BPD
MCID: BRN056
MIFTS: 56

Bronchopulmonary Dysplasia (BPD) malady

Rare diseases, Respiratory diseases, Fetal diseases categories

Summaries for Bronchopulmonary Dysplasia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Bronchopulmonary dysplasia (BPD; formerly chronic lung disease of infancy) is a chronic lung disorder... more...

MalaCards: Bronchopulmonary Dysplasia, also known as BPD, is related to chorioamnionitis and respiratory failure. An important gene associated with Bronchopulmonary Dysplasia is SFTPB (surfactant protein B), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Selected targets of C EBPalpha. The compounds ozone and curosurf have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and brain, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Classifications for Bronchopulmonary Dysplasia

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44NIH Rare Diseases, 46Novoseek, 50Orphanet, 32LifeMap Discoveryā„¢, 63UMLS, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

50
bronchopulmonary dysplasia:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy; Age of death: Normal


Aliases & Descriptions:

bronchopulmonary dysplasia 44 46 50 32 63
bpd 44 50


External Ids:

MESH via Orphanet37 D001997
ICD10 via Orphanet27 P27.1
SNOMED-CT via Orphanet60 67569000
UMLS via Orphanet64 C0006287

Related Diseases for Bronchopulmonary Dysplasia

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18GeneCards, 19GeneDecks
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Diseases related to Bronchopulmonary Dysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.8IL1RN, ELANE, IL8
2respiratory failure30.5SFTPB, SCGB1A1, ITGAM
3bronchiolitis30.4RNASE3, IL8
4asthma30.4PLA2G7, SCGB1A1
5atopy30.2SCGB1A1, RNASE3
6bronchiectasis30.1RNASE3, ELANE, IL8
7vascular disease30.0PLA2G7, ITGAM, ELANE
8cystic fibrosis29.9ELANE, SFTPB, IL8, SCGB1A1, RBP4, ITGAM
9pneumonia29.8SCGB1A1, SFTPB, SELL, ELANE, RBP4, PLA2G7
10hypertension10.7
11endotheliitis10.6
12borderline personality disorder10.4
13personality disorder10.4
14patent ductus arteriosus10.3
15leukemoid reaction10.3
16retinopathy of prematurity10.3
17wilson-mikity syndrome10.3
18sandhoff disease10.2
19cerebritis10.2
20funisitis10.2
21cholestasis10.2
22pneumothorax10.2
23hypoxia10.2
24pulmonary function10.2
25blindness10.2
26malaria10.1RBP4
27meconium aspiration syndrome10.1SFTPB
28conjunctivitis10.1RNASE3
29sinusitis10.1RNASE3
30capillary leak syndrome10.1ELANE
31pustulosis palmaris et plantaris10.1ELANE
32autosomal dominant hyper ige syndrome10.1RNASE3, SELL
33leukocyte adhesion deficiency10.1ITGAM
34silicosis10.1SCGB1A1, IL1RN
35congenital diaphragmatic hernia10.1FGF10, SFTPB
36synovitis10.1IL8, IL1RN
37common cold10.1RNASE3, IL8
38pulmonary eosinophilia10.1IL8, RNASE3
39arthus reaction10.1SELL, ELANE
40allergic rhinitis10.1IL8, RNASE3
41vernal keratoconjunctivitis10.1RNASE3, IL8
42gastritis10.1IL1RN, IL8
43bronchiolitis obliterans10.1IL8, SCGB1A1
44kawasaki disease10.1ELANE, SELL
45duodenal ulcer10.1IL8, IL1RN
46juvenile rheumatoid arthritis10.1PLA2G7, IL1RN
47nephritis10.1SCGB1A1, IL1RN, RBP4
48rickets10.0
49gastroesophageal reflux disease10.0
50interstitial emphysema10.0

Graphical network of the top 20 diseases related to Bronchopulmonary Dysplasia:



Diseases related to bronchopulmonary dysplasia

Symptoms for Bronchopulmonary Dysplasia

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Drugs & Therapeutics for Bronchopulmonary Dysplasia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Bronchopulmonary Dysplasia

Drug clinical trials:

Search ClinicalTrials for Bronchopulmonary Dysplasia

Search NIH Clinical Center for Bronchopulmonary Dysplasia

Search CenterWatch for Bronchopulmonary Dysplasia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Bronchopulmonary Dysplasia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchopulmonary Dysplasia:
PNEUMOSTEM

Genetic Tests for Bronchopulmonary Dysplasia

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Anatomical Context for Bronchopulmonary Dysplasia

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Bronchopulmonary Dysplasia:

34
Lung, Endothelial, Brain, Testes, Monocytes, Bone, Colon, Placenta, Heart, Bone marrow, Fetal lung

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Bronchopulmonary Dysplasia:
id TissueAnatomical CompartmentCell Relevance
1 LungAlveoliAlveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 LungAlveoliAlveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 LungPulmonary Capillary Plexus  Affected by disease

Animal Models for Bronchopulmonary Dysplasia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Bronchopulmonary Dysplasia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2SFTPB, SCGB1A1, PTHLH, SELL, FGF10
2MP:00053798.0SCGB1A1, PTHLH, SELL, RBP4, FGF10
3MP:00053847.7FGF10, RBP4, IL1RN, ITGAM, SELL, PTHLH
4MP:00053976.9PTHLH, SELL, ELANE, ITGAM, IL1RN, IL8
5MP:00053766.6FGF10, SFTPB, SCGB1A1, PTHLH, SELL, ELANE
6MP:00053876.6SCGB1A1, PTHLH, SELL, ELANE, ITGAM, IL1RN

Publications for Bronchopulmonary Dysplasia

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53PubMed
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Articles related to Bronchopulmonary Dysplasia:

(show top 50)    (show all 564)
idTitleAuthorsYear
1
Healthcare utilization and health-related quality of life of adult survivors of preterm birth complicated by bronchopulmonary dysplasia. (23445350)
2013
2
Increased volume of tracheal aspirate fluid predicts the development of bronchopulmonary dysplasia. (22980969)
2013
3
Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins. (23933064)
2013
4
Gene expression profiling in preterm infants: new aspects of bronchopulmonary dysplasia development. (24194948)
2013
5
Ventilatory control in infants, children, and adults with bronchopulmonary dysplasia. (23886637)
2013
6
Azithromycin to prevent bronchopulmonary dysplasia in ureaplasma-infected preterm infants: pharmacokinetics, safety, microbial response, and clinical outcomes with a 20-milligram-per-kilogram single intravenous dose. (23439637)
2013
7
Chorioamnionitis and Bronchopulmonary Dysplasia in Evolution. (24210583)
2013
8
Human umbilical cord blood mononuclear cells in a double-hit model of bronchopulmonary dysplasia in neonatal mice. (24069341)
2013
9
B-type natriuretic peptide levels in preterm neonates with bronchopulmonary dysplasia: A marker of severity? (24214578)
2013
10
MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. (24301780)
2013
11
Bronchopulmonary dysplasia: a review. (23420126)
2013
12
Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia. (22497282)
2012
13
Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia. (22287607)
2012
14
Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension. (22837858)
2012
15
Tension pneumothorax at anaesthetic induction in an ex-premature infant with bronchopulmonary dysplasia. (22967679)
2012
16
Sildenafil therapy for bronchopulmonary dysplasia: not quite yet. (22202953)
2012
17
Nutritional strategies and growth in extremely low birth weight infants with bronchopulmonary dysplasia over the past 10 years. (21617642)
2012
18
A Relationship between Epithelial Maturation, Bronchopulmonary Dysplasia, and Chronic Obstructive Pulmonary Disease. (23320163)
2012
19
High incidence of rickets in extremely low birth weight infants with severe parenteral nutrition-associated cholestasis and bronchopulmonary dysplasia. (23255857)
2012
20
Current pharmacologic approaches for prevention and treatment of bronchopulmonary dysplasia. (22262977)
2012
21
Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. (22328358)
2012
22
Inflammatory cytokines in gastric fluid at birth and the development of bronchopulmonary dysplasia. (21438921)
2011
23
Clarithromycin in preventing bronchopulmonary dysplasia in Ureaplasma urealyticum-positive preterm infants. (22123897)
2011
24
A role for matrix metalloproteinase 9 in IFNI^-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia. (21216975)
2011
25
Nebulized furosemide in the treatment of bronchopulmonary dysplasia in preterm infants. (22477820)
2011
26
The new bronchopulmonary dysplasia. (21169836)
2011
27
Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study); a multicenter randomized placebo controlled trial. (22070744)
2011
28
Genetic and epidemiological risk factors in the development of bronchopulmonary dysplasia. (20826912)
2010
29
Inhaled nitric oxide does not prevent bronchopulmonary dysplasia. (20876257)
2010
30
Policy statement--postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia. (20819899)
2010
31
Neonatal bronchopulmonary dysplasia predicts abnormal pulmonary HRCT scans in long-term survivors of extreme preterm birth. (19158126)
2009
32
Ventilatory management and bronchopulmonary dysplasia in preterm infants. (19766071)
2009
33
Impact of postnatal corticosteroid use on neurodevelopment at 18 to 22 months' adjusted age: effects of dose, timing, and risk of bronchopulmonary dysplasia in extremely low birth weight infants. (19204058)
2009
34
Prologue: advances in bronchopulmonary dysplasia. (19782014)
2009
35
Prevention and treatment of bronchopulmonary dysplasia: contemporary status and future outlook. (18228098)
2008
36
Non-invasive positive pressure ventilation in the preterm neonate: reducing endotrauma and the incidence of bronchopulmonary dysplasia. (17768159)
2008
37
Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia. (18330726)
2008
38
Epithelial lining fluid neutrophil-gelatinase-associated lipocalin levels in premature newborns with bronchopulmonary dysplasia and patency of ductus arteriosus. (18336743)
2008
39
Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate. (18676410)
2008
40
Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema. (17394419)
2007
41
FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. (17071719)
2007
42
Ventilatory pump failure and strategies to prevent bronchopulmonary dysplasia. (17606588)
2007
43
Genetic analysis of the dystroglycan gene in bronchopulmonary dysplasia affected premature newborns. (17196572)
2007
44
Does bronchopulmonary dysplasia change the postoperative outcome of herniorrhaphy in premature babies? (17474949)
2007
45
Reduction of bronchopulmonary dysplasia after participation in the Breathsavers Group of the Vermont Oxford Network Neonatal Intensive Care Quality Improvement Collaborative. (17079626)
2006
46
Bronchopulmonary dysplasia in very low birth weight infants is associated with prolonged hospital stay. (17006525)
2006
47
Monocyte chemoattractant protein-1 and interleukin-8 are increased in bronchopulmonary dysplasia: relation to isolation of Ureaplasma urealyticum. (11478413)
2001
48
Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. (9369827)
1997
49
Elevation of interleukin-8 and interleukin-6 precedes the influx of neutrophils in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. (9407566)
1997
50
Immunohistochemical study of copper-zinc and manganese superoxide dismutases in the lungs of human fetuses and newborn infants: developmental profile and alterations in hyaline membrane disease and bronchopulmonary dysplasia. (8236811)
1993

Variations for Bronchopulmonary Dysplasia

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Expression for genes affiliated with Bronchopulmonary Dysplasia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bronchopulmonary Dysplasia

Search GEO for disease gene expression data for Bronchopulmonary Dysplasia.

Pathways for genes affiliated with Bronchopulmonary Dysplasia

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Sources:
51PathCards, 61Thomson Reuters, 13EMD Millipore, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SELL, ELANE
29.6SCGB1A1, ELANE
39.3ELANE, ITGAM
49.3IL8, ITGAM
58.8IL8, ITGAM, ELANE

Compounds for genes affiliated with Bronchopulmonary Dysplasia

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1ozone469.7SCGB1A1, RNASE3, SFTPB
2curosurf469.5SFTPB, IL8, ELANE
3survanta469.5IL8, ELANE, SFTPB
4filgrastim46 1210.2ITGAM, ELANE, IL1RN
5phorbol469.1ITGAM, RNASE3, RBP4, SELL
6zymosan469.1ELANE, ITGAM, IL1RN, RNASE3
7cuprophan469.1IL1RN, ITGAM, ELANE, SELL
8polysulfone469.0IL1RN, ITGAM, ELANE, SELL
9montelukast46 52 30 1212.0RNASE3, IL8, ITGAM
10vitamin a46 25 1211.0RBP4, IL1RN, ELANE, SCGB1A1, SFTPB
11latex468.9ITGAM, RBP4, IL1RN, RNASE3, SCGB1A1
12aebsf468.9ELANE, PLA2G7, IL8
13atorvastatin46 52 30 25 1212.8SELL, ITGAM, IL1RN, PLA2G7
14rolipram46 62 3010.8ITGAM, SELL, ELANE, IL8
15hyaluronic acid46 259.8RNASE3, IL1RN, ELANE, SCGB1A1, IL8
16rantes468.7RNASE3, ITGAM, IL1RN, IL8, SELL
17epinephrine46 25 1210.7ITGAM, SELL, RNASE3, ELANE, IL1RN
18n-formylmethionyl-leucylphenylalanine468.6SELL, RNASE3, ELANE, ITGAM, IL8
19histamine46 30 2510.6RNASE3, SELL, IL1RN, ITGAM, IL8
20pentoxifylline46 129.6SELL, ELANE, ITGAM, IL1RN, IL8
21aprotinin46 129.5ELANE, IL8, PTHLH, SELL
22p002468.5ITGAM, RBP4, PLA2G7, IL1RN, RNASE3, SCGB1A1
23phospholipid468.5RBP4, PLA2G7, SCGB1A1, SFTPB, PTHLH
24prednisolone46 30 1210.4ITGAM, IL1RN, PTHLH, RNASE3, SELL
25fibrinogen468.3PLA2G7, IL1RN, ITGAM, ELANE, RNASE3, SFTPB
26aspirin46 52 30 2511.3IL1RN, PLA2G7, ITGAM, ELANE, RNASE3, SELL
27fmlp468.3IL8, SELL, RNASE3, ELANE, ITGAM, IL1RN
28hydrocortisone46 3 62 1211.3ELANE, IL1RN, PTHLH, IL8
29progesterone46 30 62 25 1212.2PLA2G7, SCGB1A1, IL1RN, PTHLH, SFTPB, RBP4
30h2o2468.1ELANE, IL8, IL1RN, RNASE3, SELL, ITGAM
31superoxide46 259.0SELL, IL8, PLA2G7, ITGAM, IL1RN, ELANE
32simvastatin46 52 62 30 25 1213.0PTHLH, RBP4, IL1RN, ITGAM, SELL, IL8
33adenylate467.9RBP4, ITGAM, ELANE, RNASE3, PTHLH, IL1RN
34cyclosporin a46 30 629.9ITGAM, RNASE3, IL1RN, ELANE, IL8
35leukotriene b446 62 259.8RNASE3, ELANE, ITGAM, IL1RN, IL8, SELL
36creatinine467.8IL1RN, ITGAM, RNASE3, SELL, PTHLH, SCGB1A1
37estrogen467.7SCGB1A1, RBP4, PLA2G7, ELANE, RNASE3, PTHLH
38cycloheximide467.5IL8, PLA2G7, IL1RN, ITGAM, SFTPB, PTHLH
39lipid467.4IL1RN, PLA2G7, PTHLH, SCGB1A1, SFTPB, ITGAM
40vegf467.3RNASE3, SELL, PTHLH, SFTPB, IL8, FGF10
41nitric oxide46 25 129.2PTHLH, SFTPB, SCGB1A1, RNASE3, ITGAM, PLA2G7
42lactate467.2IL8, SELL, PTHLH, RBP4, RNASE3, ELANE
43calcium46 52 25 1210.1SFTPB, RBP4, IL1RN, PTHLH, RNASE3, ITGAM
44heparin46 30 25 1210.0FGF10, IL8, IL1RN, ELANE, RNASE3, SELL
45retinoic acid46 258.0IL1RN, FGF10, ELANE, RBP4, ITGAM, SFTPB
46dexamethasone46 52 30 1210.0ITGAM, PLA2G7, IL8, IL1RN, RNASE3, SELL
47pge2466.7ITGAM, PLA2G7, IL8, IL1RN, ELANE, RNASE3
48serine466.7ELANE, PTHLH, SFTPB, IL8, RBP4, ITGAM
49endotoxin466.6PLA2G7, SCGB1A1, SELL, RNASE3, ELANE, ITGAM
50oxygen46 257.4IL8, PTHLH, SCGB1A1, SELL, ELANE, ITGAM

GO Terms for genes affiliated with Bronchopulmonary Dysplasia

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17Gene Ontology
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Cellular components related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.2PTHLH, RNASE3, ELANE, IL8, PLA2G7, RBP4
2extracellular spaceGO:0056157.2SFTPB, SCGB1A1, PTHLH, IL1RN, IL8, RBP4

Biological processes related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female genitalia morphogenesisGO:0488079.9FGF10, RBP4
2neutrophil chemotaxisGO:0305939.3IL8, ITGAM
3induction of positive chemotaxisGO:0509309.2FGF10, IL8
4response to lipopolysaccharideGO:0324968.9FGF10, IL1RN, ELANE, SCGB1A1
5female pregnancyGO:0075658.9SCGB1A1, PTHLH, IL1RN
6leukocyte migrationGO:0509008.9ITGAM, ELANE, SELL

Molecular functions related to Bronchopulmonary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082018.6FGF10, ITGAM, ELANE, SELL

Products for genes affiliated with Bronchopulmonary Dysplasia

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  • Antibodies
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  • Antibodies

Sources for Bronchopulmonary Dysplasia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet