MCID: BRW007
MIFTS: 9

Brown Oca

Categories: Genetic diseases

Aliases & Classifications for Brown Oca

MalaCards integrated aliases for Brown Oca:

Name: Brown Oca 24

Classifications:



Summaries for Brown Oca

MalaCards based summary : Brown Oca is related to albinism, oculocutaneous, type ii and albinism, oculocutaneous, type iii. An important gene associated with Brown Oca is OCA2 (OCA2 Melanosomal Transmembrane Protein). The drugs chenodeoxycholic acid and Cathartics have been mentioned in the context of this disorder. Affiliated tissues include liver.

Related Diseases for Brown Oca

Diseases related to Brown Oca via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 albinism, oculocutaneous, type ii 11.1
2 albinism, oculocutaneous, type iii 11.0

Symptoms & Phenotypes for Brown Oca

Drugs & Therapeutics for Brown Oca

Drugs for Brown Oca (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
chenodeoxycholic acid Approved Phase 4 474-25-9 10133
2 Cathartics Phase 4
3 Gastrointestinal Agents Phase 4
4 Laxatives Phase 4
5 Liver Extracts Phase 4
6 Mirabegron Approved Phase 3 223673-61-8
7 Adrenergic Agents Phase 3
8 Adrenergic Agonists Phase 3
9 Adrenergic beta-3 Receptor Agonists Phase 3
10 Adrenergic beta-Agonists Phase 3
11 Cholinergic Agents Phase 3
12 Cholinergic Antagonists Phase 3
13 Muscarinic Antagonists Phase 3
14 Neurotransmitter Agents Phase 3
15 Solifenacin succinate Phase 3 242478-38-2
16
Atrasentan Phase 3 173937-91-2, 195733-43-8 159594
17 Endothelin Receptor Antagonists Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
2 A Trial Comparing Combination Treatment (Solifenacin Plus Mirabegron) With One Treatment Alone (Solifenacin) Completed NCT01908829 Phase 3 mirabegron 25 mg;mirabegron 50 mg;solifenacin 5 mg;solifenacin 10 mg;mirabegron 25 mg matching placebo;mirabegron 50 mg matching placebo;solifenacin 5 mg matching placebo;solifenacin 10 mg matching placebo
3 Study Of Diabetic Nephropathy With Atrasentan Active, not recruiting NCT01858532 Phase 3 Atrasentan;Placebo

Search NIH Clinical Center for Brown Oca

Genetic Tests for Brown Oca

Genetic tests related to Brown Oca:

id Genetic test Affiliating Genes
1 Brown Oca 24

Anatomical Context for Brown Oca

MalaCards organs/tissues related to Brown Oca:

39
Liver

Publications for Brown Oca

Variations for Brown Oca

Expression for Brown Oca

Search GEO for disease gene expression data for Brown Oca.

Pathways for Brown Oca

GO Terms for Brown Oca

Sources for Brown Oca

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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