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MCID: BRC012
MIFTS: 63

Brucellosis malady

Infectious diseases category
7 symptoms, 54 genes, 13 tissues, 156 related diseases, clinical trials.

Summaries for Brucellosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that is caused by the bacteria of the genus brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. the disease has symptom fever, has symptom sweat, has symptom headache, has symptom back pain, has symptom physical weakness, has symptom joint pain and has symptom fatigue.

MalaCards: Brucellosis, also known as undulant fever, is related to tuberculosis and hepatitis, and has symptoms including fatigue, joint pain and physical weakness. An important gene associated with Brucellosis is SAA1 (serum amyloid A1), and among its related pathways are Primary immunodeficiency and C-MYB transcription factor network. The compounds alpha-naphthyl butyrate and colchicine have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and t cells, and related mouse phenotypes are hematopoietic system and immune system.

CDC:3 Brucellosis is an infectious disease caused by bacteria.

Wikipedia:63 Brucellosis, also called Bang\'s disease, Crimean fever, Gibraltar fever, Malta fever, Maltese fever,... more...

Aliases & Classifications for Brucellosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
ICD10: 26 25


Aliases & Descriptions:

brucellosis 8 42 10 44 48 60
undulant fever 8 42
gibraltar fever 42
maltese fever 8
cyprus fever 42
malta fever 42
rock fever 42


External Ids:

Disease Ontology8 DOID:11077
ICD9CM27 023.9, 023
NCIt39 C84602
MESH via Orphanet35 D002006
SNOMED-CT via Orphanet57 75702008
ICD10 via Orphanet26 A23.0, A23.1, A23.2 A23.3, A23.8, A23.9, more
UMLS via Orphanet61 C0006309

Related Diseases for Brucellosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Brucellosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.5BLZF1, SLC11A1, ADA, LYZ
2hepatitis30.3ANPEP
3arthritis30.1SAA1, PSMB9, MEFV, ANPEP, TAP2, FCGR2A
4meningitis29.9LYZ, ADA, FCGR2A
5hepatitis c29.7TAP2
6vasculitis29.7MEFV, BLZF1, CD14
7acute leukemia29.7ANPEP, BLZF1, CD14
8deficiency anemia29.7SAA1, FCGR2A, SLC11A1
9leukemia29.7PSMB8, ANPEP, BLZF1, CD14, TAP1, TAP2
10brucella melitensis brucellosis10.4
11brucella abortus brucellosis10.4
12pancytopenia10.4
13leptospirosis10.3
14orchitis10.3
15q fever10.3
16brucella canis brucellosis10.3
17epididymo-orchitis10.3
18brucella suis brucellosis10.3
19epidural abscess10.2
20thrombocytopenia10.2
21endocarditis10.2
22hemolytic anemia10.2
23splenic abscess10.1
24cervicitis10.1
25purpura10.1
26tick-borne relapsing fever10.1
27relapsing fever10.1
28rhinotracheitis10.1
29autoimmune hemolytic anemia10.1
30extrapulmonary tuberculosis10.1
31toxoplasmosis10.1
32crohn's disease10.0LYZ
33ulcerative colitis10.0LYZ
34celiac disease10.0MICA
35familial mediterranean fever10.0MEFV, SAA1
36alzheimer's disease10.0BLZF1
37intestinal tuberculosis10.0PSMB9
38myelitis10.0
39thrombotic thrombocytopenic purpura10.0
40capillary leak syndrome10.0
41cholestasis10.0
42glomerulonephritis10.0
43infective endocarditis10.0
44myositis10.0
45panniculitis10.0
46pericardial effusion10.0
47polyneuropathy10.0
48tularemia10.0
49amyloidosis10.0SAA1, MEFV, LYZ
50diabetes mellitus10.0TAP1, CD14

Graphical network of the top 20 diseases related to Brucellosis:



Diseases related to brucellosis

Clinical Features for Brucellosis

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 7)
  • fatigue
  • joint pain
  • physical weakness
  • back pain
  • headache
  • sweat
  • fever

Drugs & Therapeutics for Brucellosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Brucellosis

Drug clinical trials:

Search ClinicalTrials for Brucellosis

Search NIH Clinical Center for Brucellosis

Search CenterWatch for Brucellosis

Genetic Tests for Brucellosis

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Anatomical Context for Brucellosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Brucellosis:

32
Testes, Liver, T cells, Bone, Bone marrow, Skin, Breast, Prostate, Testis, Monocytes, Pons, Spinal cord, Whole blood

Animal Models for Brucellosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Brucellosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
hematopoietic system phenotype
MP:00053979.8PSMB9, MEFV, ANPEP, TAP1, TAP2, FCGR2A
2
immune system phenotype
MP:00053879.4ADA, PSMB8, PSMB9, MEFV, ANPEP, CD14

Publications for Brucellosis

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Sources:
50PubMed
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Articles related to Brucellosis:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
Brucella melitensis T Cell Epitope Recognition in Humans with Brucellosis in Peru. (24126518)
2014
2
Antibiotic susceptibility and treatment of brucellosis. (22812615)
2013
3
A study on seroprevalence of caprine brucellosis under three livestock production systems in southern and central Ethiopia. (22961233)
2013
4
Relationship between I^-interferon gene polymorphisms and susceptibility to brucellosis infection. (24033468)
2013
5
In vitro antimicrobial susceptibility of Brucella melitensis isolates from sheep in an area endemic for human brucellosis in Turkey. (23545462)
2013
6
Determination of the Accuracy and Optimal Cut-off Point for ELISA Test in Diagnosis of Human Brucellosis in Iran. (24338140)
2013
7
Induction of protective immunity against brucellosis in mice by vaccination with a combination of naloxone, alum, and heat-killed Brucella melitensis 16 M. (22727892)
2013
8
The Russian experience in brucellosis veterinary public health. (23837380)
2013
9
Feral swine brucellosis in the United States and prospective genomic techniques for disease epidemiology. (23548760)
2013
10
Amplicon DNA melting analysis for the simultaneous detection of Brucella spp and Mycobacterium tuberculosis complex. Potential use in rapid differential diagnosis between extrapulmonary tuberculosis and focal complications of brucellosis. (23520501)
2013
11
A serological survey of brucellosis in wild ungulate species from five game parks in Zimbabwe. (24396917)
2013
12
Isolation of a field strain of Brucella abortus from RB51-vaccinated- and brucellosis-seronegative bovine yearlings that calved normally. (22956439)
2013
13
Diagnostic value of serum concentrations of high-mobility group-box protein 1 and soluble hemoglobin scavenger receptor in brucellosis. (23278480)
2013
14
Human brucellosis in the People's Republic of China during 2005-2010. (23462301)
2013
15
Tricky brucellosis. (23709547)
2013
16
Bone marrow biopsy findings in brucellosis patients with hematologic abnormalities. (22884045)
2012
17
An uncommon case of acute brucellosis presenting with severe thrombocytopenia. (23207127)
2012
18
Antibiotics for treating human brucellosis. (23076931)
2012
19
Comparison of conventional and non-conventional techniques for the diagnosis of bovine brucellosis in Sudan. (22201013)
2012
20
Pathophysiology of the rhesus macaque model for inhalational brucellosis. (22064715)
2012
21
Cervical spinal brucellosis with epidural abscess causing neurologic deficit with negative serologic tests. (22381278)
2012
22
Fatal case of brucellosis misdiagnosed in early stages of Brucella suis infection in a 46-year-old patient with Marfan syndrome. (22495564)
2012
23
Comparison of four commercial IgM and IgG ELISA kits for diagnosing brucellosis. (21835974)
2011
24
Expression, purification, and improved antigenic specificity of a truncated recombinant bp26 protein of Brucella melitensis M5-90: a potential antigen for differential serodiagnosis of brucellosis in sheep and goats. (21446957)
2011
25
A case of systemic brucellosis with spondylodiscitis mimicking postoperative spondylodiscitis after lumbar disc surgery. (20826876)
2011
26
Seroprevalence and associated risk factors of bovine brucellosis in Addis Ababa dairy farms. (21331496)
2011
27
An analysis of children with brucellosis associated with isolated thrombocytopenia. (20829271)
2011
28
A network control theory approach to modeling and optimal control of zoonoses: case study of brucellosis transmission in sub-Saharan Africa. (22022621)
2011
29
Quantifying risk factors for human brucellosis in rural northern Tanzania. (20376363)
2010
30
Superior mesenteric artery syndrome secondary to brucellosis - A case report. (23133263)
2010
31
Brucellosis in northern Australia. (20889883)
2010
32
Epidemiological characteristics of brucellosis in Serbia, 1980-2008. (20718087)
2010
33
Seroprevalence of brucellosis in animals and human populations in the western mountains region in Libya, December 2006-January 2008. (20684813)
2010
34
Epidemiological and public health aspects of brucellosis in the Republic of Macedonia. (20703182)
2010
35
Epidemiological study of Brucellosis in cattle, immunized with Brucella abortus RB51 vaccine in endemic zones. (20362623)
2010
36
Mapping brucellosis risk in communities in the Republic of Armenia. (21080325)
2010
37
Comparison of the efficacy of gentamicin for 5 days plus doxycycline for 8 weeks versus streptomycin for 2 weeks plus doxycycline for 45 days in the treatment of human brucellosis: a randomized clinical trial. (20215128)
2010
38
Immunoglobulin profiles in acute Brucellosis experimentally induced by Brucella canis in BALB/c mice. (20420532)
2010
39
Immunopotentiation of live brucellosis vaccine by adjuvants. (20362624)
2010
40
Integrated regional bioengagement framework to combat brucellosis. (20703192)
2010
41
Brucellosis triggering hemolytic anemia in glucose-6-phosphate dehydrogenase deficiency. (19494543)
2009
42
Brucellosis presenting as a spinal epidural abscess in a 41-year-old farmer: a case report. (19830004)
2009
43
Association of susceptibility to brucellosis and interleukin-4 promoter polymorphism. (17148075)
2006
44
Seroprevalence of brucellosis, tularemia, and yersiniosis in wild boars (Sus scrofa) from north-eastern Germany. (16364020)
2005
45
Other bacterial diseases as a potential consequence of bioterrorism: Q fever, brucellosis, glanders, and melioidosis. (12833721)
2003
46
Diagnostic usefulness of antibodies against ribosome recycling factor from Brucella melitensis in human or canine brucellosis. (11874879)
2002
47
Antigen-specific activation and proliferation of CD4+ and CD8+ T lymphocytes from brucellosis patients. (12174793)
2002
48
Brucellosis with acute acalculous cholecystitis. (11099103)
2000
49
Cloning of a Brucella melitensis group 3 antigen gene encoding Omp28, a protein recognized by the humoral immune response during human brucellosis. (8698471)
1996
50
Letter: Acute brucellosis presenting as epididymo-orchitis. (4210009)
1974

Genetic Variations for Brucellosis

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Expression for genes affiliated with Brucellosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brucellosis

Search GEO for disease gene expression data for Brucellosis.

Pathways for genes affiliated with Brucellosis

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29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome
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Pathways related to Brucellosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Primary immunodeficiency29
10.3ADA, TAP1
2
C-MYB transcription factor network37
10.2LYZ, ADA, ANPEP
3
Immune response Antigen presentation by MHC class I12
10.2PSMB8, PSMB9, TAP1, TAP2
4
Antigen processing: Ubiquitination & Proteasome degradation53
Hide members
10.2TAP2, TAP1, PSMB9, PSMB8
5
Phagosome29
10.2TAP2, FCGR2A, TAP1, CD14
6
Disease53
10.1SAA1, PSMB8, PSMB9, SLC11A1, LYZ
7
Immune System53
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9.9SAA1, TAP2, TAP1, CD14, MICA, MEFV

Compounds for genes affiliated with Brucellosis

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Sources:
44Novoseek, 59Tocris Bioscience, 2BitterDB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Brucellosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alpha-naphthyl butyrate4410.5CD14, ANPEP
2colchicine59 44 2 28 1114.3ANPEP, MEFV, SAA1
3glutamine4410.2ADA, FCGR2A, TAP2, TAP1, CD14, BLZF1
4sucrose44 11 2412.2ANPEP, BLZF1, CD14, LYZ
5alanine4410.1SAA1, ANPEP, BLZF1, CD14, TAP1, TAP2
6arginine4410.1SAA1, ANPEP, BLZF1, CD14, FCGR2A, ADA
7atp44 2811.1ANPEP, BLZF1, CD14, TAP1, TAP2, FCGR2A
8oligonucleotide4410.1FCGR2A, TAP2, TAP1, CD14, ANPEP
9tuberculin4410.0ADA, CD14
10cholesterol44 28 11 2413.0SAA1, ANPEP, BLZF1, CD14, FCGR2A

GO Terms for genes affiliated with Brucellosis

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16Gene Ontology
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Cellular components related to Brucellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:04282510.3TAP1, TAP2
2spermatoproteasome complexGO:199011110.2PSMB8, PSMB9
3cell surfaceGO:00998610.1MICA, CD14, ADA, SYNJ2BP
4proteasome core complexGO:00583910.0PSMB9, PSMB8

Biological processes related to Brucellosis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.5TAP2, TAP1
2intracellular transport of viral proteins in host cellGO:01906010.5TAP1, TAP2
3negative regulation of inflammatory responseGO:05072810.4SAA1, MEFV, ADA
4peptide transportGO:01583310.4TAP1, TAP2
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.4PSMB9, TAP2, TAP1, PSMB8
6antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259010.4PSMB8, TAP1, TAP2, PSMB9
7antigen processing and presentation of peptide antigen via MHC class IGO:00247410.4PSMB8, PSMB9, TAP1, TAP2
8antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.4TAP2, TAP1
9cytolysisGO:01983510.3MICA, LYZ
10inflammatory responseGO:00695410.2SLC11A1, LYZ, CD14, MEFV
11defense response to bacteriumGO:04274210.1LYZ, SLC11A1, MICA
12modulation by virus of host morphology or physiologyGO:0190489.8MICA, ANPEP, PSMB8, PSMB9

Molecular functions related to Brucellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide transporter activityGO:01519710.4TAP2, TAP1
2tapasin bindingGO:04698010.4TAP2, TAP1
3oligopeptide-transporting ATPase activityGO:01542110.3TAP1, TAP2
4MHC class I protein bindingGO:04228810.3TAP2, TAP1
5TAP1 bindingGO:04697810.2TAP1, TAP2
6TAP2 bindingGO:04697910.0TAP2, TAP1

Products for genes affiliated with Brucellosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brucellosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet
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