Search: 
MCID: BRC012
MIFTS: 52

Brucellosis malady

Infectious category
7 symptoms, 54 genes, 127 related diseases, clinical trials.

Summaries for Brucellosis

about this section
Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A primary bacterial infectious disease that is caused by the bacteria of the genus brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. the disease has symptom fever, has symptom sweat, has symptom headache, has symptom back pain, has symptom physical weakness, has symptom joint pain and has symptom fatigue.

MalaCards: Brucellosis, also known as undulant fever, is related to tuberculosis and arthritis, and has symptoms including fever, sweat and headache. An important gene associated with Brucellosis is SAA1 (serum amyloid A1), and among its related pathways are Primary immunodeficiency and C-MYB transcription factor network. The compounds alpha-naphthyl butyrate and colchicine have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and immune system.

CDC:3 Brucellosis is an infectious disease caused by bacteria.

Wikipedia:64 Brucellosis, also called Bang\'s disease, Crimean fever, Gibraltar fever, Malta fever, Maltese fever,... more...

Aliases & Classifications for Brucellosis

about this section
Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
ICD10: 26 25


Aliases & Descriptions:

brucellosis 8 43 10 45 49 61
undulant fever 8 43
gibraltar fever 43
maltese fever 8
cyprus fever 43
malta fever 43
rock fever 43


External Ids:

Disease Ontology8 DOID:11077
ICD9CM27 023.9, 023
NCIt40 C84602
MESH via Orphanet36 D002006
ICD10 via Orphanet26 A23
SNOMED-CT via Orphanet58 75702008
UMLS via Orphanet62 C0006309

Related Diseases for Brucellosis

about this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Brucellosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.5LYZ, ADA, BLZF1, SLC11A1
2arthritis30.1FCGR2A, ANPEP, TAP2, MEFV, SLC11A1, PSMB9
3hepatitis c29.8TAP2
4vasculitis29.8BLZF1, CD14, MEFV
5acute leukemia29.8CD14, BLZF1, ANPEP
6deficiency anemia29.8SAA1, FCGR2A, SLC11A1
7brucella melitensis brucellosis10.5
8brucella abortus brucellosis10.5
9pancytopenia10.4
10leptospirosis10.4
11orchitis10.4
12brucella canis brucellosis10.3
13brucella suis brucellosis10.3
14epidural abscess10.3
15thrombocytopenia10.3
16splenic abscess10.2
17tick-borne relapsing fever10.1
18rhinotracheitis10.1
19autoimmune hemolytic anemia10.1
20hepatitis b10.1
21toxoplasmosis10.1
22myelitis10.0
23thrombotic thrombocytopenic purpura10.0
24capillary leak syndrome10.0
25tularemia10.0
26hepatitis10.0ANPEP
27crohn's disease10.0LYZ
28ulcerative colitis10.0LYZ
29celiac disease10.0MICA
30familial mediterranean fever10.0SAA1, MEFV
31alzheimer's disease10.0BLZF1
32intestinal tuberculosis10.0PSMB9
33amyloidosis10.0LYZ, MEFV, SAA1
34diabetes mellitus10.0TAP1, CD14
35cervical cancer10.0TAP2, TAP1
36psoriasis10.0TAP1, TAP2
37mastitis10.0LYZ
38pleurisy10.0MEFV, ADA
39malaria10.0SLC11A1, FCGR2A
40neutropenia10.0BLZF1, ANPEP
41sjogren's syndrome10.0TAP1, TAP2
42myeloma10.0BLZF1, CD14, ANPEP
43amyloidosis, renal10.0SAA1, MEFV
44bronchiectasis10.0TAP2
45nephrotic syndrome10.0CD14
46myeloid leukemia10.0ANPEP, CD14
47prostate cancer10.0ANPEP, BLZF1
48adenocarcinoma10.0ANPEP, ADA, BLZF1
49amyloidosis, secondary10.0MEFV, SAA1
50ankylosing spondylitis10.0TAP2, PSMB9, TAP1

Graphical network of the top 20 diseases related to Brucellosis:



Diseases related to brucellosis

Clinical Features for Brucellosis

about this section
Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 7)
  • fever
  • sweat
  • headache
  • back pain
  • physical weakness
  • joint pain
  • fatigue

Drugs & Therapeutics for Brucellosis

about this section
Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Brucellosis

Drug clinical trials:

Search ClinicalTrials for Brucellosis

Search NIH Clinical Center for Brucellosis

Search CenterWatch for Brucellosis

Genetic Tests for Brucellosis

about this section

Anatomical Context for Brucellosis

about this section

Animal Models for Brucellosis or affiliated genes

about this section
Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Brucellosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
hematopoietic system phenotype
MP:00053979.8PSMB9, MEFV, ANPEP, TAP1, TAP2, FCGR2A
2
immune system phenotype
MP:00053879.4ADA, PSMB8, PSMB9, MEFV, ANPEP, CD14

Publications for Brucellosis

about this section
Sources:
51PubMed
See all sources

Articles related to Brucellosis:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
Seroepidemiological survey of q Fever and brucellosis in kurdistan province, Western iran. (24359427)
2014
2
Herd-level risk factors for Campylobacter fetus infection, Brucella seropositivity and within-herd seroprevalence of brucellosis in cattle in northern Nigeria. (23830113)
2013
3
Prevalence and risk factors for brucellosis in goats in areas of Mexico with and without brucellosis control campaign. (23420068)
2013
4
Epidemiological, laboratory, diagnostic and public health aspects of human brucellosis in western Iran. (23905014)
2013
5
An electrophysiological study of peripheral polyneuropathy in brucellosis. (23906248)
2013
6
Seroprevalence of brucellosis in livestock within three endemic regions of the country of Georgia. (23287714)
2013
7
A "One Health" surveillance and control of brucellosis in developing countries: moving away from improvisation. (23044181)
2013
8
Pregnancy associated brucellosis. (22812618)
2013
9
Knowledge and practices related to bovine brucellosis transmission amongst livestock workers in Yewa, south-western Nigeria. (23718254)
2013
10
Evaluation of four hundred and forty seven brucellosis cases. (23545668)
2013
11
Prevalence and risk-mapping of bovine brucellosis in MaranhALo State, Brazil. (23218657)
2013
12
Could thrombocyte parameters be an inflammatory marker in the brucellosis? (23348158)
2013
13
Serological evidence of brucellosis in goats in kaduna north senatorial district of kaduna state, Nigeria. (23762594)
2013
14
Clinical presentations and diagnosis of brucellosis. (22873352)
2013
15
Brucellosis disguised as infective endocarditis in the returning traveller. (23476733)
2013
16
Epidemiosurveillance of brucellosis. (23837377)
2013
17
Trends of human brucellosis in Italy, 1998-2010. (24044411)
2013
18
Outcomes of treatment in 50 cases with spinal brucellosis in Babol, Northern Iran. (23000864)
2012
19
Brucellosis laboratory tests in Syria: what are their diagnostic efficacies in different clinical manifestations? (22706192)
2012
20
A case of brucellosis complicated with fatal capillary leak syndrome. (22897381)
2012
21
Yersinia enterocolitica: an unlikely cause of positive brucellosis tests in greater yellowstone ecosystem bison (Bison bison). (22740518)
2012
22
Brucellosis in camels. (21632084)
2012
23
Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development. (22919593)
2012
24
Comment on: Epidemiologic, Clinical and Laboratory Findings of Patients with Brucellosis in Hamadan, West of Iran. (23772010)
2012
25
Brucellosis due to Brucella suis in a swine herd associated with a human clinical case in the State of SALo Paulo, Brazil. (22388711)
2012
26
Brucellosis in Turkey -- an overview. (22333223)
2012
27
Brucellosis control in Tajikistan using Rev 1 vaccine: change in seroprevalence in small ruminants from 2004 to 2009. (22121155)
2012
28
Control and prevention of brucellosis in small ruminants: time for action. (22287394)
2012
29
Brucellosis of the European brown hare (Lepus europaeus). (21511271)
2011
30
Confronting the barriers to develop novel vaccines against brucellosis. (21919619)
2011
31
Cell-mediated immunity in human brucellosis. (21034846)
2011
32
Medulloblastoma and Brucellosis - Molecular Evidence of Brucella sp in Association with Central Nervous System Cancer. (21475718)
2011
33
Polymerase chain reaction (PCR) assay for rapid diagnosis and its role in prevention of human brucellosis in Punjab, India. (21811660)
2011
34
Evaluation of the recombinant 10-kilodalton immunodominant region of the BP26 protein of Brucella abortus for specific diagnosis of bovine brucellosis. (21852548)
2011
35
Spontaneous splenic rupture with hematoma in a patient with brucellosis. (22490460)
2011
36
Brucellosis, presenting with guillain-barrAc syndrome. (22224005)
2011
37
Protective live oral brucellosis vaccines stimulate Th1 and th17 cell responses. (21768283)
2011
38
The feasibility of using antigens prepared with rough Brucella strains for diagnosis of canine brucellosis. (20461292)
2010
39
Utility of bone marrow culture in the definitive diagnosis of human brucellosis. (22471179)
2010
40
Comparative study of the immunobiological properties of live brucellosis vaccines. (20362201)
2010
41
Transforming growth factor beta production correlates with depressed lymphocytes function in humans with chronic brucellosis. (19665058)
2009
42
Seroprevalence of Q fever, brucellosis and leptospirosis in farmers and agricultural workers in Bari, Southern Italy. (20047252)
2009
43
Epididymoorchitis and pancytopenia caused by brucellosis. (17921561)
2007
44
Serum cytokine levels in patients with acute brucellosis and their relation to the traditional inflammatory markers. (14625098)
2003
45
Frequency analysis of the CCR5delta32 mutation in patients with brucellosis. (12587636)
2002
46
Increased pleural fluid adenosine deaminase in brucellosis is difficult to differentiate from tuberculosis. (12457012)
2002
47
Bilateral dacryoadenitis associated with brucellosis. (10406164)
1999
48
Bilateral papilledema in a patient with brucellosis. (2079902)
1990
49
Epididymo-orchitis and Brucellosis. (2920268)
1989
50
Brucellosis and miliary tuberculosis in an Eskimo woman. (13231022)
1955

Genetic Variations for Brucellosis

about this section

Expression for genes affiliated with Brucellosis

about this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Brucellosis

Search GEO for disease gene expression data for Brucellosis.

Pathways for genes affiliated with Brucellosis

about this section
Sources:
30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome
See all sources

Pathways related to Brucellosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Primary immunodeficiency30
10.3ADA, TAP1
2
C-MYB transcription factor network38
10.2LYZ, ADA, ANPEP
3
Immune response Antigen presentation by MHC class I12
10.2PSMB8, PSMB9, TAP1, TAP2
4
Antigen processing: Ubiquitination & Proteasome degradation54
Hide members
10.2TAP2, TAP1, PSMB9, PSMB8
5
Phagosome30
10.2TAP2, FCGR2A, TAP1, CD14
6
Disease54
10.1SAA1, PSMB8, PSMB9, SLC11A1, LYZ
7
Immune System54
Hide members
9.9SAA1, TAP2, TAP1, CD14, MICA, MEFV

Compounds for genes affiliated with Brucellosis

about this section
Sources:
45Novoseek, 60Tocris Bioscience, 2BitterDB, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Brucellosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alpha-naphthyl butyrate4510.5CD14, ANPEP
2colchicine60 45 2 29 1114.3ANPEP, MEFV, SAA1
3glutamine4510.2ADA, FCGR2A, TAP2, TAP1, CD14, BLZF1
4sucrose45 11 2412.2ANPEP, BLZF1, CD14, LYZ
5alanine4510.1SAA1, ANPEP, BLZF1, CD14, TAP1, TAP2
6arginine4510.1SAA1, ANPEP, BLZF1, CD14, FCGR2A, ADA
7atp45 2911.1ANPEP, BLZF1, CD14, TAP1, TAP2, FCGR2A
8oligonucleotide4510.1FCGR2A, TAP2, TAP1, CD14, ANPEP
9tuberculin4510.0ADA, CD14
10cholesterol45 29 11 2413.0SAA1, ANPEP, BLZF1, CD14, FCGR2A

GO Terms for genes affiliated with Brucellosis

about this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Brucellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:04282510.3TAP1, TAP2
2spermatoproteasome complexGO:199011110.2PSMB8, PSMB9
3cell surfaceGO:00998610.1MICA, CD14, ADA, SYNJ2BP
4proteasome core complexGO:00583910.0PSMB9, PSMB8

Biological processes related to Brucellosis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.5TAP2, TAP1
2intracellular transport of viral proteins in host cellGO:01906010.5TAP2, TAP1
3negative regulation of inflammatory responseGO:05072810.4SAA1, MEFV, ADA
4peptide transportGO:01583310.4TAP2, TAP1
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.4TAP2, TAP1, PSMB9, PSMB8
6antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259010.4PSMB8, PSMB9, TAP1, TAP2
7antigen processing and presentation of peptide antigen via MHC class IGO:00247410.4PSMB8, PSMB9, TAP1, TAP2
8antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.4TAP2, TAP1
9cytolysisGO:01983510.3LYZ, MICA
10inflammatory responseGO:00695410.2MEFV, CD14, SLC11A1, LYZ
11defense response to bacteriumGO:04274210.1MICA, SLC11A1, LYZ
12modulation by virus of host morphology or physiologyGO:0190489.8MICA, ANPEP, PSMB9, PSMB8

Molecular functions related to Brucellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide transporter activityGO:01519710.4TAP2, TAP1
2tapasin bindingGO:04698010.4TAP2, TAP1
3TAP2 bindingGO:04697910.3TAP1, TAP2
4MHC class I protein bindingGO:04228810.3TAP2, TAP1
5TAP1 bindingGO:04697810.2TAP1, TAP2
6oligopeptide-transporting ATPase activityGO:01542110.0TAP1, TAP2

Products for genes affiliated with Brucellosis

about this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brucellosis

about this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
Browse MalaCards: 1-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z