MCID: BRW006
MIFTS: 22

Brown Syndrome malady

Rare diseases, Muscle diseases categories

Summaries for Brown Syndrome

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Sources:
44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Brown syndrome is an eyeĀ disorder characterized by abnormalities in the eye's ability to move. specifically, the ability to look up and inĀ is affected by a problem in the superior oblique muscle/tendon. the condition may be present at birth (congenital) or it may develop following surgery or as a result of inflammation or a problem with development. some cases are constant while other are intermittent.Ā treatment depends upon the cause and severity of the movement disorder. options include close observation, nonsteroidal anti-inflammatory agents like ibuprofen, corticosteroids, and surgery. last updated: 12/5/2011

MalaCards: Brown Syndrome, also known as tendon sheath adherence, superior oblique, is related to brooks wisniewski brown syndrome and spastic paraplegia facial cutaneous lesions. An important gene associated with Brown Syndrome is PHOX2A (paired-like homeobox 2a). Affiliated tissues include eye.

Wikipedia:66 Brown syndrome is a rare form of strabismus characterized by limited elevation of the affected eye. The... more...

Aliases & Classifications for Brown Syndrome

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63UMLS, 44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Muscle diseases


Aliases & Descriptions:

brown syndrome 44
tendon sheath adherence, superior oblique 44
superior oblique tendon sheath syndrome 44
brown tendon sheath syndrome 63


Related Diseases for Brown Syndrome

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of diseases related to Brown Syndrome:



Diseases related to brown syndrome

Symptoms for Brown Syndrome

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Drugs & Therapeutics for Brown Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Brown Syndrome

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Anatomical Context for Brown Syndrome

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Sources:
34MalaCards
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MalaCards organs/tissues related to Brown Syndrome:

34
Eye

Animal Models for Brown Syndrome or affiliated genes

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Publications for Brown Syndrome

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Sources:
53PubMed
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Articles related to Brown Syndrome:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Fourth cranial nerve palsy and Brown syndrome: two interrelated congenital cranial dysinnervation disorders? (23636931)
2013
2
Amblyopia and sensory features at initial presentation of Brown syndrome: an issue to recognize. (23370414)
2013
3
Sequential presentation of bilateral Brown syndrome. (22525185)
2012
4
Possible association of congenital Brown syndrome with congenital cranial dysinnervation disorders. (23237754)
2012
5
Absence of the fourth cranial nerve in congenital Brown syndrome. (22268674)
2012
6
Pseudo-Brown syndrome: a potential ophthalmologic sequela after a transcaruncular-transconjunctival approach for orbital fracture repair. (22632930)
2012
7
Congenital unilateral brown syndrome in non-twin siblings. (21766745)
2011
8
Superior oblique tendon expansion with Achilles tendon allograft for treating Brown syndrome. (21665503)
2011
9
Monocular partial/sector occlusion therapy: a procedure to inhibit diplopia in Brown syndrome. (21216206)
2011
10
Acquired Brown syndrome: report of two cases. (21907127)
2011
11
Late spontaneous resolution of congenital Brown syndrome. (21168089)
2010
12
A case of acquired Brown syndrome after surgical repair of a medial orbital wall fracture. (20157416)
2010
13
Brown syndrome in one pair of dizygotic twins: a case report. (20076806)
2010
14
Late spontaneous resolution of congenital Brown syndrome. (20637665)
2010
15
We are not ready to use palmaris longus tendon as an autogenous expander for Brown syndrome. (20451849)
2010
16
Spontaneous resolution in patients with congenital Brown syndrome. (19084441)
2009
17
Brown syndrome--operate or observe? (19393508)
2009
18
Brown syndrome with bifid scleral insertion of the superior oblique. (19496499)
2009
19
MR imaging features of acquired Brown syndrome. (19369611)
2009
20
Long-term results of an intraoperative adjustable superior oblique tendon suture spacer using nonabsorbable suture for Brown Syndrome. (18538400)
2008
21
Management of Brown syndrome. (19085429)
2008
22
Bilateral Brown syndrome related to sinusitis. (19020644)
2008
23
Mitochondrial dysfunction in Brooks-Wisniewski-Brown syndrome. (16477654)
2006
24
Surgical outcomes in correction of Brown syndrome. (16768188)
2006
25
Brown syndrome associated with morning glory syndrome. (16340505)
2005
26
Bilateral acquired Brown syndrome in systemic scleroderma. (15838452)
2005
27
Acquired simulated brown syndrome following surgical repair of medial orbital wall fracture. (15929493)
2005
28
Association of Duane retraction syndrome and Brown syndrome. (16121554)
2005
29
Ethmoidal sinus mucocele: an unusual cause of acquired Brown syndrome. (16024873)
2005
30
High-resolution magnetic resonance imaging demonstrates varied anatomic abnormalities in Brown syndrome. (16213393)
2005
31
Brown syndrome associated with velocardiofacial syndrome. (15226737)
2004
32
Large-segment superior oblique tendon expanders in the management of severe congenital Brown syndrome. (12917615)
2003
33
Familial unilateral Brown syndrome. (12324876)
2002
34
Extraocular muscle cysticercosis presenting as Brown syndrome. (11292430)
2001
35
Long-term results of silicone expander for moderate and severe Brown syndrome (Brown syndrome "plus"). (10613574)
1999
36
A family with autosomal dominant distal arthrogryposis multiplex congenita and brown syndrome. (10617921)
1999
37
Magnetic resonance imaging of acquired Brown syndrome in a patient with psoriasis. (10030581)
1999
38
Grave complications after superior oblique tenotomy or tenectomy for Brown syndrome. (10530979)
1997
39
Downgaze restriction after placement of superior oblique tendon spacer for Brown syndrome. (7752031)
1995
40
Acquired Brown syndrome associated with enteropathic arthropathy: a case report. (7912268)
1994
41
Spontaneous consecutive Brown syndrome following superior oblique palsy. (21314514)
1993
42
Natural history of presumed congenital Brown syndrome. (8328936)
1993
43
The surgical treatment of traumatic Brown syndrome. (1432513)
1992
44
Comparison of superior oblique tendon expander to superior oblique tenotomy for the management of superior oblique overaction and Brown syndrome. (1588483)
1992
45
Surgical results in Brown syndrome. (1890575)
1991
46
Bilateral Brown syndrome in three siblings. (1757853)
1991
47
Superior oblique silicone expander for Brown syndrome and superior oblique overaction. (2051286)
1991
48
Brown syndrome associated with contralateral superior oblique palsy: a case report. (1757854)
1991
49
Computed tomography in the evaluation of Brown syndrome of the superior oblique tendon sheath. (3969472)
1985
50
Tenosynovitis of the superior oblique muscle (Brown syndrome) associated with juvenile rheumatoid arthritis. (3981317)
1985

Variations for Brown Syndrome

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Expression for genes affiliated with Brown Syndrome

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brown Syndrome

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Pathways for genes affiliated with Brown Syndrome

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Compounds for genes affiliated with Brown Syndrome

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GO Terms for genes affiliated with Brown Syndrome

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Products for genes affiliated with Brown Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brown Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet