BPD
MCID: BRN056
MIFTS: 55

Bronchopulmonary Dysplasia (BPD) malady

Respiratory, Fetal categories

Summaries for Bronchopulmonary Dysplasia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Bronchopulmonary dysplasia (BPD; formerly chronic lung disease of infancy) is a chronic lung disorder... more...

MalaCards: Bronchopulmonary Dysplasia, also known as BPD, is related to chorioamnionitis and bronchiolitis. An important gene associated with Bronchopulmonary Dysplasia is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are NF-KappaB Family Pathway and FGFR1b ligand binding and activation. The compounds endotoxin and pge2 have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and bone marrow, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Bronchopulmonary Dysplasia

Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 31LifeMap Discovery™, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal
Anatomical: Respiratory


Characteristics (Orphanet epidemiological data):

49
bronchopulmonary dysplasia:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy; Age of death: Normal


Aliases & Descriptions:

bronchopulmonary dysplasia 43 45 49 31 61
bpd 43 49


External Ids:

MESH via Orphanet36 D001997
ICD10 via Orphanet26 P27.1
SNOMED-CT via Orphanet58 67569000
UMLS via Orphanet62 C0006287

Related Diseases for Bronchopulmonary Dysplasia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Bronchopulmonary Dysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 197)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.8ELANE, IL1RN, FLT1, IL8
2bronchiolitis30.2CCL3, IL8, RNASE3
3vascular disease30.2ITGAM, SOD1, ELANE, PLA2G7, GRP
4asthma30.2SCGB1A1, PLA2G7
5atopy30.0RNASE3, SCGB1A1
6cystic fibrosis30.0SCGB1A1, RBP4, ITGAM, FGF7, RNASE3, IL8
7pulmonary disease, chronic obstructive30.0TXN, RNASE3, TIMP1, CCL3, SFTPB, SCGB1A1
8bronchiectasis30.0RNASE3, IL8, ELANE
9borderline personality disorder10.4
10respiratory distress syndrome, infant10.4
11n syndrome10.3
12patent ductus arteriosus10.3
13leukemoid reaction10.3
14wilson-mikity syndrome10.3
15sandhoff disease10.2
16funisitis10.2
17hypoxia10.2
18pulmonary hypertension, neonatal10.2
19pulmonary function10.2
20periventricular leukomalacia10.0
21interstitial emphysema10.0
22pulmonary edema10.0
23neonatal respiratory failure10.0
24toxic pneumonitis10.0
25protein s deficiency10.0
26rickets10.0
27gastroesophageal reflux disease10.0
28bronchopneumonia10.0
29protein c deficiency10.0
30sleep disorder10.0
31tracheal disease10.0
32hypoadrenalism10.0
33leukomalacia10.0
34protein r deficiency10.0
35spontaneous pneumothorax10.0
36lip disease10.0
37infant acute respiratory distress syndrome10.0
38nephritis10.0IL1RN, RBP4, SCGB1A1
39glomerulonephritis10.0RBP4, IL1RN, ELANE, SCGB1A1, PLA2G7
40vasculitis10.0ITGAM, SELL, ELANE
41rhinitis10.0RNASE3, IL8, SCGB1A1
42coronary heart disease10.0ITGAM, PLA2G7
43gastric ulcer10.0FGF7
44acute myocardial infarction10.0TXN, ITGAM
45diabetes mellitus10.0ITGAM, TXN, SELL, PLA2G7, RBP4, SOD1
46malaria10.0RBP4
47hypercholesterolemia10.0RBP4, ITGAM, PLA2G7
48sinusitis10.0RNASE3
49allergic rhinitis10.0RNASE3, SCGB1A1, IL8
50sarcoidosis10.0IL1RN, GRP, ITGAM, TXN, CCL3, SCGB1A1

Graphical network of the top 20 diseases related to Bronchopulmonary Dysplasia:



Diseases related to bronchopulmonary dysplasia

Clinical Features for Bronchopulmonary Dysplasia

Drugs & Therapeutics for Bronchopulmonary Dysplasia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bronchopulmonary Dysplasia

Drug clinical trials:

Search ClinicalTrials for Bronchopulmonary Dysplasia

Search NIH Clinical Center for Bronchopulmonary Dysplasia

Search CenterWatch for Bronchopulmonary Dysplasia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bronchopulmonary Dysplasia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchopulmonary Dysplasia:
PNEUMOSTEM

Genetic Tests for Bronchopulmonary Dysplasia

Anatomical Context for Bronchopulmonary Dysplasia

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Bronchopulmonary Dysplasia:

33
Brain, Lung, Bone marrow, Heart, Colon, Placenta, Monocytes, T cells, B cells, Endothelial, Fetal brain, Fetal lung

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bronchopulmonary Dysplasia:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Bronchopulmonary Dysplasia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Bronchopulmonary Dysplasia

Sources:
51PubMed
See all sources

Articles related to Bronchopulmonary Dysplasia:

(show top 50)    (show all 571)
idTitleAuthorsYear
1
Early Postnatal Additional High-Dose Oral Vitamin A Supplementation versus Placebo for 28 Days for Preventing Bronchopulmonary Dysplasia or Death in Extremely Low Birth Weight Infants. (24434948)
2014
2
Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins. (23933064)
2013
3
Chorioamnionitis and Bronchopulmonary Dysplasia in Evolution. (24210583)
2013
4
Bronchopulmonary dysplasia: a review. (23420126)
2013
5
The utility of sildenafil in pulmonary hypertension: a focus on bronchopulmonary dysplasia. (23625986)
2013
6
Preeclampsia and the risk of bronchopulmonary dysplasia in VLBW infants: a population based study. (24073247)
2013
7
The promise of stem cells in bronchopulmonary dysplasia. (23582961)
2013
8
Progress in understanding the genetics of bronchopulmonary dysplasia. (23582962)
2013
9
Endothelial colony-forming cell conditioned media promote angiogenesis in vitro and prevent pulmonary hypertension in experimental bronchopulmonary dysplasia. (23666751)
2013
10
Bubble nasal CPAP, early surfactant treatment, and rapid extubation are associated with decreased incidence of bronchopulmonary dysplasia in very-low-birth-weight newborns: efficacy and safety considerations. (23106970)
2013
11
Hydrocortisone vs. dexamethasone treatment for bronchopulmonary dysplasia and their effects on general movements in preterm infants. (22289857)
2012
12
Stem cells for bronchopulmonary dysplasia and intraventricular haemorrhage repair in preterm infants. (22633520)
2012
13
The new bronchopulmonary dysplasia. (21169836)
2011
14
Correlation of urinary inflammatory and oxidative stress markers in very low birth weight infants with subsequent development of bronchopulmonary dysplasia. (21651454)
2011
15
Fatty acid-binding proteins and peribronchial angiogenesis in bronchopulmonary dysplasia. (21177979)
2011
16
Severe bronchopulmonary dysplasia improved by noninvasive positive pressure ventilation: a case report. (21896175)
2011
17
Use of azithromycin for the prevention of bronchopulmonary dysplasia in preterm infants: a randomized, double-blind, placebo controlled trial. (20963840)
2011
18
Blood protein concentrations in the first two postnatal weeks that predict bronchopulmonary dysplasia among infants born before the 28th week of gestation. (21150694)
2011
19
Respiratory outcomes and atopy in school-age children who were preterm at birth, with and without bronchopulmonary dysplasia. (21552667)
2011
20
Inhaled nitric oxide and bronchopulmonary dysplasia. (21725058)
2011
21
Association of bronchopulmonary dysplasia and hypercarbia in ventilated infants with birth weights of 500-1,499 g. (21863239)
2011
22
MicroRNA expression profile in hyperoxia-exposed newborn mice during the development of bronchopulmonary dysplasia. (21310116)
2011
23
Bronchopulmonary dysplasia: the challenges for primary care. (21597665)
2011
24
Expression of high mobility group protein-B1 in mice with hyperoxia-induced bronchopulmonary dysplasia]. (20350435)
2010
25
Conductive hearing loss in children with bronchopulmonary dysplasia: a longitudinal follow-up study in children aged between 6 and 24 months. (20554131)
2010
26
Isolation of tracheal aspirate mesenchymal stromal cells predicts bronchopulmonary dysplasia. (20937656)
2010
27
Development of sucking patterns in pre-term infants with bronchopulmonary dysplasia. (20453521)
2010
28
Pulmonary hypertension in preterm infants with bronchopulmonary dysplasia. (20339498)
2010
29
Severe pulmonary arterial hypertension in a very premature baby with bronchopulmonary dysplasia: normalization with long-term sildenafil. (19829144)
2010
30
Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants. (19204058)
2009
31
Placental IL-10 dysregulation and association with bronchopulmonary dysplasia risk. (19581835)
2009
32
Relation of exhaled nitric oxide levels to development of bronchopulmonary dysplasia. (19383857)
2009
33
Nasal CPAP and surfactant for treatment of respiratory distress syndrome and prevention of bronchopulmonary dysplasia. (19572989)
2009
34
Inhaled nitric oxide improves lung structure and pulmonary hypertension in a model of bleomycin-induced bronchopulmonary dysplasia in neonatal rats. (19837849)
2009
35
Endostatin concentration in cord plasma predicts the development of bronchopulmonary dysplasia in very low birth weight infants. (19336373)
2009
36
The 'new' bronchopulmonary dysplasia: challenges and commentary. (19747889)
2009
37
Expression of nitric oxide synthases and endogenous NO metabolism in bronchopulmonary dysplasia. (18500734)
2008
38
Cord blood KL-6, a specific lung injury marker, correlates with the subsequent development and severity of atypical bronchopulmonary dysplasia. (18025794)
2008
39
Below median birth weight in appropriate-for-gestational-age preterm infants as a risk factor for bronchopulmonary dysplasia. (18598128)
2008
40
Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia. (19085566)
2008
41
Postnatal steroids for bronchopulmonary dysplasia: where are we now? (17382102)
2007
42
Reduction of bronchopulmonary dysplasia after participation in the Breathsavers Group of the Vermont Oxford Network Neonatal Intensive Care Quality Improvement Collaborative. (17079626)
2006
43
The genetics of bronchopulmonary dysplasia. (16860158)
2006
44
Deletion allele of angiotensin-converting enzyme is associated with increased risk and severity of bronchopulmonary dysplasia. (16356438)
2005
45
Interleukin-1 balance in the lungs of preterm infants who develop bronchopulmonary dysplasia. (15539764)
2005
46
Tenascin-C is highly expressed in respiratory distress syndrome and bronchopulmonary dysplasia. (11850444)
2002
47
Monocyte chemoattractant protein-1 and interleukin-8 are increased in bronchopulmonary dysplasia: relation to isolation of Ureaplasma urealyticum. (11478413)
2001
48
Vitamin A status and postnatal dexamethasone treatment in bronchopulmonary dysplasia. (10969101)
2000
49
Myocardial, erythropoietic, and metabolic adaptations to anemia of prematurity in infants with bronchopulmonary dysplasia. (9580761)
1998
50
Secretory leukocyte protease inhibitor and lung inflammation in developing bronchopulmonary dysplasia. (7913723)
1994

Genetic Variations for Bronchopulmonary Dysplasia

Expression for genes affiliated with Bronchopulmonary Dysplasia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bronchopulmonary Dysplasia

Search GEO for disease gene expression data for Bronchopulmonary Dysplasia.

Pathways for genes affiliated with Bronchopulmonary Dysplasia

Sources:
52QIAGEN, 54Reactome, 50PharmGKB, 30KEGG
See all sources

Pathways related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5TIMP1, FGF10
2
Hide members
10.5FGF7, FGF10
310.5TXN, SOD1
410.5ELANE, IL8, FLT1, ITGAM
5
Hide members
10.5PLA2G7, FGF7, FLT1, FGF10
6
Hide members
10.4FLT1, FGF10, PLA2G7, FGF7, TIMP1
7
Hide members
10.4FLT1, FGF10, FGF7, TIMP1, ITGAM
8
Hide members
10.4FGF7, FGF10, ITGAM, TIMP1, PLA2G7, FLT1
9
Hide members
10.4TIMP1, FLT1, CCL3, FGF10, FGF7, PLA2G7
10
Hide members
10.4FLT1, FGF10, FGF7, ITGAM, CCL3, TIMP1
11
Hide members
10.4ITGAM, FGF10, FGF7, FLT1, TIMP1, IL8
12
Hide members
10.4RBP4, ITGAM, FLT1, GRP, FGF7, IL8

Compounds for genes affiliated with Bronchopulmonary Dysplasia

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.9RNASE3, SELL, PTHLH, PLA2G7, SCGB1A1, ITGAM
2pge24510.9PLA2G7, GRP
3estrogen4510.9RNASE3
4dexamethasone45 50 29 1113.9TIMP1, SELL, RNASE3, GRP, ITGAM, RBP4
5cycloheximide4510.9FGF7, ITGAM, SFTPB, SELL, PLA2G7
6oxygen45 2411.9TXN, CCL3, SFTPB, IL8, FGF7, FLT1
7p0024510.9RBP4, PLA2G7, SCGB1A1, ITGAM, IL1RN, FLT1
8leukotriene b445 60 2412.9ITGAM, CCL3, ELANE, SELL, IL1RN, IL8
9heparin45 29 11 2413.9IL8, IL1RN, RNASE3, FGF7, FGF10, FLT1
10h2o24510.9FGF7, FLT1, SELL, ITGAM, CCL3, IL1RN
11latex4510.9CCL3, TIMP1, SCGB1A1, RBP4, ITGAM, FGF7
12nitric oxide45 11 2412.9PTHLH, CCL3, IL8, PLA2G7, ITGAM, IL1RN
13creatinine4510.9PTHLH, GRP, FLT1, RNASE3, IL1RN, ITGAM
14vegf4510.9CCL3, TIMP1, TXN, SFTPB, SELL, PTHLH
15lactate4510.9RNASE3, RBP4, TXN, TIMP1, CCL3, SOD1
16retinoic acid45 2411.9RNASE3, FGF7, FGF10, GRP, ITGAM, RBP4
17vitamin a45 11 2412.9ELANE, SFTPB, TXN, TIMP1, RBP4
18serine4510.8TXN, IL1RN, CCL3, IL8, FLT1, ITGAM
19hydrocortisone45 2 60 1113.8PTHLH, IL8, FLT1, ELANE, GRP
20rantes4510.8SELL, FGF7, ITGAM, CCL3, RNASE3
21aspirin45 50 29 2413.8IL1RN, GRP, RNASE3, ITGAM, TIMP1, PLA2G7
22indomethacin45 60 29 1113.8GRP
23histamine45 29 2412.8TIMP1, FGF7, RNASE3, IL1RN, IL8, SELL
24adenylate4510.8TIMP1, RBP4, ITGAM, GRP, FGF7, RNASE3
25superoxide45 2411.8SELL, ITGAM, TXN, ELANE
26simvastatin45 50 60 29 11 2415.8IL1RN, IL8, PTHLH, SELL, CCL3, ITGAM
27ribonucleic acid4510.8IL1RN, PTHLH, FGF7, FLT1, RBP4, SFTPB
28hyaluronic acid45 2411.8ELANE, FGF7, IL8, IL1RN, RNASE3, TIMP1
29cyclosporin a45 29 6012.8TIMP1, TXN, ITGAM, FGF7, RNASE3, IL1RN
30zymosan4510.8CCL3, IL1RN, ELANE, ITGAM, RNASE3
31fmlp4510.8SELL, IL8, CCL3, ITGAM, IL1RN, ELANE
32cysteine4510.8SOD1, TXN, RBP4, TIMP1, CCL3, SFTPB
33bleomycin45 1111.8PTHLH, TXN, TIMP1, CCL3, SFTPB, FGF7
34anaphylatoxin4510.7RNASE3, CCL3, ELANE, IL8, TXN
35alanine4510.7TXN, TIMP1, SELL, CCL3, PTHLH, SCGB1A1
36progesterone45 60 29 11 2414.7FGF7, FLT1, SCGB1A1, PTHLH, IL1RN, PLA2G7
37alpha tocopherol4510.7ITGAM, RBP4, TXN, ELANE
38actinomycin d4510.7SFTPB, GRP, FGF7, IL8, CCL3, TXN
39phorbol4510.7SELL, RNASE3, ITGAM, RBP4, TIMP1, GRP
40matrigel4510.7FLT1, GRP, FGF7, PTHLH
41testosterone45 60 11 2413.7TXN, ELANE, PTHLH, CCL3, FGF10, FGF7
42prednisolone45 29 1112.6SELL, ITGAM, PTHLH, RNASE3
43epinephrine45 11 2412.6IL1RN, ELANE, SELL, RNASE3, ITGAM, CCL3
4412-o-tetradecanoylphorbol 13-acetate4510.6GRP, TIMP1, SFTPB, ITGAM, FGF7, PTHLH
45sb 20358045 6011.6CCL3, SELL, IL1RN, FLT1, ITGAM, TIMP1
46tgf beta14510.5FLT1, FGF7, CCL3, TIMP1, IL1RN, PTHLH
47n-formylmethionyl-leucylphenylalanine4510.5ELANE, ITGAM, RNASE3, IL8, SELL
48doxycycline45 1111.5FGF7, TIMP1, SCGB1A1, ELANE, SFTPB
49vitamin d4510.3FGF7, ITGAM, ELANE, PTHLH, TXN, TIMP1
50pentoxifylline45 1111.2ITGAM, ELANE, IL8, SELL, IL1RN

GO Terms for genes affiliated with Bronchopulmonary Dysplasia

Sources:
16Gene Ontology
See all sources

Cellular components related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4SFTPB, SOD1, SCGB1A1, RBP4, FLT1, GRP
2extracellular regionGO:00557610.1ELANE, TXN, TIMP1, CCL3, SOD1, RBP4

Biological processes related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive chemotaxisGO:05091810.6FGF7, FGF10, CCL3
2secretion by lung epithelial cell involved in lung growthGO:06103310.6FGF7, FGF10
3female genitalia morphogenesisGO:04880710.6FGF10, RBP4
4neutrophil chemotaxisGO:03059310.5CCL3, ITGAM, IL8
5female pregnancyGO:00756510.5PTHLH, IL1RN, SCGB1A1
6regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.5FGF10, FGF7
7positive regulation of keratinocyte migrationGO:05154910.4FGF10, FGF7
8positive regulation of keratinocyte proliferationGO:01083810.2FGF10, FGF7

Molecular functions related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:04205610.5FGF7, FGF10, CCL3
2heparin bindingGO:00820110.2ELANE, SELL, FGF7, FGF10, ITGAM

Products for genes affiliated with Bronchopulmonary Dysplasia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bronchopulmonary Dysplasia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet