BPD
MCID: BRN056
MIFTS: 56

Bronchopulmonary Dysplasia (BPD) malady

Rare diseases, Respiratory diseases, Fetal diseases categories
Download this MalaCard

Summaries for Bronchopulmonary Dysplasia

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Bronchopulmonary dysplasia (BPD; formerly chronic lung disease of infancy) is a chronic lung disorder... more...

MalaCards: Bronchopulmonary Dysplasia, also known as BPD, is related to chorioamnionitis and respiratory failure. An important gene associated with Bronchopulmonary Dysplasia is SFTPB (surfactant protein B), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Selected targets of C EBPalpha. The compounds ozone and curosurf have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and brain, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Classifications for Bronchopulmonary Dysplasia

About this section
Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 31LifeMap Discovery™, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

49
bronchopulmonary dysplasia:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy; Age of death: Normal


Aliases & Descriptions:

bronchopulmonary dysplasia 43 45 49 31 62
bpd 43 49


External Ids:

MESH via Orphanet36 D001997
ICD10 via Orphanet26 P27.1
SNOMED-CT via Orphanet59 67569000
UMLS via Orphanet63 C0006287

Related Diseases for Bronchopulmonary Dysplasia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Bronchopulmonary Dysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.8IL1RN, ELANE, IL8
2respiratory failure30.5SFTPB, SCGB1A1, ITGAM
3bronchiolitis30.4RNASE3, IL8
4asthma30.4PLA2G7, SCGB1A1
5atopy30.2SCGB1A1, RNASE3
6bronchiectasis30.1RNASE3, ELANE, IL8
7vascular disease30.0PLA2G7, ITGAM, ELANE
8cystic fibrosis29.9ELANE, SFTPB, IL8, SCGB1A1, RBP4, ITGAM
9pneumonia29.8SCGB1A1, SFTPB, SELL, ELANE, RBP4, PLA2G7
10hypertension10.7
11endotheliitis10.6
12borderline personality disorder10.4
13personality disorder10.4
14patent ductus arteriosus10.3
15leukemoid reaction10.3
16retinopathy of prematurity10.3
17wilson-mikity syndrome10.3
18sandhoff disease10.2
19cerebritis10.2
20funisitis10.2
21cholestasis10.2
22pneumothorax10.2
23hypoxia10.2
24pulmonary function10.2
25blindness10.2
26malaria10.1RBP4
27meconium aspiration syndrome10.1SFTPB
28conjunctivitis10.1RNASE3
29sinusitis10.1RNASE3
30capillary leak syndrome10.1ELANE
31pustulosis palmaris et plantaris10.1ELANE
32autosomal dominant hyper ige syndrome10.1RNASE3, SELL
33leukocyte adhesion deficiency10.1ITGAM
34silicosis10.1SCGB1A1, IL1RN
35congenital diaphragmatic hernia10.1FGF10, SFTPB
36synovitis10.1IL8, IL1RN
37common cold10.1RNASE3, IL8
38pulmonary eosinophilia10.1IL8, RNASE3
39arthus reaction10.1SELL, ELANE
40allergic rhinitis10.1IL8, RNASE3
41vernal keratoconjunctivitis10.1RNASE3, IL8
42gastritis10.1IL1RN, IL8
43bronchiolitis obliterans10.1IL8, SCGB1A1
44kawasaki disease10.1ELANE, SELL
45duodenal ulcer10.1IL8, IL1RN
46juvenile rheumatoid arthritis10.1PLA2G7, IL1RN
47nephritis10.1SCGB1A1, IL1RN, RBP4
48rickets10.0
49gastroesophageal reflux disease10.0
50interstitial emphysema10.0

Graphical network of the top 20 diseases related to Bronchopulmonary Dysplasia:



Diseases related to bronchopulmonary dysplasia

Symptoms for Bronchopulmonary Dysplasia

About this section

Drugs & Therapeutics for Bronchopulmonary Dysplasia

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Bronchopulmonary Dysplasia

Search NIH Clinical Center for Bronchopulmonary Dysplasia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bronchopulmonary Dysplasia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchopulmonary Dysplasia:
PNEUMOSTEM

Genetic Tests for Bronchopulmonary Dysplasia

About this section

Anatomical Context for Bronchopulmonary Dysplasia

About this section
Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Bronchopulmonary Dysplasia:

33
Lung, Endothelial, Brain, Testes, Monocytes, Bone, Colon, Placenta, Heart, Bone marrow, Fetal lung

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bronchopulmonary Dysplasia:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Bronchopulmonary Dysplasia or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Bronchopulmonary Dysplasia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2SFTPB, SCGB1A1, PTHLH, SELL, FGF10
2MP:00053798.0SCGB1A1, PTHLH, SELL, RBP4, FGF10
3MP:00053847.7FGF10, RBP4, IL1RN, ITGAM, SELL, PTHLH
4MP:00053976.9PTHLH, SELL, ELANE, ITGAM, IL1RN, IL8
5MP:00053766.6FGF10, SFTPB, SCGB1A1, PTHLH, SELL, ELANE
6MP:00053876.6SCGB1A1, PTHLH, SELL, ELANE, ITGAM, IL1RN

Publications for Bronchopulmonary Dysplasia

About this section
Sources:
52PubMed
See all sources

Articles related to Bronchopulmonary Dysplasia:

(show top 50)    (show all 564)
idTitleAuthorsYear
1
Healthcare utilization and health-related quality of life of adult survivors of preterm birth complicated by bronchopulmonary dysplasia. (23445350)
2013
2
Increased volume of tracheal aspirate fluid predicts the development of bronchopulmonary dysplasia. (22980969)
2013
3
Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins. (23933064)
2013
4
Gene expression profiling in preterm infants: new aspects of bronchopulmonary dysplasia development. (24194948)
2013
5
Ventilatory control in infants, children, and adults with bronchopulmonary dysplasia. (23886637)
2013
6
Azithromycin to prevent bronchopulmonary dysplasia in ureaplasma-infected preterm infants: pharmacokinetics, safety, microbial response, and clinical outcomes with a 20-milligram-per-kilogram single intravenous dose. (23439637)
2013
7
Chorioamnionitis and Bronchopulmonary Dysplasia in Evolution. (24210583)
2013
8
Human umbilical cord blood mononuclear cells in a double-hit model of bronchopulmonary dysplasia in neonatal mice. (24069341)
2013
9
B-type natriuretic peptide levels in preterm neonates with bronchopulmonary dysplasia: A marker of severity? (24214578)
2013
10
MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. (24301780)
2013
11
Bronchopulmonary dysplasia: a review. (23420126)
2013
12
Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia. (22497282)
2012
13
Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia. (22287607)
2012
14
Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension. (22837858)
2012
15
Tension pneumothorax at anaesthetic induction in an ex-premature infant with bronchopulmonary dysplasia. (22967679)
2012
16
Sildenafil therapy for bronchopulmonary dysplasia: not quite yet. (22202953)
2012
17
Nutritional strategies and growth in extremely low birth weight infants with bronchopulmonary dysplasia over the past 10 years. (21617642)
2012
18
A Relationship between Epithelial Maturation, Bronchopulmonary Dysplasia, and Chronic Obstructive Pulmonary Disease. (23320163)
2012
19
High incidence of rickets in extremely low birth weight infants with severe parenteral nutrition-associated cholestasis and bronchopulmonary dysplasia. (23255857)
2012
20
Current pharmacologic approaches for prevention and treatment of bronchopulmonary dysplasia. (22262977)
2012
21
Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. (22328358)
2012
22
Inflammatory cytokines in gastric fluid at birth and the development of bronchopulmonary dysplasia. (21438921)
2011
23
Clarithromycin in preventing bronchopulmonary dysplasia in Ureaplasma urealyticum-positive preterm infants. (22123897)
2011
24
A role for matrix metalloproteinase 9 in IFNI^-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia. (21216975)
2011
25
Nebulized furosemide in the treatment of bronchopulmonary dysplasia in preterm infants. (22477820)
2011
26
The new bronchopulmonary dysplasia. (21169836)
2011
27
Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study); a multicenter randomized placebo controlled trial. (22070744)
2011
28
Genetic and epidemiological risk factors in the development of bronchopulmonary dysplasia. (20826912)
2010
29
Inhaled nitric oxide does not prevent bronchopulmonary dysplasia. (20876257)
2010
30
Policy statement--postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia. (20819899)
2010
31
Neonatal bronchopulmonary dysplasia predicts abnormal pulmonary HRCT scans in long-term survivors of extreme preterm birth. (19158126)
2009
32
Ventilatory management and bronchopulmonary dysplasia in preterm infants. (19766071)
2009
33
Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants. (19204058)
2009
34
Prologue: advances in bronchopulmonary dysplasia. (19782014)
2009
35
Prevention and treatment of bronchopulmonary dysplasia: contemporary status and future outlook. (18228098)
2008
36
Non-invasive positive pressure ventilation in the preterm neonate: reducing endotrauma and the incidence of bronchopulmonary dysplasia. (17768159)
2008
37
Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia. (18330726)
2008
38
Epithelial lining fluid neutrophil-gelatinase-associated lipocalin levels in premature newborns with bronchopulmonary dysplasia and patency of ductus arteriosus. (18336743)
2008
39
Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate. (18676410)
2008
40
Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema. (17394419)
2007
41
FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. (17071719)
2007
42
Ventilatory pump failure and strategies to prevent bronchopulmonary dysplasia. (17606588)
2007
43
Genetic analysis of the dystroglycan gene in bronchopulmonary dysplasia affected premature newborns. (17196572)
2007
44
Does bronchopulmonary dysplasia change the postoperative outcome of herniorrhaphy in premature babies? (17474949)
2007
45
Reduction of bronchopulmonary dysplasia after participation in the Breathsavers Group of the Vermont Oxford Network Neonatal Intensive Care Quality Improvement Collaborative. (17079626)
2006
46
Bronchopulmonary dysplasia in very low birth weight infants is associated with prolonged hospital stay. (17006525)
2006
47
Monocyte chemoattractant protein-1 and interleukin-8 are increased in bronchopulmonary dysplasia: relation to isolation of Ureaplasma urealyticum. (11478413)
2001
48
Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. (9369827)
1997
49
Elevation of interleukin-8 and interleukin-6 precedes the influx of neutrophils in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. (9407566)
1997
50
Immunohistochemical study of copper-zinc and manganese superoxide dismutases in the lungs of human fetuses and newborn infants: developmental profile and alterations in hyaline membrane disease and bronchopulmonary dysplasia. (8236811)
1993

Variations for Bronchopulmonary Dysplasia

About this section

Expression for genes affiliated with Bronchopulmonary Dysplasia

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bronchopulmonary Dysplasia

Search GEO for disease gene expression data for Bronchopulmonary Dysplasia.

Pathways for genes affiliated with Bronchopulmonary Dysplasia

About this section
Sources:
50PathCards, 60Thomson Reuters, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SELL, ELANE
29.6SCGB1A1, ELANE
39.3ELANE, ITGAM
49.3IL8, ITGAM
58.8IL8, ITGAM, ELANE

Compounds for genes affiliated with Bronchopulmonary Dysplasia

About this section
Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1ozone459.7SCGB1A1, RNASE3, SFTPB
2curosurf459.5SFTPB, IL8, ELANE
3survanta459.5IL8, ELANE, SFTPB
4filgrastim45 1110.2ITGAM, ELANE, IL1RN
5phorbol459.1ITGAM, RNASE3, RBP4, SELL
6zymosan459.1ELANE, ITGAM, IL1RN, RNASE3
7cuprophan459.1IL1RN, ITGAM, ELANE, SELL
8polysulfone459.0IL1RN, ITGAM, ELANE, SELL
9montelukast45 51 29 1112.0RNASE3, IL8, ITGAM
10vitamin a45 24 1111.0RBP4, IL1RN, ELANE, SCGB1A1, SFTPB
11latex458.9ITGAM, RBP4, IL1RN, RNASE3, SCGB1A1
12aebsf458.9ELANE, PLA2G7, IL8
13atorvastatin45 51 29 24 1112.8SELL, ITGAM, IL1RN, PLA2G7
14rolipram45 61 2910.8ITGAM, SELL, ELANE, IL8
15hyaluronic acid45 249.8RNASE3, IL1RN, ELANE, SCGB1A1, IL8
16rantes458.7RNASE3, ITGAM, IL1RN, IL8, SELL
17epinephrine45 24 1110.7ITGAM, SELL, RNASE3, ELANE, IL1RN
18n-formylmethionyl-leucylphenylalanine458.6SELL, RNASE3, ELANE, ITGAM, IL8
19histamine45 29 2410.6RNASE3, SELL, IL1RN, ITGAM, IL8
20pentoxifylline45 119.6SELL, ELANE, ITGAM, IL1RN, IL8
21aprotinin45 119.5ELANE, IL8, PTHLH, SELL
22p002458.5ITGAM, RBP4, PLA2G7, IL1RN, RNASE3, SCGB1A1
23phospholipid458.5RBP4, PLA2G7, SCGB1A1, SFTPB, PTHLH
24prednisolone45 29 1110.4ITGAM, IL1RN, PTHLH, RNASE3, SELL
25fibrinogen458.3PLA2G7, IL1RN, ITGAM, ELANE, RNASE3, SFTPB
26aspirin45 51 29 2411.3IL1RN, PLA2G7, ITGAM, ELANE, RNASE3, SELL
27fmlp458.3IL8, SELL, RNASE3, ELANE, ITGAM, IL1RN
28hydrocortisone45 3 61 1111.3ELANE, IL1RN, PTHLH, IL8
29progesterone45 29 61 24 1112.2PLA2G7, SCGB1A1, IL1RN, PTHLH, SFTPB, RBP4
30h2o2458.1ELANE, IL8, IL1RN, RNASE3, SELL, ITGAM
31superoxide45 249.0SELL, IL8, PLA2G7, ITGAM, IL1RN, ELANE
32simvastatin45 51 61 29 24 1113.0PTHLH, RBP4, IL1RN, ITGAM, SELL, IL8
33adenylate457.9RBP4, ITGAM, ELANE, RNASE3, PTHLH, IL1RN
34cyclosporin a45 29 619.9ITGAM, RNASE3, IL1RN, ELANE, IL8
35leukotriene b445 61 249.8RNASE3, ELANE, ITGAM, IL1RN, IL8, SELL
36creatinine457.8IL1RN, ITGAM, RNASE3, SELL, PTHLH, SCGB1A1
37estrogen457.7SCGB1A1, RBP4, PLA2G7, ELANE, RNASE3, PTHLH
38cycloheximide457.5IL8, PLA2G7, IL1RN, ITGAM, SFTPB, PTHLH
39lipid457.4IL1RN, PLA2G7, PTHLH, SCGB1A1, SFTPB, ITGAM
40vegf457.3RNASE3, SELL, PTHLH, SFTPB, IL8, FGF10
41nitric oxide45 24 119.2PTHLH, SFTPB, SCGB1A1, RNASE3, ITGAM, PLA2G7
42lactate457.2IL8, SELL, PTHLH, RBP4, RNASE3, ELANE
43calcium45 51 24 1110.1SFTPB, RBP4, IL1RN, PTHLH, RNASE3, ITGAM
44heparin45 29 24 1110.0FGF10, IL8, IL1RN, ELANE, RNASE3, SELL
45retinoic acid45 248.0IL1RN, FGF10, ELANE, RBP4, ITGAM, SFTPB
46dexamethasone45 51 29 1110.0ITGAM, PLA2G7, IL8, IL1RN, RNASE3, SELL
47pge2456.7ITGAM, PLA2G7, IL8, IL1RN, ELANE, RNASE3
48serine456.7ELANE, PTHLH, SFTPB, IL8, RBP4, ITGAM
49endotoxin456.6PLA2G7, SCGB1A1, SELL, RNASE3, ELANE, ITGAM
50oxygen45 247.4IL8, PTHLH, SCGB1A1, SELL, ELANE, ITGAM

GO Terms for genes affiliated with Bronchopulmonary Dysplasia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.2PTHLH, RNASE3, ELANE, IL8, PLA2G7, RBP4
2extracellular spaceGO:0056157.2SFTPB, SCGB1A1, PTHLH, IL1RN, IL8, RBP4

Biological processes related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female genitalia morphogenesisGO:0488079.9FGF10, RBP4
2neutrophil chemotaxisGO:0305939.3IL8, ITGAM
3induction of positive chemotaxisGO:0509309.2FGF10, IL8
4response to lipopolysaccharideGO:0324968.9FGF10, IL1RN, ELANE, SCGB1A1
5female pregnancyGO:0075658.9SCGB1A1, PTHLH, IL1RN
6leukocyte migrationGO:0509008.9ITGAM, ELANE, SELL

Molecular functions related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082018.6FGF10, ITGAM, ELANE, SELL

Products for genes affiliated with Bronchopulmonary Dysplasia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bronchopulmonary Dysplasia

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet