MCID: BRN056
MIFTS: 57

Bronchopulmonary Dysplasia malady

Rare diseases, Respiratory diseases, Fetal diseases categories

Summaries for Bronchopulmonary Dysplasia

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Wikipedia:65 Bronchopulmonary dysplasia (BPD; formerly chronic lung disease of infancy) is a chronic lung disorder of... more...

MalaCards based summary: Bronchopulmonary Dysplasia, also known as bpd, is related to chorioamnionitis and respiratory failure. An important gene associated with Bronchopulmonary Dysplasia is SFTPB (surfactant protein B), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Selected targets of C EBPalpha. The compounds ozone and curosurf have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and brain, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Classifications for Bronchopulmonary Dysplasia

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Sources:
32LifeMap Discovery®, 43NIH Rare Diseases, 45Novoseek, 49Orphanet, 62UMLS, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Bronchopulmonary Dysplasia, Aliases & Descriptions:

Name: Bronchopulmonary Dysplasia 32 43 45 49 62
 
Bpd 43 49


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

49
bronchopulmonary dysplasia:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Infancy,Neonatal; Age of death: normal life expectancy


External Ids:

Orphanet49 70589
MESH via Orphanet36 D001997
ICD10 via Orphanet28 P27.1
UMLS via Orphanet63 C0006287

Related Diseases for Bronchopulmonary Dysplasia

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Diseases related to Bronchopulmonary Dysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.9ELANE, IL1RN, IL8
2respiratory failure30.5SFTPB, SCGB1A1, ITGAM
3bronchiolitis30.4IL8, RNASE3
4asthma30.4SCGB1A1, PLA2G7
5vascular disease30.3ELANE, ITGAM, PLA2G7
6atopy30.2RNASE3, SCGB1A1
7bronchiectasis30.1IL8, ELANE, RNASE3
8cystic fibrosis30.0SFTPB, SCGB1A1, RNASE3, ELANE, ITGAM, IL8
9pneumonia29.9SFTPB, SCGB1A1, SELL, ELANE, ITGAM, IL8
10pulmonary hypertension10.7
11endotheliitis10.6
12borderline personality disorder10.5
13personality disorder10.4
14patent ductus arteriosus10.4
15leukemoid reaction10.3
16wilson-mikity syndrome10.3
17pulmonary function10.2
18cerebritis10.2
19funisitis10.2
20cholestasis10.2
21pneumothorax10.2
22hypoxia10.2
23blindness10.2
24malaria10.1RBP4
25gastroesophageal reflux10.1
26insulin-like growth factor i10.1
27cataract10.1
28cerebral palsy10.1
29rickets10.1
30interstitial emphysema10.1
31pulmonary edema10.1
32anemia of prematurity10.1
33neonatal respiratory failure10.1
34hemosiderosis10.1
35bronchopneumonia10.1
36periventricular leukomalacia10.1
37bronchial disease10.1
38congenital heart disease10.1
39esophagitis10.1
40obstructive lung disease10.1
41sleep disorder10.1
42hypoadrenalism10.1
43leukomalacia10.1
44pulmonary vein stenosis10.1
45meconium aspiration syndrome10.1SFTPB
46conjunctivitis10.1RNASE3
47sinusitis10.1RNASE3
48capillary leak syndrome10.0ELANE
49pustulosis palmaris et plantaris10.0ELANE
50hyper-ige recurrent infection syndrome10.0RNASE3, SELL

Graphical network of the top 20 diseases related to Bronchopulmonary Dysplasia:



Diseases related to bronchopulmonary dysplasia

Symptoms for Bronchopulmonary Dysplasia

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Drugs & Therapeutics for Bronchopulmonary Dysplasia

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Drug clinical trials:

Search ClinicalTrials for Bronchopulmonary Dysplasia

Search NIH Clinical Center for Bronchopulmonary Dysplasia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bronchopulmonary Dysplasia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchopulmonary Dysplasia:
PNEUMOSTEM

Genetic Tests for Bronchopulmonary Dysplasia

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Anatomical Context for Bronchopulmonary Dysplasia

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MalaCards organs/tissues related to Bronchopulmonary Dysplasia:

33
Lung, Endothelial, Brain, Neutrophil, Bone, Testes, Monocytes, Heart, Colon, Kidney, Bone marrow, Placenta, T cells, Fetal lung

