BPD
MCID: BRN056
MIFTS: 47

Bronchopulmonary Dysplasia (BPD) malady

Respiratory diseases, Fetal diseases categories

Summaries for Bronchopulmonary Dysplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Bronchopulmonary dysplasia (BPD; formerly chronic lung disease of infancy) is a chronic lung disorder... more...

MalaCards: Bronchopulmonary Dysplasia, also known as BPD, is related to chorioamnionitis and respiratory failure. An important gene associated with Bronchopulmonary Dysplasia is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are NF-KappaB Family Pathway and FGFR1b ligand binding and activation. The compounds endotoxin and pge2 have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Bronchopulmonary Dysplasia

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42NIH Rare Diseases, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
bronchopulmonary dysplasia:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy; Age of death: Normal


Aliases & Descriptions:

bronchopulmonary dysplasia 42 44 48 30 60
bpd 42 48


External Ids:

MESH via Orphanet35 D001997
ICD10 via Orphanet26 P27.1
SNOMED-CT via Orphanet57 67569000
UMLS via Orphanet61 C0006287

Related Diseases for Bronchopulmonary Dysplasia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bronchopulmonary Dysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 196)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.7ELANE, IL1RN, FLT1, IL8
2respiratory failure30.4RNASE3, SCGB1A1, SFTPB, ELANE
3retinopathy of prematurity30.3FLT1
4bronchiolitis30.2CCL3, IL8, RNASE3
5vascular disease30.2ITGAM, SOD1, ELANE, PLA2G7, GRP
6asthma30.2SCGB1A1, PLA2G7
7cystic fibrosis30.0SCGB1A1, RBP4, ITGAM, FGF7, RNASE3, IL8
8pneumonia30.0GRP, ITGAM, RBP4, SCGB1A1, SFTPB, CCL3
9pulmonary emphysema30.0ELANE
10bronchiectasis30.0RNASE3, IL8, ELANE
11hypertension10.7
12borderline personality disorder10.4
13personality disorder10.3
14patent ductus arteriosus10.3
15leukemoid reaction10.2
16sandhoff disease10.2
17cerebritis10.2
18funisitis10.2
19cholestasis10.2
20pneumothorax10.2
21periventricular leukomalacia10.0
22interstitial emphysema10.0
23pulmonary edema10.0
24anemia of prematurity10.0
25neonatal respiratory failure10.0
26toxic pneumonitis10.0
27rickets10.0
28gastroesophageal reflux disease10.0
29bronchopneumonia10.0
30bronchial disease10.0
31cataract10.0
32cerebral palsy10.0
33esophagitis10.0
34obstructive lung disease10.0
35pulmonary embolism10.0
36sleep disorder10.0
37tracheal disease10.0
38infant acute respiratory distress syndrome10.0
39nephritis10.0IL1RN, RBP4, SCGB1A1
40atopy10.0RNASE3, SCGB1A1
41glomerulonephritis10.0RBP4, IL1RN, ELANE, SCGB1A1, PLA2G7
42vasculitis10.0ITGAM, SELL, ELANE
43rhinitis10.0RNASE3, IL8, SCGB1A1
44coronary heart disease10.0ITGAM, PLA2G7
45gastric ulcer10.0FGF7
46acute myocardial infarction10.0TXN, ITGAM
47diabetes mellitus10.0ITGAM, TXN, SELL, PLA2G7, RBP4, SOD1
48malaria10.0RBP4
49hypercholesterolemia10.0RBP4, ITGAM, PLA2G7
50sinusitis10.0RNASE3

Graphical network of the top 20 diseases related to Bronchopulmonary Dysplasia:



Diseases related to bronchopulmonary dysplasia

Clinical Features for Bronchopulmonary Dysplasia

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Drugs & Therapeutics for Bronchopulmonary Dysplasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bronchopulmonary Dysplasia

Drug clinical trials:

Search ClinicalTrials for Bronchopulmonary Dysplasia

Search NIH Clinical Center for Bronchopulmonary Dysplasia

Search CenterWatch for Bronchopulmonary Dysplasia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bronchopulmonary Dysplasia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchopulmonary Dysplasia:
PNEUMOSTEM

Genetic Tests for Bronchopulmonary Dysplasia

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Anatomical Context for Bronchopulmonary Dysplasia

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Bronchopulmonary Dysplasia:

32
Lung

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bronchopulmonary Dysplasia:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Bronchopulmonary Dysplasia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bronchopulmonary Dysplasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.6CCL3, SOD1, SCGB1A1, RBP4, ITGAM, FGF10
2MP:000538710.6ELANE, TIMP1, CCL3, SOD1, SCGB1A1, ITGAM
3MP:000539710.5FLT1, ITGAM, SOD1, CCL3, TIMP1, FGF10
4MP:000538410.5TXN, CCL3, SOD1, RBP4, ITGAM, FLT1
5MP:000537910.5SELL, RBP4, SCGB1A1
6MP:000538910.5RBP4, FLT1, FGF10, FGF7, IL1RN
7MP:001076810.3TXN, TIMP1, CCL3, SFTPB, SOD1, SCGB1A1
8MP:000538510.1TIMP1, SOD1, RBP4, FLT1, FGF10, IL1RN

Publications for Bronchopulmonary Dysplasia

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Genetic Variations for Bronchopulmonary Dysplasia

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Expression for genes affiliated with Bronchopulmonary Dysplasia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bronchopulmonary Dysplasia

Search GEO for disease gene expression data for Bronchopulmonary Dysplasia.

Pathways for genes affiliated with Bronchopulmonary Dysplasia

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Sources:
51QIAGEN, 53Reactome, 49PharmGKB, 29KEGG
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Pathways related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5FGF10, TIMP1
2
Hide members
10.5FGF10, FGF7
310.5TXN, SOD1
410.5ELANE, IL8, FLT1, ITGAM
5
Hide members
10.5FLT1, FGF10, FGF7, PLA2G7
6
Hide members
10.4PLA2G7, FGF7, FGF10, FLT1, TIMP1
7
Hide members
10.4TIMP1, ITGAM, FLT1, FGF10, FGF7, PLA2G7
8
Hide members
10.4FGF7, FGF10, FLT1, ITGAM, TIMP1
9
Hide members
10.4TIMP1, CCL3, FLT1, FGF10, FGF7, PLA2G7
10
Hide members
10.4TIMP1, CCL3, ITGAM, FLT1, FGF10, FGF7
11
Hide members
10.4FGF10, FLT1, ITGAM, CCL3, TIMP1, FGF7
12
Hide members
10.4CCL3, RBP4, ITGAM, FLT1, GRP, FGF10

Compounds for genes affiliated with Bronchopulmonary Dysplasia

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.9RNASE3, SELL, PTHLH, PLA2G7, SCGB1A1, ITGAM
2pge24410.9PLA2G7, GRP
3estrogen4410.9RNASE3
4dexamethasone44 49 28 1113.9TIMP1, SELL, RNASE3, GRP, ITGAM, RBP4
5cycloheximide4410.9FGF7, ITGAM, SFTPB, SELL, PLA2G7
6oxygen44 2411.9TXN, CCL3, SFTPB, IL8, FGF7, FLT1
7p0024410.9RBP4, PLA2G7, SCGB1A1, ITGAM, IL1RN, FLT1
8leukotriene b444 59 2412.9ITGAM, CCL3, ELANE, SELL, IL1RN, IL8
9heparin44 28 11 2413.9IL8, IL1RN, RNASE3, FGF7, FGF10, FLT1
10h2o24410.9FGF7, FLT1, SELL, ITGAM, CCL3, IL1RN
11latex4410.9CCL3, TIMP1, SCGB1A1, RBP4, ITGAM, FGF7
12nitric oxide44 11 2412.9PTHLH, CCL3, IL8, PLA2G7, ITGAM, IL1RN
13creatinine4410.9PTHLH, GRP, FLT1, RNASE3, IL1RN, ITGAM
14vegf4410.9CCL3, TIMP1, TXN, SFTPB, SELL, PTHLH
15lactate4410.9RNASE3, RBP4, TXN, TIMP1, CCL3, SOD1
16retinoic acid44 2411.9RNASE3, FGF7, FGF10, GRP, ITGAM, RBP4
17vitamin a44 11 2412.9ELANE, SFTPB, TXN, TIMP1, RBP4
18serine4410.8TXN, IL1RN, CCL3, IL8, FLT1, ITGAM
19hydrocortisone44 2 59 1113.8PTHLH, IL8, FLT1, ELANE, GRP
20rantes4410.8SELL, FGF7, ITGAM, CCL3, RNASE3
21aspirin44 49 28 2413.8IL1RN, GRP, RNASE3, ITGAM, TIMP1, PLA2G7
22indomethacin44 59 28 1113.8GRP
23histamine44 28 2412.8TIMP1, FGF7, RNASE3, IL1RN, IL8, SELL
24adenylate4410.8TIMP1, RBP4, ITGAM, GRP, FGF7, RNASE3
25superoxide44 2411.8SELL, ITGAM, TXN, ELANE
26simvastatin44 49 59 28 11 2415.8IL1RN, IL8, PTHLH, SELL, CCL3, ITGAM
27ribonucleic acid4410.8IL1RN, PTHLH, FGF7, FLT1, RBP4, SFTPB
28hyaluronic acid44 2411.8ELANE, FGF7, IL8, IL1RN, RNASE3, TIMP1
29cyclosporin a44 28 5912.8TIMP1, TXN, ITGAM, FGF7, RNASE3, IL1RN
30zymosan4410.8CCL3, IL1RN, ELANE, ITGAM, RNASE3
31fmlp4410.8SELL, IL8, CCL3, ITGAM, IL1RN, ELANE
32cysteine4410.8SOD1, TXN, RBP4, TIMP1, CCL3, SFTPB
33bleomycin44 1111.8PTHLH, TXN, TIMP1, CCL3, SFTPB, FGF7
34anaphylatoxin4410.7RNASE3, CCL3, ELANE, IL8, TXN
35alanine4410.7TXN, TIMP1, SELL, CCL3, PTHLH, SCGB1A1
36progesterone44 59 28 11 2414.7FGF7, FLT1, SCGB1A1, PTHLH, IL1RN, PLA2G7
37alpha tocopherol4410.7ITGAM, RBP4, TXN, ELANE
38actinomycin d4410.7SFTPB, GRP, FGF7, IL8, CCL3, TXN
39phorbol4410.7SELL, RNASE3, ITGAM, RBP4, TIMP1, GRP
40matrigel4410.7FLT1, GRP, FGF7, PTHLH
41testosterone44 59 11 2413.7TXN, ELANE, PTHLH, CCL3, FGF10, FGF7
42prednisolone44 28 1112.6SELL, ITGAM, PTHLH, RNASE3
43epinephrine44 11 2412.6IL1RN, ELANE, SELL, RNASE3, ITGAM, CCL3
4412-o-tetradecanoylphorbol 13-acetate4410.6GRP, TIMP1, SFTPB, ITGAM, FGF7, PTHLH
45sb 20358044 5911.6CCL3, SELL, IL1RN, FLT1, ITGAM, TIMP1
46tgf beta14410.5FLT1, FGF7, CCL3, TIMP1, IL1RN, PTHLH
47n-formylmethionyl-leucylphenylalanine4410.5ELANE, ITGAM, RNASE3, IL8, SELL
48doxycycline44 1111.5FGF7, TIMP1, SCGB1A1, ELANE, SFTPB
49vitamin d4410.3FGF7, ITGAM, ELANE, PTHLH, TXN, TIMP1
50pentoxifylline44 1111.2ITGAM, ELANE, IL8, SELL, IL1RN

GO Terms for genes affiliated with Bronchopulmonary Dysplasia

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16Gene Ontology
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Cellular components related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4SFTPB, SOD1, SCGB1A1, RBP4, FLT1, GRP
2extracellular regionGO:00557610.1ELANE, TXN, TIMP1, CCL3, SOD1, RBP4

Biological processes related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive chemotaxisGO:05091810.6FGF7, FGF10, CCL3
2secretion by lung epithelial cell involved in lung growthGO:06103310.6FGF7, FGF10
3female genitalia morphogenesisGO:04880710.6FGF10, RBP4
4neutrophil chemotaxisGO:03059310.5CCL3, ITGAM, IL8
5female pregnancyGO:00756510.5PTHLH, IL1RN, SCGB1A1
6regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.5FGF10, FGF7
7positive regulation of keratinocyte migrationGO:05154910.4FGF10, FGF7
8positive regulation of keratinocyte proliferationGO:01083810.2FGF10, FGF7

Molecular functions related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:04205610.5FGF7, FGF10, CCL3
2heparin bindingGO:00820110.2ELANE, SELL, FGF7, FGF10, ITGAM

Products for genes affiliated with Bronchopulmonary Dysplasia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bronchopulmonary Dysplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet