MCID: BRW006
MIFTS: 22

Brown Syndrome malady

Rare diseases, Muscle diseases categories
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Summaries for Brown Syndrome

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NIH Rare Diseases:42 Brown syndrome is an eye disorder characterized by abnormalities in the eye's ability to move. specifically, the ability to look up and in is affected by a problem in the superior oblique muscle/tendon. the condition may be present at birth (congenital) or it may develop following surgery or as a result of inflammation or a problem with development. some cases are constant while other are intermittent. treatment depends upon the cause and severity of the movement disorder. options include close observation, nonsteroidal anti-inflammatory agents like ibuprofen, corticosteroids, and surgery. last updated: 12/5/2011

MalaCards based summary: Brown Syndrome, also known as superior oblique tendon sheath syndrome, is related to brooks wisniewski brown syndrome and spastic paraplegia facial cutaneous lesions. An important gene associated with Brown Syndrome is PHOX2A (paired-like homeobox 2a). Affiliated tissues include eye.

Wikipedia:65 Brown syndrome is a rare form of strabismus characterized by limited elevation of the affected eye. The... more...

Aliases & Classifications for Brown Syndrome

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Brown Syndrome, Aliases & Descriptions:

Name: Brown Syndrome 42
Superior Oblique Tendon Sheath Syndrome 42 62
 
Tendon Sheath Adherence, Superior Oblique 42
Brown Tendon Sheath Syndrome 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Muscle diseases


Related Diseases for Brown Syndrome

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Diseases related to Brown Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1brooks wisniewski brown syndrome10.4
2spastic paraplegia facial cutaneous lesions10.2
3cysticercosis10.1
4sinusitis9.9
5systemic scleroderma9.9
6velocardiofacial syndrome9.9
7duane retraction syndrome9.9
8distal arthrogryposis9.9
9fourth cranial nerve palsy9.9
10amblyopia9.9
11arthropathy9.9
12cranial nerve palsy9.9
13psoriasis9.9
14scleroderma9.9
15osteochondroma9.9
16mental retardation9.9

Graphical network of diseases related to Brown Syndrome:



Diseases related to brown syndrome

Symptoms for Brown Syndrome

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Drugs & Therapeutics for Brown Syndrome

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Drug clinical trials:

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Genetic Tests for Brown Syndrome

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Anatomical Context for Brown Syndrome

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MalaCards organs/tissues related to Brown Syndrome:

32
Eye

Animal Models for Brown Syndrome or affiliated genes

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Publications for Brown Syndrome

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Articles related to Brown Syndrome:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Ethmoidal sinus mucocele as a cause of acquired brown syndrome. (25276088)
2014
2
Trochlea surgery for acquired Brown syndrome. (24568984)
2014
3
Clinical progression of untreated bilateral Brown syndrome. (24698613)
2014
4
The results of Brown syndrome surgery with superior oblique split tendon lengthening. (24564724)
2014
5
Fourth cranial nerve palsy and Brown syndrome: two interrelated congenital cranial dysinnervation disorders? (23636931)
2013
6
Amblyopia and sensory features at initial presentation of Brown syndrome: an issue to recognize. (23370414)
2013
7
Sequential presentation of bilateral Brown syndrome. (22525185)
2012
8
Possible association of congenital Brown syndrome with congenital cranial dysinnervation disorders. (23237754)
2012
9
Absence of the fourth cranial nerve in congenital Brown syndrome. (22268674)
2012
10
Congenital unilateral brown syndrome in non-twin siblings. (21766745)
2011
11
Superior oblique tendon expansion with Achilles tendon allograft for treating Brown syndrome. (21665503)
2011
12
Monocular partial/sector occlusion therapy: a procedure to inhibit diplopia in Brown syndrome. (21216206)
2011
13
Late spontaneous resolution of congenital Brown syndrome. (21168089)
2010
14
A case of acquired Brown syndrome after surgical repair of a medial orbital wall fracture. (20157416)
2010
15
Brown syndrome in one pair of dizygotic twins: a case report. (20076806)
2010
16
Late spontaneous resolution of congenital Brown syndrome. (20637665)
2010
17
Spontaneous resolution in patients with congenital Brown syndrome. (19084441)
2009
18
Brown syndrome--operate or observe? (19393508)
2009
19
Brown syndrome with bifid scleral insertion of the superior oblique. (19496499)
2009
20
MR imaging features of acquired Brown syndrome. (19369611)
2009
21
Long-term results of an intraoperative adjustable superior oblique tendon suture spacer using nonabsorbable suture for Brown Syndrome. (18538400)
2008
22
Management of Brown syndrome. (19085429)
2008
23
Bilateral Brown syndrome related to sinusitis. (19020644)
2008
24
Mitochondrial dysfunction in Brooks-Wisniewski-Brown syndrome. (16477654)
2006
25
Surgical outcomes in correction of Brown syndrome. (16768188)
2006
26
Brown syndrome associated with morning glory syndrome. (16340505)
2005
27
Bilateral acquired Brown syndrome in systemic scleroderma. (15838452)
2005
28
Acquired simulated brown syndrome following surgical repair of medial orbital wall fracture. (15929493)
2005
29
Association of Duane retraction syndrome and Brown syndrome. (16121554)
2005
30
Ethmoidal sinus mucocele: an unusual cause of acquired Brown syndrome. (16024873)
2005
31
High-resolution magnetic resonance imaging demonstrates varied anatomic abnormalities in Brown syndrome. (16213393)
2005
32
Brown syndrome associated with velocardiofacial syndrome. (15226737)
2004
33
Acquired brown syndrome secondary to superior oblique muscle cysticercosis. (12690365)
2003
34
Large-segment superior oblique tendon expanders in the management of severe congenital Brown syndrome. (12917615)
2003
35
Familial unilateral Brown syndrome. (12324876)
2002
36
Long-term results of silicone expander for moderate and severe Brown syndrome (Brown syndrome "plus"). (10613574)
1999
37
A family with autosomal dominant distal arthrogryposis multiplex congenita and brown syndrome. (10617921)
1999
38
Magnetic resonance imaging of acquired Brown syndrome in a patient with psoriasis. (10030581)
1999
39
Grave complications after superior oblique tenotomy or tenectomy for Brown syndrome. (10530979)
1997
40
Downgaze restriction after placement of superior oblique tendon spacer for Brown syndrome. (7752031)
1995
41
Acquired Brown syndrome associated with enteropathic arthropathy: a case report. (7912268)
1994
42
Spontaneous consecutive Brown syndrome following superior oblique palsy. (21314514)
1993
43
Natural history of presumed congenital Brown syndrome. (8328936)
1993
44
The surgical treatment of traumatic Brown syndrome. (1432513)
1992
45
Comparison of superior oblique tendon expander to superior oblique tenotomy for the management of superior oblique overaction and Brown syndrome. (1588483)
1992
46
Surgical results in Brown syndrome. (1890575)
1991
47
Bilateral Brown syndrome in three siblings. (1757853)
1991
48
Superior oblique silicone expander for Brown syndrome and superior oblique overaction. (2051286)
1991
49
Brown syndrome associated with contralateral superior oblique palsy: a case report. (1757854)
1991
50
Computed tomography in the evaluation of Brown syndrome of the superior oblique tendon sheath. (3969472)
1985

Variations for Brown Syndrome

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Expression for genes affiliated with Brown Syndrome

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Expression patterns in normal tissues for genes affiliated with Brown Syndrome

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Pathways for genes affiliated with Brown Syndrome

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Compounds for genes affiliated with Brown Syndrome

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GO Terms for genes affiliated with Brown Syndrome

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Products for genes affiliated with Brown Syndrome

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  • Antibodies
  • Proteins
  • Lysates

Sources for Brown Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet