MCID: BRC012
MIFTS: 60

Brucellosis malady

Rare diseases, Infectious diseases categories
Download this MalaCard

Summaries for Brucellosis

About this section
Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Disease Ontology:8 A primary bacterial infectious disease that is caused by the bacteria of the genus brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. the disease has symptom fever, has symptom sweat, has symptom headache, has symptom back pain, has symptom physical weakness, has symptom joint pain and has symptom fatigue.

MalaCards: Brucellosis, also known as undulant fever, is related to arthritis and vasculitis, and has symptoms including fatigue, joint pain and physical weakness. An important gene associated with Brucellosis is MEFV (Mediterranean fever), and among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Presenilin-Mediated Signaling. The compounds colchicine and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and t cells, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:65 Brucellosis, also called Bang\'s disease, Crimean fever, Gibraltar fever, Malta fever, Maltese fever,... more...

Aliases & Classifications for Brucellosis

About this section
Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 27ICD9CM, 35MeSH, 58SNOMED-CT, 40NCIt, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Aliases & Descriptions:

brucellosis 8 43 10 45 49 62
undulant fever 8 43
gibraltar fever 43
maltese fever 8
cyprus fever 43
malta fever 43
rock fever 43


External Ids:

Disease Ontology8 DOID:11077
ICD9CM27 023, 023.9
NCIt40 C84602
MESH via Orphanet36 D002006
SNOMED-CT via Orphanet59 75702008
ICD10 via Orphanet26 A23.0, A23.1, A23.2 A23.3, A23.8, A23.9, more
UMLS via Orphanet63 C0006309

Related Diseases for Brucellosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Brucellosis:



Diseases related to brucellosis

Symptoms for Brucellosis

About this section
Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 7)
  • fatigue
  • joint pain
  • physical weakness
  • back pain
  • headache
  • sweat
  • fever

Drugs & Therapeutics for Brucellosis

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Brucellosis

Search NIH Clinical Center for Brucellosis

Genetic Tests for Brucellosis

About this section

Anatomical Context for Brucellosis

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Brucellosis:

33
Testes, Liver, T cells, Bone, Bone marrow, Skin, Breast, Prostate, Testis, Monocytes, Pons, Spinal cord, Whole blood

Animal Models for Brucellosis or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Brucellosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.2ADA, PSMB9, PSMB8, MEFV, CD14, SLC11A1
2MP:00053976.9ADA, PSMB9, PSMB8, MEFV, CD14, SLC11A1

Publications for Brucellosis

About this section
Sources:
52PubMed
See all sources

Articles related to Brucellosis:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
Herd-level risk factors for Campylobacter fetus infection, Brucella seropositivity and within-herd seroprevalence of brucellosis in cattle in northern Nigeria. (23830113)
2013
2
Bayesian estimation of true prevalence, sensitivity and specificity of indirect ELISA, Rose Bengal Test and Slow Agglutination Test for the diagnosis of brucellosis in sheep and goats in Bangladesh. (23276401)
2013
3
Prevalence and risk factors for brucellosis in goats in areas of Mexico with and without brucellosis control campaign. (23420068)
2013
4
Human brucellosis, a heterogeneously distributed, delayed, and misdiagnosed disease in china. (23175566)
2013
5
New developments in the immunodiagnosis of brucellosis in livestock and wildlife. (23837374)
2013
6
Time series analysis of human and bovine brucellosis in South Korea from 2005 to 2010. (23276400)
2013
7
Severe persistent thrombocytopenia as a sole manifestation of brucellosis. (22544672)
2013
8
Host-Brucella interactions and the Brucella genome as tools for subunit antigen discovery and immunization against brucellosis. (23720712)
2013
9
Antibiotic susceptibility and treatment of brucellosis. (22812615)
2013
10
Two-stage PCR assay for detection of human brucellosis in endemic areas. (23517532)
2013
11
Evidence of bovine viral diarrhea, but absence of infectious bovine rhinotracheitis and bovine brucellosis in the endangered huemul deer (Hippocamelus bisulcus) in Chilean Patagonia. (23778636)
2013
12
Risk factors associated with brucellosis seropositivity among cattle in the central savannah-forest area of Ivory Coast. (22704904)
2012
13
Laboratory-acquired brucellosis in Turkey. (22365915)
2012
14
Epidemiological and clinical aspects of human brucellosis in eastern Anatolia. (23123390)
2012
15
Estimation of sensitivity and specificity of five serological tests for the diagnosis of porcine brucellosis. (22153032)
2012
16
Brucellosis manifesting as chronic inflammatory demyelinating polyneuropathy. (22728867)
2012
17
Outcomes of treatment in 50 cases with spinal brucellosis in Babol, Northern Iran. (23000864)
2012
18
Application of the microagglutination test for serologic diagnosis of human brucellosis. (24159482)
2012
19
Brucellosis-induced avascular necrosis of the hip in a middle-aged person. (23641397)
2012
20
Osteoarticular manifestations of brucellosis. (22937686)
2012
21
Preliminary study of an immunochromatography test for serological diagnosis of canine brucellosis. (23279541)
2012
22
Brucellosis laboratory tests in Syria: what are their diagnostic efficacies in different clinical manifestations? (22706192)
2012
23
Assessment of performance of selected serological tests for diagnosing brucellosis in pigs. (22445082)
2012
24
Decreasing prevalence of brucellosis in red deer through efforts to control disease in livestock. (21676351)
2011
25
Seroprevalence of Brucellosis among high risk individuals in Guilan, Iran. (22973333)
2011
26
Seroprevalance of brucellosis among suspected cases in Malaysia. (21874749)
2011
27
Hepatic granulomas associated with brucellosis: Hepatic granulomas and brucellosis. (22087106)
2011
28
Lymphocyte activation test for diagnosis of seronegative brucellosis in humans. (22234109)
2011
29
Brucellosis of the European brown hare (Lepus europaeus). (21511271)
2011
30
Pleural and pericardial effusions: rare presentations of brucellosis, Iran. (21713754)
2011
31
Pediatric brucellosis: an (almost) forgotten disease. (22125040)
2011
32
Problems with the use of a lateral flow assay in the serodiagnosis of brucellosis. (22124267)
2011
33
Case report on the development of a brucellosis-related epidural abscess. (21628820)
2011
34
Lipopolysaccharide: a complex role in the pathogenesis of brucellosis. (20702124)
2011
35
Quantifying risk factors for human brucellosis in rural northern Tanzania. (20376363)
2010
36
Superior mesenteric artery syndrome secondary to brucellosis - A case report. (23133263)
2010
37
Brucellosis in northern Australia. (20889883)
2010
38
Ovine and Caprine Brucellosis (Brucella melitensis) in Aborted Animals in Jordanian Sheep and Goat Flocks. (21052561)
2010
39
Gaps in brucellosis eradication campaign in sheep and goats in Republic of Macedonia: lessons learned. (20718089)
2010
40
Prevalence of brucellosis and infectious bovine rhinotracheitis in organized dairy farms in India. (19644761)
2010
41
Assessment of diagnostic enzyme-linked immunosorbent assay kit and serological markers in human brucellosis. (18806343)
2008
42
Severe pharyngitis in stockbreeders: an unusual presentation of brucellosis. (18397911)
2008
43
Association between the Phe206Leu polymorphism of L-selectin and brucellosis. (16585636)
2006
44
Meningoencephalitis, pancytopenia, pulmonary insufficiency and splenic abscess in a patient with brucellosis. (16598314)
2006
45
Frequency analysis of the CCR5delta32 mutation in patients with brucellosis. (12587636)
2002
46
Diagnostic usefulness of antibodies against ribosome recycling factor from Brucella melitensis in human or canine brucellosis. (11874879)
2002
47
Brucellosis with acute acalculous cholecystitis. (11099103)
2000
48
Occurrence of antibodies to the etiologic agents of infectious bovine rhinotracheitis, parainfluenza 3, leptospirosis, and brucellosis in white-tailed deer in Minnesota. (3005666)
1986
49
Effect of atrophic rhinitis vaccines on the reaction of pigs to serological tests for brucellosis. (4049708)
1985
50
Ovine brucellosis: a review of the disease in sheep manifested by epididymitis and abortion. (14463013)
1961

Variations for Brucellosis

About this section

Expression for genes affiliated with Brucellosis

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Brucellosis

Search GEO for disease gene expression data for Brucellosis.

Pathways for genes affiliated with Brucellosis

About this section
Sources:
50PathCards, 55Reactome, 53QIAGEN
See all sources

Compounds for genes affiliated with Brucellosis

About this section
Sources:
45Novoseek, 61Tocris Bioscience, 3BitterDB, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB
See all sources

Compounds related to Brucellosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1colchicine45 61 3 29 1113.7MEFV, SAA1
2endotoxin459.4CD14, MEFV, SAA1
3tuberculin459.3CD14, ADA
4hypoxanthine45 24 1111.3ADA, CD14
5xanthine45 2410.3CD14, ADA
6neopterin459.2ADA, CD14
7alanine458.7CD14, SAA1, ADA
8aspartate458.6SLC11A1, CD14, ADA
9dexamethasone45 51 29 1111.6CD14, SAA1, ADA
10arginine458.4ADA, SAA1, CD14

GO Terms for genes affiliated with Brucellosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Brucellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spermatoproteasome complexGO:19901119.5PSMB9, PSMB8
2proteasome core complexGO:0058399.4PSMB8, PSMB9
3proteasome complexGO:0005029.2PSMB8, PSMB9
4extracellular vesicular exosomeGO:0700628.6CD14, PSMB9, SAA1, PSMB8

Biological processes related to Brucellosis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytokine secretionGO:0507159.8SAA1, CD14
2regulation of cellular amino acid metabolic processGO:0065219.8PSMB9, PSMB8
3negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleGO:0514369.8PSMB8, PSMB9
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.7PSMB9, PSMB8
5positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleGO:0514379.7PSMB9, PSMB8
6regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleGO:0514399.7PSMB8, PSMB9
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.7PSMB9, PSMB8
8antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.6PSMB8, PSMB9
9phagocytosisGO:0069099.6SLC11A1, CD14
10anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processGO:0311459.6PSMB9, PSMB8
11antigen processing and presentation of peptide antigen via MHC class IGO:0024749.5PSMB8, PSMB9
12regulation of apoptotic processGO:0429819.5PSMB8, PSMB9
13inflammatory responseGO:0069549.2CD14, SLC11A1, MEFV
14protein polyubiquitinationGO:0002099.2PSMB9, PSMB8
15negative regulation of inflammatory responseGO:0507289.2ADA, MEFV, SAA1
16innate immune responseGO:0450879.1CD14, SAA1, MEFV
17apoptotic processGO:0069159.0PSMB9, CD14, PSMB8

Molecular functions related to Brucellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1threonine-type endopeptidase activityGO:0042989.5PSMB8, PSMB9

Products for genes affiliated with Brucellosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brucellosis

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet