MCID: BRC012
MIFTS: 53

Brucellosis malady

Rare diseases, Infectious diseases categories

Summaries for Brucellosis

About this section


NIH Rare Diseases:41 Brucellosis is a bacterial infection that spreads from animals to people via unpasteurized dairy products or by exposure to contaminated animal products or infected animals. animals that are most commonly infected include sheep, cattle, goats, pigs, and dogs. brucellosis can cause of range of signs and symptoms, some of which may persist or recur. initial symptoms may include fever, sweats, malaise, anorexia, headache, fatigue, and/or pain in the muscles, joints, and/or back. symptoms that may persist or recur include fevers, arthritis, swelling of the testicle and scrotum, swelling of the heart (endocarditis), neurologic symptoms (in up to 5% of cases), chronic fatigue, depression, and/or swelling of the liver or spleen. people who are in jobs or settings that increase exposure to the bacteria are at increased risk for infection. antibiotics are used to treat brucellosis. recovery may take a few weeks to several months, and relapses are common. death from brucellosis is rare, occurring in no more than 2% of cases. last updated: 12/12/2014

MalaCards based summary: Brucellosis, also known as undulant fever, is related to vasculitis and arthritis, and has symptoms including fever, sweat and headache. An important gene associated with Brucellosis is MEFV (Mediterranean fever), and among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Presenilin-Mediated Signaling. The compounds colchicine and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and spleen, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:9 A primary bacterial infectious disease that is caused by the bacteria of the genus brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. the disease has symptom fever, has symptom sweat, has symptom headache, has symptom back pain, has symptom physical weakness, has symptom joint pain and has symptom fatigue.

Wikipedia:63 Brucellosis, Bang\'s disease, Crimean fever, Gibraltar fever, Malta fever, Maltese fever, Mediterranean... more...

Aliases & Classifications for Brucellosis

About this section
Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 3CDC, 60UMLS, 27ICD9CM, 55SNOMED-CT, 38NCIt, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Brucellosis, Aliases & Descriptions:

Name: Brucellosis 9 41 11 43 47 3 60
Undulant Fever 9 41 3
Gibraltar Fever 41
Maltese Fever 9
 
Cyprus Fever 41
Malta Fever 41
Rock Fever 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


External Ids:

Disease Ontology9 DOID:11077
ICD9CM27 023, 023.9
NCIt38 C84602
Orphanet47 1304
MESH via Orphanet34 D002006
ICD10 via Orphanet26 A23.0, A23.1, A23.2 A23.3, A23.8, A23.9, more
UMLS via Orphanet61 C0006309

Related Diseases for Brucellosis

About this section

Graphical network of the top 20 diseases related to Brucellosis:



Diseases related to brucellosis

Symptoms for Brucellosis

About this section

Symptoms:

 9 (show all 7)
  • fever
  • sweat
  • headache
  • back pain
  • physical weakness
  • joint pain
  • fatigue

Drugs & Therapeutics for Brucellosis

About this section

Drug clinical trials:

Search ClinicalTrials for Brucellosis

Search NIH Clinical Center for Brucellosis

Genetic Tests for Brucellosis

About this section

Anatomical Context for Brucellosis

About this section

MalaCards organs/tissues related to Brucellosis:

31
Testes, Liver, Spleen, Heart, Bone marrow, Bone, T cells, Skin, Whole blood, Spinal cord, Breast, Prostate, Testis, Endothelial, Pons, Neutrophil

Animal Models for Brucellosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Brucellosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.2PSMB9, PSMB8, MEFV, CD14, SLC11A1, ADA
2MP:00053976.9SLC11A1, CD14, MEFV, PSMB8, PSMB9, ADA

Publications for Brucellosis

About this section

Articles related to Brucellosis:

(show top 50)    (show all 620)
idTitleAuthorsYear
1
Seroprevalence and risk factors of Brucellosis in small ruminants slaughtered at Debre Ziet and Modjo export abattoirs, Ethiopia. (25881526)
2015
2
Transmission dynamics and control for a brucellosis model in Hinggan League of Inner Mongolia, China. (25347802)
2014
3
Acute brucellosis with typical hemophagocytic lymphohistiocytosis accompanying elevated tumor markers. (25305773)
2014
4
Mean platelet volume in brucellosis: correlation between brucella standard serum agglutination test results, platelet count, and C-reactive protein. (25834485)
2014
5
EVALUATION OF THE SENSITIVITY AND SPECIFICITY OF AN ENZYME-LINKED IMMUNOSORBENT ASSAY FOR DIAGNOSING BRUCELLOSIS IN AFRICAN BUFFALO (SYNCERUS CAFFER). (25397998)
2014
6
Herd-level risk factors for Campylobacter fetus infection, Brucella seropositivity and within-herd seroprevalence of brucellosis in cattle in northern Nigeria. (23830113)
2013
7
Bayesian estimation of true prevalence, sensitivity and specificity of indirect ELISA, Rose Bengal Test and Slow Agglutination Test for the diagnosis of brucellosis in sheep and goats in Bangladesh. (23276401)
2013
8
Prevalence and risk factors for brucellosis in goats in areas of Mexico with and without brucellosis control campaign. (23420068)
2013
9
Human brucellosis, a heterogeneously distributed, delayed, and misdiagnosed disease in china. (23175566)
2013
10
New developments in the immunodiagnosis of brucellosis in livestock and wildlife. (23837374)
2013
11
Time series analysis of human and bovine brucellosis in South Korea from 2005 to 2010. (23276400)
2013
12
Severe persistent thrombocytopenia as a sole manifestation of brucellosis. (22544672)
2013
13
Host-Brucella interactions and the Brucella genome as tools for subunit antigen discovery and immunization against brucellosis. (23720712)
2013
14
Antibiotic susceptibility and treatment of brucellosis. (22812615)
2013
15
Two-stage PCR assay for detection of human brucellosis in endemic areas. (23517532)
2013
16
Risk factors associated with brucellosis seropositivity among cattle in the central savannah-forest area of Ivory Coast. (22704904)
2012
17
Laboratory-acquired brucellosis in Turkey. (22365915)
2012
18
Epidemiological and clinical aspects of human brucellosis in eastern Anatolia. (23123390)
2012
19
Estimation of sensitivity and specificity of five serological tests for the diagnosis of porcine brucellosis. (22153032)
2012
20
Brucellosis manifesting as chronic inflammatory demyelinating polyneuropathy. (22728867)
2012
21
Outcomes of treatment in 50 cases with spinal brucellosis in Babol, Northern Iran. (23000864)
2012
22
Application of the microagglutination test for serologic diagnosis of human brucellosis. (24159482)
2012
23
Brucellosis-induced avascular necrosis of the hip in a middle-aged person. (23641397)
2012
24
Osteoarticular manifestations of brucellosis. (22937686)
2012
25
Preliminary study of an immunochromatography test for serological diagnosis of canine brucellosis. (23279541)
2012
26
Brucellosis laboratory tests in Syria: what are their diagnostic efficacies in different clinical manifestations? (22706192)
2012
27
Assessment of performance of selected serological tests for diagnosing brucellosis in pigs. (22445082)
2012
28
Decreasing prevalence of brucellosis in red deer through efforts to control disease in livestock. (21676351)
2011
29
Seroprevalence of Brucellosis among high risk individuals in Guilan, Iran. (22973333)
2011
30
Seroprevalance of brucellosis among suspected cases in Malaysia. (21874749)
2011
31
Hepatic granulomas associated with brucellosis: Hepatic granulomas and brucellosis. (22087106)
2011
32
Lymphocyte activation test for diagnosis of seronegative brucellosis in humans. (22234109)
2011
33
Brucellosis of the European brown hare (Lepus europaeus). (21511271)
2011
34
Pediatric brucellosis: an (almost) forgotten disease. (22125040)
2011
35
Quantifying risk factors for human brucellosis in rural northern Tanzania. (20376363)
2010
36
Superior mesenteric artery syndrome secondary to brucellosis - A case report. (23133263)
2010
37
Brucellosis in northern Australia. (20889883)
2010
38
Ovine and Caprine Brucellosis (Brucella melitensis) in Aborted Animals in Jordanian Sheep and Goat Flocks. (21052561)
2010
39
Gaps in brucellosis eradication campaign in sheep and goats in Republic of Macedonia: lessons learned. (20718089)
2010
40
Prevalence of brucellosis and infectious bovine rhinotracheitis in organized dairy farms in India. (19644761)
2010
41
Assessment of diagnostic enzyme-linked immunosorbent assay kit and serological markers in human brucellosis. (18806343)
2008
42
Severe pharyngitis in stockbreeders: an unusual presentation of brucellosis. (18397911)
2008
43
Association between the Phe206Leu polymorphism of L-selectin and brucellosis. (16585636)
2006
44
Meningoencephalitis, pancytopenia, pulmonary insufficiency and splenic abscess in a patient with brucellosis. (16598314)
2006
45
Frequency analysis of the CCR5delta32 mutation in patients with brucellosis. (12587636)
2002
46
Diagnostic usefulness of antibodies against ribosome recycling factor from Brucella melitensis in human or canine brucellosis. (11874879)
2002
47
Brucellosis with acute acalculous cholecystitis. (11099103)
2000
48
Occurrence of antibodies to the etiologic agents of infectious bovine rhinotracheitis, parainfluenza 3, leptospirosis, and brucellosis in white-tailed deer in Minnesota. (3005666)
1986
49
Effect of atrophic rhinitis vaccines on the reaction of pigs to serological tests for brucellosis. (4049708)
1985
50
Ovine brucellosis: a review of the disease in sheep manifested by epididymitis and abortion. (14463013)
1961

Variations for Brucellosis

About this section

Expression for genes affiliated with Brucellosis

About this section
Search GEO for disease gene expression data for Brucellosis.

Pathways for genes affiliated with Brucellosis

About this section

Compounds for genes affiliated with Brucellosis

About this section

Compounds related to Brucellosis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1colchicine43 59 2 28 1213.7MEFV, SAA1
2endotoxin439.4CD14, MEFV, SAA1
3tuberculin439.3CD14, ADA
4hypoxanthine43 24 1211.3ADA, CD14
5xanthine43 2410.3CD14, ADA
6neopterin439.2ADA, CD14
7alanine438.7CD14, SAA1, ADA
8aspartate438.6SLC11A1, CD14, ADA
9dexamethasone43 49 28 1211.6CD14, SAA1, ADA
10arginine438.4ADA, SAA1, CD14

GO Terms for genes affiliated with Brucellosis

About this section

Cellular components related to Brucellosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1spermatoproteasome complexGO:019901119.5PSMB8, PSMB9
2proteasome core complexGO:00058399.4PSMB8, PSMB9
3proteasome complexGO:00005029.2PSMB9, PSMB8
4extracellular vesicular exosomeGO:00700628.6CD14, PSMB8, PSMB9, SAA1

Biological processes related to Brucellosis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytokine secretionGO:00507159.8CD14, SAA1
2regulation of cellular amino acid metabolic processGO:00065219.8PSMB9, PSMB8
3negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleGO:00514369.8PSMB8, PSMB9
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.7PSMB8, PSMB9
5positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleGO:00514379.7PSMB8, PSMB9
6regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleGO:00514399.7PSMB9, PSMB8
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00024799.7PSMB9, PSMB8
8antigen processing and presentation of exogenous peptide antigen via MHC class IGO:00425909.6PSMB8, PSMB9
9phagocytosisGO:00069099.6CD14, SLC11A1
10anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processGO:00311459.6PSMB9, PSMB8
11antigen processing and presentation of peptide antigen via MHC class IGO:00024749.5PSMB9, PSMB8
12regulation of apoptotic processGO:00429819.5PSMB8, PSMB9
13inflammatory responseGO:00069549.2SLC11A1, CD14, MEFV
14protein polyubiquitinationGO:00002099.2PSMB8, PSMB9
15negative regulation of inflammatory responseGO:00507289.2MEFV, SAA1, ADA
16innate immune responseGO:00450879.1CD14, MEFV, SAA1
17apoptotic processGO:00069159.0CD14, PSMB8, PSMB9

Molecular functions related to Brucellosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1threonine-type endopeptidase activityGO:00042989.5PSMB8, PSMB9

Products for genes affiliated with Brucellosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Brucellosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet