Brugada Syndrome malady

NIH Rare Diseases: Brugada syndrome causes a disruption of the heart's normal rhythm. Signs and symptoms usually develop in adulthood and include ventricular arrhythmia that can cause fainting, seizures, difficulty breathing, or sudden death. These complications typically occur when an affected person is resting or asleep. The underlying cause of Brugada syndrome can not always be identified. In some cases it is due to mutations in the SCN5A gene. Other cases are not genetic (are not due to a gene mutation), but acquired due to adverse reactions to drugs or associated with very low or high levels of potassium, or high levels of calcium.³⁰

MalaCards: Brugada Syndrome, also known as sudden unexpected nocturnal death syndrome, is related to brugada syndrome 2 and conduction disease. An important gene associated with Brugada Syndrome is SCN1B (sodium channel, voltage-gated, type I, beta subunit), and among its related pathways are Cholera Infection and Axon guidance. The compounds flecainide and propafenone have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and b cells, and related mouse phenotype cardiovascular system.

Disease Ontology: A heart conduction disease that is characterised by abnormal electrocardiogram (ecg) findings and an increased risk of sudden cardiac death.⁶

Genetics Home Reference: Brugada syndrome is a condition that causes a disruption of the heart's normal rhythm. Specifically, this disorder can lead to uncoordinated electrical activity in the heart's lower chambers (ventricles), an abnormality called ventricular arrhythmia. If untreated, the irregular heartbeats can cause fainting (syncope), seizures, difficulty breathing, or sudden death. These complications typically occur when an affected person is resting or asleep.¹⁷

Wikipedia: The Brugada syndrome is a genetic disease that is characterised by abnormal electrocardiogram (ECG)...⁴⁴ more...

GeneReviews summary for brugada

Aliases & Descriptions:

brugada syndrome 6 7 15 30 16 17 8 32 sudden unexpected nocturnal death syndrome 15 30 16 17 43 right bundle branch block, st segment elevation, and sudden death syndrome 30 sudden unexplained death syndrome 17

brugada syndrome (disorder) 43 sudden cardiac death 43 suds 17

Disease types for brugada syndrome family:

brugada syndrome 3	brugada syndrome 4
brugada syndrome 1	brugada syndrome 2
brugada syndrome 5	brugada syndrome 6
brugada syndrome 7	brugada syndrome 8

Diseases related to brugada syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 72)

id	Related Disease	Score	Top Affiliating Genes
1	brugada syndrome 2	32.3	GPD1L, SCN5A
2	conduction disease	31.6	CACNB2, SCN3B, SCN5A, SCN1B
3	myocardial infarction	30.9	KCNE1, KCNQ1, KCND3, KCNE2, KCNJ8, SCN5A
4	catecholaminergic polymorphic ventricular tachycardia	29.9	KCNH2, KCNE2, SCN5A
5	sick sinus syndrome	28.5	SCN5A, HCN4
6	congenital heart defect	28.5	SCN5A, KCNE2, KCNQ1, KCNH2, KCNE1
7	sudden cardiac death multi-gene panels	28.4	SCN5A, KCNE2, KCNQ1, KCNH2, KCNE1
8	long qt syndrome	27.7	GPD1L, HCN4, CACNA1C, SCN5A, SCN1B, KCNE2
9	sinusitis	27.5	HCN4, SCN5A, KCNQ1, KCNH2
10	ventricular fibrillation	27.3	SCN1B, SCN5A, SCN3B, GPD1L, CACNB2, HCN4
11	syncope	26.7	HCN4, SCN5A, KCNE2, KCNQ1, KCNH2, KCNE1
12	sudden infant death syndrome	25.9	KCNE1, KCNH2, KCNQ1, KCND3, KCNE2, KCNJ8
13	atrial fibrillation	25.5	KCNE2, SCN1B, SCN5A, SCN3B, HCN4, CACNA1C
14	long qt syndrome 2	13.4	SCN5A, KCNH2
15	congenital heart block	13.3	SCN5A, KCNH2
16	hyperkalemic periodic paralysis	13.3	KCNE3, SCN1B
17	migraine without aura	13.2	CACNB2, ANK3
18	sinus bradycardia syndrome	13.1	KCNQ1, KCNH2
19	short qt syndrome	13.0	KCNQ1, KCNH2
20	fibrillary astrocytoma	13.0	SCN5A, KCNQ1
21	hypokalemic periodic paralysis	13.0	KCNE3, CACNA1C
22	alpha 1-antitrypsin deficiency	12.9	SCN5A, KCNH2
23	timothy syndrome	12.9	CACNA1C, PSMC4
24	jervell-lange nielsen syndrome	12.9	KCNQ1, KCNE1
25	familial atrial fibrillation	12.7	KCNQ1, KCNE2, SCN5A
26	supravalvular aortic stenosis	12.7	SCN5A, KCNH2
27	congenital deafness with labyrinthine aplasia, microtia, and microdontia	12.7	KCNE1, KCNQ1
28	conduct disorder	12.7	SCN5A, KCNQ1, KCNH2
29	hypokalemia	12.4	KCNQ1, KCNH2, KCNE3, KCNE1
30	heart block	12.3	KCNE1, KCNQ1, KCNE2, SCN5A
31	gastroparesis	12.2	KCNE1, KCNH2, KCNQ1, KCNE2
32	epilepsy syndrome	12.2	KCNH2, KCNQ1, SCN1B, PSMC4
33	episodic ataxia	12.1	KCNH2, KCND3, PSMC4
34	right bundle branch block	12.1	SCN3B, GPD1L, CACNB2, HCN4, CACNA1C, SCN5A
35	long qt syndrome 1	12.1	SCN5A, KCNE2, KCNQ1, KCNH2, KCNE1
36	noonan syndrome	12.0	CACNA1C, HCN4, PKP2, CACNB2, SCN5A, KCNH2
37	aldosteronism	12.0	HCN4, GPD1, KCNQ1, KCNE1
38	fainting	11.9	KCNE3, KCNH2, SCN1B, SCN5A, SCN3B, GPD1L
39	cardiomyopathy	10.0
40	arrhythmogenic right ventricular dysplasia/cardiomyopathy multi-gene panels	9.5	KCNE1, KCNE3, KCNH2, KCNQ1, KCND3, KCNE2
41	neuronitis	9.4	CACNA1C, PSMC4, HCN4, CACNB2, ANK3, SCN3B
42	hypertrophic cardiomyopathy	9.1
43	acute myocardial infarction	8.8
44	brugada syndrome 3	8.1
45	brugada syndrome 4	8.1
46	dilated cardiomyopathy	7.9
47	brugada syndrome 1	7.8
48	brugada syndrome 5	7.8
49	brugada syndrome 6	7.8
50	brugada syndrome 7	7.8

Approved drugs:

Drug clinical trials:

Genetic tests related to brugada syndrome:

id	Genetic test	Affiliating Genes
1	Brugada Syndrome clinical/research	KCNE3, SCN1B, SCN5A, SCN3B, GPD1L, CACNB2, HCN4, CACNA1C

MalaCards organs/tissues related to brugada syndrome:

²²

MGI Mouse Phenotypes related to brugada syndrome:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system phenotype	MP:0005385	INF	KCNE1, HCN4, PKP2, CACNB2, SCN3B, SCN5A

Articles related to brugada syndrome:

(show top 50)    (show all 125)

id	Title	Authors	Year	Affiliating Genes
1	MOG1: a new susceptibility gene for Brugada syndrome. (21447824)	Kattygnarath D.... Guicheney P.	2011	RANGRF
2	Identification of six novel SCN5A mutations in Japane se patients with Brugada syndrome. (21321465)	Nakajima T.... Kurabayashi M.	2011	SCN5A
3	Prospective evaluation of the familial prevalence of the brugada syndrome. (21126620)	Hermida J.S.... Jarry G.	2010	SCN5A
4	An international compendium of mutations in the SCN5A -encoded cardiac sodium channel in patients referred for Brugada syndrome genet ic testing. (20129283)	Kapplinger J.D.... Ackerman M.J.	2010	SCN5A
5	SCN5A mutations and the role of genetic background in the pathophysiology of Brugada syndrome. (20031634)	Probst V.... Schott J.J.	2009	SCN5A
6	Genetic modulation of brugada syndrome by a common po lymorphism. (19549036)	Lizotte E.... Brugada R.	2009	SCN5A
7	A novel SCN5A mutation V1340I in Brugada syndrome aug menting arrhythmias during febrile illness. (19648062)	Samani K.... Vatta M.	2009	SCN5A
8	The genetic basis of Brugada syndrome: a mutation upd ate. (19606473)	Hedley P.L.... Christiansen M.	2009	GPD1L
9	Ventricular tachycardia in a Brugada syndrome patient caused by a novel deletion in SCN5A. (19279983)	Tfelt-Hansen J.... Haunso S.	2009	SCN5A
10	Dynamic change in ST-segment and spontaneous occurrence of ventricular fibrillation in Brugada syndrome with a novel nonsense mutation in the SCN5A gene during long-term follow-up. (19075524)	Kawamura M.... Horie M.	2009	SCN5A
11	Atrial fibrillation in patients with Brugada syndrome relationships of gene mutation, electrophysiology, and clinical backgrounds. (18355654)	Kusano K.F.... Ohe T.	2008	SCN5A
12	Analyses of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome. (18252757)	Petitprez S.... Kucera J.P.	2008	SCN5A
13	Characterization of a novel SCN5A mutation associated with Brugada syndrome reveals involvement of DIIIS4-S5 linker in slow inactivation. (17854786)	Casini S.... Veldkamp M.W.	2007	SCN5A
14	A sodium channel pore mutation causing Brugada syndrome. (17198989)	Pfahnl A.E.... Dudley S.C. Jr.	2007	SCN5A
15	Brugada syndrome unmasked by accidental inhalation of gasoline vapors. (17897138)	Kranjcec D.... Abriel H.	2007	SCN5A
16	Brugada syndrome and work place: two case report (17886758)	Martini A.... Fantini S.	2007	SCN5A
17	A novel mutation in the SCN5A gene is associated with Brugada syndrome. (17141278)	Shin D.J.... Yoon S.K.	2007	SCN5A
18	Long QT and Brugada syndrome gene mutations in New Zealand. (17905336)	Chung S.K.... Rees M.I.	2007	KCNQ1, KCNH2, KCNE1
19	Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease. (16877553)	Zhang Z.S.... Grant A.O.	2007	SCN5A
20	Monomorphic ventricular tachycardia due to Brugada syndrome successfully treated by hydroquinidine therapy in a 3-year-old child. (16426410)	Probst V.... Le Marec H.	2006	SCN5A
21	A novel SCN5A mutation, F1344S, identified in a patient with Brugada syndrome and fever-induced ventricular fibrillation. (16616735)	Keller D.I.... Chahine M.	2006	SCN5A
22	Progressive cardiac conduction defect is the prevailing phenotype in carriers of a Brugada syndrome SCN5A mutation. (16643399)	Probst V.... Le Marec H.	2006	SCN5A
23	A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families. (15910881)	Smits J.P.... Wilde A.A.	2005	SCN5A
24	Novel Brugada syndrome-causing mutation in ion-conducting pore of cardiac Na+ channel does not affect ion selectivity properties. (16266370)	Amin A.S.... Tan H.L.	2005	SCN5A
25	Cryptic 5' splice site activation in SCN5A associated with Brugada syndrome. (15808832)	Hong K.... Brugada R.	2005	SCN5A
26	Brugada syndrome and fever: genetic and molecular characterization of patients carrying SCN5A mutations. (15890323)	Keller D.I.... Abriel H.	2005	SCN5A
27	A novel nonsense mutation in the SCN5A gene leads to Brugada syndrome and a silent gene mutation carrier state. (16239976)	Keller D.I.... Chahine M.	2005	SCN5A
28	A novel missense mutation in the SCN5A gene associated with Brugada syndrome bidirectionally affecting blocking actions of antiarrhythmic drugs. (15877619)	Itoh H.... Imoto K.	2005	SCN5A, PSMC4
29	Double SCN5A mutation underlying asymptomatic Brugada syndrome. (15851320)	Yokoi H.... Tsutsui H.	2005	SCN5A
30	Structural heart disease, SCN5A gene mutations, and Brugada syndrome: a complex mAcnage A trois. (16344397)	Saffitz J.E.	2005	SCN5A
31	Brugada syndrome (16001781)	Atarashi H.	2005	SCN5A
32	Phenotypic characterization of a large European family with Brugada syndrome displaying a sudden unexpected death syndrome mutation in SCN5A:. (15028074)	Hong K.... Brugada R.	2004	SCN5A
33	Single nucleotide polymorphisms of the SCN5A gene in Han Chinese and their relation with Brugada syndrome. (15161528)	Chen J.Z.... Guo X.G.	2004	SCN5A
34	PCR-based site-directed mutagenesis and recombinant expression plasmid construction of a SCN5A mutation (K317N) identified in a Chinese family with Brugada syndrome (14625171)	Yi S.D.... Peng J.	2003	SCN5A
35	Electrical alternans in long QT syndrome resembling a Brugada syndrome pattern. (14516346)	Schulze-Bahr E.... Borggrefe M.	2003	KCNQ1
36	Nucleotide changes in the translated region of SCN5A from Japanese patients with Brugada syndrome and control subjects. (12639704)	Takahata T.... Tateishi T.	2003	SCN5A
37	Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients. (12106943)	Smits J.P.P.... Wilde A.A.M.	2002	SCN5A
38	Novel mutations in domain I of SCN5A cause Brugada syndrome. (12051963)	Vatta M.... Towbin J.A.	2002	SCN5A
39	Brugada's syndrome: epidemiology, risk stratification, and clinical management (12407860)	Grillo M.... Priori S.G.	2002	SCN5A
40	Long QT syndrome and Brugada syndrome: 2 aspects of the same disease? (11307783)	Cerrone M.... Priori S.G.	2001	SCN5A
41	Possible bradycardic mode of death and successful pacemaker treatment in a large family with features of long QT syndrome type 3 and Brugada syndrome. (11405394)	Van Den Berg M.P.... Crijns H.J.	2001	SCN5A
42	Biophysical phenotypes of SCN5A mutations causing long QT and Brugada syndromes. (11150514)	Baroudi G.... Chahine M.	2000	SCN5A
43	Brugada syndrome without mutation of the cardiac sodium channel gene in a Taiwanese patient. (11155778)	Chen S.M.... Chiang F.T.	2000	SCN5A
44	SCN5A mutation (T1620M) causing Brugada syndrome exhibits different phenotypes when expressed in Xenopus oocytes and mammalian cells. (10664447)	Baroudi G.... Chahine M.	2000	SCN5A
45	Enhanced Na(+) channel intermediate inactivation in Brugada syndrome. (11029409)	Wang D.W.... George A.L.	2000	SCN5A
46	A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome. (10940383)	Akai J.... Hiraoka M.	2000	SCN5A
47	The elusive link between LQT3 and Brugada syndrome: t he role of flecainide challenge. (10961955)	Priori S.G.... Ronchetti E.	2000	SCN5A
48	Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent. (10532948)	Dumaine R.... Antzelevitch C.	1999	SCN5A
49	Transmural dispersion of repolarization and arrhythmogenicity: the Brugada syndrome versus the long QT syndrome. (10688320)	Antzelevitch C.... Shimizu W.	1999	SCN5A
50	Human SCN5A gene mutations alter cardiac sodium channel kinetics and are associated with the Brugada syndrome. (10690282)	Rook M.B.... Wilde A.A.M.	1999	SCN5A

Genes related to brugada syndrome according to GeneCards:

(show all 19)

id	Symbol	Description	Score	GeneCards Section Context
1	SCN1B	sodium channel, voltage-gated, type I, beta subunit	11.1	Publications, Summaries
2	GPD1L	glycerol-3-phosphate dehydrogenase 1-like	11.1	Summaries, Publications
3	SCN5A	sodium channel, voltage-gated, type V, alpha subunit	11.0	Publications
4	KCNE3	potassium voltage-gated channel, Isk-related family, member 3	11.0	Publications
5	SCN3B	sodium channel, voltage-gated, type III, beta subunit	11.0
6	HCN4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	11.0
7	KCNH2	potassium voltage-gated channel, subfamily H (eag-related), member 2	11.0	Publications
8	CACNB2	calcium channel, voltage-dependent, beta 2 subunit	11.0	Publications
9	CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	11.0	Publications
10	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	11.0	Publications
11	IRX6	iroquois homeobox 6	11.0	Publications
12	RANGRF	RAN guanine nucleotide release factor	11.0	Publications
13	GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	11.0	Publications
14	KCNE2	potassium voltage-gated channel, Isk-related family, member 2	11.0	Publications
15	KCNE1	potassium voltage-gated channel, Isk-related family, member 1	11.0	Publications
16	PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	11.0	Publications
17	PKP2	plakophilin 2	11.0	Publications
18	KCND3	potassium voltage-gated channel, Shal-related subfamily, member 3	11.0	Publications
19	KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	11.0	Publications

Pathways related to brugada syndrome according to GeneDecks:

(show all 14)

id	Pathway	Score	Top Affiliating Genes
1	Cholera Infection36	9.8	SCN1B, SCN5A, SCN3B
2	Axon guidance38	9.6	CACNA1C, CACNB2, SCN3B, SCN1B
3	Celecoxib Pathway, Pharmacodynamics34	9.6	KCNQ1, CACNB2, CACNA1C
4	Aldosterone Signaling in Epithelial Cells36	9.5	SCN1B, SCN5A, SCN3B
5	GHRH Signaling36	9.5	SCN1B, SCN5A, SCN3B, CACNB2, CACNA1C
6	PKA Signaling36	9.5	CACNA1C, CACNB2, SCN3B, SCN5A, SCN1B
7	Arrhythmogenic right ventricular cardiomyopathy (ARVC)20	9.4	CACNA1C, PKP2, CACNB2
8	Activation of cAMP-Dependent PKA36	9.3	SCN1B, SCN5A, SCN3B, CACNB2, CACNA1C
9	cAMP Pathway36	9.2	CACNA1C, CACNB2, SCN3B, SCN5A, SCN1B
10	Voltage gated Potassium channels38	9.1	KCNH2, KCNQ1, KCND3
11	Potassium transporters- outward current10	8.5	KCND3, KCNQ1, KCNH2, KCNE3, KCNE1
12	Potassium transporters- inward current10	INF	HCN4, , KCNH2, KCNE1
13	Antiarrhythmic Pathway, Pharmacodynamics34	INF	KCNE1, CACNA1C, HCN4, CACNB2, SCN3B, SCN5A
14	Dopamine-DARPP32 Feedback onto cAMP Pathway36	INF	CACNA1C, CACNB2, , KCNE2, KCND3, KCNQ1

Compounds related to brugada syndrome according to GeneDecks:

(show all 34)

id	Compound	Score	Top Affiliating Genes
1	flecainide32 34 9 9	13.3	SCN5A, KCNH2
2	propafenone32 34 9 9	13.3	KCNH2, SCN5A
3	mexiletine32 9 9	12.3	SCN5A, KCNH2
4	flecainide acetate42	10.2	SCN3B, SCN5A, SCN1B
5	ralfinamide mesylate42	10.2	SCN3B, SCN5A, SCN1B
6	qx 314 chloride42	10.2	SCN3B, SCN5A, SCN1B
7	Magnesium Sulfate9 9	11.2	CACNB2, CACNA1C
8	tetrodotoxin citrate42	10.2	SCN3B, SCN5A, SCN1B
9	vinpocetine32 42	11.2	SCN3B, SCN5A, SCN1B
10	ibutilide32 9 9	12.2	CACNA1C, KCNH2
11	zonisamide32 9 9	12.1	SCN1B, SCN5A, SCN3B
12	nisoldipine32 9 9	12.1	CACNA1C, CACNB2
13	clofilium32	10.0	KCNH2, KCNQ1
14	cisapride32 42 9 9	13.0	KCNH2, SCN5A
15	isradipine32 9 42 9	12.9	CACNB2, CACNA1C
16	chromanol32	9.8	KCNQ1, KCNE1
17	nilvadipine32 9 9	11.8	CACNA1C, CACNB2
18	verapamil32 34 9 18 9	13.8	KCNH2, SCN5A, CACNB2, CACNA1C
19	quinidine32 34 9 9	12.8	PSMC4, SCN5A, KCNH2
20	indapamide32 9 9	11.8	KCNQ1, KCNE1
21	bepridil32 9 9	11.8	KCNH2, KCNQ1
22	mibefradil32 9 9	11.8	CACNB2, PSMC4, CACNA1C
23	chromanol 293b42 32	10.7	KCNQ1, KCNE1
24	nimodipine32 9 42 9	12.6	CACNB2, CACNA1C
25	disopyramide32 9 9	11.6	SCN5A, KCND3
26	tetraethylammonium32	9.5	PSMC4, KCNQ1, KCNH2
27	isoleucine32	9.3	KCNH2, KCNQ1, SCN5A, PSMC4
28	kn-9342	9.0	KCNE1, KCNE3, KCND3, KCNE2
29	4-aminopyridine32 42	9.7	KCNE2, KCND3, KCNH2, KCNE3, KCNE1
30	am 92016 hydrochloride42	8.4	KCNE2, KCND3, KCNQ1, KCNE3, KCNE1
31	sodium32 18	8.5	SCN3B, ANK3, HCN4, PSMC4, SCN5A, SCN1B
32	calcium32 9 18 9	10.2	CACNA1C, PSMC4, CACNB2, GPD1, SCN5A, SCN1B
33	potassium32 9 18 9	INF	KCNE1, PSMC4, HCN4, SCN5A, SCN1B,
34	katp32	INF	KCNH2, KCNQ1,

Cellular components related to brugada syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	voltage-gated sodium channel complex	GO:001518	9.9	SCN1B, SCN5A, SCN3B
2	glycerol-3-phosphate dehydrogenase complex	GO:009331	9.9	GPD1L, GPD1
3	intercalated disc	GO:014704	9.6	ANK3, SCN5A, RANGRF
4	T-tubule	GO:030315	9.6	SCN5A, ANK3, CACNA1C
5	sarcolemma	GO:042383	INF	KCNQ1, KCND3, , SCN5A, ANK3, CACNB2
6	plasma membrane	GO:005886	INF	SCN3B, ANK3, PKP2, HCN4, CACNA1C, SCN5A
7	voltage-gated potassium channel complex	GO:008076	INF	, KCNE2, KCND3, KCNQ1, KCNH2, KCNE1

Biological processes related to brugada syndrome according to GeneDecks:

(show all 22)

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane depolarization involved in regulation of action potential	GO:086010	10.2	SCN5A, SCN3B
2	SA node cardiomyocyte to atrial cardiomyocyte communication	GO:086070	10.2	SCN5A, SCN3B
3	membrane depolarization involved in regulation of cardiac muscle cell action potential	GO:086012	10.2	SCN3B, SCN5A, SCN1B
4	regulation of ventricular cardiac muscle cell action potential	GO:086005	10.1	SCN3B, SCN5A
5	regulation of cardiac muscle cell action potential involved in contraction	GO:086002	10.1	SCN3B, SCN5A, SCN1B
6	glycerol-3-phosphate catabolic process	GO:046168	10.1	GPD1L, GPD1
7	regulation of atrial cardiomyocyte membrane depolarization	GO:060371	10.1	SCN3B, SCN5A, SCN1B
8	sodium ion transmembrane transport	GO:035725	10.1	SCN1B, SCN5A, SCN3B
9	regulation of ventricular cardiomyocyte membrane depolarization	GO:060373	10.0	SCN3B, SCN5A
10	cardiac muscle contraction	GO:060048	10.0	SCN3B, SCN5A, SCN1B
11	regulation of sodium ion transmembrane transporter activity	GO:2000649	10.0	RANGRF, SCN1B, SCN3B
12	regulation of ventricular cardiomyocyte membrane repolarization	GO:060307	10.0	SCN1B, SCN5A
13	regulation of heart rate by cardiac conduction	GO:086091	9.9	KCNH2, SCN1B, SCN5A, SCN3B
14	membrane depolarization	GO:051899	9.7	KCNE1, SCN1B, SCN5A, SCN3B
15	regulation of potassium ion transport	GO:043266	9.7	ANK3, KCNE3
16	potassium ion export	GO:071435	9.6	KCNQ1, KCNE1
17	axon guidance	GO:007411	9.5	SCN1B, SCN3B, CACNB2, CACNA1C
18	regulation of heart contraction	GO:008016	8.9	HCN4, KCNE2, KCNQ1, KCNH2, KCNE1
19	blood circulation	GO:008015	8.9	HCN4, KCNE2, KCNQ1, KCNH2, KCNE1
20	muscle contraction	GO:006936	8.9	HCN4, KCNE2, KCNQ1, KCNH2, KCNE1
21	synaptic transmission	GO:007268	INF	HCN4, CACNB2, SCN1B, , KCND3, KCNQ1
22	potassium ion transport	GO:006813	INF	, KCNE2, KCND3, KCNH2

Molecular functions related to brugada syndrome according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential	GO:086006	10.0	SCN3B, SCN5A, SCN1B
2	glycerol-3-phosphate dehydrogenase [NAD+] activity	GO:004367	9.8	GPD1L, GPD1
3	sodium channel regulator activity	GO:017080	9.8	RANGRF, SCN1B, SCN3B
4	voltage-gated sodium channel activity	GO:005248	9.7	SCN5A, SCN3B
5	ion channel binding	GO:044325	9.5	RANGRF, SCN5A, SCN3B, ANK3
6	potassium channel regulator activity	GO:015459	9.4	KCNE2, KCNE3, KCNE1
7	delayed rectifier potassium channel activity	GO:005251	9.4	KCNQ1, KCNH2, KCNE1
8	voltage-gated potassium channel activity	GO:005249	8.6	KCNE1, KCNE3, KCNH2, KCNQ1, KCNE2, HCN4
9	inward rectifier potassium channel activity	GO:005242	INF	KCNH2,