Brucellosis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Brucellosis

Sources:
⁹Disease Ontology, ⁶⁴Wikipedia, ³²MalaCards
See all sources

Disease Ontology:⁹ A primary bacterial infectious disease that is caused by the bacteria of the genus brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. the disease has symptom fever, has symptom sweat, has symptom headache, has symptom back pain, has symptom physical weakness, has symptom joint pain and has symptom fatigue.

MalaCards based summary: Brucellosis, also known as undulant fever, is related to vasculitis and arthritis, and has symptoms including fever, sweat and headache. An important gene associated with Brucellosis is MEFV (Mediterranean fever), and among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Presenilin-Mediated Signaling. The compounds colchicine and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and bone marrow, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:⁶⁴ Brucellosis, also called Bang\'s disease, Crimean fever, Gibraltar fever, Malta fever, Maltese fever,... more...

Aliases & Classifications for Brucellosis

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ¹¹DISEASES, ⁴⁴Novoseek, ⁴⁸Orphanet, ⁶¹UMLS, ⁵⁶SNOMED-CT, ²⁸ICD9CM, ³⁴MeSH, ³⁹NCIt, ³⁵MESH via Orphanet, ²⁷ICD10 via Orphanet, ⁶²UMLS via Orphanet, ²⁶ICD10
See all sources

Brucellosis, Aliases & Descriptions:

Name: Brucellosis ⁹ ⁴² ¹¹ ⁴⁴ ⁴⁸ ⁶¹

Undulant Fever ⁹ ⁴² ⁶¹

Gibraltar Fever ⁴² ⁶¹

Cyprus Fever ⁴² ⁶¹

Maltese Fever ⁹

Malta Fever ⁴²

Rock Fever ⁴²

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases

ICD10: ²⁷ ²⁶

Certain infectious and parasitic diseases

Certain zoonotic bacterial diseases

Brucellosis

Brucellosis due to Brucella melitensis

Brucellosis due to Brucella abortus

Brucellosis due to Brucella suis

Brucellosis due to Brucella canis

Brucellosis, unspecified

Orphanet: ⁴⁸

Rare infectious diseases

External Ids:

Disease Ontology⁹ DOID:11077

ICD9CM²⁸ 023, 023.9

MeSH³⁴ C531637, D002006

NCIt³⁹ C84602

SNOMED-CT⁵⁶ 111804008, 186310006, 154296006 187304000, 75702008, more

MESH via Orphanet³⁵ D002006

ICD10 via Orphanet²⁷ A23.0, A23.1, A23.2 A23.3, A23.8, A23.9, more

UMLS via Orphanet⁶² C0006309

ICD10²⁶ A23, A23.0 A23.1, A23.2, A23.3, A23.9, more

UMLS⁶¹ C0006309

Related Diseases for Brucellosis

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Brucellosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 129)

id	Related Disease	Score	Top Affiliating Genes
1	vasculitis	30.0	MEFV, CD14
2	arthritis	30.0	SLC11A1, MEFV, PSMB9, SAA1
3	pericarditis	29.9	ADA, MEFV
4	peritonitis	29.6	CD14, MEFV, ADA
5	intestinal tuberculosis	10.4	PSMB9
6	pancytopenia	10.4
7	tuberculosis	10.4
8	leptospirosis	10.4
9	orchitis	10.4
10	q fever	10.4
11	epididymo-orchitis	10.3
12	thrombocytopenia	10.3
13	hepatitis	10.3
14	epidural abscess	10.3
15	amyloidosis, renal	10.3	SAA1, MEFV
16	amyloidosis, secondary	10.2	SAA1, MEFV
17	hemolytic anemia	10.2
18	brucella melitensis brucellosis	10.2
19	endocarditis	10.2
20	familial mediterranean fever	10.2	MEFV, SAA1
21	amyloidosis	10.2	MEFV, SAA1
22	splenic abscess	10.2
23	cervicitis	10.2
24	purpura	10.2
25	tick-borne relapsing fever	10.2
26	relapsing fever	10.2
27	berger disease	10.1	CD14, MEFV
28	autoimmune thyroiditis	10.1	PSMB9, PSMB8
29	brucella canis brucellosis	10.1
30	brucella abortus brucellosis	10.1
31	autoimmune hemolytic anemia	10.1
32	rhinotracheitis	10.1
33	brucella suis brucellosis	10.1
34	extrapulmonary tuberculosis	10.1
35	toxoplasmosis	10.1
36	pleurisy	10.0	ADA, MEFV
37	behcet's disease	10.0	MEFV, ADA
38	graves' disease	10.0	PSMB8, PSMB9
39	type 1 diabetes mellitus	10.0	PSMB8, PSMB9
40	glomerulonephritis	10.0
41	capillary leak syndrome	10.0
42	myelitis	10.0
43	rift valley fever	10.0
44	thrombotic thrombocytopenic purpura	10.0
45	cholestasis	10.0
46	meningitis	10.0
47	myositis	10.0
48	panniculitis	10.0
49	pericardial effusion	10.0
50	polyneuropathy	10.0

Graphical network of the top 20 diseases related to Brucellosis:

Symptoms for Brucellosis

Sources:
⁹Disease Ontology
See all sources

Symptoms:

⁹ (show all 7)

fever
sweat
headache
back pain

physical weakness
joint pain
fatigue

Drugs & Therapeutics for Brucellosis

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Brucellosis

Search NIH Clinical Center for Brucellosis

Genetic Tests for Brucellosis

Anatomical Context for Brucellosis

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Brucellosis:

³²

Testes, Liver, Bone marrow, Bone, T cells, Skin, Whole blood, Spinal cord, Breast, Prostate, Testis, Monocytes, Pons, Neutrophil

Animal Models for Brucellosis or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Brucellosis:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	7.2	ADA, PSMB9, PSMB8, MEFV, CD14, SLC11A1
2	hematopoietic system phenotype	MP:0005397	6.9	ADA, PSMB9, PSMB8, MEFV, CD14, SLC11A1

Publications for Brucellosis

Sources:
⁵¹PubMed
See all sources

Articles related to Brucellosis:

(show top 50) (show all 597)

id	Title	Authors	Year
1	Transmission dynamics and control for a brucellosis model in Hinggan League of Inner Mongolia, China. (25347802)	Li M.... Zheng Y.	2014
2	Acute brucellosis with typical hemophagocytic lymphohistiocytosis accompanying elevated tumor markers. (25305773)	Yin X.... Chen S.	2014
3	EVALUATION OF THE SENSITIVITY AND SPECIFICITY OF AN ENZYME-LINKED IMMUNOSORBENT ASSAY FOR DIAGNOSING BRUCELLOSIS IN AFRICAN BUFFALO (SYNCERUS CAFFER). (25397998)	Gorsich E.E.... Jolles A.E.	2014
4	Herd-level risk factors for Campylobacter fetus infection, Brucella seropositivity and within-herd seroprevalence of brucellosis in cattle in northern Nigeria. (23830113)	Mai H.M.... Thompson P.N.	2013
5	Bayesian estimation of true prevalence, sensitivity and specificity of indirect ELISA, Rose Bengal Test and Slow Agglutination Test for the diagnosis of brucellosis in sheep and goats in Bangladesh. (23276401)	Rahman A.K.... Emmanuel A.	2013
6	Prevalence and risk factors for brucellosis in goats in areas of Mexico with and without brucellosis control campaign. (23420068)	Oseguera Montiel D.... van der Zijpp A.	2013
7	Human brucellosis, a heterogeneously distributed, delayed, and misdiagnosed disease in china. (23175566)	Wang Y.... Chen Z.	2013
8	New developments in the immunodiagnosis of brucellosis in livestock and wildlife. (23837374)	McGiven J.A.	2013
9	Time series analysis of human and bovine brucellosis in South Korea from 2005 to 2010. (23276400)	Lee H.S.... Moore G.E.	2013
10	Severe persistent thrombocytopenia as a sole manifestation of brucellosis. (22544672)	Sac R.... Tunc B.	2013
11	Host-Brucella interactions and the Brucella genome as tools for subunit antigen discovery and immunization against brucellosis. (23720712)	Gomez G.... Ficht T.A.	2013
12	Antibiotic susceptibility and treatment of brucellosis. (22812615)	Al-Tawfiq J.A.... Memish Z.A.	2013
13	Two-stage PCR assay for detection of human brucellosis in endemic areas. (23517532)	Kamal I.H.... Abulnaja K.O.	2013
14	Risk factors associated with brucellosis seropositivity among cattle in the central savannah-forest area of Ivory Coast. (22704904)	Sanogo M.... Saegerman C.	2012
15	Laboratory-acquired brucellosis in Turkey. (22365915)	Sayin-Kutlu S.... Akova M.	2012
16	Epidemiological and clinical aspects of human brucellosis in eastern Anatolia. (23123390)	Aypak C.... Kutta A8elik A.	2012
17	Estimation of sensitivity and specificity of five serological tests for the diagnosis of porcine brucellosis. (22153032)	Praud A.... Garin-Bastuji B.	2012
18	Brucellosis manifesting as chronic inflammatory demyelinating polyneuropathy. (22728867)	Kang B.H.... Kim K.K.	2012
19	Outcomes of treatment in 50 cases with spinal brucellosis in Babol, Northern Iran. (23000864)	Smailnejad Gangi S.M.... Khalilian E.	2012
20	Application of the microagglutination test for serologic diagnosis of human brucellosis. (24159482)	Park S.H.... Park M.Y.	2012
21	Brucellosis-induced avascular necrosis of the hip in a middle-aged person. (23641397)	Salarvand S.h.... Pournia Y.	2012
22	Osteoarticular manifestations of brucellosis. (22937686)	Mehanic S.... Hadziosmanovic V.	2012
23	Preliminary study of an immunochromatography test for serological diagnosis of canine brucellosis. (23279541)	Wanke M.M.... Vivot M.M.	2012
24	Brucellosis laboratory tests in Syria: what are their diagnostic efficacies in different clinical manifestations? (22706192)	Alsayed Y.... Monem F.	2012
