MCID: BRC012
MIFTS: 63

Brucellosis malady

Infectious diseases category

Summaries for Brucellosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that is caused by the bacteria of the genus brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. the disease has symptom fever, has symptom sweat, has symptom headache, has symptom back pain, has symptom physical weakness, has symptom joint pain and has symptom fatigue.

MalaCards: Brucellosis, also known as undulant fever, is related to tuberculosis and hepatitis, and has symptoms including fatigue, joint pain and physical weakness. An important gene associated with Brucellosis is SAA1 (serum amyloid A1), and among its related pathways are Primary immunodeficiency and C-MYB transcription factor network. The compounds alpha-naphthyl butyrate and colchicine have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and t cells, and related mouse phenotypes are hematopoietic system and immune system.

CDC:3 Brucellosis is an infectious disease caused by bacteria.

Wikipedia:63 Brucellosis, also called Bang\'s disease, Crimean fever, Gibraltar fever, Malta fever, Maltese fever,... more...

Aliases & Classifications for Brucellosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

brucellosis 8 42 10 44 48 60
undulant fever 8 42
gibraltar fever 42
maltese fever 8
cyprus fever 42
malta fever 42
rock fever 42


External Ids:

Disease Ontology8 DOID:11077
ICD9CM27 023.9, 023
NCIt39 C84602
MESH via Orphanet35 D002006
SNOMED-CT via Orphanet57 75702008
ICD10 via Orphanet26 A23.0, A23.1, A23.2 A23.3, A23.8, A23.9, more
UMLS via Orphanet61 C0006309

Related Diseases for Brucellosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Brucellosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.5BLZF1, SLC11A1, ADA, LYZ
2hepatitis30.3ANPEP
3arthritis30.1SAA1, PSMB9, MEFV, ANPEP, TAP2, FCGR2A
4meningitis29.9LYZ, ADA, FCGR2A
5hepatitis c29.7TAP2
6vasculitis29.7MEFV, BLZF1, CD14
7acute leukemia29.7ANPEP, BLZF1, CD14
8deficiency anemia29.7SAA1, FCGR2A, SLC11A1
9leukemia29.7PSMB8, ANPEP, BLZF1, CD14, TAP1, TAP2
10brucella melitensis brucellosis10.4
11brucella abortus brucellosis10.4
12pancytopenia10.4
13leptospirosis10.3
14orchitis10.3
15q fever10.3
16brucella canis brucellosis10.3
17epididymo-orchitis10.3
18brucella suis brucellosis10.3
19epidural abscess10.2
20thrombocytopenia10.2
21endocarditis10.2
22hemolytic anemia10.2
23splenic abscess10.1
24cervicitis10.1
25purpura10.1
26tick-borne relapsing fever10.1
27relapsing fever10.1
28rhinotracheitis10.1
29autoimmune hemolytic anemia10.1
30extrapulmonary tuberculosis10.1
31toxoplasmosis10.1
32crohn's disease10.0LYZ
33ulcerative colitis10.0LYZ
34celiac disease10.0MICA
35familial mediterranean fever10.0MEFV, SAA1
36alzheimer's disease10.0BLZF1
37intestinal tuberculosis10.0PSMB9
38myelitis10.0
39thrombotic thrombocytopenic purpura10.0
40capillary leak syndrome10.0
41cholestasis10.0
42glomerulonephritis10.0
43infective endocarditis10.0
44myositis10.0
45panniculitis10.0
46pericardial effusion10.0
47polyneuropathy10.0
48tularemia10.0
49amyloidosis10.0SAA1, MEFV, LYZ
50diabetes mellitus10.0TAP1, CD14

Graphical network of the top 20 diseases related to Brucellosis:



Diseases related to brucellosis

Clinical Features for Brucellosis

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 7)
  • fatigue
  • joint pain
  • physical weakness
  • back pain
  • headache
  • sweat
  • fever

Drugs & Therapeutics for Brucellosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Brucellosis

Drug clinical trials:

Search ClinicalTrials for Brucellosis

Search NIH Clinical Center for Brucellosis

Search CenterWatch for Brucellosis

Genetic Tests for Brucellosis

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Anatomical Context for Brucellosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Brucellosis:

32
Testes, Liver, T cells, Bone, Bone marrow, Skin, Breast, Prostate, Testis, Monocytes, Pons, Spinal cord, Whole blood

Animal Models for Brucellosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Brucellosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.8PSMB9, MEFV, ANPEP, TAP1, TAP2, FCGR2A
2MP:00053879.4ADA, PSMB8, PSMB9, MEFV, ANPEP, CD14

Publications for Brucellosis

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Sources:
50PubMed
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Articles related to Brucellosis:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
Splenic abscess due to brucellosis: a case report and a review of the literature. (24433982)
2014
2
Human Brucellosis in Northwest Ecuador: Typifying Brucella spp., Seroprevalence, and Associated Risk Factors. (24410144)
2014
3
Severe persistent thrombocytopenia as a sole manifestation of brucellosis. (22544672)
2013
4
Evidence of bovine viral diarrhea, but absence of infectious bovine rhinotracheitis and bovine brucellosis in the endangered huemul deer (Hippocamelus bisulcus) in Chilean Patagonia. (23778636)
2013
5
Developing a real-time quantitative loop-mediated isothermal amplification assay as a rapid and accurate method for detection of Brucellosis. (23795718)
2013
6
Brucellosis in a renal transplant recipient. (24034171)
2013
7
Recent developments in livestock and wildlife brucellosis vaccination. (23837378)
2013
8
Update on childhood brucellosis. (22812616)
2013
9
Levels of interleukin-(IL)-12p40 are markedly increased in Brucellosis among patients with specific IL-12B genotypes. (23578145)
2013
10
Transmission of brucellosis from elk to cattle and bison, Greater Yellowstone area, U.S.A., 2002-2012. (24274092)
2013
11
Persistence of brucellosis in pastoral systems. (23837365)
2013
12
An infant with acute brucellosis presenting with coombs-positive autoimmune hemolytic anemia: is breastfeeding guilty for transmission? (23560724)
2013
13
Brucellosis in pastoral and confined livestock: prevention and vaccination. (23837379)
2013
14
Splenic abcess owing to brucellosis. (23625669)
2013
15
Brucellosis: 'One Health' challenges and opportunities. (23837384)
2013
16
Preliminary study of an immunochromatography test for serological diagnosis of canine brucellosis. (23279541)
2012
17
Human brucellosis outbreak acquired through camel milk ingestion in southern Israel. (22977965)
2012
18
DRESS syndrome with fatal results induced by sodium valproate in a patient with brucellosis and a positive cytoplasmic antineutrophilic cytoplasmic antibody test result. (20354855)
2012
19
Buffalo, bush meat, and the zoonotic threat of brucellosis in Botswana. (22412932)
2012
20
Brucellosis and type IV secretion. (22191446)
2012
21
Brucellosis in takins, China. (22931790)
2012
22
Comparison of total antibody and interferon-I^ T-cell responses in patients following infection with brucellosis in Georgia. (23164560)
2012
23
Doxycycline-rifampin versus doxycycline-rifampin-gentamicin in treatment of human brucellosis. (22290107)
2012
24
Acute brucellosis with myelodysplastic syndrome presenting as pancytopenia and Fever of unknown origin. (22133749)
2012
25
Neonatal brucellosis and breast milk. (21993699)
2012
26
An evaluation of the capability of existing and novel serodiagnostic methods for porcine brucellosis to reduce false positive serological reactions. (22763172)
2012
27
Cattle producers' economic incentives for preventing bovine brucellosis under uncertainty. (22795545)
2012
28
Seroprevalance of brucellosis among suspected cases in Malaysia. (21874749)
2011
29
Case report on the development of a brucellosis-related epidural abscess. (21628820)
2011
30
Seroprevalence of ovine brucellosis in south Wollo, north eastern Ethiopia. (22066286)
2011
31
Outcomes of 19 pregnant women with brucellosis in Babol, northern Iran. (21742362)
2011
32
The Rose Bengal Test in human brucellosis: a neglected test for the diagnosis of a neglected disease. (21526218)
2011
33
Ruminant brucellosis in Upper Egypt (2005-2008). (21684026)
2011
34
Implications of laboratory diagnosis on brucellosis therapy. (21810055)
2011
35
Musculoskeletal brucellosis. (22081282)
2011
36
Comparison of a novel immunocapture assay with standard serological methods in the diagnosis of brucellosis. (21755823)
2011
37
Unusual manifestations of brucellosis. (22291753)
2011
38
An unusual manifestation of brucellosis infection: acute renal failure. (20540645)
2010
39
Brucellosis infection presenting with cholestasis. (20579915)
2010
40
Brucellosis - regionally emerging zoonotic disease? (20718081)
2010
41
Brucellosis in a high risk occupational group: seroprevalence and analysis of risk factors. (21381558)
2010
42
Brucellosis control in small ruminants in the Republic of Macedonia. (20703191)
2010
43
A case of brucellosis with abscess of the iliacus muscle, olecranon bursitis, and sacroiliitis. (19398360)
2009
44
Assessment of diagnostic enzyme-linked immunosorbent assay kit and serological markers in human brucellosis. (18806343)
2008
45
Th-1 cytokines gene polymorphism in human brucellosis. (16984280)
2006
46
Interleukin-3 and interleukin-4 in childhood brucellosis. (11876513)
2002
47
Limited diagnostic usefulness of antibodies to cytoplasmic proteins of Brucella in early-treated human brucellosis. (11303810)
2001
48
Granulomatous epididymo-orchitis: sonographic features and clinical outcome in brucellosis, tuberculosis and idiopathic granulomatous epididymo-orchitis. (9598496)
1998
49
Brucellosis induced avascular necrosis of the femoral head in a 7 year old child. (1575594)
1992
50
Effect of atrophic rhinitis vaccines on the reaction of pigs to serological tests for brucellosis. (4049708)
1985

Genetic Variations for Brucellosis

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Expression for genes affiliated with Brucellosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Brucellosis

Search GEO for disease gene expression data for Brucellosis.

Pathways for genes affiliated with Brucellosis

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Brucellosis

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Sources:
44Novoseek, 59Tocris Bioscience, 2BitterDB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Brucellosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1alpha-naphthyl butyrate4410.5CD14, ANPEP
2colchicine59 44 2 28 1114.3ANPEP, MEFV, SAA1
3glutamine4410.2ADA, FCGR2A, TAP2, TAP1, CD14, BLZF1
4sucrose44 11 2412.2ANPEP, BLZF1, CD14, LYZ
5alanine4410.1SAA1, ANPEP, BLZF1, CD14, TAP1, TAP2
6arginine4410.1SAA1, ANPEP, BLZF1, CD14, FCGR2A, ADA
7atp44 2811.1ANPEP, BLZF1, CD14, TAP1, TAP2, FCGR2A
8oligonucleotide4410.1FCGR2A, TAP2, TAP1, CD14, ANPEP
9tuberculin4410.0ADA, CD14
10cholesterol44 28 11 2413.0SAA1, ANPEP, BLZF1, CD14, FCGR2A

GO Terms for genes affiliated with Brucellosis

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16Gene Ontology
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Cellular components related to Brucellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP complexGO:04282510.3TAP2, TAP1
2spermatoproteasome complexGO:199011110.2PSMB9, PSMB8
3cell surfaceGO:00998610.1ADA, CD14, MICA, SYNJ2BP
4proteasome core complexGO:00583910.0PSMB8, PSMB9

Biological processes related to Brucellosis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cytosol to ER transportGO:04696710.5TAP2, TAP1
2intracellular transport of viral proteins in host cellGO:01906010.5TAP2, TAP1
3negative regulation of inflammatory responseGO:05072810.4SAA1, MEFV, ADA
4peptide transportGO:01583310.4TAP2, TAP1
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.4TAP2, TAP1, PSMB9, PSMB8
6antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259010.4PSMB8, PSMB9, TAP1, TAP2
7antigen processing and presentation of peptide antigen via MHC class IGO:00247410.4PSMB8, PSMB9, TAP1, TAP2
8antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.4TAP2, TAP1
9cytolysisGO:01983510.3LYZ, MICA
10inflammatory responseGO:00695410.2MEFV, CD14, SLC11A1, LYZ
11defense response to bacteriumGO:04274210.1MICA, SLC11A1, LYZ
12modulation by virus of host morphology or physiologyGO:0190489.8MICA, ANPEP, PSMB9, PSMB8

Molecular functions related to Brucellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide transporter activityGO:01519710.4TAP2, TAP1
2tapasin bindingGO:04698010.4TAP2, TAP1
3TAP2 bindingGO:04697910.3TAP1, TAP2
4MHC class I protein bindingGO:04228810.3TAP2, TAP1
5TAP1 bindingGO:04697810.2TAP1, TAP2
6oligopeptide-transporting ATPase activityGO:01542110.0TAP1, TAP2

Products for genes affiliated with Brucellosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Brucellosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet