MCID: BRX001
MIFTS: 49

Bruxism malady

Categories: Mental diseases, Oral diseases

Aliases & Classifications for Bruxism

Aliases & Descriptions for Bruxism:

Name: Bruxism 12 29 52 42 14 69
Sleep Bruxism 42 69
Bruxism - Teeth Grinding 12
Sleep Related Bruxism 12
Sleep-Related Bruxism 69
Grinding Teeth 12
Teeth Grinding 12

Classifications:



Summaries for Bruxism

Disease Ontology : 12 A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping.

MalaCards based summary : Bruxism, also known as sleep bruxism, is related to oromandibular dystonia and teratoma with malignant transformation, and has symptoms including sleep disturbances, toothache and teeth chattering. An important gene associated with Bruxism is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs Acetylcholine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and eye, and related phenotype is integument.

Wikipedia : 71 Bruxism is excessive teeth grinding or jaw clenching. It is an oral parafunctional activity; i.e., it is... more...

Related Diseases for Bruxism

Diseases related to Bruxism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Related Disease Score Top Affiliating Genes
1 oromandibular dystonia 10.8
2 teratoma with malignant transformation 10.2 DRD2 HTR2A
3 headache 10.2
4 intracranial cavernous angioma 10.1 DRD2 SLC6A4
5 cerebellar liponeurocytoma 10.1 HTR2A MECP2
6 allergic hypersensitivity disease 10.1 DRD2 HTR2A
7 ornithosis 10.1 DRD2 SLC6A4
8 vascular cancer 10.1 DRD2 HTR2A
9 apperceptive agnosia 10.1 DRD2 SLC6A4
10 colorectal adenocarcinoma 10.1 DRD2 SLC6A4
11 strongyloidiasis 10.1 DRD2 SLC6A4
12 interstitial emphysema 10.1 DRD2 SLC6A4
13 nephrogenic adenoma of the urethra 10.1 DRD2 SLC6A4
14 nephronophthisis 13 10.1 HTR2A SLC6A4
15 spinal meningioma 10.1 DRD2 HTR2A
16 dry eye syndrome 10.1 HTR2A SLC6A4
17 neurogenic bladder 10.0 HTR2A SLC6A4
18 intrahepatic gall duct cancer 10.0 HTR2A SLC6A4
19 sleep apnea 10.0
20 hypoglycemic coma 10.0 HTR2A SLC6A4
21 obstructive sleep apnea 10.0
22 cervicitis 10.0
23 multiple personality disorder 10.0 HTR2A SLC6A4
24 sleep disorder 10.0
25 primary angle-closure glaucoma 10.0 HTR2A SLC6A4
26 splenic abscess 10.0 DRD2 HTR2A SLC6A4
27 pyromania 10.0 DRD2 HTR2A SLC6A4
28 transmitted_by 10.0 DRD2 SLC6A4
29 waardenburg's syndrome 10.0 DRD2 HTR2A SLC6A4
30 cytomegalic congenital adrenal hypoplasia 10.0 DRD2 HTR2A SLC6A4
31 postencephalitic parkinson disease 10.0 DRD2 HTR2A SLC6A4
32 cecal benign neoplasm 9.9 DRD2 HTR2A SLC6A4
33 hereditary multiple exostoses 9.9 DRD2 HTR2A SLC6A4
34 hepatitis d 9.9 DRD2 HTR2A SLC6A4
35 retinoblastoma 9.9 DRD2 HTR2A SLC6A4
36 chronic conjunctivitis 9.9 DRD2 HTR2A SLC6A4
37 benign epilepsy with centrotemporal spikes 9.9 DRD2 HTR2A SLC6A4
38 bartter disease 9.9 HTR2A MECP2 SLC6A4
39 microcephaly 13, primary, autosomal recessive 9.9 DRD2 HTR2A SLC6A4
40 cerebritis 9.9
41 gastroesophageal reflux 9.9
42 cerebral palsy 9.9
43 brain glioblastoma multiforme 9.9 DRD2 HTR2A SLC6A4
44 hepatitis b reinfection following liver transplantation 9.9 HTR2A SLC6A4
45 keratosis 9.9 HTR2A SLC6A4
46 preeclampsia/eclampsia 5 9.9 DRD2 HTR2A SLC6A4
47 carotid stenosis 9.9 DRD2 SLC6A4
48 periodontitis 9.9
49 myoclonus 9.9
50 brain injury 9.9

Graphical network of the top 20 diseases related to Bruxism:



Diseases related to Bruxism

Symptoms & Phenotypes for Bruxism

UMLS symptoms related to Bruxism:


sleep disturbances, toothache, teeth chattering, mental and behavioral signs and symptoms, excessive daytime somnolence, sleeplessness

MGI Mouse Phenotypes related to Bruxism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 DRD2 FRRS1L KLF7 MECP2 SLC6A4

Drugs & Therapeutics for Bruxism

Drugs for Bruxism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 1 51-84-3 187
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3 abobotulinumtoxinA Phase 4,Phase 1
4 Botulinum Toxins Phase 4,Phase 1
5 Botulinum Toxins, Type A Phase 4,Phase 1
6 Cholinergic Agents Phase 4,Phase 1
7 incobotulinumtoxinA Phase 4,Phase 1
8 Neuromuscular Agents Phase 4,Phase 1
9 Neurotransmitter Agents Phase 4,Phase 1
10 onabotulinumtoxinA Phase 4,Phase 1
11 Peripheral Nervous System Agents Phase 4,Phase 1
12 Central Nervous System Depressants Phase 4
13 Anesthetics Phase 4
14 Anesthetics, Local Phase 4
15 Anti-Arrhythmia Agents Phase 4
16 Diuretics, Potassium Sparing Phase 4
17 Sodium Channel Blockers Phase 4
18
Salicylic acid Approved, Vet_approved Phase 3,Phase 1,Phase 2,Early Phase 1 69-72-7 338
19 Lemon Balm Nutraceutical Phase 3
20 Poke Nutraceutical Phase 3
21
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2,Early Phase 1 22916-47-8 4189
22 Antifungal Agents Phase 1, Phase 2,Early Phase 1
23 Anti-Infective Agents Phase 1, Phase 2,Early Phase 1
24 Dermatologic Agents Phase 1, Phase 2,Early Phase 1
25 Keratolytic Agents Phase 1, Phase 2,Early Phase 1
26
Buspirone Approved, Investigational 36505-84-7 2477
27
Clonidine Approved 4205-90-7 2803
28
Hydrocortisone Approved, Vet_approved Early Phase 1 50-23-7 5754 657311
29
Butyric Acid Experimental Early Phase 1 107-92-6 264
30 Pharmaceutical Solutions
31 Antidepressive Agents
32 Antimanic Agents
33 Lithium carbonate 554-13-2
34 Psychotropic Drugs
35 Tranquilizing Agents
36 Adrenergic Agents
37 Adrenergic Agonists
38 Adrenergic alpha-2 Receptor Agonists
39 Adrenergic alpha-Agonists
40 Analgesics
41 Anti-Anxiety Agents
42 Antihypertensive Agents
43 Autonomic Agents
44
Serotonin 50-67-9 5202
45 Serotonin Agents
46 Sympatholytics
47 Anti-Inflammatory Agents Early Phase 1
48 Cortisol succinate Early Phase 1
49 Hydrocortisone 17-butyrate 21-propionate Early Phase 1
50 Hydrocortisone acetate Early Phase 1

Interventional clinical trials:

(show all 35)
id Name Status NCT ID Phase
1 Study of the Safety and Efficacy of Botox in Bruxism Unknown status NCT00908050 Phase 4
2 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4
3 Nocturnal Mouth Guards, SOVA vs. Standard Acrylic Orthotic; Phase IV Completed NCT02340663 Phase 4
4 Oral Appliance in Obstructive Sleep Apnea. A Randomized Controlled Blinded Multicenter Study Comparing Two Devices Enrolling by invitation NCT02148510 Phase 4
5 Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques Terminated NCT00992108 Phase 4
6 Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial Completed NCT01268605 Phase 3
7 Efficacy of Phytolacca Decandra and Melissa Officinalis in Children With Nocturnal Bruxism Active, not recruiting NCT02870543 Phase 3
8 The Influence of Oral Vibrational Stimulation on Cognitive Function of Elderly Individuals Unknown status NCT02332525 Phase 1, Phase 2
9 Physiotherapy on the Airway of Bruxist Children Completed NCT01178229 Phase 1, Phase 2
10 Occlusal Adjustment as Treatment for Chronic Orofacial Pain Completed NCT00899717 Phase 1, Phase 2
11 Botox for Treatment of TMJ Disorder With Bruxism Unknown status NCT02202070 Phase 1
12 Relationship of Facial Pattern With Bruxism Unknown status NCT00868244
13 TMJ NextGen Pilot Study to Treat Subjects With Bruxism Unknown status NCT02446288
14 Reduction of Masticatory Muscle Activity by Restoring Canine Guidance Unknown status NCT02235220
15 Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea Unknown status NCT00520156
16 Respiratory Problems and Caries in Children With Bruxism Completed NCT01463826
17 Comparative Evaluation of Gabapentine and Occlusal Splint in the Management of Sleep Bruxism Completed NCT01255878
18 Treatment Sleep Bruxism With the Luco Hybrid OSA Appliance Completed NCT02882880
19 Floral Remedies for Sleep-bruxism Patients Completed NCT03112954
20 TMJ NextGeneration(TM) Feasibility Study Completed NCT02257320
21 Effects of the Continuous Wear of Invisalign® Trays on the Temporomandibular Joints and Orofacial Muscular Complex Completed NCT01812850
22 A Clinical Trial of the Optimal Treatment Period and Long-term Efficacy of Functional Electrical Stimulation (FES) on Sleep Bruxism Completed NCT01000389
23 Effects of Dry Needling in Patients With Sleep Bruxism and Temporomandibular Disorders: a Prospective Case Series Completed NCT02587182
24 Conservative Treatment of Patients With Temporomandibular Disorders Completed NCT01021306
25 Prevalence of Bruxism in a Group of Preschool Egyptian Children Recruiting NCT03006133
26 All-ceramic Crowns in Patients With Sleep Bruxism Recruiting NCT03039985
27 Sleep Bruxism and (Peri-)Implant Complications Recruiting NCT02410681
28 Restoring Masticatory Function to Treat Chronic Pain Recruiting NCT02144233
29 Physical Therapy Interventions Relative to Dental Treatment in Individuals With Bruxism Active, not recruiting NCT01778881
30 Evaluation of Selected Disorders With Sleep Bruxism Enrolling by invitation NCT03083405
31 Evaluation of Muscle Activity, Bite Force and Salivary Cortisol in Children With Bruxism Not yet recruiting NCT02757261 Early Phase 1
32 Clinical Efficacy of Crowns Fabricated Using LuxaCrown Not yet recruiting NCT03160950
33 Treatment Period and Long-term Efficacy of Functional Electrical Stimulation (FES) on Sleep Bruxism Terminated NCT01005511
34 Treatment Period and Long-term Effect of Functional Electric Stimulation (FES) for Bruxism Terminated NCT00807430
35 TMJ-1001 Bruxism Run-In/Pivotal Trial Withdrawn NCT02269553

Search NIH Clinical Center for Bruxism

Cochrane evidence based reviews: bruxism

Genetic Tests for Bruxism

Genetic tests related to Bruxism:

id Genetic test Affiliating Genes
1 Bruxism 29

Anatomical Context for Bruxism

MalaCards organs/tissues related to Bruxism:

39
Brain, Bone, Eye, Testes, Heart, Kidney, Pineal

Publications for Bruxism

Articles related to Bruxism:

(show top 50) (show all 609)
id Title Authors Year
1
Sleep and awake bruxism in adults and its relationship with temporomandibular disorders: A systematic review from 2003 to 2014. ( 27796166 )
2017
2
Relationship between obstructive sleep apnoea syndrome and sleep bruxism: a systematic review. ( 27977045 )
2017
3
Therapies for bruxism: a systematic review and network meta-analysis (protocol). ( 28086992 )
2017
4
Brexism and bruxism. ( 27982009 )
2016
5
Dentists' knowledge of occlusal splint therapy for bruxism and temporomandibular joint disorders. ( 27251967 )
2016
6
Short-term effects of repetitive transcranial magnetic stimulation on sleep bruxism - a pilot study. ( 27025267 )
2016
7
Error in Calculation of Predictive Values in Paper on Screening for Sleep Bruxism. ( 26888593 )
2016
8
Cross-sectional study of anxiety symptoms and self-report of awake and sleep bruxism in female TMD patients. ( 27097685 )
2016
9
A randomised, open-label, crossover study of the dopamine agonist, pramipexole, in patients with sleep bruxism. ( 27426276 )
2016
10
Methadone maintenance treatment may be associated with bruxism in male prisoners. ( 27855842 )
2016
11
Association between patterns of jaw motor activity during sleep and clinical signs and symptoms of sleep bruxism. ( 27996170 )
2016
12
Correction to To see bruxism: a functional MRI study. ( 26975898 )
2016
13
Self-Reported Bruxism and Symptoms of Temporomandibular Disorders in Finnish University Students. ( 27792798 )
2016
14
Botulinum Toxin Type A as Preoperative Treatment for Immediately Loaded Dental Implants Placed in Fresh Extraction Sockets for Full-Arch Restoration of Patients With Bruxism. ( 27092916 )
2016
15
Sleep bruxism: challenges and restorative solutions. ( 27217798 )
2016
16
Current Treatments of Bruxism. ( 26897026 )
2016
17
Bruxism is a continuously distributed behaviour, but disorder decisions are dichotomous (Response to letter by Manfredini, De Laat, Winocur, & Ahlberg (2016)). ( 27558868 )
2016
18
Sleep bruxism associated with obstructive sleep apnoea syndrome - A pilot study using a new portable device. ( 27567051 )
2016
19
Grinding patterns in migraine patients with sleep bruxism: a case-controlled study. ( 27077249 )
2016
20
Impact of Bruxism on Ceramic Defects in Implant-Borne Fixed Dental Prostheses: A Retrospective Study. ( 27148995 )
2016
21
The Association between Headaches and Temporomandibular Disorders is Confounded by Bruxism and Somatic Complaints. ( 28002094 )
2016
22
Intricate Assessment and Evaluation of Effect of Bruxism on Long-term Survival and Failure of Dental Implants: A Comparative Study. ( 27659086 )
2016
23
Generation of neural cells using iPSCs from sleep bruxism patients with 5-HT2A polymorphism. ( 27916472 )
2016
24
Bruxism and dental implant failures: a multilevel mixed effects parametric survival analysis approach. ( 27611304 )
2016
25
A survey on the potential relationships between TMD, possible sleep bruxism, unilateral chewing, and occlusal factors in Turkish university students. ( 27707365 )
2016
26
Different association between specific manifestations of bruxism and temporomandibular disorder pain. ( 27687043 )
2016
27
Perceived stress and bruxism in university students. ( 28003024 )
2016
28
Sleep bruxism is related to decreased inhibitory control of trigeminal motoneurons, but not with reticulobulbar system. ( 27629540 )
2016
29
Effect of mandibular advancement device on sleep bruxism score and sleep quality. ( 27422230 )
2016
30
Bruxism and dental implant treatment complications: a retrospective comparative study of 98 bruxer patients and a matched group. ( 27009853 )
2016
31
Effects of myofascial trigger point dry needling in patients with sleep bruxism and temporomandibular disorders: a prospective case series. ( 27697769 )
2016
32
Diagnostic validity of self-reported measures of sleep bruxism using an ambulatory single-channel EMG device. ( 26876908 )
2016
33
Association between Self-Reported Bruxism and Sleeping Patterns among Dental Students in Saudi Arabia: A Cross-Sectional Study. ( 27034672 )
2016
34
BruxApp: the ecological momentary assessment of awake bruxism. ( 27374364 )
2016
35
Prosthodontic planning in patients with temporomandibular disorders and/or bruxism: A systematic review. ( 27836142 )
2016
36
A Case of Bruxism-Induced Otalgia. ( 27626088 )
2016
37
Five Things to Know About Sleep Bruxism. ( 27159944 )
2016
38
Associations of sleep bruxism with age, sleep apnea and daytime problematic behaviors in children. ( 27087630 )
2016
39
Bruxism in Movement Disorders: A Comprehensive Review. ( 27077925 )
2016
40
Why not stop looking at bruxism as a black/white condition? Aetiology could be unrelated to clinical consequences. ( 27545318 )
2016
41
Self-Reported bruxism and associated factors in Israeli adolescents. ( 26968152 )
2016
42
Evaluation of a Proton Pump Inhibitor for Sleep Bruxism: A Randomized Clinical Trial. ( 27474257 )
2016
43
Genetic polymorphisms in the serotonergic system are associated with circadian manifestations of bruxism. ( 27611726 )
2016
44
Diagnostic accuracy of the use of parental-reported sleep bruxism in a polysomnographic study in children. ( 27612328 )
2016
45
Diagnosis of sleep bruxism can assist in the detection of cases of verbal school bullying and measure the life satisfaction of adolescents. ( 27598528 )
2016
46
Association between sleep bruxism and alcohol, caffeine, tobacco, and drug abuse: A systematic review. ( 27522154 )
2016
47
Sleep Bruxism-Tooth Grinding Prevalence, Characteristics and Familial Aggregation: A Large Cross-Sectional Survey and Polysomnographic Validation. ( 27568807 )
2016
48
Sleep bruxism in children: sleep studies correlate poorly with parental reports. ( 27198949 )
2016
49
Association between possible sleep bruxism and sleep characteristics in children. ( 27691903 )
2016
50
Evaluation of electromyographic signals in children with bruxism before and after therapy with Melissa Officinalis L-a randomized controlled clinical trial. ( 27134350 )
2016

Variations for Bruxism

Expression for Bruxism

Search GEO for disease gene expression data for Bruxism.

Pathways for Bruxism

Pathways related to Bruxism according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.01 HTR2A MECP2 SLC6A4
2 10.4 HTR2A SLC6A4

GO Terms for Bruxism

Biological processes related to Bruxism according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.7 DRD2 HTR2A SLC6A4
2 response to hypoxia GO:0001666 9.61 DRD2 MECP2 SLC6A4
3 protein localization GO:0008104 9.56 DRD2 MECP2
4 synapse assembly GO:0007416 9.55 DRD2 MECP2
5 sensory perception of pain GO:0019233 9.54 HTR2A MECP2
6 social behavior GO:0035176 9.51 MECP2 SLC6A4
7 visual learning GO:0008542 9.49 DRD2 MECP2
8 release of sequestered calcium ion into cytosol GO:0051209 9.48 DRD2 HTR2A
9 long-term memory GO:0007616 9.46 DRD2 MECP2
10 regulation of dopamine secretion GO:0014059 9.4 DRD2 HTR2A
11 temperature homeostasis GO:0001659 9.37 DRD2 HTR2A
12 behavioral response to cocaine GO:0048148 9.32 DRD2 HTR2A
13 startle response GO:0001964 9.26 DRD2 MECP2
14 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.16 DRD2 HTR2A
15 memory GO:0007613 9.13 HTR2A MECP2 SLC6A4
16 neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 8.62 DRD2 MECP2

Sources for Bruxism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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