MCID: BRW006
MIFTS: 28

Brown Syndrome

Categories: Rare diseases, Muscle diseases

Aliases & Classifications for Brown Syndrome

MalaCards integrated aliases for Brown Syndrome:

Name: Brown Syndrome 53 72 49
Tendon Sheath Adherence, Superior Oblique 49
Superior Oblique Tendon Sheath Syndrome 49
Brown Tendon Sheath Syndrome 69
Brwns 53

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant

Miscellaneous:
noted in early childhood in most patients
some patients have onset in second decade of life


HPO:

31
brown syndrome:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 53 616407
MedGen 39 C0155339
SNOMED-CT via HPO 65 263681008

Summaries for Brown Syndrome

NIH Rare Diseases : 49 Brown syndrome is an eye disorder characterized by abnormalities in the eye's ability to move. Specifically, the ability to look up and in is affected by a problem in the superior oblique muscle/tendon. The condition may be present at birth (congenital) or it may develop following surgery or as a result of inflammation or a problem with development. Some cases are constant while other are intermittent. Treatment depends upon the cause and severity of the movement disorder. Options include close observation, nonsteroidal anti-inflammatory agents like Ibuprofen, corticosteroids, and surgery. Last updated: 12/5/2011

MalaCards based summary : Brown Syndrome, also known as tendon sheath adherence, superior oblique, is related to brooks-wisniewski-brown syndrome and spastic paraplegia facial cutaneous lesions, and has symptoms including smooth pursuit deficiency, pseudoophthalmoplegia and spasm of conjugate gaze. An important gene associated with Brown Syndrome is FBN2 (Fibrillin 2). Affiliated tissues include eye.

OMIM : 53 Brown syndrome, originally described by Brown (1950), is characterized by the inability to elevate the adducted eye actively or passively. There is less elevation deficit with the eye in midposition, and minimal or no deficit in abduction. There can also be divergence on upgaze, downshoot, or widening of the palpebral fissure on adduction, primary hypotropia, and anomalous head posture. Brown syndrome accounts for approximately 2% of strabismus cases. Ten percent of cases are bilateral, and left- and right-sided unilateral cases are equal in frequency. There is no gender predilection (summary by Heidary et al., 2012). (616407)

Wikipedia : 72 Brown\'s syndrome is a rare form of strabismus characterized by limited elevation of the affected eye.... more...

Related Diseases for Brown Syndrome

Graphical network of the top 20 diseases related to Brown Syndrome:



Diseases related to Brown Syndrome

Symptoms & Phenotypes for Brown Syndrome

Symptoms via clinical synopsis from OMIM:

53
HeadAndNeckHead:
chin-up head posture

HeadAndNeckEyes:
limited or absent ability to elevate eye while in adducted (nasal) position


Clinical features from OMIM:

616407

UMLS symptoms related to Brown Syndrome:


smooth pursuit deficiency, pseudoophthalmoplegia, spasm of conjugate gaze

Drugs & Therapeutics for Brown Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420

Search NIH Clinical Center for Brown Syndrome

Genetic Tests for Brown Syndrome

Anatomical Context for Brown Syndrome

MalaCards organs/tissues related to Brown Syndrome:

38
Eye

Publications for Brown Syndrome

Articles related to Brown Syndrome:

(show top 50) (show all 79)
# Title Authors Year
1
Herpes zoster ophthalmicus and strabismus: a unique cause of secondary Brown syndrome. ( 28625469 )
2017
2
Surgical Management of Brown Syndrome. ( 29156074 )
2017
3
Combined Brown syndrome and superior oblique palsy without a trochlear nerve: case report. ( 28841851 )
2017
4
Sequential congenital and acquired presentation of bilateral Brown syndrome. ( 28577917 )
2017
5
Horizontal Deviations in Congenital Brown Syndrome. ( 29257185 )
2017
6
Steroid intra-trochlear injection for the treatment of acquired Brown syndrome secondary to trochleitis. ( 28770346 )
2017
7
Resolution of acquired Brown syndrome with oral steroid therapy. ( 28757707 )
2017
8
Acquired Brown Syndrome Treated With Traction of Superior Oblique Tendon. ( 26854770 )
2016
9
Brown syndrome with severe amblyopia: a case report from Africa. ( 26090014 )
2015
10
Erratum. Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome. ( 26529043 )
2015
11
Considerations on the etiology of congenital Brown syndrome. ( 26163776 )
2015
12
Magnetic resonance imaging in congenital Brown syndrome. ( 25744329 )
2015
13
Three cases of acquired simulated brown syndrome after blowout fracture operations. ( 26015892 )
2015
14
Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome. ( 26397461 )
2015
15
Clinical evolution of bilateral Brown syndrome. ( 25439308 )
2014
16
The results of Brown syndrome surgery with superior oblique split tendon lengthening. ( 24564724 )
2014
17
Ethmoidal sinus mucocele as a cause of acquired brown syndrome. ( 25276088 )
2014
18
Trochlea surgery for acquired Brown syndrome. ( 24568984 )
2014
19
Clinical progression of untreated bilateral Brown syndrome. ( 24698613 )
2014
20
Simulated Brown syndrome in the contralateral eye in superior oblique palsy. ( 22234524 )
2013
21
Fourth cranial nerve palsy and Brown syndrome: two interrelated congenital cranial dysinnervation disorders? ( 23636931 )
2013
22
Amblyopia and sensory features at initial presentation of Brown syndrome: an issue to recognize. ( 23370414 )
2013
23
Possible association of congenital Brown syndrome with congenital cranial dysinnervation disorders. ( 23237754 )
2012
24
Pseudo-Brown syndrome: a potential ophthalmologic sequela after a transcaruncular-transconjunctival approach for orbital fracture repair. ( 22632930 )
2012
25
Sequential presentation of bilateral Brown syndrome. ( 22525185 )
2012
26
Absence of the fourth cranial nerve in congenital Brown syndrome. ( 22268674 )
2012
27
Acquired Brown syndrome: report of two cases. ( 21907127 )
2011
28
Congenital unilateral brown syndrome in non-twin siblings. ( 21766745 )
2011
29
Monocular partial/sector occlusion therapy: a procedure to inhibit diplopia in Brown syndrome. ( 21216206 )
2011
30
Superior oblique tendon expansion with Achilles tendon allograft for treating Brown syndrome. ( 21665503 )
2011
31
Late spontaneous resolution of congenital Brown syndrome. ( 21168089 )
2010
32
We are not ready to use palmaris longus tendon as an autogenous expander for Brown syndrome. ( 20451849 )
2010
33
Brown syndrome in one pair of dizygotic twins: a case report. ( 20076806 )
2010
34
Late spontaneous resolution of congenital Brown syndrome. ( 20637665 )
2010
35
A case of acquired Brown syndrome after surgical repair of a medial orbital wall fracture. ( 20157416 )
2010
36
Spontaneous resolution in patients with congenital Brown syndrome. ( 19084441 )
2009
37
Brown syndrome--operate or observe? ( 19393508 )
2009
38
Brown syndrome with bifid scleral insertion of the superior oblique. ( 19496499 )
2009
39
MR imaging features of acquired Brown syndrome. ( 19369611 )
2009
40
Familial unilateral Brown syndrome. ( 18711279 )
2008
41
Management of Brown syndrome. ( 19085429 )
2008
42
Bilateral Brown syndrome related to sinusitis. ( 19020644 )
2008
43
Superior oblique tendon spacer with application of nonabsorbable adjustable suture for treatment of Brown syndrome. ( 18396080 )
2008
44
Bilateral Brown syndrome in monozygotic twins. ( 18258471 )
2008
45
Long-term results of an intraoperative adjustable superior oblique tendon suture spacer using nonabsorbable suture for Brown Syndrome. ( 18538400 )
2008
46
Osteochondroma of the trochlea presenting as acquired Brown syndrome: a case report. ( 17446102 )
2007
47
Superior oblique posterior tenectomy in patients with Brown syndrome with small deviations in the primary position. ( 16814173 )
2006
48
Mitochondrial dysfunction in Brooks-Wisniewski-Brown syndrome. ( 16477654 )
2006
49
Surgical outcomes in correction of Brown syndrome. ( 16768188 )
2006
50
High-resolution magnetic resonance imaging demonstrates varied anatomic abnormalities in Brown syndrome. ( 16213393 )
2005

Variations for Brown Syndrome

Expression for Brown Syndrome

Search GEO for disease gene expression data for Brown Syndrome.

Pathways for Brown Syndrome

GO Terms for Brown Syndrome

Sources for Brown Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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