25	Assessment of performance of selected serological tests for diagnosing brucellosis in pigs. (22445082)	MuA+oz P.M.... Mainar-Jaime R.C.	2012
26	Decreasing prevalence of brucellosis in red deer through efforts to control disease in livestock. (21676351)	Serrano E.... Marco I.	2011
27	Seroprevalence of Brucellosis among high risk individuals in Guilan, Iran. (22973333)	Nikokar I.... Razavei M.T.	2011
28	Seroprevalance of brucellosis among suspected cases in Malaysia. (21874749)	Jama'ayah M.Z.... Norazah A.	2011
29	Hepatic granulomas associated with brucellosis: Hepatic granulomas and brucellosis. (22087106)	Albayrak A.... Albayrak F.	2011
30	Lymphocyte activation test for diagnosis of seronegative brucellosis in humans. (22234109)	Almajid F.M.	2011
31	Brucellosis of the European brown hare (Lepus europaeus). (21511271)	Gyuranecz M.... Szeredi L.	2011
32	Pleural and pericardial effusions: rare presentations of brucellosis, Iran. (21713754)	Soudbakhsh A.... McFarland W.	2011
33	Pediatric brucellosis: an (almost) forgotten disease. (22125040)	Yagupsky P.	2011
34	Problems with the use of a lateral flow assay in the serodiagnosis of brucellosis. (22124267)	Eales K.... Norton R.	2011
35	Quantifying risk factors for human brucellosis in rural northern Tanzania. (20376363)	John K.... Cleaveland S.	2010
36	Superior mesenteric artery syndrome secondary to brucellosis - A case report. (23133263)	Prasad S.... Abdul Z.	2010
37	Brucellosis in northern Australia. (20889883)	Eales K.M.... Ketheesan N.	2010
38	Ovine and Caprine Brucellosis (Brucella melitensis) in Aborted Animals in Jordanian Sheep and Goat Flocks. (21052561)	Samadi A.... Lafi S.Q.	2010
39	Gaps in brucellosis eradication campaign in sheep and goats in Republic of Macedonia: lessons learned. (20718089)	Naletoski I.... Acevski S.	2010
40	Prevalence of brucellosis and infectious bovine rhinotracheitis in organized dairy farms in India. (19644761)	Trangadia B.... Srinivasan V.A.	2010
41	Assessment of diagnostic enzyme-linked immunosorbent assay kit and serological markers in human brucellosis. (18806343)	Cakan G.... Ahmed K.	2008
42	Severe pharyngitis in stockbreeders: an unusual presentation of brucellosis. (18397911)	Zachou K.... Dalekos G.N.	2008
43	Association between the Phe206Leu polymorphism of L-selectin and brucellosis. (16585636)	Rafiei A.... Sheikh N.	2006
44	Meningoencephalitis, pancytopenia, pulmonary insufficiency and splenic abscess in a patient with brucellosis. (16598314)	Cokca F.... Tekeli E.	2006
45	Frequency analysis of the CCR5delta32 mutation in patients with brucellosis. (12587636)	Skendros P.... Theodorou I.	2002
46	Diagnostic usefulness of antibodies against ribosome recycling factor from Brucella melitensis in human or canine brucellosis. (11874879)	Cassataro J.... Baldi P.C.	2002
47	Brucellosis with acute acalculous cholecystitis. (11099103)	Ashley D.... Challapalli M.	2000
48	Occurrence of antibodies to the etiologic agents of infectious bovine rhinotracheitis, parainfluenza 3, leptospirosis, and brucellosis in white-tailed deer in Minnesota. (3005666)	Ingebrigtsen D.K.... McClurkin A.W.	1986
49	Effect of atrophic rhinitis vaccines on the reaction of pigs to serological tests for brucellosis. (4049708)	Corbel M.J.	1985
50	Ovine brucellosis: a review of the disease in sheep manifested by epididymitis and abortion. (14463013)	LAWRENCE W.E.	1961

Genes related to Brucellosis

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Brucellosis:

- Elite gene

id	Symbol	Description	Score	Implication
1	MEFV	Mediterranean fever	21.39	GeneCards inferred via : Disorders (show sections)
2	SAA1	serum amyloid A1	18.53	GeneCards inferred via : Disorders (show sections)
3	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9	15.60	GeneCards inferred via : Publications (show sections)
4	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8	12.75	GeneCards inferred via : Publications (show sections)
5	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	9.89	GeneCards inferred via : Publications, Disorders (show sections)
6	ADA	adenosine deaminase	7.03	GeneCards inferred via : Publications (show sections)
7	CD14	CD14 molecule	4.17	GeneCards inferred via : Publications (show sections)

Products for genes related to Brucellosis disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	7	-	7	7
2	Novus Biologicals	7	7	7	-

Variations for Brucellosis

Expression for genes affiliated with Brucellosis

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Brucellosis

Search GEO for disease gene expression data for Brucellosis.

Pathways for genes affiliated with Brucellosis

Sources:
⁴⁹PathCards, ⁵⁴Reactome, ⁵²QIAGEN
See all sources

Pathways related to Brucellosis according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Toll Like Receptor 7/8 (TLR7/8) Cascade⁵⁴ Show member pathways TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling⁵⁴ Toll Like Receptor 9 (TLR9) Cascade⁵⁴ MyD88 dependent cascade initiated on endosome⁵⁴ TRIF-mediated programmed cell death⁵⁴ TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation⁵⁴ Toll Like Receptor 3 (TLR3) Cascade⁵⁴ MyD88-independent cascade⁵⁴	9.5	CD14, SAA1
2	Presenilin-Mediated Signaling⁵²	9.5	PSMB8, PSMB9
3	SMAD Signaling Network⁵²	9.5	PSMB9, PSMB8
4	Disease⁵⁴	8.5	SLC11A1, PSMB8, PSMB9, SAA1

Compounds for genes affiliated with Brucellosis

Sources:
⁴⁴Novoseek, ⁶⁰Tocris Bioscience, ³BitterDB, ²⁹IUPHAR, ¹²DrugBank, ²⁵HMDB, ⁵⁰PharmGKB
See all sources

Compounds related to Brucellosis according to GeneCards/GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	colchicine⁴⁴ ⁶⁰ ³ ²⁹ ¹²	13.7	MEFV, SAA1
2	endotoxin⁴⁴	9.4	SAA1, MEFV, CD14
3	tuberculin⁴⁴	9.3	ADA, CD14
4	hypoxanthine⁴⁴ ²⁵ ¹²	11.3	ADA, CD14
5	xanthine⁴⁴ ²⁵	10.3	CD14, ADA
6	neopterin⁴⁴	9.2	ADA, CD14
7	alanine⁴⁴	8.7	CD14, SAA1, ADA
8	aspartate⁴⁴	8.6	CD14, SLC11A1, ADA
9	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	11.6	ADA, SAA1, CD14
10	arginine⁴⁴	8.4	SAA1, ADA, CD14

GO Terms for genes affiliated with Brucellosis

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Brucellosis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	spermatoproteasome complex	GO:1990111	9.5	PSMB9, PSMB8
2	proteasome core complex	GO:005839	9.4	PSMB8, PSMB9
3	proteasome complex	GO:000502	9.2	PSMB8, PSMB9
4	extracellular vesicular exosome	GO:070062	8.6	CD14, PSMB9, SAA1, PSMB8

Biological processes related to Brucellosis according to GeneCards/GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cytokine secretion	GO:050715	9.8	SAA1, CD14
2	regulation of cellular amino acid metabolic process	GO:006521	9.8	PSMB9, PSMB8
3	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:051436	9.8	PSMB8, PSMB9
4	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:006977	9.7	PSMB9, PSMB8
5	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:051437	9.7	PSMB9, PSMB8
6	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:051439	9.7	PSMB8, PSMB9
7	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	9.7	PSMB9, PSMB8
8	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	9.6	PSMB8, PSMB9
9	phagocytosis	GO:006909	9.6	SLC11A1, CD14
10	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:031145	9.6	PSMB9, PSMB8
11	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	9.5	PSMB8, PSMB9
12	regulation of apoptotic process	GO:042981	9.5	PSMB8, PSMB9
13	inflammatory response	GO:006954	9.2	CD14, SLC11A1, MEFV
14	protein polyubiquitination	GO:000209	9.2	PSMB9, PSMB8
15	negative regulation of inflammatory response	GO:050728	9.2	ADA, MEFV, SAA1
16	innate immune response	GO:045087	9.1	CD14, SAA1, MEFV
17	apoptotic process	GO:006915	9.0	PSMB9, CD14, PSMB8

Molecular functions related to Brucellosis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	threonine-type endopeptidase activity	GO:004298	9.5	PSMB8, PSMB9

Products for genes affiliated with Brucellosis

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Brucellosis

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: BRC012 MIFTS: 60	Brucellosis malady Rare diseases, Infectious diseases categories
7 symptoms, 7 genes, 14 tissues, 129 related diseases, clinical trials Download this MalaCard Expand all tables

Brucellosis malady