MCID: BRW006
MIFTS: 31

Brown Syndrome

Categories: Rare diseases, Muscle diseases

Aliases & Classifications for Brown Syndrome

MalaCards integrated aliases for Brown Syndrome:

Name: Brown Syndrome 50
Tendon Sheath Adherence, Superior Oblique 50
Superior Oblique Tendon Sheath Syndrome 50
Brown Tendon Sheath Syndrome 69

Classifications:



Summaries for Brown Syndrome

NIH Rare Diseases : 50 brown syndrome is an eye disorder characterized by abnormalities in the eye's ability to move. specifically, the ability to look up and in is affected by a problem in the superior oblique muscle/tendon. the condition may be present at birth (congenital) or it may develop following surgery or as a result of inflammation or a problem with development. some cases are constant while other are intermittent. treatment depends upon the cause and severity of the movement disorder. options include close observation, nonsteroidal anti-inflammatory agents like ibuprofen, corticosteroids, and surgery. last updated: 12/5/2011

MalaCards based summary : Brown Syndrome, also known as tendon sheath adherence, superior oblique, is related to brooks-wisniewski-brown syndrome and spastic paraplegia facial cutaneous lesions, and has symptoms including spasm of conjugate gaze, pseudoophthalmoplegia and smooth pursuit deficiency. An important gene associated with Brown Syndrome is FBN2 (Fibrillin 2). The drugs Lopinavir and Guaifenesin have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes.

Wikipedia : 72 Brown\'s syndrome is a rare form of strabismus characterized by limited elevation of the affected eye.... more...

Related Diseases for Brown Syndrome

Diseases related to Brown Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
id Related Disease Score Top Affiliating Genes
1 brooks-wisniewski-brown syndrome 11.9
2 spastic paraplegia facial cutaneous lesions 10.9
3 cysticercosis 9.6
4 amblyopia 9.6
5 rheumatoid arthritis 9.5
6 velocardiofacial syndrome 9.5
7 arthritis 9.5
8 sinusitis 9.5
9 systemic scleroderma 9.5
10 distal arthrogryposis 9.5
11 fourth cranial nerve palsy 9.5
12 duane retraction syndrome 9.5
13 arthropathy 9.5
14 cranial nerve palsy 9.5
15 strabismus 9.5
16 herpes zoster 9.5
17 psoriasis 9.5
18 tenosynovitis 9.5
19 herpes zoster ophthalmicus 9.5
20 morning glory syndrome 9.5
21 osteochondroma 9.5
22 trochleitis 9.5
23 burn goodship syndrome 8.9 FBN2 MRXSBWB PHOX2A

Graphical network of the top 20 diseases related to Brown Syndrome:



Diseases related to Brown Syndrome

Symptoms & Phenotypes for Brown Syndrome

UMLS symptoms related to Brown Syndrome:


spasm of conjugate gaze, pseudoophthalmoplegia, smooth pursuit deficiency

Drugs & Therapeutics for Brown Syndrome

Drugs for Brown Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 360)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lopinavir Approved Phase 4,Phase 1 192725-17-0 92727
2
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
3
Loperamide Approved Phase 4 53179-11-6 3955
4
Methadone Approved Phase 4 76-99-3 4095
5
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
6
Opium Approved, Illicit Phase 4 8008-60-4
7
Phenobarbital Approved Phase 4 50-06-6 4763
8
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
9
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
10
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
11
Enalaprilat Approved Phase 4 76420-72-9 6917719
12
Riluzole Approved, Investigational Phase 4,Phase 2 1744-22-5 5070
13
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
14
Sertraline Approved Phase 4 79617-96-2 68617
15
Rasagiline Approved Phase 4 136236-51-6 3052776
16
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
17
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
18
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
19
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
20
Fluvoxamine Approved, Investigational Phase 4,Phase 3 54739-18-3 3404 5324346
21
Haloperidol Approved Phase 4 52-86-8 3559
22
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
23
Clonidine Approved Phase 4 4205-90-7 2803
24 Piracetam Approved Phase 4 7491-74-9
25
Milnacipran Approved Phase 4,Phase 3 92623-85-3 65833
26
Norepinephrine Approved Phase 4,Phase 3 51-41-2 439260
27
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2 143491-57-0 60877
28
Citalopram Approved Phase 4 59729-33-8 2771
29
Liraglutide Approved Phase 4 204656-20-2 44147092
30
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
31
Fosaprepitant Approved Phase 4 172673-20-0 219090
32
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
33
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
34
Galantamine Approved Phase 4 357-70-0 9651
35
Glutamic Acid Approved, Nutraceutical Phase 4,Phase 2 56-86-0 33032
36 Etiracetam Investigational Phase 4 33996-58-6
37
Substance P Investigational Phase 4 33507-63-0 44359816
38 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Analgesics Phase 4,Phase 3,Phase 2
40 Analgesics, Opioid Phase 4,Phase 2
41 Anticonvulsants Phase 4,Phase 2
42 Antidiarrheals Phase 4
43 Antitussive Agents Phase 4
44 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
45 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
46 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 3,Phase 1
47 Excitatory Amino Acid Antagonists Phase 4,Phase 3,Phase 2
48 Excitatory Amino Acids Phase 4,Phase 3,Phase 2
49 GABA Agents Phase 4
50 GABA Modulators Phase 4

Interventional clinical trials:

(show top 50) (show all 195)

id Name Status NCT ID Phase Drugs
1 Treatment of Neonatal Abstinence Syndrome Completed NCT01723722 Phase 4 Methadone;Diluted Deodorized Tincture of Opium
2 Comparative Effect of Nebivolol vs. Metoprolol on Insulin Sensitivity and Fibrinolytic Balance in Metabolic Syndrome Completed NCT00775671 Phase 4 placebo;Nebivolol;Metoprolol
3 Effect of Sitagliptin and an ACE Inhibitor on Blood Pressure in Metabolic Syndrome Completed NCT00666848 Phase 4 Placebo;Enalapril 5mg;Enalapril 10mg;Sitagliptin
4 Riluzole in Fragile X Syndrome Completed NCT00895752 Phase 4 Riluzole
5 Comparison Between Methadone and Morphine for Neonatal Opiate Withdrawal Completed NCT01804075 Phase 4 Methadone;Morphine
6 Effect of Prolonged PDE-5 Inhibition on Insulin Signaling in Skeletal Muscle. Completed NCT02129725 Phase 4 Sildenafil citrate;Placebo Oral Capsule
7 Effectiveness of Sertraline and Cognitive Behavioral Therapy in Treating Pediatric Obsessive-Compulsive Disorder Completed NCT00382291 Phase 4 Regular Titration;Placebo;Slow Titration
8 The Effect of Rasagiline on Cognition in Parkinson's Disease Completed NCT01382342 Phase 4 Rasagiline;Placebo
9 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
10 Treatment of Obsessive-Compulsive Disorder Completed NCT00000373 Phase 4 olanzapine + fluoxetine;placebo + fluoxetine
11 Comparison of Keppra and Clonidine in the Treatment of Tics Completed NCT00370838 Phase 4 Levetiracetam;Clonidine
12 Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission Completed NCT01018056 Phase 4 D-serine;Riluzole;Placebo
13 Olanzapine in the Treatment of Hair Pulling (Trichotillomania) Completed NCT00182507 Phase 4 Olanzapine
14 Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism Completed NCT01337700 Phase 4 Milnacipran;Placebo
15 Omega-3 Fatty Acids for High Triglycerides in HIV-infected Patients Completed NCT00346697 Phase 4 Omega-3 fatty acid administration;Placebo
16 Antidepressant Response in the Treatment of Depressive Symptoms and Frailty Characteristics in Older Adults Recruiting NCT01973283 Phase 4 Antidepressant Medication
17 Effect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients of South Asian Descent Recruiting NCT02660047 Phase 4 Liraglutide;Liraglutide - Placebo
18 A Rollover Study to Provide Continued Treatment With Eltrombopag Recruiting NCT01957176 Phase 4 ELT
19 Danhong Injection in the Treatment of Acute Ischemic Stroke Recruiting NCT01677208 Phase 4 Danhong injection;placebo
20 Randomized Controlled Trial Comparing a Conservative Management and Laser Surgery Recruiting NCT01220011 Phase 4
21 Effect of Neurokinin-1 Receptor (NK1R) Antagonism on Pruritus in Patients With Sezary Syndrome Terminated NCT01625455 Phase 4 Aprepitant;Placebo
22 Immune Reconstitution of Lopinavir/Ritonavir-Based vs Efavirenz-based HAART in Advanced HIV Disease Terminated NCT00775606 Phase 4 Lopinavir 400 mg/ritonavir 100 mg;Efavirenz
23 Safety Study of Galantamine in Tic Disorders Terminated NCT00226824 Phase 4 galantamine
24 Retraining Walking After Spinal Cord Injury Unknown status NCT00059553 Phase 2, Phase 3
25 Brown Rice Intervention on Metabolic Syndrome (BRIMS) Completed NCT01022411 Phase 2, Phase 3
26 Effects of Flaxseed Supplementation in Metabolic Syndrome Completed NCT02497352 Phase 2, Phase 3
27 Savella in Treatment for Provoked Vestibulodynia Completed NCT01304589 Phase 3 Milnacipran