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bronchopulmonary Dysplasia:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Bronchopulmonary Dysplasia or affiliated genes

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MGI Mouse Phenotypes related to Bronchopulmonary Dysplasia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2SFTPB, SCGB1A1, PTHLH, SELL, FGF10
2MP:00053798.0SCGB1A1, PTHLH, SELL, RBP4, FGF10
3MP:00053847.7FGF10, RBP4, IL1RN, ITGAM, SELL, PTHLH
4MP:00053976.9PTHLH, SELL, ELANE, ITGAM, IL1RN, IL8
5MP:00053766.6FGF10, SFTPB, SCGB1A1, PTHLH, SELL, ELANE
6MP:00053876.6SCGB1A1, PTHLH, SELL, ELANE, ITGAM, IL1RN

Publications for Bronchopulmonary Dysplasia

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Articles related to Bronchopulmonary Dysplasia:

(show top 50)    (show all 612)
idTitleAuthorsYear
1
Association between Hemodynamically Significant Patent Ductus Arteriosus and Bronchopulmonary Dysplasia. (25882876)
2015
2
Sildenafil for the Treatment of Pulmonary Arterial Hypertension in Infants with Bronchopulmonary Dysplasia. (25824807)
2015
3
Ventilatory and sensory responses in adult survivors of preterm birth and bronchopulmonary dysplasia with reduced exercise capacity. (25380058)
2014
4
Histologic evidence of intrapulmonary anastomoses by three-dimensional reconstruction in severe bronchopulmonary dysplasia. (23987309)
2013
5
Healthcare utilization and health-related quality of life of adult survivors of preterm birth complicated by bronchopulmonary dysplasia. (23445350)
2013
6
Increased volume of tracheal aspirate fluid predicts the development of bronchopulmonary dysplasia. (22980969)
2013
7
Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins. (23933064)
2013
8
Gene expression profiling in preterm infants: new aspects of bronchopulmonary dysplasia development. (24194948)
2013
9
Ventilatory control in infants, children, and adults with bronchopulmonary dysplasia. (23886637)
2013
10
Azithromycin to prevent bronchopulmonary dysplasia in ureaplasma-infected preterm infants: pharmacokinetics, safety, microbial response, and clinical outcomes with a 20-milligram-per-kilogram single intravenous dose. (23439637)
2013
11
Chorioamnionitis and Bronchopulmonary Dysplasia in Evolution. (24210583)
2013
12
Human umbilical cord blood mononuclear cells in a double-hit model of bronchopulmonary dysplasia in neonatal mice. (24069341)
2013
13
Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia. (22497282)
2012
14
Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia. (22287607)
2012
15
Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension. (22837858)
2012
16
Tension pneumothorax at anaesthetic induction in an ex-premature infant with bronchopulmonary dysplasia. (22967679)
2012
17
Sildenafil therapy for bronchopulmonary dysplasia: not quite yet. (22202953)
2012
18
Nutritional strategies and growth in extremely low birth weight infants with bronchopulmonary dysplasia over the past 10 years. (21617642)
2012
19
A Relationship between Epithelial Maturation, Bronchopulmonary Dysplasia, and Chronic Obstructive Pulmonary Disease. (23320163)
2012
20
High incidence of rickets in extremely low birth weight infants with severe parenteral nutrition-associated cholestasis and bronchopulmonary dysplasia. (23255857)
2012
21
Current pharmacologic approaches for prevention and treatment of bronchopulmonary dysplasia. (22262977)
2012
22
Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. (22328358)
2012
23
Inflammatory cytokines in gastric fluid at birth and the development of bronchopulmonary dysplasia. (21438921)
2011
24
Clarithromycin in preventing bronchopulmonary dysplasia in Ureaplasma urealyticum-positive preterm infants. (22123897)
2011
25
A role for matrix metalloproteinase 9 in IFNI^-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia. (21216975)
2011
26
Nebulized furosemide in the treatment of bronchopulmonary dysplasia in preterm infants. (22477820)
2011
27
The new bronchopulmonary dysplasia. (21169836)
2011
28
Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study); a multicenter randomized placebo controlled trial. (22070744)
2011
29
Genetic and epidemiological risk factors in the development of bronchopulmonary dysplasia. (20826912)
2010
30
Inhaled nitric oxide does not prevent bronchopulmonary dysplasia. (20876257)
2010
31
Neonatal bronchopulmonary dysplasia predicts abnormal pulmonary HRCT scans in long-term survivors of extreme preterm birth. (19158126)
2009
32
Ventilatory management and bronchopulmonary dysplasia in preterm infants. (19766071)
2009
33
Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants. (19204058)
2009
34
Prologue: advances in bronchopulmonary dysplasia. (19782014)
2009
35
Prevention and treatment of bronchopulmonary dysplasia: contemporary status and future outlook. (18228098)
2008
36
Non-invasive positive pressure ventilation in the preterm neonate: reducing endotrauma and the incidence of bronchopulmonary dysplasia. (17768159)
2008
37
Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia. (18330726)
2008
38
Epithelial lining fluid neutrophil-gelatinase-associated lipocalin levels in premature newborns with bronchopulmonary dysplasia and patency of ductus arteriosus. (18336743)
2008
39
Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate. (18676410)
2008
40
Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema. (17394419)
2007
41
FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. (17071719)
2007
42
Ventilatory pump failure and strategies to prevent bronchopulmonary dysplasia. (17606588)
2007
43
Genetic analysis of the dystroglycan gene in bronchopulmonary dysplasia affected premature newborns. (17196572)
2007
44
Does bronchopulmonary dysplasia change the postoperative outcome of herniorrhaphy in premature babies? (17474949)
2007
45
Reduction of bronchopulmonary dysplasia after participation in the Breathsavers Group of the Vermont Oxford Network Neonatal Intensive Care Quality Improvement Collaborative. (17079626)
2006
46
Bronchopulmonary dysplasia in very low birth weight infants is associated with prolonged hospital stay. (17006525)
2006
47
Monocyte chemoattractant protein-1 and interleukin-8 are increased in bronchopulmonary dysplasia: relation to isolation of Ureaplasma urealyticum. (11478413)
2001
48
Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. (9369827)
1997
49
Elevation of interleukin-8 and interleukin-6 precedes the influx of neutrophils in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. (9407566)
1997
50
Immunohistochemical study of copper-zinc and manganese superoxide dismutases in the lungs of human fetuses and newborn infants: developmental profile and alterations in hyaline membrane disease and bronchopulmonary dysplasia. (8236811)
1993

Variations for Bronchopulmonary Dysplasia

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Expression for genes affiliated with Bronchopulmonary Dysplasia

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Search GEO for disease gene expression data for Bronchopulmonary Dysplasia.

Pathways for genes affiliated with Bronchopulmonary Dysplasia

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Pathways related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SELL, ELANE
29.6ELANE, SCGB1A1
39.3ITGAM, ELANE
49.3IL8, ITGAM
58.8IL8, ITGAM, ELANE

Compounds for genes affiliated with Bronchopulmonary Dysplasia

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Compounds related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1ozone459.7SCGB1A1, RNASE3, SFTPB
2curosurf459.5SFTPB, IL8, ELANE
3survanta459.5IL8, ELANE, SFTPB
4filgrastim45 1310.2ITGAM, ELANE, IL1RN
5phorbol459.1ITGAM, RNASE3, RBP4, SELL
6zymosan459.1ELANE, ITGAM, IL1RN, RNASE3
7cuprophan459.1IL1RN, ITGAM, ELANE, SELL
8polysulfone459.0IL1RN, ITGAM, ELANE, SELL
9montelukast45 51 30 1312.0RNASE3, IL8, ITGAM
10vitamin a45 26 1311.0RBP4, IL1RN, ELANE, SCGB1A1, SFTPB
11latex458.9ITGAM, RBP4, IL1RN, RNASE3, SCGB1A1
12aebsf458.9ELANE, PLA2G7, IL8
13atorvastatin45 51 30 26 1312.8SELL, ITGAM, IL1RN, PLA2G7
14rolipram45 61 3010.8ITGAM, SELL, ELANE, IL8
15hyaluronic acid45 269.8RNASE3, IL1RN, ELANE, SCGB1A1, IL8
16rantes458.7RNASE3, ITGAM, IL1RN, IL8, SELL
17epinephrine45 26 1310.7ITGAM, SELL, RNASE3, ELANE, IL1RN
18n-formylmethionyl-leucylphenylalanine458.6SELL, RNASE3, ELANE, ITGAM, IL8
19histamine45 30 2610.6RNASE3, SELL, IL1RN, ITGAM, IL8
20pentoxifylline45 139.6SELL, ELANE, ITGAM, IL1RN, IL8
21aprotinin45 139.5ELANE, IL8, PTHLH, SELL
22p002458.5ITGAM, RBP4, PLA2G7, IL1RN, RNASE3, SCGB1A1
23phospholipid458.5RBP4, PLA2G7, SCGB1A1, SFTPB, PTHLH
24prednisolone45 30 1310.4ITGAM, IL1RN, PTHLH, RNASE3, SELL
25fibrinogen458.3PLA2G7, IL1RN, ITGAM, ELANE, RNASE3, SFTPB
26aspirin45 51 30 2611.3IL1RN, PLA2G7, ITGAM, ELANE, RNASE3, SELL
27fmlp458.3IL8, SELL, RNASE3, ELANE, ITGAM, IL1RN
28hydrocortisone45 3 61 1311.3ELANE, IL1RN, PTHLH, IL8
29progesterone45 30 61 26 1312.2PLA2G7, SCGB1A1, IL1RN, PTHLH, SFTPB, RBP4
30h2o2458.1ELANE, IL8, IL1RN, RNASE3, SELL, ITGAM
31superoxide45 269.0SELL, IL8, PLA2G7, ITGAM, IL1RN, ELANE
32simvastatin45 51 61 30 26 1313.0PTHLH, RBP4, IL1RN, ITGAM, SELL, IL8
33adenylate457.9RBP4, ITGAM, ELANE, RNASE3, PTHLH, IL1RN
34cyclosporin a45 30 619.9ITGAM, RNASE3, IL1RN, ELANE, IL8
35leukotriene b445 61 269.8RNASE3, ELANE, ITGAM, IL1RN, IL8, SELL
36creatinine457.8IL1RN, ITGAM, RNASE3, SELL, PTHLH, SCGB1A1
37estrogen457.7SCGB1A1, RBP4, PLA2G7, ELANE, RNASE3, PTHLH
38cycloheximide457.5IL8, PLA2G7, IL1RN, ITGAM, SFTPB, PTHLH
39lipid457.4IL1RN, PLA2G7, PTHLH, SCGB1A1, SFTPB, ITGAM
40vegf457.3RNASE3, SELL, PTHLH, SFTPB, IL8, FGF10
41nitric oxide45 26 139.2PTHLH, SFTPB, SCGB1A1, RNASE3, ITGAM, PLA2G7
42lactate457.2IL8, SELL, PTHLH, RBP4, RNASE3, ELANE
43calcium45 51 26 1310.1SFTPB, RBP4, IL1RN, PTHLH, RNASE3, ITGAM
44heparin45 30 26 1310.0FGF10, IL8, IL1RN, ELANE, RNASE3, SELL
45retinoic acid45 268.0IL1RN, FGF10, ELANE, RBP4, ITGAM, SFTPB
46dexamethasone45 51 30 1310.0ITGAM, PLA2G7, IL8, IL1RN, RNASE3, SELL
47pge2456.7ITGAM, PLA2G7, IL8, IL1RN, ELANE, RNASE3
48serine456.7ELANE, PTHLH, SFTPB, IL8, RBP4, ITGAM
49endotoxin456.6PLA2G7, SCGB1A1, SELL, RNASE3, ELANE, ITGAM
50oxygen45 267.4IL8, PTHLH, SCGB1A1, SELL, ELANE, ITGAM

GO Terms for genes affiliated with Bronchopulmonary Dysplasia

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Cellular components related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.2RNASE3, ELANE, IL8, PLA2G7, RBP4, FGF10
2extracellular spaceGO:00056157.2FGF10, SFTPB, SCGB1A1, PTHLH, IL1RN, IL8

Biological processes related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female genitalia morphogenesisGO:00488079.9FGF10, RBP4
2neutrophil chemotaxisGO:00305939.3IL8, ITGAM
3induction of positive chemotaxisGO:00509309.2FGF10, IL8
4response to lipopolysaccharideGO:00324968.9FGF10, IL1RN, ELANE, SCGB1A1
5female pregnancyGO:00075658.9SCGB1A1, PTHLH, IL1RN
6leukocyte migrationGO:00509008.9ITGAM, ELANE, SELL

Molecular functions related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082018.6FGF10, ITGAM, ELANE, SELL

Products for genes affiliated with Bronchopulmonary Dysplasia

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Sources for Bronchopulmonary Dysplasia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet