Bronchiolitis Obliterans malady

NIH Rare Diseases: Bronchiolitis obliterans is an inflammatory obstruction of the lung's tiniest airways, the bronchioles. The bronchioles may become damaged and inflamed after inhalation of toxic fumes, as a result of respiratory infections, in association with connective tissue disorders, or after bone marrow or heart-lung transplants. This leads to extensive scarring that blocks the airways, leading to a dry cough, shortness of breath, fatigue and wheezing in the absence of a cold or asthma. While there is no way to reverse the disease, treatments are available to stabilize or slow the progression.   Another similarly named disease, bronchiolitis obliterans organizing pneumonia, is a completely different disease.³⁰

MalaCards: Bronchiolitis Obliterans, also known as obliterative bronchiolitis, is related to bronchiolitis obliterans organizing pneumonia and arthritis. An important gene associated with Bronchiolitis Obliterans is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and NFAT Signaling and Lymphocyte Interactions. The compounds ivig and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, thymus and heart, and related mouse phenotypes are respiratory system and renal/urinary system.

Disease Ontology: A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults.⁶

Wikipedia: Bronchiolitis obliterans (BO), also called obliterative bronchiolitis (OB) and constrictive...⁴⁴ more...

Aliases & Descriptions:

bronchiolitis obliterans 6 30 8 32 43 obliterative bronchiolitis 6 30 bronchiolitis fibrosa obliterans (disorder) 6

bronchiolitis, exudative 43 bronchiolitis exudativa 6

Diseases related to bronchiolitis obliterans by text searches and GeneDecks gene sharing:

(show top 50)    (show all 774)

id	Related Disease	Score	Top Affiliating Genes
1	bronchiolitis obliterans organizing pneumonia	35.8	PIK3C2A, UNC119, CHKA, FHOD1, MAPKAP1, IFNA2
2	arthritis	28.3	IL17A, IL1B, IL6, IL8, TNF, TIMP1
3	polymyositis	28.1	PIK3C2A, SFTPD, CHKA, CHKB, GZMB, IL17A
4	myasthenia gravis	24.7	CHKB, MMP9, GZMB, IL10, IL17A, IL6
5	pemphigus	24.3	MMP9, IL10, IL1B, IL1RN, IL6, CCL17
6	measles	23.9	SFTPD, IL10, IL13, IL1B, IL1RN, IL6
7	bronchiolitis	23.4	PIK3C2A, KIR2DS5, KIR3DL1, SFTPA1, SFTPD, BMP6
8	pneumonia	21.2	PIK3C2A, SFTPA1, SFTPD, BMP6, SCGB1A1, CHKA
9	leukemia	16.8	PIK3C2A, KIR2DS5, KIR3DL1, SFTPD, BMP6, SCGB1A1
10	chronic ulcer of skin	13.8	MMP8, PDGFB, DEFB4A
11	allergic contact dermatitis of eyelid	13.7	IL17A, CXCL10, CXCR3
12	lymphomatoid papulosis	13.7	GZMB, CCL17, TNFRSF8, CXCR3
13	slow-channel congenital myasthenic syndrome	13.7	IL8, CRP
14	paragonimiasis	13.6	CCL17, RNASE3, CXCR3
15	common cold	13.6	IL8, IFNA2, ALB, RNASE3
16	creatine phosphokinase	13.6	PIK3C2A, CHKA, CHKB, SLPI
17	hypocalcemia	13.6	PIK3C2A, CHKA, CHKB, ALB, SLPI
18	chronic rapidly progressive glomerulonephritis	13.6	SCGB1A1, ALB, SLPI
19	eosinophilic gastroenteritis	13.6	ALB, SRF, RNASE3
20	cardiac rupture	13.5	CHKB, MMP9, CRP
21	glycogen storage disease	13.5	BMP6, CHKB, IL8, ALB, CRP
22	hypophosphatemia	13.5	ALB, SRF, CRP, SLPI
23	peripheral t-cell lymphoma	13.5	GZMB, TNFRSF8, LTA, CXCR3
24	follicular dendritic cell sarcoma	13.5	EVPL, PPL, DSG3
25	galactosemia	13.5	PIK3C2A, CHKB, ALB, SLPI
26	pericardial effusion	13.5	PIK3C2A, CHKB, MUC1, ALB
27	pure red-cell aplasia	13.5	PIK3C2A, GZMB, ALB, TIMP1
28	reticulosarcoma	13.4	MUC1, GZMB, TNFRSF8, CXCR3
29	eosinophilic pneumonia	13.4	IL13, CCL17, RNASE3
30	viral meningitis	13.4	IL6, CRP, CXCR3
31	ulceration of vulva	13.4	MMP8, SRF, RNASE3, PDGFB, HBEGF, DEFB4A
32	neuroleptic malignant syndrome	13.4	PIK3C2A, CHKA, CHKB
33	rheumatoid arthritis	13.4	IL1RN, SRF, CRP, LTA
34	respiratory failure	13.4	SFTPD, SCGB1A1, IL13, CCL17, RNASE3, CXCL10
35	chronic sphenoidal sinusitis	13.4	IL13, IL8, RNASE3
36	vogt-koyanagi-harada disease	13.4	KIR2DS5, KIR3DL1, IL17A, IFNA2, IFNG
37	allergic rhinitis	13.3	IL13, IL8, RNASE3
38	muckle-wells syndrome	13.3	IL1B, IL8, CRP
39	hypereosinophilic syndrome	13.3	IL13, IFNA2, SRF, RNASE3
40	legionnaires' disease	13.3	PIK3C2A, ALB, CRP, TLR4, TLR5, CXCL10
41	lacrimal duct obstruction	13.3	HMOX1, RNASE3, LTA, HBEGF, CXCL10
42	middle ear cholesteatoma	13.3	CHKB, MMP9, DEFB4A
43	chronic eosinophilic pneumonia	13.3	IL10, RNASE3, CXCR3
44	psoriatic arthritis	13.3	NOD2, LTA
45	capillary leak syndrome	13.3	IL6, IL8, ALB
46	hepatitis e	13.3	IFNA2, IFNG, ALB, PDGFB
47	adult t-cell leukemia	13.3	GZMB, IFNA2, TNFRSF8, CXCL10, CXCR3
48	vascular disease	13.3	BMP6, MMP9, LOX, HMOX1, CRP, PDGFB
49	bronchitis	13.3	CHKB, IL17A, SRF, NOD2
50	lipoid nephrosis	13.3	IL10, IL13, ALB

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to bronchiolitis obliterans:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Lung -> Respiratory Bronchioles -> Cilliated Cells	Potential therapeutic candidate, affected by disease

MGI Mouse Phenotypes related to bronchiolitis obliterans:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.4	PDGFB, SRF, SCGB1A1, SFTPD
2	renal/urinary system phenotype	MP:0005367	10.3	TLR8, TLR7, PDGFB, SCGB1A1
3	hematopoietic system phenotype	MP:0005397	9.5	PRDX2, DSG3, TLR9, TLR8, TLR7, TLR5
4	skeleton phenotype	MP:0005390	9.2	HBEGF, NOD2, SRF, IL6, IL17A, MMP9
5	endocrine/exocrine gland phenotype	MP:0005379	9.0	IFNG, LTA, TLR2, TLR3
6	liver/biliary system phenotype	MP:0005370	8.6	TLR5, TLR4, TLR2, IFNG, IL6, CHKA
7	growth/size phenotype	MP:0005378	8.4	DSG3, TLR5, TLR4, HBEGF, LTA, PDGFB
8	integument phenotype	MP:0010771	8.0	DSG3, TLR4, TLR2, HBEGF, EVPL, IFNG
9	digestive/alimentary phenotype	MP:0005381	7.7	NOD2, TLR2, DSG3, TGFB1, IFNG, IL23A
10	immune system phenotype	MP:0005387	7.3	TLR3, NOD2, SRF, TNFRSF8, TNF, CABIN1
11	muscle phenotype	MP:0005369	7.0	TGFB1, TLR3, TLR2, HBEGF, PDGFB, SRF
12	mortality/aging	MP:0010768	6.3	SRF, NOD2, LTA, HBEGF, TLR2, TLR4
13	homeostasis/metabolism phenotype	MP:0005376	6.2	TLR9, TLR8, TLR7, TLR5, TLR4, TLR2
14	vision/eye phenotype	MP:0005391	5.9	PDGFB, LTA, TLR4, DSG3, TGFB1, TNF
15	reproductive system phenotype	MP:0005389	5.5	PDGFB, TLR3, TLR4, TIMP1, TGFB1, TNF
16	tumorigenesis	MP:0002006	5.2	IFNG, TNF, TLR2, TLR3, TLR4, TIMP1
17	cardiovascular system phenotype	MP:0005385	4.5	LTA, HBEGF, TLR2, TLR3, TLR4, TLR5
18	cellular phenotype	MP:0005384	4.5	TLR5, TLR4, TLR2, LTA, NOD2, TLR9

Articles related to bronchiolitis obliterans:

(show all 48)

id	Title	Authors	Year	Affiliating Genes
1	Clara cell secretory protein and surfactant protein-D do not predict bronchiolitis obliterans syndrome after lung transplantation. (20683434)	Paantjens A.W.... van de Graaf E.A.	2010	SFTPD, SCGB1A1
2	Tolerability of pravastatin in pediatric hematopoieti c stem cell transplant patients with bronchiolitis obliterans. (20186101)	Duncan C.N.... Lehmann L.E.	2010	CHKB
3	Polymorphisms in innate immunity genes associated wit h development of bronchiolitis obliterans after lung transplantation. (20227302)	Kastelijn E.A.... van den Bosch J.M.	2010	TLR3, TLR1, TLR2
4	Serum KL-6 level and the development of bronchiolitis obliterans syndrome in lung transplant recipients. (20667031)	Haberman B.... Elidemir O.	2010	MUC1
5	Genetic polymorphisms in MMP7 and reduced serum level s associate with the development of bronchiolitis obliterans syndrome after lun g transplantation. (20347338)	Kastelijn E.A.... van den Bosch J.M.	2010	MMP7
6	Increased net gelatinase but not serine protease acti vity in bronchiolitis obliterans syndrome. (20417130)	Riise G.C.... LindAcn A.	2010	MMP9
7	Circulating and intrapulmonary C-reactive protein: a predictor of bronchiolitis obliterans syndrome and pulmonary allograft outcome. (19632576)	Vos R.... Verleden G.M.	2009	IL8
8	Increased levels of T cell granzyme b in bronchioliti s obliterans syndrome are not suppressed adequately by current immunosuppressiv e regimens. (19737140)	Hodge S.... Holmes M.	2009	GZMB
9	Plasma C-reactive protein levels correlate with markers of airway inflammation after lung transplantation: a role for systemic inflammation in bronchiolitis obliterans syndrome? (19328934)	Vos R.... Verleden G.M.	2009	CRP
10	A dichotomy in bronchiolitis obliterans syndrome afte r lung transplantation revealed by azithromycin therapy. (18827151)	Vanaudenaerde B.M.... Verleden G.M.	2008	IL8
11	The role of the IL23/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation. (18786233)	Vanaudenaerde B.M.... Verleden G.M.	2008	IL17A, IL23A
12	Soluble CD30 measured after lung transplantation does not predict bronchiolitis obliterans syndrome in a tacrolimus/mycophenolate mofetil-based immunosuppressive regimen. (18926413)	Kwakkel-van Erp J.M.... van de Graaf E.A.	2008	TNFRSF8
13	Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation. (18158963)	Hildebrandt G.C.... Holler E.	2008	NOD2
14	Attenuation of airway obliteration by ciprofloxacin in experimental posttransplant bronchiolitis obliterans. (18337667)	Remund K.... Boehler A.	2008	TNF, IFNG, BMP6
15	Soluble CD30 levels as a diagnostic marker for bronchiolitis obliterans syndrome following human lung transplantation. (18047935)	Golocheikine A.S.... Mohanakumar T.	2008	TNFRSF8
16	The killer immunoglobulin-like receptor (KIR) group A haplotype is associated with bronchiolitis obliterans syndrome after lung transplantation. (18765192)	Kwakkel-van Erp J.M.... Otten H.G.	2008	KIR3DL1, KIR2DS5
17	Serum thymus and activation regulated chemokine levels post-lung transplantation as a predictor for the bronchiolitis obliterans syndrome. (18785972)	Paantjens A.W.... Otten H.G.	2008	CCL17
18	Prognostic value of serum surfactant protein D level prior to transplant for the development of bronchiolitis obliterans syndrome and idiopathic pneumonia syndrome following allogeneic hematopoietic stem cell transplantation. (18347569)	Nakane T.... Hino M.	2008	SFTPD
19	Bronchoalveolar cellularity and interleukin-8 levels in measles bronchiolitis obliterans. (17494793)	Koh Y.Y.... Kim C.K.	2007	IL8
20	Bronchoalveolar lavage fluid proteome in bronchiolitis obliterans syndrome: possible role for surfactant protein A in disease onset. (18022079)	Meloni F.... Fietta A.M.	2007	PRDX2, SFTPA1
21	IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. (17182591)	Keane M.P.... Belperio J.A.	2007	IL13
22	Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome. (16741151)	Verleden G.M.... Van Raemdonck D.E.	2006	IL8
23	Cytokine gene polymorphisms are not associated with bronchiolitis obliterans syndrome or survival after lung transplant. (17097497)	Snyder L.D.... Palmer S.M.	2006	TGFB1, TNF, IL6
24	Serum KL-6 as a marker for bronchiolitis obliterans syndrome after lung transplantation. (16969297)	Walter J.N.... Elidemir O.	2006	MUC1
25	Matrix metalloproteinase-9 in bronchiolitis obliteran s syndrome after lung transplantation. (15738294)	HA1bner R.H.... Bewig B.	2005	MMP9
26	Decreased serum levels of clara cell secretory protein (CC16) are associated with bronchiolitis obliterans and may permit early diagnosis in patients after allogeneic stem-cell transplantation. (15912112)	Mattsson J.... Nord M.	2005	SCGB1A1
27	Broncho-alveolar lavage matrix metalloproteases as a sensitive measure of bronchiolitis obliterans. (15888067)	Taghavi S.... Aharinejad S.	2005	MMP8, MMP9, TIMP1
28	Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantation. (15502724)	Ross D.J.... Ganz T.	2004	DEFB4A
29	Bronchoalveolar lavage cytokine profile in a cohort of lung transplant recipients: a predictive role of interleukin-12 with respect to onset of bronchiolitis obliterans syndrome. (15454171)	Meloni F.... ViganA^ M.	2004	IL8, BMP6
30	Heme oxygenase-1 expression in alveolar macrophages is elevated in patients with bronchiolitis obliterans syndrome after lung transplantation. (15477118)	Slebos D.J.... Postma D.S.	2004	HMOX1
31	A case of loxoprofen sodium-induced bronchiolitis obliterans organizing pneumonia (BOOP) (14727549)	Fujita K.... Suga M.	2003	CRP
32	Interleukin-17 stimulates release of interleukin-8 by human airway smooth muscle cells in vitro: a potential role for interleukin-17 and airway smooth muscle cells in bronchiolitis obliterans syndrome. (14585390)	Vanaudenaerde B.M.... Verleden G.M.	2003	IL8, IL17A
33	Interleukin-6 and interferon-gamma gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation. (12451269)	Lu K.C.... Mohanakumar T.	2002	TGFB1, TNF, IL6
34	Decreased serum and bronchoalveolar lavage levels of Clara cell secretory protein (CC16) is associated with bronchiolitis obliterans syndrome and airway neutrophilia in lung transplant recipients. (11981419)	Nord M.... Riise G.C.	2002	SCGB1A1
35	Interleukin-1 receptor antagonist as a biomarker for bronchiolitis obliterans syndrome in lung transplant recipients. (11889437)	Belperio J.A.... Strieter R.M.	2002	TNF, IL1B, IL10
36	Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. (12097412)	Belperio J.A.... Strieter R.M.	2002	CXCR3
37	Activation of human airway epithelial cells by non-HLA antibodies developed after lung transplantation: a potential etiological factor for bronchiolitis obliterans syndrome. (11349733)	Jaramillo A.... Mohanakumar T.	2001	BMP6, HBEGF
38	Constrictive bronchiolitis obliterans. Characterisation of fibrogenesis and lysyl oxidase expression patterns. (11499844)	Streichenberger N.... Cordier J.F.	2001	LOX
39	Bronchiolitis obliterans organizing pneumonia in a patient with chronic myelogenous leukemia developing after initiation of interferon and cytosine arabinoside. (11872080)	Patel M.... Lowsky R.	2001	IFNA2
40	Severe hypoxemia with orthodeoxia due to right to left shunt in idiopathic bronchiolitis obliterans organizing pneumonia (10756564)	Naccache J.M.... Cordier J.F.	2000	ALB
41	On interleukin-8, neutrophil activation, and bronchiolitis obliterans syndrome in lung transplantation. (10933146)	Riise G.C.	2000	IL8
42	Elevated levels of interleukin-8 and transforming growth factor-beta in bronchoalveolar lavage fluid from patients with bronchiolitis obliterans syndrome: proinflammatory role of bronchial epithelial cells. Munich Lung Transplant Group. (10933164)	Elssner A.... Vogelmeier C.	2000	TNF, IL8, IL10
43	Bronchiolitis obliterans syndrome after (heart-)lung transplantation. Impaired antiprotease defense and increased oxidant activity. (10556134)	Hirsch J.... Vogelmeier C.	1999	SLPI
44	Persistent high BAL fluid granulocyte activation marker levels as early indicators of bronchiolitis obliterans after lung transplant. (10596701)	Riise G.C.... ScherstAcn H.	1999	RNASE3
45	Paraneoplastic pemphigus associated with Castleman tumor, myasthenia gravis and bronchiolitis obliterans. (10459112)	Chorzelski T.... Jablonska S.	1999	PPL, DSG3, EVPL
46	Bronchiolitis obliterans organizing pneumonia as the first manifestation of polymyositis. (9042178)	Fata F.... Herzlich B.C.	1997	CHKA, MAPKAP1
47	Bronchiolitis obliterans: the lone manifestation of r heumatoid arthritis? (8005266)	Schwarz M.I.... Tuder R.	1994	SRF
48	A case of bronchiolitis obliterans organizing pneumonia with positive anti Jo-1 antibody preceding polymyositis (1630059)	Imokawa S.... Chida K.	1992	PIK3C2A

Genes related to bronchiolitis obliterans according to GeneCards:

(show top 50)    (show all 65)

id	Symbol	Description	Score	GeneCards Section Context
1	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
2	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
3	CHKA	choline kinase alpha	11.0	Publications
4	MAPKAP1	mitogen-activated protein kinase associated protein 1	11.0	Publications
5	IL17A	interleukin 17A	11.0	Publications
6	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
7	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
8	PDGFB	platelet-derived growth factor beta polypeptide	11.0
9	BMP6	bone morphogenetic protein 6	11.0	Publications
10	IFNA2	interferon, alpha 2	11.0	Publications
11	CXCL10	chemokine (C-X-C motif) ligand 10	11.0
12	IL8	interleukin 8	11.0	Publications
13	CRP	C-reactive protein, pentraxin-related	11.0	Publications
14	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
15	ALB	albumin	11.0	Publications
16	KIR2DS5	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5	11.0	Publications
17	EVPL	envoplakin	11.0	Publications
18	OAZ1	ornithine decarboxylase antizyme 1	11.0
19	UNC119	unc-119 homolog (C. elegans)	11.0
20	TLR8	toll-like receptor 8	11.0	Publications
21	TLR10	toll-like receptor 10	11.0	Publications
22	GOSR2	golgi SNAP receptor complex member 2	11.0
23	TLR1	toll-like receptor 1	11.0	Publications
24	SFTPD	surfactant protein D	11.0	Publications
25	PRDX2	peroxiredoxin 2	11.0	Publications
26	SFTPA1	surfactant protein A1	11.0	Publications
27	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
28	IL23A	interleukin 23, alpha subunit p19	11.0	Publications
29	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0	Publications
30	ZNF33A	zinc finger protein 33A	11.0	Disorders
31	HBEGF	heparin-binding EGF-like growth factor	11.0	Publications
32	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
33	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
34	PPL	periplakin	11.0	Publications
35	DEFB4A	defensin, beta 4A	11.0	Publications
36	DSG3	desmoglein 3	11.0	Publications
37	TLR9	toll-like receptor 9	11.0	Publications
38	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
39	SRF	serum response factor (c-fos serum response element-binding transcription factor)	11.0	Publications
40	TLR3	toll-like receptor 3	11.0	Publications
41	TLR5	toll-like receptor 5	11.0	Publications
42	KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	11.0	Publications
43	LOX	lysyl oxidase	11.0	Publications
44	TLR7	toll-like receptor 7	11.0	Publications
45	TLR6	toll-like receptor 6	11.0	Publications
46	FHOD1	formin homology 2 domain containing 1	11.0
47	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
48	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
49	TUBA1B	tubulin, alpha 1b	11.0
50	CHKB	choline kinase beta	11.0	Publications

Pathways related to bronchiolitis obliterans according to GeneDecks:

(show top 50)    (show all 95)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.3	CCL17, IL23A, LTA
2	NFAT Signaling and Lymphocyte Interactions36	9.9	BMP6, IL13, IL23A, CCL17
3	Bacterial infections in CF airways41	9.8	SFTPA1, SFTPD, MUC1, TLR1, TLR2, TLR5
4	IL-6 Pathway36	9.7	BMP6, CXCL10, TIMP1, IL23A, IL10, IL8
5	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	9.7	IL6, TLR1, TLR5, TLR6, TLR7, TLR8
6	Toll-Like Receptors Pathway36	9.3	TLR9, TLR1, TLR10, TLR2, TLR4, TLR5
7	Phagocytosis of Microbes36	9.3	TLR9, TLR1, TLR10, TLR2, TLR3, TLR4
8	Immune response_Bacterial infections in normal airways41	9.2	TLR1, IFNG, TLR5, DEFB4A, IL1B
9	Inflammasome Activation Pathways37	8.9	TLR2, TLR7, TLR8, TLR9, TLR6, TLR5
10	TREM1 Pathway36	8.9	TLR5, TLR6, IL1B, TLR4, TLR3, TLR8
11	Immune response_TLR signaling pathways41	8.8	SFTPA1, IL6, IL8, TLR1, TLR2, TLR4
12	Akt Signaling36	8.7	TNFRSF8, PDGFB, LTA, CXCL10, CXCR3, IL6
13	Endothelin-1 Signaling Pathway36	8.6	CXCL10, IL1B, CCL17, IL6, IL23A, IL13
14	Amoebiasis20	8.6	IL1B, IL6, IL8, TLR2, TLR4, TGFB1
15	NF-kappaB Signaling3	8.4	TLR9, TLR2, TLR3, TNF, IL1B, TLR4
16	Toll-Like Receptor Signaling Pathways37	8.3	IL1B, IL6, TLR1, TLR10, TLR2, TLR3
17	Pertussis20	8.3	TNF, IL8, IL6, IL23A, IL10, SFTPA1
18	IL-10 Pathway36	8.1	IL6, IL1B, IL10, HMOX1, TNF, TLR4
19	Molecular Mechanisms of Cancer36	8.1	IL6, PDGFB, LTA, TIMP1, TNFRSF8, CCL17
20	TRAF Pathway36	8.1	TLR1, TLR10, TLR2, TLR3, TLR4, TLR5
21	all-trans-Retinoic Acid Signaling in Brain36	8.0	IL10, BMP6, CCL17, IL13, TNF, CXCL10
22	PEDF Induced Signaling36	7.9	SRF, LTA, CXCL10, TNF, IL8, IL6
23	Rho Family GTPases36	7.9	CCL17, IL8, CXCL10, TGFB1, LTA, IL23A
24	STAT3 Pathway36	7.8	BMP6, IL10, IL1B, CCL17, IL23A, IL6
25	MIF Mediated Glucocorticoid Regulation36	7.8	CCL17, IL13, LTA, TLR4, CXCL10, IL8
26	MIF Regulation of Innate Immune Cells36	7.8	IL10, BMP6, IL13, IL1B, IL23A, IL6
27	Toll-like receptor signaling pathway20	7.7	CXCL10, TLR9, TLR8, TLR7, TLR6, TLR5
28	Influenza A20	7.6	CXCL10, TLR7, TLR3, TNF, IFNG, IFNA2
29	Th17 Differentiation37	7.6	IL17A, IL1B, IL23A, IL6, TLR1, TLR10
30	Measles20	7.6	IL6, IL1B, IFNG, IL13, TLR4, TLR9
31	TGF-Beta Pathway36	7.5	BMP6, TIMP1, TGFB1, PDGFB, CCL17, IL8
32	ERK Signaling36	7.5	BMP6, IL6, TIMP1, PDGFB, SRF, CCL17
33	Cytokine Network36	7.5	IL6, LTA, IL10, IL13, TNF, IFNG
34	Th1 Differentiation37	7.3	TLR1, TLR2, TLR3, TLR4, TLR5, TLR6
35	African trypanosomiasis20	7.3	IL1B, IL10, IL6, TLR9, IFNG, TNF
36	Rheumatoid arthritis20	7.1	IL17A, TNF, IL1B, IL23A, IL6, IL8
37	MAPK Family Pathway36	6.9	LTA, TNF, IL1B, TGFB1, TIMP1, IL8
38	PAK Pathway36	6.9	IL1B, IL8, IL6, IL23A, IL13, IL10
39	JAK-STAT Pathway36	6.8	IFNA2, IL8, IL6, IL23A, IL1B, IL13
40	Malaria20	6.8	IFNG, TNF, TLR2, IL6, TLR9, TGFB1
41	Antioxidant Action of Vitamin-C36	6.8	IL1B, BMP6, IL13, IL23A, IL6, IL8
42	p38 Signaling36	6.8	IL10, IL13, IL1B, IL23A, IL6, CXCR3
43	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	6.7	TLR7, TLR9, TGFB1, TLR6, TLR5, TLR4
44	Chagas disease (American trypanosomiasis)20	6.6	TLR2, IL10, IL6, IL8, IFNG, TGFB1
45	Tec Kinases Signaling36	6.6	CXCR3, TLR3, TLR4, TLR5, TLR6, TLR7
46	NF-KappaB (p50-p65) Pathway36	6.5	TIMP1, TLR10, TLR1, LTA, PDGFB, TNF
47	NF-KappaB Family Pathway36	6.5	LTA, TLR10, TLR2, TLR3, TLR4, TLR5
48	Colorectal Cancer Metastasis36	6.4	TLR5, TLR4, TLR3, TLR2, TLR10, TLR1
49	Cytokine-cytokine receptor interaction20	6.4	IL13, IL17A, IL1B, IL23A, IL6, IL8
50	Tuberculosis20	6.3	TGFB1, TLR9, IL10, IL1B, IL23A, IL6

Compounds related to bronchiolitis obliterans according to GeneDecks:

(show top 50)    (show all 273)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.4	DSG3, LTA, CRP, PIK3C2A
2	hyaluronic acid32 18	10.4	BMP6, SCGB1A1, MUC1, SLPI, LTA, RNASE3
3	endotoxin32	9.4	SFTPD, SCGB1A1, CHKB, SLPI, CXCR3, CXCL10
4	pge232	9.2	TLR2, HMOX1, LOX, IL23A, IL1RN, IL17A
5	calcitriol32 42 9 18 9	13.1	ALB, LTA, BMP6, IL13, TLR2, TIMP1
6	flagellin32	8.9	TLR9, TLR6, TLR5, TLR4, TLR3, TLR2
7	h2o232	8.9	PRDX2, RNASE3, MMP8, IL13, IL1RN, LOX
8	estrogen32	8.6	CXCL10, DEFB4A, TIMP1, HBEGF, PDGFB, RNASE3
9	oxygen32 18	9.5	GZMB, MMP8, MMP7, CHKB, CHKA, SCGB1A1
10	creatinine32	8.4	SLPI, CXCR3, CXCL10, PRDX2, BMP6, TGFB1
11	histamine32 18	9.2	SLPI, CXCR3, CXCL10, DEFB4A, TIMP1, TLR4
12	fibrinogen32	8.1	SLPI, TLR4, TLR2, HBEGF, CRP, RNASE3
13	polyinosinic-polycytidylic acid32	8.0	IL10, CXCL10, TLR9, TLR7, TLR4, TLR3
14	tgf beta132	7.8	HBEGF, LTA, TNF, IL6, IL1RN, IL13
15	cysteine32	7.8	SLPI, PRDX2, TIMP1, HMOX1, ALB, IFNG
16	imiquimod32 42 9 9	10.8	BMP6, TLR8, TLR7, TLR4, TLR3, TNF
17	atorvastatin32 34 9 18 9	11.7	IL6, IL1RN, IL10, MMP9, CHKB, CHKA
18	sb 20358032 42	8.7	CRP, TNF, HMOX1, IFNG, IL6, IL17A
19	superoxide32 18	8.6	SLPI, CXCR3, PRDX2, TLR4, TLR2, SRF
20	poly(i-c)32	7.2	TLR8, TLR7, TLR5, TLR4, TLR3, TLR2
21	leukotriene b432 42 18	9.2	SLPI, CXCL10, IL1RN, RNASE3, MMP9, TLR2
22	etanercept32 9 9	9.0	CXCR3, TIMP1, LTA, CRP, TNF, IFNG
23	simvastatin32 34 42 9 18 9	12.0	IL8, IL6, IL1RN, IL10, MMP9, CHKB
24	neopterin32	6.9	CXCL10, LTA, CRP, SRF, TNF, IFNG
25	lipoteichoic acid32	6.9	IL6, IL1RN, IL1B, IL10, IL8, TNF
26	hydrocortisone32 9 9	8.8	MUC1, BMP6, SLPI, CXCR3, CXCL10, TNF
27	ccl332	6.6	CXCR3, MMP9, IL10, IL13, CXCL10, TLR9
28	polymyxin b32	6.6	IFNG, TNF, IL8, IL6, IL1RN, IL1B
29	alanine32	6.6	CRP, SRF, HMOX1, ALB, IFNA2, IL6
30	prednisolone32 9 9	8.6	IL10, GZMB, CHKB, BMP6, SFTPD, PIK3C2A
31	peptidoglycan32	6.5	TLR2, TLR1, NOD2, SRF, TNF, IL8
32	infliximab32 9 9	8.5	TIMP1, TLR4, LTA, NOD2, CRP, TNF
33	ly29400232	6.5	IL1B, IL17A, IL13, IL10, GZMB, MMP9
34	methotrexate32 34 42 9 9	10.4	IL6, IL1RN, IL1B, IL17A, IL10, MMP9
35	tacrolimus32 34 9 9	9.4	TNF, CABIN1, IFNG, CCL17, IL17A, IL13
36	vegf32	6.3	SLPI, TGFB1, IL1RN, TIMP1, HBEGF, CHKB
37	lipid32	6.1	LOX, PIK3C2A, KIR3DL1, IL6, IL23A, IL1RN
38	lactate32	5.9	SLPI, TGFB1, TIMP1, TLR4, LTA, RNASE3
39	indomethacin32 9 9	7.8	IL13, TGFB1, TIMP1, LTA, ALB, IL1B
40	il 1032	5.7	TLR4, TLR2, LTA, NOD2, TNF, IFNG
41	actinomycin d32	5.4	TGFB1, MMP9, MUC1, IL13, IL17A, IL1B
42	rantes32	5.3	SLPI, CXCR3, CXCL10, DEFB4A, TGFB1, TIMP1
43	thymidine32 18	6.3	PDGFB, SLPI, CXCR3, CXCL10, TGFB1, CHKA
44	tyrosine32	5.3	TLR9, TLR5, TLR4, TLR3, TLR2, HBEGF
45	serine32	5.2	GZMB, MMP9, MMP8, MMP7, MUC1, CHKA
46	cycloheximide32	4.4	HMOX1, IFNG, LOX, IL8, IL6, IL1RN
47	cyclosporin a32 42	5.2	TNF, BMP6, PIK3C2A, CHKB, MMP8, MMP9
48	retinoic acid32 42 18	5.5	LTA, RNASE3, SRF, TNF, TUBA1B, HMOX1
49	nitric oxide32 9 18 9	6.0	TUBA1B, GZMB, MMP8, MMP7, MUC1, CHKB
50	dexamethasone32 42 34 9 9	6.9	SLPI, CXCR3, CXCL10, TUBA1B, HMOX1, IFNG

Cellular components related to bronchiolitis obliterans according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endolysosome membrane	GO:036020	10.1	TLR9, TLR8, TLR7, TLR3
2	Toll-like receptor 2-Toll-like receptor 6 protein complex	GO:035355	10.0	TLR2, TLR6
3	Toll-like receptor 1-Toll-like receptor 2 protein complex	GO:035354	9.8	TLR1, TLR2
4	platelet alpha granule lumen	GO:031093	9.4	TGFB1, TIMP1, PDGFB, ALB
5	cell surface	GO:009986	8.5	TGFB1, TLR3, TLR2, HBEGF, PDGFB, NOD2
6	external side of plasma membrane	GO:009897	8.2	CXCR3, CXCL10, TLR4, TLR2, TNF, IFNG
7	extracellular region	GO:005576	5.3	PDGFB, RNASE3, CRP, ALB, HBEGF, TLR9
8	extracellular space	GO:005615	4.9	SFTPA1, LOX, IFNA2, IFNG, ALB, HMOX1

Biological processes related to bronchiolitis obliterans according to GeneDecks:

(show top 50)    (show all 76)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of interferon-alpha biosynthetic process	GO:045356	10.3	TLR7, TLR3, TLR8, TLR9
2	positive regulation of interferon-gamma biosynthetic process	GO:045078	10.2	TLR3, TLR7, TLR8, TLR9
3	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response	GO:052033	10.2	TLR3, TLR1, TLR4, TLR7
4	microglial cell activation involved in immune response	GO:002282	10.2	TLR3, TLR1, TLR7, TLR4
5	positive regulation of toll-like receptor signaling pathway	GO:034123	10.2	TLR9, TLR5, TLR3, TLR2
6	positive regulation of interferon-beta biosynthetic process	GO:045359	10.1	TLR4, TLR7, TLR8, TLR9, TLR3
7	positive regulation of tumor necrosis factor biosynthetic process	GO:042535	10.1	TNFRSF8, TLR2, TLR1, TLR4
8	positive regulation of nitric-oxide synthase biosynthetic process	GO:051770	10.0	TLR4, TLR2, NOD2, TLR9
9	positive regulation of interleukin-10 production	GO:032733	9.9	NOD2, IL23A, TLR4, TLR9
10	I-kappaB phosphorylation	GO:007252	9.9	TLR2, TLR3, TLR9, TLR4, TLR7
11	positive regulation of interleukin-8 biosynthetic process	GO:045416	9.8	TLR4, TLR8, TLR7, TNF
12	positive regulation of inflammatory response	GO:050729	9.8	TLR3, TLR7, TLR4, TLR9, TLR2, IL23A
13	positive regulation of interferon-beta production	GO:032728	9.7	TLR9, TLR4, TLR2, TLR3
14	defense response to Gram-negative bacterium	GO:050829	9.7	TLR4, IL23A, MMP7, IL6
15	extracellular matrix disassembly	GO:022617	9.6	MMP9, MMP8, MMP7, TIMP1
16	MyD88-dependent toll-like receptor signaling pathway	GO:002755	9.6	TLR6, TLR5, NOD2, TLR4, TLR2, TLR10
17	chronic inflammatory response to antigenic stimulus	GO:002439	9.5	TNF, IL1RN, IL1B
18	negative regulation of interleukin-6 production	GO:032715	9.4	TNF, TLR4, TLR9, IL10
19	negative regulation of lipid storage	GO:010888	9.4	TNF, CRP, IL6
20	positive regulation of JUN kinase activity	GO:043507	9.3	IL1B, IL1RN, TLR9, TLR6
21	positive regulation of interleukin-8 production	GO:032757	9.3	TLR9, TLR7, TLR5, TLR3, TLR2, IL1B
22	positive regulation of interleukin-6 biosynthetic process	GO:045410	9.3	IFNG, TLR1, TLR6, IL1B
23	positive regulation of smooth muscle cell proliferation	GO:048661	9.3	HMOX1, HBEGF, PDGFB, IL13, IL6, TNF
24	cellular response to mechanical stimulus	GO:071260	9.2	TLR7, TLR5, IL1B, TLR8, TLR4, TLR3
25	positive regulation of interferon-gamma production	GO:032729	9.2	IL1B, TNF, IL23A, TLR4, LTA
26	positive regulation of osteoclast differentiation	GO:045672	9.2	TNF, IL23A, IL17A, IFNG
27	positive regulation of interleukin-12 production	GO:032735	9.2	TLR4, TLR9, TLR2, IL23A, IFNG, TLR3
28	positive regulation of JNK cascade	GO:046330	9.1	TLR9, TLR4, TLR3, NOD2, TNF, IL1B
29	defense response to Gram-positive bacterium	GO:050830	9.1	TLR2, MMP7, IL6, LTA, TNF
30	negative regulation of T cell proliferation	GO:042130	9.0	IL10, SCGB1A1, SFTPD, TGFB1
31	defense response to virus	GO:051607	9.0	IFNG, TLR3, CXCL10, TLR8, TLR7, IL6
32	positive regulation of tumor necrosis factor production	GO:032760	9.0	TLR3, NOD2, TLR4, TLR9, IL23A, IFNG
33	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	8.9	TNF, IFNG, IL1B
34	cell-cell signaling	GO:007267	8.9	IL1B, IL13, IL17A, IL10, CCL17, IFNA2
35	positive regulation of chemokine production	GO:032722	8.9	TNF, TLR3, TLR9, TLR7, TLR2, IL6
36	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	8.9	TLR3, IL1B, HMOX1, NOD2, TLR9, TLR6
37	positive regulation of chemokine biosynthetic process	GO:045080	8.9	IL1B, IFNG, HMOX1, TNF, TLR3
38	positive regulation of NF-kappaB import into nucleus	GO:042346	8.9	IL23A, TNF, TLR2, TLR3, TLR4, TLR7
39	innate immune response	GO:045087	8.8	TLR8, TLR6, TLR5, TLR4, TLR3, TLR2
40	immune response	GO:006955	8.8	CCL17, IL8, TLR10, TLR1, TLR2, TLR4
41	lipopolysaccharide-mediated signaling pathway	GO:031663	8.7	TLR4, TLR2, TGFB1, IL1B, TNF
42	negative regulation of growth of symbiont in host	GO:044130	8.6	LTA, TLR2, IFNG, IL10, TNF
43	positive regulation of nitric oxide biosynthetic process	GO:045429	8.5	IL1B, TLR2, TNF, IFNG, TLR4
44	defense response to bacterium	GO:042742	8.4	TLR9, TLR6, TLR4, DEFB4A, TLR3, NOD2
45	positive regulation of interleukin-6 production	GO:032755	8.2	TLR4, TLR2, TLR3, TLR7, TLR9, NOD2
46	response to hypoxia	GO:001666	8.2	MMP9, TLR4, PDGFB, TGFB1, CRP, SRF
47	positive regulation of NF-kappaB transcription factor activity	GO:051092	7.7	TLR3, TLR2, NOD2, TNF, IL6, TNFRSF8
48	response to drug	GO:042493	7.3	LOX, IFNG, TGFB1, LTA, PDGFB, IL1RN
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.6	TLR2, TLR3, TLR4, TLR9, TGFB1, TNF
50	inflammatory response	GO:006954	6.2	TLR7, TLR1, TLR10, CRP, TNF, IFNA2

Molecular functions related to bronchiolitis obliterans according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	diacyl lipopeptide binding	GO:042498	10.0	TLR2, TLR6
2	choline kinase activity	GO:004103	9.9	CHKA, CHKB
3	interleukin-1 receptor binding	GO:005149	9.4	TLR9, TLR5, IL1RN, IL1B
4	transmembrane signaling receptor activity	GO:004888	9.4	TLR6, TLR4, TLR3, TLR2, TLR10, TLR1
5	growth factor activity	GO:008083	8.1	TGFB1, HBEGF, PDGFB, IL6, IL1B, IL10
6	cytokine activity	GO:005125	7.0	BMP6, LTA, TNF, IFNG, IFNA2, IL6