28 Acamprosate in Youth With Fragile X Syndrome Completed NCT01300923 Phase 3 Acamprosate
29 A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome Completed NCT00658515 Phase 3 Dalcetrapib (RO4607381);Evidence-based medical care for Acute Coronary Syndrome;Placebo
30 The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial Completed NCT01000727 Phase 3 Darapladib 160 mg;Placebo
31 A Phase 3 Study of SME3110 in Pediatric/Adolescent Subjects With Obsessive Compulsive Disorder Completed NCT01933919 Phase 3 fluvoxamine maleate;placebo
32 Safety and Efficacy of Cobicistat-boosted Darunavir in HIV Infected Adults Completed NCT01440569 Phase 3 COBI;DRV;NRTIs
33 Safety and Tolerability of Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01727713 Phase 3 Aripiprazole
34 Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation Completed NCT00004255 Phase 2, Phase 3 cyclophosphamide;fludarabine phosphate;methylprednisolone;tacrolimus
35 Phase 3 Open-Label Study to Evaluate Switching From Optimized Stable Antiretroviral Regimens Containing Darunavir to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) Fixed Dose Combination (FDC) Plus Darunavir (DRV) in Treatment Exp Completed NCT01968551 Phase 3 E/C/F/TAF;DRV;Baseline DRV- containing ARV regimen
36 Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) Versus Placebo in Peri- and Postmenopausal Women Completed NCT00369343 Phase 3 Desvenlafaxine administered as a succinate salt in a sustained-release form (DVS SR);Placebo
37 Controlled Comparison of Two Moxifloxacin Containing Treatment Shortening Regimens in Pulmonary Tuberculosis Completed NCT00864383 Phase 3 Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin
38 Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors Completed NCT00566852 Phase 3 Memantine
39 Reducing Sexual Risk Behaviors and Improving Health for People at a Sexually Transmitted Infection Clinic Completed NCT00947271 Phase 3
40 Effectiveness of an HIV Vaccine in HIV-Negative Adults in North America Who Are at Risk of HIV Infection Completed NCT00002441 Phase 3
41 HIV and STD Prevention for High-Risk, Inner-City, African American Youth Completed NCT00353405 Phase 3
42 Study of Aripiprazole in the Treatment of Serious Behavioral Problems in Children and Adolescents With Autistic Disorder (AD) Completed NCT00365859 Phase 3 Aripiprazole
43 Motivation and Patch Treatment for HIV-positive Smokers Completed NCT00551720 Phase 3
44 Reducing Ethnic Health Disparities: Motivating HIV+ Latinos to Quit Smoking Completed NCT00503230 Phase 3
45 The Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care Versus Placebo and Best Supportive Care in Subjects With Red Blood Cell (RBC) Transfusion-Dependent Anemia and Thrombocytopenia Due to International Prognostic Scoring System (IPSS) Low Recruiting NCT01566695 Phase 3 Oral Azacitidine;Placebo
46 Cardiovascular Inflammation Reduction Trial Recruiting NCT01594333 Phase 3 Methotrexate;Placebo
47 Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome Recruiting NCT02521493 Phase 3 Asparaginase;Asparaginase Erwinia chrysanthemi;Cytarabine;Daunorubicin Hydrochloride;Etoposide;Mitoxantrone Hydrochloride;Thioguanine
48 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
49 Comparison of Aerosol Delivery of Infasurf to Usual Care in Spontaneously Breathing RDS Patients Recruiting NCT03058666 Phase 3 Aerosolized Calfactant
50 Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery Active, not recruiting NCT01372774 Phase 3

