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MCID: BRC012
MIFTS: 66

Brucellosis malady

Categories: Rare diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Brucellosis

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Aliases & Descriptions for Brucellosis:

Name: Brucellosis 12 50 56 52 3 42 14 69
Undulant Fever 12 50 3
Gibraltar Fever 12 50
Malta Fever 12 50
Mediterranean Fever 12
Bang's Disease 12
Maltese Fever 12
Cyprus Fever 50
Rock Fever 50

Characteristics:

Orphanet epidemiological data:

56
brucellosis
Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11077
ICD9CM 35 023 023.9
MeSH 42 D002006
NCIt 47 C84602
Orphanet 56 ORPHA1304
ICD10 via Orphanet 34 A23.3 A23.8 A23.9 more
UMLS via Orphanet 70 C0006309
MESH via Orphanet 43 D002006
UMLS 69 C0006309
Sources

Summaries for Brucellosis

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NIH Rare Diseases : 50 brucellosis is a bacterial infection that spreads from animals to people via unpasteurized dairy products or by exposure to contaminated animal products or infected animals. animals that are most commonly infected include sheep, cattle, goats, pigs, and dogs. brucellosis can cause of range of signs and symptoms, some of which may persist or recur. initial symptoms may include fever, sweats, malaise, anorexia, headache, fatigue, and/or pain in the muscles, joints, and/or back. symptoms that may persist or recur include fevers, arthritis, swelling of the testicle and scrotum, swelling of the heart (endocarditis), neurologic symptoms (in up to 5% of cases), chronic fatigue, depression, and/or swelling of the liver or spleen. people who are in jobs or settings that increase exposure to the bacteria are at increased risk for infection. antibiotics are used to treat brucellosis. recovery may take a few weeks to several months, and relapses are common. death from brucellosis is rare, occurring in no more than 2% of cases. last updated: 12/12/2014

MalaCards based summary : Brucellosis, also known as undulant fever, is related to tuberculosis and hepatitis, and has symptoms including fever, sweat and headache. An important gene associated with Brucellosis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Abatacept and Mycophenolate mofetil have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Disease Ontology : 12 A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has symptom fever, has symptom sweat, has symptom headache, has symptom back pain, has symptom physical weakness, has symptom joint pain and has symptom fatigue.

Wikipedia : 71 Brucellosis is a highly contagious zoonosis caused by ingestion of unpasteurized milk or undercooked... more...

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Related Diseases for Brucellosis

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Diseases related to Brucellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 471)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 29.9 CD40LG IL10 IL2 IL4 IL6 TNF
2 hepatitis 29.9 IFNG IL10 IL2 IL6 TNF
3 tularemia 29.4 CD40LG IFNG IL10 IL2 IL4 TNF
4 rift valley fever 29.4 CRP IFNG IL6 SLC11A1 TLR4 TNF
5 nervous system cancer 28.9 CXCL8 IFNG IL10 IL4 IL6 TGFB1
6 familial mediterranean fever, ar 12.5
7 familial mediterranean fever, ad 12.3
8 brucella melitensis brucellosis 12.2
9 brucella abortus brucellosis 12.2
10 brucella canis brucellosis 12.1
11 brucella suis brucellosis 12.0
12 familial mediterranean fever type 1 12.0
13 familial mediterranean fever type 2 12.0
14 amyloidosis aa 10.8
15 amyloidosis, hereditary, transthyretin-related 10.8
16 amyloidosis 10.5
17 refractory celiac disease 10.3 IL10 TGFB1
18 myoglobinuria recurrent 10.3 IFNG IL4
19 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
20 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
21 distal trisomy 14q 10.3 IFNG TGFB1 TNF
22 anal paget's disease 10.3 IL6 TGFB1 TNF
23 preaxial polydactyly of fingers 10.3 IL6 TGFB1 TNF
24 lepromatous leprosy 10.3 IFNG IL10 IL6
25 discharging ear 10.3 IFNG IL10 TGFB1
26 maturity-onset diabetes of the young 10.3 CD40LG IL10
27 urethral intrinsic sphincter deficiency 10.3 IFNG IL4 TNF
28 tungiasis 10.3 IFNG IL10 IL4
29 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 IL4 TNF
30 hypotrichosis 4 10.3 IFNG IL4 TNF
31 hereditary night blindness 10.3 IL6 TGFB1 TNF
32 pulpitis 10.3 IFNG IL10 TNF
33 immune-complex glomerulonephritis 10.3 IFNG IL4 IL6
34 phlyctenulosis 10.3 IL10 IL6 TNF
35 lagophthalmos 10.2 IL10 IL4 TNF
36 cataract, total congenital 10.2 CRP IFNG IL6
37 vestibule of mouth cancer 10.2 IL10 IL4 TNF
38 bladder signet ring cell adenocarcinoma 10.2 IL10 IL6 TNF
39 coloboma of iris 10.2 CRP IL6
40 hemangioma of spleen 10.2 CRP IFNG IL6
41 reproductive system disease 10.2 CD40LG IL10 IL6
42 childhood pleomorphic rhabdomyosarcoma 10.2 CD40LG IL6 TNF
43 unilateral multicystic dysplastic kidney 10.2 CRP IL6 TNF
44 swine influenza 10.2 CRP IL6 TNF
45 mineral metabolism disease 10.2 CD40LG IL6 TNF
46 orbit alveolar rhabdomyosarcoma 10.2 IL10 IL4 TGFB1
47 central nervous system lymphoma 10.2 IL10 IL6 TNF
48 diabetic angiopathy 10.2 CD40LG IL10 IL4
49 benign deep fibrous histiocytoma 10.2 CD40LG IFNG TNF
50 steatitis 10.2 IL2 TNF

Graphical network of the top 20 diseases related to Brucellosis:



Diseases related to Brucellosis
Sources

Symptoms & Phenotypes for Brucellosis

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Symptoms:

12
  • • fever
  • • sweat
  • • headache
  • • back pain
  • • physical weakness
  • • joint pain
  • • fatigue

GenomeRNAi Phenotypes related to Brucellosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CD40LG CXCL8 IL10 IL2 IL2RA TGFB1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CD40LG CXCL8 IL10 IL2 IL2RA TGFB1

MGI Mouse Phenotypes related to Brucellosis:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 CD40LG IFNG IL10 IL1RN IL2 IL2RA
2 immune system MP:0005387 10.3 CD40LG CRP IFNG IL10 IL1RN IL2
3 cellular MP:0005384 10.29 CD40LG IFNG IL10 IL1RN IL2 IL4
4 homeostasis/metabolism MP:0005376 10.29 CD40LG CRP IFNG IL10 IL1RN IL2
5 cardiovascular system MP:0005385 10.26 IFNG IL10 IL1RN IL2 IL6 TGFB1
6 growth/size/body region MP:0005378 10.25 IL10 IL1RN IL2 IL2RA IL4 IL6
7 digestive/alimentary MP:0005381 10.24 IL10 IL2 IL2RA IL4 IL6 SLC11A1
8 endocrine/exocrine gland MP:0005379 10.18 CD40LG IFNG IL10 IL2 IL2RA IL4
9 mortality/aging MP:0010768 10.18 IL2RA IL4 IL6 MEFV SLC11A1 TGFB1
10 integument MP:0010771 10.13 CD40LG IFNG IL10 IL1RN IL4 IL6
11 liver/biliary system MP:0005370 10.06 IFNG IL10 IL2 IL4 IL6 MEFV
12 reproductive system MP:0005389 10 CD40LG IFNG IL10 IL1RN IL2 IL4
13 neoplasm MP:0002006 9.92 IFNG IL10 IL2 IL6 SLC11A1 TGFB1
14 respiratory system MP:0005388 9.81 TNF IFNG IL10 IL2 IL2RA IL4
15 skeleton MP:0005390 9.65 MEFV TGFB1 TLR4 TNF CD40LG IFNG
16 vision/eye MP:0005391 9.28 IFNG IL10 IL2 IL2RA IL4 IL6
Sources

Drugs & Therapeutics for Brucellosis

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Drugs for Brucellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 763)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 4 332348-12-6 10237
2
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
3
Mycophenolic acid Approved Phase 4 24280-93-1 446541
4
Tacrolimus Approved, Investigational Phase 4,Phase 3 104987-11-3 445643 439492
5
Atenolol Approved Phase 4 29122-68-7 2249
6
Nicorandil Approved Phase 4 65141-46-0 47528
7
Colchicine Approved Phase 4,Phase 3,Phase 2,Phase 1 64-86-8 6167 2833
8
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
9
Methyltestosterone Approved Phase 4,Phase 3 58-18-4 6010
10
Testosterone Approved, Investigational Phase 4,Phase 3 58-22-0 6013
11
Heroin Approved, Illicit Phase 4 561-27-3 5462328
12
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
13
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
14
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
15
Adenosine Approved, Investigational Phase 4,Phase 2 58-61-7 60961
16
Clarithromycin Approved Phase 4,Early Phase 1 81103-11-9 84029
17
Maraviroc Approved, Investigational Phase 4 376348-65-1 3002977
18
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
19
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
20
Telavancin Approved Phase 4 372151-71-8
21
Oseltamivir Approved Phase 4,Phase 3 204255-11-8, 196618-13-0 65028
22
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
23
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991
24
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
25
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
26
Vancomycin Approved Phase 4 1404-90-6 441141 14969
27
Nicotine Approved Phase 4 54-11-5 942 89594
28
Citalopram Approved Phase 4,Phase 3,Phase 2 59729-33-8 2771
29
Donepezil Approved Phase 4,Phase 2 120014-06-4 3152
30
Norepinephrine Approved Phase 4,Phase 2 51-41-2 439260
31
Zinc Approved Phase 4,Phase 2 7440-66-6 32051 23994
32
Memantine Approved, Investigational Phase 4,Phase 2 19982-08-2 4054
33
Amodiaquine Approved Phase 4,Phase 3 86-42-0 2165
34
Artesunate Approved Phase 4,Phase 3 88495-63-0 6917864 5464098
35
Selegiline Approved, Investigational, Vet_approved Phase 4 14611-51-9 26757 5195
36
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
37
Dapsone Approved, Investigational Phase 4 80-08-0 2955
38
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
39
Ibuprofen Approved Phase 4 15687-27-1 3672
40
Naproxen Approved, Vet_approved Phase 4,Phase 2 22204-53-1 1302 156391
41
Ramipril Approved Phase 4 87333-19-5 5362129
42
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
43
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 1 616-91-1 12035
44
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
45
Sertraline Approved Phase 4 79617-96-2 68617
46
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
47
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 1 437-38-7 3345
48
Ketamine Approved, Vet_approved Phase 4,Phase 1,Phase 2 6740-88-1 3821
49
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2 57-27-2 5288826
50
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 2 76-42-6 5284603

Interventional clinical trials:

(show top 50) (show all 858)
id Name Status NCT ID Phase
1 VeinViewer Assisted Intravenous Catheter Placement in the Pediatric Emergency Department Unknown status NCT00468065 Phase 4
2 Comparison of NODAT in Kidney Transplant Patients Receiving Belatacept Versus Standard Immunosuppression Unknown status NCT01875224 Phase 4
3 Study to Assess Efficacy of Nicorandil+Atenolol vs Atenolol in Treatment of Chronic Stable Angina. Unknown status NCT01397994 Phase 4
4 Injection Assistance Device Versus Manual Injections for Delivery of Dermal Fillers Unknown status NCT01492140 Phase 4
5 Study of Long-Term Peg Intron Vs. Colchicine in Non-Responders. Unknown status NCT00179413 Phase 4
6 Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal Men Unknown status NCT01699178 Phase 4
7 Nasal Naloxone for Narcotic Overdose Unknown status NCT01912573 Phase 4
8 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
9 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Phase 4
10 The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With FMF Completed NCT02602028 Phase 4
11 A Study of the Neurological Effects of Adding Maraviroc to HAART Regimen in Patients With HIV (HANDmac) Completed NCT01449006 Phase 4
12 Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD) Completed NCT00663403 Phase 4
13 Cardiac Limitations in Chronic Obstructive Pulmonary Disease: Benefits of Bronchodilation Completed NCT00578968 Phase 4
14 Pharmacokinetics of Single-Dose Oral Ranolazine in Hemodialysis Patients Completed NCT01435174 Phase 4
15 Effect of Dialysis on the Pharmacokinetics of Telavancin in Patients With Chronic Kidney Disease Stage 5 Completed NCT02392208 Phase 4
16 Pharmacokinetics of Tamiflu® (Oseltamivir) in Patients Receiving Extracorporeal Membrane Oxygenation (ECMO)and or Continuous Venovenous Hemodialysis (CVVHD) Completed NCT01048879 Phase 4
17 Pharmacokinetics of Ertapenem in Continuous Venovenous Hemodialysis Completed NCT00877370 Phase 4
18 The Effects of the Rivastigmine Patch on Parkinson's Disease With Memory and/or Thinking Problems Completed NCT00988117 Phase 4
19 Rural Andhra Pradesh Cardiovascular Prevention Study (RAPCAPS) Completed NCT00263393 Phase 4
20 ULTRA Study for Pacemaker Patients Completed NCT00133289 Phase 4
21 Effect of Age on Latanoprost 0.005% in Patients With Glaucoma Completed NCT00224289 Phase 4
22 Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas Completed NCT00295178 Phase 4
23 Helping Those With Mental Illness Quit Smoking Completed NCT01783912 Phase 4
24 Ankle Block Versus Popliteal Fossa Block as Primary Anesthesia for Forefoot Surgical Procedures Completed NCT01376960 Phase 4
25 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
26 Antidepressant Medication Plus Donepezil for Treating Late-life Depression Completed NCT00177671 Phase 4
27 Needle Length In Obese Insulin-Using Diabetic Subjects Completed NCT00541372 Phase 4
28 Foot and Ankle Clinic Application for Liposomal Related Anesthetic Completed NCT02586077 Phase 4
29 Comparative Performance of PureVision, Acuvue Oasys and O2Optix Completed NCT00640341 Phase 4
30 Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia Completed NCT00545974 Phase 4
31 Safety and Acceptability of the PrePexâ„¢ Device for Male Circumcision in Zambia Completed NCT01844102 Phase 4
32 Restricting the Use of Artesunate Plus Amodiaquine Combination Therapy to Malaria Cases Confirmed by a Dipstick Test: A Cluster Randomised Control Trial Completed NCT00832754 Phase 4
33 Phase IV:Safety and Efficacy of EMSAM in Adolescents With Major Depression Completed NCT00531947 Phase 4
34 Evaluation of Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea® vs Placebo Completed NCT01308619 Phase 4
35 Phase IV Study to Gather More Information About the Safety of ACZONE Gel, 5% in Treating Subjects With Acne Who Have G6PD Deficiency Completed NCT00243542 Phase 4
36 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Completed NCT00346216 Phase 4
37 Effectiveness and Safety of Ramipril Alone Compared With Telmisartan Alone and in Combination With Ramipril in Patients at High Risk for Cardiovascular Events. Patients Intolerant to Ramipril Were Entered in TRANSCEND, Telmisartan Compared to Placebo. Completed NCT00153101 Phase 4
38 Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease Recruiting NCT02476526 Phase 4
39 Corticosteroids With Vedolizumab in Crohn's Disease Recruiting NCT02324699 Phase 4
40 International Study to Predict Optimised Treatment - in Depression Recruiting NCT00693849 Phase 4
41 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT00867815 Phase 4
42 A Study of Two Different Doses of Cabozantinib (XL184) in Progressive, Metastatic Medullary Thyroid Cancer Recruiting NCT01896479 Phase 4
43 Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study Recruiting NCT02202369 Phase 4
44 AAA Registry: Clinical Outcomes of Highly Angulated anatomY Treated With the Aorfixâ„¢ Stent Graft Recruiting NCT02480595 Phase 4
45 A Prospective Study of the InterFuse T(tm), Recruiting NCT02678130 Phase 4
46 Sleep and Cognition After Atripla to Stribild Switch Recruiting NCT02283060 Phase 4
47 Integrated Dual Exercise and Lexiscan Positron Emission Tomography: IDEALPET Active, not recruiting NCT01109992 Phase 4
48 Reducing the Acute Care Burden of Childhood Asthma on Health Services in British Columbia Active, not recruiting NCT01326494 Phase 4
49 Long-term Safety, Curvature Deformity Characterization, and Immunogenicity Over Time in Subjects Previously Treated With AA4500 for Peyronies Disease Active, not recruiting NCT02298829 Phase 4
50 World-wide Randomized Antibiotic Envelope Infection Prevention Trial Enrolling by invitation NCT02277990 Phase 4

Search NIH Clinical Center for Brucellosis

Cochrane evidence based reviews: brucellosis

Sources

Genetic Tests for Brucellosis

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Sources

Anatomical Context for Brucellosis

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MalaCards organs/tissues related to Brucellosis:

39
Testes, Liver, Heart, Spleen, T Cells, Bone, Bone Marrow
Sources

Publications for Brucellosis

About this section

Articles related to Brucellosis:

(show top 50) (show all 723)
id Title Authors Year
1
Intestinal brucellosis associated with celiac artery and superior mesenteric artery stenosis and with ileum mucosa and submucosa thickening: A case report. ( 28079834 )
2017
2
Brucellosis and thrombosis of the inferior vena cava. ( 27871206 )
2017
3
A serosurvey for ruminant pestivirus exposure conducted using cattle sera collected for brucellosis surveillance in the United States. ( 28074709 )
2017
4
Are brucellosis, Q fever and melioidosis potential causes of febrile illness in Madagascar? ( 28502643 )
2017
5
Brucellosis as a neglected disease in a neglected population: a seroepidemiological study of migratory nomads in the Fars province of Iran. ( 27866494 )
2017
6
The IL4-VNTR P1 Allele, IL4-VNTR P2P2 Genotype, and IL4-VNTR_IL6-174CG P2P1-GG Genotype Are Associated with an Increased Risk of Brucellosis. ( 27169944 )
2017
7
Seroepidemiology of Human Brucellosis Among Blood Donors in Southern Ethiopia: Calling Attention to a Neglected Zoonotic Disease. ( 28077743 )
2017
8
Is Human Brucellosis Endemics in Korea? ( 27873523 )
2017
9
Fludarabine is effective in treating refractory hemophagocytic lymphohistiocytosis with brucellosis. ( 28378406 )
2017
10
Clinical and diagnostic aspects of brucellosis and antimicrobial susceptibility of Brucella isolates in Hamedan, Iran. ( 27580575 )
2016
11
Brucellosis Outbreak in Children and Adults in Two Areas in Israel. ( 27114301 )
2016
12
[THE PERSPECTIVES OF STUDYING OF POLYMORPHISM OF GENES OF GAMMA-INTERFERON UNDER CHRONIC BRUCELLOSIS]. ( 27455566 )
2016
13
Brucellosis With Multi-Organ Involvement in a Patient With History of Composite Aortic Graft and Hepatitis B. ( 28033700 )
2016
14
Neurological Manifestations of Brucellosis in an Indian Population. ( 27555982 )
2016
15
Serological and molecular investigation for brucellosis in swine in selected districts of Uganda. ( 27142028 )
2016
16
Seroprevalence of human brucellosis in and around Jammu, India, using different serological tests. ( 27536036 )
2016
17
Utility of Serological Tests in the Era of Molecular Testing for Diagnosis of Human Brucellosis in Endemic Area with Limited Resources. ( 27042465 )
2016
18
A randomized, comparative study of dual therapy (doxycycline-rifampin) versus triple therapy (doxycycline-rifampin-levofloxacin) for treating acute/subacute brucellosis. ( 27086734 )
2016
19
Seroprevalence of brucellosis among cattle slaughtered in three municipal abattoirs of Gombe state, Northeastern Nigeria. ( 27847417 )
2016
20
Cervical Spondylitis and Epidural Abscess Caused by Brucellosis: a Case Report and Literature Review. ( 28068278 )
2016
21
Outbreak of Occupational Brucellosis at a Pharmaceutical Factory in Southeast China. ( 27863096 )
2016
22
Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis. ( 27722176 )
2016
23
Progressive encephalomyelitis with rigidity and myoclonus (PERM): brucellosis as a possible triggering factor and long-term follow-up therapy with rituximab. ( 26788132 )
2016
24
Imported brucellosis: A case series and literature review. ( 27185403 )
2016
25
Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. ( 27658298 )
2016
26
A very rare complication of brucellosis. ( 27583355 )
2016
27
Risk assessment and management of brucellosis in the southern greater Yellowstone area (I): A citizen-science based risk model for bovine brucellosis transmission from elk to cattle. ( 27664451 )
2016
28
Bayesian Estimation of Sensitivity and Specificity of Rose Bengal, Complement Fixation, and Indirect ELISA Tests for the Diagnosis of Bovine Brucellosis in Ethiopia. ( 27595036 )
2016
29
Pulmonary Involvement in Brucellosis, a Rare Complication of Renal Transplant: Case Report and Brief Review. ( 27210230 )
2016
30
Large-scale study of herd-level risk factors for bovine brucellosis in Brazil. ( 27664333 )
2016
31
Epidemiology of brucellosis, Q Fever and Rift Valley Fever at the human and livestock interface in northern CA'te d'Ivoire. ( 26899680 )
2016
32
Epidemiology of Brucellosis and Genetic Diversity of Brucella abortus in Kazakhstan. ( 27907105 )
2016
33
Diagnostic role of mean platelet volume and neutrophil to lymphocyte ratio in childhood brucellosis. ( 27951626 )
2016
34
Correction: Brucellosis Seropositivity in Animals and Humans in Ethiopia: A Meta-analysis. ( 27997550 )
2016
35
A Primary Investigation on Serum CTX-II Changes in Patients Infected with Brucellosis in Qinghai Plateau, China. ( 27109135 )
2016
36
Trend of human brucellosis over a decade at tertiary care centre in North Karnataka. ( 27934819 )
2016
37
Incidence Patterns and Occupational Risk Factors of Human Brucellosis in Greece, 2004-2015. ( 27651083 )
2016
38
Human brucellosis in South Africa: Public health and diagnostic pitfalls. ( 27601111 )
2016
39
Control of animal brucellosis: The Malaysian experience. ( 27955740 )
2016
40
Epidemic characteristics, high-risk townships and space-time clusters of human brucellosis in Shanxi Province of China, 2005-2014. ( 27993134 )
2016
41
Seroprevalence of Q Fever, Brucellosis, and Bluetongue in Selected Provinces in Lao People's Democratic Republic. ( 27430548 )
2016
42
Contagious Ecthyma, Rangiferine Brucellosis, and Lungworm Infection in a Muskox ( Ovibos moschatus ) from the Canadian Arctic, 2014. ( 27285415 )
2016
43
Seroprevalence of brucellosis among dairy farm workers in Mexico. ( 27598934 )
2016
44
The Syndrome of Inappropriate Secretion of Anti-Diuretic Hormone (SIADH) and Brucellosis. ( 27590789 )
2016
45
Recurrent Epistaxis and Bleeding as the Initial Manifestation of Brucellosis. ( 27107528 )
2016
46
First Case of Human Brucellosis Caused by Brucella melitensis in Korea. ( 27139618 )
2016
47
Analysis of IL-10 and IL-6 Gene Polymorphisms and Their Serum Levels in Patients with Brucellosis: A Case Control Study. ( 26849072 )
2016
48
Human Brucellosis in Febrile Patients Seeking Treatment at Remote Hospitals, Northeastern Kenya, 2014-2015. ( 27662463 )
2016
49
Latex agglutination using the periplasmic proteins antigen of Brucella melitensis is a successful, rapid, and specific serodiagnostic test for ovine brucellosis. ( 27207442 )
2016
50
TNF-I+ -238, -308, -863 polymorphisms, and brucellosis infection. ( 26585363 )
2016
Sources

Variations for Brucellosis

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Expression for Brucellosis

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Search GEO for disease gene expression data for Brucellosis.
Sources

Pathways for Brucellosis

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Pathways related to Brucellosis according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Super pathways Score Top Affiliating Genes
1
Innate Immune System 62
Show member pathways
 14.03 CD40LG CRP CXCL8 IFNG IL10 IL1RN
2
ERK Signaling 60
Show member pathways
 13.88 CD40LG CXCL8 IL10 IL2 IL2RA IL4
3
PEDF Induced Signaling 60
Show member pathways
 13.75 CD40LG CXCL8 IFNG IL10 IL2 IL2RA
4
TGF-Beta Pathway 60
Show member pathways
 13.62 CXCL8 IFNG IL10 IL2 IL2RA IL4
5
Akt Signaling 60
Show member pathways
 13.51 CD40LG CXCL8 IL10 IL2 IL2RA IL4
6
Cytokine Signaling in Immune system 62
Show member pathways
 13.46 CD40LG CXCL8 IFNG IL10 IL1RN IL2
7
PAK Pathway 60
Show member pathways
 13.42 CD40LG CXCL8 IL10 IL2 IL2RA IL4
8
IL-2 Pathway 60
Show member pathways
 13.23 IFNG IL2 IL2RA IL4 TLR4 TNF
9
Toll-Like receptor Signaling Pathways 61
Show member pathways
 13.06 CXCL8 IL1RN IL6 MEFV TLR4 TNF
10
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.04 CXCL8 IFNG IL10 IL2 IL6 TGFB1
11
Influenza A 37
Show member pathways
 12.93 CXCL8 IFNG IL2 IL2RA IL4 IL6
12
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 61
Show member pathways
 12.84 IL2 IL2RA IL4 IL6 TNF
13
NF-KappaB Family Pathway 60
Show member pathways
 12.81 CD40LG IL2 IL6 TGFB1 TLR4 TNF
14
Allograft rejection 1 37
Show member pathways
 12.81 CD40LG CXCL8 IFNG IL10 IL2 IL2RA
15
Immune response NFAT in immune response 21
Show member pathways
 12.78 CD40LG IFNG IL10 IL2 IL2RA IL4
16
PI3K-Akt signaling pathway 37
12.67 IL2 IL2RA IL4 IL6 TLR4
17
Immune response IL-23 signaling pathway 21
Show member pathways
 12.67 IFNG IL10 IL2 IL6 TNF
18
NF-kappaB Signaling 4
12.67 CD40LG IFNG IL10 IL1RN IL2 IL2RA
19
Th17 cell differentiation 37
Show member pathways
 12.65 IFNG IL10 IL2 IL2RA IL4 IL6
20
T cell receptor signaling pathway 37
Show member pathways
 12.55 CD40LG IFNG IL10 IL2 IL4 IL6
21
Immune response Role of DAP12 receptors in NK cells 21
Show member pathways
 12.54 IFNG IL2 IL4 TNF
22
HTLV-I infection 37
12.54 IL2 IL2RA IL6 TGFB1 TNF
23
Folate Metabolism 1
Show member pathways
 12.5 CRP IFNG IL2 IL4 IL6 TNF
24
IL-17 Family Signaling Pathways 61
Show member pathways
 12.45 CXCL8 IFNG IL4 IL6 TNF
25
Toll Comparative Pathway 60
Show member pathways
 12.41 CXCL8 IFNG IL6 TLR4 TNF
26
Toxoplasmosis 37
Show member pathways
 12.41 CD40LG IFNG IL10 IL4 TGFB1 TLR4
27
Tuberculosis 37
12.39 IFNG IL10 IL6 TGFB1 TLR4 TNF
28
Jak-STAT signaling pathway (KEGG) 37
Show member pathways
 12.37 IFNG IL10 IL2 IL2RA IL4 IL6
29
Bacterial infections in CF airways 21
Show member pathways
 12.35 CXCL8 IFNG IL4 IL6 TLR4 TNF
30
Diseases associated with the TLR signaling cascade 62
Show member pathways
 12.33 CXCL8 IL6 TLR4 TNF
31
Colorectal Cancer Metastasis 60
12.33 IFNG IL6 TGFB1 TLR4 TNF
32
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.32 CXCL8 IL10 IL1RN IL6 TNF
33
Immune response IFN alpha/beta signaling pathway 21
Show member pathways
 12.28 CXCL8 IFNG IL10 IL2 IL4 IL6
34
Interleukin-4 and 13 signaling 62
12.16 CXCL8 IL10 IL4 IL6 TGFB1 TNF
35
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 61
12.12 IFNG IL10 IL2 IL2RA IL4 IL6
36
Th17 Differentiation Pathway 61
Show member pathways
 12.1 IFNG IL4 IL6 TGFB1 TLR4
37
IL12-mediated signaling events 1
Show member pathways
 12.09 IFNG IL2 IL2RA IL4
38
Senescence and Autophagy in Cancer 1
12.06 CXCL8 IFNG IL6 TGFB1
39
IL27-mediated signaling events 1
Show member pathways
 12.05 IFNG IL10 IL2 IL6 TGFB1 TLR4
40
Rheumatoid arthritis 37
12.04 CXCL8 IFNG IL6 TGFB1 TLR4 TNF
41
AGE-RAGE signaling pathway in diabetic complications 37
12.03 CXCL8 IL6 TGFB1 TNF
42
Hematopoietic cell lineage 37
12.02 IL2RA IL4 IL6 TNF
43
NF-kappa B signaling pathway 37
12.01 CD40LG CXCL8 TLR4 TNF
44
Corticotropin-releasing hormone signaling pathway 1
12 CXCL8 IL2 TGFB1 TLR4
45
Cytokine production by Th17 cells in CF (Mouse model) 21
Show member pathways
 12 CXCL8 IL6 TGFB1 TLR4
46
Glucocorticoid receptor regulatory network 1
11.98 CXCL8 IFNG IL2 IL4 IL6
47
Salmonella infection (KEGG) 37
11.96 CXCL8 IFNG IL6 TLR4
48
Innate Lymphoid Cell Differentiation Pathways 61
11.96 IFNG IL10 IL2 IL2RA IL4 TNF
49
Amoebiasis 37
11.96 CXCL8 IFNG IL10 IL6 TGFB1 TLR4
50
Pertussis 37
11.94 CXCL8 IL10 IL6 TLR4 TNF
Sources

GO Terms for Brucellosis

About this section

Cellular components related to Brucellosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 CD40LG CRP CXCL8 IFNG IL10 IL1RN
2 intracellular GO:0005622 9.87 CD40LG CXCL8 IL1RN IL2 IL2RA MEFV
3 cell surface GO:0009986 9.65 CD40LG IL2RA TGFB1 TLR4 TNF
4 external side of plasma membrane GO:0009897 9.5 CD40LG IFNG IL2RA IL4 IL6 TLR4
5 extracellular space GO:0005615 9.36 CD40LG CRP CXCL8 IFNG IL10 IL1RN

Biological processes related to Brucellosis according to GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.97 IFNG IL2 IL4 TGFB1 TNF
2 positive regulation of gene expression GO:0010628 9.95 CRP IFNG IL6 SLC11A1 TGFB1 TLR4
3 response to organic substance GO:0010033 9.93 IL10 TGFB1 TNF
4 wound healing GO:0042060 9.93 IL6 SLC11A1 TGFB1
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.93 IL10 IL4 IL6 TNF
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.92 IL4 IL6 TGFB1
7 positive regulation of protein kinase B signaling GO:0051897 9.92 IL6 TGFB1 TNF
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.91 IL6 TGFB1 TNF
9 defense response to Gram-positive bacterium GO:0050830 9.91 CRP IL6 TNF
10 B cell differentiation GO:0030183 9.91 CD40LG IL10 IL4
11 negative regulation of inflammatory response GO:0050728 9.91 IL10 IL2 IL2RA MEFV
12 humoral immune response GO:0006959 9.89 IFNG IL6 TNF
13 defense response to Gram-negative bacterium GO:0050829 9.89 IL6 SLC11A1 TLR4
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 CD40LG IL6 TGFB1 TLR4 TNF
15 response to glucocorticoid GO:0051384 9.88 IL10 IL1RN IL6 TNF
16 negative regulation of fat cell differentiation GO:0045599 9.87 IL6 TGFB1 TNF
17 positive regulation of interleukin-6 production GO:0032755 9.87 IL6 TLR4 TNF
18 extrinsic apoptotic signaling pathway GO:0097191 9.87 IFNG TGFB1 TNF
19 positive regulation of B cell proliferation GO:0030890 9.87 IL2 IL4 TLR4
20 negative regulation of T cell proliferation GO:0042130 9.86 IL10 IL2RA TGFB1
21 response to bacterium GO:0009617 9.85 IL6 SLC11A1 TLR4
22 cellular response to lipopolysaccharide GO:0071222 9.85 CXCL8 IFNG IL10 IL6 TLR4 TNF
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.84 TGFB1 TLR4 TNF
24 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 IFNG IL2 IL4 IL6
25 protein import into nucleus, translocation GO:0000060 9.83 IFNG TGFB1 TNF
26 negative regulation of mitotic cell cycle GO:0045930 9.83 IL10 TGFB1 TNF
27 positive regulation of activated T cell proliferation GO:0042104 9.82 IL2 IL2RA IL4
28 negative regulation of interleukin-6 production GO:0032715 9.82 IL10 TLR4 TNF
29 positive regulation of interleukin-12 production GO:0032735 9.81 CD40LG IFNG TLR4
30 positive regulation of interferon-gamma production GO:0032729 9.81 IL2 SLC11A1 TLR4 TNF
31 positive regulation of protein complex assembly GO:0031334 9.8 IFNG TGFB1 TNF
32 positive regulation of interleukin-10 production GO:0032733 9.8 CD40LG IL4 TLR4
33 positive regulation of T cell differentiation GO:0045582 9.79 IL2 IL2RA IL4
34 positive regulation of nitric oxide biosynthetic process GO:0045429 9.78 IFNG IL6 TLR4 TNF
35 positive regulation of chemokine production GO:0032722 9.77 IL6 TLR4 TNF
36 negative regulation of growth of symbiont in host GO:0044130 9.77 IFNG IL10 TNF
37 cellular response to hepatocyte growth factor stimulus GO:0035729 9.76 IL10 IL6
38 negative regulation of immune response GO:0050777 9.76 IL2RA TGFB1
39 negative regulation of nitric oxide biosynthetic process GO:0045019 9.76 IL10 IL4
40 response to molecule of bacterial origin GO:0002237 9.76 CXCL8 IL10
41 positive regulation of interleukin-17 production GO:0032740 9.76 IL2 TGFB1
42 negative regulation of interleukin-12 production GO:0032695 9.75 IL10 MEFV
43 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.75 IL10 TNF
44 positive regulation of immunoglobulin secretion GO:0051024 9.75 IL2 IL6
45 positive regulation of protein import into nucleus, translocation GO:0033160 9.75 IFNG IL6
46 negative regulation of interleukin-17 production GO:0032700 9.75 IFNG TGFB1 TLR4
47 positive regulation of regulatory T cell differentiation GO:0045591 9.74 IL2 TGFB1
48 macrophage activation GO:0042116 9.74 SLC11A1 TLR4
49 positive regulation of superoxide anion generation GO:0032930 9.74 CRP TGFB1
50 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.74 IL10 IL1RN

Molecular functions related to Brucellosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 IL10 IL2 IL4 IL6 TGFB1
2 cytokine activity GO:0005125 9.32 CD40LG CXCL8 IFNG IL10 IL1RN IL2
Sources

Sources for Brucellosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO