Aliases & Classifications for Bruxism

MalaCards integrated aliases for Bruxism:

Name: Bruxism 12 28 51 41 14 69
Sleep Bruxism 41 69
Bruxism - Teeth Grinding 12
Sleep Related Bruxism 12
Sleep-Related Bruxism 69
Grinding Teeth 12
Teeth Grinding 12

Classifications:



Summaries for Bruxism

Disease Ontology : 12 A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping.

MalaCards based summary : Bruxism, also known as sleep bruxism, is related to migraine with or without aura 1 and social phobia, and has symptoms including sleeplessness, excessive daytime somnolence and mental and behavioral signs and symptoms. An important gene associated with Bruxism is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs Acetylcholine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and bone.

Wikipedia : 72 Bruxism is excessive teeth grinding or jaw clenching. It is an oral parafunctional activity; i.e., it is... more...

Related Diseases for Bruxism

Diseases related to Bruxism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 30.1 DRD2 HTR2A SLC6A4
2 social phobia 29.9 DRD2 SLC6A4
3 autism 29.5 DRD2 HTR2A MECP2 SLC6A4
4 attention deficit-hyperactivity disorder 29.2 DRD2 HTR2A MECP2 SLC6A4
5 parasomnia, sleep bruxism type 12.3
6 oromandibular dystonia 10.9
7 tardive dyskinesia 10.4 DRD2 HTR2A
8 tic disorder 10.4 DRD2 HTR2A
9 drug-induced mental disorder 10.4 DRD2 HTR2A
10 drug psychosis 10.4 DRD2 HTR2A
11 episodic pain syndrome, familial, 1 10.4
12 progressive multifocal leukoencephalopathy 10.3 HTR2A MECP2
13 alcohol use disorder 10.3 DRD2 SLC6A4
14 alcohol-induced mental disorder 10.3 DRD2 SLC6A4
15 alzheimer disease 5 10.3 HTR2A SLC6A4
16 megacolon 10.3 DRD2 HTR2A
17 headache 10.3
18 oppositional defiant disorder 10.3 DRD2 SLC6A4
19 psychosexual disorder 10.3 HTR2A SLC6A4
20 alexithymia 10.3 DRD2 SLC6A4
21 dysthymic disorder 10.3 HTR2A SLC6A4
22 antisocial personality disorder 10.2 DRD2 SLC6A4
23 tibial muscular dystrophy, tardive 10.2
24 migraine without aura 10.2 DRD2 SLC6A4
25 paranoid schizophrenia 10.2 HTR2A SLC6A4
26 opiate dependence 10.2 DRD2 SLC6A4
27 borderline personality disorder 10.2 HTR2A SLC6A4
28 cocaine abuse 10.2 DRD2 SLC6A4
29 serotonin syndrome 10.2 HTR2A SLC6A4
30 bipolar i disorder 10.1 HTR2A SLC6A4
31 anxiety 10.1
32 mental depression 10.1 HTR2A SLC6A4
33 sleep apnea 10.1
34 cocaine dependence 10.1 DRD2 SLC6A4
35 apnea, obstructive sleep 10.1
36 cervicitis 10.1
37 alcoholic psychosis 10.1 DRD2 HTR2A SLC6A4
38 periodic limb movement disorder 10.1 DRD2 HTR2A SLC6A4
39 pathological gambling 10.1 DRD2 HTR2A SLC6A4
40 bulimia nervosa 1 10.1 HTR2A SLC6A4
41 early-onset schizophrenia 10.1 DRD2 HTR2A SLC6A4
42 generalized anxiety disorder 10.1 DRD2 HTR2A SLC6A4
43 personality disorder 10.1 DRD2 HTR2A SLC6A4
44 post-traumatic stress disorder 10.1 DRD2 HTR2A SLC6A4
45 schizoaffective disorder 10.1 DRD2 HTR2A SLC6A4
46 conduct disorder 10.1 DRD2 SLC6A4
47 mood disorder 10.1 DRD2 HTR2A SLC6A4
48 sleep disorder 10.0
49 psychotic disorder 10.0 DRD2 HTR2A SLC6A4
50 obsessive-compulsive disorder 10.0 DRD2 HTR2A SLC6A4

Graphical network of the top 20 diseases related to Bruxism:



Diseases related to Bruxism

Symptoms & Phenotypes for Bruxism

UMLS symptoms related to Bruxism:


sleeplessness, excessive daytime somnolence, mental and behavioral signs and symptoms, teeth chattering, toothache, snoring, sleep disturbances

Drugs & Therapeutics for Bruxism

Drugs for Bruxism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 1 51-84-3 187
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3 abobotulinumtoxinA Phase 4,Phase 1
4 Botulinum Toxins Phase 4,Phase 1
5 Botulinum Toxins, Type A Phase 4,Phase 1
6 Cholinergic Agents Phase 4,Phase 1
7 Neuromuscular Agents Phase 4,Phase 1
8 Neurotransmitter Agents Phase 4,Phase 1
9 onabotulinumtoxinA Phase 4,Phase 1
10 Peripheral Nervous System Agents Phase 4,Phase 1
11 Central Nervous System Depressants Phase 4
12 Anesthetics Phase 4
13 Anesthetics, Local Phase 4
14 Anti-Arrhythmia Agents Phase 4
15 Diuretics, Potassium Sparing Phase 4
16 Sodium Channel Blockers Phase 4
17
Salicylic acid Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2,Early Phase 1 69-72-7 338
18 Lemon Balm Nutraceutical Phase 3
19 Poke Nutraceutical Phase 3
20
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2,Early Phase 1 22916-47-8 4189
21 Antifungal Agents Phase 1, Phase 2,Early Phase 1
22 Anti-Infective Agents Phase 1, Phase 2,Early Phase 1
23 Dermatologic Agents Phase 1, Phase 2,Early Phase 1
24 Keratolytic Agents Phase 1, Phase 2,Early Phase 1
25
Gabapentin Approved, Investigational 60142-96-3 3446
26
gamma-Aminobutyric acid Approved, Investigational 56-12-2 119
27
Buspirone Approved, Investigational 36505-84-7 2477
28
Clonidine Approved 4205-90-7 2803
29
Hydrocortisone Approved, Vet_approved Early Phase 1 50-23-7 657311 5754
30
Butyric Acid Experimental, Investigational Early Phase 1 107-92-6 264
31 Pharmaceutical Solutions
32 Analgesics
33 Anti-Anxiety Agents
34 Anticonvulsants
35 Antimanic Agents
36 Antiparkinson Agents
37 calcium channel blockers
38 Calcium, Dietary
39 Excitatory Amino Acid Antagonists
40 Excitatory Amino Acids
41 GABA Agents
42 Psychotropic Drugs
43 Tranquilizing Agents
44 Antidepressive Agents
45 Lithium carbonate 554-13-2
46 Adrenergic Agents
47 Adrenergic Agonists
48 Adrenergic alpha-2 Receptor Agonists
49 Adrenergic alpha-Agonists
50 Antihypertensive Agents

Interventional clinical trials:

(show all 39)

# Name Status NCT ID Phase Drugs
1 Study of the Safety and Efficacy of Botox in Bruxism Unknown status NCT00908050 Phase 4 Botulinum toxin type A
2 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
3 Nocturnal Mouth Guards, SOVA vs. Standard Acrylic Orthotic; Phase IV Completed NCT02340663 Phase 4
4 Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques Terminated NCT00992108 Phase 4 lidocaine;chemodenervation
5 Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial Completed NCT01268605 Phase 3
6 The Platelet-Rich Plasma in the Therapy of Temporomandibular Disorders Recruiting NCT03371888 Phase 2, Phase 3
7 Efficacy of Phytolacca Decandra and Melissa Officinalis in Children With Nocturnal Bruxism Active, not recruiting NCT02870543 Phase 3 Phytolacca decandra;Melissa officinalis;Phyt.decandra + Melissa offic.
8 The Influence of Oral Vibrational Stimulation on Cognitive Function of Elderly Individuals Unknown status NCT02332525 Phase 1, Phase 2
9 Physiotherapy on the Airway of Bruxist Children Completed NCT01178229 Phase 1, Phase 2
10 Occlusal Adjustment as Treatment for Chronic Orofacial Pain Completed NCT00899717 Phase 1, Phase 2
11 Botox for Treatment of TMJ Disorder With Bruxism Withdrawn NCT02202070 Phase 1 onabotulinumtoxinA
12 Relationship of Facial Pattern With Bruxism Unknown status NCT00868244
13 TMJ NextGen Pilot Study to Treat Subjects With Bruxism Unknown status NCT02446288
14 Reduction of Masticatory Muscle Activity by Restoring Canine Guidance Unknown status NCT02235220
15 Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea Unknown status NCT00520156
16 Respiratory Problems and Caries in Children With Bruxism Completed NCT01463826
17 Floral Remedies for Sleep-bruxism Patients Completed NCT03112954 Buccal-relaxant formula;Placebo
18 Treatment Sleep Bruxism With the Luco Hybrid OSA Appliance Completed NCT02882880
19 Comparative Evaluation of Gabapentine and Occlusal Splint in the Management of Sleep Bruxism Completed NCT01255878 Gabapentine
20 TMJ NextGeneration(TM) Feasibility Study Completed NCT02257320
21 Effects of the Continuous Wear of Invisalign® Trays on the Temporomandibular Joints and Orofacial Muscular Complex Completed NCT01812850
22 Effects of Dry Needling in Patients With Sleep Bruxism and Temporomandibular Disorders: a Prospective Case Series Completed NCT02587182
23 A Clinical Trial of the Optimal Treatment Period and Long-term Efficacy of Functional Electrical Stimulation (FES) on Sleep Bruxism Completed NCT01000389
24 Oral Appliance in Obstructive Sleep Apnea. A Randomized Controlled Blinded Multicenter Study Comparing Two Devices Completed NCT02148510
25 Conservative Treatment of Patients With Temporomandibular Disorders Completed NCT01021306
26 Prevalence of Bruxism in a Group of Preschool Egyptian Children Recruiting NCT03006133
27 All-ceramic Crowns in Patients With Sleep Bruxism Recruiting NCT03039985
28 Restoring Masticatory Function to Treat Chronic Pain Recruiting NCT02144233
29 Physical Therapy Interventions Relative to Dental Treatment in Individuals With Bruxism Active, not recruiting NCT01778881
30 Sleep Bruxism and (Peri-)Implant Complications Active, not recruiting NCT02410681
31 Evaluation of Selected Disorders With Sleep Bruxism Enrolling by invitation NCT03083405 Clonidine;Buspirone
32 Evaluation of Muscle Activity, Bite Force and Salivary Cortisol in Children With Bruxism Not yet recruiting NCT02757261 Early Phase 1
33 Validation of a Diagnostic Method for Quantification of Sleep Bruxism Not yet recruiting NCT03325920
34 Interest of the BRUXENSE Occlusal Splints for Bruxism Diagnosis: a Feasibility Study Not yet recruiting NCT03363204
35 Evaluation of Biofeedback Therapy Efficiency in Sleep Bruxism and Masticatory Muscles Pain Management Not yet recruiting NCT03421028
36 Clinical Efficacy of Crowns Fabricated Using LuxaCrown Not yet recruiting NCT03160950
37 Treatment Period and Long-term Efficacy of Functional Electrical Stimulation (FES) on Sleep Bruxism Terminated NCT01005511
38 Treatment Period and Long-term Effect of Functional Electric Stimulation (FES) for Bruxism Terminated NCT00807430
39 TMJ-1001 Bruxism Run-In/Pivotal Trial Withdrawn NCT02269553

Search NIH Clinical Center for Bruxism

Cochrane evidence based reviews: bruxism

Genetic Tests for Bruxism

Genetic tests related to Bruxism:

# Genetic test Affiliating Genes
1 Bruxism 28

Anatomical Context for Bruxism

MalaCards organs/tissues related to Bruxism:

38
Brain, Eye, Bone, Heart, Testes, Pineal, Kidney

Publications for Bruxism

Articles related to Bruxism:

(show top 50) (show all 649)
# Title Authors Year
1
Relationship of self-reported sleep bruxism and awake bruxism with chronotype profiles in Italian dental students. ( 29376478 )
2018
2
Long-term variability of sleep bruxism and psychological stress in patients with jaw-muscle pain: Report of two longitudinal clinical cases. ( 29197103 )
2018
3
Insufficient evidence about sleep bruxism being a risk factor for ceramic restoration failure. ( 29150017 )
2018
4
The risk factors related to bruxism in children: A systematic review and meta-analysis. ( 29149621 )
2018
5
Evaluation of the association of bruxism, psychosocial and sociodemographic factors in preschoolers. ( 29412225 )
2018
6
Onabotulinum toxin-A injections for sleep bruxism: A double-blind, placebo-controlled study. ( 29343468 )
2018
7
Polysomnography-Detected Bruxism in Children is Associated With Somatic Complaints But Not Anxiety. ( 29198292 )
2018
8
Association of possible sleep bruxism in children with different chronotype profiles and sleep characteristics. ( 29363987 )
2018
9
Changes in the temporomandibular joint disc and temporal and masseter muscles secondary to bruxism in Turkish patients. ( 29332113 )
2018
10
Can oral appliances reduce sleep bruxism?: Oral appliances for managing sleep bruxism in adults: a systematic review from 2007 to 2017. ( 29372702 )
2018
11
Sleep behaviors in children with different frequencies of parental-reported sleep bruxism. ( 28807776 )
2017
12
The effectiveness of an occlusal disclosure sheet to diagnose sleep bruxism: A pilot study. ( 29179652 )
2017
13
Mother's Work Status on Children's Bruxism in a Subset of Saudi Population. ( 29285473 )
2017
14
Sleep bruxism and related risk factors in adults: A systematic literature review. ( 28692828 )
2017
15
Treatment of chronic pain associated with bruxism through Myofunctional therapy. ( 29118958 )
2017
16
Therapies for bruxism: a systematic review and network meta-analysis (protocol). ( 28086992 )
2017
17
Success Rate and Technical Quality of Home Polysomnography with Self-Applicable Electrode Set in Subjects with Possible Sleep Bruxism. ( 28829322 )
2017
18
The prevalence of sleep bruxism and associated factors in children: a report by parents. ( 29075962 )
2017
19
Relationship between obstructive sleep apnoea syndrome and sleep bruxism: a systematic review. ( 27977045 )
2017
20
Prosthodontic planning in patients with temporomandibular disorders and/or bruxism: a systematic review. ( 28798446 )
2017
21
Oral appliances for managing sleep bruxism in adults: a systematic review from 2007 to 2017. ( 28859236 )
2017
22
The effects of stabilization splint treatment on the volume of masseter muscle in sleep bruxism patients. ( 28920539 )
2017
23
Prevalence of bruxism and temporomandibular disorders among orphans in southeast Uganda: A gender and age comparison. ( 28555521 )
2017
24
Homeopathic therapy for sleep bruxism in a child: Findings of a 2-year case report. ( 28914254 )
2017
25
Personality traits and dental anxiety in self-reported bruxism. A cross-sectional study. ( 28684309 )
2017
26
No convincing evidence of an association between young mothers' psychological traits and sleep bruxism in toddlers. ( 28550852 )
2017
27
Bruxism, Botox, and Dental Implants. ( 29235317 )
2017
28
Clinical Decision Support Model to Predict Occlusal Force in Bruxism Patients. ( 29181234 )
2017
29
The Evaluation of the Clinical Effects of Botulinum Toxin on Nocturnal Bruxism. ( 28757802 )
2017
30
Nocturnal sleep architecture is altered by sleep bruxism. ( 28883558 )
2017
31
Decreased GABA Levels in the Brainstem in Patients with Possible Sleep Bruxism: A Pilot Study. ( 28891592 )
2017
32
Effect of interocclusal appliance on bite force, sleep quality, salivary cortisol levels and signs and symptoms of temporomandibular dysfunction in adults with sleep bruxism. ( 28601734 )
2017
33
Companion of oral movements with limb movements in patients with sleep bruxism: preliminary findings. ( 28735914 )
2017
34
Evaluation of muscle activity, bite force and salivary cortisol in children with bruxism before and after low level laser applied to acupoints: study protocol for a randomised controlled trial. ( 28789647 )
2017
35
Association of malocclusion, self-reported bruxism and chewing-side preference with oral health-related quality of life in patients with temporomandibular joint osteoarthritis. ( 29094335 )
2017
36
Proton pump inhibitor shows no convincing evidence of efficacy for treating sleep bruxism. ( 28550850 )
2017
37
The clinical management of awake bruxism. ( 28550845 )
2017
38
Aesthetic Treatment of Bruxism. ( 28670358 )
2017
39
Sleep and awake bruxism in adults and its relationship with temporomandibular disorders: A systematic review from 2003 to 2014. ( 27796166 )
2017
40
The relationship between bruxism, sleep quality, and headaches in schoolchildren. ( 29200617 )
2017
41
Current Concepts of Bruxism. ( 28806429 )
2017
42
A cure for bruxism. ( 29205719 )
2017
43
Dental erosion: Bitterness-induced bruxism. ( 29269905 )
2017
44
Sleep bruxism in children: sleep studies correlate poorly with parental reports. ( 27198949 )
2016
45
Bruxism in Movement Disorders: A Comprehensive Review. ( 27077925 )
2016
46
Impact of sleep bruxism on masseter and temporalis muscles and bite force. ( 27077268 )
2016
47
Sleep bruxism: Current knowledge and contemporary management. ( 27656052 )
2016
48
Self-Reported bruxism and associated factors in Israeli adolescents. ( 26968152 )
2016
49
Effect of mandibular advancement device on sleep bruxism score and sleep quality. ( 27422230 )
2016
50
A randomised, open-label, crossover study of the dopamine agonist, pramipexole, in patients with sleep bruxism. ( 27426276 )
2016

Variations for Bruxism

Expression for Bruxism

Search GEO for disease gene expression data for Bruxism.

Pathways for Bruxism

Pathways related to Bruxism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.01 HTR2A MECP2 SLC6A4
2 10.4 HTR2A SLC6A4

GO Terms for Bruxism

Biological processes related to Bruxism according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.71 DRD2 HTR2A SLC6A4
2 response to hypoxia GO:0001666 9.61 DRD2 MECP2 SLC6A4
3 sensory perception of pain GO:0019233 9.52 HTR2A MECP2
4 social behavior GO:0035176 9.51 MECP2 SLC6A4
5 visual learning GO:0008542 9.49 DRD2 MECP2
6 release of sequestered calcium ion into cytosol GO:0051209 9.48 DRD2 HTR2A
7 long-term memory GO:0007616 9.46 DRD2 MECP2
8 regulation of dopamine secretion GO:0014059 9.4 DRD2 HTR2A
9 behavioral response to cocaine GO:0048148 9.37 DRD2 HTR2A
10 temperature homeostasis GO:0001659 9.32 DRD2 HTR2A
11 startle response GO:0001964 9.26 DRD2 MECP2
12 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.16 DRD2 HTR2A
13 memory GO:0007613 9.13 HTR2A MECP2 SLC6A4
14 neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 8.62 DRD2 MECP2

Sources for Bruxism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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