MCID: BRN056
MIFTS: 49

Bronchopulmonary Dysplasia malady

Rare diseases, Respiratory diseases, Fetal diseases categories

Aliases & Classifications for Bronchopulmonary Dysplasia

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Sources:
30LifeMap Discovery®, 41NIH Rare Diseases, 43Novoseek, 47Orphanet, 60UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Bronchopulmonary Dysplasia, Aliases & Descriptions:

Name: Bronchopulmonary Dysplasia 30 41 43 47 60
 
Bpd 41 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

47
bronchopulmonary dysplasia:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Infancy,Neonatal; Age of death: normal life expectancy


External Ids:

Orphanet47 70589
MESH via Orphanet34 D001997
ICD10 via Orphanet26 P27.1
UMLS via Orphanet61 C0006287

Summaries for Bronchopulmonary Dysplasia

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Wikipedia:63 Bronchopulmonary dysplasia (BPD; formerly chronic lung disease of infancy) is a chronic lung disorder of... more...

MalaCards based summary: Bronchopulmonary Dysplasia, also known as bpd, is related to chorioamnionitis and bronchiolitis. An important gene associated with Bronchopulmonary Dysplasia is SFTPB (surfactant protein B), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Selected targets of C EBPalpha. The compounds ozone and curosurf have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and brain, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Related Diseases for Bronchopulmonary Dysplasia

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Diseases related to Bronchopulmonary Dysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis31.0IL1RN, ELANE, IL8
2bronchiolitis30.8RNASE3, IL8
3asthma30.7PLA2G7, SCGB1A1
4atopy30.6SCGB1A1, RNASE3
5respiratory failure30.6SFTPB, SCGB1A1, ITGAM
6bronchiectasis30.2RNASE3, ELANE, IL8
7vascular disease30.2PLA2G7, ITGAM, ELANE
8cystic fibrosis29.2ELANE, SFTPB, IL8, SCGB1A1, RBP4, ITGAM
9pneumonia28.9SCGB1A1, SFTPB, SELL, ELANE, RBP4, PLA2G7
10pulmonary hypertension10.7
11endotheliitis10.6
12malaria10.5RBP4
13meconium aspiration syndrome10.5SFTPB
14conjunctivitis10.5RNASE3
15sinusitis10.5RNASE3
16borderline personality disorder10.5
17personality disorder10.4
18capillary leak syndrome10.4ELANE
19patent ductus arteriosus10.4
20pustulosis palmaris et plantaris10.4ELANE
21hyper-ige recurrent infection syndrome10.4RNASE3, SELL
22leukocyte adhesion deficiency10.4ITGAM
23silicosis10.3SCGB1A1, IL1RN
24leukemoid reaction10.3
25wilson-mikity syndrome10.3
26congenital diaphragmatic hernia10.3FGF10, SFTPB
27synovitis10.3IL8, IL1RN
28common cold10.3RNASE3, IL8
29pulmonary eosinophilia10.3IL8, RNASE3
30arthus reaction10.3SELL, ELANE
31allergic rhinitis10.3IL8, RNASE3
32vernal keratoconjunctivitis10.3RNASE3, IL8
33gastritis10.2IL1RN, IL8
34bronchiolitis obliterans10.2IL8, SCGB1A1
35kawasaki disease10.2ELANE, SELL
36granulocytopenia10.2ITGAM, SELL
37duodenal ulcer10.2IL8, IL1RN
38juvenile rheumatoid arthritis10.2PLA2G7, IL1RN
39nephritis10.2SCGB1A1, IL1RN, RBP4
40pulmonary function10.2
41cerebritis10.2
42funisitis10.2
43cholestasis10.2
44pneumothorax10.2
45hypoxia10.2
46blindness10.2
47lymphopenia10.2IL1RN, SELL
48pulmonary sarcoidosis10.2SELL, ITGAM
49behcet's disease10.2SELL, IL8
50iga glomerulonephritis10.2PLA2G7, SELL, SCGB1A1

Graphical network of the top 20 diseases related to Bronchopulmonary Dysplasia:



Diseases related to bronchopulmonary dysplasia

Symptoms for Bronchopulmonary Dysplasia

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Drugs & Therapeutics for Bronchopulmonary Dysplasia

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Drug clinical trials:

Search ClinicalTrials for Bronchopulmonary Dysplasia

Search NIH Clinical Center for Bronchopulmonary Dysplasia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bronchopulmonary Dysplasia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchopulmonary Dysplasia:
PNEUMOSTEM

Genetic Tests for Bronchopulmonary Dysplasia

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Anatomical Context for Bronchopulmonary Dysplasia

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MalaCards organs/tissues related to Bronchopulmonary Dysplasia:

31
Lung, Endothelial, Brain, Neutrophil, Bone, Testes, Monocytes, Heart, Colon, Kidney, Bone marrow, Placenta, T cells, Fetal lung

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Bronchopulmonary Dysplasia:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Bronchopulmonary Dysplasia or affiliated genes

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MGI Mouse Phenotypes related to Bronchopulmonary Dysplasia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2SFTPB, SCGB1A1, PTHLH, SELL, FGF10
2MP:00053798.0SCGB1A1, PTHLH, SELL, RBP4, FGF10
3MP:00053847.7FGF10, RBP4, IL1RN, ITGAM, SELL, PTHLH
4MP:00053976.9PTHLH, SELL, ELANE, ITGAM, IL1RN, IL8
5MP:00053766.6FGF10, SFTPB, SCGB1A1, PTHLH, SELL, ELANE
6MP:00053876.6SCGB1A1, PTHLH, SELL, ELANE, ITGAM, IL1RN

Publications for Bronchopulmonary Dysplasia

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Articles related to Bronchopulmonary Dysplasia:

(show top 50)    (show all 612)
idTitleAuthorsYear
1
Association between Hemodynamically Significant Patent Ductus Arteriosus and Bronchopulmonary Dysplasia. (25882876)
2015
2
Sildenafil for the Treatment of Pulmonary Arterial Hypertension in Infants with Bronchopulmonary Dysplasia. (25824807)
2015
3
Ventilatory and sensory responses in adult survivors of preterm birth and bronchopulmonary dysplasia with reduced exercise capacity. (25380058)
2014
4
Histologic evidence of intrapulmonary anastomoses by three-dimensional reconstruction in severe bronchopulmonary dysplasia. (23987309)
2013
5
Healthcare utilization and health-related quality of life of adult survivors of preterm birth complicated by bronchopulmonary dysplasia. (23445350)
2013
6
Increased volume of tracheal aspirate fluid predicts the development of bronchopulmonary dysplasia. (22980969)
2013
7
Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins. (23933064)
2013
8
Gene expression profiling in preterm infants: new aspects of bronchopulmonary dysplasia development. (24194948)
2013
9
Ventilatory control in infants, children, and adults with bronchopulmonary dysplasia. (23886637)
2013
10
Azithromycin to prevent bronchopulmonary dysplasia in ureaplasma-infected preterm infants: pharmacokinetics, safety, microbial response, and clinical outcomes with a 20-milligram-per-kilogram single intravenous dose. (23439637)
2013
11
Chorioamnionitis and Bronchopulmonary Dysplasia in Evolution. (24210583)
2013
12
Human umbilical cord blood mononuclear cells in a double-hit model of bronchopulmonary dysplasia in neonatal mice. (24069341)
2013
13
Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia. (22497282)
2012
14
Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia. (22287607)
2012
15
Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension. (22837858)
2012
16
Tension pneumothorax at anaesthetic induction in an ex-premature infant with bronchopulmonary dysplasia. (22967679)
2012
17
Sildenafil therapy for bronchopulmonary dysplasia: not quite yet. (22202953)
2012
18
Nutritional strategies and growth in extremely low birth weight infants with bronchopulmonary dysplasia over the past 10 years. (21617642)
2012
19
A Relationship between Epithelial Maturation, Bronchopulmonary Dysplasia, and Chronic Obstructive Pulmonary Disease. (23320163)
2012
20
High incidence of rickets in extremely low birth weight infants with severe parenteral nutrition-associated cholestasis and bronchopulmonary dysplasia. (23255857)
2012
21
Current pharmacologic approaches for prevention and treatment of bronchopulmonary dysplasia. (22262977)
2012
22
Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. (22328358)
2012
23
Inflammatory cytokines in gastric fluid at birth and the development of bronchopulmonary dysplasia. (21438921)
2011
24
Clarithromycin in preventing bronchopulmonary dysplasia in Ureaplasma urealyticum-positive preterm infants. (22123897)
2011
25
A role for matrix metalloproteinase 9 in IFNI^-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia. (21216975)
2011
26
Nebulized furosemide in the treatment of bronchopulmonary dysplasia in preterm infants. (22477820)
2011
27
The new bronchopulmonary dysplasia. (21169836)
2011
28
Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study); a multicenter randomized placebo controlled trial. (22070744)
2011
29
Genetic and epidemiological risk factors in the development of bronchopulmonary dysplasia. (20826912)
2010
30
Inhaled nitric oxide does not prevent bronchopulmonary dysplasia. (20876257)
2010
31
Neonatal bronchopulmonary dysplasia predicts abnormal pulmonary HRCT scans in long-term survivors of extreme preterm birth. (19158126)
2009
32
Ventilatory management and bronchopulmonary dysplasia in preterm infants. (19766071)
2009
33
Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants. (19204058)
2009
34
Prologue: advances in bronchopulmonary dysplasia. (19782014)
2009
35
Prevention and treatment of bronchopulmonary dysplasia: contemporary status and future outlook. (18228098)
2008
36
Non-invasive positive pressure ventilation in the preterm neonate: reducing endotrauma and the incidence of bronchopulmonary dysplasia. (17768159)
2008
37
Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia. (18330726)
2008
38
Epithelial lining fluid neutrophil-gelatinase-associated lipocalin levels in premature newborns with bronchopulmonary dysplasia and patency of ductus arteriosus. (18336743)
2008
39
Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate. (18676410)
2008
40
Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema. (17394419)
2007
41
FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. (17071719)
2007
42
Ventilatory pump failure and strategies to prevent bronchopulmonary dysplasia. (17606588)
2007
43
Genetic analysis of the dystroglycan gene in bronchopulmonary dysplasia affected premature newborns. (17196572)
2007
44
Does bronchopulmonary dysplasia change the postoperative outcome of herniorrhaphy in premature babies? (17474949)
2007
45
Reduction of bronchopulmonary dysplasia after participation in the Breathsavers Group of the Vermont Oxford Network Neonatal Intensive Care Quality Improvement Collaborative. (17079626)
2006
46
Bronchopulmonary dysplasia in very low birth weight infants is associated with prolonged hospital stay. (17006525)
2006
47
Monocyte chemoattractant protein-1 and interleukin-8 are increased in bronchopulmonary dysplasia: relation to isolation of Ureaplasma urealyticum. (11478413)
2001
48
Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. (9369827)
1997
49
Elevation of interleukin-8 and interleukin-6 precedes the influx of neutrophils in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. (9407566)
1997
50
Immunohistochemical study of copper-zinc and manganese superoxide dismutases in the lungs of human fetuses and newborn infants: developmental profile and alterations in hyaline membrane disease and bronchopulmonary dysplasia. (8236811)
1993

Variations for Bronchopulmonary Dysplasia

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Expression for genes affiliated with Bronchopulmonary Dysplasia

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Search GEO for disease gene expression data for Bronchopulmonary Dysplasia.

Pathways for genes affiliated with Bronchopulmonary Dysplasia

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Pathways related to Bronchopulmonary Dysplasia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SELL, ELANE
29.3ELANE, ITGAM
39.3IL8, ITGAM
48.8IL8, ITGAM, ELANE

Compounds for genes affiliated with Bronchopulmonary Dysplasia

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Compounds related to Bronchopulmonary Dysplasia according to GeneCards Suite gene sharing:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1ozone439.7SCGB1A1, RNASE3, SFTPB
2curosurf439.5SFTPB, IL8, ELANE
3survanta439.5IL8, ELANE, SFTPB
4filgrastim43 1210.2ITGAM, ELANE, IL1RN
5phorbol439.1ITGAM, RNASE3, RBP4, SELL
6zymosan439.1ELANE, ITGAM, IL1RN, RNASE3
7cuprophan439.1IL1RN, ITGAM, ELANE, SELL
8polysulfone439.0IL1RN, ITGAM, ELANE, SELL
9montelukast43 49 28 1212.0RNASE3, IL8, ITGAM
10vitamin a43 24 1211.0RBP4, IL1RN, ELANE, SCGB1A1, SFTPB
11latex438.9ITGAM, RBP4, IL1RN, RNASE3, SCGB1A1
12aebsf438.9ELANE, PLA2G7, IL8
13atorvastatin43 49 28 24 1212.8SELL, ITGAM, IL1RN, PLA2G7
14rolipram43 59 2810.8ITGAM, SELL, ELANE, IL8
15hyaluronic acid43 249.8RNASE3, IL1RN, ELANE, SCGB1A1, IL8
16rantes438.7RNASE3, ITGAM, IL1RN, IL8, SELL
17epinephrine43 24 1210.7ITGAM, SELL, RNASE3, ELANE, IL1RN
18n-formylmethionyl-leucylphenylalanine438.6SELL, RNASE3, ELANE, ITGAM, IL8
19histamine43 28 2410.6RNASE3, SELL, IL1RN, ITGAM, IL8
20pentoxifylline43 129.6SELL, ELANE, ITGAM, IL1RN, IL8
21aprotinin43 129.5ELANE, IL8, PTHLH, SELL
22p002438.5ITGAM, RBP4, PLA2G7, IL1RN, RNASE3, SCGB1A1
23phospholipid438.5RBP4, PLA2G7, SCGB1A1, SFTPB, PTHLH
24prednisolone43 28 1210.4ITGAM, IL1RN, PTHLH, RNASE3, SELL
25fibrinogen438.3PLA2G7, IL1RN, ITGAM, ELANE, RNASE3, SFTPB
26aspirin43 49 28 2411.3IL1RN, PLA2G7, ITGAM, ELANE, RNASE3, SELL
27fmlp438.3IL8, SELL, RNASE3, ELANE, ITGAM, IL1RN
28hydrocortisone43 2 59 1211.3ELANE, IL1RN, PTHLH, IL8
29progesterone43 28 59 24 1212.2PLA2G7, SCGB1A1, IL1RN, PTHLH, SFTPB, RBP4
30h2o2438.1ELANE, IL8, IL1RN, RNASE3, SELL, ITGAM
31superoxide43 249.0SELL, IL8, PLA2G7, ITGAM, IL1RN, ELANE
32simvastatin43 49 59 28 24 1213.0PTHLH, RBP4, IL1RN, ITGAM, SELL, IL8
33adenylate437.9RBP4, ITGAM, ELANE, RNASE3, PTHLH, IL1RN
34cyclosporin a43 28 599.9ITGAM, RNASE3, IL1RN, ELANE, IL8
35leukotriene b443 59 249.8RNASE3, ELANE, ITGAM, IL1RN, IL8, SELL
36creatinine437.8IL1RN, ITGAM, RNASE3, SELL, PTHLH, SCGB1A1
37estrogen437.7SCGB1A1, RBP4, PLA2G7, ELANE, RNASE3, PTHLH
38cycloheximide437.5IL8, PLA2G7, IL1RN, ITGAM, SFTPB, PTHLH
39lipid437.4IL1RN, PLA2G7, PTHLH, SCGB1A1, SFTPB, ITGAM
40vegf437.3RNASE3, SELL, PTHLH, SFTPB, IL8, FGF10
41nitric oxide43 24 129.2PTHLH, SFTPB, SCGB1A1, RNASE3, ITGAM, PLA2G7
42lactate437.2IL8, SELL, PTHLH, RBP4, RNASE3, ELANE
43calcium43 49 24 1210.1SFTPB, RBP4, IL1RN, PTHLH, RNASE3, ITGAM
44heparin43 28 24 1210.0FGF10, IL8, IL1RN, ELANE, RNASE3, SELL
45retinoic acid43 248.0IL1RN, FGF10, ELANE, RBP4, ITGAM, SFTPB
46dexamethasone43 49 28 1210.0ITGAM, PLA2G7, IL8, IL1RN, RNASE3, SELL
47pge2436.7ITGAM, PLA2G7, IL8, IL1RN, ELANE, RNASE3
48serine436.7ELANE, PTHLH, SFTPB, IL8, RBP4, ITGAM
49endotoxin436.6PLA2G7, SCGB1A1, SELL, RNASE3, ELANE, ITGAM
50oxygen43 247.4IL8, PTHLH, SCGB1A1, SELL, ELANE, ITGAM

GO Terms for genes affiliated with Bronchopulmonary Dysplasia

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Cellular components related to Bronchopulmonary Dysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.2PTHLH, RNASE3, ELANE, IL8, PLA2G7, RBP4
2extracellular spaceGO:00056157.2SFTPB, SCGB1A1, PTHLH, IL1RN, IL8, RBP4

Biological processes related to Bronchopulmonary Dysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1female genitalia morphogenesisGO:00488079.9RBP4, FGF10
2neutrophil chemotaxisGO:00305939.3ITGAM, IL8
3induction of positive chemotaxisGO:00509309.2FGF10, IL8
4response to lipopolysaccharideGO:00324968.9SCGB1A1, ELANE, FGF10, IL1RN
5female pregnancyGO:00075658.9IL1RN, SCGB1A1, PTHLH
6leukocyte migrationGO:00509008.9ITGAM, ELANE, SELL

Molecular functions related to Bronchopulmonary Dysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082018.6FGF10, ITGAM, ELANE, SELL

Products for genes affiliated with Bronchopulmonary Dysplasia

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Sources for Bronchopulmonary Dysplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet