Aliases & Classifications for Bruxism

MalaCards integrated aliases for Bruxism:

Name: Bruxism 12 29 52 42 14 69
Sleep Bruxism 42 69
Bruxism - Teeth Grinding 12
Sleep Related Bruxism 12
Sleep-Related Bruxism 69
Grinding Teeth 12
Teeth Grinding 12

Classifications:



Summaries for Bruxism

Disease Ontology : 12 A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping.

MalaCards based summary : Bruxism, also known as sleep bruxism, is related to oromandibular dystonia and teebi kaurah syndrome, and has symptoms including sleep disturbances, toothache and teeth chattering. An important gene associated with Bruxism is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs Acetylcholine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and eye.

Wikipedia : 72 Bruxism is excessive teeth grinding or jaw clenching. It is an oral parafunctional activity; i.e., it is... more...

Related Diseases for Bruxism

Diseases related to Bruxism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
id Related Disease Score Top Affiliating Genes
1 oromandibular dystonia 10.8
2 teebi kaurah syndrome 10.4 DRD2 HTR2A
3 contact dermatitis 10.4 DRD2 HTR2A
4 allergic hypersensitivity disease 10.4 DRD2 HTR2A
5 vascular cancer 10.4 DRD2 HTR2A
6 ceruminous carcinoma 10.3 HTR2A MECP2
7 intracranial cavernous angioma 10.3 DRD2 SLC6A4
8 ornithosis 10.3 DRD2 SLC6A4
9 anosognosia 10.3 DRD2 SLC6A4
10 hemorrhagic cystitis 10.3 DRD2 SLC6A4
11 spinal meningioma 10.3 DRD2 HTR2A
12 tongue disease 10.3 DRD2 SLC6A4
13 bladder hepatoid adenocarcinoma 10.2 DRD2 SLC6A4
14 spinocerebellar degeneration 10.2 FRRS1L MECP2
15 pelvic inflammatory disease 10.2 DRD2 SLC6A4
16 suppurative periapical periodontitis 10.2 DRD2 SLC6A4
17 headache 10.2
18 conjunctival degeneration 10.1 HTR2A SLC6A4
19 acute female pelvic peritonitis 10.1 DRD2 SLC6A4
20 neurogenic bladder 10.1 HTR2A SLC6A4
21 carotid stenosis 10.1 DRD2 SLC6A4
22 intrahepatic gall duct cancer 10.1 HTR2A SLC6A4
23 obsessive-compulsive personality disorder 10.0 HTR2A SLC6A4
24 sleep apnea 10.0
25 acquired aneurysmal subarachnoid hemorrhage 10.0 HTR2A SLC6A4
26 obstructive sleep apnea 10.0
27 cervicitis 10.0
28 primary angle-closure glaucoma 10.0 HTR2A SLC6A4
29 sleep disorder 10.0
30 keratosis 9.9 HTR2A SLC6A4
31 gastroesophageal reflux 9.9
32 cerebral palsy 9.9
33 cerebritis 9.9
34 colon mucinous adenocarcinoma 9.9 DRD2 SLC6A4
35 alcoholic liver cirrhosis 9.9 DRD2 SLC6A4
36 laryngeal adductor paralysis 9.9 HTR2A SLC6A4
37 myoclonus 9.9
38 brain injury 9.9
39 periodontitis 9.9
40 splenic abscess 9.8 DRD2 HTR2A SLC6A4
41 pompholyx 9.8 DRD2 HTR2A SLC6A4
42 pyromania 9.8 DRD2 HTR2A SLC6A4
43 pauci-immune glomerulonephritis with anca 9.8 DRD2 HTR2A SLC6A4
44 postencephalitic parkinson disease 9.8 DRD2 HTR2A SLC6A4
45 cecal benign neoplasm 9.8 DRD2 HTR2A SLC6A4
46 hypoglycemic coma 9.8 HTR2A SLC6A4
47 hereditary multiple exostoses 9.8 DRD2 HTR2A SLC6A4
48 bladder flat intraepithelial lesion 9.8 DRD2 HTR2A SLC6A4
49 hepatitis d 9.8 DRD2 HTR2A SLC6A4
50 chronic conjunctivitis 9.8 DRD2 HTR2A SLC6A4

Graphical network of the top 20 diseases related to Bruxism:



Diseases related to Bruxism

Symptoms & Phenotypes for Bruxism

UMLS symptoms related to Bruxism:


sleep disturbances, toothache, teeth chattering, mental and behavioral signs and symptoms, excessive daytime somnolence, sleeplessness

Drugs & Therapeutics for Bruxism

Drugs for Bruxism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 1 51-84-3 187
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3 abobotulinumtoxinA Phase 4,Phase 1
4 Botulinum Toxins Phase 4,Phase 1
5 Botulinum Toxins, Type A Phase 4,Phase 1
6 Cholinergic Agents Phase 4,Phase 1
7 Neuromuscular Agents Phase 4,Phase 1
8 Neurotransmitter Agents Phase 4,Phase 1
9 onabotulinumtoxinA Phase 4,Phase 1
10 Peripheral Nervous System Agents Phase 4,Phase 1
11 Central Nervous System Depressants Phase 4
12 Anesthetics Phase 4
13 Anesthetics, Local Phase 4
14 Anti-Arrhythmia Agents Phase 4
15 Diuretics, Potassium Sparing Phase 4
16 Sodium Channel Blockers Phase 4
17
Salicylic acid Approved, Vet_approved Phase 3,Phase 1,Phase 2,Early Phase 1 69-72-7 338
18 Lemon Balm Nutraceutical Phase 3
19 Poke Nutraceutical Phase 3
20
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2,Early Phase 1 22916-47-8 4189
21 Antifungal Agents Phase 1, Phase 2,Early Phase 1
22 Anti-Infective Agents Phase 1, Phase 2,Early Phase 1
23 Dermatologic Agents Phase 1, Phase 2,Early Phase 1
24 Keratolytic Agents Phase 1, Phase 2,Early Phase 1
25
Gabapentin Approved, Investigational 60142-96-3 3446
26
Buspirone Approved, Investigational 36505-84-7 2477
27
Clonidine Approved 4205-90-7 2803
28
Hydrocortisone Approved, Vet_approved Early Phase 1 50-23-7 5754 657311
29
gamma-Aminobutyric acid Investigational 56-12-2 119
30
Butyric Acid Experimental Early Phase 1 107-92-6 264
31 Analgesics
32 Anti-Anxiety Agents
33 Anticonvulsants
34 Antimanic Agents
35 Antiparkinson Agents
36 calcium channel blockers
37 Calcium, Dietary
38 Excitatory Amino Acid Antagonists
39 Excitatory Amino Acids
40 GABA Agents
41 Psychotropic Drugs
42 Tranquilizing Agents
43 Pharmaceutical Solutions
44 Antidepressive Agents
45 Lithium carbonate 554-13-2
46 Adrenergic Agents
47 Adrenergic Agonists
48 Adrenergic alpha-2 Receptor Agonists
49 Adrenergic alpha-Agonists
50 Antihypertensive Agents

Interventional clinical trials:

(show all 35)

id Name Status NCT ID Phase Drugs
1 Study of the Safety and Efficacy of Botox in Bruxism Unknown status NCT00908050 Phase 4 Botulinum toxin type A
2 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
3 Nocturnal Mouth Guards, SOVA vs. Standard Acrylic Orthotic; Phase IV Completed NCT02340663 Phase 4
4 Oral Appliance in Obstructive Sleep Apnea. A Randomized Controlled Blinded Multicenter Study Comparing Two Devices Enrolling by invitation NCT02148510 Phase 4
5 Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques Terminated NCT00992108 Phase 4 lidocaine;chemodenervation
6 Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial Completed NCT01268605 Phase 3
7 Efficacy of Phytolacca Decandra and Melissa Officinalis in Children With Nocturnal Bruxism Active, not recruiting NCT02870543 Phase 3 Phytolacca decandra;Melissa officinalis;Phyt.decandra + Melissa offic.
8 The Influence of Oral Vibrational Stimulation on Cognitive Function of Elderly Individuals Unknown status NCT02332525 Phase 1, Phase 2
9 Physiotherapy on the Airway of Bruxist Children Completed NCT01178229 Phase 1, Phase 2
10 Occlusal Adjustment as Treatment for Chronic Orofacial Pain Completed NCT00899717 Phase 1, Phase 2
11 Botox for Treatment of TMJ Disorder With Bruxism Unknown status NCT02202070 Phase 1 onabotulinumtoxinA
12 Relationship of Facial Pattern With Bruxism Unknown status NCT00868244
13 TMJ NextGen Pilot Study to Treat Subjects With Bruxism Unknown status NCT02446288
14 Reduction of Masticatory Muscle Activity by Restoring Canine Guidance Unknown status NCT02235220
15 Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea Unknown status NCT00520156
16 Respiratory Problems and Caries in Children With Bruxism Completed NCT01463826
17 Comparative Evaluation of Gabapentine and Occlusal Splint in the Management of Sleep Bruxism Completed NCT01255878 Gabapentine
18 Treatment Sleep Bruxism With the Luco Hybrid OSA Appliance Completed NCT02882880
19 Floral Remedies for Sleep-bruxism Patients Completed NCT03112954 Buccal-relaxant formula;Placebo
20 TMJ NextGeneration(TM) Feasibility Study Completed NCT02257320
21 Effects of the Continuous Wear of Invisalign® Trays on the Temporomandibular Joints and Orofacial Muscular Complex Completed NCT01812850
22 A Clinical Trial of the Optimal Treatment Period and Long-term Efficacy of Functional Electrical Stimulation (FES) on Sleep Bruxism Completed NCT01000389
23 Effects of Dry Needling in Patients With Sleep Bruxism and Temporomandibular Disorders: a Prospective Case Series Completed NCT02587182
24 Conservative Treatment of Patients With Temporomandibular Disorders Completed NCT01021306
25 Prevalence of Bruxism in a Group of Preschool Egyptian Children Recruiting NCT03006133
26 All-ceramic Crowns in Patients With Sleep Bruxism Recruiting NCT03039985
27 Sleep Bruxism and (Peri-)Implant Complications Recruiting NCT02410681
28 Restoring Masticatory Function to Treat Chronic Pain Recruiting NCT02144233
29 Physical Therapy Interventions Relative to Dental Treatment in Individuals With Bruxism Active, not recruiting NCT01778881
30 Evaluation of Selected Disorders With Sleep Bruxism Enrolling by invitation NCT03083405 Clonidine;Buspirone
31 Evaluation of Muscle Activity, Bite Force and Salivary Cortisol in Children With Bruxism Not yet recruiting NCT02757261 Early Phase 1
32 Clinical Efficacy of Crowns Fabricated Using LuxaCrown Not yet recruiting NCT03160950
33 Treatment Period and Long-term Efficacy of Functional Electrical Stimulation (FES) on Sleep Bruxism Terminated NCT01005511
34 Treatment Period and Long-term Effect of Functional Electric Stimulation (FES) for Bruxism Terminated NCT00807430
35 TMJ-1001 Bruxism Run-In/Pivotal Trial Withdrawn NCT02269553

Search NIH Clinical Center for Bruxism

Cochrane evidence based reviews: bruxism

Genetic Tests for Bruxism

Genetic tests related to Bruxism:

id Genetic test Affiliating Genes
1 Bruxism 29

Anatomical Context for Bruxism

MalaCards organs/tissues related to Bruxism:

39
Brain, Bone, Eye, Testes, Heart, Kidney, Pineal

Publications for Bruxism

Articles related to Bruxism:

(show top 50) (show all 629)
id Title Authors Year
1
Nocturnal sleep architecture is altered by sleep bruxism. ( 28883558 )
2017
2
Oral appliances for managing sleep bruxism in adults: a systematic review from 2007 to 2017. ( 28859236 )
2017
3
Relationship between obstructive sleep apnoea syndrome and sleep bruxism: a systematic review. ( 27977045 )
2017
4
Sleep bruxism and related risk factors in adults: A systematic literature review. ( 28692828 )
2017
5
Prevalence of bruxism and temporomandibular disorders among orphans in southeast Uganda: A gender and age comparison. ( 28555521 )
2017
6
The Evaluation of the Clinical Effects of Botulinum Toxin on Nocturnal Bruxism. ( 28757802 )
2017
7
The effects of stabilization splint treatment on the volume of masseter muscle in sleep bruxism patients. ( 28920539 )
2017
8
Personality traits and dental anxiety in self-reported bruxism. A cross-sectional study. ( 28684309 )
2017
9
The clinical management of awake bruxism. ( 28550845 )
2017
10
Success Rate and Technical Quality of Home Polysomnography with Self-Applicable Electrode Set in Subjects with Possible Sleep Bruxism. ( 28829322 )
2017
11
Aesthetic Treatment of Bruxism. ( 28670358 )
2017
12
Current Concepts of Bruxism. ( 28806429 )
2017
13
Decreased GABA Levels in the Brainstem in Patients with Possible Sleep Bruxism: A Pilot Study. ( 28891592 )
2017
14
Evaluation of muscle activity, bite force and salivary cortisol in children with bruxism before and after low level laser applied to acupoints: study protocol for a randomised controlled trial. ( 28789647 )
2017
15
Companion of oral movements with limb movements in patients with sleep bruxism: preliminary findings. ( 28735914 )
2017
16
Effect of interocclusal appliance on bite force, sleep quality, salivary cortisol levels and signs and symptoms of temporomandibular dysfunction in adults with sleep bruxism. ( 28601734 )
2017
17
Proton pump inhibitor shows no convincing evidence of efficacy for treating sleep bruxism. ( 28550850 )
2017
18
No convincing evidence of an association between young mothers' psychological traits and sleep bruxism in toddlers. ( 28550852 )
2017
19
Homeopathic therapy for sleep bruxism in a child: Findings of a 2-year case report. ( 28914254 )
2017
20
Therapies for bruxism: a systematic review and network meta-analysis (protocol). ( 28086992 )
2017
21
Sleep behaviors in children with different frequencies of parental-reported sleep bruxism. ( 28807776 )
2017
22
Sleep and awake bruxism in adults and its relationship with temporomandibular disorders: A systematic review from 2003 to 2014. ( 27796166 )
2017
23
Prosthodontic planning in patients with temporomandibular disorders and/or bruxism: a systematic review. ( 28798446 )
2017
24
Association between proxy-reported sleep bruxism and quality of life aspects in Colombian children of different social layers. ( 27417100 )
2016
25
A randomised, open-label, crossover study of the dopamine agonist, pramipexole, in patients with sleep bruxism. ( 27426276 )
2016
26
A survey on the potential relationships between TMD, possible sleep bruxism, unilateral chewing, and occlusal factors in Turkish university students. ( 27707365 )
2016
27
Association between sleep bruxism and alcohol, caffeine, tobacco, and drug abuse: A systematic review. ( 27522154 )
2016
28
Methadone treatment, bruxism, and temporomandibular disorders among male prisoners. ( 27041534 )
2016
29
Diagnosis of sleep bruxism can assist in the detection of cases of verbal school bullying and measure the life satisfaction of adolescents. ( 27598528 )
2016
30
Five Things to Know About Sleep Bruxism. ( 27159944 )
2016
31
Effects of myofascial trigger point dry needling in patients with sleep bruxism and temporomandibular disorders: a prospective case series. ( 27697769 )
2016
32
Bruxism in Movement Disorders: A Comprehensive Review. ( 27077925 )
2016
33
Correction to To see bruxism: a functional MRI study. ( 26975898 )
2016
34
Association between Self-Reported Bruxism and Sleeping Patterns among Dental Students in Saudi Arabia: A Cross-Sectional Study. ( 27034672 )
2016
35
Cross-sectional study of anxiety symptoms and self-report of awake and sleep bruxism in female TMD patients. ( 27097685 )
2016
36
BruxApp: the ecological momentary assessment of awake bruxism. ( 27374364 )
2016
37
Sleep bruxism: challenges and restorative solutions. ( 27217798 )
2016
38
Impact of sleep bruxism on masseter and temporalis muscles and bite force. ( 27077268 )
2016
39
The Association between Headaches and Temporomandibular Disorders is Confounded by Bruxism and Somatic Complaints. ( 28002094 )
2016
40
Association between possible sleep bruxism and sleep characteristics in children. ( 27691903 )
2016
41
Intricate Assessment and Evaluation of Effect of Bruxism on Long-term Survival and Failure of Dental Implants: A Comparative Study. ( 27659086 )
2016
42
Botulinum Toxin Type A as Preoperative Treatment for Immediately Loaded Dental Implants Placed in Fresh Extraction Sockets for Full-Arch Restoration of Patients With Bruxism. ( 27092916 )
2016
43
Self-Reported bruxism and associated factors in Israeli adolescents. ( 26968152 )
2016
44
Short-term effects of repetitive transcranial magnetic stimulation on sleep bruxism - a pilot study. ( 27025267 )
2016
45
Sleep Bruxism-Tooth Grinding Prevalence, Characteristics and Familial Aggregation: A Large Cross-Sectional Survey and Polysomnographic Validation. ( 27568807 )
2016
46
Effect of mandibular advancement device on sleep bruxism score and sleep quality. ( 27422230 )
2016
47
Sleep bruxism in children: sleep studies correlate poorly with parental reports. ( 27198949 )
2016
48
Perceived stress and bruxism in university students. ( 28003024 )
2016
49
Sleep bruxism: Current knowledge and contemporary management. ( 27656052 )
2016
50
Associations of sleep bruxism with age, sleep apnea and daytime problematic behaviors in children. ( 27087630 )
2016

Variations for Bruxism

Expression for Bruxism

Search GEO for disease gene expression data for Bruxism.

Pathways for Bruxism

Pathways related to Bruxism according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.01 HTR2A MECP2 SLC6A4
2 10.4 HTR2A SLC6A4

GO Terms for Bruxism

Biological processes related to Bruxism according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.71 DRD2 HTR2A SLC6A4
2 protein localization GO:0008104 9.56 DRD2 MECP2
3 synapse assembly GO:0007416 9.55 DRD2 MECP2
4 response to hypoxia GO:0001666 9.54 DRD2 MECP2 SLC6A4
5 sensory perception of pain GO:0019233 9.52 HTR2A MECP2
6 social behavior GO:0035176 9.51 MECP2 SLC6A4
7 visual learning GO:0008542 9.49 DRD2 MECP2
8 release of sequestered calcium ion into cytosol GO:0051209 9.48 DRD2 HTR2A
9 long-term memory GO:0007616 9.46 DRD2 MECP2
10 regulation of dopamine secretion GO:0014059 9.43 DRD2 HTR2A
11 behavioral response to cocaine GO:0048148 9.4 DRD2 HTR2A
12 temperature homeostasis GO:0001659 9.32 DRD2 HTR2A
13 startle response GO:0001964 9.26 DRD2 MECP2
14 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.16 DRD2 HTR2A
15 memory GO:0007613 9.13 HTR2A MECP2 SLC6A4
16 neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 8.62 DRD2 MECP2

Sources for Bruxism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....