MCID: BRC012
MIFTS: 61

Brucellosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Brucellosis

MalaCards integrated aliases for Brucellosis:

Name: Brucellosis 12 50 56 52 3 42 14 69
Undulant Fever 12 50 3
Gibraltar Fever 12 50
Malta Fever 12 50
Mediterranean Fever 12
Bang's Disease 12
Maltese Fever 12
Cyprus Fever 50
Rock Fever 50

Characteristics:

Orphanet epidemiological data:

56
brucellosis
Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11077
ICD9CM 35 023 023.9
MeSH 42 D002006
NCIt 47 C84602
Orphanet 56 ORPHA1304
MESH via Orphanet 43 D002006
UMLS via Orphanet 70 C0006309
ICD10 via Orphanet 34 A23.0 A23.1 A23.2 more
UMLS 69 C0006309

Summaries for Brucellosis

NIH Rare Diseases : 50 brucellosis is a bacterial infection that spreads from animals to people via unpasteurized dairy products or by exposure to contaminated animal products or infected animals. animals that are most commonly infected include sheep, cattle, goats, pigs, and dogs. brucellosis can cause of range of signs and symptoms, some of which may persist or recur. initial symptoms may include fever, sweats, malaise, anorexia, headache, fatigue, and/or pain in the muscles, joints, and/or back. symptoms that may persist or recur include fevers, arthritis, swelling of the testicle and scrotum, swelling of the heart (endocarditis), neurologic symptoms (in up to 5% of cases), chronic fatigue, depression, and/or swelling of the liver or spleen. people who are in jobs or settings that increase exposure to the bacteria are at increased risk for infection. antibiotics are used to treat brucellosis. recovery may take a few weeks to several months, and relapses are common. death from brucellosis is rare, occurring in no more than 2% of cases. last updated: 12/12/2014

MalaCards based summary : Brucellosis, also known as undulant fever, is related to familial mediterranean fever, ad and toxoplasmosis. An important gene associated with Brucellosis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Abatacept and Mycophenolate mofetil have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Disease Ontology : 12 A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has symptom fever, has symptom sweat, has symptom headache, has symptom back pain, has symptom physical weakness, has symptom joint pain and has symptom fatigue.

Wikipedia : 72 Brucellosis is a highly contagious zoonosis caused by ingestion of unpasteurized milk or undercooked... more...

Related Diseases for Brucellosis

Diseases related to Brucellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 497)
id Related Disease Score Top Affiliating Genes
1 familial mediterranean fever, ad 33.8 CRP MEFV TNF
2 toxoplasmosis 30.5 IL6 TNF
3 chlamydia 30.2 CD40LG IFNG
4 capillary leak syndrome 29.7 CRP CXCL8
5 hemophagocytic lymphohistiocytosis 29.6 IFNG IL10 IL2 IL6 TNF
6 pyelonephritis 29.4 CRP CXCL8 IL10 TNF
7 rift valley fever 29.2 CRP IFNG IL6 SLC11A1 TLR4 TNF
8 tularemia 29.1 CD40LG IFNG IL10 IL2 IL4 TNF
9 myelitis 28.9 IFNG IL10 IL2 IL2RA IL6
10 legionellosis 28.6 CXCL8 IFNG IL2 IL4 IL6 TNF
11 melioidosis 28.3 IFNG IL10 IL18 IL6 TLR4 TNF
12 cryoglobulinemia 28.2 CRP CXCL8 IL10 IL18 IL6
13 lymphoma 27.6 CD40LG IFNG IL10 IL2 IL4 IL6
14 hepatitis b 27.4 CXCL8 IFNG IL10 IL18 IL2RA TNF
15 familial mediterranean fever, ar 12.5
16 brucella melitensis brucellosis 12.2
17 brucella abortus brucellosis 12.2
18 brucella canis brucellosis 12.1
19 brucella suis brucellosis 12.0
20 familial mediterranean fever type 2 12.0
21 familial mediterranean fever type 1 12.0
22 myoclonic astatic epilepsy 10.9 IFNG IL4
23 pure autonomic failure 10.8 IL10 TNF
24 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
25 amyloidosis aa 10.8
26 pyogenic arthritis, pyoderma gangrenosum and acne 10.8
27 amyloidosis, hereditary, transthyretin-related 10.8
28 sternal cleft 10.8 IFNG TNF
29 aortic arch interruption 10.8 IL6 TNF
30 cutaneous leishmaniasis 10.8 IL6 TNF
31 balkan hemorrhagic fever 10.8 CD40LG IL10
32 multiple familial trichoepithelioma 10.8 IL10 TNF
33 peroneal nerve paralysis 10.8 IL10 IL6
34 collagenopathy type 2 alpha 1 10.7 CRP IL6
35 type 1 papillary adenoma of the kidney 10.7 IL10 TNF
36 scirrhous adenocarcinoma 10.7 IL2 TNF
37 herpangina 10.7 IFNG IL10 IL6
38 lung disease 10.7 CD40LG TNF
39 brachydactyly-distal symphalangism syndrome 10.7 CRP IL6
40 indian tick typhus 10.7 CD40LG IFNG
41 thelaziasis 10.7 IFNG IL10 IL4
42 psychologic dyspareunia 10.7 IFNG IL10 TNF
43 acute ackee fruit intoxication 10.7 IL10 IL4 TNF
44 ulcerative colitis 10.6 IL10 IL6 TNF
45 diffuse glomerulonephritis 10.6 IFNG IL4 IL6
46 dumping syndrome 10.6 CD40LG IFNG IL10
47 lagophthalmos 10.6 IL10 IL4 TNF
48 mosaic trisomy 1 10.6 IFNG TNF
49 spondylocostal dysostosis 4 10.6 TLR4 TNF
50 liver leiomyoma 10.6 IL10 IL4 TNF

Graphical network of the top 20 diseases related to Brucellosis:



Diseases related to Brucellosis

Symptoms & Phenotypes for Brucellosis

GenomeRNAi Phenotypes related to Brucellosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 IL18 IL2 IL2RA TNF CD40LG CXCL8
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 IL18 IL2 IL2RA TNF CD40LG CXCL8

MGI Mouse Phenotypes related to Brucellosis:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 CD40LG IFNG IL10 IL18 IL1RN IL2
2 immune system MP:0005387 10.3 IL2 IL2RA IL4 IL6 MEFV SLC11A1
3 cellular MP:0005384 10.29 CD40LG IFNG IL10 IL18 IL1RN IL2
4 homeostasis/metabolism MP:0005376 10.29 CD40LG CRP IFNG IL10 IL18 IL1RN
5 cardiovascular system MP:0005385 10.26 IL10 IL18 IL1RN IL2 IL6 TLR4
6 growth/size/body region MP:0005378 10.25 IFNG IL10 IL18 IL1RN IL2 IL2RA
7 digestive/alimentary MP:0005381 10.24 SLC11A1 TLR4 TNF IFNG IL10 IL18
8 mortality/aging MP:0010768 10.18 IL2 IL2RA IL4 IL6 MEFV SLC11A1
9 endocrine/exocrine gland MP:0005379 10.13 IL2RA IL4 IL6 TNF CD40LG IFNG
10 integument MP:0010771 10.13 CD40LG IFNG IL10 IL18 IL1RN IL4
11 liver/biliary system MP:0005370 10.01 IFNG IL10 IL2 IL4 IL6 MEFV
12 reproductive system MP:0005389 9.96 CD40LG IFNG IL10 IL1RN IL2 IL4
13 neoplasm MP:0002006 9.87 IL2 IL6 SLC11A1 TLR4 TNF IFNG
14 respiratory system MP:0005388 9.76 IL2 IL2RA IL4 IL6 TLR4 TNF
15 skeleton MP:0005390 9.61 CD40LG IFNG IL10 IL1RN IL4 IL6
16 vision/eye MP:0005391 9.28 IFNG IL10 IL18 IL2 IL2RA IL4

Drugs & Therapeutics for Brucellosis

Drugs for Brucellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 759)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 4 332348-12-6 10237
2
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
3
Mycophenolic acid Approved Phase 4 24280-93-1 446541
4
Tacrolimus Approved, Investigational Phase 4,Phase 3 104987-11-3 445643 439492
5
Atenolol Approved Phase 4 29122-68-7 2249
6
Nicorandil Approved Phase 4 65141-46-0 47528
7
Methyltestosterone Approved Phase 4,Phase 3 58-18-4 6010
8
Testosterone Approved, Investigational Phase 4,Phase 3 58-22-0 6013
9
Heroin Approved, Illicit Phase 4 561-27-3 5462328
10
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
11
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
12
Colchicine Approved Phase 4,Phase 3,Phase 2,Phase 1 64-86-8 6167 2833
13
Adenosine Approved, Investigational Phase 4,Phase 2 58-61-7 60961
14
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
15
Maraviroc Approved, Investigational Phase 4,Phase 2,Phase 3 376348-65-1 3002977
16
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
17
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
18
Telavancin Approved Phase 4 372151-71-8
19
Oseltamivir Approved Phase 4,Phase 3 204255-11-8, 196618-13-0 65028
20
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
21
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991
22
Regadenoson Approved Phase 4 313348-27-5 219024
23
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
24
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
25
Vancomycin Approved Phase 4 1404-90-6 441141 14969
26
Nicotine Approved Phase 4 54-11-5 942 89594
27
Citalopram Approved Phase 4,Phase 3,Phase 2 59729-33-8 2771
28
Donepezil Approved Phase 4,Phase 2 120014-06-4 3152
29
Norepinephrine Approved Phase 4,Phase 2 51-41-2 439260
30
Zinc Approved Phase 4,Phase 2 7440-66-6 32051 23994
31
Memantine Approved, Investigational Phase 4,Phase 2 19982-08-2 4054
32
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
33
Amodiaquine Approved Phase 4,Phase 3 86-42-0 2165
34
Artesunate Approved Phase 4,Phase 3 88495-63-0 6917864 5464098
35
Selegiline Approved, Investigational, Vet_approved Phase 4 14611-51-9 26757 5195
36
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
37
Dapsone Approved, Investigational Phase 4 80-08-0 2955
38
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
39
Ibuprofen Approved Phase 4 15687-27-1 3672
40
Naproxen Approved, Vet_approved Phase 4,Phase 2 22204-53-1 1302 156391
41
Ramipril Approved Phase 4 87333-19-5 5362129
42
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
43
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 1 616-91-1 12035
44
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
45
Sertraline Approved Phase 4 79617-96-2 68617
46
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
47
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 1 437-38-7 3345
48
Ketamine Approved, Vet_approved Phase 4,Phase 1,Phase 2 6740-88-1 3821
49
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2 57-27-2 5288826
50
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 2 76-42-6 5284603

Interventional clinical trials:

(show top 50) (show all 883)

id Name Status NCT ID Phase Drugs
1 VeinViewer Assisted Intravenous Catheter Placement in the Pediatric Emergency Department Unknown status NCT00468065 Phase 4
2 Comparison of NODAT in Kidney Transplant Patients Receiving Belatacept Versus Standard Immunosuppression Unknown status NCT01875224 Phase 4 Belatacept;Tacrolimus
3 Study to Assess Efficacy of Nicorandil+Atenolol vs Atenolol in Treatment of Chronic Stable Angina. Unknown status NCT01397994 Phase 4 Nicorandil;Atenolol
4 Injection Assistance Device Versus Manual Injections for Delivery of Dermal Fillers Unknown status NCT01492140 Phase 4
5 Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal Men Unknown status NCT01699178 Phase 4 Oral testosterone undecanoate;Transdermal testosterone gel (AndroGel)
6 Nasal Naloxone for Narcotic Overdose Unknown status NCT01912573 Phase 4 Intranasal (IN) naloxone;Intravenous (IV) naloxone;Intramuscular (IM) naloxone;Intraosseus (IO) naloxone
7 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
8 Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD) Unknown status NCT01272531 Phase 4 Mood stabilizer treatment
9 The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With FMF Completed NCT02602028 Phase 4 colchicine
10 A Study of the Neurological Effects of Adding Maraviroc to HAART Regimen in Patients With HIV (HANDmac) Completed NCT01449006 Phase 4 Maraviroc
11 Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD) Completed NCT00663403 Phase 4 Daptomycin
12 Cardiac Limitations in Chronic Obstructive Pulmonary Disease: Benefits of Bronchodilation Completed NCT00578968 Phase 4 Tiotropium;Placebo
13 Pharmacokinetics of Single-Dose Oral Ranolazine in Hemodialysis Patients Completed NCT01435174 Phase 4 Ranolazine
14 Effect of Dialysis on the Pharmacokinetics of Telavancin in Patients With Chronic Kidney Disease Stage 5 Completed NCT02392208 Phase 4 Telavancin
15 Pharmacokinetics of Tamiflu® (Oseltamivir) in Patients Receiving Extracorporeal Membrane Oxygenation (ECMO)and or Continuous Venovenous Hemodialysis (CVVHD) Completed NCT01048879 Phase 4
16 Pharmacokinetics of Ertapenem in Continuous Venovenous Hemodialysis Completed NCT00877370 Phase 4 ertapenem
17 The Effects of the Rivastigmine Patch on Parkinson's Disease With Memory and/or Thinking Problems Completed NCT00988117 Phase 4 Rivastigmine Patch 9.5 cm2
18 Integrated Dual Exercise and Lexiscan Positron Emission Tomography: IDEALPET Completed NCT01109992 Phase 4 Exercise plus Regadenoson (Lexercise);Regadenoson (Lexiscan)
19 Rural Andhra Pradesh Cardiovascular Prevention Study (RAPCAPS) Completed NCT00263393 Phase 4 ASA, Atenolol, hydrochlorothiazide, ACE inhibitor, Statin
20 ULTRA Study for Pacemaker Patients Completed NCT00133289 Phase 4
21 Effect of Age on Latanoprost 0.005% in Patients With Glaucoma Completed NCT00224289 Phase 4 Latanoprost 0.005%
22 Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas Completed NCT00295178 Phase 4 Daptomycin;Vancomycin
23 Helping Those With Mental Illness Quit Smoking Completed NCT01783912 Phase 4 Nicotine Patch
24 Ankle Block Versus Popliteal Fossa Block as Primary Anesthesia for Forefoot Surgical Procedures Completed NCT01376960 Phase 4
25 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
26 Antidepressant Medication Plus Donepezil for Treating Late-life Depression Completed NCT00177671 Phase 4 Escitalopram;Donepezil;Venlafaxine;Placebo;Duloxetine
27 Needle Length In Obese Insulin-Using Diabetic Subjects Completed NCT00541372 Phase 4
28 Foot and Ankle Clinic Application for Liposomal Related Anesthetic Completed NCT02586077 Phase 4 Exparel
29 Comparative Performance of PureVision, Acuvue Oasys and O2Optix Completed NCT00640341 Phase 4
30 Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia Completed NCT00545974 Phase 4 memantine;Placebo pill
31 Safety and Acceptability of the PrePex™ Device for Male Circumcision in Zambia Completed NCT01844102 Phase 4
32 Study of Long-term Peg Intron vs. Colchicine in Non-responders. Completed NCT00179413 Phase 4 PEG -Intron;Colchicine
33 Restricting the Use of Artesunate Plus Amodiaquine Combination Therapy to Malaria Cases Confirmed by a Dipstick Test: A Cluster Randomised Control Trial Completed NCT00832754 Phase 4
34 Phase IV:Safety and Efficacy of EMSAM in Adolescents With Major Depression Completed NCT00531947 Phase 4 Selegiline Transdermal System;Placebo
35 Evaluation of Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea® vs Placebo Completed NCT01308619 Phase 4 Doxycycline
36 Phase IV Study to Gather More Information About the Safety of ACZONE Gel, 5% in Treating Subjects With Acne Who Have G6PD Deficiency Completed NCT00243542 Phase 4 ACZONE Gel, 5%;Vehicle
37 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Completed NCT00346216 Phase 4 celecoxib;Ibuprofen;Naproxen
38 Effectiveness and Safety of Ramipril Alone Compared With Telmisartan Alone and in Combination With Ramipril in Patients at High Risk for Cardiovascular Events. Patients Intolerant to Ramipril Were Entered in TRANSCEND, Telmisartan Compared to Placebo. Completed NCT00153101 Phase 4 Telmisartan;Combination of Telmisartan and Ramipril;Ramipril
39 Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease Recruiting NCT02476526 Phase 4 Low Volume iso-osmolar non-ionic radio contrast medium;Acetylcysteine Inhalation;Sodium Bicarbonate Solution
40 Corticosteroids With Vedolizumab in Crohn's Disease Recruiting NCT02324699 Phase 4 Prednisone;Placebo;Vedolizumab
41 International Study to Predict Optimised Treatment - in Depression Recruiting NCT00693849 Phase 4 Escitalopram;Sertraline;Venlafaxine-XR
42 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT00867815 Phase 4 Diagnostic procedures
43 A Study of Two Different Doses of Cabozantinib (XL184) in Progressive, Metastatic Medullary Thyroid Cancer Recruiting NCT01896479 Phase 4 Cabozantinib (XL184) 140 mg;Cabozantinib (XL184) 60 mg;Placebo tablet;Placebo capsule
44 AAA Registry: Clinical Outcomes of Highly Angulated anatomY Treated With the Aorfix™ Stent Graft Recruiting NCT02480595 Phase 4
45 Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study Recruiting NCT02202369 Phase 4
46 A Prospective Study of the InterFuse T(tm), Recruiting NCT02678130 Phase 4
47 Sleep and Cognition After Atripla to Stribild Switch Recruiting NCT02283060 Phase 4 Stribild;Atripla
48 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
49 Reducing the Acute Care Burden of Childhood Asthma on Health Services in British Columbia Active, not recruiting NCT01326494 Phase 4 Arm 1 Oral Cortico Steroids
50 World-wide Randomized Antibiotic Envelope Infection Prevention Trial Active, not recruiting NCT02277990 Phase 4

Search NIH Clinical Center for Brucellosis

Cochrane evidence based reviews: brucellosis

Genetic Tests for Brucellosis

Anatomical Context for Brucellosis

MalaCards organs/tissues related to Brucellosis:

39
Breast, Testes, Heart, Brain, Prostate, Lung, Liver

Publications for Brucellosis

Articles related to Brucellosis:

(show top 50) (show all 746)
id Title Authors Year
1
Caprine brucellosis: A historically neglected disease with significant impact on public health. ( 28817647 )
2017
2
Sixteen Chinese pediatric brucellosis patients onset of fever in non-epidemic areas and 8 developed with osteoarticular involvement. ( 28924723 )
2017
3
Epidemiology of bovine brucellosis in Costa Rica: Lessons learned from failures in the control of the disease. ( 28797045 )
2017
4
Guidelines for the management of human brucellosis in the State of ParanA!, Brazil. ( 28954065 )
2017
5
Intestinal brucellosis associated with celiac artery and superior mesenteric artery stenosis and with ileum mucosa and submucosa thickening: A case report. ( 28079834 )
2017
6
The economic efficiency and equity of government policies on brucellosis: comparative insights from Albania and the United States of America. ( 28926008 )
2017
7
Brucellosis in a Clymene dolphin (Stenella clymene) stranded in Brazil. ( 28816014 )
2017
8
Effect of hydroxychloroquine on treatment and recurrence of acute brucellosis: a single-blind randomized clinical trial. ( 28826825 )
2017
9
Protective efficacy by various doses of a new brucellosis vaccine candidate based on Salmonella strains expressing Brucella abortus BSCP31, Omp3b and superoxide dismutase against brucellosis in murine model. ( 28873944 )
2017
10
Evolution of bovine brucellosis in Colombia over a 7-year period (2006-2012). ( 28905264 )
2017
11
Safety of vaccination against brucellosis with the rough strain in pregnant cattle. ( 28812192 )
2017
12
Reprint of "Epidemiology of brucellosis, Q Fever and Rift Valley Fever at the human and livestock interface in northern CA'te d'Ivoire". ( 28867393 )
2017
13
Seroepidemiology of Human Brucellosis Among Blood Donors in Southern Ethiopia: Calling Attention to a Neglected Zoonotic Disease. ( 28077743 )
2017
14
A serosurvey for ruminant pestivirus exposure conducted using cattle sera collected for brucellosis surveillance in the United States. ( 28074709 )
2017
15
Brucellosis in livestock and wildlife: zoonotic diseases without pandemic potential in need of innovative one health approaches. ( 28904791 )
2017
16
Fludarabine is effective in treating refractory hemophagocytic lymphohistiocytosis with brucellosis. ( 28378406 )
2017
17
Evaluation of the cost-effectiveness of bovine brucellosis surveillance in a disease-free country using stochastic scenario tree modelling. ( 28859107 )
2017
18
Brucellosis: A lymphoma-like presentation. ( 28942834 )
2017
19
The IL4-VNTR P1 Allele, IL4-VNTR P2P2 Genotype, and IL4-VNTR_IL6-174CG P2P1-GG Genotype Are Associated with an Increased Risk of Brucellosis. ( 27169944 )
2017
20
Brucellosis as a neglected disease in a neglected population: a seroepidemiological study of migratory nomads in the Fars province of Iran. ( 27866494 )
2017
21
Seroprevalence of Brucellosis in Human Immunodeficiency Virus Infected Patients in Hamadan, Iran. ( 28904852 )
2017
22
Reduced IFN-I^ Production in Chronic Brucellosis Patients. ( 28919584 )
2017
23
Methodology for the assessment of brucellosis management practices and its vaccination campaign: example in two Argentine districts. ( 28882137 )
2017
24
Development of improved enzyme-based and lateral flow immunoassays for rapid and accurate serodiagnosis of canine brucellosis. ( 28888634 )
2017
25
Brucellosis and thrombosis of the inferior vena cava. ( 27871206 )
2017
26
Does Helicobacter pylori infection play a role in susceptibility to Brucellosis? ( 28890508 )
2017
27
Isolated splenic abscess in brucellosis. ( 28473914 )
2017
28
Seroprevalence of Leptospirosis, Brucellosis, and Q Fever in a Wild Red Deer (Cervus elaphus) Population Kept in a Fenced Reserve in Absence of Contact with Livestock. ( 28873022 )
2017
29
Are brucellosis, Q fever and melioidosis potential causes of febrile illness in Madagascar? ( 28502643 )
2017
30
Is Human Brucellosis Endemics in Korea? ( 27873523 )
2017
31
[THE PERSPECTIVES OF STUDYING OF POLYMORPHISM OF GENES OF GAMMA-INTERFERON UNDER CHRONIC BRUCELLOSIS]. ( 27455566 )
2016
32
Progressive encephalomyelitis with rigidity and myoclonus (PERM): brucellosis as a possible triggering factor and long-term follow-up therapy with rituximab. ( 26788132 )
2016
33
Modelling Seasonal Brucellosis Epidemics in Bayingolin Mongol Autonomous Prefecture of Xinjiang, China, 2010-2014. ( 27872852 )
2016
34
Brucellosis in pregnant women from Pakistan: an observational study. ( 27590009 )
2016
35
Brucellosis Outbreak in Children and Adults in Two Areas in Israel. ( 27114301 )
2016
36
Epidemiological study of bovine brucellosis in three senatorial zones of Bauchi State, Nigeria. ( 27051184 )
2016
37
Epidemiology of brucellosis, Q Fever and Rift Valley Fever at the human and livestock interface in northern CA'te d'Ivoire. ( 26899680 )
2016
38
Brucellosis With Multi-Organ Involvement in a Patient With History of Composite Aortic Graft and Hepatitis B. ( 28033700 )
2016
39
Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. ( 27658298 )
2016
40
Contagious Ecthyma, Rangiferine Brucellosis, and Lungworm Infection in a Muskox ( Ovibos moschatus ) from the Canadian Arctic, 2014. ( 27285415 )
2016
41
Bovine and Caprine Brucellosis in Bangladesh: Bayesian evaluation of four serological tests, true prevalence, and associated risk factors in household animals. ( 27628065 )
2016
42
Epidemic characteristics, high-risk townships and space-time clusters of human brucellosis in Shanxi Province of China, 2005-2014. ( 27993134 )
2016
43
Utility of Serological Tests in the Era of Molecular Testing for Diagnosis of Human Brucellosis in Endemic Area with Limited Resources. ( 27042465 )
2016
44
Imported brucellosis: A case series and literature review. ( 27185403 )
2016
45
Outbreak of Occupational Brucellosis at a Pharmaceutical Factory in Southeast China. ( 27863096 )
2016
46
Polymerase Chain Reaction-Based Assays for the Diagnosis of Active and Relapsed Cases of Human Brucellosis. ( 27928078 )
2016
47
Renal manifestations of human brucellosis: First report of minimal change disease. ( 27215256 )
2016
48
A randomized, comparative study of dual therapy (doxycycline-rifampin) versus triple therapy (doxycycline-rifampin-levofloxacin) for treating acute/subacute brucellosis. ( 27086734 )
2016
49
Seroprevalence of Q Fever, Brucellosis, and Bluetongue in Selected Provinces in Lao People's Democratic Republic. ( 27430548 )
2016
50
Analysis of IL-10 and IL-6 Gene Polymorphisms and Their Serum Levels in Patients with Brucellosis: A Case Control Study. ( 26849072 )
2016

Variations for Brucellosis

Expression for Brucellosis

Search GEO for disease gene expression data for Brucellosis.

Pathways for Brucellosis

Pathways related to Brucellosis according to GeneCards Suite gene sharing:

(show top 50) (show all 80)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CD40LG CRP CXCL8 IFNG IL10 IL18
2
Show member pathways
13.87 CD40LG CXCL8 IL10 IL18 IL2 IL2RA
3
Show member pathways
13.76 CD40LG CXCL8 IFNG IL10 IL18 IL2
4
Show member pathways
13.61 CXCL8 IFNG IL10 IL18 IL2 IL2RA
5
Show member pathways
13.52 CD40LG CXCL8 IL10 IL18 IL2 IL2RA
6
Show member pathways
13.44 CD40LG CXCL8 IFNG IL10 IL18 IL1RN
7
Show member pathways
13.41 CD40LG CXCL8 IL10 IL18 IL2 IL2RA
8
Show member pathways
13.22 IFNG IL2 IL2RA IL4 TLR4 TNF
9
Show member pathways
13.1 CXCL8 IL18 IL1RN IL6 MEFV TLR4
10
Show member pathways
13.01 CXCL8 IFNG IL10 IL2 IL6 TLR4
11
Show member pathways
12.95 CD40LG CXCL8 IFNG IL10 IL2 IL2RA
12
Show member pathways
12.89 CXCL8 IFNG IL18 IL2 IL2RA IL4
13
Show member pathways
12.83 IL2 IL2RA IL4 IL6 TNF
14
Show member pathways
12.78 CXCL8 IFNG IL18 IL6 TNF
15
Show member pathways
12.78 CD40LG IFNG IL10 IL18 IL2 IL2RA
16
Show member pathways
12.75 CD40LG IL2 IL6 TLR4 TNF
17 12.74 IL2 IL2RA IL4 IL6 TLR4 TNF
18
Show member pathways
12.72 IFNG IL10 IL18 IL2 IL6 TNF
19 12.66 CD40LG IFNG IL10 IL1RN IL2 IL2RA
20
Show member pathways
12.65 IFNG IL10 IL18 IL2 IL2RA IL4
21
Show member pathways
12.59 CD40LG IFNG IL10 IL2 IL4 IL6
22
Show member pathways
12.53 IFNG IL2 IL4 TNF
23 12.46 IL2 IL2RA IL6 TNF
24
Show member pathways
12.45 CXCL8 IFNG IL4 IL6 TNF
25
Show member pathways
12.42 CD40LG IFNG IL10 IL4 TLR4 TNF
26
Show member pathways
12.4 CXCL8 IFNG IL6 TLR4 TNF
27 12.39 IFNG IL10 IL18 IL6 TLR4 TNF
28
Show member pathways
12.37 IFNG IL10 IL2 IL2RA IL4 IL6
29
Show member pathways
12.34 CXCL8 IFNG IL4 IL6 TLR4 TNF
30 12.32 CXCL8 IL10 IL1RN IL6 TNF
31 12.25 IFNG IL6 TLR4 TNF
32 12.16 CXCL8 IL10 IL18 IL4 IL6 TNF
33
Show member pathways
12.15 IFNG IL18 IL2 IL2RA IL4
34 12.13 CXCL8 IFNG IL2 IL4 IL6 TLR4
35 12.11 IFNG IL10 IL2 IL2RA IL4 IL6
36 12.07 CXCL8 IFNG IL10 IL6 TLR4 TNF
37
Show member pathways
12.05 IFNG IL10 IL18 IL2 IL6 TLR4
38 12.04 IFNG IL10 IL2 IL2RA IL6
39
Show member pathways
12.03 IFNG IL4 IL6 TLR4
40 12.02 IL2RA IL4 IL6 TNF
41 12.02 CXCL8 IFNG IL18 IL6 TLR4 TNF
42 12.01 CD40LG CXCL8 TLR4 TNF
43 12.01 CXCL8 IFNG IL18 IL6 TLR4
44 11.99 CXCL8 IL18 IL2 TLR4
45 11.99 CXCL8 IFNG IL2 IL4 IL6
46
Show member pathways
11.97 CXCL8 IFNG IL10 IL18 IL2 IL4
47 11.96 CXCL8 IFNG IL6
48 11.94 CXCL8 IL10 IL6 TLR4 TNF
49 11.94 IFNG IL10 IL2 IL6 TNF
50 11.92 CXCL8 IL6 TNF

GO Terms for Brucellosis

Cellular components related to Brucellosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 CD40LG CRP CXCL8 IFNG IL10 IL18
2 intracellular GO:0005622 9.8 CD40LG CXCL8 IL1RN IL2 IL2RA MEFV
3 extracellular space GO:0005615 9.7 CD40LG CRP CXCL8 IFNG IL10 IL18
4 external side of plasma membrane GO:0009897 9.17 CD40LG IFNG IL2RA IL4 IL6 TLR4

Biological processes related to Brucellosis according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.99 IL10 IL6 SLC11A1 TLR4
2 defense response to bacterium GO:0042742 9.99 IFNG IL10 SLC11A1 TLR4 TNF
3 positive regulation of protein phosphorylation GO:0001934 9.97 IFNG IL2 IL4 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 CD40LG IL6 TLR4 TNF
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.93 IL10 IL4 IL6 TNF
6 positive regulation of gene expression GO:0010628 9.93 CRP IFNG IL6 SLC11A1 TLR4 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.92 CRP IL6 TNF
8 positive regulation of protein kinase B signaling GO:0051897 9.92 IL18 IL6 TNF
9 negative regulation of inflammatory response GO:0050728 9.91 IL10 IL2 IL2RA MEFV
10 defense response to Gram-negative bacterium GO:0050829 9.9 IL6 SLC11A1 TLR4
11 B cell differentiation GO:0030183 9.89 CD40LG IL10 IL4
12 positive regulation of inflammatory response GO:0050729 9.89 IL18 IL2 TLR4
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.89 IL18 IL6 TNF
14 cellular response to lipopolysaccharide GO:0071222 9.88 CXCL8 IFNG IL10 IL6 TLR4 TNF
15 humoral immune response GO:0006959 9.87 IFNG IL6 TNF
16 response to glucocorticoid GO:0051384 9.87 IL10 IL1RN IL6 TNF
17 positive regulation of interleukin-6 production GO:0032755 9.86 IL6 TLR4 TNF
18 positive regulation of B cell proliferation GO:0030890 9.85 IL2 IL4 TLR4
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IFNG IL6 TLR4 TNF
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 IFNG IL18 IL2 IL4 IL6
21 response to bacterium GO:0009617 9.82 IL6 SLC11A1 TLR4
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.82 IL18 TLR4 TNF
23 negative regulation of interleukin-6 production GO:0032715 9.81 IL10 TLR4 TNF
24 positive regulation of interleukin-12 production GO:0032735 9.8 CD40LG IFNG TLR4
25 positive regulation of activated T cell proliferation GO:0042104 9.8 IL18 IL2 IL2RA IL4
26 positive regulation of interleukin-10 production GO:0032733 9.79 CD40LG IL4 TLR4
27 positive regulation of NF-kappaB import into nucleus GO:0042346 9.79 IL18 TLR4 TNF
28 positive regulation of T cell differentiation GO:0045582 9.77 IL2 IL2RA IL4
29 positive regulation of interferon-gamma production GO:0032729 9.77 IL18 IL2 SLC11A1 TLR4 TNF
30 immune response GO:0006955 9.77 CD40LG CXCL8 IFNG IL10 IL18 IL1RN
31 positive regulation of chemokine production GO:0032722 9.76 IL6 TLR4 TNF
32 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.75 IFNG TNF
33 cellular response to hepatocyte growth factor stimulus GO:0035729 9.75 IL10 IL6
34 positive regulation of interleukin-17 production GO:0032740 9.75 IL18 IL2
35 response to molecule of bacterial origin GO:0002237 9.75 CXCL8 IL10
36 negative regulation of growth of symbiont in host GO:0044130 9.75 IFNG IL10 TNF
37 negative regulation of interleukin-12 production GO:0032695 9.74 IL10 MEFV
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.74 IL10 TNF
39 positive regulation of immunoglobulin secretion GO:0051024 9.74 IL2 IL6
40 positive regulation of protein import into nucleus, translocation GO:0033160 9.73 IFNG IL6
41 T-helper 1 type immune response GO:0042088 9.73 IL18 TLR4
42 negative regulation of interleukin-17 production GO:0032700 9.73 IFNG TLR4
43 macrophage activation GO:0042116 9.73 SLC11A1 TLR4
44 positive regulation of isotype switching to IgG isotypes GO:0048304 9.73 IFNG IL2 IL4
45 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.72 IL10 IL1RN
46 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.72 TLR4 TNF
47 endothelial cell apoptotic process GO:0072577 9.72 IL10 TNF
48 positive regulation of T-helper 2 cell differentiation GO:0045630 9.72 IL18 IL6
49 positive regulation of chemokine biosynthetic process GO:0045080 9.72 IFNG IL4 TNF
50 negative regulation of lymphocyte proliferation GO:0050672 9.71 IL2 IL2RA

Molecular functions related to Brucellosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 CD40LG CXCL8 IFNG IL10 IL18 IL1RN
2 growth factor activity GO:0008083 9.26 IL10 IL2 IL4 IL6

Sources for Brucellosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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