BPD
MCID: BRN056
MIFTS: 57

Bronchopulmonary Dysplasia (BPD) malady

Rare diseases, Respiratory diseases, Fetal diseases categories
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Summaries for Bronchopulmonary Dysplasia

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Wikipedia:65 Bronchopulmonary dysplasia (BPD; formerly chronic lung disease of infancy) is a chronic lung disorder... more...

MalaCards based summary: Bronchopulmonary Dysplasia, also known as BPD, is related to chorioamnionitis and bronchiolitis. An important gene associated with Bronchopulmonary Dysplasia is SFTPB (surfactant protein B), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Selected targets of C EBPalpha. The compounds ozone and curosurf have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and brain, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Classifications for Bronchopulmonary Dysplasia

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Sources:
30LifeMap Discovery®, 42NIH Rare Diseases, 44Novoseek, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Bronchopulmonary Dysplasia, Aliases & Descriptions:

Name: Bronchopulmonary Dysplasia 30 42 44 48 62
 
Bpd 42 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
bronchopulmonary dysplasia:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy; Age of death: Normal


External Ids:

MESH via Orphanet35 D001997
ICD10 via Orphanet26 P27.1
UMLS via Orphanet63 C0006287

Related Diseases for Bronchopulmonary Dysplasia

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Diseases related to Bronchopulmonary Dysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis31.0IL1RN, ELANE, IL8
2bronchiolitis30.8RNASE3, IL8
3asthma30.8PLA2G7, SCGB1A1
4atopy30.7SCGB1A1, RNASE3
5respiratory failure30.6SFTPB, SCGB1A1, ITGAM
6bronchiectasis30.2RNASE3, ELANE, IL8
7vascular disease30.2PLA2G7, ITGAM, ELANE
8chronic obstructive pulmonary disease29.4IL8, SFTPB, ELANE, RNASE3, SCGB1A1, ITGAM
9cystic fibrosis29.2ELANE, SFTPB, IL8, SCGB1A1, RBP4, ITGAM
10sepsis29.1RBP4, IL1RN, ITGAM, ELANE, IL8, PLA2G7
11pneumonia28.9SCGB1A1, SFTPB, SELL, ELANE, RBP4, PLA2G7
12hypertension10.8
13pulmonary hypertension10.7
14endotheliitis10.6
15malaria10.5RBP4
16meconium aspiration syndrome10.5SFTPB
17conjunctivitis10.5RNASE3
18sinusitis10.5RNASE3
19borderline personality disorder10.5
20personality disorder10.4
21capillary leak syndrome10.4ELANE
22pustulosis palmaris et plantaris10.4ELANE
23autosomal dominant hyper ige syndrome10.4RNASE3, SELL
24patent ductus arteriosus10.4
25leukocyte adhesion deficiency10.4ITGAM
26silicosis10.3SCGB1A1, IL1RN
27retinopathy of prematurity10.3
28leukemoid reaction10.3
29wilson-mikity syndrome10.3
30congenital diaphragmatic hernia10.3FGF10, SFTPB
31synovitis10.3IL8, IL1RN
32common cold10.3RNASE3, IL8
33pulmonary eosinophilia10.3IL8, RNASE3
34arthus reaction10.3SELL, ELANE
35allergic rhinitis10.3IL8, RNASE3
36vernal keratoconjunctivitis10.3RNASE3, IL8
37gastritis10.2IL1RN, IL8
38bronchiolitis obliterans10.2IL8, SCGB1A1
39kawasaki disease10.2ELANE, SELL
40duodenal ulcer10.2IL8, IL1RN
41juvenile rheumatoid arthritis10.2PLA2G7, IL1RN
42nephritis10.2SCGB1A1, IL1RN, RBP4
43sandhoff disease10.2
44funisitis10.2
45cerebritis10.2
46cholestasis10.2
47pneumothorax10.2
48hypoxia10.2
49pulmonary function10.2
50blindness10.2

Graphical network of the top 20 diseases related to Bronchopulmonary Dysplasia:



Diseases related to bronchopulmonary dysplasia

Symptoms for Bronchopulmonary Dysplasia

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Drugs & Therapeutics for Bronchopulmonary Dysplasia

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Drug clinical trials:

Search ClinicalTrials for Bronchopulmonary Dysplasia

Search NIH Clinical Center for Bronchopulmonary Dysplasia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bronchopulmonary Dysplasia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchopulmonary Dysplasia:
PNEUMOSTEM

Genetic Tests for Bronchopulmonary Dysplasia

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Anatomical Context for Bronchopulmonary Dysplasia

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MalaCards organs/tissues related to Bronchopulmonary Dysplasia:

32
Lung, Endothelial, Brain, Neutrophil, Testes, Monocytes, Bone, Bone marrow, Heart, Colon, Placenta, Fetal lung

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bronchopulmonary Dysplasia:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Bronchopulmonary Dysplasia or affiliated genes

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MGI Mouse Phenotypes related to Bronchopulmonary Dysplasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2SFTPB, SCGB1A1, PTHLH, SELL, FGF10
2MP:00053798.0SCGB1A1, PTHLH, SELL, RBP4, FGF10
3MP:00053847.7FGF10, RBP4, IL1RN, ITGAM, SELL, PTHLH
4MP:00053976.9PTHLH, SELL, ELANE, ITGAM, IL1RN, IL8
5MP:00053766.6FGF10, SFTPB, SCGB1A1, PTHLH, SELL, ELANE
6MP:00053876.6SCGB1A1, PTHLH, SELL, ELANE, ITGAM, IL1RN

Publications for Bronchopulmonary Dysplasia

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Articles related to Bronchopulmonary Dysplasia:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Ventilatory and sensory responses in adult survivors of preterm birth and bronchopulmonary dysplasia with reduced exercise capacity. (25380058)
2014
2
Histologic evidence of intrapulmonary anastomoses by three-dimensional reconstruction in severe bronchopulmonary dysplasia. (23987309)
2013
3
Healthcare utilization and health-related quality of life of adult survivors of preterm birth complicated by bronchopulmonary dysplasia. (23445350)
2013
4
Increased volume of tracheal aspirate fluid predicts the development of bronchopulmonary dysplasia. (22980969)
2013
5
Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins. (23933064)
2013
6
Gene expression profiling in preterm infants: new aspects of bronchopulmonary dysplasia development. (24194948)
2013
7
Ventilatory control in infants, children, and adults with bronchopulmonary dysplasia. (23886637)
2013
8
Azithromycin to prevent bronchopulmonary dysplasia in ureaplasma-infected preterm infants: pharmacokinetics, safety, microbial response, and clinical outcomes with a 20-milligram-per-kilogram single intravenous dose. (23439637)
2013
9
Chorioamnionitis and Bronchopulmonary Dysplasia in Evolution. (24210583)
2013
10
Human umbilical cord blood mononuclear cells in a double-hit model of bronchopulmonary dysplasia in neonatal mice. (24069341)
2013
11
B-type natriuretic peptide levels in preterm neonates with bronchopulmonary dysplasia: A marker of severity? (24214578)
2013
12
Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia. (22497282)
2012
13
Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia. (22287607)
2012
14
Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension. (22837858)
2012
15
Tension pneumothorax at anaesthetic induction in an ex-premature infant with bronchopulmonary dysplasia. (22967679)
2012
16
Sildenafil therapy for bronchopulmonary dysplasia: not quite yet. (22202953)
2012
17
Nutritional strategies and growth in extremely low birth weight infants with bronchopulmonary dysplasia over the past 10 years. (21617642)
2012
18
A Relationship between Epithelial Maturation, Bronchopulmonary Dysplasia, and Chronic Obstructive Pulmonary Disease. (23320163)
2012
19
High incidence of rickets in extremely low birth weight infants with severe parenteral nutrition-associated cholestasis and bronchopulmonary dysplasia. (23255857)
2012
20
Current pharmacologic approaches for prevention and treatment of bronchopulmonary dysplasia. (22262977)
2012
21
Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. (22328358)
2012
22
Inflammatory cytokines in gastric fluid at birth and the development of bronchopulmonary dysplasia. (21438921)
2011
23
Clarithromycin in preventing bronchopulmonary dysplasia in Ureaplasma urealyticum-positive preterm infants. (22123897)
2011
24
A role for matrix metalloproteinase 9 in IFNI^-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia. (21216975)
2011
25
Nebulized furosemide in the treatment of bronchopulmonary dysplasia in preterm infants. (22477820)
2011
26
The new bronchopulmonary dysplasia. (21169836)
2011
27
Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study); a multicenter randomized placebo controlled trial. (22070744)
2011
28
Genetic and epidemiological risk factors in the development of bronchopulmonary dysplasia. (20826912)
2010
29
Inhaled nitric oxide does not prevent bronchopulmonary dysplasia. (20876257)
2010
30
Policy statement--postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia. (20819899)
2010
31
Neonatal bronchopulmonary dysplasia predicts abnormal pulmonary HRCT scans in long-term survivors of extreme preterm birth. (19158126)
2009
32
Ventilatory management and bronchopulmonary dysplasia in preterm infants. (19766071)
2009
33
Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants. (19204058)
2009
34
Prologue: advances in bronchopulmonary dysplasia. (19782014)
2009
35
Prevention and treatment of bronchopulmonary dysplasia: contemporary status and future outlook. (18228098)
2008
36
Non-invasive positive pressure ventilation in the preterm neonate: reducing endotrauma and the incidence of bronchopulmonary dysplasia. (17768159)
2008
37
Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia. (18330726)
2008
38
Epithelial lining fluid neutrophil-gelatinase-associated lipocalin levels in premature newborns with bronchopulmonary dysplasia and patency of ductus arteriosus. (18336743)
2008
39
Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate. (18676410)
2008
40
Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema. (17394419)
2007
41
FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. (17071719)
2007
42
Ventilatory pump failure and strategies to prevent bronchopulmonary dysplasia. (17606588)
2007
43
Genetic analysis of the dystroglycan gene in bronchopulmonary dysplasia affected premature newborns. (17196572)
2007
44
Does bronchopulmonary dysplasia change the postoperative outcome of herniorrhaphy in premature babies? (17474949)
2007
45
Reduction of bronchopulmonary dysplasia after participation in the Breathsavers Group of the Vermont Oxford Network Neonatal Intensive Care Quality Improvement Collaborative. (17079626)
2006
46
Bronchopulmonary dysplasia in very low birth weight infants is associated with prolonged hospital stay. (17006525)
2006
47
Monocyte chemoattractant protein-1 and interleukin-8 are increased in bronchopulmonary dysplasia: relation to isolation of Ureaplasma urealyticum. (11478413)
2001
48
Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. (9369827)
1997
49
Elevation of interleukin-8 and interleukin-6 precedes the influx of neutrophils in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. (9407566)
1997
50
Immunohistochemical study of copper-zinc and manganese superoxide dismutases in the lungs of human fetuses and newborn infants: developmental profile and alterations in hyaline membrane disease and bronchopulmonary dysplasia. (8236811)
1993

Variations for Bronchopulmonary Dysplasia

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Expression for genes affiliated with Bronchopulmonary Dysplasia

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Expression patterns in normal tissues for genes affiliated with Bronchopulmonary Dysplasia

Search GEO for disease gene expression data for Bronchopulmonary Dysplasia.

Pathways for genes affiliated with Bronchopulmonary Dysplasia

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Pathways related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SELL, ELANE
29.6SCGB1A1, ELANE
39.3ELANE, ITGAM
49.3IL8, ITGAM
58.8IL8, ITGAM, ELANE

Compounds for genes affiliated with Bronchopulmonary Dysplasia

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Compounds related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1ozone449.7SFTPB, SCGB1A1, RNASE3
2curosurf449.5SFTPB, ELANE, IL8
3survanta449.5SFTPB, ELANE, IL8
4filgrastim44 1110.2ELANE, ITGAM, IL1RN
5phorbol449.1RBP4, ITGAM, RNASE3, SELL
6zymosan449.1RNASE3, ELANE, ITGAM, IL1RN
7cuprophan449.1SELL, ELANE, ITGAM, IL1RN
8polysulfone449.0SELL, ELANE, ITGAM, IL1RN
9montelukast44 50 28 1112.0IL8, ITGAM, RNASE3
10vitamin a44 24 1111.0SFTPB, SCGB1A1, ELANE, IL1RN, RBP4
11latex448.9RBP4, IL1RN, ITGAM, RNASE3, SCGB1A1
12aebsf448.9ELANE, IL8, PLA2G7
13atorvastatin44 50 28 24 1112.8SELL, ITGAM, IL1RN, PLA2G7
14rolipram44 61 2810.8SELL, ELANE, ITGAM, IL8
15hyaluronic acid44 249.8IL8, IL1RN, ELANE, RNASE3, SCGB1A1
16rantes448.7SELL, RNASE3, ITGAM, IL1RN, IL8
17epinephrine44 24 1110.7SELL, RNASE3, ELANE, ITGAM, IL1RN
18n-formylmethionyl-leucylphenylalanine448.6SELL, RNASE3, ELANE, ITGAM, IL8
19histamine44 28 2410.6SELL, RNASE3, ITGAM, IL1RN, IL8
20pentoxifylline44 119.6SELL, ELANE, ITGAM, IL1RN, IL8
21aprotinin44 119.5IL8, ELANE, SELL, PTHLH
22p002448.5SCGB1A1, RNASE3, ITGAM, IL1RN, PLA2G7, RBP4
23phospholipid448.5SFTPB, SCGB1A1, PTHLH, PLA2G7, RBP4
24prednisolone44 28 1110.4IL1RN, ITGAM, RNASE3, SELL, PTHLH
25fibrinogen448.3SFTPB, RNASE3, ELANE, ITGAM, IL1RN, PLA2G7
26aspirin44 50 28 2411.3SELL, RNASE3, ELANE, ITGAM, IL1RN, PLA2G7
27fmlp448.3SELL, RNASE3, ELANE, ITGAM, IL1RN, IL8
28hydrocortisone44 2 61 1111.3IL8, IL1RN, ELANE, PTHLH
29progesterone44 28 61 24 1112.2SFTPB, SCGB1A1, PTHLH, IL1RN, PLA2G7, RBP4
30h2o2448.1SELL, RNASE3, ELANE, ITGAM, IL1RN, IL8
31superoxide44 249.0SELL, ELANE, ITGAM, IL1RN, IL8, PLA2G7
32simvastatin44 50 61 28 24 1113.0PTHLH, SELL, ITGAM, IL1RN, IL8, RBP4
33adenylate447.9PTHLH, RNASE3, ELANE, ITGAM, IL1RN, RBP4
34cyclosporin a44 28 619.9IL8, IL1RN, ITGAM, ELANE, RNASE3
35leukotriene b444 61 249.8SELL, RNASE3, ELANE, ITGAM, IL1RN, IL8
36creatinine447.8SCGB1A1, PTHLH, SELL, RNASE3, ITGAM, IL1RN
37estrogen447.7SCGB1A1, PTHLH, RNASE3, ELANE, IL1RN, PLA2G7
38cycloheximide447.5SFTPB, PTHLH, SELL, ITGAM, IL1RN, IL8
39lipid447.4SFTPB, SCGB1A1, PTHLH, RNASE3, ITGAM, IL1RN
40vegf447.3SFTPB, PTHLH, SELL, RNASE3, ITGAM, IL1RN
41nitric oxide44 24 119.2SFTPB, SCGB1A1, PTHLH, RNASE3, ITGAM, IL1RN
42lactate447.2PTHLH, SELL, RNASE3, ELANE, ITGAM, IL1RN
43calcium44 50 24 1110.1SFTPB, SCGB1A1, PTHLH, RNASE3, ITGAM, IL1RN
44heparin44 28 24 1110.0PTHLH, SELL, RNASE3, ELANE, ITGAM, IL1RN
45retinoic acid44 248.0SFTPB, PTHLH, SELL, RNASE3, ELANE, ITGAM
46dexamethasone44 50 28 1110.0SFTPB, PTHLH, SELL, RNASE3, ITGAM, IL1RN
47pge2446.7SFTPB, PTHLH, SELL, RNASE3, ELANE, ITGAM
48serine446.7SFTPB, PTHLH, SELL, ELANE, ITGAM, IL1RN
49endotoxin446.6PLA2G7, SCGB1A1, PTHLH, SELL, RNASE3, ELANE
50oxygen44 247.4SFTPB, SCGB1A1, PTHLH, SELL, ELANE, ITGAM

GO Terms for genes affiliated with Bronchopulmonary Dysplasia

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Cellular components related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.2PTHLH, RNASE3, ELANE, IL8, PLA2G7, RBP4
2extracellular spaceGO:0056157.2SFTPB, SCGB1A1, PTHLH, IL1RN, IL8, RBP4

Biological processes related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female genitalia morphogenesisGO:0488079.9RBP4, FGF10
2neutrophil chemotaxisGO:0305939.3ITGAM, IL8
3induction of positive chemotaxisGO:0509309.2FGF10, IL8
4response to lipopolysaccharideGO:0324968.9SCGB1A1, ELANE, FGF10, IL1RN
5female pregnancyGO:0075658.9IL1RN, SCGB1A1, PTHLH
6leukocyte migrationGO:0509008.9ITGAM, ELANE, SELL

Molecular functions related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082018.6FGF10, ITGAM, ELANE, SELL

Products for genes affiliated with Bronchopulmonary Dysplasia

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Sources for Bronchopulmonary Dysplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet