MCID: BRN120
MIFTS: 37

Bronchus Cancer

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Bronchus Cancer

MalaCards integrated aliases for Bronchus Cancer:

Name: Bronchus Cancer 12 14
Bronchial Neoplasms 42 69
Bronchus Carcinoma 12 14
Bronchial Neoplasm 12 14
Malignant Neoplasm of Bronchus and Lung, Unspecified 12
Malignant Neoplasm of Bronchus or Lung, Unspecified 12
Malignant Neoplasm of Bronchus or Lung Nos 12
Bc - Bronchogenic Carcinoma 12
Carcinoma, Bronchogenic 42
Bronchogenic Carcinoma 69
Neoplasm of Bronchus 12
Bronchus Neoplasm 12

Classifications:



Summaries for Bronchus Cancer

Disease Ontology : 12 A bronchus cancer that has material basis in epithelial cells.

MalaCards based summary : Bronchus Cancer, also known as bronchial neoplasms, is related to main bronchus cancer and bronchus carcinoma in situ, and has symptoms including coughing, dyspnea and fever. An important gene associated with Bronchus Cancer is CD6 (CD6 Molecule), and among its related pathways/superpathways is Vasopressin-regulated water reabsorption. The drugs Tranexamic Acid and Antifibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include lung and testes, and related phenotype is Decreased viability.

Related Diseases for Bronchus Cancer

Diseases in the Bronchus Cancer family:

Bronchus Carcinoma in Situ

Diseases related to Bronchus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
id Related Disease Score Top Affiliating Genes
1 main bronchus cancer 12.1
2 bronchus carcinoma in situ 11.9
3 lung cancer 10.9
4 bronchus mucoepidermoid carcinoma 10.9
5 porokeratosis 3, multiple types 10.3 CRP SAA1
6 smooth muscle tumor 10.2 AVPR2 CD6
7 amyloidosis nodular localized cutaneous 10.2 CRP SAA1
8 pulmonary blastoma 10.1
9 pleuropulmonary blastoma type 1 10.1
10 pleuropulmonary blastoma type 2 10.1
11 pleuropulmonary blastoma type 3 10.1
12 meester-loeys syndrome 10.1 AVP AVPR2
13 familial mediterranean fever, ad 10.1 CRP SAA1
14 carotid artery thrombosis 10.1 AVP AVPR2
15 myelomeningocele 10.1 AVP CRP
16 prediabetes syndrome 10.0 AVP AVPR2
17 synovial chondromatosis 10.0 AVP AVPR2
18 congenital syphilis 10.0 AVP CRP
19 integrative agnosia 10.0 CD6 ENO2
20 retinitis pigmentosa 46 10.0 AVP AVPR2
21 active cochleovestibular meniere's disease 10.0 CD6 ENO2
22 microcephaly 8, primary, autosomal recessive 10.0 AVP CRP
23 hypertrophic elongation of cervix 10.0 AVP CRP
24 urethral gland abscess 9.9 CRP ENO2
25 chondroma 9.9 AVP CRP
26 mast cell neoplasm 9.8 AVP ENO2
27 benign pericardial teratoma 9.8 AVP ENO2
28 mucin-rich endometrial endometrioid adenocarcinoma 9.8 AVPR2 ENO2
29 palmoplantar keratoderma, bothnian type 9.8 AVP AVPR2
30 bronchiectasis 9.8
31 nose disease 9.7 AVP ENO2
32 actinomycosis 9.7
33 spastic entropion 9.7 CRP ENO2
34 hypertensive encephalopathy 9.7 AVP AVPR2
35 internal auditory canal lipoma 9.7 AVP ENO2
36 louping ill 9.7 CRP ENO2
37 endocervical type cervical mucinous adenocarcinoma 9.6 CRP ENO2
38 calcinosis 9.6 AVP CRP
39 situs inversus 9.6
40 superior vena cava syndrome 9.6
41 mediastinitis 9.6
42 esophagitis 9.6
43 cushing's syndrome 9.6
44 mucoepidermoid carcinoma 9.6
45 achalasia 9.6
46 adenoiditis 9.6
47 histiocytosis 9.6
48 leprosy 6 9.4 AVP ENO2
49 umbilical hernia 9.1 AVP ENO2
50 diverticulitis of colon 7.9 AVP AVPR2 CD6 CRP ENO2 SAA1

Graphical network of the top 20 diseases related to Bronchus Cancer:



Diseases related to Bronchus Cancer

Symptoms & Phenotypes for Bronchus Cancer

UMLS symptoms related to Bronchus Cancer:


coughing, dyspnea, fever, hemoptysis

GenomeRNAi Phenotypes related to Bronchus Cancer according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 8.92 AVPR2 SAA1
2 Decreased viability GR00381-A-3 8.92 AVPR2 SAA1

Drugs & Therapeutics for Bronchus Cancer

Drugs for Bronchus Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 3 1197-18-8 5526
2 Antifibrinolytic Agents Phase 3
3 Coagulants Phase 3
4 Hemostatics Phase 3
5
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
6
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
7 Protein Kinase Inhibitors Phase 2
8 Alkylating Agents Phase 2
9 Bendamustine Hydrochloride Phase 2
10 Anti-Allergic Agents Phase 2
11 Anti-Asthmatic Agents Phase 2
12 Anti-Inflammatory Agents Phase 2
13 Autonomic Agents Phase 2
14 Bronchodilator Agents Phase 2
15 Dermatologic Agents Phase 2,Phase 1
16
Fluticasone Phase 2 90566-53-3, 80474-14-2 62924 22833648
17 Peripheral Nervous System Agents Phase 2
18 Respiratory System Agents Phase 2
19 Antidotes Phase 2
20 Anti-Infective Agents Phase 2
21 Antioxidants Phase 2
22 Antiviral Agents Phase 2
23 Expectorants Phase 2
24 N-monoacetylcystine Phase 2
25 Protective Agents Phase 2
26
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
27 Hematoporphyrin Derivative Phase 1
28 Hematoporphyrins Phase 1
29 Photosensitizing Agents Phase 1
30 HIV Protease Inhibitors Phase 1
31
protease inhibitors Phase 1
32 Proteasome Inhibitors Phase 1
33
Gabapentin Approved, Investigational 60142-96-3 3446
34
Trioxsalen Approved 3902-71-4 5585
35
Menthol Approved 2216-51-5 16666
36
gamma-Aminobutyric acid Investigational 56-12-2 119
37 Analgesics
38 Anti-Anxiety Agents
39 Anticonvulsants
40 Antimanic Agents
41 Antiparkinson Agents
42 calcium channel blockers
43 Calcium, Dietary
44 Central Nervous System Depressants
45 Excitatory Amino Acid Antagonists
46 Excitatory Amino Acids
47 GABA Agents
48 Neurotransmitter Agents
49 Psychotropic Drugs
50 Tranquilizing Agents

Interventional clinical trials:

(show all 40)

id Name Status NCT ID Phase Drugs
1 Role of a Silicone Prosthesis to Prevent Airway Obstruction Recurrence in Lung Cancers Terminated NCT01064050 Phase 4
2 A New Pathway With BronchOscopic or Oesophageal Ultrasound for Lung Cancer Diagnosis and STaging (BOOST) Unknown status NCT00652769 Phase 3
3 The Role of Inhalations of Tranexamic Acid in Patients With Hemoptysis Unknown status NCT01496196 Phase 3 tranexamic acid;tranexamic acid
4 Comparing Diagnostic Yield Between R-EBUS Guided Cryo Biopsy Vs. CT Guided Biopsy for PPL Recruiting NCT02395939 Phase 3
5 Efficacy and Safety Study of Gefitinib in Squamous NSCLC Patients Who Failed First-Line Chemotherapy Unknown status NCT01485809 Phase 2 Gefitinib
6 Study to Determine the Efficacy of Bendamustin in Patients With Recurrent Small Cell Lung Cancer (SCLC) Unknown status NCT00168922 Phase 2 Bendamustin/Ribomustin
7 Randomized Trial of Fluticasone in Bronchial Premalignancy Completed NCT00407264 Phase 2 Fluticasone propionate
8 Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training Completed NCT00196885 Phase 2 N-acetylcysteine
9 Phase 2 Study Of Neoadjuvant Iressa Treatment In Stage 1 NSCLC Completed NCT00188617 Phase 2 GEFITINIB
10 RejuvenAir Lobectomy for Safety and Histology Completed NCT02483052 Phase 1, Phase 2
11 Stereotactic Body Radiation Therapy for Un-biopsied Early- Stage Non Small Cell Lung Cancer Recruiting NCT02950337 Phase 2
12 CyberKnife Radiosurgical Treatment of Inoperable Early Stage Non-Small Cell Lung Cancer Active, not recruiting NCT00643318 Phase 2
13 Photodynamic Therapy Plus Brachytherapy in Treating Patients With Lung Cancer Completed NCT00014066 Phase 1 hematoporphyrin derivative
14 Photodynamic Therapy Using HPPH in Treating Patients With Stage 0 Non-Small Cell Lung Cancer Completed NCT00526461 Phase 1 HPPH
15 Diagnostic Effectiveness of Virtual Bronchoscopy Completed NCT00001515 Phase 1
16 PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck Completed NCT00011778 Phase 1 bortezomib
17 Tumor Bank for Tissue Samples Unknown status NCT01789229
18 Tumor Bank for Blood Samples Unknown status NCT01763125
19 Feasibility of the Research for Mutation of K-ras and EGFR in CTCs From Metastatic Non Small Cells Bronchial Carcinomas Completed NCT01380795 Early Phase 1
20 Ultra-Violet Fluorescence Bronchial Cancer Location Completed NCT02533518
21 Study of the Fixation of Various Vectors in PET/CT in Patients With a With Lung Cancer Before and During of CRT or RT Completed NCT01261585
22 Tumour Registry Lung Cancer (TLK) Completed NCT01192919
23 Siemens VOC TB Pilot Study Completed NCT01748357
24 Evaluation of a LAM FLISA for the Diagnosis of Tuberculosis Completed NCT01587677
25 Cancer in Patients With Gabapentin (GPRD) Completed NCT01236053 Gabapentin prescriptions
26 Breath Testing in Early and Late Larynx Cancer Completed NCT01700647
27 Photodynamic Therapy (PDT) in Lung Cancer Completed NCT00984243
28 SAS in Patients With Bronchial Carcinoma Recruiting NCT02270853
29 Whole Body Electromyostimulation and Nutritional Therapy for Patients With Esophageal and Bronchial Carcinoma Recruiting NCT03274349
30 Therapeutic CARE of the Bronchial Cancer Not in Small Cell: Implementation of a Coordination Card of Care Relative to the Medicinal Treatments Got Out of it From Hospitalization Recruiting NCT03293966
31 Sensory Approach of Food Modifications Led by Chemotherapy Recruiting NCT02368509
32 Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers Recruiting NCT00188890
33 Prospective Follow-up of Outcomes in Patients Receiving Photodynamic Therapy for Neoplastic Diseases Recruiting NCT02159742
34 Type 1 Multiple Endocrine Neoplasia Cohort Study Recruiting NCT03262129
35 Veterans Affairs Lung Cancer Or Stereotactic Radiotherapy Recruiting NCT02984761
36 Study of the Quality of Lung Resection Active, not recruiting NCT02877043
37 Pilot Study To Evaluate Optical Frequency Domain Imaging For Diagnosis Of Central Airway Disease Active, not recruiting NCT00784329
38 Prevalence of Sleep-disordered Breathing in Patients With a Newly Diagnosed Non Small Cell Lung Cancer Not yet recruiting NCT02648087
39 Evolution of Indications for Transbronchial Ganglionic Ultrasound in the Picardie Region Over the Period 2008 - 2013 Not yet recruiting NCT03132883
40 Bronchoscopy With Bronchoalveolar Lavage in Identifying Biomarkers of Response to Immune Checkpoint Inhibitors in Patients With Non-small Cell or Small Cell Lung Cancer Not yet recruiting NCT02937402

Search NIH Clinical Center for Bronchus Cancer

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: bronchial neoplasms

Genetic Tests for Bronchus Cancer

Anatomical Context for Bronchus Cancer

MalaCards organs/tissues related to Bronchus Cancer:

39
Lung, Testes

Publications for Bronchus Cancer

Articles related to Bronchus Cancer:

(show all 11)
id Title Authors Year
1
Dosimetric impact of an air passage on intraluminal brachytherapy for bronchus cancer. ( 27605630 )
2016
2
Racial and Gender Disparities in Incidence of Lung and Bronchus Cancer in the United States: A Longitudinal Analysis. ( 27685944 )
2016
3
Incidence rates for lung and bronchus cancer of Japanese in Japan and in the United States from the Cancer Incidence in Five Continents. ( 27380807 )
2016
4
Stat Bite Percentage of New Caces by Age Group For Lung and Bronchus Cancer (2008-2012). ( 26944763 )
2016
5
Lung and bronchus cancer in Puerto Rico: changes in incidence and mortality rates by histology and sex during 1987-2003: comment on the article by Rivas et al. ( 22783701 )
2012
6
Lung and bronchus cancer in Puerto Rico: changes in incidence and mortality rates by histology and sex during 1987-2003. ( 22263297 )
2011
7
Superior vena cava syndrome in a man with situs inversus totalis and left main bronchus cancer. ( 19507488 )
2009
8
Stat bite: Mortality from lung and bronchus cancer by race/ethnicity, 1998-2002. ( 16449672 )
2006
9
Lung and bronchus cancer disparities in South Carolina: epidemiology and strategies for prevention. ( 17319229 )
2006
10
Stat bite: Incidence of lung and bronchus cancer by ethnicity, 1996-2000. ( 12902435 )
2003
11
Lung and bronchus cancer in women: a 21st-century epidemic. ( 12370622 )
2002

Variations for Bronchus Cancer

Cosmic variations for Bronchus Cancer:

9
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM10656 TP53 lung,bronchus,carcinoma,NS c.742C>T p.R248W 15
2 COSM10660 TP53 lung,bronchus,carcinoma,NS c.818G>A p.R273H 15
3 COSM10718 TP53 lung,bronchus,carcinoma,NS c.524G>T p.R175L 15
4 COSM10662 TP53 lung,bronchus,carcinoma,NS c.743G>A p.R248Q 15
5 COSM10779 TP53 lung,bronchus,carcinoma,NS c.818G>T p.R273L 15
6 COSM6213 EGFR lung,bronchus,carcinoma,NS c.2582T>A p.L861Q 15

Expression for Bronchus Cancer

Search GEO for disease gene expression data for Bronchus Cancer.

Pathways for Bronchus Cancer

Pathways related to Bronchus Cancer according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.27 AVP AVPR2

GO Terms for Bronchus Cancer

Cellular components related to Bronchus Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 AVP CRP ENO2 SAA1
2 clathrin-coated vesicle membrane GO:0030665 8.62 AVP AVPR2

Biological processes related to Bronchus Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.5 AVP AVPR2 CRP
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.37 AVP SAA1
3 acute-phase response GO:0006953 9.26 CRP SAA1
4 positive regulation of vasoconstriction GO:0045907 9.16 AVP AVPR2
5 renal water homeostasis GO:0003091 8.96 AVP AVPR2
6 positive regulation of systemic arterial blood pressure GO:0003084 8.62 AVP AVPR2

Sources for Bronchus Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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