Search NIH Clinical Center for Brown Syndrome

Genetic Tests for Brown Syndrome

Anatomical Context for Brown Syndrome

MalaCards organs/tissues related to Brown Syndrome:

39
Eye, Brain, Testes, Myeloid, Spinal Cord, Bone, T Cells

Publications for Brown Syndrome

Articles related to Brown Syndrome:

(show top 50) (show all 77)
id Title Authors Year
1
Combined Brown syndrome and superior oblique palsy without a trochlear nerve: case report. ( 28841851 )
2017
2
Sequential congenital and acquired presentation of bilateral Brown syndrome. ( 28577917 )
2017
3
Resolution of acquired Brown syndrome with oral steroid therapy. ( 28757707 )
2017
4
Steroid intra-trochlear injection for the treatment of acquired Brown syndrome secondary to trochleitis. ( 28770346 )
2017
5
Herpes zoster ophthalmicus and strabismus: a unique cause of secondary Brown syndrome. ( 28625469 )
2017
6
Acquired Brown Syndrome Treated With Traction of Superior Oblique Tendon. ( 26854770 )
2016
7
Considerations on the etiology of congenital Brown syndrome. ( 26163776 )
2015
8
Three cases of acquired simulated brown syndrome after blowout fracture operations. ( 26015892 )
2015
9
Erratum. Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome. ( 26529043 )
2015
10
Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome. ( 26397461 )
2015
11
Magnetic resonance imaging in congenital Brown syndrome. ( 25744329 )
2015
12
Brown syndrome with severe amblyopia: a case report from Africa. ( 26090014 )
2015
13
Clinical progression of untreated bilateral Brown syndrome. ( 24698613 )
2014
14
The results of Brown syndrome surgery with superior oblique split tendon lengthening. ( 24564724 )
2014
15
Ethmoidal sinus mucocele as a cause of acquired brown syndrome. ( 25276088 )
2014
16
Trochlea surgery for acquired Brown syndrome. ( 24568984 )
2014
17
Clinical evolution of bilateral Brown syndrome. ( 25439308 )
2014
18
Amblyopia and sensory features at initial presentation of Brown syndrome: an issue to recognize. ( 23370414 )
2013
19
Simulated Brown syndrome in the contralateral eye in superior oblique palsy. ( 22234524 )
2013
20
Fourth cranial nerve palsy and Brown syndrome: two interrelated congenital cranial dysinnervation disorders? ( 23636931 )
2013
21
Sequential presentation of bilateral Brown syndrome. ( 22525185 )
2012
22
Possible association of congenital Brown syndrome with congenital cranial dysinnervation disorders. ( 23237754 )
2012
23
Absence of the fourth cranial nerve in congenital Brown syndrome. ( 22268674 )
2012
24
Pseudo-Brown syndrome: a potential ophthalmologic sequela after a transcaruncular-transconjunctival approach for orbital fracture repair. ( 22632930 )
2012
25
Superior oblique tendon expansion with Achilles tendon allograft for treating Brown syndrome. ( 21665503 )
2011
26
Monocular partial/sector occlusion therapy: a procedure to inhibit diplopia in Brown syndrome. ( 21216206 )
2011
27
Acquired Brown syndrome: report of two cases. ( 21907127 )
2011
28
Congenital unilateral brown syndrome in non-twin siblings. ( 21766745 )
2011
29
A case of acquired Brown syndrome after surgical repair of a medial orbital wall fracture. ( 20157416 )
2010
30
Brown syndrome in one pair of dizygotic twins: a case report. ( 20076806 )
2010
31
We are not ready to use palmaris longus tendon as an autogenous expander for Brown syndrome. ( 20451849 )
2010
32
Late spontaneous resolution of congenital Brown syndrome. ( 21168089 )
2010
33
Late spontaneous resolution of congenital Brown syndrome. ( 20637665 )
2010
34
Brown syndrome with bifid scleral insertion of the superior oblique. ( 19496499 )
2009
35
Spontaneous resolution in patients with congenital Brown syndrome. ( 19084441 )
2009
36
Brown syndrome--operate or observe? ( 19393508 )
2009
37
MR imaging features of acquired Brown syndrome. ( 19369611 )
2009
38
Bilateral Brown syndrome in monozygotic twins. ( 18258471 )
2008
39
Management of Brown syndrome. ( 19085429 )
2008
40
Long-term results of an intraoperative adjustable superior oblique tendon suture spacer using nonabsorbable suture for Brown Syndrome. ( 18538400 )
2008
41
Superior oblique tendon spacer with application of nonabsorbable adjustable suture for treatment of Brown syndrome. ( 18396080 )
2008
42
Familial unilateral Brown syndrome. ( 18711279 )
2008
43
Bilateral Brown syndrome related to sinusitis. ( 19020644 )
2008
44
Osteochondroma of the trochlea presenting as acquired Brown syndrome: a case report. ( 17446102 )
2007
45
Surgical outcomes in correction of Brown syndrome. ( 16768188 )
2006
46
Mitochondrial dysfunction in Brooks-Wisniewski-Brown syndrome. ( 16477654 )
2006
47
Superior oblique posterior tenectomy in patients with Brown syndrome with small deviations in the primary position. ( 16814173 )
2006
48
Acquired simulated brown syndrome following surgical repair of medial orbital wall fracture. ( 15929493 )
2005
49
High-resolution magnetic resonance imaging demonstrates varied anatomic abnormalities in Brown syndrome. ( 16213393 )
2005
50
Ethmoidal sinus mucocele: an unusual cause of acquired Brown syndrome. ( 16024873 )
2005

Variations for Brown Syndrome

Expression for Brown Syndrome

Search GEO for disease gene expression data for Brown Syndrome.

Pathways for Brown Syndrome

GO Terms for Brown Syndrome

Sources for Brown Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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