CXCR3, IL8
15
Show member pathways
7.9CXCR3, PDGFB, MAPKAP1, IL8, CXCL10
16
Show member pathways
7.3IFNA2, IL8, IL17A, PDGFB, CXCR3, CXCL10

Compounds for genes affiliated with Bronchiolitis Obliterans

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Compounds related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1p002449.8IL17A, MMP8, SCGB1A1
2mcp 1449.8CXCR3, IL8
3flagellin44 2810.8IL8, CXCR3
4polycarbonate449.7IL8, CXCL10
5ns 39844 6110.7IL17A, IL8
6fluticasone propionate44 50 61 1112.7CXCL10, IL8
7ccl444 2810.6CXCL10, CXCR3, IL17A
8allergens449.6CXCR3, CXCL10
9polyinosinic-polycytidylic acid449.5CXCL10, IL8
10poly(i-c)449.5IL8, CXCL10
11doxycycline44 1110.5MMP8, SCGB1A1
12methacholine44 50 1111.5IL8, IL17A
13il 10449.4IL8, CXCR3, CXCL10
14tarc449.4IL8, CXCR3, CXCL10
15ccl344 2810.4IL8, CXCR3, CXCL10
162,5-oligoadenylate449.4CXCL10, IFNA2
17hydrocortisone44 2 61 1112.3IL8, CXCR3, CXCL10
18imiquimod44 61 28 1112.3IFNA2, IL8
19matrigel449.3IL8, CXCR3, CXCL10
20ly294002449.3IL8, IL17A, CXCR3
21creatinine449.3SCGB1A1, CXCL10, CXCR3, IL17A
22phosphatidylinositol449.2SCGB1A1, CXCL10, CXCR3, IL17A
23ribavirin44 50 1111.2CXCL10, CXCR3, IFNA2
24tacrolimus44 50 1111.1PDGFB, IL17A, CXCR3, CXCL10
25genistein44 28 61 2 24 1114.1MMP8, CXCL10, IL8
26groalpha449.1IL8, IL17A, CXCR3, CXCL10
27cyclosporin a44 28 6111.0MMP8, IL17A, IL8, PDGFB
28neopterin449.0CXCL10, IFNA2, IL8
29erythromycin44 2 50 1111.9IL8, IFNA2
30pd 98,059448.9PDGFB, IL8, IL17A, CXCR3
31steroid448.9SCGB1A1, CXCR3, IFNA2, IL17A
32infliximab44 50 1110.9CXCL10, CXCR3, IFNA2, IL17A
33ifn-alpha448.8CXCL10, CXCR3, IFNA2, IL17A
34alanine448.8IFNA2, CXCL10, MMP8, SCGB1A1
35endotoxin448.7SCGB1A1, CXCL10, CXCR3, IL17A, IL8
36pge2448.7MMP8, CXCL10, CXCR3, IL17A, IL8
37etanercept44 50 1110.7IL8, IL17A, IFNA2, CXCR3
38superoxide44 249.6MMP8, CXCR3, IFNA2, IL8
39glucose448.6PDGFB, IFNA2, CXCL10, MMP8
40histamine44 28 2410.6IL8, IFNA2, CXCR3, CXCL10
41rantes448.5CXCL10, CXCR3, IL17A, IL8, MAPKAP1
42dexamethasone44 50 28 1111.5CXCL10, CXCR3, IL17A, IL8, PDGFB
43thymidine44 249.3CXCL10, CXCR3, IFNA2, IL17A, PDGFB
44tyrosine448.2CXCL10, CXCR3, IFNA2, IL17A, PDGFB
45lipid448.0SCGB1A1, MMP8, CXCL10, IFNA2, IL17A, PDGFB
46progesterone44 28 61 24 1112.0SCGB1A1, MMP8, CXCL10, CXCR3, IFNA2, PDGFB
47estrogen448.0SCGB1A1, CXCL10, CXCR3, IFNA2, IL17A, PDGFB
48nitric oxide44 24 119.9SCGB1A1, MMP8, CXCL10, CXCR3, IL17A, IL8
49oxygen44 248.9SCGB1A1, MMP8, CXCR3, IFNA2, IL8, PDGFB
50vegf447.4PDGFB, MMP8, CXCL10, CXCR3, IFNA2, IL17A

GO Terms for genes affiliated with Bronchiolitis Obliterans

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Cellular components related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2IL17A, CXCR3, CXCL10
2extracellular regionGO:0055767.4PDGFB, MMP8, CXCL10, IFNA2, IL8
3extracellular spaceGO:0056156.9IL17A, SCGB1A1, MMP8, CXCL10, IFNA2, PDGFB

Biological processes related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:0308169.9CXCL10, CXCR3
2T cell chemotaxisGO:0108189.9CXCR3, CXCL10
3positive regulation of cAMP-mediated signalingGO:0439509.8CXCR3, CXCL10
4positive regulation of release of sequestered calcium ion into cytosolGO:0512819.8CXCL10, CXCR3
5positive regulation of chemotaxisGO:0509219.8PDGFB, CXCR3
6cellular response to interleukin-1GO:0713479.6IL17A, IL8
7calcium-mediated signalingGO:0197229.4CXCR3, IL8
8negative regulation of angiogenesisGO:0165259.3CXCR3, CXCL10
9chemotaxisGO:0069359.2CXCL10, CXCR3, IL8
10positive regulation of cell proliferationGO:0082849.1PDGFB, CXCR3, CXCL10
11G-protein coupled receptor signaling pathwayGO:0071869.1IL8, CXCR3, CXCL10
12cell surface receptor signaling pathwayGO:0071669.0IFNA2, CXCR3, CXCL10
13cell-cell signalingGO:0072679.0IL17A, IFNA2, CXCL10
14immune responseGO:0069558.9IL8, IL17A, CXCL10
15inflammatory responseGO:0069548.1IL8, IL17A, IFNA2, CXCR3, CXCL10

Molecular functions related to Bronchiolitis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.4IL8, CXCL10

Products for genes affiliated with Bronchiolitis Obliterans

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Sources for Bronchiolitis Obliterans

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3CDC
13ExPASy
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22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
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28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
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58SNOMED-CT via Orphanet
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