MCID: BRC012
MIFTS: 63

Brucellosis malady

Infectious diseases category

Summaries for Brucellosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that is caused by the bacteria of the genus brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. the disease has symptom fever, has symptom sweat, has symptom headache, has symptom back pain, has symptom physical weakness, has symptom joint pain and has symptom fatigue.

MalaCards: Brucellosis, also known as undulant fever, is related to tuberculosis and hepatitis, and has symptoms including fatigue, joint pain and physical weakness. An important gene associated with Brucellosis is SAA1 (serum amyloid A1), and among its related pathways are Primary immunodeficiency and C-MYB transcription factor network. The compounds alpha-naphthyl butyrate and colchicine have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and t cells, and related mouse phenotypes are hematopoietic system and immune system.

CDC:3 Brucellosis is an infectious disease caused by bacteria.

Wikipedia:63 Brucellosis, also called Bang\'s disease, Crimean fever, Gibraltar fever, Malta fever, Maltese fever,... more...

Aliases & Classifications for Brucellosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

brucellosis 8 42 10 44 48 60
undulant fever 8 42
gibraltar fever 42
maltese fever 8
cyprus fever 42
malta fever 42
rock fever 42


External Ids:

Disease Ontology8 DOID:11077
ICD9CM27 023.9, 023
NCIt39 C84602
MESH via Orphanet35 D002006
SNOMED-CT via Orphanet57 75702008
ICD10 via Orphanet26 A23.0, A23.1, A23.2 A23.3, A23.8, A23.9, more
UMLS via Orphanet61 C0006309

Related Diseases for Brucellosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Brucellosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.5BLZF1, SLC11A1, ADA, LYZ
2hepatitis30.3ANPEP
3arthritis30.1SAA1, PSMB9, MEFV, ANPEP, TAP2, FCGR2A
4meningitis29.9LYZ, ADA, FCGR2A
5hepatitis c29.7TAP2
6vasculitis29.7MEFV, BLZF1, CD14
7acute leukemia29.7ANPEP, BLZF1, CD14
8deficiency anemia29.7SAA1, FCGR2A, SLC11A1
9leukemia29.7PSMB8, ANPEP, BLZF1, CD14, TAP1, TAP2
10brucella melitensis brucellosis10.4
11brucella abortus brucellosis10.4
12pancytopenia10.4
13leptospirosis10.3
14orchitis10.3
15q fever10.3
16brucella canis brucellosis10.3
17epididymo-orchitis10.3
18brucella suis brucellosis10.3
19epidural abscess10.2
20thrombocytopenia10.2
21endocarditis10.2
22hemolytic anemia10.2
23splenic abscess10.1
24cervicitis10.1
25purpura10.1
26tick-borne relapsing fever10.1
27relapsing fever10.1
28rhinotracheitis10.1
29autoimmune hemolytic anemia10.1
30extrapulmonary tuberculosis10.1
31toxoplasmosis10.1
32crohn's disease10.0LYZ
33ulcerative colitis10.0LYZ
34celiac disease10.0MICA
35familial mediterranean fever10.0MEFV, SAA1
36alzheimer's disease10.0BLZF1
37intestinal tuberculosis10.0PSMB9
38myelitis10.0
39thrombotic thrombocytopenic purpura10.0
40capillary leak syndrome10.0
41cholestasis10.0
42glomerulonephritis10.0
43infective endocarditis10.0
44myositis10.0
45panniculitis10.0
46pericardial effusion10.0
47polyneuropathy10.0
48tularemia10.0
49amyloidosis10.0SAA1, MEFV, LYZ
50diabetes mellitus10.0TAP1, CD14

Graphical network of the top 20 diseases related to Brucellosis:



Diseases related to brucellosis

Clinical Features for Brucellosis

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 7)
  • fatigue
  • joint pain
  • physical weakness
  • back pain
  • headache
  • sweat
  • fever

Drugs & Therapeutics for Brucellosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Brucellosis

Drug clinical trials:

Search ClinicalTrials for Brucellosis

Search NIH Clinical Center for Brucellosis

Search CenterWatch for Brucellosis

Genetic Tests for Brucellosis

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Anatomical Context for Brucellosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Brucellosis:

32
Testes, Liver, T cells, Bone, Bone marrow, Skin, Breast, Prostate, Testis, Monocytes, Pons, Spinal cord, Whole blood

Animal Models for Brucellosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Brucellosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.8PSMB9, MEFV, ANPEP, TAP1, TAP2, FCGR2A
2MP:00053879.4ADA, PSMB8, PSMB9, MEFV, ANPEP, CD14

Publications for Brucellosis

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Sources:
50PubMed
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Articles related to Brucellosis:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
Brucellosis as an aetiology of septic arthritis. (24231687)
2014
2
New developments in the immunodiagnosis of brucellosis in livestock and wildlife. (23837374)
2013
3
Pediatric Brucellosis: A Case Study. (24055070)
2013
4
Brucellosis in humans--etiology, diagnostics, clinical forms. (23772567)
2013
5
Bovine brucellosis trends in Malaysia between 2000 and 2008. (24246015)
2013
6
High-risk regions of human brucellosis in china: implications for prevention and early diagnosis of travel-related infections. (23595834)
2013
7
Risk factors associated with human brucellosis in the country of Georgia: a case-control study. (22404868)
2013
8
An evaluation of cattle farmers' knowledge of bovine brucellosis in northeast Portugal. (23999332)
2013
9
Epidemiology of brucellosis in domestic animals caused by Brucella melitensis, Brucella suis and Brucella abortus. (23837364)
2013
10
Development and comparative evaluation of a plate enzyme-linked immunosorbent assay based on recombinant outer membrane antigens Omp28 and Omp31 for diagnosis of human brucellosis. (23761658)
2013
11
Bone marrow biopsy findings in brucellosis patients with hematologic abnormalities: useful remarks. (23489826)
2013
12
Brucellosis and tuberculosis: clinical overlap and pitfalls. (23870473)
2013
13
Estimation of sensitivity and specificity of five serological tests for the diagnosis of porcine brucellosis. (22153032)
2012
14
Osteoarticular manifestations of brucellosis. (22937686)
2012
15
Human brucellosis in Tuzla Canton. (23097967)
2012
16
Acellular vaccines for ovine brucellosis: a safer alternative against a worldwide disease. (22149711)
2012
17
The human-animal interface of domestic livestock management and production and its relationship to brucellosis in the country of Georgia 2010: a rapid assessment analysis. (22405190)
2012
18
Comparative evaluation of the Rose Bengal plate test, standard tube agglutination test and complement fixation test for the diagnosis of human brucellosis. (23520751)
2012
19
Recombinant VirB5 protein as a potential serological marker for the diagnosis of bovine brucellosis. (22662340)
2012
20
Detection of orchitis and sacroiliitis due to brucellosis by 99mTc polyclonal human immunoglobulin scintigraphy. (22691509)
2012
21
Brucellosis: a neglected but existing threat to travelers and laboratory personnel in Taiwan. (22817811)
2012
22
Mannose-binding lectin gene codon 54 polymorphism susceptible to brucellosis in Turkish children. (23094532)
2012
23
Negative serology: could exclude the diagnosis of brucellosis? (20379819)
2012
24
Specific IgA antibodies in the diagnosis of acute brucellosis. (22337851)
2012
25
The pathophysiology of inhalational brucellosis in BALB/c mice. (22773944)
2012
26
Pediatric brucellosis: an (almost) forgotten disease. (22125040)
2011
27
Brucellosis as a cause of fever of unknown origin in children admitted to a tertiary hospital in the Aegean region of Turkey. (21254856)
2011
28
A comparison between doxycycline-rifampin and ciprofloxacin-rifampin regimens in the treatment of acute Brucellosis. (23511044)
2011
29
Epidemiology and management of a bovine brucellosis cluster in Northern Ireland. (21144605)
2011
30
Chest wall involvement as a manifestation of brucellosis. (21572615)
2011
31
Zoonotic brucellosis: an underestimated or misdiagnosed disease in Egypt. (21634240)
2011
32
Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century. (21571380)
2011
33
Brucellosis presenting as septic shock. (22701076)
2011
34
Evaluation of sensitivity and specificity of RBT, c-ELISA and fluorescence polarisation assay for diagnosis of brucellosis in cattle using latent class analysis. (21419497)
2011
35
Comparative analysis of the early transcriptome of Brucella abortus--infected monocyte-derived macrophages from cattle naturally resistant or susceptible to brucellosis. (20932540)
2011
36
The first outbreak of brucellosis in the region of Sabac. (20845665)
2010
37
Sexually transmitted brucellosis in humans. (20550455)
2010
38
A rare hematological manifestation of brucellosis: reactive hemophagocytic syndrome. (20457434)
2010
39
Does brucellosis in human pregnancy increase abortion risk? Presentation of two cases and review of literature. (20492399)
2010
40
No association of TAP and LMP genetic polymorphism in human brucellosis and its complications. (20470844)
2010
41
Expression and validation of D-erythrulose 1-phosphate dehydrogenase from Brucella abortus: a diagnostic reagent for bovine brucellosis. (20622221)
2010
42
Evaluation of some diagnostic methods for the brucellosis in humans - a five year study. (20703185)
2010
43
Primary peritonitis due to brucellosis mimicking tuberculous peritonitis. (19530047)
2009
44
Transforming growth factor-beta1 polymorphisms in patients with brucellosis: an association between codon 10 and 25 polymorphisms and brucellosis. (17184296)
2007
45
Cytokine levels in patients with brucellosis and their relations with the treatment. (18087091)
2007
46
Meningoencephalitis, pancytopenia, pulmonary insufficiency and splenic abscess in a patient with brucellosis. (16598314)
2006
47
Large cell calcifying Sertoli cell tumor of the testis in a boy with brucellosis. (16970792)
2006
48
Association of interleukin-1 receptor antagonist gene polymorphism and susceptibility to human brucellosis. (17026469)
2006
49
A case of metastatic spinal Ewing's sarcoma misdiagnosed as brucellosis and transverse myelitis. (14767689)
2004
50
Occurrence of antibodies to the etiologic agents of infectious bovine rhinotracheitis, parainfluenza 3, leptospirosis, and brucellosis in white-tailed deer in Minnesota. (3005666)
1986

Genetic Variations for Brucellosis

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Expression for genes affiliated with Brucellosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brucellosis

Search GEO for disease gene expression data for Brucellosis.

Pathways for genes affiliated with Brucellosis

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Brucellosis

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Sources:
44Novoseek, 59Tocris Bioscience, 2BitterDB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Brucellosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alpha-naphthyl butyrate4410.5CD14, ANPEP
2colchicine59 44 2 28 1114.3ANPEP, MEFV, SAA1
3glutamine4410.2ADA, FCGR2A, TAP2, TAP1, CD14, BLZF1
4sucrose44 11 2412.2ANPEP, BLZF1, CD14, LYZ
5alanine4410.1SAA1, ANPEP, BLZF1, CD14, TAP1, TAP2
6arginine4410.1SAA1, ANPEP, BLZF1, CD14, FCGR2A, ADA
7atp44 2811.1ANPEP, BLZF1, CD14, TAP1, TAP2, FCGR2A
8oligonucleotide4410.1FCGR2A, TAP2, TAP1, CD14, ANPEP
9tuberculin4410.0ADA, CD14
10cholesterol44 28 11 2413.0SAA1, ANPEP, BLZF1, CD14, FCGR2A

GO Terms for genes affiliated with Brucellosis

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16Gene Ontology
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Cellular components related to Brucellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:04282510.3TAP2, TAP1
2spermatoproteasome complexGO:199011110.2PSMB9, PSMB8
3cell surfaceGO:00998610.1ADA, CD14, MICA, SYNJ2BP
4proteasome core complexGO:00583910.0PSMB8, PSMB9

Biological processes related to Brucellosis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.5TAP2, TAP1
2intracellular transport of viral proteins in host cellGO:01906010.5TAP2, TAP1
3negative regulation of inflammatory responseGO:05072810.4SAA1, MEFV, ADA
4peptide transportGO:01583310.4TAP2, TAP1
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.4TAP2, TAP1, PSMB9, PSMB8
6antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259010.4PSMB8, PSMB9, TAP1, TAP2
7antigen processing and presentation of peptide antigen via MHC class IGO:00247410.4PSMB8, PSMB9, TAP1, TAP2
8antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.4TAP2, TAP1
9cytolysisGO:01983510.3LYZ, MICA
10inflammatory responseGO:00695410.2MEFV, CD14, SLC11A1, LYZ
11defense response to bacteriumGO:04274210.1MICA, SLC11A1, LYZ
12modulation by virus of host morphology or physiologyGO:0190489.8MICA, ANPEP, PSMB9, PSMB8

Molecular functions related to Brucellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide transporter activityGO:01519710.4TAP2, TAP1
2tapasin bindingGO:04698010.4TAP2, TAP1
3TAP2 bindingGO:04697910.3TAP1, TAP2
4MHC class I protein bindingGO:04228810.3TAP2, TAP1
5TAP1 bindingGO:04697810.2TAP1, TAP2
6oligopeptide-transporting ATPase activityGO:01542110.0TAP1, TAP2

Products for genes affiliated with Brucellosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brucellosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet