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BPD
MCID: BRN056

Bronchopulmonary Dysplasia malady
89 genes, 9 tissues, 946 related diseases, 25 phenotypes, 87 articles, clinical trials.

Summaries for Bronchopulmonary Dysplasia

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44Wikipedia, 22MalaCards
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Wikipedia: Bronchopulmonary dysplasia (BPD; formerly Chronic Lung Disease of Infancy) is a chronic lung disorder...44 more...

MalaCards: Bronchopulmonary Dysplasia, also known as BPD, is related to funisitis and retinol binding protein. An important gene associated with Bronchopulmonary Dysplasia is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Glioma Invasiveness. The compounds cyclophosphamide and nicotine have been mentioned in the context of this disorder. Affiliated tissues include lung, monocytes and t cells, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Descriptions for Bronchopulmonary Dysplasia

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30NIH Rare Diseases, 8DISEASES, 32Novoseek , 43UMLS
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bronchopulmonary dysplasia 30 8 32 43
bpd 30

Related Diseases for Bronchopulmonary Dysplasia

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13GeneCards, 14GeneDecks
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Diseases related to bronchopulmonary dysplasia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 943)
idRelated DiseaseScoreTop Affiliating Genes
1funisitis28.8IL10, IL1B, IL6, IL8, ANGPT1, COL18A1
2retinol binding protein28.0RBP4, RBP2, LCN2, B2M, CCL2, TNF
3chorioamnionitis24.2MPO, MMP1, MMP9, FLT1, FGF7, IL10
4blindness20.4RBP4, SERPINE1, VEGFA, LCN2, MTHFR, B2M
5anemia18.7SELL, VEGFA, LCN2, MTHFR, B2M, MPO
6fibrosis14.2SFTPA1, SFTPA2, SFTPB, SFTPC, SFTPD, RBP4
7large cell carcinoma13.9SFTPB, SFTPC, SFTPD, GRP, PTHLH
8extrinsic allergic alveolitis13.8SFTPD, IL18, IL8, CCL3
9adenosquamous carcinoma13.8SFTPC, SFTPD, GRP, PTHLH
10lipodermatosclerosis13.8FLT1, ANGPT2, ANGPT1
11respiratory failure13.8SFTPB, SFTPD, SCGB1A1, CAT, RNASE3, ELANE
12newborn respiratory distress syndrome13.8SFTPA1, SFTPB, SERPINH1
13aceruloplasminemia13.8SOD1, SOD2, CP
14stachybotrys chartarum13.7IL18, IL1B, CCL7, CCL3
15epidural abscess13.7ITGAM, IL1RN, RNASE3
16cystic fibrosis lung disease13.7MPO, IL8, ELANE
17gingival overgrowth13.7MMP1, FN1, FGF7
18aseptic meningitis13.7CCL3, SOD2, ADA
19secondary syphilis13.7B2M, CCL3, PTHLH, CTSK, LTA
20bacterial meningitis13.7IL1B, IL8, CCL3, SOD2, ADA
21alcoholic liver cirrhosis13.6IL8, CAT, SOD1, SOD2
22bronchitis13.6SELL, HMGB1, TXN, CP, EPO
23chronic rhinitis13.6MPO, RNASE3, EDN1, EPX
24leukocyte-adhesion deficiency syndrome13.6SELL, ITGAM, ITGB2, IL1B, ICAM1
25bone cancer13.6IL1B, IL1RAPL2, IL1RN, PTHLH, CTSK
26diffuse idiopathic skeletal hyperostosis13.6RBP4, IGFBP3, IGF1
27chronic infantile neurological cutaneous articular syndrome13.6IL18, IL1B, IL1RAPL2, IL1RN
28chronic sphenoidal sinusitis13.6IL4, IL8, RNASE3, ELANE
29osteoporosis, postmenopausal13.6IL1RAPL2, IL1RN, IGF1, PTHLH, CTSK
30cinca syndrome13.5IL18, IL1B, IL1RAPL2
31hemosiderosis13.5MIF, CAT, CP, EPO
32food allergy13.5IL4, TXN, RNASE3, EPX
33calciphylaxis13.5FN1, PTHLH, EPO
34henoch-schoenlein purpura13.5MPO, ICAM1, RNASE3
35congenital hemolytic anemia13.5HBG2, ADA, EPO
36osteopenia/osteoporosis13.5IGFBP3, IGF1, PTHLH, CTSK
37muckle-wells syndrome13.5IL1B, IL1RAPL2, IL8
38intracranial thrombosis13.5MTHFR, F3, PLA2G7
39interstitial nephritis13.5RBP4, B2M, ACE, STK16
40male infertility13.5MTHFR, MIF, CAT, TXN, SOD1
41mast-cell leukemia13.5MPO, CCL2, CCL3
42tongue cancer13.5MMP2, MMP9, FLT1, TNC
43pulmonary eosinophilia13.5SFTPD, IL4, IL8, CCL7, CCL3, RNASE3
44chronic granulomatous disease13.5MPO, CAT, HBG2, SOD1, ADA
45intrinsic asthma13.5IL4, CCL7, RNASE3
46spermatic cord torsion13.4GPX1, CAT, SOD2
47ulceration of vulva13.4MMP1, FN1, FGF7, ANGPT2, ANGPT1, RNASE3
48exfoliation syndrome13.4MPO, GSTP1, CAT, SOD1
49allergic conjunctivitis13.4IL4, IL8, ICAM1, RNASE3, SOD1
50erdheim-chester disease13.4IL1B, CCL2, IGF1

Graphical network of the top 20 diseases related to bronchopulmonary dysplasia:



Graphical network of diseases related to bronchopulmonary dysplasia

Clinical Features for Bronchopulmonary Dysplasia

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Drugs & Therapeutics for Bronchopulmonary Dysplasia

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for bronchopulmonary dysplasia

Drug clinical trials:

Search ClinicalTrials for bronchopulmonary dysplasia

Search NIH Clinical Center for bronchopulmonary dysplasia

Search CenterWatch for bronchopulmonary dysplasia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-Cell-Based therapeutic approaches for bronchopulmonary dysplasia:
PNEUMOSTEM®, umbilical cord blood derived mesenchymal stem cell for treating Bronchopulmonary Dysplasia

Genetic Tests for Bronchopulmonary Dysplasia

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Anatomical Context for Bronchopulmonary Dysplasia

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21LifeMap Discovery™, 22MalaCards
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MalaCards organs/tissues related to bronchopulmonary dysplasia:

22
Lung, Monocytes, T cells, B cells, Endothelial, Fetal lung

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Embryonic and adult cells/anatomical compartments related to bronchopulmonary dysplasia:
id Organ / Tissue -> Anatomical Compartment -> Cell Relevance
1 Lung -> Alveoli -> Alveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 Lung -> Alveoli -> Alveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 Lung -> Pulmonary Capillary Plexus  Potential therapeutic candidate, affected by disease

Phenotypes for genes affiliated with Bronchopulmonary Dysplasia

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25MGI
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MGI Mouse Phenotypes related to bronchopulmonary dysplasia:

25 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:000537910.4SELL, LTA, CTSK, FGF10, RARG
2renal/urinary system phenotypeMP:000536710.3SOD2, SCGB1A1, MMP14, COL18A1, FGF10, PTHLH
3respiratory system phenotypeMP:000538810.3SFTPC, SFTPD, SELL, SERPINB1, SCGB1A1, NOS1
4hematopoietic system phenotypeMP:00053979.8SOD2, ADA, EPO, EPX, TAP1, CTSK
5craniofacial phenotypeMP:00053829.8CTSK, EDN1, FGF10, MMP16, RARG
6integument phenotypeMP:00107719.4F3, RARG, ITGB2, GSTP1, FGF10, FGF7
7liver/biliary system phenotypeMP:00053709.1ADA, EPO, SOD1, IL6, VEGFA
8other phenotypeMP:00053959.0FN1, SOD2, RBP2, SERPINH1, RARG, NOS2
9immune system phenotypeMP:00053878.8LCN2, PTHLH, CTSK, NOS1, ELANE, SOD2
10limbs/digits/tail phenotypeMP:00053718.2LTA, FN1, CTSK, PTHLH, IL10, FGF10
11nervous system phenotypeMP:00036318.2TGFB1, FGF10, FLT1, MMP2, EDN1, LTA
12growth/size phenotypeMP:00053787.7IL18, IL6, ANGPT1, GPX1, F3, ESAM
13skeleton phenotypeMP:00053907.4MMP14, MMP2, FN1, FGF10, IGF1, PTHLH
14behavior/neurological phenotypeMP:00053867.2TNC, PTHLH, NOS1, NOS2, ACE, SOD2
15digestive/alimentary phenotypeMP:00053817.1PLAU, MMP16, MMP14, B2M, RARG, VEGFA
16adipose tissue phenotypeMP:00053756.8IL6, CCL2, IGFBP3, IGF1, TNF, PTHLH
17normal phenotypeMP:00028736.6ELANE, RBP4, SOD3, ADA, EPO, TNC
18reproductive system phenotypeMP:00053896.0SOD2, IL6, TIMP1, B2M, RARG, TGFB1
19mortality/agingMP:00107685.3MTHFR, ITGB2, MMP14, MMP16, FLT1, FGF10
20tumorigenesisMP:00020065.3SFTPC, SELL, SERPINE1, SCGB1A1, B2M, MMP2
21muscle phenotypeMP:00053694.4IL18, RBP4, DAG1, PLAU, NOS1, NOS2
22vision/eye phenotypeMP:00053914.1F3, SOD2, CP, SOD1, TGFB1, LTA
23homeostasis/metabolism phenotypeMP:00053763.6ADA, EPO, SFTPB, SFTPD, RBP4, RBP2
24cellular phenotypeMP:00053843.0RBP4, SELL, SERPINB1, VEGFA, LCN2, B2M
25cardiovascular system phenotypeMP:00053853.0EPO, PLAU, MMP9, FN1, FLT1, FGF10

Publications for genes affiliated with Bronchopulmonary Dysplasia

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35PubMed
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Articles related to bronchopulmonary dysplasia:

(show top 50)    (show all 87)
idTitleAuthorsYearAffiliating Genes
1Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia. (21836138)Hadchouel A.... Delacourt C.2011SPOCK2
2Adenosine deaminase levels in premature infants with respiratory distress syndrome and bronchopulmonary dysplasia. (20836741)Canpolat F.E.... Tekinalp G.2011ADA
3Urinary I^-2-microglobulin as an alternative marker fo r fetal inflammatory response and development of bronchopulmonary dysplasia in premature infants. (21127468)Shima Y.... Migita M.2011B2M
4A Polymorphism in the Macrophage Migration Inhibitory Factor Promoter is Associated With Bronchopulmonary Dysplasia. (21045753)Prencipe G.... De Benedetti F.2010MIF
5The role of plasminogen activator inhibitor-1 and ang iotensin-converting enzyme gene polymorphisms in bronchopulmonary dysplasia. (20818980)Ince D.A.... Ozbek N.2010SERPINE1, ACE
6High-mobility group box-1 protein in tracheal aspirat es from premature infants: relationship with bronchopulmonary dysplasia and ste roid therapy. (20182437)Aghai Z.H.... Bhandari V.2010HMBOX1
7Polymorphisms of interleukin 18 in the genetics of pr eterm birth and bronchopulmonary dysplasia. (20971720)Krueger M.... GAPpel W.2010IL18
8Anti-inflammatory effects of erythropoietin on hyper oxia-induced bronchopulmonary dysplasia in newborn rats (19951473)Wang X.L.... Xue X.D.2009MPO, CCL2, EPO
9Epithelial lining fluid neutrophil-gelatinase-associated lipocalin levels in premature newborns with bronchopulmonary dysplasia and patency of ductus arteriosus. (18336743)Capoluongo E.... Ameglio F.2008LCN2
10Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. (18784838)Hadchouel A.... Delacourt C.2008MMP2, MMP14, MMP16
11Angiopoietin 2 concentrations in infants developing bronchopulmonary dysplasia: attenuation by dexamethasone. (18033304)Aghai Z.H.... Bhandari V.2008ANGPT2
12Genetic risk factors of bronchopulmonary dysplasia. (18614962)Przemko K.... Jacek P.J.2008TGFB1, IGF1, VEGFA
13Insulin-like growth factor-I and complications of prematurity: a focus on bronchopulmonary dysplasia. (18605947)Capoluongo E.... Zuppi C.2008IGF1
14Lower erythrocyte glutathione peroxidase activity in bronchopulmonary dysplasia in the first week of neonatal life. (18063869)Fu R.H.... Yang P.H.2008GPX1
15Cord blood Clara cell protein CC16 predicts the development of bronchopulmonary dysplasia. (18521627)Schrama A.J.... Walther F.J.2008SCGB1A1
16FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. (17071719)Benjamin J.T.... Prince L.S.2007FGF10
17Genetic analysis of the dystroglycan gene in bronchopulmonary dysplasia affected premature newborns. (17196572)Concolino P.... Sciandra F.2007DAG1
18Constitutive IL-10 expression by lung inflammatory cells and risk for bronchopulmonary dysplasia. (17237722)Garingo A.... Minoo P.2007IL10
19Single nucleotide polymorphisms of tumor necrosis factor-alpha and the susceptibility to bronchopulmonary dysplasia. (17123322)Strassberg S.S.... Parton L.A.2007TNF
20Lower parathyroid hormone-related protein content of tracheal aspirates in very low birth weight infants who develop bronchopulmonary dysplasia. (16864707)Rehan V.K.... Torday J.S.2006PTHLH
21Pathogenesis of bronchopulmonary dysplasia: the role of interleukin 1beta in the regulation of inflammation-mediated pulmonary retinoic acid pathways in transgenic mice. (16813970)Bry K.... Lappalainen U.2006RARG, IL1B, CRABP1
22No association between TAP1 DpnII polymorphism and bronchopulmonary dysplasia. (16640035)Lin H.C.... Tsai C.H.2005TAP1
23Erythrocyte Cu/Zn superoxide dismutase activity in preterm infants with and without bronchopulmonary dysplasia. (15767740)Fu R.H.... Chou Y.H.2005SOD1
24Deletion allele of angiotensin-converting enzyme is associated with increased risk and severity of bronchopulmonary dysplasia. (16356438)Kazzi S.N.... Quasney M.W.2005ACE
25Interleukin-10 -1082 G/A polymorphism and risk of death or bronchopulmonary dysplasia in ventilated very low birth weight infants. (15678510)Yanamandra K.... Baier R.J.2005IL10
26Polymorphism of tumor necrosis factor-alpha and risk and severity of bronchopulmonary dysplasia among very low birth weight infants. (15286263)Kazzi S.N.... Buhimschi I.2004TNF, LTA
27CC chemokine concentrations increase in respiratory distress syndrome and correlate with development of bronchopulmonary dysplasia. (14730659)Baier R.J.... Kruger T.E.2004CCL8, CCL7
28The Angiotensin Converting Enzyme Insertion/Deletion polymorphism is not associated with an increased risk of death or bronchopulmonary dysplasia in ventilated very low birth weight infants. (15610555)Yanamandra K.... Baier R.J.2004ACE
29Data mining and multiparameter analysis of lung surfactant protein genes in bronchopulmonary dysplasia. (15102713)Rova M.... Hallman M.2004SFTPD, SFTPA1, SFTPB
30Role of antioxidant nutrients and lipid peroxidation in premature infants with respiratory distress syndrome and bronchopulmonary dysplasia. (12660915)Falciglia H.S.... Falciglia G.A.2003SOD1
31Pulmonary trypsin-2 in the development of bronchopulmonary dysplasia in preterm infants. (12949286)Cederqvist K.... Andersson S.2003PRSS2
32Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia. (14633629)Gauldie J.... Warburton D.2003STK16
33Gelatinase activities in the airways of premature infants and development of bronchopulmonary dysplasia. (12376362)Danan C.... Delacourt C.2002MMP2, MMP9, TIMP1
34Serial changes in levels of IL-6 and IL-1beta in premature infants at risk for bronchopulmonary dysplasia. (11276135)Kazzi S.N.... Janisse J.2001IL6, IL1B
35Localization and potential role of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 and -2 in different phases of bronchopulmonary dysplasia. (11726737)Dik W.A.... Versnel M.A.2001MMP1
36Vitamin A status and postnatal dexamethasone treatmen t in bronchopulmonary dysplasia. (10969101)Shenai J.P.... Chytil F.2000RBP4
37Effects of early inhaled beclomethasone therapy on tracheal aspirate inflammatory mediators IL-8 and IL-1ra in ventilated preterm infants at risk for bronchopulmonary dysplasia. (11015126)Gupta G.K.... Frantz I.D.2000IL8, IL1RN
38Hyperoxia induces thioredoxin and thioredoxin reductase gene expression in lungs of premature baboons with respiratory distress and bronchopulmonary dysplasia. (10424622)Das K.C.... White C.W.1999TXN
39Effect of oxygen on lung superoxide dismutase activities in premature baboons with bronchopulmonary dysplasia. (9887057)Morton R.L.... White C.W.1999SOD1, SOD2
40L-selectin expression on polymorphonuclear leukocytes and monocytes in premature infants: reduced expression after dexamethasone treatment for bronchopulmonary dysplasia. (9470000)Waisman D.... Bondy G.P.1998SELL
41Fibronectin expression in bronchopulmonary dysplasia. (9724336)Sinkin R.A.... Metlay L.A.1998FN1
42Eosinophil cationic protein in tracheal aspirates of preterm infants with bronchopulmonary dysplasia. (9202617)Raghavender B.... Smith J.B.1997RNASE3
43Cromolyn sodium prophylaxis inhibits pulmonary proinflammatory cytokines in infants at high risk for bronchopulmonary dysplasia. (9372670)Viscardi R.M.... Palmer T.W.1997IL1B, IL1RN
44Airway lesions and superoxide dismutase (SOD) distribution in bronchopulmonary dysplasia (BPD). (9642974)Ohbayashi C.... Itoh H.1997SOD1
45Altered platelet-activating factor levels and acetylhydrolase activities are associated with increasing severity of bronchopulmonary dysplasia. (8853062)Gaylord M.S.... Snyder F.1996PLA2G7
46Potential role of interleukin-1 in the development of bronchopulmonary dysplasia. (8727076)Rindfleisch M.S.... Viscardi R.M.1996IL1B, IL1RN, IL1RAPL2
47Use of the intramuscular relative-dose-response test to predict bronchopulmonary dysplasia in premature infants. (8604659)Zachman R.D.... Pi J.T.1996RBP4
48Secretory leukocyte protease inhibitor and lung inflammation in developing bronchopulmonary dysplasia. (7913723)Watterberg K.L.... Murphy S.1994ELANE, SERPINB1
49Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates. (8165067)Groneck P.... Speer C.P.1994IL8, ELANE
50Lipid peroxidation and expression of copper-zinc and manganese superoxide dismutase in lungs of premature infants with hyaline membrane disease and bronchopulmonary dysplasia. (2230537)Strange R.C.... Hume R.1990SOD2

Expression for genes affiliated with Bronchopulmonary Dysplasia

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Bronchopulmonary Dysplasia

Pathways for genes affiliated with Bronchopulmonary Dysplasia

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36QIAGEN, 38Reactome, 41Thomson Reuters, 10EMD Millipore, 20KEGG
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Pathways related to bronchopulmonary dysplasia according to GeneDecks:

(show top 50)    (show all 111)
idPathwayScoreTop Affiliating Genes
1RAR-Gamma-RXR-Alpha Degradation3610.5RARG, ANGPT1, CCL8, LTA, CCL3, CCL7
2Glioma Invasiveness3610.3TIMP1, ITGB2, FGF7, FGF10, ITGAM, PLAU
3PTEN Pathway3610.1ITGAM, FN1, ITGB2, FGF10, COL18A1, SPOCK2
4PGC1Alpha Pathway369.8IL1B, CCL3, CCL7, IL8, CCL8, IL4
5Activation of Matrix Metalloproteinases389.8ELANE, TIMP1, PRSS2, MMP1, MMP16, MMP2
6NFAT Signaling and Lymphocyte Interactions369.7CCL7, ANGPT1, IL4, ANGPT2, CCL8, CCL2
7ILK Signaling369.7ITGAM, COL18A1, ITGB2, TIMP1, SPOCK2, TNC
8Regulation of eIF4 and p70S6K369.5CCL3, CCL7, CCL8, IL6, IL4, IL18
9LDL Oxidation in Atherogenesis369.4ICAM1, CCL3, CCL2, IL1B, MPO, TNF
10JNK Pathway369.3TGFB1, CCL3, FLT1, FGF7, IL6, ANGPT2
11Molecular Mechanisms of Cancer369.3TIMP1, LTA, COL18A1, SPOCK2, CCL7, CCL8
12IL-6 Pathway369.2CCL3, ANGPT2, TIMP1, CCL2, CCL7, CCL8
13Cell adhesion_ECM remodeling419.1MMP16, SERPINE1, MMP1, MMP14, TIMP1, PLAU
14Cell adhesion ECM remodeling109.1TIMP1, PLAU, IGF1, SERPINE1, MMP1, MMP14
15UPA-UPAR Pathway369.0PLAU, ITGB2, MMP1, MMP2, FN1, TNC
16Amoebiasis209.0ITGAM, ITGB2, FN1, IL8, SERPINB1, IL1B
17PPAR Pathway369.0LTA, ITGB2, FGF10, TNF, ITGAM, IL6
18Transendothelial Migration of Leukocytes369.0CCL2, CCL8, IL8, FN1, MMP9, MMP2
19Phospholipase-C Pathway368.9FGF10, TGFB1, TNC, PLA2G7, FGF7, IL6
20Immune response MIF-mediated glucocorticoid regulation108.8IL8, MIF, MMP1, IL6, ICAM1, TNF
21Immune response_MIF-mediated glucocorticoid regulation418.8ICAM1, IL8, IL6, MIF, MMP1, NOS2
22SOCS Pathway368.7IL10, CCL3, CCL2, CCL8, ANGPT1, ANGPT2
23Pertussis208.7IL8, TNF, ITGB2, ITGAM, SFTPA1, IL10
24Endothelin-1 Signaling Pathway368.6IL10, IL18, IL1B, IL4, IL6, ANGPT1
25Cytokine Network368.5IL4, IL10, IL6, IL18, IL8, IL1B
26Immune response IL-1 signaling pathway108.5HMOX1, IL8, TNF, NOS2, EDN1, F3
27Immune response_IL-1 signaling pathway418.5NOS2, TNF, F3, IL8, SERPINE1, IL6
28Malaria208.4IL8, ICAM1, ITGB2, IL10, IL18, IL1B
29MAPK Signaling368.4TNC, SPOCK2, TNF, COL18A1, FGF7, IGF1
30Akt Signaling368.2ITGAM, CCL2, CCL3, TNF, CCL7, CCL8
31Glucocorticoid Receptor Signaling368.2CCL3, CCL2, CCL7, CCL8, IL10, IL18
32all-trans-Retinoic Acid Signaling in Brain368.1RARG, IL10, IL18, IL1B, IL4, IL8
33MIF Regulation of Innate Immune Cells368.1LTA, TNF, CCL3, CCL2, CCL7, CCL8
34MIF Mediated Glucocorticoid Regulation368.1IL6, IL4, IL1B, IL18, IL10, MIF
35STAT3 Pathway368.1IL10, IL18, CCL2, IL4, IL6, IL8
36PEDF Induced Signaling368.1SOD2, LTA, TNF, CCL3, CCL2, CCL7
37TGF-Beta Pathway368.0TGFB1, TIMP1, IGF1, CCL3, CCL2, CCL7
38ERK Signaling368.0ANGPT1, CCL8, CCL7, CCL3, TNC, SPOCK2
39JAK-STAT Pathway367.9IL6, EPO, IL4, IL1B, IL18, IL10
40Pathways in cancer207.8FGF10, FGF7, TGFB1, GSTP1, MMP9, MMP1
41Rho Family GTPases367.8TGFB1, TIMP1, LTA, COL18A1, SPOCK2, TNC
42Chagas disease (American trypanosomiasis)207.7CCL2, ACE, IL8, TGFB1, NOS2, TNF
43Rheumatoid arthritis207.5IL18, FLT1, MMP1, ITGB2, VEGFA, IL1B
44PAK Pathway367.4LTA, FLT1, TNF, IGF1, CCL3, CCL2
45MAPK Family Pathway367.4ANGPT2, ANGPT1, CCL8, CCL7, CCL2, CCL3
46Leishmaniasis207.4NOS2, ITGAM, IL10, IL1B, IL4, TGFB1
47Tec Kinases Signaling367.4ANGPT1, ITGAM, ITGB2, FGF10, ANGPT2, IL8
48p38 Signaling367.4TNF, TIMP1, IL18, TGFB1, IGF1, CCL3
49Antioxidant Action of Vitamin-C367.4CCL8, TGFB1, CCL7, CCL2, CCL3, IGF1
50Cytokine-cytokine receptor interaction206.8IL6, IL8, CCL8, CCL7, CCL2, CCL3

Compounds for genes affiliated with Bronchopulmonary Dysplasia

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Sources:
32Novoseek , 34PharmGKB, 9DrugBank, 42Tocris Bioscience, 18HMDB
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Compounds related to bronchopulmonary dysplasia according to GeneDecks:

(show top 50)    (show all 481)
idCompoundScoreTop Affiliating Genes
1cyclophosphamide32 34 9 9 13.8ITGB2
2nicotine32 34 9 9 13.6SELL, GRP, PTHLH
3progesterone32 42 9 18 9 14.3SFTPB, RBP4, SCGB1A1, MMP14, FLT1, CCL8
4vitamin a32 9 18 9 12.8SFTPB, RBP4, RBP2, RARG, SCGB1A1, LCN2
5hyaluronic acid32 18 10.7SCGB1A1, B2M, ITGB2, MMP1, FN1, FGF7
6polysulfone32 9.5SELL, B2M, ITGAM, ITGB2, IL1B, IL1RAPL2
7n acetylcysteine32 9.5ITGAM, MMP1, MMP2, MMP9, IL18, PLAU
8bleomycin32 9 9 11.4SFTPB, SFTPC, GSTP1, FGF7, IL4, CCL2
9ascorbic acid32 18 10.3SFTPB, RBP4, SERPINH1, ITGAM, MMP2, GSTP1
10doxycycline32 9 9 11.1SFTPB, SFTPC, SCGB1A1, MMP1, MMP2, MMP9
11peroxynitrite32 9.0SFTPB, SFTPC, MPO, CCL3, GPX1, CAT
12doxorubicin32 34 9 9 11.6B2M, MMP1, FN1, FLT1, MIF, GSTP1
13epinephrine32 9 18 9 11.6SELL, ITGAM, MMP1, MMP2, MMP9, GRP
14cytochalasin d32 42 9.3SELL, ITGB2, MMP1, MMP14, MMP2, MMP9
15glutamine32 8.2SFTPD, B2M, ITGAM, FN1, FGF7, GRP
16oxygen32 18 9.1SFTPB, SFTPC, SFTPD, RBP4, SCGB1A1, MPO
17testosterone32 9 18 9 11.1MTHFR, B2M, MMP1, MMP2, MMP9, GSTP1
18histamine32 18 8.9SFTPD, SELL, MPO, ITGAM, ITGB2, FGF7
19matrigel32 7.8SERPINE1, VEGFA, MMP1, MMP14, MMP2, MMP9
20cysteine32 7.8SFTPB, SFTPC, SFTPD, RBP4, MTHFR, ITGAM
21cholesterol32 9 18 9 10.6SFTPB, SFTPC, SFTPD, RBP4, SERPINE1, MTHFR
22ribonucleic acid32 7.6SFTPB, SFTPC, RBP4, MMP1, MMP14, MMP2
23rantes32 7.5SELL, ITGAM, ITGB2, MMP1, MMP9, MIF
24polymyxin b32 7.5SERPINE1, ITGB2, IL10, IL1B, IL1RN, IL4
25prednisolone32 9 9 9.5SFTPD, SELL, LCN2, MPO, ITGAM, ITGB2
26vitamin d32 7.4SERPINE1, MTHFR, B2M, ITGAM, ITGB2, FN1
27diphenyleneiodonium32 7.4VEGFA, MPO, IL1B, IL8, CCL2, ICAM1
28norepinephrine32 9 18 9 10.4SELL, MMP1, MMP2, MMP9, MIF, GRP
29neopterin32 7.3LCN2, B2M, IL10, IL18, IL1B, IL1RAPL2
30adenylate32 7.3RBP4, SERPINE1, ITGAM, ITGB2, MMP9, GSTP1
31il 1032 7.3IL10, IL18, IL1B, IL1RAPL2, IL1RN, IL4
32hydrocortisone32 9 9 9.3MMP1, MMP2, FLT1, MIF, FGF7, GRP
33sb 20358032 42 8.2VEGFA, ITGAM, ITGB2, MMP1, MMP2, MMP9
34tgf beta132 7.2SERPINE1, MMP1, MMP14, MMP2, FN1, FLT1
35cisplatin32 34 9 9 10.2VEGFA, MTHFR, B2M, MPO, FN1, FLT1
36aspirin32 34 18 9.1SELL, SERPINE1, MTHFR, ITGAM, MMP1, MMP2
37pd 98,05932 6.9SERPINE1, ITGAM, MMP1, MMP14, MMP2, MMP9
38rosiglitazone32 9 18 9 9.8RBP4, SERPINE1, LCN2, MMP1, MMP2, MMP9
39paraffin32 6.7SFTPB, SELL, VEGFA, B2M, MPO, MMP14
40infliximab32 9 9 8.7VEGFA, MMP1, IL10, IL18, IL1B, IL1RAPL2
41herbimycin a32 42 7.6SELL, ITGB2, MMP1, MMP14, MMP2, MMP9
42methotrexate32 34 42 9 9 10.2SERPINE1, MTHFR, MMP1, MMP2, MMP9, GSTP1
43tyrosine32 5.7SFTPB, SELL, SERPINH1, VEGFA, LCN2, ITGAM
44vegf32 5.6SFTPB, SFTPC, SERPINH1, SERPINE1, MPO, ITGAM
45ly29400232 5.5VEGFA, ITGAM, ITGB2, MMP14, MMP2, MMP9
46nitric oxide32 9 18 9 8.1SFTPB, SFTPD, SERPINH1, SERPINE1, SCGB1A1, LCN2
47lactate32 5.1SFTPD, RBP4, SELL, B2M, MPO, ITGAM
48serine32 4.6SFTPB, SFTPD, RBP4, SELL, SERPINH1, SERPINE1
49actinomycin d32 4.3SFTPB, SFTPC, SERPINE1, VEGFA, MMP14, MMP9
50dexamethasone32 42 34 9 9 7.1SFTPB, SFTPC, SFTPD, RBP4, SELL, SERPINE1

GO Terms for genes affiliated with Bronchopulmonary Dysplasia

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12Gene Ontology
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Cellular components related to bronchopulmonary dysplasia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.6TNC, SERPINE1, MMP14, FN1, FGF10, F3
2platelet alpha granule lumenGO:0310938.7SERPINE1, TIMP1, IGF1, FN1, VEGFA, TGFB1
3external side of plasma membraneGO:0098978.5ICAM1, IL4, SELL, TNF, ACE, ADA
4proteinaceous extracellular matrixGO:0055788.0MMP2, MMP9, FN1, SPOCK2, TGFB1, MMP16
5cell surfaceGO:0099867.7TNF, FGF10, TGFB1, VEGFA, MMP16, MIF
6extracellular regionGO:0055764.9SFTPA1, FGF7, GRP, IL18, IL1B, IL6
7extracellular spaceGO:0056152.0SFTPB, FGF10, FGF7, GRP, IL10, IL18

Biological processes related to bronchopulmonary dysplasia according to GeneDecks:

(show top 50)    (show all 77)
idNameGO IDScoreTop Affiliating Genes
1respiratory gaseous exchangeGO:00758510.5SFTPA1, SFTPB, SFTPC, SFTPD, EDN1, SFTPA2
2monocyte chemotaxisGO:00254810.3FLT1, IL6, CCL7, CCL2, CCL3
3neutrophil chemotaxisGO:03059310.2IL8, CCL2, EDN1, ITGB2, IL1B, CCL3
4embryo implantationGO:00756610.1MMP9, SOD1, EPO, SCGB1A1, IL1B
5cellular response to tumor necrosis factorGO:07135610.1EDN1, IL18, CCL2, CCL3, ICAM1, IL8
6cellular response to interleukin-1GO:07134710.0IL8, CCL2, CCL3, ICAM1, EDN1, MMP9
7chronic inflammatory response to antigenic stimulusGO:00243910.0TNF, IL1RN, IL1B
8leukocyte migrationGO:05090010.0SELL, MMP1, FN1, ANGPT2, ITGB2, ANGPT1
9response to hyperoxiaGO:0550939.9CAT, SFTPC, MMP9, SFTPB, SERPINE1, EPO
10cellular calcium ion homeostasisGO:0068749.9CCL7, TGFB1, ELANE, CCL3, CCL8, CCL2
11collagen catabolic processGO:0305749.9MMP9, MMP2, MMP16, PRSS2, MMP1
12extracellular matrix disassemblyGO:0226179.9ELANE, TIMP1, PRSS2, MMP16, MMP1, MMP9
13response to lipopolysaccharideGO:0324969.9LTA, SFTPB, SFTPC, ELANE, FGF10, F3
14response to radiationGO:0093149.8TXN, TGFB1, IL18, MMP9, ANGPT2
15positive chemotaxisGO:0509189.7HMGB1, CCL3, ANGPT1, FGF7, FGF10, MIF
16cell-cell signalingGO:0072679.7IL18, ITGB2, CCL8, IL10, CCL3, TXN
17negative regulation of growth of symbiont in hostGO:0441309.6TNF, LTA, ELANE, IL10
18agingGO:0075689.5IL1B, F3, TIMP1, TGFB1, ADA, EPO
19protein kinase B signaling cascadeGO:0434919.5IL1B, CCL2, CCL3, TNF, TGFB1
20lipopolysaccharide-mediated signaling pathwayGO:0316639.5IL18, TGFB1, TNF, CCL3, IL1B, CCL2
21cellular response to organic cyclic compoundGO:0714079.4IL1B, IL18, CCL2, CCL3, TNF, TGFB1
22positive regulation of smooth muscle cell proliferationGO:0486619.4EDN1, TNF, HMOX1, IGF1, IL6, FLT1
23positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.4IL1B, FGF10, FLT1, VEGFA
24positive regulation of chemokine biosynthetic processGO:0450809.4TNF, HMOX1, IL4, IL1B
25cellular response to interferon-gammaGO:0713469.4CCL2, CCL3, NOS2, IL18
26response to mechanical stimulusGO:0096129.3TNF, F3, CCL2, ANGPT2, MMP9
27cellular response to lipopolysaccharideGO:0712229.3NOS2, IL10, ICAM1, CCL2, IL8, GSTP1
28female pregnancyGO:0075659.3IL1RN, TGFB1, SCGB1A1, IL4, FLT1, PTHLH
29MAPK cascadeGO:0001659.3IL18, TGFB1, TNF, CCL3, CCL2, IL1B
30signal transductionGO:0071659.3CCL8, LTA, EPO, IL1B, IL8, GRP
31regulation of cell shapeGO:0083609.3VEGFA, ITGB2, FN1, CCL2, ICAM1, CCL3
32positive regulation of protein kinase B signaling cascadeGO:0518979.3CCL3, TGFB1, GPX1, IGF1, F3, TNF
33positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2IGF1, VEGFA, MIF, FGF10, FGF7, IL6
34extracellular matrix organizationGO:0301989.1TIMP1, ELANE, COL18A1, MMP2, TNF, PRSS2
35positive regulation of angiogenesisGO:0457669.1F3, ANGPT2, IL1B, FLT1, HMOX1, SERPINE1
36response to glucocorticoid stimulusGO:0513849.0IL10, IL1B, CCL2, HMGB1, IL1RN, SFTPC
37platelet degranulationGO:0025769.0TIMP1, TGFB1, SOD1, IGF1, FN1, VEGFA
38positive regulation of cell migrationGO:0303359.0FLT1, MMP14, CCL7, VEGFA, F3, EDN1
39angiogenesisGO:0015258.9MMP2, ANGPT2, VEGFA, HMOX1, FN1, IL8
40positive regulation of MAP kinase activityGO:0434068.8VEGFA, TNF, FLT1, EDN1, ELANE, TGFB1
41negative regulation of cell proliferationGO:0082858.5RARG, COL18A1, IL1B, IL6, PTHLH, TNF
42positive regulation of peptidyl-serine phosphorylationGO:0331388.4TGFB1, ANGPT1, VEGFA, MIF, IL6, TNF
43inflammatory responseGO:0069548.4ITGB2, IL1B, IL18, IL10, IL8, CCL8
44anti-apoptosisGO:0069168.4HMOX1, ANGPT1, CCL2, GPX1, IGF1, IL10
45positive regulation of cell proliferationGO:0082848.2FLT1, VEGFA, FGF7, IL6, IGF1, TIMP1
46response to drugGO:0424937.9ICAM1, B2M, SOD1, TGFB1, EDN1, LTA
47negative regulation of apoptotic processGO:0430667.5EPO, CAT, TIMP1, SOD2, SERPINE1, ANGPT1
48blood coagulationGO:0075967.2TGFB1, SOD1, NOS1, ITGB2, ITGAM, VEGFA
49positive regulation of transcription from RNA polymerase II promoterGO:0459446.9SERPINE1, TNF, HMGB1, IGF1, IL6, IL4
50response to hypoxiaGO:0016666.8ADA, MMP9, FLT1, IL18, ANGPT2, ANGPT1

Molecular functions related to bronchopulmonary dysplasia according to GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1retinol bindingGO:01984110.4RBP4, RBP2, CRABP1
2retinal bindingGO:01691810.3RBP4, CRABP1, RBP2
3chemokine activityGO:00800910.2CCL8, CCL3, CCL2, CCL7, IL8
4bacterial cell surface bindingGO:05163510.0DAG1, SFTPD, ELANE
5chemoattractant activityGO:0420569.6HMGB1, CCL3, FGF7, FGF10, MIF, VEGFA
6protease bindingGO:0020209.6TNF, SERPINE1, F3, ELANE, SELL
7cell surface bindingGO:0434989.4ICAM1, F3, MIF, VEGFA
8heparin bindingGO:0082019.2FGF7, MPO, FN1, FGF10, CCL8, CCL7
9receptor bindingGO:0051029.2ITGB2, MIF, GRP, ANGPT2, CCL2, CAT
10heme bindingGO:0200379.1EPX, CAT, HMOX1, HBG2, NOS2, NOS1
11growth factor activityGO:0080837.7IL4, IL6, IGF1, TGFB1, FGF10, IL1B
12cytokine activityGO:0051257.3IL4, EDN1, IL6, LTA, TNF, HMGB1
13protein bindingGO:0055153.4COL18A1, NOS2, NOS1, PLAU, DAG1, DYNLRB1

Sources for Bronchopulmonary Dysplasia

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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