MCID: BRN056
MIFTS: 48

Bronchopulmonary Dysplasia

Categories: Rare diseases, Respiratory diseases, Fetal diseases

Aliases & Classifications for Bronchopulmonary Dysplasia

MalaCards integrated aliases for Bronchopulmonary Dysplasia:

Name: Bronchopulmonary Dysplasia 38 50 56 52 69
Bpd 50 56

Characteristics:

Orphanet epidemiological data:

56
bronchopulmonary dysplasia
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Infancy,Neonatal; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 56 ORPHA70589
MESH via Orphanet 43 D001997
UMLS via Orphanet 70 C0006287
ICD10 via Orphanet 34 P27.1

Summaries for Bronchopulmonary Dysplasia

NIH Rare Diseases : 50 the following summary is from orphanet, a european reference portal for information on rare diseases and orphan drugs.orpha number: 70589disease definitionbronchopulmonary dysplasia is a chronic respiratory disease that results from complications related to lung injury during the treatment of infant acute respiratory distress syndrome (see these terms) in low-birth-weight premature infants or from abnormal lung development in older infants. clinical signs are tachypnea, tachycardia and signs of respiratory distress such as intercostal recession, grunting and nasal flaring.visit the orphanet disease page for more resources. last updated: 2/29/2012

MalaCards based summary : Bronchopulmonary Dysplasia, also known as bpd, is related to asthma and borderline personality disorder. An important gene associated with Bronchopulmonary Dysplasia is SCGB1A1 (Secretoglobin Family 1A Member 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Interleukin-4 and 13 signaling. The drugs RespiGam and Procaterol have been mentioned in the context of this disorder. Affiliated tissues include Lung and Lung, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 72 Bronchopulmonary dysplasia (BPD; formerly chronic lung disease of infancy) is a chronic lung disease in... more...

Related Diseases for Bronchopulmonary Dysplasia

Diseases related to Bronchopulmonary Dysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
id Related Disease Score Top Affiliating Genes
1 asthma 27.6 CXCL8 ELANE ITGAM RNASE3 SCGB1A1 SELL
2 borderline personality disorder 11.4
3 pulmonary hypertension, neonatal 10.9
4 bronchial disease 10.9
5 congenital diaphragmatic hernia 10.7 CXCL8 SELL
6 lymphangiectasia, intestinal 10.6 CXCL8 ELANE
7 paroxysmal cold hemoglobinuria 10.6 SCGB1A1 SFTPB
8 cardiocranial syndrome 10.6 CXCL8 ELANE
9 congenital insensitivity to pain with hyperhidrosis 10.6 CXCL8 IL1RN
10 pediculus humanus corporis infestation 10.6 SCGB1A1 SFTPB
11 labyrinthine bilateral reactive loss 10.5 CXCL8 ELANE
12 tuberculous salpingitis 10.5 CXCL8 TIMP1
13 orthostatic proteinuria 10.5 CXCL8 IL1RN
14 papular elastorrhexis 10.4 ELANE TIMP1
15 adenocarcinoid tumor 10.4 CXCL8 ELANE SFTPB
16 chromoblastomycosis 10.4 ELANE SELL
17 pulmonary hypertension 10.4
18 granulomatous rosacea 10.4 ITGAM SELL
19 pasteurellosis 10.4 CXCL8 SCGB1A1 SFTPB
20 idiopathic progressive polyneuropathy 10.4 FLT1 SOD1
21 hyperlucent lung 10.4 ELANE FLT1
22 asbestosis 10.3 CXCL8 SCGB1A1 SOD1
23 acute erythroid leukemia 10.3 CXCL8 IL1RN RBP4
24 cone-rod dystrophy 16 10.3 ITGAM SELL
25 lung papillary adenocarcinoma 10.3 CXCL8 TIMP1
26 bullous skin disease 10.3 CXCL8 ELANE SFTPB
27 senile reticular retinal degeneration 10.3 CXCL8 IL1RN
28 granulomatous orchitis 10.3 CXCL8 SFTPB TIMP1
29 sinusitis 10.3 CXCL8 IL1RN SCGB1A1
30 chorioamnionitis 10.3
31 goodpasture syndrome 10.2 CXCL8 IL1RN SELL
32 endotheliitis 10.2
33 anogenital venereal wart 10.2 ELANE SCGB1A1 SFTPB
34 vulva fibroepithelial polyp 10.2 CXCL8 ELANE TIMP1
35 lens disease 10.2 FLT1 IL1RN
36 breast adenomyoepithelioma 10.2 ELANE TIMP1
37 mesenchymal cell neoplasm 10.2 CXCL8 IL1RN TIMP1
38 ulnar neuropathy 10.2 FLT1 TIMP1
39 burn scar 10.2 CXCL8 SCGB1A1 TIMP1
40 neonatal period electroclinical syndrome 10.2 CXCL8 ELANE FLT1
41 steatorrhea 10.2 CXCL8 TIMP1
42 diamond-blackfan anemia 1 10.1 ELANE SELL TIMP1
43 macroglobulinemia, waldenstrom 1 10.1 CXCL8 ELANE ITGAM
44 craniopharyngioma 10.1 ITGAM SELL
45 lung disease 10.1
46 personality disorder 10.1
47 cholera 10.1 ELANE TIMP1
48 alcoholic pancreatitis 10.0 ELANE RNASE3
49 adenoid squamous cell carcinoma 10.0 CXCL8 ELANE SCGB1A1 SFTPB
50 patent ductus arteriosus 10.0

Graphical network of the top 20 diseases related to Bronchopulmonary Dysplasia:



Diseases related to Bronchopulmonary Dysplasia

Symptoms & Phenotypes for Bronchopulmonary Dysplasia

MGI Mouse Phenotypes related to Bronchopulmonary Dysplasia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.9 SCGB1A1 SELL SFTPB SOD1 TIMP1 ELANE
2 hematopoietic system MP:0005397 9.86 ELANE FGF10 FLT1 IL1RN ITGAM SELL
3 immune system MP:0005387 9.61 ELANE FGF10 FLT1 IL1RN ITGAM SCGB1A1
4 neoplasm MP:0002006 9.02 ELANE SCGB1A1 SELL SOD1 TIMP1

Drugs & Therapeutics for Bronchopulmonary Dysplasia

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
RespiGam 17 MedImmune January 1996

Drugs for Bronchopulmonary Dysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 220)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaterol Approved Phase 4 72332-33-3 688561
2 Beractant Approved Phase 4,Phase 2,Phase 3 108778-82-1
3
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1 51333-22-3 63006 5281004
4 Poractant alfa Approved Phase 4,Phase 2,Phase 3 129069-19-8
5
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2 57-83-0 5994
6
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
7
Remifentanil Approved Phase 4,Phase 1,Phase 2 132875-61-7 60815
8
Caffeine Approved, Nutraceutical Phase 4,Phase 3 58-08-2 2519
9 Adrenergic Agents Phase 4
10 Adrenergic Agonists Phase 4
11 Adrenergic beta-2 Receptor Agonists Phase 4
12 Adrenergic beta-Agonists Phase 4
13 Albuterol Phase 4
14 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Tocolytic Agents Phase 4,Phase 3,Phase 2
21 Pulmonary Surfactants Phase 4,Phase 3,Phase 2,Phase 1
22 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
23 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
24 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
25 Hormones Phase 4,Phase 3,Phase 2,Phase 1
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
27 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Lactoferrin Phase 4
29 Antibodies Phase 4,Phase 3
30 Immunoglobulins Phase 4,Phase 3
31 Vaccines Phase 4
32 11-hydroxyprogesterone Phase 4,Phase 2,Phase 3
33 17-alpha-hydroxy-progesterone caproate Phase 4,Phase 2,Phase 3
34 Estrogen Antagonists Phase 4,Phase 2,Phase 3
35 Estrogens Phase 4,Phase 2,Phase 3
36 Progestins Phase 4,Phase 3,Phase 2
37 Anticoagulants Phase 4,Phase 3
38 Caffeine citrate Phase 4,Phase 3
39 Central Nervous System Stimulants Phase 4,Phase 3
40 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2
41 Purinergic P1 Receptor Antagonists Phase 4,Phase 3
42 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
43 Calcium, Dietary Phase 4
44 Chelating Agents Phase 4
45 Analgesics, Opioid Phase 4,Phase 1,Phase 2
46 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2
47 Anesthetics, General Phase 4,Phase 1,Phase 2
48 Anesthetics, Intravenous Phase 4,Phase 1,Phase 2
49 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2
50 Hypnotics and Sedatives Phase 4,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 288)

id Name Status NCT ID Phase Drugs
1 Preterm Infant Inhaled Albuterol Dosing Unknown status NCT02447250 Phase 4 Varied albuterol dose response
2 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
3 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
4 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
5 The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary Dysplasia Completed NCT00926276 Phase 4
6 Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis Completed NCT02959229 Phase 4 Lactoferrin;Placebo (for Lactoferrin)
7 Prevention of RSV Infections in Bone Marrow Transplant Recipients Completed NCT00001903 Phase 4 RSV Polyclonal Immunoglobulin
8 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
9 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
10 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
11 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
12 Early Caffeine in Preterm Neonates Recruiting NCT03086473 Phase 4 Caffeine Citrate;Placebo (Normal Saline)
13 Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome Recruiting NCT02164734 Phase 4 remifentanil
14 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part III Recruiting NCT01604434 Phase 4
15 Exogenous Surfactant in Very Preterm Neonates in Prevention of Bronchopulmonary Dysplasia Active, not recruiting NCT01039285 Phase 4 Curosurf
16 Rate of Bronchopulmonary Dysplasia in Preterms Neonates: a Trial Comparing SMOFlipid and Medialipide Not yet recruiting NCT02853253 Phase 4
17 Intratracheal Budesonide/Surfactant Prevents BPD Not yet recruiting NCT03275415 Phase 4 budesonide;Saline
18 Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants Terminated NCT00767039 Phase 4 Survanta (beractant);Curosurf (poractant)
19 Clarithromycin Prophylaxis in Preterm Infants Colonisation With Ureaplasma Urealyticum and Mycoplasma Hominis Unknown status NCT01652118 Phase 3 clarithromycin treatment for prophylaxis of bronchopulmonary dysplasia;Saline
20 Trial of Late Surfactant for Prevention of Bronchopulmonary Dysplasia Unknown status NCT01022580 Phase 3 Infasurf surfactant (ONY, Inc.)
21 Cysteine Supplementation in Critically Ill Neonates Unknown status NCT00254176 Phase 2, Phase 3
22 Efficacy and Safety of Inhaled Budesonide in Very Preterm Infants at Risk for Bronchopulmonary Dysplasia Completed NCT01035190 Phase 3 Budesonide
23 PREMILOC Trial to Prevent Bronchopulmonary Dysplasia in Very Preterm Neonates Completed NCT00623740 Phase 3 hydrocortisone;placebo
24 Inhaled Nitric Oxide (INO) for the Prevention of Bronchopulmonary Dysplasia (BPD) in Preterm Infants Completed NCT00931632 Phase 3 Inhaled Nitric Oxide;Placebo
25 Inhaled Nitric Oxide to Prevent and Treat Bronchopulmonary Dysplasia Completed NCT01503801 Phase 2, Phase 3 Nitric Oxide
26 Phase III Randomized, Double-Blind Study of Dexamethasone Vs Dexamethasone/Methylprednisolone Vs Placebo for Bronchopulmonary Dysplasia Completed NCT00004785 Phase 3 dexamethasone;methylprednisolone
27 Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV) Completed NCT00433212 Phase 3
28 Inhaled Beclomethasone to Prevent Chronic Lung Disease Completed NCT00000576 Phase 3 beclomethasone
29 Post-Hospitalization Nursing Effectiveness (PHONE) Study Completed NCT00314431 Phase 3
30 Exosurf Neonatal and Survanta for Treatment of Respiratory Distress Syndrome Completed NCT01203358 Phase 2, Phase 3 Exosurf;Survanta
31 Inhaled NO in Prevention of Chronic Lung Disease Completed NCT00000548 Phase 3
32 Trial of Late Surfactant to Prevent BPD: A Pilot Study in Ventilated Preterm Neonates Receiving Inhaled Nitric Oxide Completed NCT00569530 Phase 3 Infasurf (ONY Inc.);Sham
33 Inhaled Nitric Oxide for Preventing Chronic Lung Disease in Premature Infants Completed NCT00006401 Phase 3 iNO
34 Randomized Trial of Nasal Continuous Positive Airway Pressure or Synchronized Nasal Ventilation in Premature Infants. Completed NCT00188968 Phase 3
35 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Completed NCT00233324 Phase 3 Surfactant;Supplemental oxygen with target saturation of 85 to 89%;Supplemental oxygen with target saturation of 91 to 95%
36 Vitamin D Supplementation for Extremely Preterm Infants Completed NCT01600430 Phase 2, Phase 3
37 High Frequency Ventilation in Premature Infants (HIFI) Completed NCT00000567 Phase 3
38 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
39 Palivizumab for Prevention of Severe Respiratory Syncytial Virus Infection in Russian Children Completed NCT01006629 Phase 2, Phase 3
40 The Effect of Sildenafil in Preterm Infants With Evolving Chronic Lung Disease Completed NCT00431418 Phase 3 Sildenafil;Placebo
41 Dexamethasone Therapy in VLBW Infants at Risk of CLD Completed NCT00011362 Phase 3 Dexamethasone Early;Dexamethasone Late
42 Safety and Efficacy Study of Nitric Oxide for Inhalation on Chronic Lung Disease in Premature Babies Completed NCT00551642 Phase 3 Nitric Oxide for inhalation;Nitrogen
43 A Multicenter, Randomized, Open Label Trial of a New Animal Extracted Surfactant to Treat RDS in Preterm Infants Completed NCT02305160 Phase 2, Phase 3 Butantan;Control
44 Prolonged Outcomes After Nitric Oxide (PrONOx) Completed NCT00234247 Phase 3
45 Safety Study of Home Oxygen Therapy for Children With Acute Bronchiolitis Completed NCT00677066 Phase 3
46 Intravenous Immunoglobulin in Prevention of Preterm Neonatal Sepsis Completed NCT02954926 Phase 3 IVIG
47 PREGNANT Short Cervix Trial Completed NCT00615550 Phase 3 progesterone;placebo
48 A Study to Assess the Safety and Effectiveness of Palivizumab Administered to Children at High Risk of Severe Respiratory Syncytial Virus (RSV) Infection in the Russian Federation and the Republic of Belarus Completed NCT02968173 Phase 3 Palivizumab
49 Oxygen Toxicity in the Resuscitation in Extremely Premature Infants Completed NCT00494702 Phase 3
50 Caffeine for Apnea of Prematurity (CAP) Completed NCT00182312 Phase 3 Caffeine citrate injection

Search NIH Clinical Center for Bronchopulmonary Dysplasia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bronchopulmonary Dysplasia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchopulmonary Dysplasia:
PNEUMOSTEM

Genetic Tests for Bronchopulmonary Dysplasia

Anatomical Context for Bronchopulmonary Dysplasia

MalaCards organs/tissues related to Bronchopulmonary Dysplasia:

39
Lung, Brain, Endothelial, Cervix, Bone, Heart, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Bronchopulmonary Dysplasia:
id Tissue Anatomical CompartmentCell Relevance
1 Lung Alveoli Alveolar Epithelial Type 1 Cells Potential therapeutic candidate, affected by disease
2 Lung Alveoli Alveolar Epithelial Type 2 Cells Potential therapeutic candidate, affected by disease
3 Lung Pulmonary Capillary Plexus Affected by disease

Publications for Bronchopulmonary Dysplasia

Articles related to Bronchopulmonary Dysplasia:

(show top 50) (show all 733)
id Title Authors Year
1
Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. ( 28851267 )
2017
2
Bronchopulmonary dysplasia and pulmonary hypertension: a meta-analysis. ( 28079864 )
2017
3
Biomarkers associated with bronchopulmonary dysplasia/mortality in premature infants. ( 27893721 )
2017
4
Late (a8Y 7 days) inhalation corticosteroids to reduce bronchopulmonary dysplasia in preterm infants. ( 28836266 )
2017
5
Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia? ( 28861110 )
2017
6
Impact of Diuretic Therapy in the Treatment of Bronchopulmonary Dysplasia and Acute Kidney Injury in the Neonatal Population. ( 28857765 )
2017
7
Can We Prevent Bronchopulmonary Dysplasia? ( 28947055 )
2017
8
The economic impact of prematurity and bronchopulmonary dysplasia. ( 28889192 )
2017
9
Genome-wide association study of bronchopulmonary dysplasia: a potential role for variants near the CRP gene. ( 28839172 )
2017
10
Respiratory outcomes after initial hospital discharge in children with ventricular shunts and bronchopulmonary dysplasia. ( 28941226 )
2017
11
Tracheobronchomalacia Is Associated with Increased Morbidity in Bronchopulmonary Dysplasia. ( 28622012 )
2017
12
Therapeutic effects of fibroblast growth factor-10 on hyperoxia-induced bronchopulmonary dysplasia in neonatal mice. ( 28861146 )
2017
13
Histologic Chorioamnionitis and Bronchopulmonary Dysplasia in Preterm Infants: The Epidemiologic Study on Low Gestational Ages 2 Cohort. ( 28583707 )
2017
14
Bronchopulmonary dysplasia-associated pulmonary hypertension: clues from placental pathology. ( 28880261 )
2017
15
Modelling bronchopulmonary dysplasia in animals: arguments for the preterm rabbit model. ( 28950821 )
2017
16
Can We Cure Bronchopulmonary Dysplasia? ( 28942897 )
2017
17
Bronchopulmonary dysplasia: incidence and risk factors. ( 28895695 )
2017
18
Bronchopulmonary Dysplasia. ( 28855707 )
2017
19
GSTP1 and CYP2B6 Genetic Polymorphisms and the Risk of Bronchopulmonary Dysplasia in Preterm Neonates. ( 28081574 )
2017
20
Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function Through Macrophage Immunomodulation. ( 28853608 )
2017
21
Mesenchymal stem cells in the pathogenesis and treatment of bronchopulmonary dysplasia: A clinical review. ( 28945702 )
2017
22
Trends of urinary beta-2-microglobulin levels and bronchopulmonary dysplasia in preterm infants. ( 28833913 )
2017
23
Bronchopulmonary Dysplasia: Chronic Lung Disease of Infancy and Long-Term Pulmonary Outcomes. ( 28067830 )
2017
24
