MCID: BRW006
MIFTS: 29

Brown Syndrome malady

Categories: Rare diseases, Muscle diseases

Aliases & Classifications for Brown Syndrome

Aliases & Descriptions for Brown Syndrome:

Name: Brown Syndrome 50
Tendon Sheath Adherence, Superior Oblique 50
Superior Oblique Tendon Sheath Syndrome 50
Brown Tendon Sheath Syndrome 69

Classifications:



Summaries for Brown Syndrome

NIH Rare Diseases : 50 brown syndrome is an eye disorder characterized by abnormalities in the eye's ability to move. specifically, the ability to look up and in is affected by a problem in the superior oblique muscle/tendon. the condition may be present at birth (congenital) or it may develop following surgery or as a result of inflammation or a problem with development. some cases are constant while other are intermittent. treatment depends upon the cause and severity of the movement disorder. options include close observation, nonsteroidal anti-inflammatory agents like ibuprofen, corticosteroids, and surgery. last updated: 12/5/2011

MalaCards based summary : Brown Syndrome, also known as tendon sheath adherence, superior oblique, is related to brooks-wisniewski-brown syndrome and spastic paraplegia facial cutaneous lesions, and has symptoms including spasm of conjugate gaze, pseudoophthalmoplegia and smooth pursuit deficiency. An important gene associated with Brown Syndrome is FBN2 (Fibrillin 2). The drugs Buprenorphine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 71 Brown\'s syndrome is a rare form of strabismus characterized by limited elevation of the affected eye.... more...

Related Diseases for Brown Syndrome

Diseases related to Brown Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
id Related Disease Score Top Affiliating Genes
1 brooks-wisniewski-brown syndrome 12.0
2 spastic paraplegia facial cutaneous lesions 10.9
3 cramp-fasciculation syndrome 10.7
4 cysticercosis 9.6
5 amblyopia 9.6
6 c1q nephropathy 9.6 FBN2 MRXSBWB PHOX2A
7 psoriasis 9.5
8 tenosynovitis 9.5
9 rheumatoid arthritis 9.5
10 osteochondroma 9.5
11 velocardiofacial syndrome 9.5
12 arthritis 9.5
13 sinusitis 9.5
14 systemic scleroderma 9.5
15 distal arthrogryposis 9.5
16 fourth cranial nerve palsy 9.5
17 duane retraction syndrome 9.5
18 arthropathy 9.5
19 cranial nerve palsy 9.5

Graphical network of the top 20 diseases related to Brown Syndrome:



Diseases related to Brown Syndrome

Symptoms & Phenotypes for Brown Syndrome

UMLS symptoms related to Brown Syndrome:


spasm of conjugate gaze, pseudoophthalmoplegia, smooth pursuit deficiency

Drugs & Therapeutics for Brown Syndrome

Drugs for Brown Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 449)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
2
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
3
Lopinavir Approved Phase 4,Phase 3,Phase 1 192725-17-0 92727
4
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
5
Loperamide Approved Phase 4 53179-11-6 3955
6
Methadone Approved Phase 4 76-99-3 4095
7
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
8
Opium Approved, Illicit Phase 4 8008-60-4
9
Phenobarbital Approved Phase 4 50-06-6 4763
10
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
11
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
12
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
13
Enalaprilat Approved Phase 4 76420-72-9 6917719
14
Riluzole Approved, Investigational Phase 4,Phase 2 1744-22-5 5070
15
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
16
Sertraline Approved Phase 4 79617-96-2 68617
17
Rasagiline Approved Phase 4 136236-51-6 3052776
18
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
19
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
20
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
21
Fluvoxamine Approved, Investigational Phase 4,Phase 3 54739-18-3 3404 5324346
22
Haloperidol Approved Phase 4 52-86-8 3559
23
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
24
Clonidine Approved Phase 4 4205-90-7 2803
25 Piracetam Approved Phase 4 7491-74-9
26
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
27
Clomipramine Approved, Vet_approved Phase 4 303-49-1 2801
28
Milnacipran Approved Phase 4,Phase 3 92623-85-3 65833
29
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
30
Everolimus Approved Phase 4,Phase 2 159351-69-6 6442177
31
Paclitaxel Approved, Vet_approved Phase 4,Phase 3 33069-62-4 36314
32
Sirolimus Approved, Investigational Phase 4,Phase 2 53123-88-9 5284616 6436030 46835353
33
Abacavir Approved, Investigational Phase 4,Phase 3,Phase 2 136470-78-5 65140 441300
34
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2 143491-57-0 60877
35
Lamivudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 134678-17-4 60825
36
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
37
Tenofovir Approved, Investigational Phase 4,Phase 3,Phase 2 147127-20-6 464205
38
Indinavir Approved Phase 4,Phase 3,Phase 2 150378-17-9 5362440
39
Zidovudine Approved Phase 4,Phase 3,Phase 2,Phase 1 30516-87-1 35370
40
Norepinephrine Approved Phase 4,Phase 3 51-41-2 439260
41
Efavirenz Approved, Investigational Phase 4,Phase 3,Phase 2 154598-52-4 64139
42
Liraglutide Approved Phase 4 204656-20-2
43
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
44
Fosaprepitant Approved Phase 4 172673-20-0 219090
45
Galantamine Approved Phase 4 357-70-0 9651 908828, 9651
46
Clopidogrel Approved, Nutraceutical Phase 4 120202-66-6, 113665-84-2 60606
47
Substance P Investigational Phase 4 33507-63-0 44359816
48 Analgesics Phase 4,Phase 3,Phase 2
49 Analgesics, Opioid Phase 4,Phase 2
50 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 274)
id Name Status NCT ID Phase
1 Buprenorphine and Integrated HIV Care Evaluation Unknown status NCT00124358 Phase 4
2 Treatment of Neonatal Abstinence Syndrome Completed NCT01723722 Phase 4
3 Comparative Effect of Nebivolol vs. Metoprolol on Insulin Sensitivity and Fibrinolytic Balance in Metabolic Syndrome Completed NCT00775671 Phase 4
4 Effect of Sitagliptin and an ACE Inhibitor on Blood Pressure in Metabolic Syndrome Completed NCT00666848 Phase 4
5 Riluzole in Fragile X Syndrome Completed NCT00895752 Phase 4
6 Comparison Between Methadone and Morphine for Neonatal Opiate Withdrawal Completed NCT01804075 Phase 4
7 Effect of Prolonged PDE-5 Inhibition on Insulin Signaling in Skeletal Muscle. Completed NCT02129725 Phase 4
8 Effectiveness of Sertraline and Cognitive Behavioral Therapy in Treating Pediatric Obsessive-Compulsive Disorder Completed NCT00382291 Phase 4
9 The Effect of Rasagiline on Cognition in Parkinson's Disease Completed NCT01382342 Phase 4
10 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4
11 Treatment of Obsessive-Compulsive Disorder Completed NCT00000373 Phase 4
12 Comparison of Keppra and Clonidine in the Treatment of Tics Completed NCT00370838 Phase 4
13 Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission Completed NCT01018056 Phase 4
14 Olanzapine in the Treatment of Hair Pulling (Trichotillomania) Completed NCT00182507 Phase 4
15 Quetiapine Augmentation Versus Clomipramine Augmentation of SSRI for Obsessive-Compulsive Disorder Patients Completed NCT00564564 Phase 4
16 Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism Completed NCT01337700 Phase 4
17 Using Drug Augmentation to Treat Obsessive Compulsive Disorder Patients Who Did Not Respond to Previous Treatment Completed NCT00466609 Phase 4
18 Omega-3 Fatty Acids for High Triglycerides in HIV-infected Patients Completed NCT00346697 Phase 4
19 The Dual Antiplatelet Therapy Study (DAPT Study) Completed NCT00977938 Phase 4
20 Safety and Efficacy Study of Switching From Epzicom to Truvada Completed NCT00724711 Phase 4
21 The Effectiveness of Indinavir Plus Zidovudine Plus Lamivudine in HIV-Infected Patients With No Symptoms of Infection Completed NCT00002179 Phase 4
22 Antidepressant Response in the Treatment of Depressive Symptoms and Frailty Characteristics in Older Adults Recruiting NCT01973283 Phase 4
23 Effect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients of South Asian Descent Recruiting NCT02660047 Phase 4
24 A Rollover Study to Provide Continued Treatment With Eltrombopag Recruiting NCT01957176 Phase 4
25 Danhong Injection in the Treatment of Acute Ischemic Stroke Recruiting NCT01677208 Phase 4
26 Randomized Controlled Trial Comparing a Conservative Management and Laser Surgery Recruiting NCT01220011 Phase 4
27 Effect of Neurokinin-1 Receptor (NK1R) Antagonism on Pruritus in Patients With Sezary Syndrome Terminated NCT01625455 Phase 4
28 Immune Reconstitution of Lopinavir/Ritonavir-Based vs Efavirenz-based HAART in Advanced HIV Disease Terminated NCT00775606 Phase 4
29 Safety Study of Galantamine in Tic Disorders Terminated NCT00226824 Phase 4
30 Retraining Walking After Spinal Cord Injury Unknown status NCT00059553 Phase 2, Phase 3
31 Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors Unknown status NCT00566852 Phase 3
32 Brown Rice Intervention on Metabolic Syndrome (BRIMS) Completed NCT01022411 Phase 2, Phase 3
33 Effects of Flaxseed Supplementation in Metabolic Syndrome Completed NCT02497352 Phase 2, Phase 3
34 Savella in Treatment for Provoked Vestibulodynia Completed NCT01304589 Phase 3
35 Acamprosate in Youth With Fragile X Syndrome Completed NCT01300923 Phase 3
36 A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome Completed NCT00658515 Phase 3
37 The Stabilization Of pLaques usIng Darapladib-Thrombolysis In Myocardial Infarction 52 Trial Completed NCT01000727 Phase 3
38 A Phase 3 Study of SME3110 in Pediatric/Adolescent Subjects With Obsessive Compulsive Disorder Completed NCT01933919 Phase 3
39 Safety and Efficacy of Cobicistat-boosted Darunavir in HIV Infected Adults Completed NCT01440569 Phase 3
40 Safety and Tolerability of Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT01727713 Phase 3
41 Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation Completed NCT00004255 Phase 2, Phase 3
42 Phase 3 Open-Label Study to Evaluate Switching From Optimized Stable Antiretroviral Regimens Containing Darunavir to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) Fixed Dose Combination (FDC) Plus Darunavir (DRV) in Treatment Exp Completed NCT01968551 Phase 3
43 Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) Versus Placebo in Peri- and Postmenopausal Women Completed NCT00369343 Phase 3
44 Controlled Comparison of Two Moxifloxacin Containing Treatment Shortening Regimens in Pulmonary Tuberculosis Completed NCT00864383 Phase 3
45 Reducing Sexual Risk Behaviors and Improving Health for People at a Sexually Transmitted Infection Clinic Completed NCT00947271 Phase 3
46 Effectiveness of an HIV Vaccine in HIV-Negative Adults in North America Who Are at Risk of HIV Infection Completed NCT00002441 Phase 3
47 HIV and STD Prevention for High-Risk, Inner-City, African American Youth Completed NCT00353405 Phase 3
48 Study of Aripiprazole in the Treatment of Serious Behavioral Problems in Children and Adolescents With Autistic Disorder (AD) Completed NCT00365859 Phase 3
49 Motivation and Patch Treatment for HIV-positive Smokers Completed NCT00551720 Phase 3
50 Reducing Ethnic Health Disparities: Motivating HIV+ Latinos to Quit Smoking Completed NCT00503230 Phase 3

Search NIH Clinical Center for Brown Syndrome

Genetic Tests for Brown Syndrome

Anatomical Context for Brown Syndrome

MalaCards organs/tissues related to Brown Syndrome:

39
Eye

Publications for Brown Syndrome

Articles related to Brown Syndrome:

(show top 50) (show all 72)
id Title Authors Year
1
Acquired Brown Syndrome Treated With Traction of Superior Oblique Tendon. ( 26854770 )
2016
2
Considerations on the etiology of congenital Brown syndrome. ( 26163776 )
2015
3
Erratum. Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome. ( 26529043 )
2015
4
Magnetic resonance imaging in congenital Brown syndrome. ( 25744329 )
2015
5
Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome. ( 26397461 )
2015
6
Brown syndrome with severe amblyopia: a case report from Africa. ( 26090014 )
2015
7
Three cases of acquired simulated brown syndrome after blowout fracture operations. ( 26015892 )
2015
8
Clinical progression of untreated bilateral Brown syndrome. ( 24698613 )
2014
9
Clinical evolution of bilateral Brown syndrome. ( 25439308 )
2014
10
Ethmoidal sinus mucocele as a cause of acquired brown syndrome. ( 25276088 )
2014
11
Trochlea surgery for acquired Brown syndrome. ( 24568984 )
2014
12
The results of Brown syndrome surgery with superior oblique split tendon lengthening. ( 24564724 )
2014
13
Amblyopia and sensory features at initial presentation of Brown syndrome: an issue to recognize. ( 23370414 )
2013
14
Simulated Brown syndrome in the contralateral eye in superior oblique palsy. ( 22234524 )
2013
15
Fourth cranial nerve palsy and Brown syndrome: two interrelated congenital cranial dysinnervation disorders? ( 23636931 )
2013
16
Sequential presentation of bilateral Brown syndrome. ( 22525185 )
2012
17
Absence of the fourth cranial nerve in congenital Brown syndrome. ( 22268674 )
2012
18
Pseudo-Brown syndrome: a potential ophthalmologic sequela after a transcaruncular-transconjunctival approach for orbital fracture repair. ( 22632930 )
2012
19
Possible association of congenital Brown syndrome with congenital cranial dysinnervation disorders. ( 23237754 )
2012
20
Acquired Brown syndrome: report of two cases. ( 21907127 )
2011
21
Congenital unilateral brown syndrome in non-twin siblings. ( 21766745 )
2011
22
Superior oblique tendon expansion with Achilles tendon allograft for treating Brown syndrome. ( 21665503 )
2011
23
Monocular partial/sector occlusion therapy: a procedure to inhibit diplopia in Brown syndrome. ( 21216206 )
2011
24
Brown syndrome in one pair of dizygotic twins: a case report. ( 20076806 )
2010
25
Late spontaneous resolution of congenital Brown syndrome. ( 21168089 )
2010
26
Late spontaneous resolution of congenital Brown syndrome. ( 20637665 )
2010
27
A case of acquired Brown syndrome after surgical repair of a medial orbital wall fracture. ( 20157416 )
2010
28
We are not ready to use palmaris longus tendon as an autogenous expander for Brown syndrome. ( 20451849 )
2010
29
Brown syndrome with bifid scleral insertion of the superior oblique. ( 19496499 )
2009
30
Spontaneous resolution in patients with congenital Brown syndrome. ( 19084441 )
2009
31
MR imaging features of acquired Brown syndrome. ( 19369611 )
2009
32
Brown syndrome--operate or observe? ( 19393508 )
2009
33
Familial unilateral Brown syndrome. ( 18711279 )
2008
34
Superior oblique tendon spacer with application of nonabsorbable adjustable suture for treatment of Brown syndrome. ( 18396080 )
2008
35
Management of Brown syndrome. ( 19085429 )
2008
36
Bilateral Brown syndrome in monozygotic twins. ( 18258471 )
2008
37
Bilateral Brown syndrome related to sinusitis. ( 19020644 )
2008
38
Long-term results of an intraoperative adjustable superior oblique tendon suture spacer using nonabsorbable suture for Brown Syndrome. ( 18538400 )
2008
39
Osteochondroma of the trochlea presenting as acquired Brown syndrome: a case report. ( 17446102 )
2007
40
Surgical outcomes in correction of Brown syndrome. ( 16768188 )
2006
41
Superior oblique posterior tenectomy in patients with Brown syndrome with small deviations in the primary position. ( 16814173 )
2006
42
Mitochondrial dysfunction in Brooks-Wisniewski-Brown syndrome. ( 16477654 )
2006
43
Acquired simulated brown syndrome following surgical repair of medial orbital wall fracture. ( 15929493 )
2005
44
Bilateral acquired Brown syndrome in systemic scleroderma. ( 15838452 )
2005
45
Association of Duane retraction syndrome and Brown syndrome. ( 16121554 )
2005
46
Brown syndrome associated with morning glory syndrome. ( 16340505 )
2005
47
Ethmoidal sinus mucocele: an unusual cause of acquired Brown syndrome. ( 16024873 )
2005
48
High-resolution magnetic resonance imaging demonstrates varied anatomic abnormalities in Brown syndrome. ( 16213393 )
2005
49
Brown syndrome associated with velocardiofacial syndrome. ( 15226737 )
2004
50
Large-segment superior oblique tendon expanders in the management of severe congenital Brown syndrome. ( 12917615 )
2003

Variations for Brown Syndrome

Expression for Brown Syndrome

Search GEO for disease gene expression data for Brown Syndrome.

Pathways for Brown Syndrome

GO Terms for Brown Syndrome

Sources for Brown Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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