Bruxism malady

Wikipedia: Bruxism (from the Greek βρυγμός (brygmós), \"gnashing of teeth\") is characterized by the...⁴⁴ more...

MalaCards: Bruxism, also known as bruxism - teeth grinding, is related to attention deficit hyperactivity disorder and rett syndrome. An important gene associated with Bruxism is DRD2 (dopamine receptor D2).

Disease Ontology: A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping.⁶

Aliases & Descriptions:

bruxism 6 32 43 bruxism - teeth grinding 6 sleep related bruxism 6

teeth grinding 6 grinding teeth 6

Diseases related to bruxism by text searches and GeneDecks gene sharing:

id	Related Disease	Score	Top Affiliating Genes
1	attention deficit hyperactivity disorder	12.8	MECP2, DRD2
2	rett syndrome	12.8	MECP2, DRD2
3	growth mental deficiency syndrome of myhre	12.7	DRD2, MECP2
4	myoclonus	12.5	MECP2, DRD2
5	blindness	5.9

Approved drugs:

Drug clinical trials:

Articles related to bruxism:

id	Title	Authors	Year	Affiliating Genes
1	Double-blind, crossover, placebo-controlled trial of bromocriptine in patients with sleep bruxism. (11391125)	Lavigne G.J.... Montplaisir J.Y.	2001	DRD2
2	Striatal D2 receptor binding in sleep bruxism: a cont rolled study with iodine-123-iodobenzamide and single-photon-emission computed tomography. (8955676)	Lobbezoo F.... Lavigne G.J.	1996	DRD2

Genes related to bruxism according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	DRD2	dopamine receptor D2	11.0	Publications
2	MECP2	methyl CpG binding protein 2 (Rett syndrome)	11.0
3	DPM1	dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit	11.0
4	TMEM161B	transmembrane protein 161B	11.0
5	EBNA1BP2	EBNA1 binding protein 2	11.0
6	KLF7	Kruppel-like factor 7 (ubiquitous)	11.0
7	ADAM23	ADAM metallopeptidase domain 23	11.0
8	CEP70	centrosomal protein 70kDa	11.0

Biological processes related to bruxism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neurological system process involved in regulation of systemic arterial blood pressure	GO:001976	9.8	MECP2, DRD2
2	long-term memory	GO:007616	9.8	MECP2, DRD2
3	protein localization	GO:008104	9.8	MECP2, DRD2
4	visual learning	GO:008542	9.7	DRD2, MECP2
5	synapse assembly	GO:007416	9.5	MECP2, DRD2