Pulmonary vein stenosis of ex-premature infants with pulmonary hypertension and bronchopulmonary dysplasia, epidemiology, and survival from a multicenter cohort. ( 28152279 )
2017
25
Effects of the early administration of sivelestat sodium on bronchopulmonary dysplasia in infants: A retrospective cohort study. ( 28950234 )
2017
26
Medical Progress Series: Bronchopulmonary Dysplasia at 50 Years-An Introduction. ( 28843303 )
2017
27
An Elevation of Serum Ferritin Level Might Increase Clinical Risk for the Persistence of Patent Ductus Arteriosus, Sepsis and Bronchopulmonary Dysplasia in Erythropoietin-Treated Very-Low-Birth-Weight Infants. ( 27547966 )
2016
28
Ascorbylperoxide Contaminating Parenteral Nutrition Is Associated With Bronchopulmonary Dysplasia or Death in Extremely Preterm Infants. ( 27036126 )
2016
29
Sildenafil, pulmonary hypertension and bronchopulmonary dysplasia. ( 27665322 )
2016
30
Impact of bronchopulmonary dysplasia on brain and retina. ( 26988760 )
2016
31
Early inhaled nitric oxide in preterm infants <34 weeks with evolving bronchopulmonary dysplasia. ( 27442155 )
2016
32
Lung CT imaging in patients with bronchopulmonary dysplasia: A systematic review. ( 27148803 )
2016
33
Circulating Fibrocytes Are Increased in Neonates with Bronchopulmonary Dysplasia. ( 27309347 )
2016
34
Looking ahead: where to next for animal models of bronchopulmonary dysplasia? ( 27917436 )
2016
35
Pathophysiology, screening and diagnosis of pulmonary hypertension in infants with bronchopulmonary dysplasia - A review of the literature. ( 27986502 )
2016
36
Association between Hemoglobin Levels in the First 3 Days of Life and Bronchopulmonary Dysplasia in Preterm Infants. ( 27120476 )
2016
37
Modelling bronchopulmonary dysplasia in mice: how much oxygen is enough? ( 28067624 )
2016
38
Human mesenchymal stem cells attenuate experimental bronchopulmonary dysplasia induced by perinatal inflammation and hyperoxia. ( 27158330 )
2016
39
Inhaled Corticosteroids for Bronchopulmonary Dysplasia: A Meta-analysis. ( 27940717 )
2016
40
Diffusing Capacity in Bronchopulmonary Dysplasia. Can Function Determine Structure? ( 27035779 )
2016
41
Neurally Adjusted Ventilatory Assist in Preterm Infants With Established or Evolving Bronchopulmonary Dysplasia on High-Intensity Mechanical Ventilatory Support: A Single-Center Experience. ( 27918385 )
2016
42
Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants. ( 27117196 )
2016
43
Expression of transforming growth factor-I^1 in neonatal rats with hyperoxia-induced bronchopulmonary dysplasia and its relationship with lung development. ( 27173325 )
2016
44
Prophylactic low-dose hydrocortisone treatment increases the rate of survival without bronchopulmonary dysplasia in extremely preterm infants. ( 27516373 )
2016
45
Long-Term Outcomes of Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia. ( 27172918 )
2016
46
Vitamin A Supplementation for Prevention of Bronchopulmonary Dysplasia: Cornerstone of Care or Futile Therapy? ( 27147702 )
2016
47
MicroRNA in late lung development and bronchopulmonary dysplasia: the need to demonstrate causality. ( 27216745 )
2016
48
Commentary: A Breath of Fresh Air on the Mesenchyme: Impact of Impaired Mesenchymal Development on the Pathogenesis of Bronchopulmonary Dysplasia. ( 27066487 )
2016
49
Impact of pulmonary hypertension on neurodevelopmental outcome in preterm infants with bronchopulmonary dysplasia: a cohort study. ( 27442157 )
2016
50
Cellular and humoral biomarkers of Bronchopulmonary Dysplasia. ( 27989587 )
2016

Variations for Bronchopulmonary Dysplasia

Expression for Bronchopulmonary Dysplasia

Search GEO for disease gene expression data for Bronchopulmonary Dysplasia.

Pathways for Bronchopulmonary Dysplasia

Pathways related to Bronchopulmonary Dysplasia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.51 CXCL8 ELANE FLT1 ITGAM
2 11.39 CXCL8 ITGAM TIMP1
3 10.49 CXCL8 IL1RN TIMP1

GO Terms for Bronchopulmonary Dysplasia

Cellular components related to Bronchopulmonary Dysplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 ELANE IL1RN ITGAM RBP4 RNASE3 SCGB1A1
2 extracellular region GO:0005576 9.7 CXCL8 ELANE FGF10 FLT1 IL1RN RBP4
3 extracellular space GO:0005615 9.4 CXCL8 ELANE FGF10 FLT1 IL1RN ITGAM
4 secretory granule GO:0030141 9.33 ELANE SCGB1A1 SOD1

Biological processes related to Bronchopulmonary Dysplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.73 ELANE ITGAM RNASE3 SELL
2 response to lipopolysaccharide GO:0032496 9.65 ELANE FGF10 SCGB1A1
3 chemotaxis GO:0006935 9.58 CXCL8 FGF10 FLT1
4 blood vessel morphogenesis GO:0048514 9.46 FGF10 FLT1
5 embryonic digestive tract development GO:0048566 9.37 CXCL8 FGF10
6 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.32 FGF10 FLT1
7 induction of positive chemotaxis GO:0050930 9.26 CXCL8 FGF10
8 response to organic substance GO:0010033 9.13 SCGB1A1 SOD1 TIMP1
9 positive regulation of superoxide anion generation GO:0032930 8.85 SOD1
10 female genitalia morphogenesis GO:0048807 8.62 FGF10 RBP4

Molecular functions related to Bronchopulmonary Dysplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.13 ELANE FGF10 SELL
2 protease binding GO:0002020 8.8 ELANE SELL TIMP1

Sources for Bronchopulmonary Dysplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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