MCID: BRW006
MIFTS: 28

Brown Syndrome malady

Muscle category

Summaries for Brown Syndrome

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Brown syndrome is an eye disorder characterized by abnormalities in the eye's ability to move. specifically, the ability to look up and in is affected by a problem in the superior oblique muscle/tendon. the condition may be present at birth (congenital) or it may develop following surgery or as a result of inflammation or a problem with development. some cases are constant while other are intermittent. treatment depends upon the cause and severity of the movement disorder. options include close observation, nonsteroidal anti-inflammatory agents like ibuprofen, corticosteroids, and surgery. last updated: 12/5/2011

MalaCards: Brown Syndrome, also known as tendon sheath adherence, superior oblique, is related to brooks wisniewski brown syndrome and brown-sequard syndrome. An important gene associated with Brown Syndrome is PHOX2A (paired-like homeobox 2a). Affiliated tissues include spinal cord, lung and cortex, and related mouse phenotypes are behavior/neurological and respiratory system.

Wikipedia:64 Brown syndrome is a rare form of strabismus characterized by limited elevation of the affected eye. The... more...

Aliases & Classifications for Brown Syndrome

Sources:
43NIH Rare Diseases, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Muscle


Aliases & Descriptions:

brown syndrome 43
tendon sheath adherence, superior oblique 43
superior oblique tendon sheath syndrome 43
brown tendon sheath syndrome 61


Related Diseases for Brown Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Brown Syndrome:



Diseases related to brown syndrome

Clinical Features for Brown Syndrome

Drugs & Therapeutics for Brown Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Brown Syndrome

Anatomical Context for Brown Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Brown Syndrome:

33
Spinal cord, Lung, Cortex, Small intestine, Colon, Endothelial

Animal Models for Brown Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Brown Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.1FBN2, PHOX2A
2MP:00053888.8FBN2, PHOX2A

Publications for Brown Syndrome

Sources:
51PubMed
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Articles related to Brown Syndrome:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
Brown-SAcquard Syndrome; Right HemihA (20914597)
matomyelia.
2
Fine mapping for Weaver syndrome in Brown Swiss cattle and the identification of 41 concordant mutations across NRCAM, PNPLA8 and CTTNBP2. (23527149)
2013
3
Diffusion tensor imaging and tractography in Brown-Sequard syndrome. (23045298)
2012
4
Central Brown-Sequard syndrome caused by hyperextension: an unexpected complication of cervical pedicle screw fixation. (22305154)
2012
5
Transverse myelitis with Brown-SA"quard syndrome after H1N1 immunization. (22836467)
2012
6
A Commentary on 'Four novel C20ORF54 mutations identified in Brown-Vialetto-Van Laere syndrome patients.'. (22786578)
2012
7
Brown-Vialetto-Van Laere syndrome: a riboflavin-unresponsive patient with a novel mutation in the C20orf54 gene. (22633641)
2012
8
Four cases of brown-vialetto-van laere syndrome from Iran: Clinical and electrophysiologic findings. (24250848)
2011
9
Brown-Sequard syndrome revealing intradural thoracic disc herniation. (20589517)
2011
10
Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome. (21752788)
2011
11
Late spontaneous resolution of congenital Brown syndrome. (21168089)
2010
12
Brown-Sequard syndrome after thoracic endovascular aortic repair. (19833642)
2010
13
Brown-SAcquard syndrome due to penetrating injury by an iron fence point. (20010907)
2010
14
Brachial plexus-avulsion causing Brown-Sequard syndrome: a report of three cases. (19092010)
2009
15
Brown syndrome with bifid scleral insertion of the superior oblique. (19496499)
2009
16
Case files of the program in medical toxicology at brown university: amantadine withdrawal and the neuroleptic malignant syndrome. (19415596)
2009
17
Small-caliber gunshot wound with fragment lodged in thoracic foramen in a patient with partial Brown-Sequard syndrome. (18438479)
2008
18
Brown-Sequard syndrome following firearm injury with a bullet lodged in the upper cervical canal. (18541091)
2008
19
Brown-SA"quard syndrome produced by C3-C4 cervical disc herniation: a case report and review of the literature. (18427307)
2008
20
Bilateral Brown syndrome in monozygotic twins. (18258471)
2008
21
Brown-Vialetto-Van Laere syndrome. (18416855)
2008
22
Brown-SAcquard syndrome following stab injury. (16916403)
2006
23
Brown SAcquard syndrome due to cervical pen assault. (16356750)
2006
24
Diagnostics of incomplete Brown-Sequard syndrome caused by meningococcal myelitis. (17125062)
2006
25
Brown-SAcquard syndrome following removal of a cerebrospinal fluid drainage catheter after thoracic aortic surgery. (16551950)
2006
26
Cardiac arrest in a patient with Brown-Vialetto-Van Laere syndrome. (16963409)
2006
27
Brown syndrome associated with morning glory syndrome. (16340505)
2005
28
High-resolution magnetic resonance imaging demonstrates varied anatomic abnormalities in Brown syndrome. (16213393)
2005
29
Cervical spondylosis with thoracic level Brown-SAcquard syndrome. (15519871)
2004
30
A case of Brown-Sequard syndrome with associated Horner's syndrome after blunt injury to the cervical spine. (11696522)
2001
31
A family with autosomal dominant distal arthrogryposis multiplex congenita and brown syndrome. (10617921)
1999
32
High cervical disc herniation and Brown-Sequard syndrome. A case report and review of the literature. (10872367)
1999
33
Multiple sclerosis presenting with a Brown-SAcquard syndrome. (9559998)
1998
34
Brown-Sequard syndrome due to isolated blunt trauma. (9848698)
1998
35
Brown-SAcquard syndrome due to traumatic brachial plexus root avulsion. (9616398)
1997
36
Brown-SAcquard syndrome associated with Horner's syndrome in cervical epidural hematoma. (7716632)
1995
37
Postvaccinial (influenza) disseminated encephalopathy (Brown-Sequard syndrome). (9583968)
1995
38
Acquired Brown syndrome associated with enteropathic arthropathy: a case report. (7912268)
1994
39
Comparison of superior oblique tendon expander to superior oblique tenotomy for the management of superior oblique overaction and Brown syndrome. (1588483)
1992
40
Modified Brown-SAcquard syndrome following coronary artery bypass graft: case report. (1630844)
1992
41
Superior oblique silicone expander for Brown syndrome and superior oblique overaction. (2051286)
1991
42
Brown-SAcquard syndrome in a patient with systemic lupus erythematosus. (2392244)
1990
43
Tenosynovitis of the superior oblique muscle (Brown syndrome) associated with juvenile rheumatoid arthritis. (3981317)
1985
44
Atypical Brown-Sequard syndrome following gunshot wound to the face. (6953180)
1982
45
Weaver syndrome in Brown Swiss cattle: clinical signs & pathology. (4488646)
1973
46
Spinal epidural hematoma and the Brown-SAcquard syndrome. (5165307)
1971
47
Brown-SAcquard syndrome. (5246915)
1968
48
Partial Brown-Sequard syndrome associated with coarctation of the aorta: review of literature and report of a surgically treated case. (13520560)
1958
49
Brown-SAcquard Syndrome at C 2 Level due to Vascular Lesion of Cord. (19991385)
1938
50
(?) Syringomyelia with Brown-SAcquard Syndrome. (19974496)
1910

Genetic Variations for Brown Syndrome

Expression for genes affiliated with Brown Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brown Syndrome

Search GEO for disease gene expression data for Brown Syndrome.

Pathways for genes affiliated with Brown Syndrome

Compounds for genes affiliated with Brown Syndrome

GO Terms for genes affiliated with Brown Syndrome

Products for genes affiliated with Brown Syndrome

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Sources for Brown Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet